Breast Balance®
Patented Bioavailable Diindolylmethane
with Vitamin D, Iodine, and Selenium
Now with 150mg of BioResponse DIM® per capsule!
INGREDIENTS
BioResponse DIM®
"DIM" stands for Diindolylmethane, a natural dietary indole
found in cruciferous vegetables. DIM occurs within the cruciferous vegetable plant after crushing or chewing. Plant enzymes
produce DIM from precursors called glucosinolates. When added
to the diet, absorbable DIM helps balance estrogen metabolism.
Achieve breast comfort. Recent studies show that chronic,
recurrent breast pain is associated with future breast cancer risk1.
BioResponse DIM supplements were studied in a randomized,
placebo-controlled trial and were shown to promote breast
comfort and healthy estrogen metabolism2.
DIM promotes beneficial estrogen metabolism in both
women and men. Studies have shown that estrogen-related
disorder risk in women relates to unfavorable estrogen
metabolism3,4. Healthy estrogen metabolism has been shown in
prospective studies to be predictive of a lower risk of estrogenrelated disorders4. Absorbable DIM has been shown to promote
greater metabolism of estrogen to 2-hydroxy estrogens5.
2-hydroxy forms of estrogen are considered beneficial6. DIM
promotes estrogen metabolism, but is not a plant estrogen.
Patented BioResponse DIM® is the original and only DIM with
proven absorption and benefits demonstrated in independently
performed clinical studies. This patented technology is currently
the only nutrient delivery method that assures predictable
absorption and sustained delivery of DIM.
SUPPLEMENT FACTS
Serving size: 1 Capsule
Servings per Container: 60
Amount per Serving
%DV*
600 IU 150%
Vitamin D3
150 mcg 100%
Iodine (from kelp)
Selenium (Selenium Trituration [selenite]) 100 mcg 143%
BioResponse DIM® (BR-DIM®) 150 mg
*
B-DIM™ (A patented, enhanced bioavailability complex
containing min. 25% diindolylmethane), starch, diindolylmethane,
Vitamin E (as d-alpha tocopheryl succinate [tocophersolan]), soy
phosphatidyl choline, silica.
*Daily value (DV) not established.
Other ingredients: Rice, vegetable cellulose (capsule), potassium amino
acid chelate, calcium carbonate, magnesium stearate, silicon dioxide,
titanium dioxide (capsule). No added yeast, salt, sugar, wheat, gluten,
milk, artificial coloring, preservatives or ingredients from animal sources.
All published clinical studies have ONLY used the patented
formulation of DIM, BioResponse DIM®.
BioResponse DIM® is also currently the only DIM in clinical
trials sponsored by the National Cancer Institute.
Uses of DIM for breast health, developed by BioResponse, are
covered by US Patent # 6,689,387.
Vitamin D3
Recent studies support both the safety and potential benefits of
increased daily Vitamin D intake7. Breast Balance provides 600
I.U.’s of Vitamin D per capsule which provides for supplementation within current suggested intakes of Vitamin D up to 2,000
I.U.’s per day. Studies also support an association between
increased Vitamin D intake and breast health8.
Iodine
Breast Balance provides Iodine in the form of elemental iodine
which is different from Potassium Iodide available from iodized
salt. Breast tissue is known to concentrate iodine, but this process
requires elemental iodine9. Breast Balance provides 100% of the
recommended daily value of Iodine. Increased iodine intake
has been associated with breast health10.
Selenium
Breast Balance provides selenium in the form of inorganic
selenium from sodium selenite. This form of selenium has been
shown to be most active for incorporation of selenium into the
active sites of essential selenoenzymes. Adequate selenium
intake is necessary for both thyroid hormone action and
breast health11. Deficient selenium has been associated with
fibrocystic changes in breast tissue12.
RECOMMENDATIONS
Take 1-2 capsules daily or as directed by your physician or health
care provider.
PRECAUTIONS
Individuals with allergies to corn or soy should not take the
product as some of the ingredients in the patented formulation
are derived from these sources. Do not use if you are pregnant,
may become pregnant, or lactating. Harmless changes in urine
color may occur with the use of this product.
*These statements have not been evaluated by the FDA. This product is
not intended to diagnose, treat, cure or prevent any disease.
REFERENCES
1. Plu-Bureau G, Le MG, Sitruk-Ware R, Thalabard JC. Cyclical mastalgia and breast cancer risk: results of a French
cohort study. Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1229-31.
2. Zeligs, MA., Brownstone PK, Sharp, ME, Westerlind KC, Wilson, SM, and Johs SM. Managing Cyclical Mastalgia with
Absorbable Diindolymethane: A Randomized, Placebo-controlled Trial. JANA. 2005. 8(1): 5-15.
3. Okobia MN, Bunker CH. Estrogen metabolism and breast cancer risk—a review. Afr J Reprod Health. 2006
Apr;10(1):13-25.
4. Muti P, Bradlow HL, Micheli A, Krogh V, Freudenheim JL, Schunemann HJ, Stanulla M, Yang J, Sepkovic DW, Trevisan
M, Berrino F. Estrogen metabolism and risk of breast cancer: a prospective study of the 2:16alpha-hydroxyestrone
ratio in premenopausal and postmenopausal women. Epidemiology. 2000 Nov;11(6):635-40.
5. Dalessandri KM, Firestone GL, Fitch MD, Bradlow HL, Bjeldanes LF. Pilot study: effect of 3,3'-diindolylmethane
supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer.
Nutr Cancer. 2004;50(2):161-7.
6. Bradlow HL, Telang NT, Sepkovic DW, Osborne MP. 2-hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996
Sep;150 Suppl:S259-65.
7. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a
new effective dietary intake recommendation for vitamin D. J Nutr. 2005 Feb;135(2):317-22.
8. Garland CF, Gorham ED, Mohr SB, Grant WB, Giovannucci EL, Lipkin M, Newmark H, Holick MF, Garland FC. Vitamin D
and prevention of breast cancer: pooled analysis.J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):708-11.
9. MacFarlane JK. Elemental iodine: relief for the painful breast? Can J Surg. 1993 Oct;36(5):405.
10. Ghent WR, Eskin BA, Low DA, Hill LP. Iodine replacement in fibrocystic disease of the breast. Can J Surg. 1993
Oct;36(5):453-60.
11. Gartner R, Gasnier BC, Dietrich JW, Krebs B, Angstwurm MW. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab. 2002
Apr;87(4):1687-91.
12. Smyth PP. Role of iodine in antioxidant defence in thyroid and breast disease. Biofactors. 2003;19(3-4):121-30.
Review.
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