Connector type Delivered Energy (approx.) DF-1 30 J Name Model Number Current Accel VR CD1215-30 Single-chamber ICD with RF telemetry Fortify™ DR CD2233-40 Dual-chamber ICD DF-1/IS-1 with RF telemetry 40 J Fortify DR CD2233-40Q Dual-chamber ICD DF4-LLHH/IS-1 with RF telemetry 40 J Fortify ST DR CD2235-40 Dual-chamber ICD DF-1/IS-1 with RF telemetry 40 J Fortify ST DR CD2235-40Q Dual-chamber ICD DF4-LLHH/IS-1 with RF telemetry 40 J Fortify ST VR CD1235-40 Single-chamber ICD with RF telemetry DF-1/IS-1 40 J Fortify ST VR CD1235-40Q Single-chamber ICD with RF telemetry DF4-LLHH 40 J Fortify VR CD1233-40 Single-chamber ICD with RF telemetry DF-1/IS-1 40 J Fortify VR CD1233-40Q Single-chamber ICD with RF telemetry DF4-LLHH 40 J Promote + CD3211-36 CRT-D with RF telemetry DF-1/IS-1 36 J Promote + CD3211-36Q CRT-D with RF telemetry DF4-LLHH/IS-1 36 J Promote 3107-36 CRT-D DF-1/IS-1 36 J Promote 3107-36Q CRT-D DF4-LLHH/IS-1 36 J Promote 3107-30 CRT-D DF-1/IS-1 30 J Promote 3109-36 CRT-D with LVonly pacing DF-1/IS-1 36 J Promote 3109-30 CRT-D with LVonly pacing DF-1/IS-1 30 J Promote CD3207-36Q CRT-D with RF telemetry DF4-LLHH/IS-1 36 J Promote RF 3207-36 CRT-D with RF telemetry DF-1/IS-1 36 J Description Table 1. Pulse generator descriptions (continued) St. Jude Medical™ High-Voltage Devices User’s Manual XXXX XXXX XXXX Reference Manual 3 1-3 Connector type Delivered Energy (approx.) Name Model Number Promote RF 3207-30 CRT-D with RF telemetry DF-1/IS-1 30 J Promote RF 3213-36 CRT-D with LVonly pacing and RF telemetry DF-1/IS-1 36 J Promote RF 3213-30 CRT-D with LVonly pacing and RF telemetry DF-1/IS-1 30 J Promote Accel CD3215-36 CRT-D with RF telemetry DF-1/IS-1 36 J Promote Accel CD3215-36Q CRT-D with RF telemetry DF4-LLHH/IS-1 36 J Promote Accel CD3215-30 CRT-D with LVonly pacing and RF telemetry DF-1/IS-1 30 J Promote Q CD3221-36 CRT-D DF-1/SJ4-LLLL/ IS-1 36 J Promote Q CD3227-36 CRT-D DF-1/SJ4-LLLL/ IS-1 36 J Promote Quadra CD3237-40 CRT-D with RF telemetry DF-1/DF4-LLHH 40 J Promote Quadra CD3237-40Q CRT-D with RF telemetry DF4-LLHH/ SJ4-LLLL/IS-1 Promote Quadra CD3239-40 CRT-D with RF telemetry DF-1/DF4-LLHH 40 J Promote Quadra CD3239-40Q CRT-D with RF telemetry DF4-LLHH/ SJ4-LLLL/IS-1 40 J Unify™ CD3235-40 CRT-D with RF telemetry DF-1/IS-1 40 J Unify CD3235-40Q CRT-D with RF telemetry DF4-LLHH/IS-1 40 J Description 40 J Table 1. Pulse generator descriptions (continued) 1. SJ4-LLHH is compatible with DF4-LLHH. SJ4 and DF4 connectors comply with ISO27186:2010(E). These devices can be programmed with the Merlin™ Patient Care System equipped with Model 3330 version 10.2 (or greater) software. For information on programming, refer to the programmer’s on-screen help. 4 Device Description 1-4 Device Description Indications The devices are intended to provide ventricular antitachycardia pacing and ventricular defibrillation for automated treatment of life-threatening ventricular arrhythmias. Cardiac Resynchronization Therapy devices (CRT-Ds) are also intended to resynchronize the right and left ventricles in patients with congestive heart failure. Contraindications Contraindications for use of the pulse generator system include ventricular tachyarrhythmias resulting from transient or correctable factors such as drug toxicity, electrolyte imbalance, or acute myocardial infarction. Warnings Implantation Procedure • The physician should be familiar with all components of the system and the material in this manual before beginning the procedure. • Ensure that a separate standby external defibrillator is immediately available. • Implant the pulse generator no deeper than 5 cm to ensure reliable data transmission. For patient comfort, do not implant the pulse generator within 1.25 cm of bone unless you cannot avoid it. Device Replacement • Replace the pulse generator within three months of reaching ERI. Replace the pulse generator immediately upon reaching ERI if there is frequent high-voltage charging and/or one or more of the pacing outputs are programmed above 2.5 V. See Table 16 on page 34. Battery Incineration • Do not incinerate pulse generators as they contain sealed chemical power cells and capacitors that may explode. Return explanted devices to St. Jude Medical. High-Voltage Can • Ensure that tachyarrhythmia therapy is programmed Off before handling the pulse generator to avoid any risk of accidental shock. Do not program tachyarrhythmia therapies On until the pulse generator is inserted in the pocket. St. Jude Medical™ High-Voltage Devices User’s Manual XXXX XXXX XXXX Reference Manual 5 1-5 • For effective defibrillation, perform all defibrillation testing with the can in the pocket. Magnetic Resonance Imaging (MRI) • Avoid MRI devices because of the magnitude of the magnetic fields and the strength of the radiofrequency (RF) fields they produce. Precautions Device Modification • This device has been tested for compliance to FCC regulations. Changes or modifications of any kind not expressly approved by St. Jude Medical Inc. could void the user’s authority to operate this device. Device Storage • Store the pulse generator at temperatures between 10° and 45°C. Do not subject it to temperatures below -20° or over 60°C. • After cold storage, allow the device to reach room temperature before charging the capacitors, programming, or implanting the device because cold temperature may affect initial device function. Lead Impedance • Do not implant the pulse generator if the acute defibrillation lead impedance is less than 20 ¬ or the lead impedance of chronic leads is less than 15 ¬. Damage to the device may result if high-voltage therapy is delivered into an impedance less than 15 ¬. Device Communication • Communication with the device can be affected by electrical interference and strong magnetic fields. If this is a problem, turn off nearby electrical equipment or move it away from the patient and the programmer. If the problem persists, contact St. Jude Medical. Suboptimal RF Communication • The Merlin™ PCS indicates the quality of the RF communication by the telemetry strength indicator LEDs on both the programmer and the Merlin Antenna. Below is a list of potential causes to suboptimal radio communication: 6 Device Description 1-6 Device Description Possible Causes Solutions The Merlin Antenna orientation/location is suboptimal. Move or reorient the Merlin Antenna slightly. Make sure that the front of the Merlin Antenna faces the implantable device. People or objects interfere with the communication between the Merlin Antenna and the device. Make sure that the space between the Merlin Antenna and the device is free from interfering objects/people. The Merlin Antenna is too far away from the Move the Merlin Antenna closer to the device. device. Someone is holding the Merlin Antenna. Place the Merlin Antenna on a flat surface. Do not hold the Merlin Antenna. Other products in the vicinity are causing electromagnetic interference (EMI). Power off or remove equipment that could cause EMI. The Merlin Antenna cable is wound around the Merlin Antenna. Make sure the Merlin Antenna cable is not wound around the Merlin Antenna. Table 2. Possible causes and solutions for suboptimal RF communication Disconnecting Leads • Connecting or disconnecting sense/pace leads can produce electrical artifacts that can be sensed by the pulse generator. To prevent detection of artifacts, reprogram the pulse generator to tachyarrhythmia therapy Off: - Before disconnecting the leads from a pulse generator in the operating room - Before a post-mortem examination - Whenever there are no leads connected to it - When sense/pace leads are connected but are not implanted in a patient If a programmer is not available, use a magnet to prevent delivery of tachyarrhythmia therapy in response to detected disconnection artifacts. Place the magnet over the pulse generator before disconnecting the leads. Do not remove it until the leads are reconnected. CAUTION The Magnet Response parameter must be set to Normal for the magnet to prevent the delivery of tachyarrhythmia therapy. For more information, see ”Using a Magnet” on page 25. St. Jude Medical™ High-Voltage Devices User’s Manual XXXX XXXX XXXX Reference Manual 7 1-7 External Equipment for Arrhythmia Induction • If external equipment is used for arrhythmia induction through the pulse generator header and leads, apply rectified AC current through the highvoltage ports, not the sense/pace ports, to avoid damaging the sense/pace function. • Disconnect the external equipment from the pulse generator before any therapy is delivered; otherwise, damage to the device is likely to occur. Place a magnet over the device until the external equipment can be disconnected. Antiarrhythmic Drugs • Antiarrhythmic drugs may alter the defibrillation energy threshold, rendering the pulse generator’s countershock ineffective or causing the shock to induce a clinically significant arrhythmia. In addition, changing cardiac electrical characteristics may prevent detection of a tachyarrhythmia or may cause the pulse generator to misinterpret a normal rhythm as a clinically significant arrhythmia. Changes in medication may require defibrillation threshold testing, updating the morphology template, and reprogramming of the device. Sterilization • The package contents have been sterilized with ethylene oxide before shipment. This device is for single use only and is not intended to be resterilized. • If the sterile package has been compromised, contact St. Jude Medical. Environmental Hazards • External devices generating strong electromagnetic fields can cause operational problems in the pulse generator that include, but are not limited to: cessation of or intermittent bradycardia pacing, and inadvertent antitachycardia pacing, cardioversion, or defibrillation. Additionally, high-energy induced or conducted currents can reset the programmed parameters and damage the pulse generator and tissue surrounding the implanted lead electrodes. Additional Pacemaker • These devices provide bradycardia pacing. If another pacemaker is used, it should have a bipolar pacing reset mode and be programmed for bipolar pacing to minimize the possibility of the output pulses being detected by the device. 8 Device Description 1-8 Device Description External Defibrillators • Shocks of sufficient strength can reset the programmed parameters or damage the pulse generator and/or the tissue around the lead electrodes. Whenever possible, disconnect the pulse generator from its leads before applying defibrillator paddles. • The effectiveness of external defibrillation may be reduced due to the insulating effect of the implanted defibrillation electrodes. Minimize this with proper external paddle placement relative to the orientation of the implanted defibrillation electrodes. Deliver the energy perpendicular to a line between the two implanted electrodes. • As soon as possible after external/internal defibrillation, check the pulse generator by verifying that: - Programmed parameters remain as previously programmed - Measurements (battery voltage, lead impedances, etc.) are appropriate - Real-time EGM and status information indicate appropriate sensing of cardiac signals - Capture is maintained during bradycardia pacing • Verify the proper functioning of the output circuitry by delivering a synchronous emergency shock. • External defibrillation may reprogram the device to its reset values. Assess any device parameter reset in conjunction with St. Jude Medical Technical Service personnel. Electrosurgical Instruments • The pulse generator may detect electrocautery energy as cardiac events and deliver tachyarrhythmia therapy. Electrocautery can also cause tissue damage near the implanted electrodes, damage the pulse generator, or reprogram the device to its reset values. Position the electrocautery ground electrode to minimize current flow through the implanted electrode system. Do not apply electrocautery directly to the pulse generator. • During electrosurgery, disable tachyarrhythmia therapy (Enable/Disable Tachy Therapy) or program tachyarrhythmia therapy Off. If a programmer is unavailable, use a magnet to inhibit delivery of tachyarrhythmia therapy. Therapeutic Radiation • Use devices emitting ionizing radiation with caution as they can damage CMOS circuitry in the pulse generator. Devices such as linear accelerators, betatrons and cobalt machines can be used with proper therapeutic planning to minimize cumulative dosage levels to the pulse generator. Diagnostic X-rays, although a source of ionizing radiation, generally produce much lower levels and are not contraindicated. Consultation with clinical physicists and St. Jude Medical is recommended. St. Jude Medical™ High-Voltage Devices User’s Manual XXXX XXXX XXXX Reference Manual 9 1-9 Medical Lithotripsy • Avoid lithotripsy unless the therapy site is not near the pulse generator and leads as lithotripsy may damage the pulse generator. Diathermy • Avoid diathermy, even if the device is programmed off, as it may damage tissue around the implanted electrodes or may permanently damage the pulse generator. Ultrasound Therapy • Diagnostic and therapeutic ultrasound treatment is not known to affect the function of the pulse generator. Home and Industrial Environments • A variety of devices produce electromagnetic interference (EMI) of sufficient field strength and modulation characteristics to interfere with proper operation of the pulse generator. These include, but are not limited to: high-powered radio, television, and radar transmitters/antennas; arc welders; induction furnaces; very large or defective electric motors; and internal combustion engines with poorly shielded ignition systems. • The patient should avoid strong magnetic fields since they are potentially capable of inhibiting tachyarrhythmia therapies. If a patient is frequently in a high-magnetic-field environment and therefore at risk of not having therapies delivered, you may choose to program the device to ignore magnetic fields. Therapies would then be delivered in the normal manner in response to detected arrhythmias. Magnet application would have no effect on operation. Electronic Article Surveillance (EAS) Advise patients that the Electronic Article Surveillance/Anti-theft systems or Electronic Article Surveillance (EAS) systems such as those at the point of sale and entrances/exits of stores, libraries, banks, etc., emit signals that may interact with ICDs and CRT-Ds. It is very unlikely that these systems will interact with their device significantly. However, to minimize the possibility of interaction, advise patients to simply walk through these areas at a normal pace and avoid lingering near or leaning on these systems. Metal Detectors Advise patients that metal detector security systems such as those found in airports and government buildings emit signals that may interact with ICDs and CRT-Ds. It is very unlikely that these systems will interact with their device significantly. To minimize the possibility of interaction, advise patients to simply 10 Device Description 1-10 Device Description walk through these areas at a normal pace and avoid lingering. Even so, the ICD and CRT-D systems contain metal that may set off the airport security system alarm. If the alarm does sound, the patient should present security personnel with their patient identification card. If security personnel perform a search with a handheld wand, they should ask the security personnel to perform the search quickly, stressing that they should avoid holding the wand over the device for a prolonged period. Cellular Phones The pulse generator has been tested for compatibility with handheld wireless transmitters in accordance with the requirements of AAMI PC69. This testing covered the operating frequencies (450 MHz - 3 GHz) and pulsed modulation techniques of all of the digital cellular phone technologies in worldwide use today. Based on the results of this testing, the pulse generator should not be affected by the normal operation of cellular phones. Adverse Events Implantation of the pulse generator system, like that of any other device, involves risks, some possibly life-threatening. These include but are not limited to the following: • Acute hemorrhage/bleeding • Air emboli • Arrhythmia acceleration • Cardiac or venous perforation • Cardiogenic shock • Cyst formation • Erosion • Exacerbation of heart failure • Extrusion • Fibrotic tissue growth • Fluid accumulation • Hematoma formation • Histotoxic reactions • Infection • Keloid formation • Myocardial irritability • Nerve damage • Pneumothorax • Thromboemboli • Venous occlusion St. Jude Medical™ High-Voltage Devices User’s Manual XXXX XXXX XXXX Reference Manual 11 1-11 Other possible adverse effects include mortality due to: • Component failure • Device-programmer communication failure • Lead abrasion • Lead dislodgment or poor lead placement • Lead fracture • Inability to defibrillate • Inhibited therapy for a ventricular tachycardia • Interruption of function due to electrical or magnetic interference • Shunting of energy from defibrillation paddles • System failure due to ionizing radiation Other possible adverse effects include mortality due to inappropriate delivery of therapy caused by: • Multiple counting of cardiac events including T-waves, P-waves, or supplemental pacemaker stimuli Among the psychological effects of device implantation are imagined pulsing, dependency, fear of inappropriate pulsing, and fear of losing pulse capability. Persons administering cardiopulmonary resuscitation (CPR) have reportedly been startled by voltage present on the patient’s body surface during discharge of the pulse generator. The voltage decreases as the discharge disperses toward the periphery of the body, and is weakest at the furthest extension of the limbs. Nevertheless, there is a highly remote possibility that an arrhythmia may be induced in someone administering CPR to the patient at the time a countershock is delivered. 12 Device Description 1-12 Device Description Promote Accel™ CRT-D Cardiac Resynchronisation Therapy Defibrillators (CRT-Ds) with InvisiLink™ Wireless Telemetry MODELS CD3215-30 and CD3215-36 Specifications LV, RV, and Atrial Capture Confirmation features ensure capture of the myocardium in response to pacing stimuli in the left ventricle, right ventricle and right atrium. LVCap™, RVCap™ and ACap™ Confirm help ensure patient safety and therapy delivery by automatically monitoring and adjusting capture thresholds according to changing patient needs. Designed to reduce unnecessary right ventricular pacing, the VIP™ algorithm allows intrinsic conduction when possible and provides optimised ventricular support when needed. Advanced Biventricular Pacing options. – Triggered Pacing with BiV Trigger Mode helps maintain a high percentage of BiV pacing by triggering pacing in both the left and right ventricles in response to a sensed ventricular event. – VectSelect™ programmable LV pulse configuration (LV ring-RV coil, LV tip-RV coil or LV bipolar) may be adjusted noninvasively via the programmer. – Negative AV hysteresis with search promotes ventricular pacing by automatically reducing the AV delay when intrinsic activity is present, thereby promoting a high degree of ventricular pacing. ™ DeFT Response technology tools provide more clinically proven, non-invasive options for managing high DFTs. – Programmable pulse widths allow the user to tailor the shock to the individual patient, making shocks more efficacious.1 – SVC shocking electrode can be quickly and non-invasively activated or deactivated with the press of a button. – 36 J delivered energy (model CD3215-36) provides unsurpassed energy for defibrillation. – Four programmable tilt options are available to accommodate variances among patients.2 – Together, these features may help to prevent additional surgeries. Exclusive SenseAbility™ feature, with Decay Delay and Threshold Start, provides the flexibility to fine-tune sensing to individual patient needs and help eliminate oversensing of T waves, fractionated QRS complexes, and other extraneous signals. ™ QuickOpt Timing Cycle Optimisation provides quick and effective optimisation for more patients at the push of a button.3 – IEGM-based AV and V-V optimisation allows optimised timing without need for echo-guided optimisation. – V-V timing optimisation may help improve patient outcomes. Because not all patients respond to simultaneous biventricular pacing, programmable timing of right- and left-ventricular outputs helps to ensure appropriate therapy and may reduce the number of non-responders.4 Exclusive Morphology Discrimination plus AV Rate Branch SVT discrimination feature helps reduce the risk of inappropriate ICD shocks and is intended to promote fast, accurate diagnosis and delivery of therapy. Clinical data states that this combination resulted in a sensitivity of 100% with a specificity of 85%.5 Exclusive AF Suppression™ algorithm is clinically proven to suppress episodes of paroxysmal and persistent AF. – Studies show a 25% decrease in symptomatic AF burden.6 AT/AF Alerts notify patients and their clinics when a programmed AT/AF threshold or continuous episode duration has been exceeded, or when a high ventricular rate accompanies the AT/AF episode. ™ Exclusive DC Fibber induction has a documented 95,5% success rate for inducing fibrillation on the first induction as compared with a 72,7% success rate for Shock-on-T.7 Exercise Trend Diagnostic provides insight into the patient’s disease state progression and exercise activity. Up to 45 minutes of continuous, fully annotated stored electrograms, including up to 60 seconds of pre-trigger information per electrogram. – Preferential EGM storage capability allows prioritisation of episode storage. Exclusive Vibratory Patient Notifier allows even patients with hearing problems to be alerted to a low battery, lead-related complications and more. Automatic Daily High-Voltage (HV) Lead Integrity Test is designed to automatically test the HV lead on a daily basis to ensure therapy delivery for optimal patient safety. Multiple hardware and software system safeguards for added security and patient comfort. The capability to program multiple ATP schemes per zone has the potential to increase the success of ATP prior to requiring a shock. InvisiLink™ wireless telemetry, in conjunction with the Merlin@home™ transmitter and Merlin.net™ PCN, allows for seamless remote monitoring and follow-up. InvisiLink RF telemetry uses a dedicated range of frequencies designated for medical devices called the MICS (Medical Implant Communications Service) frequency band, which helps reduce the interference seen on frequencies used by common household electronics. Indications: The devices are intended to provide ventricular antitachycardia pacing and ventricular defibrillation for automated treatment of life-threatening ventricular arrhythmias. Cardiac Resynchronisation Therapy devices (CRT-Ds) are also intended to resynchronise the right and left ventricles in patients with congestive heart failure. Contraindications: Contraindications for use of the pulse generator system include ventricular tachyarrhythmias resulting from transient or correctable factors such as drug toxicity, electrolyte imbalance, or acute myocardial infarction. Warnings and Precautions: Implantation Procedure. The physician should be familiar with all components of the system and the material in this manual before beginning the procedure. Ensure that a separate standby external defibrillator is immediately available. Implant the pulse generator no deeper than 5 cm to ensure reliable data transmission. For patient comfort, do not implant the pulse generator within 1,25 cm of bone unless you cannot avoid it. Device Replacement. Replace the pulse generator within three months of reaching the 2,45 V indication. Replace the pulse generator immediately upon reaching 2,45 V if there is frequent high-voltage charging and/or one or more of the pacing outputs are programmed above 2,5 V. Battery Incineration. Do not incinerate pulse generators as they contain sealed chemical power cells and capacitors that may explode. Return explanted devices to St. Jude Medical. High-Voltage Can. Ensure that tachyarrhythmia therapy is programmed Off before handling the pulse generator to avoid any risk of accidental shock. Do not program tachyarrhythmia therapies On until the pulse generator is inserted in the pocket. For effective defibrillation, perform all defibrillation testing with the can in the pocket. Magnetic Resonance Imaging (MRI). Avoid MRI devices because of the magnitude of the magnetic fields and the strength of the radiofrequency (RF) fields they produce. Device Storage. Store the pulse generator at temperatures between 10° and 45°C. Do not subject it to temperatures below -20° or over 60°C. After cold storage, allow the device to reach room temperature before charging the capacitors, programming, or implanting the device because cold temperature may affect initial device function. Device Communication. Communication with the device can be affected by electrical interference and strong magnetic fields. If this is a problem, turn off nearby electrical equipment or move it away from the patient and the programmer. If the problem persists, contact St. Jude Medical. Lead Impedance. Do not implant the pulse generator if the acute defibrillation lead impedance is less than 20 ohms or the lead impedance of chronic leads is less than15 ohms. Damage to the device may result if high-voltage therapy is delivered into an impedance less than 15 ohms. Suboptimal RF Communication. The Merlin™ PCS indicates the quality of the RF communication by the telemetry strength indicator LEDs on both the programmer and the Merlin Antenna. Disconnecting Leads. Connecting or disconnecting sense/pace leads can produce electrical artifacts that can be sensed by the pulse generator. To prevent detection of artifacts, reprogram the pulse generator to tachyarrhythmia therapy Off: Before disconnecting the leads from a pulse generator in the operating room; Before a post-mortem examination; Whenever there are no leads connected to it; When sense/pace leads are connected but are not implanted in a patient. If a programmer is not available, use a magnet to prevent delivery of tachyarrhythmia therapy in response to detected disconnection artifacts. Place the magnet over the pulse generator before disconnecting the leads. Do not remove it until the leads are reconnected. External Equipment for Arrhythmia Induction. If external equipment is used for arrhythmia induction through the pulse generator header and leads, apply rectified AC current through the high-voltage ports, not the sense/pace ports, to avoid damaging the sense/ pace function: disconnect the external equipment from the pulse generator before any therapy is delivered; otherwise, damage to the device is likely to occur. Place a magnet over the device until the external equipment can be disconnected. Adverse Events: Implantation of the pulse generator system, like that of any other device, involves risks, some possibly life-threatening. These include but are not limited to the following: acute hemorrhage/bleeding, air emboli, arrhythmia acceleration, cardiac or venous perforation, cardiogenic shock, cyst formation, erosion, exacerbation of heart failure, extrusion, fibrotic tissue growth, fluid accumulation, hematoma formation, histotoxic reactions, infection, keloid formation, myocardial irritability, nerve damage, pneumothorax, thromboemboli, venous occlusion. Other possible adverse effects include mortality due to: component failure, device-programmer communication failure, lead abrasion, lead dislodgment or poor lead placement, lead fracture, inability to defibrillate, inhibited therapy for a ventricular tachycardia, interruption of function due to electrical or magnetic interference, shunting of energy from defibrillation paddles, system failure due to ionising radiation. Other possible adverse effects include mortality due to inappropriate delivery of therapy caused by: multiple counting of cardiac events including T-waves, P-waves, or supplemental pacemaker stimuli. Among the psychological effects of device implantation are imagined pulsing, dependency, fear of inappropriate pulsing, and fear of losing pulse capability. Refer to the User’s Manual for detailed indications, contraindications, warnings, precautions and potential adverse events. Post-Therapy Pacing (Independently programmable from Bradycardia and ATP ) PHYSICAL SPECIFICATIONS Models Telemetry Delivered Energy Volume (cc) Weight (g) Size (mm) Defibrillation Lead Connections Sense/Pace Lead Connections High Voltage Can CD3215-30 RF 30 J 39 76 80 x 50 x 13 DF-1 IS-1 Electrically active titanium can CD3215-36 RF 36 J 43 82 81 x 50 x 14 DF-1 IS-1 Electrically active titanium can Off, AAI, VVI, DDI, or DDD 30-100 in increments of 5 Off, 0,5; 1; 2,5; 5; 7,5; or 10 Device Testing/Induction Methods DC Fibber™ Pulse Duration (sec) Burst Fibber Cycle Length (ms) Noninvasive Programmed Stimulation (NIPS) 0,5-5,0 20-100 2-25 stimuli with up to three extrastimuli Patient Notifiers PARAMETER SETTINGS V. Triggering (BiV Trigger Mode) QuickOpt™ Timing Cycle Optimisation V-V Timing Interventricular Pace Delay (ms) Ventricular Sensing Ventricular Pacing Chamber Negative AV Hysteresis/Search (ms) Shortest AV Delay (ms) VectSelect™ LV Pulse Configuration Programmable Notifiers (On, Off) Device Reset Entry into Backup VVI Mode Vibration Duration (sec) Number of Vibrations per Notification Number of Notifications Time Between Notifications (hours) On, Off Sensed/paced AV delay, Interventricular Pace delay Simultaneous*, RV First, LV First RV First 10-80 / LV First 15-80 in increments of 5 RV only (not programmable) RV only, biventricular Off, -10 to -120 25-120 LV tip to RV coil, LV bipolar, LV ring to RV coil AF Management Device at ERI, Charge Time Limit Reached, Possible HV Circuit Damage, Atrial Lead Impedance Out of Range, Ventricular Lead Impedance Out of Range, AT/AF Burden On On 2, 4, 6, 8, 10, 12, 14, 16 2 1-16 10, 22 Electrograms and Diagnostics AF Suppression™ Pacing No. of Overdrive Pacing Cycles Maximum AF Suppression Rate On, Off 15-40 in steps of 5 80-150 min-1 Sensing/Detection SenseAbility™ Technology Threshold Start Decay Delay Ventricular Sense Refractory (ms) Detection Zones SVT Discriminators Reconfirmation Automatic Sensitivity Control adjustment for atrial and ventricular events (Post-Sensed, Atrial) 50; 62,5; 75; 100%; (Post-Paced, Atrial) 0,2-3,0 mV; (Post-Sensed, Ventricular) 50; 62,5; 75; 100%; (Post-Paced, Ventricular) Auto, 0,2-3,0 mV (Post-Sense/Post-Pace, Atrial/Ventricular) 0-220 125, 157 VT-1, VT-2, VF AV Rate Branch, Sudden Onset, Interval Stability, Morphology Discrimination (MD) with Manual or Automatic Template Update Continuous sensing during charging Antitachycardia Pacing Therapy ATP Configurations Burst Cycle Length Min. Burst Cycle Length (ms) Number of Bursts/Stimuli Add Stimuli per Burst Ramp, Burst, Scan; 1 or 2 schemes per zone Adaptive, Readaptive or Fixed 150-400 in increments of 5 1-15 with 2-20 Stimuli On, Off High Voltage Output Mode Waveform RV Polarity Electrode Configuration Up to 45 minutes including up to one minute programmable pre-trigger data per VT/VF diagnosis/detection electrograms; triggers include diagnosis, therapy, atrial episode, PMT termination, PC shock delivery, noise reversion, magnet reversion, and morphology template verification Diagram of therapies delivered Directory listing of up to 60 episodes with access to more details including stored electrograms History of bradycardia events and device-initiated charging Trend data and counts Multi-Vector Trend Data Event Histogram, AV Interval Histogram, Mode Switch Duration Histogram, Peak Filtered Rate Histogram, Atrial Heart Rate Histogram, Ventricular Heart Rate Histogram, AT/AF Burden, Exercise and Activity Trending, V Rates During AMS Information regarding PMT detections Pacing lead impedances, high voltage lead impedances, unloaded battery voltage, and signal amplitudes 1 Mouchawar G, Kroll M, Val-Mejias JE et al. ICD waveform optimization: a randomized prospective, pair-sampled multicenter study. PACE 2000; 23 (Part II):1992-1995. 2 Sweeney MO, Natale A, Volosin KJ et al. Prospective randomized comparison of 50%/50% versus 65%/65% tilt biphasic waveform on defibrillation in humans. PACE 2001; 24:60-65. Fixed Pulse Width, Fixed Tilt Biphasic, Monophasic Cathode (-), Anode (+) RV to Can, RV to SVC/Can 3 Baker et al. Acute evaluation of programmer-guided AV/PV and VV delay optimization comparing an IEGM method and echocardiogram for cardiac resynchronization therapy in heart failure patients and dual-chamber ICD implants. Journal of Cardiovascular Electrophysiology, Vol. 18 No. 2, Feb. 2007. 4 Chan et al. Tissue Doppler guided optimization of A-V and V-V delay of biventricular pacemaker improves response to cardiac resynchronization therapy in heart failure patients. J Cardiac Failure 2004; 10:4 (supplement): 572 (abstract 199). Bradycardia Pacing Permanent Modes Off, DDD(R), DDT(R), DDI(R), VVT(R), VVI(R), AAI(R) Temporary Modes Off, DDD(R), DDT(R), DDI(R), VVT(R), VVI(R), AAI(R), AAT, DOO, VOO, AOO Rate-Adaptive Sensor On, Off, Passive Programmable Rate and Off, Base Rate (min-1), Rest Rate (min-1), Maximum Tracking Rate (min-1) Delay Parameters Maximum Sensor Rate (min-1), Paced AV Delay (ms), Sensed AV Delay (ms), Rate Responsive AV Delay, Pulse Amplitude (Atrial, RV and LV) (V), Pulse Width (Atrial, RV and LV) (ms), Hysteresis Rate (min-1), Rate Hysteresis with Search Auto Mode Switch (AMS) Off, DDI(R), DDT(R), VVI(R), VVT(R) -1 AMS Detection Rate (min ) 110-300 AMS Base Rate 40, 45, ...135 Auto PMT Detection/Termination A Pace on PMT, Off, Passive Rate Responsive PVARP/VREF Off, Low, Medium, High ™ Ventricular Intrinsic Preference (VIP ) Off, 50-200 (50-150 in increments of 25; 160-200 in increments of 10) ™ ™ LV Cap Confirm, RV Cap Confirm Setup, On, Monitor, Off ACap™ Confirm On, Monitor, Off Cardiac Rhythm Management Stored Electrograms Therapy Summary Episodes Summary Lifetime Diagnostics AT/AF Burden Trend Ventricular HV Lead Impedance Trend Histograms PMT Data Real-Time Measurements (RTM) *LV first with 10 ms interventricular delay. High Voltage Therapy Atrial Fibrillation Post-Shock Pacing Mode Post-Shock Base Rate (min-1) Post-Shock Pacing Duration (min) Cardiac Surgery Cardiology Global Headquarters One Lillehei Plaza St. Paul, Minnesota 55117 USA +1 651 483 2000 +1 651 490 4310 Fax Cardiac Rhythm Management Division 15900 Valley View Court Sylmar, California 91342 USA +1 818 362 6822 +1 818 364 5814 Fax St. Jude Medical Sweden AB Veddestavägen 19 175 84 Järfälla Sweden +46 8 474 4000 +46 8 760 3855 Fax St. Jude Medical Brasil Ltda. Rua Frei Caneca, 1380 7º ao 9º andares 01307-002 - São Paulo (SP) Brazil +55 11 5080 5400 +55 11 5080 5423 Fax St. Jude Medical (Hong Kong) Ltd. Unit 2701-07 27/F, COSCO Tower Grand Millennium Plaza 183 Queen’s Road Central, Hong Kong +852 2996 7688 +852 2956 0622 Fax St. Jude Medical Japan Co., Ltd. 3-1-30, Minami-Aoyama Minato-ku Tokyo 107 0062 Japan +81 3 3423 6450 +81 3 3402 5586 Fax 5 Sperzel J, Meine M et al. A new automatic update function of the morphology template used for SVT/VT discrimination in an ICD. Europace Supplements; Vol. 3, July 2002; A 131, #1515. 6 Summary of Safety and Effectiveness, P88086/S83 and P830015/S76; St. Jude Medical. 7 Sharma AD, O’Neill PG, Fain E et al. Shock on T versus DC for induction of ventricular fibrillation: a randomized prospective comparison. 21st Annual Scientific Session North American Society of Pacing and Electrophysiology (NASPE). Poster presentation published in meeting proceedings. Washington D.C., U.S.A. May 2000. Neuromodulation St. Jude Medical Europe, Inc. The Corporate Village Figueras Building Avenue Da Vinci Iaan, 11 Box F1 B-1935 Zaventem Belgium +32 2 774 68 11 +32 2 772 83 84 Fax sjm.com Brief Summary: Prior to using these devices, please review the Instructions for Use for a complete listing of indications, contraindications, warnings, precautions, potential adverse events and directions for use. Devices depicted may not be available in all countries. Check with your St. Jude Medical representative for product availability in your country. Unless otherwise noted, ™ indicates that the name is a trademark of, or licensed to, St. Jude Medical or one of its subsidiaries. ST. JUDE MEDICAL, the nine-squares symbol and MORE CONTROL. LESS RISK. are trademarks and service marks of St. Jude Medical, Inc. and its related companies. ©2008 St. Jude Medical, Inc. All Rights Reserved. Item No. GMCRM393 Promote Accel™ Cardiac Resynchronisation Therapy Defibrillator (CRT-D) with SJ4 Connector MODEL CD3215-36Q Specifications The SJ4 connector is designed to simplify implants by streamlining defibrillation connections into a single terminal pin and reducing the number of set screws. The SJ4 connection reduces pocket bulk, which may provide increased comfort, particularly for patients who are thin or small in stature, and could lessen the risk of lead-to-can abrasion, a known complication. LV, RV, and Atrial Capture Confirmation features ensure capture of the myocardium in response to pacing stimuli in the left ventricle, right ventricle and right atrium. LVCap™, RVCap™ and ACap™ Confirm help ensure patient safety and therapy delivery by automatically monitoring and adjusting capture thresholds according to changing patient needs. Advanced Biventricular Pacing options. – Triggered Pacing with BiV Trigger Mode helps maintain a high percentage of BiV pacing by triggering pacing in both the left and right ventricles in response to a sensed ventricular event. – VectSelect programmable LV pulse configuration (LV ring-RV coil, LV tip-RV coil or LV bipolar) may be adjusted noninvasively via the programmer. ™ – Negative AV hysteresis with search promotes ventricular pacing by automatically reducing the AV delay when intrinsic activity is present, thereby promoting a high degree of ventricular pacing. DeFT Response™ technology tools provide more clinically proven, non-invasive options for managing high DFTs. – Programmable pulse widths allow the user to tailor the shock to the individual patient, making shocks more efficacious.1 – SVC shocking electrode can be quickly and non-invasively activated or deactivated with the press of a button. – 36 J delivered energy provides unsurpassed energy for defibrillation. – Four programmable tilt options are available to accommodate variances among patients.2 – Together, these features may help to prevent additional surgeries. Exclusive SenseAbility ™ feature, with Decay Delay and Threshold Start, provides the flexibility to fine-tune sensing to individual patient needs and help eliminate oversensing of T waves, fractionated QRS complexes, and other extraneous signals. QuickOpt™ Timing Cycle Optimisation provides quick and effective optimisation for more patients at the push of a button.3 – IEGM-based AV and V-V optimisation allows optimised timing without need for echo-guided optimisation. – V-V timing optimisation may help improve patient outcomes. Because not all patients respond to simultaneous biventricular pacing, programmable timing of right- and left-ventricular outputs helps to ensure appropriate therapy and may reduce the number of non-responders.4 Exclusive Morphology Discrimination plus AV Rate Branch SVT discrimination feature helps reduce the risk of inappropriate ICD shocks and is intended to promote fast, accurate diagnosis and delivery of therapy. Clinical data states that this combination resulted in a sensitivity of 100% with a specificity of 85%.5 Exclusive AF Suppression™ algorithm is clinically proven to suppress episodes of paroxysmal and persistent AF. – Studies show a 25% decrease in symptomatic AF burden.6 AT/AF Alerts notify patients and their clinics when a programmed AT/AF threshold or continuous episode duration has been exceeded, or when a high ventricular rate accompanies the AT/AF episode. Exclusive DC Fibber™ induction has a documented 95,5% success rate for inducing fibrillation on the first induction as compared with a 72,7% success rate for Shock-on-T.7 Exercise Trend Diagnostic provides insight into the patient’s disease state progression and exercise activity. Up to 45 minutes of continuous, fully annotated stored electrograms, including up to 60 seconds of pre-trigger information per electrogram. – Preferential EGM storage capability allows prioritisation of episode storage. Exclusive Vibratory Patient Notifier allows even patients with hearing problems to be alerted to a low battery, lead-related complications and more. Automatic Daily High-Voltage (HV) Lead Integrity Test is designed to automatically test the HV lead on a daily basis to ensure therapy delivery for optimal patient safety. Multiple hardware and software system safeguards for added security and patient comfort. The capability to program multiple ATP schemes per zone has the potential to increase the success of ATP prior to requiring a shock. InvisiLink™ wireless telemetry, in conjunction with the Merlin@home™ transmitter and Merlin.net™ Patient Care Network (PCN), allows for seamless remote monitoring and follow-up. InvisiLink RF telemetry uses a dedicated range of frequencies designated for medical devices called the MICS (Medical Implant Communications Service) frequency band, which helps reduce the interference seen on frequencies used by common household electronics. Indications: The devices are intended to provide ventricular antitachycardia pacing and ventricular defibrillation for automated treatment of life-threatening ventricular arrhythmias. Cardiac Resynchronisation Therapy devices (CRT-Ds) are also intended to resynchronise the right and left ventricles in patients with congestive heart failure. Contraindications: Contraindications for use of the pulse generator system include ventricular tachyarrhythmias resulting from transient or correctable factors such as drug toxicity, electrolyte imbalance, or acute myocardial infarction. Warnings and Precautions: Implantation Procedure. The physician should be familiar with all components of the system and the material in this manual before beginning the procedure. Ensure that a separate standby external defibrillator is immediately available. Implant the pulse generator no deeper than 5 cm to ensure reliable data transmission. For patient comfort, do not implant the pulse generator within 1,25 cm of bone unless you cannot avoid it. Device Replacement. Replace the pulse generator within three months of reaching the 2,45 V indication. Replace the pulse generator immediately upon reaching 2,45 V if there is frequent high-voltage charging and/or one or more of the pacing outputs are programmed above 2,5 V. Battery Incineration. Do not incinerate pulse generators as they contain sealed chemical power cells and capacitors that may explode. Return explanted devices to St. Jude Medical. High-Voltage Can. Ensure that tachyarrhythmia therapy is programmed Off before handling the pulse generator to avoid any risk of accidental shock. Do not program tachyarrhythmia therapies On until the pulse generator is inserted in the pocket. For effective defibrillation, perform all defibrillation testing with the can in the pocket. Magnetic Resonance Imaging (MRI). Avoid MRI devices because of the magnitude of the magnetic fields and the strength of the radiofrequency (RF) fields they produce. Device Storage. Store the pulse generator at temperatures between 10° and 45°C. Do not subject it to temperatures below -20° or over 60°C. After cold storage, allow the device to reach room temperature before charging the capacitors, programming, or implanting the device because cold temperature may affect initial device function. Device Communication. Communication with the device can be affected by electrical interference and strong magnetic fields. If this is a problem, turn off nearby electrical equipment or move it away from the patient and the programmer. If the problem persists, contact St. Jude Medical. Lead Impedance. Do not implant the pulse generator if the acute defibrillation lead impedance is less than 20 ohms or the lead impedance of chronic leads is less than 15 ohms. Damage to the device may result if high-voltage therapy is delivered into an impedance less than 15 ohms. Suboptimal RF Communication. The Merlin™ PCS indicates the quality of the RF communication by the telemetry strength indicator LEDs on both the programmer and the Merlin Antenna. Disconnecting Leads. Connecting or disconnecting sense/pace leads can produce electrical artifacts that can be sensed by the pulse generator. To prevent detection of artifacts, reprogram the pulse generator to tachyarrhythmia therapy Off: Before disconnecting the leads from a pulse generator in the operating room; Before a post-mortem examination; Whenever there are no leads connected to it; When sense/pace leads are connected but are not implanted in a patient. If a programmer is not available, use a magnet to prevent delivery of tachyarrhythmia therapy in response to detected disconnection artifacts. Place the magnet over the pulse generator before disconnecting the leads. Do not remove it until the leads are reconnected. External Equipment for Arrhythmia Induction. If external equipment is used for arrhythmia induction through the pulse generator header and leads, apply rectified AC current through the high-voltage ports, not the sense/pace ports, to avoid damaging the sense/pace function: disconnect the external equipment from the pulse generator before any therapy is delivered; otherwise, damage to the device is likely to occur. Place a magnet over the device until the external equipment can be disconnected. Adverse Events: Implantation of the pulse generator system, like that of any other device, involves risks, some possibly life-threatening. These include but are not limited to the following: acute hemorrhage/bleeding, air emboli, arrhythmia acceleration, cardiac or venous perforation, cardiogenic shock, cyst formation, erosion, exacerbation of heart failure, extrusion, fibrotic tissue growth, fluid accumulation, hematoma formation, histotoxic reactions, infection, keloid formation, myocardial irritability, nerve damage, pneumothorax, thromboemboli, venous occlusion. Other possible adverse effects include mortality due to: component failure, device-programmer communication failure, lead abrasion, lead dislodgment or poor lead placement, lead fracture, inability to defibrillate, inhibited therapy for a ventricular tachycardia, interruption of function due to electrical or magnetic interference, shunting of energy from defibrillation paddles, system failure due to ionising radiation. Other possible adverse effects include mortality due to inappropriate delivery of therapy caused by: multiple counting of cardiac events including T waves, P waves, or supplemental pacemaker stimuli. Among the psychological effects of device implantation are imagined pulsing, dependency, fear of inappropriate pulsing, and fear of losing pulse capability. Refer to the User’s Manual for detailed indications, contraindications, warnings, precautions and potential adverse events. Post-Therapy Pacing (Independently programmable from Bradycardia and ATP ) PHYSICAL SPECIFICATIONS Post-Shock Pacing Mode Post-Shock Base Rate (min-1) Post-Shock Pacing Duration (min) Models Telemetry Delivered Energy (J) Volume (cc) Weight (g) Size (mm) Defibrillation Lead Connections Sense/Pace Lead Connections High Voltage Can PARAMETER CD3215-36Q RF 36 42 82 75 x 50 x 14 SJ4 IS-1; SJ4 Electrically active titanium can V. Triggering (BiV Trigger Mode) QuickOpt™ Timing Cycle Optimisation V-V Timing Interventricular Pace Delay (ms) Ventricular Sensing Ventricular Pacing Chamber Negative AV Hysteresis/Search (ms) Shortest AV Delay (ms) VectSelect™ LV Pulse Configuration On; Off Sensed/paced AV delay; Interventricular Pace delay Simultaneous*; RV First; LV First RV First 10-80 / LV First 15-80 in increments of 5 RV only (not programmable) RV only; biventricular Off; -10 to -120 25-120 LV tip to RV coil; LV bipolar; LV ring to RV coil Off; AAI; VVI; DDI; or DDD 30-100 in increments of 5 Off; 0,5; 1; 2,5; 5; 7,5; or 10 Device Testing/Induction Methods DC Fibber™ Pulse Duration (sec) Burst Fibber Cycle Length (ms) Noninvasive Programmed Stimulation (NIPS) 0,5-5,0 20-100 2-25 stimuli with up to three extrastimuli Patient Notifiers Settings Programmable Notifiers (On, Off) Device Parameter Reset Entry into Backup VVI Mode Vibration Duration (sec) Number of Vibrations per Notification Number of Notifications Time Between Notifications (hours) Device at ERI; Charge Time Limit Reached; Possible HV Circuit Damage; Atrial Lead Impedance Out of Range; RV Lead Impedance Out of Range; LV Lead Impedance Out of Range; High-Voltage Lead Impedance Out of Range; AT/AF Burden On On 2; 4; 6; 8; 10; 12; 14; 16 2 1-16 10; 22 AF Management AF Suppression™ Pacing No. of Overdrive Pacing Cycles Maximum AF Suppression Rate Electrograms and Diagnostics On; Off 15-40 in steps of 5 80-150 min-1 Sensing/Detection SenseAbility™ Technology Threshold Start Decay Delay Ventricular Sense Refractory (ms) Detection Zones SVT Discriminators Reconfirmation Automatic Sensitivity Control adjustment for atrial and ventricular events (Post-Sensed; Atrial) 50; 62,5; 75; 100%; (Post-Paced, Atrial) 0,2-3,0 mV; (Post-Sensed; Ventricular) 50; 62,5; 75; 100%; (Post-Paced; Ventricular) Auto; 0,2-3,0 mV (Post-Sense/Post-Pace; Atrial/Ventricular) 0-220 125; 157 VT-1; VT-2; VF AV Rate Branch; Sudden Onset; Interval Stability; Morphology Discrimination (MD) with Manual or Automatic Template Update Continuous sensing during charging Antitachycardia Pacing Therapy ATP Configurations Burst Cycle Length Min. Burst Cycle Length (ms) Number of Bursts/Stimuli Add Stimuli per Burst Ramp; Burst; Scan; 1 or 2 schemes per zone Adaptive; Readaptive or Fixed 150-400 in increments of 5 1-15 with 2-20 Stimuli On; Off 1 Mouchawar G, Kroll M, Val-Mejias JE et al. ICD waveform optimization: a randomized prospective, pair-sampled multicenter study. PACE 2000; 23 (Part II):1992-1995. 2 Sweeney MO, Natale A, Volosin KJ et al. Prospective randomized comparison of 50%/50% versus 65%/65% tilt biphasic waveform on defibrillation in humans. PACE 2001; 24:60-65. Fixed Pulse Width; Fixed Tilt Biphasic; Monophasic Cathode (-); Anode (+) RV to Can; RV to SVC/Can 3 Baker et al. Acute evaluation of programmer-guided AV/PV and VV delay optimization comparing an IEGM method and echocardiogram for cardiac resynchronization therapy in heart failure patients and dual-chamber ICD implants. Journal of Cardiovascular Electrophysiology, Vol. 18 No. 2, Feb. 2007. Bradycardia Pacing Permanent Modes Off; DDD(R); DDT(R); DDI(R); VVT(R); VVI(R); AAI(R) Temporary Modes Off; DDD(R); DDT(R); DDI(R); VVT(R); VVI(R); AAI(R); AAT; DOO; VOO; AOO Rate-Adaptive Sensor On; Off; Passive Programmable Rate and Off; Base Rate (min-1); Rest Rate (min-1); Maximum Tracking Rate (min-1) Delay Parameters Maximum Sensor Rate (min-1); Paced AV Delay (ms); Sensed AV Delay (ms); Rate Responsive AV Delay; Pulse Amplitude (Atrial; RV and LV) (V); Pulse Width (Atrial; RV and LV) (ms); Hysteresis Rate (min-1); Rate Hysteresis with Search Auto Mode Switch (AMS) Off; DDI(R); DDT(R); VVI(R); VVT(R) -1 AMS Detection Rate (min ) 110-300 Atrial Tachycardia Base Rate 40; 45; ...135 Auto PMT Detection/Termination A Pace on PMT; Off; Passive Rate Responsive PVARP/VREF Off; Low; Medium; High ™ Ventricular Intrinsic Preference (VIP ) Off; 50-200 (50-150 in increments of 25; 160-200 in increments of 10) ™ ™ LV Cap Confirm, RV Cap Confirm Setup; On; Monitor; Off ACap™ Confirm On; Monitor; Off Atrial Fibrillation Cardiac Rhythm Management Up to 45 minutes including up to one minute programmable pre-trigger data per VT/VF diagnosis/detection electrograms; triggers include diagnosis; therapy; atrial episode; PMT termination; PC shock delivery; noise reversion; magnet reversion; and morphology template verification Diagram of therapies delivered Directory listing of up to 60 episodes with access to more details including stored electrograms History of bradycardia events and device-initiated charging Trend data and counts Multi-Vector Trend Data Event Histogram; AV Interval Histogram; Mode Switch Duration Histogram; Peak Filtered Rate Histogram; Atrial Heart Rate Histogram; Ventricular Heart Rate Histogram; AT/AF Burden; Exercise and Activity Trending; V Rates During AMS Information regarding PMT detections Pacing lead impedances; high voltage lead impedances; unloaded battery voltage; and signal amplitudes *LV first with 10 ms interventricular delay. High-Voltage Therapy High-Voltage Output Mode Waveform RV Polarity Electrode Configuration Stored Electrograms Therapy Summary Episodes Summary Lifetime Diagnostics AT/AF Burden Trend Ventricular HV Lead Impedance Trend Histograms PMT Data Real-Time Measurements (RTM) Cardiac Surgery Cardiology Global Headquarters One Lillehei Plaza St. Paul, Minnesota 55117 USA +1 651 483 2000 +1 651 490 4310 Fax Cardiac Rhythm Management Division 15900 Valley View Court Sylmar, California 91342 USA +1 818 362 6822 +1 818 364 5814 Fax St. Jude Medical Sweden AB Veddestavägen 19 175 84 Järfälla Sweden +46 8 474 40 00 +46 8 760 95 42 Fax St. Jude Medical Coordination Center BVBA The Corporate Village Da Vincilaan 11 Box F1 1935 Zaventem Belgium +32 2 774 68 11 +32 2 772 83 84 Fax St. Jude Medical Brasil Ltda. Rua Frei Caneca, 1380 7º ao 9º andares 01307-002 - São Paulo (SP) Brazil +55 11 5080 5400 +55 11 5080 5423 Fax St. Jude Medical (Hong Kong) Ltd. Unit 2701-07 27/F, COSCO Tower Grand Millennium Plaza 183 Queen’s Road Central, Hong Kong +852 2996 7688 +852 2956 0622 Fax 4 Chan et al. Tissue Doppler guided optimization of A-V and V-V delay of biventricular pacemaker improves response to cardiac resynchronization therapy in heart failure patients. J Cardiac Failure 2004; 10:4 (supplement): 572 (abstract 199). 5 Sperzel J, Meine M et al. A new automatic update function of the morphology template used for SVT/VT discrimination in an ICD. Europace Supplements; Vol. 3, July 2002; A 131, #1515. 6 Carlson MD et al. A new pacemaker algorithm for the treatment of atrial fibrillation: results of the Atrial Dynamic Overdrive Pacing Trial (ADOPT). JACC 2003; 42:627-633. 7 Sharma AD, O’Neill PG, Fain E et al. Shock on T versus DC for induction of ventricular fibrillation: a randomized prospective comparison. 21st Annual Scientific Session North American Society of Pacing and Electrophysiology (NASPE). Poster presentation published in meeting proceedings. Washington D.C., U.S.A. May 2000. Neuromodulation St. Jude Medical Japan Co., Ltd. 3-1-30, Minami-Aoyama Minato-ku Tokyo 107 0062 Japan +81 3 3423 6450 +81 3 3402 5586 Fax sjm.com Brief Summary: Prior to using these devices, please review the Instructions for Use for a complete listing of indications, contraindications, warnings, precautions, potential adverse events and directions for use. Devices depicted may not be available in all countries. Check with your St. Jude Medical representative for product availability in your country. Unless otherwise noted, ™ indicates that the name is a trademark of, or licensed to, St. Jude Medical or one of its subsidiaries. ST. JUDE MEDICAL, the nine-squares symbol and MORE CONTROL. LESS RISK. are trademarks and service marks of St. Jude Medical, Inc. and its related companies. ©2009 St. Jude Medical, Inc. All Rights Reserved. Item No. GMCRM453