Principal Investigator/Program Director (Last, First, Middle):
BIOGRAPHICAL SKETCH
Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.
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NAME
POSITION TITLE
Horacio Kaufmann, M.D.
eRA COMMONS USER NAME
Professor of Neurology, Medicine and Pediatrics
HKAUFMANN
EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)
INSTITUTION AND LOCATION
DEGREE
(if applicable)
YEAR(s)
B.S
1972
Biology
M.D.
1978
Medicine
Colegio Nacional de Buenos Aires, Buenos
Aires Argentina
Facultad de Medicina, Universidad Nacional
de Buenos Aires, Argentina
FIELD OF STUDY
POSTGRADUATE TRAINING EXPERIENCE AND ACADEMIC APPOINTMENTS
1979-1982
1982-1985
1985-1986
1986-1987
1989-1991
1994-2000
1987-2007
1987-1995
1995-2003
2003-2007
2004-2007
2007- present
2007- present
2007- present
2007- present
2007-present
Resident, Internal Medicine. CEMIC, Buenos Aires, Argentina.
Resident, Department of Neurology, Mount Sinai School of Medicine, New York, NY
Fellow, Autonomic Disorders, Department of Neurology, Mount Sinai School of Medicine, New York, NY
Instructor, Department of Neurology, Mount Sinai School of Medicine, New York, NY
Director, Parkinson’s Disease Clinic, Mount Sinai Medical Center, New York, NY
Director, Neurology Clinic, Mount Sinai Medical Center, New York, NY
Director, Autonomic Nervous System Laboratory Mount Sinai School of Medicine, New York, NY
Assistant Professor of Neurology, Mount Sinai School of Medicine, New York, NY
Associate Professor of Neurology, Mount Sinai School of Medicine, NewYork, NY
Professor of Neurology, Mount Sinai School of Medicine, NewYork, NY
Alex and Shirley Aidekman Neurological Research Chair, New York, NY
Professor of Neurology, New York University School of Medicine, New York, NY
Professor of Medicine, New York University School of Medicine, New York, NY
Professor of Pediatrics, New York University School of Medicine, New York, NY
Director, Dysautonomia Center, NYU Medical Center, New York, NY
F.B. Axelrod Professor of Dysautonomia Research, NYU School of Medicine, New York, NY
CERTIFICATION
1987
Diplomate, American Board of Psychiatry and Neurology (N), Certificate #29827
PROFESSIONAL SOCIETIES / EDITORIAL BOARDS
1993-1995
1993-1997
1997-2003
1997-2004
2000-present
2002-2006
2002-2006
2005-2006
Chairman, American Academy of Neurology, Section of the Autonomic Nervous System
Secretary, World Federation of Neurology, Research Group on the Autonomic Nervous System
Chairman, World Federation of Neurology, Research Group on the Autonomic Nervous System
Board of Directors, American Autonomic Society
Editor in Chief, Clinical Autonomic Research
Editorial Board, Journal of Neural Transmission
Editorial Board, Parkinsonism and Related Disorders
President, American Autonomic Society
SELECTED PEER REVIEW PUBLICATIONS
1.
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Kaufmann H, Elijovich F and Yahr MD. An unusual cause of tetany: surreptitious use of furosemide. Mt Sinai J Med
1984; 51:625-628.
Brannan T, Weinberger J, Knott P, Taff I, Kaufmann H, Togasaki D, Nieves-Rosa J. and Maker H. Direct evidence of
acute, massive striatal dopamine release in gerbils with unilateral strokes. Stroke 1987; 18:108-110.
Kaufmann H, Brannan T, Krakoff L, Mandelli J and Yahr MD. Treatment of orthostatic hypotension due to autonomic
failure with a peripheral alpha adrenergic agonist (midodrine). Neurology 1988; 38:951-956.
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Brannan T, Knott PJ, Kaufmann H, Leung L and Yahr MD. Microdialysis monitoring of dopamine release and
metabolism in response to L-DOPA. J Neural Transm 1989; 75:149-157.
Kaufmann H, Oribe E, Pierotti AR, Roberts JL and Yahr MD. Atrial natriuretic factor in human autonomic failure.
Neurology 1990; 40:1115-1119.
Kaufmann H, Oribe E and Yahr MD. Differential effect of L-threo-3, 4-dihydroxy-phenylserine in pure autonomic
failure and multiple system atrophy with autonomic failure. J Neural Transm 1991; 3:143-148.
Kaufmann H, Oribe E and Oliver J. Plasma endothelin during upright tilt: relevance for orthostatic hypotension. Lancet
1991; 338:1542-45.
Kaufmann H, Oribe E, Miller M, Knott P, Wiltshire-clement M and Yahr MD. Hypotension induced vasopressin release
distinguishes between pure autonomic failure and multiple system atrophy with autonomic failure. Neurology 1992;
42:590-93.
Simpson D, Kaufmann H, Sanders I and Wolfe D. Laryngeal dystonia in multiple system atrophy. Muscle and Nerve
1992:1213-15.
Jankovic J, Gilden JL, Hiner BC, Kaufmann H, Brown DC, Coghlan CH, Rubin M and Fouad-Tarazi FM. Neurogenic
orthostatic hypotension: a double-blind placebo-controlled study with midodrine. Am J Med 1993; 95:38-48.
Kaufmann H. Head up tilt, lower body negative pressure, pacemakers and vasovagal syncope. Clin Auton Res 1994,
4:231-232.
Kaufmann H. Neurally Mediated Syncope: pathogenesis, diagnosis and treatment. Neurology 1995; 45:S12-18.
Perera R and Kaufmann H. Effect of recombinant erythropoietin on anemia and orthostatic hypotension in primary
autonomic failure. Clin Auton Res 1995; 5:211-3.
Schatz IJ, Bannister R, Freeman RL, Goetz CG, Jankovic J, Kaufmann HC, Koller WC, Low PA, Mathias CJ, Polinsky
RJ, Quinn NP, Robertson D and Streeten DHP. Consensus statement on the definition of orthostatic hypotension, pure
autonomic failure, and multiple system atrophy. Neurology 1996; 46:1470.
Kaufmann H. Could DOPS do for autonomic failure what DOPA did for Parkinson’s disease? Neurology 1996;
47:1370-1371.
Oribe E, Winters S, Gomes JA and Kaufmann H. Syncope: the diagnostic value of head up tilt testing. Pace 1997;
20:874-879.
Hague K, Lento P, Morgello S and Kaufmann H. The distribution of Lewy bodies in pure autonomic failure: autopsy
findings and review of the literature. Acta Neuropathologica 1997; 94:192-196.
Kaufmann H. Neurally mediated syncope and syncope due to autonomic failure: differences and similarities. J of Clin
Neurophysiol 1997; 14:183-196.
Kaufmann H. Syncope: a neurologist’s viewpoint. Cardiol Clinics 1997; 15:177-193.
Biaggioni I, Costa F and Kaufmann H. Vestibular influences on autonomic cardiovascular control in humans. J Vest
Res 1998; 8:35-41.
Gilman S, Low PA, Quinn N, Albanese A, Ben-Shlomo Y, Fowler CJ and Kaufmann H, et al. Consensus Statement on
the Diagnosis of Multiple System Atrophy. Journal of the Autonomic Nervous System 1998; 74:189-192.
Olanow CW, Koller WC, Aminoff MJ, Berchou RC, Carter JH, Kaufmann H, Lieberman A, Nutt JG, O’Brien CF, Stern
MB, Stocchi F, Waters C, Watts RL and Welsh MD. An algorithm (decision tree) for the management of Parkinson’s
disease: Treatment guidelines. Neurology 1998; 50(suppl 3):S1-S57.
Wright RA, Kaufmann H, Perera R, Opfer-Gehrking TL, McElligott, Sheng KN and Low PA. A double-blind, doseresponse study of midodrine in neurogenic orthostatic hypotension. Neurology 1998; 51:120-124.
Kaufmann H. Multiple system atrophy. Current Opinion in Neurology 1998; 11:351-355.
Dai M, Kaufmann H, Raphan T and Cohen B. Promethazine affects optokinetic but not vestibular responses in monkeys.
Aviation, Space, and Environmental Medicine 2000; 71:1003-1012.
Vagaonescu TD, Saadia D, Tuhrim S, Phillips RA and Kaufmann H. Hypertensive cardiovascular damage in patients
with primary autonomic failure. Lancet 2000; 355:725-726.
Kaufmann H. Primary autonomic failure: three clinical presentations of one disease. Annals of Internal Medicine 2000;
133:382-384.
Voustianiouk A and Kaufmann H. Magnetic fields and the central nervous system. Clinical Neurophysiology 2000;
111:1934-1935.
Kaufmann H, Hague K and Perl D. Accumulation of alpha synuclein in autonomic nerves in pure autonomic failure.
Neurology 2001; 56:980-981.
Saadia D, Voustianiouk A, Wang A and Kaufmann H. Botulinum toxin type A in primary palmar hyperhidrosis: a
randomized, single-blind, two-dose study. Neurology 2001; 57:2095-2099.
Horowitz DR and Kaufmann H. Autoregulatory cerebral vasodilation occurs during orthostatic hypotension in patients
with primary autonomic failure. Clin Auton Res 2001; 11; 363-368.
Kaufmann H and Hainsworth R. Why do we faint? Muscle and Nerve 2001; 24(8):981-983.
Kaufmann H, Biaggioni I, Voustianiouk A, Diedrich A, Costa F, Clarke R, Gizzi M Raphan T, and Cohen B. Vestibular
control of sympathetic activity: an otolith-sympathetic reflex in humans. Exp Brain Research (2002) 143:463-469.
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Principal Investigator/Program Director (Last, First, Middle):
34. Kaufmann H and Bhattacharya K. Syncope. The Neurologist 2002 8: 175-185.
35. Bhattacharya K, Saadia D, Eisenkraft B, Yahr M, Olanow W, Drayer B and Kaufmann H. Brain magnetic resonance
imaging in multiple system atrophy and Parkinson’s disease: A diagnostic algorithm. Arch Neurol 2002; 59:835-842.
36. Bhattacharya KF, Velickovic M, Schilsky M and Kaufmann H. Cardiovascular autonomic reflexes in Wilson’s disease.
Clin Auton Res 2002 Jun;12(3):190-2.
37. Gutierrez J, Santiesteban R, Garcia H, Voustianiouk A, Freeman R and Kaufmann H. High blood pressure and
decreased heart rate variability in the Cuban epidemic neuropathy. J Neurol Neurosurg Psychiatry 2002; 73(1):71-2.
38. Kaufmann, H. Management of orthostatic hypotension. Clin Neuropharm 2002; 25(3):133-41.
39. Kaufmann H, Saadia D, Voustianiouk A. Midodrine in neurally mediated syncope: A double-blind, randomized,
crossover study. Ann Neurol 2002;52(3):342-5.
40. Kaufmann H, Bhattacharya KF, Voustianiouk A, Gracies JM. High frequency stimulation of the subthalamic nucleus
increases heart rate in patients with Parkinson disease. Neurology 2002 26;59(10):1657-8.
41. Kaufmann H. Intolerancia ortostática y síncope. Rev Neurol 2003 Jan 1-15; 36: 75-9.
42. Kaufmann H. Disautonomías más comunes. Rev Neurol 2003 Jan 1-15; 36: 93-6.
43. Kaufmann H, Saadia D, Polin C, Hague S, Singleton A, Singleton. Primary hyperhidrosis. Evidence for autosomal
dominant inheritance. Clin Auton Res 2003 Apr; 13(2): 96-8.
44. Kaufmann H, Saadia D, Voustianiouk A, Goldstein DS, Holmes C, Yahr MD, Nardin R, Freeman R. Norepinephrine
precursor therapy in neurogenic orthostatic hypotension. Circulation 2003; 108:724-728.
45. Bhattacharya KF, Nouri S, Olanow CW, Yahr MD, Kaufmann H. Selegiline in Parkinson disease: its impact on
orthostatic hypotension. Parkinsonism and Related Disorders 2003 Mar; 9(4): 221-4.
46. Kaufmann H, Biaggioni I. Autonomic failure in neurodegenerative disorders. Seminars in Neurology 2003; 23(4):351363.
47. Kaufmann H, Nahm K, Purohit D, Wolfe D. Autonomic failure as the initial presentation of Parkinson disease and
dementia with Lewy bodies. Neurology. 2004 Sep 28;63(6):1093-5.
48. Thijs RD, Wieling W, Kaufmann H, van Dijk JG. Defining and classifying syncope. Clin Auton Res. 2004 Oct; 14 Suppl
1:4-8.
49. Colman N, Nahm K, Ganzaeboom KS, Shen WK, Reitsma J, Linzer M, Wieling W, Kaufmann H. Epidemiology of
reflex sycope. Clin Auton Res. 2004 Oct; 14 Suppl 1:9-17.
50. Colman N, Nahm K, van Dijk JG, Reitsma JB, Wieling W, Kaufmann H. Diagnostic value of history taking in reflex
syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:37-44.
51. Kaufmann H, Freeman R. Pharmacological treatment of reflex syncope. Clin Auton Res. 2004 Oct; 14 Suppl 1:71-75.
52. Kaufmann H, Wieling W. Syncope: a clinically guided algorithm. Clin Auton Res. 2004 Oct; 14 Suppl 1: 87-90.
53. Moore ST, Diedrich A, Biaggioni I, Kaufmann H, Raphan T, Cohen B. Artificial gravity: a possible countermeasure for
post-flight orthostatic intolerance. Acta Astronaut. 2005 May-Jun;56(9-12):867-76.
54. Gibbons CH, Vernino SA, Kaufmann H, Freeman R. L-DOPS therapy for refractory orthostatic hypotension in
autoimmune autonomic neuropathy. Neurology. 2005 Oct 11;65(7):1104-6.
55. Idiaquez J, Kaufmann H, Soza M, Necochea C. Pure autonomic failure. Bradbury Eggleston Syndrome. Rev Med Chil.
2005 Feb;133(2):215-8.
56. Voustianiouk A, Kaufmann H, Diedrich A, Raphan T, Biaggioni I, Macdougall H, Ogorodnikov D, Cohen B. Electrical
activation of the human vestibulo-sympathetic reflex. Exp Brain Res. 2006 May;171(2):251-61.
57. Cheshire W, Nahm K, Benarroch E, Kaufmann H. Dopamine ß-hydroxylase deficiency involves the central autonomic
network. Acta Neuropathologica 2006 Aug;112(2):227-9.
58. Norcliffe-Kaufmann LJ, Kaufmann H, Hainsworth R. (2008) Enhanced vascular responses to hypocapnia in neurally
mediated syncope. Annals of Neurol. 63 (3): 288-94.
59. Kaufmann H. L-dihydroxyphenylserine (Droxidopa): a new therapy for neurogenic orthostatic hypotension: the US
experience. Clin Auton Res. 2008 Mar; 18 (Suppl.1):19-24.
60. Garakani A, Martinez JM, Aaronson CJ, Vousitaniouk A, Kaufmann H, Gorman JM. Effect of medication and
psychotherapy on heart rate variability in panic disorder. Depress Anxiety. 2008 Oct 6 [ePub ahead of print].
Research Funding, Recently completed and ongoing
Grant (PI)
Funding Agency/Sponsor
Title and Description
Duration
Direct/year
% Effort
Total Direct
RO1 DC04212 (Kaufmann)
8/1/00-7/31/06
40%
NIH
Direct $354,000
$1,400,000
Vestibular Influences on Autonomic Cardiovascular Control
The goal of this project is to study the interaction between the otoliths and the autonomic nervous system. In particular,
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Principal Investigator/Program Director (Last, First, Middle):
the aim is to test the hypothesis that the otoliths, when activated by gravity during standing, initiate a sympathetic
vasoconstrictor reflex that helps maintain upright posture.
RO1 DC007847-01A1 (Dai)
8/1/07-8/1/12
6%
NIH
Direct 250,000
1,250,000
Neural Mechanisms Of Motion Sickness
The goals of this project are to provide new therapeutic approaches for reducing motion sickness sensitivity.
Non federal grant (Kaufmann)
7/1/08-7/1/09
Dysautonomia Foundation Inc
Direct 400,000
Autonomic Dysfunction in familial and non familial dysautonomia
The goals of this project are to provide new therapeutic approaches for dysautomias.
PHS 398/2590 (Rev. 09/04)
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400,000
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