Product Name
CAS No.
KE No.
UN No.
EU No.
ExiPrepTM His-tagged Protein purification kit
Buffer Cartridge
1. Chemical and Manufacturer Information
A. Product Name
B. Recommended Usage and Limitations
Recommended Usage
Limitations of Usage
C. Manufacturer/Supplier/Distributor Information
Company Name
Address
Emergency Contact Number
2. Risks·Hazards
A. Risk·Hazard Classification
Buffer Cartridge
This product is designed for Protein extraction from various samples
using the automated extraction equipment ExiPrep. Product is used
for purification of 6X Histidine tagged protein.
This product is designed for the purpose of purification protein.
Product users must be certified for Purification protein handling or
trained in molecular biological experimental methods.
Bioneer Corporation
Daedeok-gu Munpyeong-dong 49-3, Daejeon, South Korea
+82-42-930-8648
Flammable liquids : Category 2
Corrosive to metal : Category 1
Skin corrosion / skin irritation : Category 2
Severe Eye Damage / Eye Irritation : Category 1
carcinogenic : Category 1A
Reproductive Cell Mutation Properties : Category 1B
Reproductive Toxicity : Category 1A
Target Organ Toxicity (Single Exposure): Category 3(Respiratory
irritation)
Target Organ Toxicity (Single Exposure): Category 3(Acting
anesthetic)
Target Organ Toxicity (Repeat Exposure) : Category 1
B. Caution Items Including Preventative Measures
Warning Symbols
Warning Phrase
Risk·Hazard Phrase
Preventative Measure Phrases
Prevention
Danger
H225 Highly flammable liquid and vapour.
H290 May be corrosive to metals.
H315 Causes skin irritation.
H318 Causes serious eye damage.
H335 May cause respiratory irritation.
H336 May cause drowsiness or dizziness.
H340 May cause genetic defects.
H350 May cause cancer.
H360 May damage fertility or the unborn child.
H372 Causes damage to organs through prolonged or repeated
exposure.
P201 Obtain special instructions before use
P202 Do not handle until all safety precautions have been read
understands.
P210 Keep away from heat/sparks/open flames/hot surfaces. - No
smoking.
P233
P234
P240
P241
P242
P243
P260
P261
P264
P270
P271
P280
Response
Storage
Disposal
Keep container tightly closed.
Keep only in original container.
Ground/bond container and receiving equipment.
Use explosion-proof electrical/ventilating/lighting/equipment.
Use only non-sparking tools.
Take precautionary measures against static discharge.
Do not breathes dust/fume/gas/mist/vapours/spray.
Avoid breathing dust/fume/gas/mist/vapours/spray.
Wash hands thoroughly after handling.
Do not eat, drink or smoke when using this product.
Use only outdoors or in a well-ventilated area.
Wear protective glove/protective clothing/eye protection/face
protection.
P281 Use personal protective equipment as required.
P302+P352 IF ON SKIN: Gently wash with plenty of soap and water.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off immediately
all contaminated clothing. Rinse skin with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and keep at rest
in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several
minutes. Remove contact lenses, if present and easy to do.
Continue rinsing.
P308+P313 IF exposed or concerned: Get medical advice/ attention.
P310 Immediate medical examination Seek.
P312 Call a POISON CENTER or doctor/physician you feel unwell.
P314 Get medical advice/attention if you feel unwell.
P321 Emergency treatment.
P332+P313 If skin irritation occurs: Get medical advice/ attention.
P362 Take off contaminated clothing and wash before reuse.
P370+P378 In case of fire: Use alcohol-resistant form, Dry powder
extinguishing agent, Carbon Dioxide for extinction.
P390 Absorb spillage to prevent material damage.
P403+P233 Store in a well-ventilated place. Keep container tightly
closed.
P403+P235 Store in a well-ventilated place. Keep cool.
P405 Store locked up.
P406 Store in corrosive resistant/… container with a resistant inner
liner.
P501 Dispose of contents/container to …
C. Other Risks·Hazards Not Included in Risk·Hazard Classification (NFPA)
Imidazole
Health
3
Fire
1
Reactivity
0
Sodium Chloride
Health
1
Fire
0
Reactivity
0
Tris (hydroxymethyl) aminomethane
Health
2
Fire
1
Reactivity
0
Ethanol
Health
2
Fire
3
Reactivity
0
3. Ingredient Information
Ingredient Name
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Other Name
Sodium Chloride
2-Amino-2-hydroxymethyl-propane-1,3-diol
Glyoxaline
Ethanol
CAS No.
7647-14-5
77-86-1
288-32-4
64-17-5
% of Total
2.9
0.6
3.2
20
4. First-Aid Measures
A. Upon Eye Contact
B. Upon Skin Contact
C. Upon Inhalation
D. Upon Ingestion
E. Other Cautions
5. Explosion·Fire Measures
A. Proper(Improper) Extinguishing Material
Proper(Improper) Extinguishing Material
B. Specific Hazards from Chemicals
Specific Hazards from Chemicals
C. Firefighting Protection and Precautions
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Flush eyes with water for several minutes. Remove contact lenses if
possible.
Seek emergency medical attention.
Remove contaminated clothing upon contact with skin (or hair)
Shower/wash skin.
Seek medical attention if you feel irritation.
Remove contaminated clothing and shoes, and quarantine the
contaminated region
In case of minor exposure, prevent further spread of contamination.
Remove contaminated clothing upon contact with skin (or hair)
Shower/wash skin.
Seek medical attention if you feel irritation.
For burns, cool the affected area with cold water as long as possible,
and do not remove clothing that has bound to skin.
Wash skin with soap and water.
Immediate medical advice Seek.
If exposed to excessive dust or hyume, remove by clean air and when
you cough or other symptoms, please seek medical attention.
Seek medical attention if exposure or contact is suspected.
If ingestion or inhalation is suspected, do not perform mouth-tomouth resuscitation but use a medical breathing device.
Contact medical service upon exposure and perform emergency
measures such as source analysis.
Inform medical staff of substance and take all precautionary
protection measures.
To extinguish fire related to this material, use alcohol foam, carbon
dioxide or water spraying.
Use dry sand or earth for fire suppression
Highly flammable liquid and vapor
May cause corrosion metals
May cause fire and explosion from extreme polymerization
Vapor may cause ignition when near ignition source
Toxic gases may form during heat decomposition or combustion.
May form explosive mixture near and above ignition point.
Container may explode upon heating.
Highly flammable: Easily ignited with heat, sparks or flames.
Leaks may lead to fire/explosions
Vapor explosion hazard indoors, outdoors and in sewers.
Portions may burn but will not ignite easily.
May form explosive mixture when vapor is mixed with air.
Non-volatile. The chemical itself does not burn but heating may
disintegrate and form corrosive/toxic fumes.
Rescuers must wear appropriate protection.
Maintain a safe distance when extinguishing flames.
May be transported when melted.
Dig a trough to contain the spread of extinguished fluid.
Remove container if conditions are not hazardous.
For tank fires, extinguish at maximum distance or with unmanned
extinguishing devices.
For tank fires, cool the container with excess water even after fire is
extinguished.
During tank fires, if a high pitched sound emits from the pressure
release valve or the tank becomes discolored, retreat immediately.
During tank fires, retreat from a tank consumed in flames.
During tank fires, if the fire is large-scale, use an unmanned
extinguishing device or retreat and let the fire burn.
Rescuers must wear appropriate protection.
Maintain a safe distance when extinguishing flames.
May be transported when melted.
Imidazole
Ethyl alcohol
6. Accidental Release Measures
A. Measures and Protection for Personal
Protection
B. Measures for Environmental Protection
C. Claining and Removal Measures
Dig a trough to contain the spread of extinguished fluid.
Remove container if conditions are not hazardous.
For tank fires, extinguish at maximum distance or with unmanned
extinguishing devices.
For tank fires, cool the container with excess water even after fire is
extinguished.
During tank fires, if a high pitched sound emits from the pressure
release valve or the tank becomes discolored, retreat immediately.
During tank fires, retreat from a tank consumed in flames.
During tank fires, if the fire is large-scale, use an unmanned
extinguishing device or retreat and let the fire burn.
Rescuers must wear appropriate protection.
Maintain a safe distance when extinguishing flames.
Dig a trough to contain the spread of extinguished fluid.
Remove container if conditions are not hazardous.
For tank fires, extinguish at maximum distance or with unmanned
extinguishing devices.
For tank fires, cool the container with excess water even after fire is
extinguished.
During tank fires, if a high pitched sound emits from the pressure
release valve or the tank becomes discolored, retreat immediately.
During tank fires, retreat from a tank consumed in flames.
During tank fires, if the fire is large-scale, use an unmanned
extinguishing device or retreat and let the fire burn.
Rescuers must wear appropriate protection.
Maintain a safe distance when extinguishing flames.
Mostly lighter than water.
Most vapors are heavier than air, leading to ground-level spreading
and accumulation in low ground or enclosed spaces.
May be transported when hot.
May be transported when melted.
Dig a trough to contain the spread of extinguished fluid.
Remove container if conditions are not hazardous.
For tank fires, extinguish at maximum distance or with unmanned
extinguishing devices.
For tank fires, cool the container with excess water even after fire is
extinguished.
During tank fires, if a high pitched sound emits from the pressure
release valve or the tank becomes discolored, retreat immediately.
During tank fires, retreat from a tank consumed in flames.
During tank fires, if the fire is large-scale, use an unmanned
extinguishing device or retreat and let the fire burn.
Do not inhale dust· fumes· gas· mist· steam· spray.
Remove all potential ignition sources.
Immediately wipe spills and follow prevention measures.
Stop release if conditions are not hazardous.
Do not handle release or broken container without proper protection.
Use a plastic sheet to prevent spread.
Be aware of conditions and chemicals to avoid.
Do not enter contaminated area unless required or equipped with
appropriate protective equipment.
Remove all potential ignition sources.
Ground all instruments when handling material.
Quarantine the contaminated area.
You may use vapor suppression foam to minimize vapor formation.
Prevent introduction into waterways, sewers, basements and sealed
spaces.
Construct a bank to extinguish fire and collect water.
Absorb spills with inert materials (e.g. dry sand or earth), and dispose
of as chemical waste.
Absorb liquids and clean contaminated area with detergent and water.
Upon major leak, dig a trough away from source.
Remove absorbed material using clean explosion-proof equipment.
For prevent of Material damage, please absorb the leak.
7. Handling and Storage
A. Handling Precautions
B. Storage Precautions
Do not handle until all safety measures and precautions are read and
understood.
Use explosion-prevention electricity· ventilation· lighting· (...)·
equipment.
Use static-free tools.
Take static prevention measures.
Avoid inhalation of dust·fumes·gas·mist·steam·(...)·sprays.
Wash hands thoroughly after handling.
Do not eat, drink or smoke while using this product.
Handle outside or in locations with adequate ventilation.
Do not apply pressure, cut, fuse, solder, puncture, work or expose to
fire, sparks, static electricity or other ignition sources.
Residual material may exist after container is emptied. Follow all
MSDS/label precautions.
Handle/store with caution.
Open lid carefully.
Prolonged or continuous skin contact, please stop.
Ground all instruments when handling the material.
Be aware of conditions and chemicals to avoid.
Caution around heat.
Do not enter storage areas lacking adequate ventilation.
Keep away from heat/sparks/open flames/hot surfaces. No smoking.
Please keep the original container only.
Tightly seal container and store in well ventilated area.
Store in a cool, well ventilated area.
Because the metal corrosive substances (defined in a manufacturer
or government office) Store in a corrosion-resistant containers.
Completely drain empty drums and adequately seal. Immediately
return drum to controller or place appropriately.
Keep away from food and drinks.
8. Exposure Prevention and Personal Protection
A. Chemical Exposure Standards, Biological Exposure Standards Etc.
Domestic Regulation
Sodium Chloride
No Information
Tris (hydroxymethyl) aminomethane
No Information
Imidazole
No Information
Ethyl alcohol
TWA - 1000ppm 1900mg/m3
ACGIH Regulation
Sodium Chloride
No Information
Tris (hydroxymethyl) aminomethane
No Information
Imidazole
Not Applicable
Ethyl alcohol
TWA 1000ppm
Biological Exposure Standards
Sodium Chloride
No Information
Tris (hydroxymethyl) aminomethane
No Information
Imidazole
Not Applicable
Ethyl alcohol
No Information
B. Proper Physical Management
Use process separation, local ventilation, minimizing air
contamination below exposure thresholds etc. for physical
management.
When dust, fumes or mist is generated during use, sufficiently
ventilate to maintain air contamination below exposure thresholds.
Install face and emergency showers where this material is stored or
used.
C. Personal Protection
Respiratory Protection
Sodium Chloride
Use KOSHA certified respiratory protection appropriate for the
particular material and its physical and chemical properties.
Tris (hydroxymethyl) aminomethane
Use KOSHA certified respiratory protection appropriate for the
particular material and its physical and chemical properties.
Imidazole
Use KOSHA certified respiratory protection appropriate for the
Ethyl alcohol
9. Physical and Chemical Properties
A. Appearance
Form
Color
B. Odor
C. Threshold Odor
D. pH
E. Freezing/Melting Point
F. Boiling Point and Range
G. Flash Point
H. Evaporation Speed
I. Flammability (Solid, Gas)
J. Ignition or Explosion Range (Upper/Lower)
K. Vapor Pressure
L. Solubility
M. Vapor Density
N. Specific Weight
O. n-Octanol/Water Solubility Coefficient
P. Self-Flammability
Q. decomposition Temperature
R. Viscosity
S. Molecular Weight
Sodium Chloride
A. Appearance
Form
Color
B. Odor
C. Threshold Odor
D. pH
E. Freezing/Melting Point
F. Boiling Point and Range
G. Flash Point
H. Evaporation Speed
I. Flammability (Solid, Gas)
J. Ignition or Explosion Range (Upper/Lower)
K. Vapor Pressure
L. Solubility
M. Vapor Density
N. Specific Weight
O. n-Octanol/Water Solubility Coefficient
P. Self-Flammability
Q. decomposition Temperature
R. Viscosity
S. Molecular Weight
Tris (hydroxymethyl) aminomethane
A. Appearance
Form
particular material and its physical and chemical properties.
Use KOSHA certified respiratory protection appropriate for the
particular material and its physical and chemical properties.
If the exposure threshold is below 10000ppm, use a half-face gas
mask with an appropriate (purification) filter with a protection.
If the exposure threshold is below 25000ppm, use a loose-fitting
hood/helmet-type electric breathing aid or continuous flow helmettype gas mask with a protection.
If the exposure threshold is below 50000ppm, use a full-face or
electric half-face or Air-fed Continuous-flow type/pressure-demand
type half-face gas mask with an appropriate filter with a protection.
If the exposure threshold is below 1000000ppm, use a full-face or
hood/helmet-type, pressure-demand type air-line mask with an
appropriate filter with a protection.
If the exposure threshold is below 10000000ppm, use a SCBA or
pressure-demand type SCBA gas mask with an appropriate filter with
a protection.
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
No
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Information
Solid
Colorless, white
None
No Information
pH 6.7 (6.7-7.3)
801 ℃
1413 ℃
No Information
No Information
No Information
-/9.01575 ㎜Hg (at 1026.85℃)
360000 ㎎/ℓ
No Information
2.16
-0.46
No Information
No Information
No Information
58.44
Solid
Color
B. Odor
C. Threshold Odor
D. pH
E. Freezing/Melting Point
F. Boiling Point and Range
G. Flash Point
H. Evaporation Speed
I. Flammability (Solid, Gas)
J. Ignition or Explosion Range (Upper/Lower)
K. Vapor Pressure
L. Solubility
M. Vapor Density
N. Specific Weight
O. n-Octanol/Water Solubility Coefficient
P. Self-Flammability
Q. decomposition Temperature
R. Viscosity
S. Molecular Weight
Imidazole
A. Appearance
Form
Color
B. Odor
C. Threshold Odor
D. pH
E. Freezing/Melting Point
F. Boiling Point and Range
G. Flash Point
H. Evaporation Speed
I. Flammability (Solid, Gas)
J. Ignition or Explosion Range (Upper/Lower)
K. Vapor Pressure
L. Solubility
M. Vapor Density
N. Specific Weight
O. n-Octanol/Water Solubility Coefficient
P. Self-Flammability
Q. decomposition Temperature
R. Viscosity
S. Molecular Weight
Ethyl alcohol
A. Appearance
Form
Color
B. Odor
C. Threshold Odor
D. pH
E. Freezing/Melting Point
F. Boiling Point and Range
G. Flash Point
H. Evaporation Speed
I. Flammability (Solid, Gas)
J. Ignition or Explosion Range (Upper/Lower)
K. Vapor Pressure
L. Solubility
M. Vapor Density
N. Specific Weight
O. n-Octanol/Water Solubility Coefficient
P. Self-Flammability
Q. decomposition Temperature
R. Viscosity
S. Molecular Weight
10. Stability and Reactivity
White
Somewhat unique odor
No Information
pH 10.4
171 ~ 172℃
219 ~ 220℃ (at 10mmHg)
170 ℃
No Information
No Information
-/0.000002 ㎜Hg (at 25℃)
550 ㎎/ℓ
No Information
1.328
-1.56 (estimated)
No Information
No Information
No Information
121.14
Solid, Crystal
Colorless to yellow
Fishy smell
(No Information)
9.8 ((10.0% solution))
90 ℃ (Melting Point)
257 ℃
145 ℃
(Not Applicable)
(No Information)
- / - % (No Information)
0.0462 ㎜Hg (at 25℃ (estimated))
(Water solubility: 159 g/L at 25℃ (estimated))
2.36 (air=1)
0.6 ((water=1))
-0.08
480 ℃
(No Information)
(No Information)
68.08
Liquid
colorless
Wine or whiskey odor
10ppm
No Information
-114.1 ℃
78.5 ℃
13 ℃ (c.c.)
No Information
No Information
19 / 3.3 %
59.3 ㎜Hg (25℃)
100 g/100㎖ (25℃)
1.59 (air=1)
0.8 (water=1)
-0.31
363 ℃
No Information
1.17 cP (20℃)
46.07
A. Chemical Stability and Toxic Reaction Potential
Sodium Chloride
Toxic gases may form by decomposition under high heat.
Container may explode upon heating.
Portions may burn but will not ignite easily.
Non-volatile. The chemical itself does not burn but heating may
disintegrate and form corrosive/toxic fumes.
Tris (hydroxymethyl) aminomethane
Container may explode upon heating.
Portions may burn but will not ignite easily.
Non-volatile. The chemical itself does not burn but heating may
disintegrate and form corrosive/toxic fumes.
During a fire can cause irritation, corrosive, toxic gas.
Imidazole
May cause corrosion metals.
Toxic gases may form by decomposition under high heat.
Container may explode upon heating.
Contact with some metals and can generate flammable hydrogen gas.
Non-volatile. The chemical itself does not burn but heating may
disintegrate and form corrosive/toxic fumes.
Some oxidizers may ignite combustibles as.
Ethyl alcohol
Highly flammable liquid and vapor
May violently polymerize and cause fire and explosions.
May form explosive mixture near and above ignition point.
Container may explode upon heating.
Highly flammable: Easily ignited with heat, sparks or flames.
Leaks may lead to fire/explosions
Vapor explosion hazard indoors, outdoors and in sewers.
May form explosive mixture when vapor is mixed with air.
The vapor moves to the ignition source may be a flash back.
Without an awareness of vapor may cause dizziness or suffocation.
B. Conditions to Avoid
Sodium Chloride
Keep away from heat/sparks/open flames/hot surfaces. No smoking.
Tris (hydroxymethyl) aminomethane
Keep away from heat/sparks/open flames/hot surfaces. No smoking.
Imidazole
Heat
Ethyl alcohol
Keep away from heat/sparks/open flames/hot surfaces. No smoking.
C. Chemicals to Avoid
Sodium Chloride
Flammable material, reducing material.
Tris (hydroxymethyl) aminomethane
Flammable material, reducing material.
Imidazole
Flammable material, reducing material.
Metal
Ethyl alcohol
No Information
D. Toxic Chemicals Formed with Decomposition
Sodium Chloride
Irritating and highly toxic gases may form while burning through heat
decomposition or combustion.
Tris (hydroxymethyl) aminomethane
Irritating and highly toxic gases may form while burning through heat
decomposition or combustion.
Imidazole
Irritating and highly toxic gases may form while burning through heat
decomposition or combustion.
Ethyl alcohol
Irritating and highly toxic gases may form while burning through heat
decomposition or combustion.
11. Toxicology Information
A. Probable Exposure Paths
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
No Information
No Information
May cause irritation, respiratory distress, headache, dizziness,
sleepiness, loss of motor function.
May cause burns.
May cause irritation.
May cause irritation, respiratory distress, headache, dizziness,
sleepiness, loss of motor function.
May cause hypothermia or heating, change in blood pressure,
vomiting, respiratory distress, irregular heartbeats, sleepiness, loss of
direaction, vocalimpairment, emotional change, loss of motor
function, visual impairment, pupil dialation, seizures, loss of
conciousness.
May cause irritation.
IARC is habit of drinking alcohol when classified as a potential
carcinogen in humans, ACGIH is mainly to harmful factors in the work
environment ethanol A4 (not classified as human carcinogens),
classified as:
B. Heath Hazard Information
Acute Toxicity
Oral
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Skin
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Inhalation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Skin Corrosion or Irritation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Severe Eye Damage or Irritation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Respiratory Hypersensitivity
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Skin Hypersensitivity
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Carcinogenic Properties
Industrial Safety Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Department of Labor Notice
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
IARC
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
OSHA
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
LD50
LD50
LD50
LD50
3000 ㎎/㎏ Rat
5900 ㎎/㎏ Rabbit
960 ~ 970 ㎎/㎏ Rat
6200 ㎎/㎏ Rat
LD50 > 10000 ㎎/㎏ Rabbit
No Information
(No Information)
No Information
Dust LC50> 10.5 ㎎/ℓ 4 hr Rat
No Information
(No Information)
LC50 20000 ppm 10 hr Rat
Rabbit: Minimal irritant.
Causes skin irritation.
4 hours after exposure, 24 hours in 48 hours, necrosis takes place.
No irritation.
Rabbit: Medium irritation.
Causes eyes irritation.
10-12 day Recovery irritation, 1day in 8day, Cause a slight
inflammation, The iris score 5/10, chemosis score 10~14
Irritating to medium.
Human corneal damage, Conjunctival injection on days 1 and 2
recovered. (ACGIH (2001))
No
No
No
No
Information
Information
Information
Information
No
No
No
No
Information
Information
Information
Information
No
No
No
No
Information
Information
Information
Information
No Information
No Information
No Information
1A (Drinking alcohol only)
No Information
No Information
No Information
Group 1 (Excessive drinking of alcohol (in alcoholic beverages))
No
No
No
No
Information
Information
Information
Information
ACGIH
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
NTP
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EU CLP
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Reproductive Cell Mutation Properties
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Reproductive Toxicity
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Target Organ Toxicity (Single Exposure)
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Target Organ Toxicity (Repeat Exposure)
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
No Information
No Information
No Information
A3
No
No
No
No
Information
Information
Information
Information
No
No
No
No
Information
Information
Information
Information
In vitro - Salmonella typhimurium/TA97, TA98, TA100, TA1535,
TA1537, TA1538(Ames test): Negative, Nonhuman/Chromosome
abberation test:Negative, CHO Cells/Chromosome abberation test:
Positive
No Information
Ames test: Negative
Salmonella typhimurium TA1535, TA97, 98, 100, 102 : 0.625, 1.25,
2.5, 5, 10 mg/plate, Unscheduled DNA synthesis : Negative
Rat primary hepatocytes: 0.25, 0.5, 1, 2, 4 mg/ml, In vivo: Negative
NMRI mouse : 500, 1000, 2000 mg/kg bw
White rat and mouse dominant lethal dose testing – Positive
Reports of aneuploidy in mouse reproductive cells.
Female/placental administration (27 mg/kg for 15W of pregnancy):
Miscarriage, fetal toxicity, musculoskeletal abnormality
No Information
Reproductive Toxicity: Negative
Developmental and teratogenicity toxicity: NOAEL materal/
developmental toxicity/teratogenicity : 60 mg/kg bw
Rat(Wistar), Dose : 0, 20, 60, 180 mg/kg bw/d(14 d) test result:
Highest concentrations in patients of 6-8day and 17-20 day
gestation period was significantly reduced body weight, The influence
of body weight, especially 17-20 days 26% reduction in uterine
weight caused, reabsorption ratio increased, the average fetal weight
and mother-compared to the low toxicity. Reduction in the ratio,
Increased post-implantation loss. Mother-toxic effects were, 10%
increase in skeletal abnormalities
Several reports of habitual large-quantity consumption of alcohol in
humanshaving ill effects on fetuses including deformation.
Rat/Oral (1 mg/kg/24hr): Sodium-Potassium excretion effect.
Irritating to pray inhalation.
Unbalance of convulsions and lateral posture.
Affects human central nervous system and causes headache, fatigue,
loss of focus.
Inhalation may cause tracheal irritation, lightheadedness and
pathologic somnolence.
High blood pressure rats injected with salt displayed kidney and
arterydisability, nephron and glomerular damage. No effect on nonsalt injectednormal rats. Potassium intake prevents high blood
pressure. Rat/Oral (16800 mg/kg/28D): TOXIC EFFECTS: Endocrinal Adrenal gland weight difference
Rat/Oral (16800 mg/kg/28D): TOXIC EFFECTS: Endocrine – Changes
in adrenal weight
No Information
Target organ: Liver and kidney Rat NOAEL: about 60 mg/kg, 90일
Exposure, Concentration 0, 20, 60, 180 mg/kg bw/d, Renal proximal
convoluted tubule α2u-microglobulin store.
Ethyl alcohol
Inhalation Toxicity
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
12. Ecological Information
A. Biological Toxicity
Fish
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Crustacean
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Avian
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
B. Persistency and Degradability
Persistency
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Degradability
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
C. Bioconcentration
Concentration
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Biodegradability
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
D. Soil Mobility
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
E. Other Toxic Effects
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
13. Disposal Information
A. Disposal Method
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Affects human liver, nervous system (seizures, hallucinations etc.).
No
No
No
No
Information
Information
Information
Information
LC50
LC50
LC50
LC50
1294.6 ㎎/ℓ 96 hr Lepomis macrochirus
955.892 ㎎/ℓ 96 hr
327 ㎎/ℓ 96 hr 기타
42 ㎎/ℓ 96 hr Oncorhynchus mykiss
EC50
EC50
EC50
EC50
402.6 ㎎/ℓ 48 hr Daphnia magna
19.793 ㎎/ℓ 48 hr
341 ㎎/ℓ 48 hr Daphnia magna
2 ㎎/ℓ 48 hr Daphnia magna
No Information
EC50 163.053 ㎎/ℓ 96 hr
ErC50 133 ㎎/ℓ 72 hr Scenedesmus subspicatus
No Information
log Kow -0.46
log Kow -1.56 (estimated)
log Kow -0.08
No Information
No Information
No Information
No Information
BOD5/COD 0.57
BCF 3.162
BCF 3
No Information
No Information
No Information
No Information
98 (%) 18 day
75 (%) 20 day (Aerobic, other, easily degraded)
No
No
No
No
Information
Information
Information
Information
No
No
No
No
Information
Information
Information
Information
Observe all local and national environmental regulations if applicable.
Observe all local and national environmental regulations if applicable.
Observe all local and national environmental regulations if applicable.
Ethyl alcohol
B. Disposal Considerations
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
14. Transport Information
A. UN No.
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
B. Proper Shipping Name
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
1) If possible, pre-separate oil and water.
Observe
Observe
Observe
Observe
all
all
all
all
local
local
local
local
and
and
and
and
national
national
national
national
regulations
regulations
regulations
regulations
if
if
if
if
applicable.
applicable.
applicable.
applicable.
No classification information.
No classification information.
1759
1170
Not Applicable
Not Applicable
CORROSIVE SOLID, N.O.S.
ETHANOL(ETHYL ALCOHOL) or ETHANOL SOLUTION(ETHYL
ALCOHOL SOLUTION))
C. Shipping Hazard Classification
Sodium Chloride
Not Applicable
Tris (hydroxymethyl) aminomethane
Not Applicable
Imidazole
8
Ethyl alcohol
3
D. Container Classification
Sodium Chloride
Not Applicable
Tris (hydroxymethyl) aminomethane
Not Applicable
Imidazole
1
Ethyl alcohol
2
E. Marine Pollutant
Sodium Chloride
No Information
Tris (hydroxymethyl) aminomethane
No Information
Imidazole
No Information
Ethyl alcohol
No Information
F. Special Safety Measures for Users Regarding Shipping or Shipping Measures
Fire Emergency Measures
Sodium Chloride
Not Applicable
Tris (hydroxymethyl) aminomethane
Not Applicable
Imidazole
F-A
Ethyl alcohol
F-E
Release Emergency Measures
Sodium Chloride
Not Applicable
Tris (hydroxymethyl) aminomethane
Not Applicable
Imidazole
S-B
Ethyl alcohol
S-D
15. Regulatory Status
A. Industrial Safety and Health Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
B. Hazardous Chemical Management Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
C. Dangerous Material Management Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
D. Waste Management Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
environmental
environmental
environmental
environmental
No Information
No Information
No Information
Exposure limited chemical
No
No
No
No
Information
Information
Information
Information
No Information
No Information
No Information
Type 4 Alcohols 400ℓ
No Information
No Information
Imidazole
Ethyl alcohol
E. Other Domestic and International Regulations
Domestic Regulation
Residual Organic Contaminant Management
Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
International Regulations
OSHA Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
CERCLA Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EPCRA 302 Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EPCRA 304 Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EPCRA 313 Regulation
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Rotterdam Convention Substance
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Stockholm Convention Substance
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
Montreal Protocol Substance
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EU Classification (Confirmed Classification
Result)
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EU Classification (Risk Phrases)
Sodium Chloride
Tris (hydroxymethyl) aminomethane
Imidazole
Ethyl alcohol
EU Classification (Safety Phrases)
Sodium Chloride
Tris (hydroxymethyl) aminomethane
No Information
Designated waste
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not
Not
Not
Not
Applicable
Applicable
Applicable
Applicable
Not Applicable
Not Applicable
Not Applicable
F; R11
Not Applicable
Not Applicable
Not Applicable
R11
Not Applicable
Not Applicable
Not Applicable
Imidazole
Ethyl alcohol
S2, S7, S16
16. Other References
A. Source of Information
Sodium Chloride
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (Form)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (Color)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (B. Odor)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (D. pH)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (E. Freezing/Melting Point)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (F. Boiling Point and Range)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (K. Vapor Pressure)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (L. Solubility)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (N. Specific Weight)
Quantitative Structure Activity Relation(QSAR) (O. n-Octanol/Water Solubility Coefficient)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (S. Molecular Weight)
International Uniform ChemicaL Information Database(IUCLID)(http://ecb.jrc.it/esis) (Oral)
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com) (Skin)
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com) (Inhalation)
International Uniform ChemicaL Information Database(IUCLID)(http://ecb.jrc.it/esis) (Skin Corrosion or Irritation)
International Uniform ChemicaL Information Database(IUCLID)(http://ecb.jrc.it/esis)
(Severe Eye Damage or Irritation)
National Library of Medicine/genetic toxicology(NLM/GENETOX)(http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?GENETOX) (Reproductive Cell Mutation Properties)
International Uniform ChemicaL Information Database(IUCLID)(http://ecb.jrc.it/esis)
(Reproductive Cell Mutation Properties)
National Library of Medicine/Chemical Carcinogenesis Research Information
System(NLM/CCRIS)(http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS)
(Reproductive Cell Mutation Properties)
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com) (Reproductive Toxicity)
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com)
(Target Organ Toxicity (Single Exposure))
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com)
(Target Organ Toxicity (Repeat Exposure))
International Uniform ChemicaL Information Database(IUCLID)(http://ecb.jrc.it/esis)
(Target Organ Toxicity (Repeat Exposure))
The ECOTOXicology database (ECOTOX)(http://cfpub.epa.gov/ECOTOX/quick_query.htm) (Fish)
The ECOTOXicology database (ECOTOX)(http://cfpub.epa.gov/ECOTOX/quick_query.htm) (Crustacean)
Quantitative Structure Activity Relation(QSAR) (Persistency)
Quantitative Structure Activity Relation(QSAR) (Concentration)
Tris (hydroxymethyl) aminomethane
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (Form)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (Color)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (B. Odor)
The Merck Index 13th Ed.(D. pH)
National Library of Medicine/Hazardous Substances Data Bank(NLM/HSDB)(http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB) (E. Freezing/Melting Point)
National Library of Medicine/Hazardous Substances Data Bank(NLM/HSDB)(http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB) (F. Boiling Point and Range)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (G. Flash Point)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (K. Vapor Pressure)
National Library of Medicine/Hazardous Substances Data Bank(NLM/HSDB)(http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB) (L. Solubility)
The Chemical Database, The Department of Chemistry at the University of
Akron(http://ull.chemistry.uakron.edu/erd) (N. Specific Weight)
HSDB(O. n-Octanol/Water Solubility Coefficient)
National Library of Medicine/Hazardous Substances Data Bank(NLM/HSDB)(http://toxnet.nlm.nih.gov/cgibin/sis/htmlgen?HSDB) (S. Molecular Weight)
Corporate Solution From Thomson Micromedex(http://csi.micromedex.com) (Oral)
Ecological Structure Activity Relationships(ECOSAR) (Fish)
Ecological Structure Activity Relationships(ECOSAR) (Crustacean)
Ecological Structure Activity Relationships(ECOSAR) (Avian)
HSDB (Persistency)
HSDB (Concentration)
Akron University(http://ull.chemistry.uakron.edu/erd/)
Imidazole
TOME(Oral)
SIDS(Skin Corrosion or Irritation)
SIDS(Severe Eye Damage or Irritation)
SIDS(Reproductive Cell Mutation Properties)
SIDS(Reproductive Toxicity)
SIDS(Target Organ Toxicity (Single Exposure))
SIDS(Target Organ Toxicity (Repeat Exposure))
SIDS(Fish)
SIDS(Crustacean)
SIDS(Avian)
SIDS(Biodegradability)
Ethyl alcohol
HSDB(Form)
HSDB(Color)
HSDB(B. Odor)
HSDB(C. Threshold Odor)
HSDB(E. Freezing/Melting Point)
HSDB(F. Boiling Point and Range)
HSDB(G. Flash Point)
ICSC(J. Ignition or Explosion Range (Upper/Lower))
HSDB(K. Vapor Pressure)
HSDB(L. Solubility)
HSDB(M. Vapor Density)
ICSC(N. Specific Weight)
HSDB(O. n-Octanol/Water Solubility Coefficient)
HSDB(P. Self-Flammability)
HSDB(Viscosity)
HSDB(S. Molecular Weight)
ECOTOX(Fish)
ECOTOX(Crustacean)
IUCLID(Degradability)
IUCLID(Biodegradability)
HSDB(D. Soil Mobility)
ECB-ESIS(European chemical Substances Information System)(http://ecb.jrc.it/esis)
ECOTOX Database, EPA(http://cfpub.epa.gov/ecotox)
HSDB, U.S. National Library of Medicine(http://toxnet.nlm.nih.gov)
IUCLID Chemical Data Sheet, EC-ECB
International Chemical Safety Cards(ICSC)
Korea dangerous material inventory management system, National Emergency Management Agency
(http://www.nema.go.kr/hazmat)
B. Initial Issue Date
2011-06-30
C. Revision Count and Latest Revision Date
Revision Count
0
Latest Revision Date
0
D. Other
○ This Material Safety Data Sheet (MSDS) is based on, edited and partially modified from a MSDS
obtainedfrom the Korean Occupational Safety & Health Agency.