Unique Aberration-Free
IOL: A Vision that
Patients Can Appreciate
Akreos AO: An Aspheric Optic
for Improved Quality of Vision

Traditional spherical IOLs create spherical
aberration and reduce contrast sensitivity

With Akreos AO, unique aspheric anterior and
posterior surfaces are aberration neutral

The result? Clinical outcomes demonstrate a
reduction in overall higher order aberrations 1

Contrast sensitivity under photopic or mesopic
lighting conditions similar to silicone aspheric
aberrated IOL.2
Bilateral implantation study
High Order Aberrations at 3 months: 6mm pupil
2
G. Lofoco. Influence of Aspheric and Spherical IOLs on Higher-Order
Aberrations and Functional Vision: Results of a Comparative Multicenter Study. ASCRS 2006.
1
Bilateral implantation study
Photopic Contrast Sensitivity: 85 cd/m2
Mesopic Contrast Sensitivity: 3 cd/m2
B. Johansson et al. Swedish multi-center study to compare the optical performance of the Akreos Adapt Advanced Optic (AO) IOL and
the Tecnis Z9000. ASCRS 2006.
2
Akreos AO: Uniform Power
Designed to Work in Every Eye

No eye is optically perfect

Constant power from centre to edge helps to
improve vision by providing consistent power
across the entire optic surface

Clinical results show excellent high and low
contrast BCVA comparable to a middle-age
phakic eye 3

Akreos AO is designed to provide predictable,
repeatable refractive outcomes for all cataract
patients, regardless of corneal shape, pupil size,
as well as pupil or capsular bag centration.
The Natural Phakic Eye
OPTICAL AXIS
(Cornea to Lens)
VISUAL AXIS
(Object to Fovea)
IRIS
FOVEA
LENS
RETINA
3
All axes in the eye are not perfectly aligned and no two eyes are the same
shape so you need IOLs that work with imperfect conditions.
BCVA compared to phakic eyes
3
V. Pfeifer. Clinical evaluation of a new aspheric IOL: the Akreos Adapt Advanced Optics (AO). Data from a pilot study at six months
follow up. ASCRS 2006.
Akreos AO: Aberration-Free Design
Helps to Enhance Depth of Field

The phakic eye has some natural level of positive
spherical aberration

Positive spherical aberration helps the phakic eye
achieve better depth of field

Akreos AO maintains the natural, positive spherical
aberrations compared to aspheric, aberrated
IOLs 2 (top figure)
Natural Functionality
4

With its aberration-free design, Akreos AO helps to
significantly improve depth of field in comparison
to an aspheric aberrated IOL. 2 (bottom figure)
Bilateral implantation study
Depth of focus in intermediate vision
Corneal Peripheral rays
Corneal Medium rays
Corneal Central rays
In intermediate vision more distant objects are seen through
central corneal rays whereas closer objects are seen through
peripheral corneal rays.
4
Mean Depth of Field 4
p=0,03
Number of patients
Akreos AO
Silicone Aspheric
Aberrated IOL
0.85 Dpt
0.71 Dpt
74
74
2
B. Johansson et al. Swedish multi-centre study to compare the
optical performance of the Akreos Adapt Advanced Optic (AO) IOL
and the Tecnis Z9000. ASCRS 2006.
Measured with the Strehl ratio as described by S. Marcos et al. Implantation of Spherical and Aspheric IOLs. Journal of Refractive Surgery. May-June 2005; 21:1-13.
Akreos AO: A Visual Difference
Patients Appreciate

A masked, subjective patient assessment following
cataract surgery showed that twice as many patients
prefer the vision in their Akreos AO eye 2 (left figure)

Patients also reported fewer visual disturbances
in their Akreos AO eye compared to the silicone
aspheric aberrated IOL eye 2 (right figure)

Patients had no way to know which lens was
implanted in their eyes.
Bilateral implantation study: double-masked questionnaire
Any preference for one eye
Less dysphotopsia in one eye
No difference 58%
(n=80)
No difference 56%
(n=55)
B. Johansson et al. Swedish multi-centre study to compare the optical performance of the Akreos Adapt Advanced Optic (AO) IOL and
the Tecnis Z9000. ASCRS 2006.
2
5
Akreos AO: For Optimised
Effectiveness against PCO

The unique Square-Edge Technology and a 360°
posterior barrier reduce cell migration following
implantation

EPCO analysis shows just how effective the
Akreos AO design is in blocking cell growth 3

Results are comparable to the best performing
acrylic IOLs.5
Akreos Advanced Optics
6
@ 3 months
@ 6 months
@ 12 months
6mm optic area
0.048
0.048
0.048
3mm central area
0.007
0.008
0.012
(n=42)
(n=48)
(n=41)
EPCO Scores
EPCO Scores @ 12 months
Limit at which PCO does not require Nd:Yag capsulotomy*
Akreos AO 3
One-Piece Hydrophobic Acrylic Lens 5
* Nd:Yag capsulotomy usually performed beyond 0.5 to 1.0, depending on PCO location and patient’s complaint.
3
5
V. Pfeifer. Clinical evaluation of a new aspheric IOL: the Akreos Adapt Advanced Optics (AO). Data from a pilot study at six months follow up. ASCRS 2006.
Data on file.
Akreos AO: Efficient Implantation through
an Unenlarged Phaco Incision

The Akreos Single-Use Insertion Device enables
implantation of the Akreos AO through a 2.8mm
phaco incision

The flat loading, single-hand injection makes
quick work of lens implantation

Improved plunger design provides symmetrical
unfolding and easier placement of the lead
haptic into the capsular bag.
Single-Use Lens Delivery System
7
Akreos™ Single-Use Insertion Device AI-28
1. Place the lens flat in to the loading deck
2. Close the injector and fit the tip
3. Advance the plunger and deliver the lens
SofPort Advanced Optics System
Model: Adapt AO
Model: LI61AO
MATERIAL: 26% acrylic material,
UV absorber, Refractive index: 1.458
(hydrated)
DIOPTRE RANGE:
0.0 through 9.0 in 1.0 Dpt
10.0 through 30.0 in 0.5 Dpt
MATERIAL: Optic: Silicone, class 1,
UV absorber, Refractive index: 1.427
Haptics: blue extruded PMMA
DIOPTRE RANGE:
0.0 through 4.0 in 1.0 Dpt,
5.0 through 30.0 in 0.5 Dpt
OPTIC: Biconvex aspheric anterior
and posterior, Optic body: 6mm
A-CONSTANT:
US Biometry*: 118.0
Zeiss IOL Master*: 118.6
OPTIC: Biconvex aspheric anterior
and posterior, Optic body: 6mm
A-CONSTANT*: 118.0
HAPTICS: Modified-C, 5º loop angle
SURGEON FACTOR*: 1.22
OVERALL DIAMETER: 13mm
ORDER CODE:
Lens: LI61AOR, Injector: EZ-28
HAPTICS: One-piece, 0º angulation
OVERALL DIAMETER:
11.0mm from 0.0 to 15.0 Dpt
10.7mm from 15.5 to 22.0 Dpt
10.5mm from 22.5 to 30.0 Dpt
ACD*: 4.96mm
SURGEON FACTOR*: 1.22
ORDER CODE:
Lens: Akreos AO, Injector: AI-28
ACD*: 5.0mm
* A-Constant, ACD and Surgeon Factor are estimates only. It is recommended that each surgeon develop his or her own values.
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Akreos Advanced Optics System
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Bausch & Lomb Aspheric IOLs: Available in two lens materials