Technology and Innovation, Vol. 16, pp. 259–269, 2014 Printed in the USA. All rights reserved. Copyright Ó 2014 Cognizant Comm. Corp. 1949-8241/14 $90.00 + .00 DOI: http://dx.doi.org/10.3727/194982414X14138187301777 E-ISSN 1949-825X www.cognizantcommunication.com Leadership Role of Nanotechnology Innovation in Economic Development and Governmental Policy Samuel M. Rapaka,* Anastasia Groshev,† Yashwant V. Pathak,* and Vijaykumar B. Sutariya* *College of Pharmacy, Department of Pharmaceutical Sciences, University of South Florida, Tampa, FL, USA †Morsani College of Medicine, University of South Florida, Tampa, FL, USA Nanoparticle technology is implemented in a wide variety of industrial fields, including electronic devices, solar energy systems, stain-resistant fabrics, and even in medical biotechnology dealing with targeted drug delivery. The commercialization of nanoparticle technology has a large impact on the economy in regard to growth and expansion of pharmaceutical and electronics industries, enhanced workforce training and education, and an increase in the number of jobs associated with development of nanotechnology. The Organisation for Economic Co-operation and Development estimate a global output ranging from US$1 trillion to US$3 trillion in manufactured goods incorporating nanotechnology and over 2 million new jobs. The future of the growth of nanoparticle technology relies on innovation by increasing industrial financial resources allocated to research and development and partnerships with universities. In 2013, the federal budget provided $1.8 billion investments in the National Nanotechnology Initiative, a central agency engaged in nanotechnology research and development, which added to the $18 billion of federal investments since 2001. The large increase in nanotechnology innovation can be assessed by the 150% increase in nanotechnology patent literature since 2006. Government policy regarding nanotechnology is handled by the agencies responsible for the consumer product. The food and drug administration (FDA) handles most of the healthcare applications, but there is a call for more regulation of nanotechnology in other fields in fear of any long-term effects from exposure. Together, the economic development, innovation, and government policy will dictate the future growth of nanotechnology in the US and worldwide. Key words: Nanotechnology; Nanomaterials; Economic development; Government policy INTRODUCTION uses, they have many biomedical applications in targeted drug delivery. The National Nanotechnology Initiative (NNI) defines nanotechnology as research and technology on a scale of 1- to 100-nm range at atomic, molecular, and macromolecular levels, which can substantially differ based on the material and functional application (17,23,25,28). Nanoparticles have a variety of unique assets, such as structural, thermal, quantum, and electromagnetic properties, that make Nanoparticle technology has become a valuable asset in a wide variety of industries and industrial products due to its ability to deviate from properties of the bulk material based on the particle size, making it useful in a wide variety of applications. Nanoparticle materials are used in a variety of commercialized goods from polymers used in fabrics to sporting goods, helmets, cosmetic products, and electronic products. In addition to these industrial Accepted September 15, 2014. Address correspondence to Vijaykumar B. Sutariya, Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, MDC 30, 4202 E. Fowler Avenue, Tampa, FL 33612-4749, USA. Tel: +1-813-974-1401; Fax: +1-813-974-9890; E-mail: vsutariy@health.usf.edu 259 260 Rapaka ET AL. them useful in a variety of fields and applications. The ultrafinite size of the particles allows them to be more easily absorbed into biological membranes, making them a sought-after vehicle of drug delivery by the pharmaceutical industry. At a low particle size, the thermal properties of the material can deviate from that of the bulk material, which has its own applications in altering the melting points and improving performance of materials such as ceramics (17,22). The electrical properties along with particle size make nanoparticles useful in making small and thinner electronic devices. Further, the performance of these products can be improved by having raw materials with high dielectric constants, a property that tends to increase considerably at finite particle size (17). These are some of the quantum effects on a material’s properties that allow nanoparticle technology to be implemented in a wide variety of industrial fields as well as in the medical and biotechnology industry. Founded in 2000, the NNI has been a launching pad for the rapid development of nanotechnology in the US. The 2015 Federal Budget provides $1.5 billion for NNI with cumulative investments since the inception of NNI of $21 billion (24). In return, NNI can boast of countless breakthroughs in a variety of areas such as electronics, energy, food, agriculture, health, infrastructure, and nanobiology. One of the examples of NNI-funded projects is the development of a nano-assisted, intraoperative brain tumor therapy wherein a nontoxic two-photon photodynamic nanoparticle can be used for labeling of the tumor for precise tumor debulking surgery (8,15). Nanotechnology has been experiencing rapid growth and, with the direction of NNI, it is expected to be a significant economical contributor offering solutions to current challenges in many different disciplines. Between 2000 and 2020, it is expected that a rapid advancement in foundational knowledge and application of nanomaterials will happen that can be divided into four phases (27). The first 5 years after the NNI was developed gave rise to passive nanostructures such as coatings, nanoparticles, and ceramics. The second 5 years has been a transition to active nanostructures such as amplifiers and targeted drugs (27). The next 10 years have been predicted to be the shift into nanosystems with applications in robotics and molecular devices (27). As a field developing on a canvas of interdisciplinary collaborations, it is shaped by multiple factors such as economic development, innovation, and government regulation. In return, nanotechnology impacts the economy in a complex network of interactions of international government, large companies and small startup companies, marketing, and academic research. INNOVATION Financial Resources for Economic Growth and Development of Nanotechnology Field In the US, the first surge to advance nanoscale science and engineering started in October 1998 with the establishment of the Interagency Working Group on NanoScience, Engineering and Technology (IGWN) by the National Science and Technology Council (NSTC) (10). This eventually led to the NNI, which proposed an initial 56% in federal funding with priorities of expediting longterm research, application of materials to innovate technologies, education, and also addressing societal implications (26). National Nanotechnology Initiative The federal government has taken the role of funding research and development through the NNI, as well as by assisting companies through several grants such as the Small Business Innovation Research (SBIR) grant (21). The government hopes that by offering these grants, they can fund research and development and help small businesses to bridge the gap between development and commercialization known as the “valley of death.” Another program to assist companies in bridging this gap is known as the Advanced Technology Program, which was designed to help companies invest in long-term early stage research to develop innovative technologies, a high-risk aspect of innovative approaches. The NNI investment since 2001 now totals almost $21 billion, and additional investment in research dealing with nanotechnologyrelated environmental and health research totals nearly $900 million since 2005 (21). In addition to these federal/industry partnerships, additional advancements in innovation are made at the industry/state level, which include partnerships with university LEADERSHIP ROLE OF NANOTECHNOLOGY INNOVATION research programs. Companies such as Albany Nanotech, based at the University of Albany, have various partnerships with over 100 companies (as well as the state of New York) and have yielded $1.6 billion toward research and development. These investments have helped Albany Nanotech develop facilities and tools that can help these companies in collaboration with Nanotech to overcome their own barriers to development (21). This unique collaboration between state, corporate, and universities has helped each party make advancements toward their short- and long-term development goals. Because nanotechnology is often considered a high-risk invest­ ment, its further development relies on the continued federal support for long-term development, but it is the industries’ job to capitalize on this support through commercialization. The increased number of patents related to nanotechnology, and processes involved in its development and applications, have been a positive result of this increased federal and corporate investment. From 2000 to 2008, the estimated growth rate in nanotechnology patent applications was 34.5% (21). Federal and Corporate World Collaborations The innovation of nanotechnology is driven by federal–corporate collaborations through the NNI and other various grant initiatives that provide funding for research and development of nanotechnology. The innovation is furthermore expanded in state–corporate collaborations with universities and other smaller businesses. The final goal of these collaborations is increased efficiency of investments in helping companies bridge the gap between development and commercialization. The NNI can be seen as a US response to the beginning of the global race between the world’s economies in developing nanotechnology programs (10). During this time, the worldwide investment in nanotechnology by government organizations increased about ninefold from 1997 to 2005 (27). The European Commission is the largest funding organization of nanotechnology research in Europe, investing nearly 1.3 billion euros from 2004 to 2006 (10). Other significant funding comes from Japan, Germany, France, and South Korea, respectively (10). The US still leads all expenditures with nearly 261 3 billion euros in 2004 and 2005 alone compared to the 2.3 billion euros for Japan and less than 2 billion euros for Europe (10). The gap between Europe and the US total funding is explained by the large role of the private sector in funding. In the US, the private sector accounts for 60% of total funding, whereas Japan’s private sector accounts for more then two thirds of funding (10). For all other countries, mainly the emerging Asian countries, the private sector accounts for 40% of expenditures (10). The venture capital investments share in the total investments has increased more than 2% from 1999 to 2005 (10). The venture capitalists mainly have an interest in nanobiotechnology, followed by nanomaterials and nanodevices. Specifically, the balance of public and private funding in the US creates a market where companies can meet demand in new and creative ways, create new jobs, and expand into new venues. NNI and US Universities The NNI has helped make major advancements in the nanotechnology field through federal investments, but states and regional economies are hoping to become boosted by American universities through the convergence of university and industrial research (29). This promotes additional investments by universities as they seek to be at the forefront of research and secure support and resources. Although there has been a considerable amount of growth of nanotechnology in the industry, it is still emerging in university settings. The challenges of costly facilities and assembling the wide arrangement of staff to deal with the interdisciplinary aspects in an organized manner are a few of the challenges to face academia. The University of Albany School of Nanotechnology is a unique example in which entrepreneurs stepped in to bring resources and ideas to create a complex that would eventually contribute to the regional nanoelectronics cluster (29). The university’s new School of Nanotechnology did not seek a close relationship with any corporation but instead looked toward establishing broad interorganizational partnerships where various firms with complementary goals could work together to contribute to a higher platform. This creation of the School of Nanotechnology for close work with the industry and collaboration of experts in various 262 Rapaka ET AL. fields demonstrates the trend of fusion of sciences and the field in nanotechnology that is necessary for further growth and development (12). Military and Defense Applications of Nanotechnology The commercial uses of nanotechnology show great promise to improve many industrial fields and the economy. These improvements have also been translated into defense applications that can possibly change the future of weaponry and warfare. The main goal of military nanotechnology research is for the improvement of medical care and enhanced protective equipment (2). Through the use of nanomaterials, the defense industry aims to produce lightweight, durable, and functional body armor. The Institute for Soldier Nanotechnologies (ISN) is developing jumpsuit-style outfits that incorporate these nanomaterials, which surpass the strength of current materials, as well as the integrated ability to protect against biological and chemical warfare (16). These nanostructures, specifically engineered with large surface areas containing highly reactive functional groups, can improve the sensitivity and reaction time of current biological and chemical sensors (1,16). These suits are being developed to include health monitoring systems, adaptive camouflage, self-repairing material, as well as stealth coatings (2,30). One of the first steps toward the health-monitoring systems are screen-printing sensors (University of California) placed on the waistband of underwear, which can monitor biomarkers in the sweat of the person (32). Biosensors are also being utilized beyond body armor, enhancing current defense technologies including the development of highly sensitive thermal sensors, high-performance camera systems, and improved GPS systems for position sensing (2). The range of applications that are currently in research and development includes improved vehicles, robotics, and whole new classes of weapons that can transform the future of warfare. New classes of weapons currently under development include highprecision lasers, like those depicted in the fictional “Star Trek” series, that can be set to stun or kill enemies (19). This precise laser is one example of the new age of nanotechnology-inspired smart weapons that aim to decrease the amount of civilian casualties. Nanotechnology has the potential to completely change the defense landscape from the military equipment to weaponry to the way we regulate warfare. Measurement of Development in the Field of Nanotechnology The measurement of the development of nanotechnology can be clarified with the help of the Techno-Economic Network (TEN), which provides a framework to analyze the innovation of nanotechnology (12). The concept is organized around three components—science, technology, and market— with all playing a direct role in the developmental process (see Fig. 1). Each component has its own supporting agencies involved and its own measure of development. The scientific component can be assessed through publications, the technology component can be measured with patents, and the market component can be assessed through market studies (12). Therefore, we can survey the measurement of development of nanotechnology by assessing each of the components individually. From the scientific aspect of nanotechnology innovation, the agencies involved are industrial and academic labs and can be evaluated through publications. The number of publications is an appropriate indicator of scientific output in the field, but it should also be noted that the quality or impact of a paper, measured by how often it is cited, should be taken into account when assessing the influence of publications on the field of nanotechnology (10). The overall growth of nanotechnology publications is continuous, but more remarkable is the increase in publications from China and India (4). In 2000, the US led the publication contribution accounting for 27% of papers, followed by Japan (14.5%) and China (9.8%). In 2009, China led the way, accounting for 23%, followed by the US (21%) and Japan (9.8%). With the number of publications on an exponential rise in Asian countries, the number of the top 1% of cited works is still led by the US with 257 papers, followed most closely by China (with 132) and Germany (with 103) (25). As the amount of publications has risen globally, the number of countries rising to competency in the scientific research initiative has also increased. The technology aspect of nanotechnology innovation can be assessed through patents. Patents reflect the ability to transfer scientific results into technological applications and are a preliminary phase between LEADERSHIP ROLE OF NANOTECHNOLOGY INNOVATION 263 Figure 1. Nanotechnology development. Three areas of development include science, technology, and the market. Each area can be assessed based on its respective factors. The development of science can be measured via number of publications, citations, and the number/type of topics. Technology development can be measured in number of patents, and the success of the market is usually measured via market studies, business relations, and revenue. research and economic exploitation. According to the European Patent Office (EPO) worldwide patent database, there is a trend of an increasing number of nanotechnology patents (see Fig. 2). According to the EPO data on nanotech patents, the number of patent families has increased continuously through 2006 but with no real takeoff (10). Although the growth of the number of patents is not dramatic, there is a steady increase of patents since 2005, most likely due to increased collaborations between research institutions and the industry worldwide (see Fig. 2). However, growth is not even throughout the branches of nano­ technology—the largest group of patents belonged to nanoelectronics (29%), followed closely by nanomaterials (25%). From 2000 to 2008, the number of patented nanotechnologies increased 34.5% (6). In this time period, the US led the global market in patents, followed by China, Japan, Germany, South Korea, and France (6). The patents allotted for nanotechnology have been increasing significantly. China is leading the countries in number of patents being awarded (see Fig. 3). The energy sector has also gotten a major boost due to nanotechnology, and the growth has been phenomenal in the energy sector due to nanotechnology worldwide (see Fig. 4). Many other industrial sectors also show improvement and growth (see Fig. 5), including nano-optics, nanobiotechnology, nanomaterials, nanomedicine, and other industrial products. The transition from research and development to industrial output is the last aspect to analyze when measuring the development of nanotechnology. The economic significance can be measured by market volume and shares but is not easily identified due to its presence in a wide range of industries (10). There are very different projections of market volume from numerous resources looking at the same time period from 2000 to 2015 (10). The different forecasts have very different market values at the end of this trend, but they all show a substantial increase in the market in 2010. The most optimistic projection for 2015 is by Lux Research in 2004, which projected a market value at 2.6 trillion; the moderate value, 1 trillion, is predicted by the National Science Foundation (NSF) 264 Rapaka ET AL. Figure 2. Growth in the number of patents worldwide, according to the European Patent Office. (10). Both of these projections predict a period of substantial market growth in nanotechnology followed by an increase in market value, highlighting the increasing economic significance of nanotechnology. The transformation of technology is also reflected in the number of nanotechnology articles written in different languages (Table 1) and the 10 conferences with highest number of nanotechnology articles (Table 2). ECONOMIC IMPACT OF NANOTECHNOLOGIES Fields of Major Development and Application of Nanotechnologies The exclusivity of nanoparticle technology lies in the quantum effects and properties of particles being constructed at a nanoscale (1–100 nm). Properties such as melting point, fluorescence, Figure 3. Number of patents given country-wise, showing China leading the competition based on number of patents allotted to Chinese companies and scientists. LEADERSHIP ROLE OF NANOTECHNOLOGY INNOVATION 265 Figure 4. Growth of nanotechnology innovation in the energy sector (7). chemical reactivity, conductivity, and magnetic permeability deviate from that of the bulk material, providing scientists with unique materials with a variety of applications in commercial and biotechnological fields, such as commercial goods, electronic technology, sustainable energy, and medical technology (22). The ability to engineer materials with specific properties by tailoring particles at a nanoscale is very useful in creating a variety of polymers that can be used in sporting goods, fabrics, and ceramic coatings to reduce weight and increase durability (22). Nanotechnology in electronics is used to make more powerful transistors, polymer films used in television and computer displays, and many other materials used in memory chips and other small household electronics. Nanotechnology is even breaking into the energy industry to improve solar panels, batteries, and windmill blades, and speeding up the process of development of clean energy, and medical technology takes advantage of the small scale of nanoparticles for applications in drug delivery and molecular imaging (20). For example, today, in our electricity-dependent world, batteries play a very important role in many different types of equipment, ranging from cellphones to hybrid car batteries. Using nanomaterials, a rapid discharge battery has been proposed and is expected to become Table 1. Number of Nanotechnology Articles Written in Different Languages Figure 5. Patents granted in nanotech by sector (18). Language No. of Nanotechnology Articles Percentage English Chinese Japanese German Korean French 821,684 14,999 1,048 665 481 471 97.67% 1.78% 0.13% 0.08% 0.06% 0.06% Read more: An overview of journals publishing nanotechnology articles http://www.nanowerk.com/nanotechnology-news/ newsid=35778.php#ixzz3FNGmKb5x 266 Rapaka ET AL. Table 2. Ten Conferences With Highest Number of Nanotechnology Articles No. 1 2 3 4 5 6 7 8 9 10 No. of Nanotechnology Articles Conference Title Spring Meeting of the European Materials Research Society International Conference on Nanoscience and Nanotechnology International Conference on Solid State Devices and Materials Spring Meeting of the European Materials Research Society Meeting of the European Materials Research Society International Conference on Luminescence and Optical Spectroscopy of Condensed Matter 6th International Conference on Nanoscience and Technology 16th International Conference on Science and Technology of Synthetic Metals 2000 International Conference on Magnetism 2003 10th International Conference on Modulated Semiconductor Structures 489 387 350 258 230 211 202 198 197 195 Read more: An overview of journals publishing nanotechnology articles http://www.nanowerk.com/ nanotechnology-news/newsid=35778.php#ixzz3FNH50pjk available on the market within a few years (13). Another example is the development of the nontoxic two-photon photodynamic nanoparticle that can be used for tumor debulking surgery (8,15). Thus, nanotechnology is being utilized in a wide variety of commercial fields, but to assess the economic impact, we must look at how the technology is affecting the global economy and explore the geographical diversity of the technology being developed. Over the past century, much of the growth in the US economy has been in the high-value technology industries, such as information technology and biotechnology, whose expansion can be driven by advances in nanotechnology, as well as increased incorporation of nanotechnology to increase the efficiency of novel products (6). Many of these advances are due to the federal investment in nano­ technology-related research and the development program NNI. The NNI aims to create positive economic returns through increased jobs, trade, and an increased number of jobs in nanotechnology industries (6). A report by Lux Research, Inc., comparing gross economic output of nanotechnology and its impact on the economy, as well as predicting future trends, estimates that nanotechnology accounted for $158 billion in global product revenue and predicted that by the year 2015, nanotechnology would account for 2.6 billion in global product revenue, which would account for 15% of global gross manufacturing output (5,6). The large increase in commercialization of nanoparticle technology could have a tremendous impact on the various industries and must be met with enhanced workforce training and education, as well as the creation of new jobs. Globalization and Geographical Diversity of Major Contributors in the Field of Nanotechnology The US has been the leading contributor in the field of nanotechnology for the last two decades. The establishment of the NNI was one of the major steps toward the growth of nanotechnology in the US, and since then more countries have developed their own initiatives that will contribute to their presence in the global market (5,9). Influential studies have predicted nanotechnology as a key technology that will drive global competition, with the estimated global market value for nanotechnology in 2010 at $15.7 billion expected to rise to nearly $19.6 billion in 2015 (4). Japan, one of the world leaders in nanotechnology advancement, has devoted its research and development to five major fields: information and telecommunications, environment and energy, medical and biotechnology, manufacturing, and nanomaterials (14). The Nanomaterials Working Group (NWG) suggested that Japan focuses on these fields in particular in hopes of transferring its basic research into industrial rejuvenation. Thus, in Japan, similar to the NNI in the US, NWG provides the platform for LEADERSHIP ROLE OF NANOTECHNOLOGY INNOVATION nanotechnology development. On the other hand, South Korea demonstrated remarkable growth in its contribution to nanotechnology within the last decade, mostly via the initiative of the industry itself. Korea is one of the top countries in numbers of publications and patents where major patent applicants include well-known companies such as Samsung Electronics Co. and LG Electronics (5,6). Taiwan experienced almost exactly the opposite situation. Owing to a lack of large companies that could afford research and development of nanotechnologies, government regulation has successfully funded and steered the industry toward development of nanomaterials, securing Taiwan’s place in electronics and nanotechnology (11). Taiwan demonstrated how government has assisted the development of new technology and helped overcome financial barriers by providing incentives to the industry. Progress of nanotechnology has been primarily led by countries who are members of the Organisa­ tion for Economic Co-operation and Development (OECD), including the US, Japan, South Korea, Germany, Canada, Netherlands, France, Mexico, and the UK, among others (6). The objectives of the OECD are to provide solutions in high technology, applications of nanotechnology in pressing concerns in developing countries, such as water purification, agriculture, and energy, and to inspire developing countries to invest their resources in the development of nanotechnology (4). Outside of the OECD countries, China and India have made great strides in the field of nanotechnology to establish competency in this high-technology area (4). China has demonstrated the most rapid growth rate in publications and patents (5). As far as the international market for nanotechnology products and processes, there are a total of 1,317 products/ product lines in the W. Wilson database. Of these, the US leads the pack with 587 products followed by Germany, Korea, China, and Japan with 168, 126, 55, and 51 product lines, respectively. The majority of these products (60%) are in the health and fitness sector, but other areas that dominate the global market include home and garden, the automotive sector, and medical technology-based applications (4). One of the strengths of China’s contribution to nanotechnology is the development of basic nanomaterial coatings that can be made into carbon nanotubes for bulletproof vests and antielectromagnetic material. 267 India has been improving technologies in medicine and the development of technologies for sustainable energy using efficient semiconductors used in solar cells as well as carbon fiber used in rotating fans that generate wind power. Active participation in advancement of the field internationally will create a global market for nano­ technologies. In a sense, the progress in nanotechnology creates a race to secure patents and a foothold in the market, which provides some security for future business. The geographical diversity may create additional challenges as the governments may seek different levels of regulation of trade and development in their own country. At this time, it may be wise to learn from the lessons of marketing globalization. The processes and regulations specific to nanotechnology would have to be established. Nanotechnologies for application in healthcare are expected to come under more severe scrutiny of regulation from the government and may be the most challenging to establish (3). GOVERNMENT REGULATIONS The increased production of nanoparticles and nanomaterials and increased use in commercialized products has produced a new issue dealing with regulation of this technology with regard to environmental, health, and safety concerns (31). Although there is little consensus about the risk of these technologies, certain toxicological data reports have led to concerns about the effectiveness of the current forms of regulation on nanotechnology (31). The new approach, nanospecific regulation, is currently being carried out by existing regulatory agencies. Currently, the regulation of nanoparticle technology has been delegated by the OECD to two parties: the Working Party on Manufactured Nanomaterials (WPMN) and the Working Party on Nanotechnology (WPN). The WPMN’s agenda includes the creation of a database on human health and environmental safety research, safety testing of manufactured nanoparticles, and developing risk assessment approaches to put various nanomaterials through (31). The WPN objectives seek to involve the public through outreach activities that educate about the role of nanotechnology in addressing global challenges and to facilitate international research collaborations (31). The International Risk 268 Rapaka ET AL. Governance Council (IRGC) and the International Council on Nanotechnology (ICN) are just two of the many governing bodies focused on the development and governance of nanotechnologies. For the full potential benefits of nanotechnology to be commercialized, many of the regulatory challenges associated must be addressed so that growth will not be affected. The pressing long-term solution is to tackle the unknown scientific and systemic aspects of the technology (31). However, the need to uncover these uncertainties should not inhibit the growth of nanotechnology, as the multiparty jurisdiction can provide a framework for managing risks (31). CONCLUSION AND FUTURE PERSPECTIVES Nanotechnology is a broad term describing a collection of different technologies and processes that involve nanoscale particles whose properties deviate from bulk material, thus allowing them to be engineered for a variety of applications. Nanoparticle material is used in a variety of commercialized goods from polymers used in fabrics to sporting goods, helmets, cosmetic products, and electronic products. In addition to these industrial uses, there are many biomedical applications in targeted drug delivery. The growth of nanotechnology is dependent on its economic impact, innovation, and government regulations. The economic impact can be measured in the many fields of development and applications as well as the growth of nanotechnology on a global scale. Nanotechnology innovation can be measured by examining the increase in publications, patents, and market growth. The NNI is considered the starting point in the race for the development of nanotechnology and played a major role in urging other countries to develop their own forms of public funding. As developed countries invest in nanotechnology for the advancement of higher technologies, developing countries tend to channel their resources toward advancing nanotechnology for its uses in pressing concerns such as water purification and agriculture. The future of nanotechnology, its growth and development will be reliant on many factors. With continued public and private funding, the research and development in the field of nanotechnology will continue to expand. Global competition between the US and China will push the advancement of the field, and the future publications and patents will only further increase. The commercialization of nanotechnology is still in its infancy, however, and the expectation is that it will continue to grow and become a larger part of the global economy. As nanotechnology becomes a larger part of the economy, more regionally technological areas will work with universities to collaborate and invest in their own research and development as well as the development of a future nanotechnology-savvy workforce. As with any rapidly expanding field, societal concerns (including health and environmental) will present a challenge to the advancement of commercial use of nanotechnology. However, as nanotechnology moves into a phase of substantial market growth, there will need to be an increased investment placed on researchbased on evaluating the risks associated with emerging technologies and standardization of regulations of the new nanotechnologies. ACKNOWLEDGMENT: The authors declare no conflict of interest. REFERENCES 1. Allhoff, F. 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