The breast Cancer Research Foundation Founded in 1993 Pink Press ® ® Myra Biblowit, Dr. Larry Norton, Evelyn Lauder and President Bill Clinton PHOTO: Julie Skarratt PHOTO: Rob Rich winter 2011 Pierce Brosnan and Judy Craymer BCRF 2010 Awards Luncheon Honoring our Super Heroes BCRF’s Annual Symposium and Awards Luncheon on October 27 was an exceptional occasion for a variety of reasons. Drawing more than 1,000 guests to The Waldorf=Astoria in New York City, the event raised over $2 million, and the Foundation awarded $33 million in grants to 172 researchers from around the world. It was especially poignant as the morning Symposium was dedicated to Josie Robertson, a beloved member of the BCRF Board of Directors who passed away in June. Evelyn Lauder described Mrs. Robertson as “an inspiration” who was fully committed to finding prevention and a cure for breast cancer since day one. Surprising the audience with his presence, former President Bill Clinton welcomed the guests. “Every time I see a pink ribbon, it is very personal to me,” said Clinton, who spoke candidly about how breast cancer has impacted his life. As President, Clinton signed the Breast and Cervical Cancer Prevention and Treatment Act of 2000, which increased healthcare coverage for patients as a way to prevent families from being driven to bankruptcy because of medical costs. In his private role as the son of a mother who died from breast cancer, he articulated the all-too-familiar toll that the disease exacts on families. Sharing these intimate details, Clinton inspired everyone in the audience as to the reasons why supporting research must take center stage in the effort to prevent and cure breast cancer. continued on page 3 A Message from Evelyn Lauder, Founder and Chairman This October, at our annual Symposium and Luncheon, we honored our “Super Heroes”; the 172 brilliant medical scientists from around the world who are changing the face of breast cancer. BCRF’s Super Heroes continue to gain momentum and are saving more lives each year. They are the best and the brightest, and it is a privilege to raise funds to support their enormous talent. Since 1993, BCRF has raised over $300 million to support research. I am so proud that we were able to award $33 million in grants to this year’s group of researchers. They represent 12 countries across the United States, Canada, Latin America, Europe, the Middle East and Australia. People often praise me for my work at BCRF, but I truly know that all the praise should be directed to two groups – our wonderful staff at the Foundation and our Super Heroes: the men and women who dedicate their life’s work to finding an end to this disease or ensuring that we have ways to prevent breast cancer in the near future. When you talk to these scientists, you can’t help but feel their energy, their excitement, their enthusiasm, and their commitment to their research projects. They are our fuel. We are so close to living in a world where breast cancer is obsolete. With your continued support, our Super Heroes can make this a reality. Wishing you a healthy and happy 2011. Evelyn H. Lauder PHOTO: Wire Image.com Supporting BCRF means you are supporting the very best science in breast cancer in the world. BCRF continues to be one of the most efficient organizations—having received 4 stars from Charity Navigator for nine consecutive years, BCRF has outperformed 99% of more than 5,500 evaluated charities. Furthermore, the Foundation is consistently listed as an “A+” charity by The American Institute of Philanthropy. Dr. Joan Brugge and Anne Keating Dr. Andrea Richardson, Jane and Neil Golub Dr. Michael Press, Joanne Smith; Drs. Susan Horwitz, Hayley McDaid, Sofia Merajver and Adrian Harris Tommy and Dee Hilfiger Cynthia Lufkin and Muffie Potter Aston The breast Cancer Research Foundation® Dr. Annette Stanton, Kay Krill, Dr. Carol Fabian, Evelyn Lauder and Dr. Dawn Hershman UNLESS OTHERWISE NOTED PHOTOS: Julie Skarratt Perri Peltz, Danielle Ganek and Gigi Mortimer PHOTO: Rob Rich Gail Hilson and Anne Sitrick PHOTO: Rob Rich PHOTO: Rob Rich Mike Tucci, Dr. Robert Schneider, Myra Biblowit; Drs. Silvia Formenti and Judy Garber; Evelyn Lauder and Todd Kahn PHOTO: Rob Rich winter 2011 2 Myra Biblowit set the stage for The Humanitarian Award, now named in memory of Sandra Taub, daughter of devoted and steadfast supporters of the Foundation, Arlene and Joseph Taub. Actor Pierce Brosnan presented the 2010 Sandra Taub Humanitarian Award to Judy Craymer, the creator and producer of the global phenomenon Mamma Mia! Describing her as “one of those beautiful women who would change your life forever,” Brosnan recounted the exhilarating experience of working with Craymer – in spite of the fact that she had dressed him in tights. Craymer has been a staunch supporter of BCRF since 2001, following a serendipitous meeting with Evelyn Lauder on a transAtlantic flight. Inspired by their meeting, Craymer created the “Rock Chick Supremo” t-shirt, which is sold at all Mamma Mia! productions world-wide and has generated over $750,000 for BCRF. Impressing everyone in the audience with her sincerity in accepting the award, Craymer spoke directly to the BCRF grantees in the audience. “Life is about second chances, and that is what you give us. You are, after all, the rock stars of medical science.” PHOTO: Rob Rich Mrs. Lauder thanked everyone in the room for supporting our Super Heroes— the men and women who are working tirelessly to realize a cure for breast cancer in our lifetime. She then turned the program over to Dr. Larry Norton, who presented the 2010 Jill Rose Award to Dr. Angela Hartley Brodie. 3 Marshall Rose; Drs. Angela Hartley Brodie and Larry Norton; and Wendi Rose The Symposium and Awards Luncheon was made possible by underwriters Roz and Les Goldstein, Terry and Katie Wheatley of Tough Enough to Wear Pink, and Evelyn and Leonard Lauder. The Foundation also wishes to thank Co-Chairmen Roberta Amon, Anne Bass, Betsy Green, Joanne de Guardiola, Ronnie Heyman, Gail Hilson, Evelyn Lauder, Bonnie Englebardt Lautenberg, Cynthia Lufkin, Gigi Mortimer, Wendi Rose, and Arlene Taub. PHOTO: Rob Rich Alex Robertson and Lizzie Tisch Jamee Gregory, Audrey Gruss, Anne Eisenhower Flöttl Dr. Michael Sporn, Tom Hipwell and Dr. Karen Liby Caryn Zucker and Tory Burch Dr. Kenneth Offit, Arlene Taub and Dr. Walter Willett PHOTO: Rob Rich Jenny Paulson and Joanne de Guardiola Science The Complex Role of Hormones in Breast Cancer Development and Treatment: A View from the Experts With an all-star panel consisting of BCRF’s Executive Board of Scientific Advisors and the 2010 Jill Rose Awardee, this year’s Symposium focused on The Many Faces of Hormones and Breast Cancer: Expert Views of Causation, Treatment and Prevention. The experts traced the early path of treatments for hormone-receptor-positive breast cancer, which is the most frequently occurring type of breast cancer, continuing on to new lines of scientific inquiry emphasizing individualized treatment and preventive care. This signature event brought together a breast cancer brain trust, including 140 of the 172 BCRF 2010-2011 grantees, to help an overflow audience of more than 500 guests get to the bottom of hormones – specifically estrogen – and breast cancer and what people can do to minimize risk and maximize treatment options. The scientists reminded the audience that the presence of estrogen in itself is not a risk factor for breast cancer, but that about 80% of breast cancers express the estrogen receptor, whose growth is fueled by estrogen. winter 2011 4 PHOTO: Rob Rich At the panel’s center was Angela Hartley Brodie, PhD (Professor of Pharmacology and Experimental Therapeutics at the University of Maryland), recipient of the 2010 Jill Rose Award for Distinguished Scientific Achievement, in recognition of her seminal research in the development of aromatase inhibitors, drugs that stop the production of estrogen. Joining her on the panel from BCRF’s Executive Board of Scientific Advisors were BCRF’s Scientific Director, Larry Norton, MD, Director of Breast Cancer Programs at Memorial Sloan-Kettering Cancer Center; Nancy Davidson, MD, Director of the University of Pittsburgh Cancer Institute; Peter Greenwald, MD, Dr.PH, Director of the Division of Cancer Prevention and Control at the National Cancer Institute; and Gabriel Hortobagyi, MD, Chairman of the Department of Breast Medical Oncology at the University of Texas, MD Anderson Cancer Center. Clifford Hudis, MD, BCRF Scientific Advisory Committee Chair and Chief of Breast Cancer Medicine at Memorial Sloan-Kettering Cancer Center, moderated the lively presentations. When Dr. Brodie, this year’s honoree, began her research in the 1960s, very little was known about the relationship between estrogen and breast cancer. Scientists knew that there was a connection; Dr. Hortobagyi provided a historical example dating to the 1890s, when it was noted that surgical removal Drs. Clifford Hudis, Angela Hartley Brodie, Gabriel Hortobagyi, of ovaries of young breast cancer patients seemed to “cure” Nancy Davidson, Peter Greenwald and Larry Norton some of these women of the disease. Building on later work that elucidated more precisely the link between estrogen and breast cancer, Dr. Brodie’s investigations spurred the development of aromatase inhibitors, used in post-menopausal women with breast cancer to stop the production of estrogen. Thanks to her work, there are three aromatase inhibitors on the market today and they are used to both treat breast cancer and prevent its return after surgery. They may even have a role in prevention, and research studies exploring this are underway. Dr. Brodie continues to focus on resistance to the aromatase inhibitors, since as many as one-third of breast cancer patients do not respond to hormone therapy and a significant percentage of ER+ tumors eventually become less responsive. Drs. Hortobagyi and Davidson each spoke about their work. The general guideline for treating women with ER+ breast cancer calls for tamoxifen when they are pre-menopausal and aromatase inhibitors after menopause. This is a good example of the specificity that researchers have been able to achieve; however, they have not yet reached the ultimate goal of truly individualized therapy which might include patient-specific treatment selection based not only on the characteristics of the tumor but also on other factors related to the patient as a whole. Dr. Davidson then spoke of the need to address challenges facing survivors who have to confront not only the possibility of their cancer’s recurrence and metastasis but also the long-term effects of therapeutics, such as chemo- or radiation therapy. Hormone therapies are typically associated with fewer side effects but studies continue to find even safer ways to use them. Dr. Greenwald shared with the audience his expertise on cancer prevention, telling them that “breast cancer prevention starts with your life habits, including diet and exercise.” He explained that data from the first generation of prevention studies showed that lifestyle changes, such as weight loss and reduced consumption of alcohol, lower the risk of developing cancer. With respect to weight, studies have shown that obesity increases estrogen and inflammation levels, the elevation of which exposes women to greater risk of breast cancer. As far as environmental factors that have been attributed to the incidence of breast cancer, Dr. Greenwald pointed out that it is very difficult to measure the level of toxins in a population, so direct cause and effect has not yet been demonstrated. The breast Cancer Research Foundation® The Symposium concluded with a lively exchange among the audience, panelists, and many of the BCRF grantees. Part of the discussion clarified the distinction between hormonal treatment for breast cancer, which works by blocking or lowering estrogen levels in the body, and hormone replacement therapy (HRT) after menopause, use of which has fallen off since clinical trials demonstrated that the estrogen in HRT can increase the risk of breast cancer development. HRT did not provide many of the benefits people thought it would. “Cancer is complex but has an Achilles’ heel, and it is our job to find its weaknesses and exploit them,” summarized Dr. Norton. “Are there easy answers? No. Are there hints? Absolutely!” Research Retreat for Grantees The enthusiasm at the Symposium matched the energy at the scientific retreat for BCRF researchers that took place the day before. The annual retreat, sponsored by Muriel Siebert, followed a “think tank” format, and researchers participated in one of six sessions: Biomarkers; Cancer Stem Cells and Cancer/Stroma Interactions; Therapeutic Targets/Targeted Therapeutics; Cancer Susceptibility Genes; Molecular Classification, Prognostication and Prediction; and Prevention and Survivorship. In each group, investigators brainstormed the most important “next steps” in breast cancer research, and then the entire group met to hear summaries from group moderators. As a take-away to be shared among the participants, Dr. Norton requested that each researcher submit a sentence describing her or his “Zen wisdom” about the most important research advance discussed, and another describing the greatest impediment to progress. Responses to date have centered on a few main themes and concerns, including the as-yet unrealized goal of therapy that is truly personalized, the need to better unify research on the discovery of new biomarkers for breast cancer, and more recognition of the very broad genetic diversity within individual breast cancers. This event embodies BCRF’s commitment to encouraging dialogue and fostering collaboration among breast cancer researchers from all corners of the globe. Grantees in the News In June 2010, Kathryn B. Horwitz, PhD, Distinguished Professor at the University of Colorado School of Medicine, received the Fred Conrad Koch Award, the highest honor bestowed by The Endocrine Society, in recognition of exceptional contributions to the field. Dr. Horwitz has also been chosen to receive the 10th Rosalind E. Franklin Award for Women in Science from the National Cancer Institute to be presented in January 2011. In September, President Cristina Fernandez de Kirchner of Argentina formally launched the National Cancer Institute of Argentina and appointed Eduardo L. Cazap, MD, PhD, Deputy Director of the Institute. Dr. Cazap is President and Founder of Latin American & Caribbean Society of Medical Oncology (SLACOM) and President of International Union Against Cancer. Silvia C. Formenti, MD was honored at the NYU Cancer Institute Gala on October 5, for her contributions to cancer care and research. Dr. Formenti is the Sandra and Edward H. Meyer Professor of Radiation Oncology, the Chair of the Department of Radiation Oncology, and co-leader of the Breast Cancer Research Program at NYU Langone Medical Center. Two BCRF grantees were elected as new members of the Institute of Medicine (IOM) in October. Charis Eng, MD, PhD, Professor of Genetics and Chair and founding Director of the Genomic Medicine Institute of the Cleveland Clinic, and Titia de Lange, PhD, the Leon Hess Professor at The Rockefeller University, joined 63 fellow scientists and five foreign associates as IOM’s Class of 2010. As the health arm of the National Academy of Sciences, the IOM functions as an authoritative body advising both decision makers and the public, with the underlying mission of improving human health. In November, Mary-Claire King, PhD received the Pearl Meister Greengard Prize from The Rockefeller University for her research which has advanced the science of genetics and improved medicine for the benefit of humankind. Dr. King also was awarded the 2010 Double Helix Medal from Cold Spring Harbor Laboratory for her major contributions to understanding the genetics of breast cancer. Sharing the same honor, Evelyn Lauder was recognized for her efforts in raising aware ness and support for clinical and translational research on breast cancer at medical institutions across the globe. On November 18, José Baselga, MD, PhD was awarded the 2010 Queen Sofía Spanish Institute’s Gold Medal, representing Spain’s leadership in the area of cancer research. Dr. Baselga, Associate Director of the Massachusetts General Hospital Cancer Center and Professor of Medicine at Harvard Medical School, was previously the Director of the Vall d’Hebron Institute of Oncology in Barcelona. 5 Q&A with Dr. Carol Fabian Professor of Internal Medicine Kansas Masonic Cancer Research Chair Director, Breast Cancer Prevention and Survivorship Centers University of Kansas Medical Center Kansas City, Kansas Q: Tell us about yourself as a scientist and how you became interested in breast cancer research. Did you ever seriously consider another kind of career than that of the sciences? My interest in science dates back to my early college days. I was first attracted to psychology, then microbiology, and finally medicine. I never did consider another type of career other than the sciences. winter 2011 6 I became interested in breast cancer research during fellowship training in oncology. Although I was interested in a variety of different types of cancer, I was particularly drawn to breast cancer because it seemed like so many young women at the time were being affected by the disease. Q: What factors have motivated you to continue studying this field? My interest in risk assessment and prevention research came about 15 years after I started treating cancer patients. When I completed training in the 70s there was tremendous excitement in oncology. We thought almost every woman with early breast cancer could be cured with the right combination of adjuvant treatment. That is still the basic premise of treatment research and we have made tremendous strides in the past 35 years. However, after a decade and a half of oncology practice, it became very painfully obvious to me that many women who had early breast cancer were not going to be cured despite doing everything “right.” That is, they got their yearly mammograms, the cancer seemed to have been detected early, and they received aggressive adjuvant therapy; yet, many still relapsed and died. In addition, many women who did appear to be cured had lingering side effects which reduced their quality of life. Prevention of breast cancer by blocking or reversing precancerous changes with medication rather than waiting for it to happen seemed to make sense. The early days (circa 1990) of working in risk assessment and prevention were a little tough. We needed tools to predict who was at highest short-term risk and who was likely to respond to therapy. My team and I refined a fine-needle aspiration (FNA) technique so that we were able to get representative breast tissue, kind of like a “pap smear” for the breast tissue, to test for signs of precancerous change and, thereby enabling doctors to more accurately assess a person’s short-term risk of developing breast cancer and target appropriate women for prevention treatment. While this made infinite sense to us, it did not to most others. Conventional wisdom was that you did not put a needle into a woman’s breast unless you had a lump or other abnormality to aim at. We were, however, eventually able to show that for women who had a family history of breast cancer or who had a prior precancerous biopsy, random sampling of her breast tissue by FNA could more accurately predict short-term risk than by using risk models alone. Once we were able to demonstrate that we could better predict which women were at high short-term risk of developing breast cancer, the challenge became to apply clinical prevention interventions. Concerns over possible side effects keep many women from using standard prevention options such as tamoxifen, or raloxi fene, or even prophylactic surgery. Consequently, we began early-phase testing of interventions with fewer effects using the FNA technique to sample tissue before and after the intervention. One of our goals was to make the aspirations as comfortable as possible so that the patients would come back and get them again. Q: Briefly describe your BCRF-funded research project. What are some laboratory and/or clinical experiences that inspired your work? What are your primary goals for this research? My first BCRF project, which is still ongoing, is developing new tissue-based biomarkers for women who are at increased risk of breast cancer but whose tissue samples obtained by FNA did not have a high growth (or proliferation) rate even though it might have some atypical looking cells. These women are primarily post-menopausal, overweight women who are not on hormone replacement therapy. Although these women have very low proliferation rate in their benign tissue, they can still develop cancer over time. Part of the reason is that inflammatory cytokines and adipokines may promote survival and more aggressive behavior of atypical cells. In conjunction with Dr. Stephen Hursting, another BCRF researcher at the University of Texas, we started looking at inflammatory markers in breast tissue and blood. We found that we could measure the inflammation markers reliably in the breast tissue. We are currently trying to make sure that in the absence of an intervention (i.e., drugs or weight loss, etc.) that these markers are still consistently expressed over time. The breast Cancer Research Foundation® Building on the first two years of our BCRF research, we have developed new pilot trials (one of which is funded by BCRF) using high-dose omega 3 fatty acids and have proposed trials using energy balance interventions. Q: How close are we to preventing and curing all forms of breast cancer? At the time I completed my training in the mid-1970’s, 40% or more of the women who developed breast cancer were dying from it. Now fewer than 20% of women, who were undergoing regular screening at the time their breast cancer was discovered, will ultimately die of their disease. Although that figure is still too high, the change over 35 years is amazing. For prevention, we have identified drugs that will reduce by half the 5-to-10 year risk of developing breast cancer. The problem is few risk-eligible women will take them. So, I think we have to look at multiple prevention strategies, emphasizing interventions likely to be attractive to women at different stages of their life. The emphasis should be on things that women can do themselves which do not require extensive medical monitoring. These interventions ideally should make them look better and feel better (like diet and exercise). We also need to give a map and a toolbox such that they can accomplish their goals. I see prevention going in that direction. Q: In your opinion, how has BCRF impacted breast cancer research? BCRF has impacted breast cancer research in at least two very important ways. One is that the organization stimulates cross-collaboration by bringing together established breast cancer researchers from various fields. The collaboration between Dr. Hursting’s and my group is an example. BCRF is also unique in that it supplies funds needed to develop the clinical and translational tools and the preliminary data needed to perform research. Having the tools and pilot data accelerates the pace of breast cancer research. Read the entire Q&A on www.bcrfcure.org. BCRF Hosts Conference in Israel on Inherited Breast and Ovarian Cancer On November 18 and 19, BCRF co-hosted its first international scientific meeting, a symposium in Tel Aviv, on Clinical Dilemmas in Management of Breast and Ovarian Cancer in BRCA Carriers. BCRF’s participation was made possible by a contribution from Advisory Board member Roslyn Goldstein and her husband, Les. Chaired by BCRF Scientific Director, Larry Norton, MD, the conference was attended by more than 150 medical oncologists, surgeons, radiation oncologists and other medical professionals from the Mideast, Europe, Australia and North America; session chairs included BCRF grantees Drs. Judy Garber (Boston) and Fatima Cardoso (Lisbon), and presenters Dr. Judy Garber included Drs. Ephrat Levy-Lahad (Jerusalem) and Moein Kanaan (Palestinian Authority). In her keynote, BCRF grantee Mary-Claire King, PhD (Seattle) credited BCRF support for studies conducted jointly in the US, Israel and the Palestinian Authority, as responsible for the creation of a data pool to sequence all critical genes involved in breast cancer development and to identify mutations known to be deleterious. She cited the complexity of the challenge to unravel the genetic basis of the disease: while there are three known mutations of Ashkenazi origin, there are 1,000 known mutations on BRCA1 and an equal number on BRCA2. Drs. Fatima Cardoso, Mary-Claire The content of the presentations reflected the collaborative spirit of BCRF research. King, Larry Norton; Peg Drs. Levy-Lahad and Kanaan described their joint efforts with Dr. King to determine Mastrianni; Drs. Suheir the genetic basis of inherited predisposition to breast cancer in the Palestinian Arab Lolas-Hamame and Ephrat Levy-Lahad population, and to create the infrastructure for providing cancer genetics services to these women. Dr. Garber provided an overview of the search for new treatments that can be used as chemopreventive agents for individuals at high risk. She cited work by BCRF grantees at Dartmouth, Drs. Michael Sporn and Karen Liby, who have shown in the laboratory that PARP inhibitors have potential for use in prevention. In closing the meeting, Dr. Norton said that breast cancer research is “a model for collaborative effort; there are relatively few areas where there is such integration between laboratory science and clinical practice.” Highlights from the conference are on www.bcrfcure.org 2011 Unsung Hero Needed On April 14, the Unsung Hero Award, established by Roz and Les Goldstein, will be presented at the NYC Hot Pink Party to a special individual who has been a source of support, hope, humor, strength and comfort to a woman facing breast cancer. Send nominations to Myra Biblowit by February 1: myrabib@bcrfcure.org or 646-497-2601 7 2010 - 2011 Grantees Albert Einstein College of Medicine New York, NY Cold Spring Harbor Laboratory Cold Spring, NY Jill Bargonetti, PhD Made possible by Estée Lauder Memorial Sloan-Kettering Cancer Center New York, NY Rachel Hazan, PhD The First Step Award, made possible by QVC & Fashion Footwear Charitable Foundation Michael H. Wigler, PhD The Play for P.I.N.K. Award Indiana University School of Medicine Indianapolis, IN Robert Benezra, PhD The Play for P.I.N.K. Award Columbia University Mailman School of Public Health New York, NY Susan E. Clare, MD, PhD Made Possible by ULTA Monica N. Fornier, MD Regina M. Santella, PhD Made possible by Aveda Kathy D. Miller, MD Made possible by Ann Taylor Stores Corporation Alan N. Houghton, MD The Peter Jay Sharp Foundation Award Thomas E. Rohan, MD, PhD Mary Beth Terry, PhD Made possible by Aveda George W. Sledge, MD Arizona State University The Biodesign Institute Tempe, AZ Columbia University Medical Center New York, NY Susan B. Horwitz, PhD Made possible by Delta Air Lines, Inc. Joshua LaBaer, MD, PhD Baylor College of Medicine Houston, TX C. Kent Osborne, MD Rachel Schiff, PhD Beth Israel Deaconess Medical Center/ Harvard Medical School Boston, MA Lewis C. Cantley, PhD Dawn Hershman, MD, MS Made possible by Ann Taylor Stores Corporation Dana-Farber Cancer Institute/Harvard Medical School Boston, MA Judy E. Garber, MD, MPH The Coach Award Anna Maria Storniolo, MD Made possible by ULTA INSERM, Centre René Huguenin Paris, France Rosette Lidereau, PhD Institut Jules Bordet Brussels, Belgium Hedvig Hricak, MD, PhD Made possible by Macy’s Clifford Hudis, MD Johanna A. Joyce, PhD Philip O. Livingston, MD Shanu Modi, MD ASCO Cancer Foundation Larry Norton, MD Martine J. Piccart-Gebhart, MD, PhD The Peter Jay Sharp Foundation Award Breast International Group/TRANSBIG The First Step Award, made possible by QVC Made possible by Roche & Fashion Footwear Charitable Foundation J. Dirk Iglehart, MD Made possible by Price Chopper William G. Kaelin, Jr., MD Stuart J. Schnitt, MD Nancy U. Lin, MD The Housewares Charity Foundation Award The Play for P.I.N.K. Award Nadine M. Tung, MD David M. Livingston, MD The Housewares Charity Foundation Award Ursula A. Matulonis, MD Bethlehem University Bethlehem, Palestinian Authority Kornelia Polyak, MD, PhD Moein Kanaan, PhD Brigham & Women’s Hospital/Harvard Medical School Boston, MA Andrea L. Richardson, MD, PhD Made possible by Price Chopper Zhigang Charles Wang, MD, PhD PHOTO: Rob Rich winter 2011 8 Hayley McDaid, PhD Made possible by Delta Air Lines, Inc. Teresa Gilewski, MD Ross Berkowitz, MD Dartmouth Medical School Hanover, NH Christos Sotiriou, MD, PhD Monica Bertagnolli, MD On behalf of Cancer and Leukemia Group B Karen T. Liby, PhD Made possible by Nestlé Pure Life Institute of Cancer Research UK London, UK Michael B. Sporn, MD Made possible by Nestlé Pure Life Alan Ashworth, BSc, PhD, FRS Made possible by Hard Rock International Neal Rosen, MD, PhD The Joseph and Arlene Taub Foundation International Breast Cancer Research Award Foundation Columbus, OH Charles L. Sawyers, MD Cancer Institute of New Jersey/ University of Medicine & Dentistry of New Jersey New Brunswick, NJ Duke University Durham, NC Bruce G. Haffty, MD The Play for P.I.N.K Award John A. Olson, Jr., MD, PhD On behalf of ACOSOG Kim Hirshfield, MD, PhD David Ota, MD On behalf of ASOCOG Arnold J. Levine, PhD The Institute for Advanced Study CHS National Cancer Control Center Carmel Medical Center Haifa, Israel Gad Rennert, MD, PhD Champalimaud Cancer Center Lisbon, Portugal Fatima Cardoso, MD Breast International Group/NABCG Children’s Hospital/Harvard Medical School Boston, MA Emory University on behalf of NABCG/Breast International Group Atlanta, GA William C. Wood, MD Made possible by Genentech Harvard Medical School Boston, MA Marsha Moses, PhD Made possible by Clinique Joan S. Brugge, PhD Made possible by Bloomingdale’s Zoltan Szallasi, MD Harvard School of Public Health Boston, MA Cleveland Clinic Cleveland, OH The Methodist Hospital Research Institute Houston, TX Johns Hopkins Bloomberg School of Public Health Baltimore, MD Jenny Chang, MD Johns Hopkins University School of Medicine Baltimore, MD Pamela J. Goodwin, MD, MSc, FRCPC Mount Sinai Hospital University of Toronto Kala Visvanathan, MBBS, FRACP, MHS Toronto, Ontario, Canada Mount Sinai School of Medicine New York, NY Stuart A. Aaronson, MD Vered Stearns, MD The Housewares Charity Foundation Award Made possible by The Estée Lauder East Coast Field National Surgical Adjuvant Breast and Bowel Project (NSABP) Antonio C. Wolff, MD Pittsburgh, PA Translational Breast Cancer Research Consortium (TBCRC) Soonmyung Paik, MD Richard C. Zellars, MD Mayo Clinic: Rochester, MN and Jacksonville, FL Debra L. Barton, RN, PhD, AOCN Walter C. Willett, MD, Dr.PH Made possible by Wilson Sporting Goods Fergus J. Couch, PhD Charis Eng, MD, PhD, FACP On behalf of CIMBA Hospital of Prato Coalition of Cancer Cooperative Groups Istituto Toscano Tumori James N. Ingle, MD Eastern Cooperative Oncology Group Prato, Italy The Play for P.I.N.K. Award Philadelphia, PA Angelo Di Leo, MD, PhD Charles L. Loprinzi, MD Robert L. Comis, MD Made possible by Pfizer, Inc. Hunter College Edith A. Perez, MD City University of New York The Play for P.I.N.K. Award New York, NY The breast Cancer Research Foundation® Mark E. Robson, MD The Sandra Taub Memorial Award Richard R. Love, MD, MS Ohio State University Fred Hutchinson Cancer Research Center Seattle, WA Ben Ho Park, MD, PhD Peggy L. Porter, MD On behalf of Southwest Oncology Group The Play for P.I.N.K. Award Kenneth Offit, MD, MPH The Sandra Taub Memorial Award Northwestern University Feinberg School of Medicine Chicago, IL Charles Clevenger, MD, PhD American Association for Cancer Research Vincent L. Cryns, MD The Housewares Charity Foundation Award William J. Gradishar, MD, FACP The Housewares Charity Foundation Award NYU School of Medicine New York, NY Silvia Formenti, MD The Coach Award Robert J. Schneider, PhD The Coach Award Ohio State University Columbus, OH Thomas Jefferson University Kimmel Cancer Center Philadelphia, PA Andrew A. Quong, PhD Electra D. Paskett, PhD The Play for P.I.N.K. Award Tufts University School of Medicine Boston, MA Queen’s University Kingston, Ontario, Canada Charlotte Kuperwasser, PhD Made possible by Saks Fifth Avenue Lois Shepherd, MDCM, FRCP(C) On behalf of NCIC Clinical Trials Group University of California Irvine, CA The Rockefeller University New York, NY Eva Y.-H. P. Lee, PhD Titia de Lange, PhD Made possible by Bloomingdale’s University of California Jonsson Comprehensive Cancer Center Los Angeles, CA Paul M. Nurse, PhD Patricia A. Ganz, MD Made possible by Estée Lauder Roswell Park Cancer Institute Buffalo, NY Christine B. Ambrosone, PhD Made possible by Prime Retail Royal Marsden Hospital and Institute of Cancer Research London, UK Mitch Dowsett, PhD, BSc The Elizabeth Hurley Award Mary Sehl, MD, PHD ASCO Cancer Foundation Annette L. Stanton, PhD Made possible by Ann Taylor Stores Corporation University of Kansas Medical Center Kansas City, KS University of Sydney Sydney, Australia Carol J. Fabian, MD Made possible by Ann Taylor Stores Corporation Janette Vardy, MD, FRACP, PhD ASCO Cancer Foundation University of Miami Miami, FL Tan A. Ince, MD, PhD Miller School of Medicine The Play for P.I.N.K. Award Marc E. Lippman, MD Miller School of Medicine The Play for P.I.N.K. Award University of California San Francisco, CA Geoffrey M. Wahl, PhD Laura J. Esserman, MD, MBA Sarah Lawrence College Bronxville, NY Shelley Hwang, MD, MPH On behalf of Cancer and Leukemia Group B Joan H. Marks, MS New York Breast Cancer Study Shaare Zedek Medical Center Jerusalem, Israel Ephrat Levy-Lahad, MD Sir Mortimer B. Davis – Jewish General Hospital/McGill University Montreal, Quebec, Canada Isabel Bedrosian, MD Mien-Chie Hung, PhD Kelly K. Hunt, MD, FACS On behalf of ACOSOG Shaomeng Wang, PhD John Mendelsohn, MD Stephen J. Weiss, MD Gordon B. Mills, MD, PhD Max S. Wicha, MD Lajos Pusztai, MD, D.Phil University of Newcastle, on behalf of Australian New Zealand Breast Cancer Trials Group, Australia W. Fraser Symmans, MD University of North Carolina Lineberger Comprehensive Cancer Center Chapel Hill, NC Salk Institute for Biological Studies La Jolla, CA University of Texas MD Anderson Cancer Center Houston, TX James M. Rae, PhD John Forbes, MB, BS Barbara A. Parker, MD Made possible by Macy’s Stephen D. Hursting, PhD, MPH Powel H. Brown, MD, PhD Joyce Slingerland, MD, PhD, FRCP(C) Braman Family Breast Cancer Institute Francisco J. Esteva, MD, PhD The Housewares Charity Foundation Award Zhen Fan, MD University of Michigan Ann Arbor, MI Sharon Giordano, MD, MPH NABCG/Breast International Group Daniel F. Hayes, MD NABCG/Breast International Group Ana Maria Gonzalez-Angulo, MD, MSc Made possible by Eisai Oncology On behalf of Southwest Oncology Group Sofia D. Merajver, MD, PhD Made possible by Delta Air Lines, Inc. Gabriel N. Hortobagyi, MD, FACP University of California Rebecca and John Moores Cancer Center Lori J. Pierce, MD San Diego, CA Made possible by ULTA Ian E. Smith, MD, FRCP, FRCPE The Elizabeth Hurley Award University of Texas Austin, TX Lisa A. Carey, MD Made possible by Saks Fifth Avenue University of Washington Seattle, WA Julie R. Gralow, MD On behalf of Southwest Oncology Group The Play for P.I.N.K. Award Mary-Claire King, PhD New York Breast Cancer Study Vall d’Hebron Institute of Oncology H. Shelton Earp, MD Barcelona, Spain Made possible by The Estée Lauder Field Joaquín Arribas, PhD Hyman B. Muss, MD José Baselga, MD Charles M. Perou, PhD Massachusetts General Hospital Made possible by Susan Hertog The Housewares Charity Foundation Award University of Oxford Oxford, UK Hope S. Rugo, MD Adrian Harris, MD, D.Phil The Housewares Charity Foundation Award Cancer Research UK Made possible by Delta Air Lines, Inc Laura J. van ‘t Veer, PhD University of Pennsylvania University of Cambridge Abramson Cancer Center Cambridge, UK Philadelphia, PA Sir Bruce A. J. Ponder, PhD, FRCP, FRS Lewis A. Chodosh, MD, PhD Cancer Research UK Susan M. Domchek, MD University of Chicago Medical Center Wilson H. Miller, MD, PhD Made possible by Hard Rock International American Association for Cancer Research Chicago, IL Mark I. Greene, MD, PhD, FRCP Latin American and Caribbean Society of Funmi I. Olopade, MB, BS, FACP The Play for P.I.N.K. Award Made possible by Macy’s Medical Oncology (SLACOM) Buenos Aires, Argentina Katherine L. Nathanson, MD Monika Burness, MD ASCO Cancer Foundation Eduardo Cazap, MD Robert H. Vonderheide, MD, D.Phil The Hirschhorn Award Made possible by Hard Rock International Stanford University School of Medicine University of Colorado Stanford, CA University of Pittsburgh Cancer Center Health Sciences Center Pittsburgh, PA Denver, CO Michael F. Clarke, MD Nancy E. Davidson, MD Kathryn B. Horwitz, PhD James M. Ford, MD NABCG/Breast International Group The Pink Promises Award in memory of Made possible by Genentech University of Edinburgh Patricia L. Hansen Edinburgh, Scotland Shannon Puhalla, MD Shaveta Vinayak, MD ASCO Cancer Foundation John Bartlett, PhD ASCO Cancer Foundation Breast International Group/NABCG University of Southern California Tel Aviv University Norris Comprehensive Cancer Center University of Illinois at Urbana-Champaign Los Angeles, CA Sackler School of Medicine Urbana, IL Tel Aviv, Israel Michael F. Press, MD, PhD Benita S. Katzenellenbogen, PhD Ilan Tsarfaty, PhD Made possible by Delta Air Lines, Inc. The Play for P.I.N.K. Award Van Andel Research Institute Grand Rapids, MI George F. Vande Woude, PhD Vanderbilt University School of Medicine Nashville, TN Carlos L. Arteaga, MD The von Mandl Family Award Washington University School of Medicine St. Louis, MO D. Craig Allred, MD Graham A. Colditz, MD, Dr.PH Matthew J. Ellis, MD, PhD On behalf of ACOSOG Weill Medical College of Cornell University New York, NY Andrew J. Dannenberg, MD Whitehead Institute for Biomedical Research Cambridge, MA Robert A. Weinberg, PhD Yale University School of Medicine New Haven, CT Lyndsay N. Harris, MD 9 Elizabeth Hurley Researchers Announced at Winfield House On October 18, at a reception hosted by U.S. Ambassador Louis Susman and Mrs. Marjorie Susman at Winfield House in London, The Breast Cancer Research Foundation honored Elizabeth Hurley for spreading the message globally about the urgency of funding research and also honored five BCRF-funded United Kingdom-based researchers for their stellar work. The first annual Elizabeth Hurley Researcher Award was bestowed upon the team of Drs. Ian Smith and Mitch Dowsett (Royal Marsden Hospital/Institute of Cancer Research, London). Also in attendance were Dr. Alan Ashworth (Institute of Cancer Research), Dr. Adrian Harris (Oxford University), and Sir Bruce Ponder (Cambridge University). 10 winter 2011 A dinner at Bar Boulud London, underwritten by LEVIEV, immediately followed to celebrate the great science being conducted in the UK with BCRF’s support. To date, BCRF has invested nearly $4 million in breast cancer research based in the UK, with nearly $1 million in 2010 alone. PHOTOS: Richard Lewis Photos (top to bottom): Dr. Mitch Dowsett, Elizabeth Hurley and Dr. Ian Smith; Elizabeth Hurley, David and Lisa Klein; Ambassador Louis Susman and Marjorie Susman The inaugural Hudson BCRF Golf Classic at Liberty National in NJ on July 12, raised over $525,000. After a sunny day of golf, guests enjoyed a cocktail reception with a special viewing of Michael Fux’s private luxury car collection. Celebrity golfers included sports stars Dan Marino, Jason Taylor, and Alonzo Mourning. Special thanks to Co-Chairs William Lauder and Paul Fireman, along with the support of major sponsors Hudson, The Paul & Phyllis Fireman Charitable Foundation, William Lauder, American Express, Cartier, Rolls-Royce, and The Michael Fux Foundation. Photos (top to bottom): Dan Marino, Peter Kim, William Lauder, Paul Fireman and Michael Fux; Ida Rothbaum, Mark Shirvan, Scott Tesser and Joe Rosen Westchester Luncheon For the fifth year, BCRF Advisory Board member Shelly Kivell, and Co-Chairs Ellen Brown, Debra Ezratty, Sheryl Kaye and Kim Meyers, organized a Luncheon at Fenway Golf Club in Scarsdale, NY, raising more than $180,000 from over 200 guests. BCRF Scientific Advisory Committee Chairman, Dr. Clifford Hudis, gave an overview of Breast Cancer: Progress and Promise that began with a historical perspective of biomedical research funding in the U.S. He made the point that the Foundation’s grants program is akin to the MacArthur Foundation’s “genius awards” in that BCRF’s Scientific Advisors seek out the most talented investigators with creative ideas and they are given the freedom to pursue their ideas with minimum bureaucracy. In Dr. Hudis’s words, “there is no other grants program like it” and BCRF-funded scientists have played a role in every important advance in breast cancer research since 1993. He told the audience that, while more targeted therapies for breast cancer and more precise measures of risk reduction are needed, it is important to remember that there has been steady progress. Breast cancer mortality rates have been falling since 1990, in a longer-living population that is more prone to being overweight. Many large-scale studies are underway to identify better and more effective treatments and improve quality of life for breast cancer survivors. Front row L-R: Debra Ezratty, Kim Meyers, Dr. Clifford Hudis, Evelyn Lauder and Myra Biblowit Back row L-R: Sheryl Kaye, Shelly Kivell, Ellen Brown The breast Cancer Research Foundation® PHOTOS: Michael Blanchard Hudson BCRF Golf Classic PHOTOS: Rob Rich Pink Promises On October 1, BCRF kicked off breast cancer awareness month with the inaugural Pink Promises benefit at Crest Hollow Country Club in Woodbury, NY. BCRF Advisory Board member Stephanie Ginsberg served as event Co-Chair along with her husband Ian, President of C.O. Bigelow. Over 950 guests attended this sold-out event, which featured unique auction items, raffle prizes, and fabulous cocktails donated by Mike’s Hard Lemonade. The ballroom was adorned with sequin overlays and diamond encrusted centerpieces, in keeping with the evening’s Denim and Diamonds theme. The Mistress of Ceremonies, LXTV anchor Sara Gore, introduced Stephanie. Stephanie spoke lovingly about her sister Betsy, who has been battling triple negative breast cancer for the past five years and is the motivation behind the Ginsbergs’ personal commitment to Pink Promises—“to raise significant funds…so we may all see a cure in our lifetime.” Then, Honorary Chairman Evelyn Lauder expressed her enthusiasm and utmost gratitude for the remarkable turnout from the Long Island community. BCRF grantee and keynote speaker Dr. Robert Benezra of Memorial-Sloan Kettering Cancer Center, shared a few words regarding his research on breast tumor growth, angiogenesis, and metastasis that is made possible through BCRF funding. The excitement swelled when popular appraiser and host of PBS’s History Detectives, Elyse Luray, conducted the live auction, and pop singer Matisse ended the night on a high note with her live performance. Pink Promises was a huge success, raising over $850,000, demonstrating Long Island’s strong commitment to finding a cure. The event was made possible by premier underwriters C.O. Bigelow, The Buller Family Foundation and Marjam Supply Company, along with lead underwriters BNY Mellon and The Estée Lauder Companies Inc. Special thanks to sponsors Americana Manhasset, Duffy & Duffy, Sharon and Rich Greenstein, the Jaffee Family, Perfumania, and Tanger Outlet Centers. Sincere thanks to the wonderful Host Committee for their hours of dedication. Photos (top to bottom): Rita & Frank Castagna and Evelyn Lauder; Wendy, Alec, Ian, Stephanie and Reed Ginsberg; Sarah & Mark Buller and Cherie & James Buller PHOTO: Julie Skarratt Letter from our President This year, I am proud to report that BCRF is awarding grants totaling $33 million to 172 researchers from 12 countries around the world. Those are big dollars and you may ask, what is that investment yielding in 2011? What are the most promising opportunities where our funding can make a material difference in the lives of women, both in surviving the disease and preventing it altogether? BCRF’s grantmaking is organized around two main themes: Finding the Cause—whether that means inherited risk factors, environmental factors, or even when good cells go bad; and Finding the Cure—endeavors such as the development of vaccines; the ability to assess risk for breast cancer development, and also for recurrence; the creation of new targeted therapies; and empowering breast cancer survivors to lead the healthiest possible lives on their road to complete recovery. Over the past 16-plus years, BCRF’s grantees have been responsible for some of the most important breakthroughs to date in breast cancer research. They are truly the “who’s who” of breast cancer research. Whenever a new advance is reported, you will see a BCRF grantee’s name. Your generous support is what has been driving and leveraging incredible scientific progress and hope. Thank you for enabling BCRF’s army of brilliant minds to take on the resolution of breast cancer through multi-faceted approaches. We hope that we can continue to count on your support as we push forward towards our goal of eradicating breast cancer in our lifetime. Sincerely, Myra J. Biblowit 11 12 winter 2011 2010: Play for P.I.N.K. Reaches New Heights On October 27, Play for P.I.N.K.’s (PFP) Board proudly presented a record-breaking $3.25 million check to Evelyn Lauder and The Breast Cancer Research Foundation, bringing its cumulative contribution to $22 million! Representatives from Bloomberg and The Estée Lauder Companies joined the PFP board for this special moment. Honored guests included many of the PFPfunded researchers; Dr. Larry Norton, BCRF Scientific Director and Chairman of the BCRF Executive Board of Scientific Advisors; and Dr. Clifford Hudis, Chairman of the BCRF Scientific Advisory Committee. This amazing donation was made possible by an unparalleled number of participants with an increase in both clubs and events. More than 220 clubs in over twenty-four states got behind PFP this year. This phenomenal growth would not be possible without our dedicated board, chairwomen, participants, and of course our generous sponsors. Bloomberg, our title sponsor, underwrites all of the expenses of PFP, enabling 100% of the proceeds to be donated to BCRF. The Estée Lauder Companies and Wilson Sporting Goods support PFP through their contribution of gifts and merchandise. We thank you for your tremendous P.I.N.K. support and look forward to another successful year in 2011! Think P.I.N.K. Be in the know. Visit www.playforpink.org or call me at 646-497-2605 to find out about ongoing happenings, how to get involved, or to make a donation. Sincerely, Stephanie Hamburger Director, Play for P.I.N.K. Delta “Taking Flight for the Fight” Led by Delta CEO Richard Anderson on September 30, 100 Delta employees who are breast cancer survivors, flew in the new pink Boeing 767 from Atlanta to Detroit to Minneapolis to inaugurate Delta’s annual breast cancer program to support BCRF. In addition to donating proceeds from onboard “pink” sales, Delta had a virtual lemonade stand on Facebook and donated SkyMiles to BCRF when customers downloaded the Delta iPhone application. In its sixth year, Delta and its dedicated employees have helped raise over $2.5 million cumulatively for BCRF and are currently supporting four research projects around the world. The breast Cancer Research Foundation® Ann Taylor and LOFT Continue to Raise the Philanthropic Bar Ann Taylor Stores Corporation, under the leadership of CEO Kay Krill, raised an unprecedented $2.6 million for BCRF through their ANN Cares® Card and LOFT Cares® Card programs and products this October. This year’s record-breaking contribution represents an increase of more than 120% over the previous year and a cumulative donation of more than $6.4 million to BCRF. In 2010-11, Ann Taylor Stores Corporation is supporting four research projects: Dr. Kathy Miller from the Indiana University School of Medicine, Dr. Annette Stanton from UCLA, Dr. Carol Fabian from the University of Kansas, and Dr. Dawn Hershman from Columbia University. The 2010 donation will fund ten BCRF research projects in 2011-2012. 13 Photo: Kara Ross, Myra Biblowit, Deborah Cavanagh, Robin Renzi and Gary Muto Bloomingdale’s Pink Campaign Bloomingdale’s Pink Campaign included a variety of products from The Big Pink Umbrella (designed by BCRF Advisory Board member Marisa Acocella Marchetto) to The Little Pink Card, the “Give Pink, Get More” program, and the famous Little Pink Boutique. The 2010 Pink Campaign raised a phenomenal $1.3 million for BCRF, bringing the retailer’s total donation to over $3 million. Currently, Bloomingdale’s is supporting the research of Dr. Titia de Lange of The Rockefeller University in New York City and Dr. Joan Brugge of Harvard Medical School in Boston. Photos: Evelyn Lauder and Elizabeth Hurley pose with bloggers;Howard Kreitzman,Francine Klein and Elizabeth Hurley The Estée Lauder Companies’ 2010 Breast Cancer Awareness Campaign Every October, The Estée Lauder Companies unfolds its Breast Cancer Awareness (BCA) campaign. The company and employees sponsor a series of awareness and fundraising programs with the goal of informing millions of people each year about the importance of breast health and early detection and to raise funds for BCRF. A cornerstone of the BCA campaign is the Estée Lauder Companies’ Global Landmark Illumination Initiative. In its 11th Anniversary, more than 200 famous buildings, monuments, and landmarks were illuminated in glowing pink lights to stand as international symbols of hope to empower and enlighten millions of women everywhere. The initiative launched with 38 global landmarks lit pink within 24 hours, achieving a new Guinness World Record, “Most Landmarks Illuminated for a Cause in 24 Hours.” Photos: The Estée Lauder Companies’ Sale-A-Bration volunteers; The Estée Lauder brand’s check presentation to Evelyn Lauder and BCRF; William Lauder and Rich Lehrer at Estée Lauder golf outing PHOTOS: Wire Image.com On September 29, many influential bloggers attended the kick-off for Bloomingdale’s Pink Campaign and The Estée Lauder Companies’ 2010 Breast Cancer Awareness Campaign at Bloomingdale’s flagship 59th Street store in NYC. Evelyn Lauder and Estée Lauder spokesmodel Elizabeth Hurley addressed an eager crowd, then signed specially designed Estée Lauder Pink Ribbon products benefiting BCRF. community fundraisers Cross Country for the Cure: Fairbury, IL The Prairie Central Cross Country team held a “Cross Country for the Cure” run on October 26. The team started on Fairbury’s main street and ran around town until exhausted. Each member of the team ran for at least 80 minutes, and some ran for a full 120 minutes! The team members raised funds from the community, either as a flat donation or pledging a dollar amount per minute ran. The team raised over $2,600 and are excited to turn this into an annual event. 14 winter 2011 F Stop Breast Cancer: www.fstopbreastcancer.com Lydia Shannon is a 23-year-old photographer. After finding out she has an 84% chance of getting breast cancer (based on genetic testing), she wanted to do something to make a difference. She told friends and family that if she raised $10,000, she would shave her head and donate her hair. She created an online photography auction and raffle called, F Stop Breast Cancer, which raised over $12,000; hence, her current baldness. Camp Phoenix: Kabul, Afghanistan In a little over 40 days, Shamika Mitchell of Delta Detachment (82nd Financial Management Company in Fort Bragg, North Carolina), PFC Michelle Redner and SPC Erin Quinn of Bravo Company (186th BSB) planned a race in Camp Phoenix, Afghanistan. On October 23, 6:30 AM, more than 300 people came out to run four miles or walk two miles. They raised $3,000. Bunco For Breast Cancer: Woodstock, IL On October 17, the Crystal Lake Inn was buzzing with organizers and volunteers as they set-up for Woodstock’s 6th Annual Bunco For Breast Cancer event. The first of 600 guests arrived early and by 1pm, 50 huge baskets had been raffled, the room was filled to capacity and the Bunco started. It didn’t take long before $65,000 was raised! The Woodstock group – founded in 2005 by Susan Martino and her daughters, Tracy Noe and Laura Littner – has become the biggest and most successful group in the history of Bunco For Breast Cancer. Susan and her daughters are all breast cancer survivors and share an inspiring determination to support the Foundation’s mission. The event has cumulatively generated over $260,000 for BCRF. Photo: Laura Martino Littner, Tracy Martino Noe, Susan Martino, Walter Martino and Michelle Martino Mitchell BCRF Leaders Council Gail Hilson, Chairman Roberta M. Amon Jessie Araskog Muffie Potter Aston Anne H. Bass Candice Bergen Magda Bleier Melinda Blinken Katherine Bryan Susan Payson Burke Catherine Cahill Wendy Carduner Patty Cisneros Norma Dana Beth Rudin DeWoody Barbaralee Diamonstein-Spielvogel Robin Chandler Duke HRH Princess Firyal Anne Eisenhower Flöttl Marjorie Reed Gordon Lorna Hyde Graev Jamee Gregory Audrey Gruss Joanne de Guardiola Candy Hamm Mai Hallingby Harrison Dina Merrill Hartley Gale Hayman Veronica Hearst Marlene Hess Karen M. Karp Mariana Kaufman Kitty Kempner Eleanora Kennedy Coco Kopelman Jo Carole Lauder Karen Lauder Karen LeFrak Wendy Vanderbilt Lehman Memrie M. Lewis The breast Cancer Research Foundation® Nicole Limbocker Carol Mack Hillie Mahoney Ketty Maisonrouge Grace T. Meigher Liz Mezzacappa Muffy Miller Nancy Missett Gigi Mortimer Deborah Norville Libby Pataki Pat Patterson Jean H. Pearman Toni Peebler Carroll Petrie Pauline Pitt Patricia Quick Annette de la Renta Patricia Rosenwald Hilary Geary Ross June Schorr Christine Hearst Schwarzman Jeanne Sorensen Siegel Nancy Silverman Anne Sitrick Daisy Soros Louise M. Sunshine Felicia Taylor Joan H. Tisch Adrienne Vittadini Barbara Walters Patricia G. Warner Thorunn Wathne Harriet Weintraub Saundra Whitney Vivien Wyser-Pratte Paula Zahn Thank You BCRF Advisory Board Nestle Waters doubled its donation and presented a $500,000 check to BCRF. Pictured: Robbie Franklin; Kim Jeffery, President and CEO, Nestle Waters North America; Myra Biblowit On September 13, Kmart and breast cancer survivor Jaclyn Smith (pictured with Mark Snyder, Chief Marketing Officer, Kmart) celebrated the 25th Anniversary of their design collaboration. $1 of any purchase from the limited-edition home and fashion collection was donated to BCRF. Thanks to Jerry Kohl and his wife Terri, Brighton Collectibles is contributing 100% of the proceeds from a special pink ribbon charm to BCRF. Enclosed with the charm is a $20 check to BCRF. Customers mail the check to BCRF. This novel campaign has been widely successful and raised nearly $80,000 to date. On October 25, Reed Krakoff hosted an evening at his new NYC store to celebrate BCRF, and honored the Foundation with a gift of $25,000. Pictured: Co-hosts Gigi Mortimer, Tory Burch, Reed Krakoff, Evelyn Lauder and Perri Peltz. Federico Lagrange of Northland (L) presented a $30,000 check to Jaclyn Lee of BCRF (R) at the BJ’s Wholesale Club in Miami. The donation was made possible through Northland’s Drink to Pink program, which BJ’s enthusiastically supported in their May 2010 promotion. On July 12, Key Food organized a golf outing to raise $50,000 for BCRF. Pictured is Dean Janeway, Chief Executive Officer of Key Food Stores. Arlene Adler Roberta M. Amon Melinda Blinken Mary Bryant Susan Payson Burke Darlene Daggett Rena Rowan Damone Elisha Daniels Ute Dugan, MD, PhD Suzanne Elson Anne Eisenhower Flöttl Stephanie Ginsberg Amy P. Goldman, PhD Barbara Goldsmith Roslyn Goldstein Marjorie Reed Gordon Lorna Hyde Graev Betsy S. Green Bette-Ann Gwathmey Lori Hall Susan Hertog Ronnie Heyman Gail Hilson Susan B. Hirschhorn Jane Hertzmark Hudis Robin J. Kemper Rochelle Kivell Sandra Krakoff Elyse Lacher Maralyn Lakin Laura Lassman Ellen Levine Marisa Acocella Marchetto Ellen Odoner, Esq. Mary Alice Pappas Winifred Gorlin Phillips Jane Pontarelli Patricia Quick Katharine Rayner Lynda Resnick Wendi Rose Patricia Rosenwald Valerie Salembier Suzanne Santry Judith P. Schlager Muriel Siebert Anne Sitrick Joanne Smith Erana Stennett Arlene Taub Linda Waintrup Cathy Weinroth Harriet Weintraub Candace King Weir Nina Wexler Sara Wolfensohn Jacki Zehner Rhonda S. Zinner 15 The Breast Cancer Research Foundation 60 East 56th Street, 8th Floor New York, New York 10022 NON-PROFIT US POSTAGE PAID ADDRESS SERVICE REQUESTED NEW YORK, NY PRINTED ON RECYCLED PAPER PERMIT NO. 2377 BCRF Board of Directors Evelyn H. Lauder, Founder and Chairman Myra J. Biblowit, President Jeanette S. Wagner, Vice President Deborah Krulewitch, Secretary and Treasurer Carolee Friedlander Kinga Lampert Cynthia Lufkin Carlyn S. McCaffrey, Esq. Teruca Rullán Josie Robertson, in memoriam To Contact BCRF: 646.497.2600 / 866 FINDACURE bcrf@bcrfcure.org www.bcrfcure.org Executive Board of Scientific Advisors Scientific Advisory Committee Chairman and Scientific Director Larry Norton, MD Memorial Sloan-Kettering Cancer Center Chairman Clifford Hudis, MD Memorial Sloan-Kettering Cancer Center Members Nancy E. Davidson, MD University of Pittsburgh Cancer Institute Members Patricia A. Ganz, MD Jonsson Comprehensive Cancer Center University of California, Los Angeles PHOTOS: Rob Rich winter 2011 16 Peter Greenwald, MD, Dr.PH National Cancer Institute National Institutes of Health Gabriel N. Hortobagyi, MD University of Texas MD Anderson Cancer Center 2011 PINK Calendar FEBRUARY The Hot Pink Luncheon & Symposium Monday, February 7 The Breakers, Palm Beach, FL MARCH Challenge of the Americas Saturday, March 12 International Polo Club, Wellington, FL Judy E. Garber, MD, MPH Dana-Farber Cancer Institute Harvard Medical School Lajos Pusztai, MD, D.Phil University of Texas MD Anderson Cancer Center Vered Stearns, MD Johns Hopkins University School of Medicine The Boston Hot Pink Party Tuesday, May 17 Museum of Fine Arts, Boston JULY BCRF Golf Classic Monday, July 18 Liberty National Golf Course, Jersey City, NJ Boston Hot Pink Party Kick-off Event Wednesday, March 16 David Yurman Copley Place, Boston AUGUST Estée Lauder’s “Play for Pink” Golf & Tennis Classic Monday, August 15 Old Westbury Country Club, Old Westbury, NY APRIL The Hot Pink Party with Sir Elton John Thursday, April 14 The Waldorf=Astoria, NYC OCTOBER Pink Promises Luncheon and Symposium Wednesday, October 12 Long Island, NY MAY Chappaqua’s A Cure in Our Lifetime Breakfast Friday, May 13 Trump National Golf Club, Briarcliff Manor, NY Symposium and Annual Awards Luncheon Wednesday, October 26 The Waldorf=Astoria, NYC The breast Cancer Research Foundation®