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This newsletter is brought to you by the BCMP Trainee Committee
Our Mission Statement: The Biological Chemistry and Molecular Pharmacology Trainee Committee is
responsible for addressing the needs of the graduate students and postdoctoral fellows in the department.
This committee is charged with identifying ways to create a sense of community for students and fellows
and to increase interactions between trainees and the faculty. The Committee meets regularly with faculty
and departmental administration to suggest and implement improvements for students and fellows. If you
have any concerns or suggestions please contact a committee member.
New members are welcome!
Current Members: Ravi Amunugama (Walter), Luke Chao (Harrison), Jyoti Dev (Chou), Daniela Fera (Harrison),
Thomas Graham (Co-Chair, Loparo/Walter), Dane Hazelbaker (Buratowski), Alfredo Hernandez (Richardson), Elissa
Hobert (Clardy), James Kath (Co-Chair, Loparo), Krish Karunatilaka (Hogle), Phong Lee (Harrison), Bo Liang (Harrison),
Emily Low (Walter), Rafael Luna (Wagner), David Migl (Harrison), Mukesh Sharma (Chou), Ethan Van Arnam (Clardy),
Kyle Vrtis (Walter) , Jason Heustis (curriculum fellow), Mabel Duyao, Laurance Hem & Kristen Parker (Administration)
https://bcmp.med.harvard.edu/trainee-committee
BCMP Quarterly
A Publication of HMS | BCMP
Editor in Chief James Kath
Boston, MA
Compiled by James Kath, Phong Lee, and Thomas Graham
https://bcmp.med.harvard.edu/
(C) Copyright 2014 by the President and Fellows of Harvard College
Quarterly
Summer 2015 Issue
Faculty Interview: Professor Andrew Kruse
Emily Low and Ethan Van Arnam
We sat down with Andrew Kruse, BCMP’s newest
faculty member, to chat about his road here and
where his laboratory is heading.
Where did you get your start in science?
I grew up in the suburbs of Minneapolis, and I went
to college at the University of Minnesota, mainly
because it was close to home and it was cheap. I was
interested in quantitative areas of biology, and I
joined a structural biology lab during my sophomore year to get hands-on experience in research.
I’ve been doing one form or another of structural
biology ever since.
For graduate school you headed to Stanford
to work on G protein-coupled receptors
(GPCRs). What drew you to that work?
At the time when I was first applying to grad school,
I knew that I wanted to do something involving
structure and function of proteins important in
human health and disease. GPCRs are critical reguAndrew in his temporary office - a dark room. lators of most aspects of human physiology and
they’re targets for 30% of marketed therapeutic
drugs. And protein conformational change signaling mechanisms, to me, are just really interesting:
these receptors are molecular machines and I just think that’s kind of neat.
While you were in grad school your advisor, Brian Kobilka, won the Nobel Prize in chemistry. How did you learn the news on the day of the announcement?
I actually lived right next to Brian while I was in grad school – a long story. I rented a little cottage
behind the house of Brian’s neighbor. On the day he won the prize, I got up and there were all these
news vans lining the street. I wondered what was going on – I didn’t know at the time – then I biked to
work, and when I got to lab, everything was crazy.
What went into your decision to apply to faculty jobs directly out of grad school?
It was kind of a combination of things. I didn’t feel like I needed to learn an entirely new field, because
I knew I wanted to do receptor structural biology. Also, I felt like I was ready: I had the background that
I needed, and I knew that the science that I wanted to do was an extension of work I had been doing as
a grad student. With my thesis committee supporting my decision, it seemed like everything fit
together.
Interview continues inside
Issue#1 2015
Department of Biological Chemistry and Molecular Pharmacology
Welcome to BCMP!
Kruse interview, continued
Are you at the bench a lot?
I’ve been doing a lot of grant writing this last month, but in general, I try to be there about half the time.
Are you eager to let the bench work go?
No, actually. With all the grant writing, I appreciate bench work more. Initially, it’s nice to take a little
break from running gels and doing some of the more mundane things, but bench work is quickly becoming a more relaxing thing than writing all the time—writing gets to be a bit tedious, fast!
Are you liking Boston?
Yeah! I mean, it’s a big transition from California, and the weather especially this past winter was pretty
intense. My parents are in California, so I still get a chance to go back for the holidays.
Do people in your lab call you Andy?
I think people mostly call me Andrew. I don’t really care what they call me! As long as I know they’re
talking to me, it’s fine.
What’s the story behind the paperweight of a GPCR structure
sitting on your desk?
This is the active β2 adrenergic receptor in complex with the Gs heterotrimer. This is probably the most important structure I was personally
involved with during my time in the Kobilka Lab. A postdoc in the lab
[Søren Rasmussen] led the project, and I worked on the X-ray data
collection, and did the structure refinement together with Bill Weis.
When we were solving this structure, we were flying to Chicago basically
once a week for data collection. We knew we had the real thing, but we
needed to get a complete data set and we wanted to get higher resolution
data. It was a very intense time – to get the structure solved, get everything refined, and get it written up and published as quickly as possible.
At the time we thought someone else might have had a similar structure,
though that turns out not to have been true.
Puzzle: Who is this?
Can anyone tell us the names of
these mystery professors whose
portraits are on the second floor
of C-building?
Answers will be featured in the
next BCMP newsletter!
2
Buratowski lab
Susana Rodriguez-Navarro joins as a visting professor on sabbatical from the Centro de Investigacion Principe Felipe in Valencia, Spain.
Hyun Jin Bae, postdoc, from the Catholic University in Seoul, South Korea.
Chou lab
Chan Cao, visiting PhD student, from Nankai University in China
Coen lab
Lei Feng, postdoc, from the Institute of Microbiology at the Chinese Academy of Sciences
Gang Li, postdoc, from LSU Health Services Center Shreveport
Purba Mukherjee, postdoc, from University at Albany, SUNY
Daley lab
Deepak Jha, postdoctoral fellow, from UNC Chapel Hill
Yu-Chung “Harry” Huang, visiting scientist, from National Yang-Ming University (MD) in Taiwan
Areum Han, postdoc, from UCLA
Melissa Kinney, postdoc, from Georgia Tech and Emory University
Vanessa Lundin, postdoc, from Karolinska Institutet in Sweden
Lara Wahlster, postdoc, from Heidelberg University in Germany
Ryohichi Sugimura, postdoc, from Osaka University (Japan) and the Stowers Institute
Springer lab
Bill Ma, postdoc, from University of Wisconsin-Madison
Wagner lab
Sandeep Chhabra, Research Fellow, from Monash University in Australia
Walter lab
Ben Stinson, postdoc, from MIT
Wong lab
Clinton Hansen, postdoc, a graduate of the Harvard Biophysics program from the van Oudenaarden lab
Serkan Cabi, postdoc, from MIT
Zhao lab
Yunneng Tang, postdoc, from the Shanghai Institute for Biochemistry and Cell Biology at the Chinese
Academy of Sciences
April Watt from the Nolan lab at the University of Oregon joined as a star technician and mouse expert.
11
Issue#1 2015
Department of Biological Chemistry and Molecular Pharmacology
Lab Highlights
Trainee Spotlight
The Daley lab had their annual retreat February 3-5 at the
Oliver Lodge resort in Meredith, NH (right). Science was
discussed and absolutely no fun was had.
Yuan Tian (Springer lab) received a Komen postdoctoral
fellowship that will support his work studying bone morphogenetic protein procomplexes and their roles in breast cancer stem
cell biology.
At the 56th American Society of Hematology meeting in San
Francisco last December, Tim Springer received the Henry M.
Stratton Medal for his contributions in hematology (below).
By Emily Low
Describe your science for
us.
Why did you become a scientist? What’s the coolest thing
about being a scientist?
In the Chou lab, I study membrane protein structure using
NMR spectroscopy. I recently
determined the structure of a
bacterial transmembrane
reductase. This new structure
led us to propose a new mechanism in bacterial thiol-redox
regulation. It was the last
missing piece in this big pathway and I’m pretty excited to
get the story out there.
I love having an idea, testing it,
and then looking back over the
results and seeing that my idea
was correct (or that it was wrong,
but that I’ve learned something
else). This can happen in a day, or
over the course of years—either
way, I find it very satisfying. Also,
I’m happiest at the bench. I love
executing a well-planned experiment. Oh, and magnets.
REALLY big magnets. So cool.
Describe your science for
us.
Walter lab postdoc Kyle Vrtis was awarded- an
American Cancer Society postdoctoral fellowship.
I work on the biochemistry of
cell division, and specifically, I
work on chromosome biology.
I’m interested in how cohesin
knows to go to centromeres, and
so I’d like to understand the
proteins that participate in this
localization pathway. We made
a nice advance when we were
able to determine the structure
of a complex that actually loads
cohesin onto chromosomes, and
that told us a lot about how the
regulation works.
Lauren Thorpe in the Zhao lab defended her
thesis on the role of the PI3K regulatory subunits
in cancer using mouse models. Congratulations,
Dr. Thorpe!
Melissa Leger-Abraham, a postdoc in the
Wagner lab, was promoted to Instructor.
For those of you who read the last issue’s Trainee
Spotlight of Jacob Sargent (Loparo lab), he won
his Belt Buckle Run competition. The final challenge
was to continuously run 20 minutes, every hour, for
as long as possible. As the Grand Champion, Jacob
took the prize (right) by running roughly 80 miles
over 48 hours.
10
Stephen Hinshaw,
Harrison Lab
Why did you become a
scientist? What’s the coolest thing about being a
scientist?
Since I was little, I’ve enjoyed
solving puzzles. The coolest
thing about science in general is
Jessica Williamson, Ph.D.,
Chou lab
If you could ask any scientist,
alive or dead, one single question, who would you ask and
what would the question be?
I’d rather ask every single scientist,
“Can you explain your work to
anyone, any age, any background, so
that they could understand it?” I
think demystifying current science
in the general population could go a
long way toward supporting scientific growth in society. Also, we have
Neil deGrasse Tyson and Bill
Nye…but where is our supercool
woman of science superstar? Let’s
get our diverse voices out there!
what those puzzles end up to be. I
enjoy, I think like all of us, making
discoveries.
If you weren’t a scientist, what
would you be?
I like baseball. I don’t think I’m
good enough to be a baseball player—although I played when I was
young—but maybe I’d be a baseball
writer, or maybe an announcer.
Announcers get to travel with the
team, and they have to know all of
these facts about all these old games
that happened…so that’d be fun.
3
Issue#1 2015
Department of Biological Chemistry and Molecular Pharmacology
Word on the
Street
By Elissa Hobert
and Jess Williamson
Q: If you were not a scientist
in BCMP, what would your
job be?
Farewells
Buratowski lab postdoc Sebastian Marquardt is now an Assistant Professor at the University of Copenhagen.
Jessica Williamson (Chou lab) has joined Beryllium (Bedford, MA) as a research scientist.
Tanxing Cui (Chou lab) is now Senior Development Scientist at Scientific Protein Laboratories.
Degree in hand, Jacob Sargent (Loparo lab) is returning to the field of education.
Adem Koksal (Springer lab) joned MedImmune in Gaithersburg, MD as a research scientist.
Pontus Nordenfelt (Springer lab) is establishing his lab at Lund University in Sweden.
Jianghai Zhu (Springer lab) is now a senior scientist at the Advanced Biomedical Computing Center at Frederick
National Laboratory for Cancer Research
“Brew master”
James Kath, Loparo Lab “Novelist”
Seung-Joo Lee,
Richardson lab
“Writer for WB TV shows”
Joe Loparo
“Baker”
Jyoti Dev, Chou lab
After earning her PhD, Shuai Li (Wagner lab) joined IBM in Armonk, NY.
Wagner lab visiting postdoc Xinjing (Sid) Jia returned to University of Queensland in Australia.
The Zhao lab said goodbye to technician Mayuko Segawa.
Milestones
Samir Sharma (right), the son of Mukesh Sharma (Chou
lab), arrived on March 13.
Peng Du (Gregory lab) and his wife Lijuan announced the
birth of their son, Andy Du, on November 24.
“Writer” Purba
Mukherjee, Coen lab
“Dive master”
“Full-time bird watcher”
Ethan van Arnam, Clardy lab Emily Mevers
Clardy Lab
“Gas station attendant”
Kevin McCarthy,
Harrison lab
On December 14, Lizz Thrall and her wife Giselle welcomed
their son, Henry “Hank” Worthy Schuetz-Thrall, shown
below in an onesie designed by the Loparo lab at their baby
shower.
Julien Duxin (Walter lab) and his wife Fernanda
announced the birth of his son Felix on November 1.
“Wall street
stock broker”
Donald Raymond,
Harrison Lab
4
Shunsuke Imai (Wagner lab) and his wife Chifumi
were joined by their daughter Reika on December
18.
“Jedi Knight”
Thomas Graham,
Loparo/Walter labs
“Singer”
Yujin Chun
Buratowski lab
“Chemist or engineer”
Andrew Kruse
Mahmoud Nasr (Wagner lab), his wife Marwa
Sabe and daughter Yasmine welcomed another
daughter, Amina on December 27.
9
Issue#1 2015
Department of Biological Chemistry and Molecular Pharmacology
Career resources
Wagner lab, cont.
The majority of biomedical PhDs pursue non-academic or non-tenure track science-related careers.*
Harvard and the Greater Boston area offers a variety of resources to explore your options.
Akabayov SR, Akabayov B, Wagner G. Human translation initiation factor eIF4G1 possesses a low-affini-ty ATP binding site facing the ATP-binding cleft of
eIF4A in the eIF4G/eIF4A complex. Biochemistry
(2014) 21, 6422-6425.
Elter S, Raschle T, Arens S, Viegas A, Gelev V,
Etzkorn M, Wagner G. The use of amphipols for NMR
structural characterization of 7-TM proteins. J
Membr Biol (2014) 247, 957-964.
Ivanov P, O’Day E, Emara MM, Wagner G, Lieberman J, Anderson P. G-quadruplex structures contribute to the neuroprotective effects of angiogenin-induced tRNA fragments. Proc Natl Acad Sci USA
(2014) 111, 18201-18206.
Kaptein R, Wagner G. NMR studies of membrane
proteins. J Biomol NMR (2015) 61, 181-184.
Walter lab
Zhang J, Dewar JM, Budzowska M, Motnenko A,
Cohn MA, Walter JC. DNA interstrand cross-link
repair requires replication-fork convergence. Nat
Struct Mol Biol (2015) 22, 242-247.
Wong lab
Koussa MA, Halvorsen K, Ward A, Wong WP. DNA
Nanoswitches: A quantitative platform for gel-based
biomolecular interaction analysis. Nat Methods
(2015), 12, 123-126.
Zhao lab
Thorpe LM, Yuzugullu H, Zhao JJ. PI3K in cancer:
divergent roles of isoforms, modes of activation and
therapeutic targeting. Nat Rev Cancer (2015) 15: 7-2.
Career guidance for academic and non-academic jobs
Office of Career Services (for students)
http://www.ocs.fas.harvard.edu/students.htm
Events: Info events, consultation for resume writing and interviews, connection to Harvard alumni networks
Trapped!
A harrowing true story
of terror and survival!
Seven members of the Clardy lab became
stranded in one of the C building elevators on
April 21st. They were leaving the lab to get
ice cream in the middle of a work day. The
stranded individuals were able to communicate with the outside world through a small
crack between the elevator doors and they
remained in positive spirits while facilities
maintenance staff worked to free them.
Professor Jon Clardy oversaw the "rescue"
effort and offered to feed the stranded individuals leftover Happy Hour candy through the
crack in the door, though this offer was
declined. The maintenance staff successfully
dislodged the jammed doors and the lab
members were freed after approximately 20
minutes of captivity. The elevator was
returned to service the next day and has
functioned without incident since.
Office of Postdoctoral Fellows
http://postdoc.hms.harvard.edu/
Events: Workshops, career panels, office hours for consultation
Harvard clubs (see links for listserv access)
Harvard Biotech Club
http://thebiotechclub.org
Events: Career fair (9/5/15), journal club every other week
Harvard Graduate Business Club
http://harvardgraduatebusinessclub.com/
Events: Mini-MBA program (every summer), monthly business journal club, finance workshops, entrepreneurship and career development events
Harvard Consulting Club
http://www.harvardgraduateconsultingclub.com/
Events: Consulting Career Fair (06/24/2015), MIT vs. Harvard Case Competition (8/17/15), weekly case/interview practice sessions, consulting workshops, panel discussion with consultants, networking events,
information sessions with representatives from different firms
GSAS Science Policy Path
http://projects.iq.harvard.edu/sciencepolicy/home
Events: Faculty chats, yearly DC trip in the spring (preference toward graduate students)
DMS PATHS
https://www.hms.harvard.edu/dms/resources/paths.html
Individual clubs available to students, focusing on non-tenure track careers: Biotechnology, Consulting, Education, Law, Policy and Non-Profit, Science Writing; resources potentially available to start new clubs
Boston area organizations
Massachusetts Biotechnology Council
http://www.massbio.org/
Some events and resources may require membership, which may be available to those at HMS/hospitals
Massachusetts Association for Women in Science
http://mass-awis.org/
8
Biotech Tuesday
https://biotechtuesday.com/
* http://ascb.org/where-will-a-biology-phd-take-you/
5
BCMP In Press
Issue#1 2015
Chou lab
Sounier R, Bellot G, Chou JJ. Mapping conformational heterogeneity of mitochondrial nucleotidetransporter in uninhibited states. Angew Chem Int
Ed Engl (2015) 54, 2436-2441.
Dev J, Brüschweiler S, Ouyang B, Chou JJ. Transverse relaxation dispersion of the p7 membrane
channel from hepatitis C virus reveals conformational breathing. J Biomol NMR (2015) 61, 369-378.
Kalita MM, Griffin S, Chou JJ, Fischer WB. Genotype-specific differences in structural features of hepatitis C virus (HCV) p7 membrane protein. Biochim
Biophys Acta (2015) 1848 1383-1392.
Coen lab
Bender BJ, Coen DM, Strang, BL. Dynamic and
nucleolin-dependent localization of human cytomegalovirus UL84 to the periphery of viral replication
compartments and nucleoli. J Virol (2014) 88,
11738-11747.
Chan H, Beardsley GP, Coen DM. Mechanism of
ganciclovir-induced chain termination revealed by
resistant viral polymerase mutants with reduced exonuclease activity. Proc Natl Acad Sci USA (2014) 111,
17462-17467.
Sharma M, Bender BJ, Kamil JP, Lye MF, Pesola JM,
Reim NI, Hogle JM, Coen DM. Human cytomegalovirus UL97 phosphorylates the viral nuclear egress
complex. J Virol (2015) 89, 523-534.
Daley lab
Cahan P, Morris SA, Collins JJ, Daley GQ. Defining
cellular identity through network biology. Cell Cycle
(2014) 13, 3313-3314.
Unternaehrer JJ, Zhao R, Kim K, Cesana M, Powers
JT, Ratanasirintrawoot S, Onder T, Shibue T, Weinberg RA, Daley GQ. The epithelial-mesenchymal
transition factor Snail paradoxically enhances reprogramming. Stem Cell Reports (2014) 11, 691-698.
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Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW,
Daley GQ. A non-transcriptional role for Oct4 in
the regulation of mitotic entry. Proc Natl Acad Sci
U S A (2014) 111, 15768-15773.
Schlaeger TM, Daheron L, Brickler TR, Entwisle S,
Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald
K, Godfrey M, Gupta D, McPherson J, Malwadkar
P, Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS,
Brookes E, Cherry AB, Demirbas D, Tsankov AM,
Zon LI, Rubin LL, Feinberg AP, Meissner A,
Cowan CA, Daley GQ. A comparison of reprogramming methods. Nat Biotechnol (2014) 33, 58-63.
Kumar RM, Cahan P, Shalek A, Satija R, DaleyKeyser A, Li H, Zhang J, Pardee K, Gennert D, Trombetta JJ, Ferrante TC, Regev A, Daley GQ, Collins
JJ. Deconstructing the dynamic transcriptional
program of pluripotent stem cells. Nature (2014)
516, 56-61.
Cahan P, Morris SA, Collins JJ, Daley GQ. Defining
cellular identity through network biology. Cell
Cycle (2014) 13, 3313-3314.
Kumar RM, Cahan P, Shalek AK, Satija R,
DaleyKeyser AJ, Li H, Zhang J, Pardee K, Gennert
D, Trombetta JJ, Ferrante TC, Regev A, Daley GQ,
Collins JJ. Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature (2014) 4,
56-61.
Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG,
Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger
TM, Orkin SH, Nakano A, Daley GQ. Flow-induced
protein kinase A-CREB pathway acts via BMP
signaling to promote HSC emergence. J Exp Med
(2015) 212, 633-648.
Diaz MF, Li N, Lee HJ, Adamo L, Evans SM, Willey
HE, Arora N, Torisawa YS, Vickers DA, Morris SA,
Naveiras O, Murthy SK, Ingber DE, Daley GQ,
García-Cardeña G, Wenzel PL. Biomechanical
forces promote blood development through prostaglandin E2 and the cAMP-PKA signaling axis. J Exp
Med (2015) 212, 665-680.
Mi L, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA. Structure of bone morphogenetic protein 9 proVo LT, Daley GQ. De novo generation of HSCs from complex. Proc Natl Acad Sci USA (2015), 112,
somatic and pluripotent stem cell sources. Blood- 3710-3715.
(2015) 125, 2641-2648.
Daley lab, cont.
Kim J, Hudson NE, Springer TA. Force-induced
Shyh-Chang N, Daley GQ. Metabolic switches on-rate switching and modulation by mutations in
linked to pluripotency and embryonic stem cell gain-of-function von Willebrand diseases. Proc Natl
differentiation. Cell Metab (2015) 21, 349-350.
Acad Sci USA (2015), 112, 4648-4653.
Wang LD, Rao TN, Rowe RG, Nguyen PT, Sullivan
Roberts lab
JL, Pearson DS, Doulatov S, Wu L, Lindsley RC, Zhu
H, DeAngelo DJ, Daley GQ, Wagers AJ. Leukemia Hwang JH, Pores Fernando AT, Faure N, Andrabi S,
Hahn WC, Schaffhausen BS, Roberts TM. Polyomavi(2015) Feb 6. doi: 10.1038/leu.2015.19.
rus small T antigen interacts with yes-associated proJang IH, Lu YF, Zhao L, Wenzel PL, Kume T, Datta tein to regulate cell survival and differentiation. J Virol
SM, Arora N, Guiu J, Lagha M, Kim PG, Do EK, Kim (2014) 88, 12055-12064.
JH, Schlaeger TM, Zon LI, Bigas A, Burns CE, Daley
GQ. Notch1 acts via Foxc2 to promote definitive Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt
hematopoiesis via effects on hemogenic endotheli- SM, Roberts TM, Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the
um. Blood (2015) 125, 1418-1426.
eIF4B-dependent control of c-Myc translation. Curr
Schlaeger TM, Daheron L, Brickler TR, Entwisle S, Biol (2014) 24, 2274-2280.
Chan K, Cianci A, DeVine A, Ettenger A, Fitzgerald
K, Godfrey M, Gupta D, McPherson J, Malwadkar P, White EA, Kramer RE, Hwang JH, Pores Fernando AT,
Gupta M, Bell B, Doi A, Jung N, Li X, Lynes MS, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS,
Brookes E, Cherry AB, Demirbas D, Tsankov AM, Livingston DM, Howley PM. Papillomavirus E7 oncopZon LI, Rubin LL, Feinberg AP, Meissner A, Cowan roteins share functions with polyomavirus small T
CA, Daley GQ. A comparison of non-integrating antigens. J Viol (2015) 89, 2857-2865,
reprogramming methods. Nat Biotechnol (2015)
Wagner lab
33, 58-63.
Takeuchi K, Sun ZY, Li S, Gal M, Wagner G. NMR resoLoparo lab
nance assignments of the catalytic domain of human
Song D, Loparo JJ. Building bridges within the bac- serine/threonine phosphatase calcineurin in unligated
terial chromosome. Trends Gen (2015), 31, 164-173. and PVIVIT-peptide-bound states. Biomol NMR
Assign (2015) 9, 201-205.
Springer lab
Edmonds KA, Wagner G. (1)H, (13)C, and (15)N backDong X, Hudson NE, Lu C, Springer TA. Structural bone and sidechain chemical shift assignments for the
determinants of integrin β-subunit specificity for HEAT2 domain of human eIF4GI. Biomol NMR
latent TGF-β. Nat Struct Mol Biol (2014), 21, Assign (2015) 9,157-60.
1091-1096.
Hagn F, Wagner G. Structure refinement and memXia W, Springer TA. Metal ion and ligand binding of brane positioning of selectively labeled OmpX in phosintegrin α5β1. Proc Natl Acad Sci USA (2014), 111, pholipid nanodiscs. J Biomol NMR (2014) 61,
17863-17868.
249-260.
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