Syllabus & Scheme
for
Doctor of Philosophy (PhD)
in
Department of Biomedical Engineering
School of Technology,
North-Eastern Hill University, Mawkynroh,
Umshing, Shillong – 793 022
1
DEPARTMENT OF BIOMEDICAL ENGINEERING
SCHOOL OF TECHNOLOGY
NEHU, SHILLONG
Scheme of Ph. D. in Biomedical Engineering
Semester 1st
BRANCH: Biomedical Engineering
Sl.
No
Subject Code
SUBJECT NAME
(THEORY)
1
2
ST-1201
BM-1202
3
BM-1203x
EVALUATION SCHEME
(distribution of marks)
Credits
End Semester Examination (ESE)
Research Methodology
Advance Biomedical
Instrumentation
Elective I
100
100
4
4
100
4
Total
300
12
Total Marks: 300
Total Credits: 12
BM-1203x Elective:
1. BM-12031
2. BM-12032
3. BM-12033
:- Advance Biomaterial
:- Advance Biomechanics & Robotics
:- Advances in Nanomedicine
2
Subject nomenclature and coding :BM: - Biomedical Engineering
ST: - School of Technology
BM-1203x- x indicates the paper number.
XXXXX
Elective Subject Number
Elective Number
Subject Number in the Semester
0 for Theory and 1 for Practical/Drawing/Design
Semester Number
3
ELIGIBILITY FOR Ph.D. (BIOMEDICAL ENGINEERING)
i.
A candidate is eligible who has passed M. Tech./M. E. in Biomedical
Engineering/Biotechnology/ Electrical/ Electronics and Communication/ Mechanical/
Computer/ Instrumentation and Control Engineering or M. Sc. in Biomedical
instrumentation, Electronics, Biophysics, Instrumentation candidates having
completed M.Tech. degree in the above areas or M.D. / M.S. or students with Master’s
Degree in Physiotherapy (2 years program) from any UGC recognised University or
equivalent having secured a minimum of 60% aggregate marks (relaxable by 5% for
SC/ST candidates) applicable as per NEHU norms.
ii.
The admission will be based on the combined entrance test and interview conducted
by the department.
iii.
Admission will be as per applicable NEHU norms.
4
ST - 1201
RESEARCH METHODOLOGY
Credits = 4
Subject Code: ST - 1201.
Subject Name: RESEARCH METHODOLOGY
Marks Distribution: End Semester Examination = 100.
UNIT I
Types of Research: Types, Research process and steps in it, Hypothesis, Research proposals and aspects.
UNIT II
Research Design: Need, problem definition, variables, research design concepts, literature survey and review,
research design process, errors in research.
UNIT III
Ethics:-Ethics of Research, Plagiarism.
UNIT IV
Report Writing: Pre-writing considerations, thesis writing, formats of report writing, formats of publications in
research journals, use of standard tools like LaTeX.
Text Books
1. C. R. Kothari, Research Methodology, 2/e, New Age International Publisher, 2002.
2. S. R. Bajpai, Research Methodology, S. Chand and Sons, 2001.
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BM – 1202 ADVANCE BIOMEDICAL INSTRUMENTATION
Credits = 4
Subject Code: BM-1202
Subject Name: Advance Biomedical Instrumentation.
Duration of End Semester Examination: Three Hours.
UNIT I
Generation and recording of Bio potentials: Genesis and propagation of bio-signals, Electrode-electrolyte
interface, electrode– skin interface, half-cell potential. Types of electrodes, biomaterial used for electrode
designing, characteristics of bio-signals. Recording of ECG, EMG, EOG and EEG signals.
UNIT II
Amplifier characteristics: Need for bio-amplifier - single and differential bio-amplifier. Filtering, isolation
amplifiers and optical isolation- isolated DC and AC amplifier, chopper amplifier and power line interference.
UNIT III
Measurement of electrical parameters: Pulse and respiration rate measurements. Blood Pressure measurements,
electronic manometer, Blood flow and cardiac output measurement techniques, neural control mechanism
UNIT IV
Advance biomedical instruments and patient safety: ESU; pulse oximeter, cardiac pacemaker and defibrillators.
Electrical and patient safety, medical devices classification and their safety standards, different types of safety
circuits for medical equipment and measures to reduce shock hazards.
Text Books:
1. Joseph J. Carr and John M. Brown, Introduction to Biomedical Equipment Technology, Pearson Education,
2004.
2. John G. Webster, Medical Instrumentation Application and Design, John Wiley and sons, 2004.
4. Joseph Bronzino, Biomedical Engineering and Instrumentation, PWS Engg., 2010.
References Books:
1. Leslie Cromwell, Biomedical Instrumentation and measurement, Prentice hall of India, 2007.
2. Khandpur R.S, Handbook of Biomedical Instrumentation, Tata McGraw-Hill, 2003.
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ELECTIVE-I
BM-12031
ADVANCE BIOMATERIALS
Credits = 4
Subject Code: BM- 12031
Subject Name: Advance Biomaterials.
Duration of End Semester Examination: Three Hours.
UNIT I
Biomaterials: Structure and properties, classification- chemical bonding, crystalline, amorphous, melting,
solidification, nucleation, phase diagrams and applications.
UNIT II
Biomaterials in medical application: Metal based alloys (including shape memory alloys). Processing and
characterization of ceramics and glasses-bio-ceramics. Medical applications of Pyrolitic carbon, Carbon nanotubes.
UNIT III
Bio-polymers: Classification, polymerization and their structure-properties relationship. Study of biodegradable
and natural polymers with their characterization. Preparation and synthesis of drug delivery systems from different
biomaterials-liposomes, mesosome and polymeric nano-particles.
UNIT IV
Fabrication of biomaterials: Common fabrication processes. Biomimetic synthesis, synthesis of fiber and wire,
porous materials, direct moulding technique, different advanced fabrication techniques. Characterization of
biomaterials, implant and biosensor design.
Text Books:
1. Buddy D. Ratner, Biomaterials Science: An Introduction to Materials in Medicine, Academic Press, San
Diego, 1996.
2. Sujata V. Bhat, Biomaterials, Narosa Publishing House, 2002.
3. J. B. Park, Biomaterials - Science and Engineering, Plenum Press, 1984.
4. Burdick, Biomaterial for Tissue Engineering Applications, Panima, 2012.
Reference Books:
1. Ratner, Biomaterials Science: An Introduction to Materials in Medicine 3rd Ed.Panima, 2011.
2. S. Ramakrishna, Biomaterials: A Nano Approach, Panima, 2011.
3. A. Kulshrestha, Biomaterials, Panima, 2011.
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ELECTIVE-I
BM-12032
ADVANCE BIOMECHANICS AND ROBOTICS
Credits = 4
Subject Code: BM -12032
Subject Name: Advance Biomechanics and Robotics
Duration of End Semester Examination: Three Hours.
UNIT I
Biomechanical concepts: Biomechanics principles, kinesiology, kinematics and dynamics of motion, types of
body motion, kinematics concepts, anatomical axis and corresponding movements of the body parts.
UNIT II
Tissue and Biofluid mechanics: Mechanics of body tissues, joint-articulating surface motion, cochlear and
vestibular mechanics, blood flow dynamics and circulatory fluid mechanics.
UNIT III
Exercise Biomechanics and Ergonomics: Sports and exercise biomechanics, study and analysis of human
movement, factors affecting mechanical work in humans, ergonomic designing and applications.
UNIT IV
Robotics: Introduction to Robotics, Newton Euler formulation, degrees of freedom, concepts in the designing of
artificial limbs, electrical stimulation techniques- FES, NMES, basic rehabilitation principles of assistive
technology assessment and sensory rehabilitation.
Text Books:
1. Schnek & Bronzino, Biomechanics-Principles and Applications, CRC Press, 2004.
2. J D Bronzino, Biomedical Engineering Handbook, CRC Press, 2002.
3. John D Enderle, Introduction to Biomedical Engineering, Academic Press Series, 2004.
4. Lee Waite & Jerry Fine, Applied Biofluid Mechanics, McGraw Hill, 2002.
Reference Books:
1. Peterson & Bronzino, Biomechanics-Principles and Applications, CRC Press, 2002.
2. Mofrad & Kamm, Cytoskeleton Mechanics: Models & Measurements, Cambridge Press, 2004.
3. Fung Y.C., Biomechanics, Springer Verlag,1984.
4. S Sunder, Text book of Rehabilitation Jaypee Publishers, 2006.
5. M. Jamir, The Physics of Coronary blood Flow, Springer Publishers, 2004.
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ELECTIVE-I
BM-12033
ADVANCES IN NANOMEDICINE
Credits = 4
Subject Code: BM-100523.
Subject Name: Advances in Nanomedicine.
Duration of End Semester Examination: Three Hours.
UNIT I
Routes of drug administration: Types of routes, pharmacokinetics, drug transport, bioavailability and
biotransformation; Pharmacodynamics: principles and mechanism of drug action, dose response relationship, drug
potency and efficiency, combined effect of drug and factors modifying drug action.
UNIT II
Applications of Nanomedicine: Nanoparticles fabrication techniques and characterization, targeted cancer therapy,
Nanomedicine in diabetics.
UNIT III
Tumour physiology for nanomedicine: Tumour physiology and targeting using nanoparticles and nanostructures,
cancer hyperthermia, photodynamic therapy and immunotherapy.
UNIT IV
Nanomedicine in diagnostic applications: Prerequisites of biosensor, Biomarkers for cancer imaging and sensing,
different nanoparticles for (Iron oxide, gold, quantum dot) cancer imaging and diagnostic techniques.
Text Books:
1. Tripathi KD, Essentials of Medical Pharmacology,1995
2. Sebastian M, Haghi AK and Ninan N, Nanomedicine and Drug delivery, Apple Academic Press, 2013.
3. Kumar CSSR, Nanomaterials for cancer Therapy, Wiley VCH Verlag GmbH & Co. KGaA, 2006.
Reference Books:
1. Saltzman WM, Engineering Principles for Drug Therapy, Oxford University Press, 2001.
2. Wang B, Siahaan T and Soltero R, Drug delivery principles and applications, Wiley-Interscience, 2005.
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