CNS Drugs
The Role of Antidepressants in the
Management of Fibromyalgia Syndrome
A Systematic Review and Meta-Analysis
Winfried Häuser et al.
Supplemental Digital Content
This Supplemental Digital Content contains the list of studies referred to in the full
version of this article, which can be found at http://adisonline.com/cnsdrugs
© 2012 Adis Data Information BV. All rights reserved.
Supplementary digital content 6: Included and excluded RCTs with TCAs
Included
1. Carette S, McCain GA, Bell DA, Fam AG. Evaluation of amitriptyline in primary
fibrositis. A double-blind, placebo-controlled study. Arthritis Rheum 1986;29:655-659.
2. Carette S, Bell MJ, Reynolds WJ, et al. Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind
clinical trial. Arthritis Rheum 1994;37:32-40.
3. Carette S, Oakson G, Guimont C, Steriade M. Sleep electroencephalography and
the clinical response to amitriptyline in patients with fibromyalgia. Arthritis
Rheum1995;38:1211-1217.
3. Caruso I, Sarzi Puttini PC, Boccassini L, Santandrea S, Locati M, Volpato R,
Montrone F, Benvenuti C, Beretta A. Double-blind study of dothiepin versus
placebo in the treatment of primary fibromyalgia syndrome. J Int Med Res 1987
;15:154-9
4. Ginsberg F, Mancaux A, Joos E et al. A randomized placebo-controlled trial
of sustained-release amitriptyline in primary fibromyalgia. J Musculoskel
Pain 1996;4:37-47
5. Goldenberg DL, Felson DT, Dinerman H. A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia. Arthritis
Rheum 1986;29:1371-1377.
6. Goldenberg D, Mayskiy M, Mossey C, Ruthazer R, Schmid C. A randomized,
double-blind crossover trial of fluoxetine and amitriptyline in the treatment of
fibromyalgia. Arthritis Rheum 1996;39:1852-9.
7. Hannonen P, Malminiemi K, Yli-Kerttula U, Isomeri R, Roponen P. A randomized,
double-blind, placebo-controlled study of moclobemide and amitriptyline in the
treatment of fibromyalgia in females without psychiatric disorder. Br J Rheumatol
1998;37:1279-86
8. Heymann RE, Helfenstein M, Feldman D. A double-blind, randomized, controlled
study of amitriptyline, nortriptyline and placebo in patients with fibromyalgia. An
analysis of outcome measures. Clin Exp Rheumatol 2001;19:697-702
9. Kempenaers C, Simenon G, Vander Elst M, et al. Effect of an antidiencephalon
immune serum on pain and sleep in primary fibromyalgia. Neuropsychobiology
1994;30:66-72.
10. Scudds RA, McCain GA, Rollman GB, Harth M. Improvements in pain responsiveness in patients with fibrositis after successful treatment with amitriptyline. J
Rheumatol Suppl 1989;19:98-103.
Excluded, reason for exclusion
1. Bibolotti E, Borghi C, Pasculii E, Regio F, Tavoni A, Baroni L, Castrogiovanni P,
Pasero G. The management of fibrositis. A double-blind comparison of maprotiline,
chlomipramine and placebo. Clin Trials 1986; 23:269-280. Outcomes not suited for
analysis
2. Eksioglu E, Yazar D, Bal A, Usan HD, Cakci A. Effects of Stanger bath therapy
on fibromyalgia. Clin Rheumatol 2007;26:691-4. No drug placebo control
3. Fors EA, Sexton H, Gotestam KG. The effect of guided imagery and amitriptyline
on daily fibromyalgia pain: a prospective, randomized, controlled trial. J Psychiatr
Res 2002;36:179-187. Combination with other active therapy
4. García J, Simón MA, Durán M, Canceller J, Aneiros FJ. Differential efficacy of
a cognitive-behavioral intervention versus pharmacological treatment in the
management of fibromyalgic syndrome. Psychol Health Med 2006;11:498
-506. No drug placebo control
5. Gür A, Karakoc M, Nas K, Cevik R, Sarac J, Ataoglu S. Effects of low power laser
and low dose amitriptyline therapy on clinical symptoms and quality of life in
fibromyalgia: a single-blind, placebo-controlled trial. Rheumatol Int 2002;22:188–93.
No drug placebo control
6. Isomeri R, Mikkelsson M, Latikka P, Kammonen K. Effects of amitriptyline and
cardiovascular Fitness Training on pain in Patients with Primary Fibromyalgia. J
Muscul Pain 1993;1:253–60. Combination with other therapy
7. Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B. Clinical usefulness of
amitriptyline in fibromyalgia: the results of 23 N-of-1 randomized controlled trials. J
Rheumatol 1991;18:447–51. Study type [N-1 study] and outcomes not suited for
analysis
8. Jang ZY, Li CD, Qiu L, Guo JH, He LN, Yue Y, Li FZ, Qin WY. Combination of
acupuncture, cupping and medicine for treatment of fibromyalgia syndrome: a multicentral randomized controlled trial. Zhongguo Zhen Jiu. 2010;30:265-9. Article in
Chinese. No drug placebo control, outcomes not suited for analysis
9. Joshi MN, Joshi R, Jain AP. Effect of amitriptyline vs. physiotherapy in
management of fibromyalgia syndrome: What predicts a clinical benefit? J Postgrad
Med 2009; 55:185-9. No randomisation, no drug placebo control
10. Targino RA, Imamura M, Kaziyama HH, Souza LP, Hsing WT, Furlan AD,
Imamura ST, Azevedo Neto RS. A randomized controlled trial of acupuncture added
to usual treatment for fibromyalgia. J Rehabil Med 2008;40:582-8. Combination with
other active therapy
11. Ware MA, Fitzcharles MA, Joseph L, Shir Y. The effects of nabilone on sleep in
fibromyalgia: results of a randomized controlled trial. Anesth Analg. 2010;110:604-10.
No drug placebo control