CURRICULUM VITAE
Ruoning Wang, Ph.D.
PRESENT TITLE AND AFFILIATION
DUAL/JOINT APPOINTMENT
Assistant Professor,
Department of Pediatrics
The Ohio State University School of Medicine
The Research Institute at Nationwide Children's Hospital
Investigator, Center for Childhood Cancer and Blood Disease
CITIZENSHIP AND VISA STATUS
Permanent resident
OFFICE ADDRESS
The Research Institute at Nationwide Children's Hospital
Investigator, Center for Childhood Cancer and Blood Disease
Investigator, Hematology/Oncology & BMT
700 Children's Drive, Rm. WA5019
Columbus, OH 43205-2696
Office: (614) 355-2980
Lab:
(614) 355-2660
FAX:
(614) 722-5895
Email: ruoning.wang@nationwidechildrens.org
EDUCATION
UNDERGRADUATE EDUCATION
06/1996
China Pharmaceutical
University
Nanjing, China
Bachelor of Science in
Medicinal Chemistry
GRADUATE EDUCATION
06/2002
Nanjing Medical University
Nanjing, China
1
Master of Science in
Biochemistry
Revised 4.15
08/2002-06/2007
University of Texas MD
Anderson Cancer Center
Houston, TX
Ph.D Genes & Development
POST-GRADUATE EDUCATION & TRAINING
06/2007-12/2007
03/2008-08/2013
University of Texas MD
Anderson Cancer Center
Houston, TX
St Jude Children Research
Hospital
Memphis, TN
Postdoctoral Fellow
Postdoctoral Fellow
Department of Immunology
ACADEMIC APPOINTMENTS
2013-present
Assistant Professor
Department of Pediatrics
The Ohio State University School of Medicine
SERVICE
INSTITUTIONAL/LOCAL ACTIVITIES
2013-present
Member
Childhood cancer center and BMT joint research retreat organizing committee
The Research Institute at Nationwide Children's Hospital
Columbus, OH
2013-present
Member
Childhood Cancer Grant committee
The Research Institute at Nationwide Children's Hospital
Columbus, OH
2013-present
Member
Clinical Scientific Review Committee/BMT
The Research Institute at Nationwide Children's Hospital
Columbus, OH
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Revised 4.15
2013-present
Member
OSU-ACS seed grant review committee
The Ohio State University
Columbus, OH
HONORS AND AWARDS
2006
GSBS Travel Award
UTH-GSBS & UT-MD Anderson Cancer Center
2006
Genes & Development Travel Award
Genes & Development Program
UT-MD Anderson Cancer Center
2006
Research Achievement Award (1st Place)
Genes & Development Program
UT-MD Anderson Cancer Center
2007
Alfred G. Knudson Outstanding Dissertation Award
UT-MD Anderson Cancer Center
2007
Presidents’ Research Scholar Award
UT-MD Anderson Cancer Center
2009-2012
George J. Mitchell Fellowship
St Jude Children Research Hospital
2011
AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award
American Cancer Society
2014-present
V Scholar Award
The V Foundation for Cancer Research
RESEARCH SUPPORT
ONGOING RESEARCH
PEER REVIEWED
Elsa Pardee Foundation
Wang (PI)
Oncogenic and metabolic addiction in neuroblastoma
Role: PI
$120,000
3
06/01/2014-11/30/2015
Revised 4.15
Bayer Healthcare Pharmaceuticals, Inc.
Wang (PI)
09/08/2014-09/07/2015
Targeting GABA metabolism in Cancer
The major goals of this one-year pilot project are to assess metabolic dependence of GABA
metabolic route in rhabdomyosarcoma cell lines.
Role: PI
$26,788
V-Foundation
Wang (PI)
11/15/2014-11/14/2016
Metabolic reprogramming and modulation of adaptive immunity in tumor microenvironment
Role: PI
$200,000
Grant #: N/A (PI: Wang)
07/01/2015-06/30/2016
0.12 calendar
CancerFree Kids
$ 45,000
The metabolic and therapeutic intervention in neuroblastoma
The major goals of this project are to determine the role of Myc in regulating metabolic
programs in neuroblastoma cells.
R21AI117547-01MPI (PI: Wang R, co-PI Zhang J)
07/01/2015-06/30/2017
1.8 calendar
NIH
$80,000
Metabolic dysregulation and therapeutic intervention in asthma
The major goals of this project are to understand the signaling mechanism of metabolic
regulation and assess the therapeutic potential of targeting metabolic pathway in murine asthma
model.
Grant #: 1R01AI114581-01 (PI: Wang)
03/01/2016-08/31/2020
2.4 calendar
NIH
$250,000
Metabolic programming in TH17 cells
The major goals of this project are to understand the signaling mechanism of metabolic
regulation in TH17 cells and assess the therapeutic potential of targeting metabolic pathway in
multiple sclerosis.
COMPLETED RESEARCH
PEER REVIEWED
OSU Cancer Center-ACS seed grant
Wang (PI)
03/01/2014-02/28/2015
Targeting Myc-dependent metabolic pathway in rhabdomyosarcoma
The major goals of this one-year pilot project are to assess Myc-dependent regulations on
metabolic programs in rhabdomyosarcoma cell lines.
Role: PI
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Revised 4.15
$30,000
Wang-RCSIRM_P&F-2014
Wang (PI)
Regional Metabolomics Resource Center at University of Kentucky
Role: PI
$32,000
06/01/2014-05/30/2015
Grant #: N/A (PI: Wang)
06/01/2015-08/30/2015
0.12 calendar
MBCG seed grant/OSU
$ 12,500
Metabolic reprogramming and therapeutic intervention in rhabdomyosarcoma
The major goals of this three month pilot project are to assess HIF1-mediated metabolic route in
rhabdomyosarcoma cell lines.
PENDING RESEARCH SUPPORT
PEER REVIEWED
Wang (PI)
01/01/2016-06/30/2017
American Cancer Society
Tumor Mediated Metabolic Modulation of Regulatory T cells
The major goals of this project are to determine the metabolic program and the metabolic
dependency of iTreg cells in the tumor microenvironment.
Role: PI
$650,000
PUBLICATIONS
ARTICLES IN PEER REVIEWED JOURNALS
1. He G, Siddik ZH, Huang Z, Wang R, Koomen J, et al. Induction of p21 by p53
following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr
21;24(18):2929-43. PMID: 15735718.
2. Yu JH, Shi JN, Deng ZH, Zhuang H, Nie X, Wang RN, Jin Y. Cell pellets from dental
papillae can reexhibit dental morphogenesis and dentinogenesis. Biochem Biophys Res
Commun. 2006 Jul 21;346(1):116-24. PMID: 16750168.
3. Pan S*, Wang R*, Zhou X, He G, Koomen J, et al. Involvement of the conserved
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adaptor protein Alix in actin cytoskeleton assembly. J Biol Chem. 2006 Nov
10;281(45):34640-50. PMID: 16966331. *Equal contribution
4. Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, et al. Regulation of
Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 2007 Mar
23;128(6):1119-32. PMID: 17382881.
5. Zhao Y, Haccard O, Wang R, Yu J, Kuang J, et al. Roles of Greatwall kinase in the
regulation of cdc25 phosphatase. Mol Biol Cell. 2008 Apr;19(4):1317-27. PMID:
18199678; PMCID: PMC2291418.
6. Pan S, Wang R, Zhou X, Corvera J, Kloc M, et al. Extracellular Alix regulates integrinmediated cell adhesions and extracellular matrix assembly. EMBO J. 2008 Aug
6;27(15):2077-90. PMID: 18636094; PMCID: PMC2516883.
7. Wu CF, Wang R, Liang Q, Liang J, Li W, et al. Dissecting the M phase-specific
phosphorylation of serine-proline or threonine-proline motifs. Mol Biol Cell. 2010 May
1;21(9):1470-81. PMID: 20219976; PMCID: PMC2861607.
8. Yu J, He H, Tang C, Zhang G, Li Y, Wang R, Shi J, Jin Y. Differentiation potential of
STRO-1+ dental pulp stem cells changes during cell passaging. BMC Cell Biol. 2010
May 8;11:32. PMID: 20459680; PMCID: PMC2877667.
9. Green DR, Wang R. Calcium and energy: making the cake and eating it too?. Cell. 2010
Jul 23;142(2):200-2. PMID: 20655464.
10. Wang R, Jung SY, Wu CF, Qin J, Kobayashi R, et al. Direct roles of the signaling kinase
RSK2 in Cdc25C activation during Xenopus oocyte maturation. Proc Natl Acad Sci U S
A. 2010 Nov 16;107(46):19885-90. PMID: 21041626; PMCID: PMC2993414.
11. Shi LZ*, Wang R*, Huang G, Vogel P, Neale G, et al. HIF1alpha-dependent glycolytic
pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg
cells. J Exp Med. 2011 Jul 4;208(7):1367-76. PMID: 21708926; PMCID:
PMC3135370. *Equal contribution
12. Bedford DC, Kasper LH, Wang R, Chang Y, Green DR, et al. Disrupting the CH1
domain structure in the acetyltransferases CBP and p300 results in lean mice with
increased metabolic control. Cell Metab. 2011 Aug 3;14(2):219-30. PMID: 21803292;
PMCID: PMC3163393.
13. Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, et al. The transcription factor Myc
controls metabolic reprogramming upon T lymphocyte activation. Immunity. 2011 Dec
23;35(6):871-82. PMID: 22195744; PMCID: PMC3248798.
14. Wang R, Green DR. The immune diet: meeting the metabolic demands of lymphocyte
activation. F1000 Biol Rep. 2012;4:9. PMID: 22615715; PMCID: PMC3342832.
15. Wang R, Green DR. Metabolic reprogramming and metabolic dependency in T cells.
Immunol Rev. 2012 Sep;249(1):14-26. PMID: 22889212; PMCID: PMC3422760.
16. Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green DR, Tessarollo L,
Casellas R, Zhao K, Levens D. c-Myc is a universal amplifier of expressed genes in
lymphocytes and embryonic stem cells. Cell. 2012 Sep 28;151(1):68-79. PMID:
23021216; PMCID: PMC3471363.
17. Wang R*, Green DR*. Metabolic checkpoints in activated T cells. Nat Immunol. 2012
Oct;13(10):907-15. PMID: 22990888. *Corresponding author
18. Verbist KC, Wang R, Green DR. T cell metabolism and the immune response. Semin
Immunol. 2012 Dec;24(6):399-404. PMID: 23313070.
19. Liu G, Bi Y, Wang R, Wang X. Self-eating and self-defense: autophagy controls innate
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immunity and adaptive immunity. J Leukoc Biol. 2013 Apr;93(4):511-9. PMID:
23271703.
20. Martinez J, Verbist K, Wang R, Green DR. The relationship between metabolism and
the autophagy machinery during the innate immune response. Cell Metab. 2013 Jun
4;17(6):895-900. PMID: 23747248; PMCID: PMC3696504.
21. Liu G, Bi Y, Wang R, Shen B, Zhang Y, et al. Kinase AKT1 negatively controls
neutrophil recruitment and function in mice. J Immunol. 2013 Sep 1;191(5):2680-90.
PMID: 23904165.
22. Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G,
Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green
DR. Widespread mitochondrial depletion via mitophagy does not compromise
necroptosis. Cell Rep. 2013 Nov 27;5(4):878-85. PMID: 24268776; PMCID:
PMC4005921.
23. Wang T, Liu G, Wang R. The Intercellular Metabolic Interplay between Tumor and
Immune Cells. Front Immunol. 2014;5:358. PMID: 25120544; PMCID: PMC4112791.
24. Liu G, Bi Y, Wang R, Yang H, Zhang Y, et al. Targeting S1P1 receptor protects against
murine immunological hepatic injury through myeloid-derived suppressor cells. J
Immunol. 2014 Apr 1;192(7):3068-79. PMID: 24567529.
25. Caro-Maldonado A, Wang R, Nichols AG, Kuraoka M, Milasta S, et al. Metabolic
reprogramming is required for antibody production that is suppressed in anergic but
exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr
15;192(8):3626-36. PMID: 24616478; PMCID: PMC3984038.
26. Wu CF, Liu S, Lee YC, Wang R, Sun S, et al. RSK promotes G2/M transition through
activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 2014 May
1;33(18):2385-94. PMID: 23708659; PMCID: PMC4026278.
27. Yang H, Bi Y, Xue L, Wang J, Lu Y, Zhang Z, Chen X, Chu Y, Yang R, Wang R, Liu
G. Multifaceted Modulation of SIRT1 in Cancer and Inflammation. Crit Rev Oncog.
2015;20(1-2):49-64. PMID: 25746104.
28. Liu G*, Bi Y, Xue L, Zhang Y, Yang H, Chen X, Lu Y, Zhang Z, Liu H, Wang X, Wang
R*, Chu Y, Yang R. Dendritic cell SIRT1-HIF1α axis programs the differentiation of
CD4+ T cells through IL-12 and TGF-β1. Proc Natl Acad Sci U S A. 2015 Mar
3;112(9):E957-65. doi: 10.1073/pnas.1420419112. Epub 2015 Feb 17. PMID: 25730867;
PMCID: PMC4352801. *Corresponding author
29. Slack M, Wang T, Wang R. T cell metabolic reprogramming and plasticity. Mol
Immunol, Epub 2015. PMID:26277274
30. Liu H, Bi Y, Hu X, Wang J, Lu Y, Chen X, Zhang Z, Li C, Wang Y, Yang H, Chu Y,
Zhao Y*, Wang R*, Liu G*. Glucocoticoid-receptor promotes the function of myeloidderived suppressor cell by suppressing HIF1α-dependent glycolysis. MCB, In Revision.
*Corresponding author
31. Verbist KC, Guy C, Milasta S, Wang R, Green DR. Metabolic maintenance of cell
asymmetry following divisions in activated T lymphocytes. Nature, In Revision
32. Liu L, Lu Y, Martinez J, Wang T, Milasta S, Wang J, Yang M, Liu G, Green DR and
Wang R, Pro-inflammatory stimulation suppresses proliferation and shifts the regulation
of macrophage metabolism from a Myc-dependent to a HIF1α-dependent manner.
Submitted.
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Revised 4.15
BOOK CHAPTERS
1. Chapter “Metabolism of Sugar” in Biochemistry and Molecular Biology (116-131), 1st
Ed., Aug. 2001, Science Press, Beijing, China
2. Chapter “Metabolism of Sugar” in Medical Biochemistry (43-61), 1st Ed., May 1999,
Southeast University Press, Nanjing. China
3. Chapter “Mechansims of G2 Phase Arrest in DNA Damage-Induced Checkpoint
Response” in Cancer Drug Discovery and Development Series, 1st Ed., 2010, Humana
Press, USA
4. Chapter “Metabolic Regulation of Immunity” in Kelley & Firestein’s Textbook of
Rheumatology, 10th Ed., In Press, Elsevier, USA
EDITORIALS AND REVIEW ACTIVITIES
JOURNAL REVIEWER
2013-present
2013-present
2013-present
2013-present
2013-present
2013-present
2013-present
2013-present
Ad Hoc Reviews for BMC Cancer
Ad Hoc Reviews for Cell Death & Differentiation
Ad Hoc Reviews for Cell Metabolism
Ad Hoc Reviews for Frontie Immunology
Ad Hoc Reviews for International Immunopharmacology
Ad Hoc Reviews for JBiotechnology
Ad Hoc Reviews for Oncotarget
Ad Hoc Reviews for Trend in Immunology
TEACHING
LECTURES/PRESENTATIONS
NATIONAL/INTERNATIONAL
2007
Grady Saunders Student Lecture
Gene & Development Program
UT MD Anderson Cancer Center
2007
Presidents’ Research Scholar symposium
GSBS
University of Texas Health Center at Houston
2008
Experimental Therapeutics Departmental Seminal
Department of Experimental Therapeutics
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UT MD Anderson Cancer Center
2008
Postdoctoral Annual
St Jude Children Research Hospital
2011
Metabolic Regulation and Cancer (Mini-symposium )
American Cancer Society Annual Meeting
2012
Regulation of Lymphocyte Signaling
Keystone Symposia
2012
Frontiers of Immunology in Health and Diseases
Cold Spring Harbor Conference
Suzhou Dushu Lake Conference Center
China
2015
University of Kentucky
Metabolomics Symposium
LOCAL/REGIONAL
2014
Fueling Immunity: Metabolic Reprogramming and Metabolic
Checkpoint in Lymphocyte
NCG/OSU
Columbus, OH
2014
Metabolic Reprogramming in Pediatric Cancer: starving beast and
beyond
INSTITUTIONAL
2014
Fueling Immunity: Metabolic Reprogramming and Metabolic
Checkpoint in Lymphocyte
NCH/OSU
Columbus, OH
2014
Metabolic Reprogramming in Pediatric Cancer: starving beast and
beyond
NCH/OSU
Columbus, OH
2014
Metabolic Reprogramming & Targeting in Pediatric Blood Cancer: --1st step to a grand opening
NCH/OSU
Columbus, OH
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2014
Metabolic targeting MYCN amplified neuroblastoma
NCH/OSU
Columbus, OH
DIRECT SUPERVISION
POSTDOCTORAL RESEARCH FELLOWS
2014-present
2015-present
Tingting Wang
Gaojian Lian
CLINICAL RESIDENTS AND FELLOWS
2013-present
Maria Slack
CONFERENCES AND SYMPOSIA
LOCAL/REGIONAL DISTINGUISHED ACTIVITIES
1. Scientific judges for poster presentations; The Research Institute at Nationwide
Children’s Hospital (2014)
PROFESSIONAL MEMBERSHIPS AND ACTIVITIES
2013-present
Member, American Association for Cancer Research
I have reviewed the curriculum vitae for completeness and accuracy and agree with its content.
Signature __________________________
Date______________________________
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