lecture sessions—scientific sessions scientific sessions

LECTURE SESSIONS—SCIENTIFIC SESSIONS

SCIENTIFIC SESSIONS

AGA State-of-the-Art Lecture (2000)

8:00 AM - 9:00 AM

Room: 149AB, WCC

Chairs: Scott B. Snapper, JeanMarie Houghton

AGA Translational Symposium (2010)

8:00 AM - 9:30 AM

Room: 146C, WCC

Chairs: Alessio Fasano, Philip M. Sherman

Sponsored by: Regulatory Peptides, Cell Signaling &

Molecular Biology

NRG AND NSG HUMANIZED MICE-AVATARS FOR

STUDYING DISEASE

Participants will be able to:

• Appreciate the impact of transgenic mice with humanized immune systems on developing new disease models; and

• Learn the potential use of mice with humanized immune systems for immunomodulatory therapy of autoimmune disease and cancer.

8:00 NRG and NSG Humanized Mice-Avatars for

Sp132 Studying Disease

Leonard Shultz

AGA Research Symposium (2005)

8:00 AM - 9:30 AM

Room: 150A, WCC

Chairs: K. S. Murthy, Keith A. Sharkey

Sponsored by: Neurogastroenterology & Motility

NGM CUTTING-EDGE: NEW ROLES FOR OLD

CELLS


• Learn about emerging concepts in how motility and sensation are regulated by intrinsic and extrinsic elements; and

• Obtain information on cutting-edge tools for investigation of the enteric nervous system and sensory nerves.

8:00 How Sensory Neurons Sense Bacteria

Sp133 Isaac Chiu

8:30 Macrophages and GI Motility

Sp134 Milena Bogunovic

9:00 Fibroblasts and Gut Motility

Sp135 Kenton M. Sanders

Sponsored by: Growth, Development & Child Health

GUT MICROBIOME AND CLINICAL OUTCOMES IN

PEDIATRICS


• Discuss the current evidence on how gut microbiome is established at birth and influenced by host and environmental factors;

• Present evidence on the role of gut microbiome in the pathogenesis of obesity, food allergies, and IBD; and

• Review potential treatment and preventive interventions by manipulating gut microbiome.

8:00 Presentation of Research Mentor Award:

Richard J. Grand, MD

8:06 How Gut Microbiome Is Established: Lessons

Sp136 Learned From Premature Infants

Phillip I. Tarr

8:27

Sp137

Microbiome and Obesity

Lee M. Kaplan

8:48 Microbiome and Food Allergies

Sp138 Richard S. Blumberg

9:09 Microbiome and IBD

Sp139 Eric Alm

ASGE Clinical Symposium (2015)

8:00 AM - 9:30 AM

Room: 103A, WCC

Chairs: Adam Slivka, Michael L. Kochman

ERCP ESSENTIALS

8:00 Optimal Techniques for Selective Biliary

Sp140 Cannulation

Amrita Sethi

8:15

Sp141

Precut Techniques for Biliary Access

Martin L. Freeman

8:30 Caught Between a Rock and a Hard Place:

Sp142 Challenging Stones

John J. Vargo II

8:45 Identifying and Managing ERCP

Sp143 Complications

Douglas G. Adler

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AGA Research Forum (2020)

8:00 AM - 9:30 AM

Room: 154, WCC

Chairs: Chin Hur, Uri Ladabaum

Sponsored by: Clinical Practice; Imaging & Advanced

Technology

BENDING THE COST CURVE IN

GASTROENTEROLOGY


• Identify cost-effective means to treat ulcerative colitis;

• Determine whether interventions to increase colon cancer screening are economically feasible; and

• Compare the effectiveness of diet or steroids to treat eosinophilic esophagitis.

8:00

#1

8:18

#2

Potential Effectiveness and Cost-

Effectiveness of Tailoring Screening to

Predicted Colorectal Cancer Risk

Uri Ladabaum*, Ajitha Mannalithara, Aya

Mitani, Alice S. Whittemore, Manisha Desai

Direct Costs in Patients With Celiac Disease -

A Retrospective Claims Analysis

Stefano Guandalini*, Namita Tundia, Roopal

Thakkar, Srikesh Arunajadai, Dendy Macaulay,

Kirk Essenmacher, Mahesh Fuldeore

8:36

#3

8:54

#4

9:12

Sp144

Cost Per Clinical Outcomes With Biologics for the Treatment of Moderately to Severely

Active Ulcerative Colitis

Jeroen P. Jansen, Reema Mody*, Haridarshan

Patel, Maria Lorenzi, Iulia Ursan, Mark Alberton

Six-Food Elimination Diet or Topical Steroids for First-Line Treatment of Eosinophilic

Esophagitis: A Cost-Utility Analysis

Cary C. Cotton*, Sarah Hiller, Daniel J. Green,

W. Asher Wolf, Stephanie B. Wheeler, Nicholas

J. Shaheen, Evan S. Dellon

The Role of Health Economics in Modern

Medicine

Chin Hur


8:00 AM - 9:30 AM

Room: 147, WCC

Chairs: Ashwin N. Ananthakrishnan, Gilaad Kaplan

Sponsored by: Immunology, Microbiology & Inflammatory

Bowel Diseases; Clinical Practice

EPIDEMIOLOGY OF INFLAMMATORY BOWEL

DISEASE


• Characterize the association between dietary zinc intake and the subsequent risk of Crohn's disease or ulcerative colitis in two prospective cohorts of nurses;

• Assess the effect of rural residence on the subsequent risk of Crohn's disease or ulcerative colitis in two

Canadian provinces; and

• Estimate the effects of medications, including antibiotics, statins, estrogen, and acne medications on the risk of inflammatory bowel disease in a large

American claims database.

8:00

#5

Zinc Intake and Risk of Crohn's Disease and

Ulcerative Colitis: A Prospective Cohort Study

Ashwin N. Ananthakrishnan*, Hamed Khalili,

Mingyang Song, Leslie M. Higuchi, James M.

Richter, Andrew T. Chan

8:15

#6

8:30

#7

8:45

#8

The Influence of Rural/Urban Environment on the Risk of Inflammatory Bowel Disease in

Canada: A Population-Based and Birth Cohort

Study From the Canadian Gastro-Intestinal

Epidemiology Consortium (CanGIEC)

Eric I. Benchimol*, Gilaad Kaplan, Geoffrey C.

Nguyen, Jennifer L. Jones, Astrid Guttmann,

Beth K. Potter, Christina A. Catley, Fox E.

Underwood, Zoann Nugent, Laura Targownik,

Desmond Leddin, Anthony R. Otley, Charles N.

Bernstein

Statins Associated With Decreased Risk of

New Onset IBD

Ryan C. Ungaro*, Ashish Atreja, Helena Chang,

Jean-Frederic Colombel

Receiving Corticosteroids Therapy Is

Associated With a Poor Outcome in Patients

With Elderly-Onset Ulcerative Colitis: A

Population-Based Study

Benjamin Pariente*, Mathurin Fumery, Hélène

Sarter, Cloe Charpentier, Laura Armengol-

Debeir, Luc Dauchet, Eric Laberenne, hugues

Coevoet, Laurent Peyrin-Biroulet, Corinne

Gower-Rousseau, Guillaume Savoye

9:00

#9

9:15

#10

Extraintestinal Manifestations of Inflammatory

Bowel Disease Are Significantly More

Frequent Among African Americans

Compared to Caucasians

Jemilat Badamas*, Ming-Hsi Wang, Mark

Lazarev, Geoffrey C. Nguyen, Steven R. Brant

No Difference in Ulcerative Colitis Colectomy

Rate in Pre and Post Biologic Era

Indrani Banerjee, Ashwin N. Ananthakrishnan,

Thomas H. Chelius, Aniko Szabo, Qun Xiang,

Kia Saeian, Lilani Perera*

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8:00 AM - 9:30 AM

Room: 151A, WCC

Chairs: Andrea Todisco, Wael El-Rifai

Sponsored by: Gastrointestinal Oncology; Esophageal,

Gastric & Duodenal Disorders; Regulatory Peptides, Cell

Signaling & Molecular Biology; Imaging & Advanced

Technology

GASTRIC NEOPLASMS: PRECURSORS, BIOLOGY,

DIAGNOSIS AND THERAPY


• Understand the basic biology underlying gastric neoplasms.

8:00

#11

Inhibition of KRAS Activation Ameliorates

Pre-Cancerous Metaplastic Conversion in the

Mouse Stomach

Eunyoung Choi*, Audrey M. Hendley, Jennifer

M. Bailey, Steven Leach, James R. Goldenring

8:15

#12

8:30

#13

Role of CDH1, TGF b

R2, and KRAS Mutations in the Carcinogenesis of Stomach

Yoshihiro Hirata*, Nobumi Suzuki, Hiroto

Kinoshita, Hideaki Ijichi, Kosuke Sakitani,

Sozaburo Ihara, Takako Serizawa, Hayato

Nakagawa, Kazuhiko Koike

DARPP32: A Bridge Between Pro-

Inflammatory Signaling and Angiogenesis in

Gastric Cancer

Zheng Chen*, Shoum Zhu, DunFa Peng, Abbes

Belkhiri, Wael El-Rifai

8:45

#14

9:00

#15

9:15

#16

EBI3 Regulates the Development of Atrophic

Gastritis and Progression to Gastric Cancer by

Regulating IL-17A/IL-22 Production by CD4+

T-Cells

Thanh-Long M. Nguyen*, Kevin Bockerstett,

Eric Ford, Jason C. Mills, Richard DiPaolo

Restoration of Notch1 Receptor Expression

Contributes to Tumor Suppressive Roles in

Gastric Cancer Cells Through the Regulation of p53

Xiaoyi Jin*, Naoki Asano, Akira Imatani, Yutaka

Kondo, Katsunori Iijima, Tomoyuki Koike, Tooru

Shimosegawa

Loss of TFF1 Promotes H. pylori-Induced b

-

Catenin Activation in Gastric Carcinogenesis

Mohammed Soutto*, Shoum Zhu, Judith

Romero-Gallo, Uma S. Krishna, Waqqas Fazili,

M. Blanca Piazuelo, Abbes Belkhiri, Alexander

Zaika, Richard M. Peek Jr., Wael El-Rifai


8:00 AM - 9:30 AM

Room: 146AB, WCC

Chairs: David Boone, Theresa T. Pizarro


Bowel Diseases

IBD: CYTOKINES, SIGNALING AND RECEPTORS


• Understand the role of important cytokines, signaling pathways and receptors in the pathogenesis of intestinal inflammation.

8:00

#17

Increased Expression of LRRK2, a

Susceptibility Gene of IBD Results in

Enhanced Pro-Inflammatory Response and

Severe Experimental Colitis

Tetsuya Takagawa*, Masaki Tajima, Kazutoshi

Hori, Shiro Nakamura, Atsushi Kitani, Ivan J.

Fuss, Warren Strober

8:15

#18

8:30

#19

NOD2-Dependent IL-33 Expression Is an

Important Mechanism in the Pathogenesis of

Inflammatory Bowel Disease (IBD)

Chiara L. Cominelli*, Xiaoming Wang, Theresa

T. Pizarro, Derek Abbott

Role and Species-Specific Expression of

Colon T-Cell Homing Receptor GPR15 in

Colitis

Linh P. Nguyen*, junliang pan, Theresa T. Dinh,

Husein Hadeiba, Edward O'Hara, Ahmad

Ebtikar, Arnulf Hertweck, Refik Gökmen,

Graham M. Lord, Richard Jenner, Eugene C.

Butcher, Aida Habtezion

8:45

#20

9:00

#21

9:15

#22

IL-33 Signaling Augments Epithelial Barrier

Function In Vitro and Protects Mice From

Oxazolone Colitis

Amanda Waddell*, Jefferson Vallance, Preston

D. Moore, Amy Hummel, Shiva Shanmukhappa,

Kay Washington, Susumu Nakae, Andrew

McKenzie, Keith T. Wilson, Lee Denson, Simon

P. Hogan, Michael J. Rosen

Genetic Modulation of PPAR g

Phosphorylation Decreases the Severity of

Experimental Colitis in Mice

Sarah N. Flier*, Gregory McElroy, Peter-James

H. Zushin, Alexander S. Banks

IL-34 Antibody Ameliorates Experimental

Colitis by Alternating IL-12p40 Expression in

Macrophages

Takuya Yoshino*, Minoru Matsuura, Hiroshi

Nakase

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8:00 AM - 9:30 AM

Room: 150B, WCC

Chairs: Camilla Richmond, Blair B. Madison

Sponsored by: Intestinal Disorders; Growth,

Development & Child Health; Gastrointestinal Oncology

INTESTINAL STEM CELLS, DEVELOPMENTAL

BIOLOGY, IN VIVO (ORGANOIDS/ENTEROIDS)


• Get exposure to new discoveries in the field and experimental approaches;

• Discuss new findings and alternative interpretations; and

• Discuss current concepts in the field and major problems left unsolved.

8:00

#23

8:15

#24

Schlafen 12 Regulates Human Enterocyte

Differentiation by Binding to Serpin B12

Marc D. Basson*, Lakshmi S. Chaturvedi, Kelian

Sun, Pavlo L. Kovalenko, Leslie A. Kuhn, Mary

Walsh

Modeling Familial Adenomatous Polyposis

With Induced Pluripotent Stem Cells

Cesar Sommer, Andreia Gianotti-Sommer,

Gustavo Mostoslavsky*

8:30

#25

8:45

#26

9:00

#27

9:15

#28

Intestinal Epithelial Cell Specific Deletion of

Nfkb2 Protects Against Immune Cell Derived

Damage-Inducing Factors in an Enteroid and

Bone Marrow Derived Dendritic Cell Co-

Culture System

Michael D. Burkitt, Lauren G. Jones, Jorge

Caamano, David M. Pritchard, Carrie A.

Duckworth*

The Cellular Plasticity of Fetal and Adult

Intestinal Epithelium and Its Functional

Evaluation by Grafting Assay

Shiro Yui*, Jordi Guiu, Pawel Schweiger,

Carsten F. Rundsten, Kim Jensen

Neutral Na + Absorption and Fluid/Anion

Secretion Are Not Separated Processes in the

Human Enteroid Model

Jennifer Foulke-Abel*, Julie In, Nicholas C.

Zachos, Olga Kovbasnjuk, Mark Donowitz

Bile Acids Regulate Colonic Stem Cell

Functions by Promoting Goblet Cell

Differentation: In Vivo and Human Colonoid

Studies

Jun Gao*, Hui Zhou, Stacy Finkbeiner, Jason

Spence, Chung Owyang


8:00 AM - 9:30 AM

Room: 156, WCC

Chairs: Beth McCormick, Neelendu Dey

Sponsored by: Intestinal Disorders;

Neurogastroenterology & Motility

MICROBES, INNATE IMMUNITY, PATHOGENESIS,

INFLAMMATION


• Be exposed to new discoveries in the field and experimental approaches;



8:00

#29

Lacking Vitamin D Receptor Leads to

Intestinal Dysbiosis

Dapeng Jin, Shaoping Wu, Yong-guo Zhang,

Rong Lu, Jun Sun*

8:15

#30

8:30

#31

Role of Long Polar Fimbriae in the

Interactions of Enterohemorrhagic

Escherichia coli With Peyer's Patches and

Inhibition by a Probiotic Yeast

Charlotte Cordonnier*, Jonathan Thévenot,

Lucie Etienne-Mesmin, Amandine Rougeron,

Sandra Renier, Stéphanie Blanquet-Diot,

Nicolas Barnich, Valérie Livrelli

‘Helicobacter Sanguini', a Novel Helicobacter

Isolated From Cotton-Top Tamarins With

Ulcerative Colitis, Induces Typhlocolitis in

Germfree C57BL/6 Il10 -/Mice

Zeli Shen*, Anthony Mannion, Mark T. Whary,

Sureshkumar Muthupalani, Alexander Sheh,

James G. Fox

8:45

#32

9:00

#33

9:15

#34

TIR-Domain Containing Adapter-Inducing

Interferonb

(TRIF) Promotes Early

Phagocytosis in Response to Gram-Negative

Enteropathogens

Saravana Kanagavelu*, Claudia Flores,

Masayuki Fukata

Intestinal Highly-Mobility Group Box1

(HMGB1) Protects Mice From Bacterial-Colitis

Through the STAT3 Signaling Pathway

Yong-guo Zhang, Xiaorong Zhu, Shaoping Wu,

Jeannette S. Messer, Rong Lu, Eugene B.

Chang, Jun Sun*

Human Intestinal Epithelial Response to

Gastrointestinal Virus Infection Using

Enteroids

Sarah E. Blutt*, Kapil Saxena, Sue E. Crawford,

James R. Broughman Jr, Margaret E. Conner,

Khalil Ettayebi, Umesh C. Karandikar, Xilei

Zeng, Julie In, Jennifer Foulke-Abel, Nicholas

C. Zachos, Olga Kovbasnjuk, Mark Donowitz,

Mary K. Estes

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8:00 AM - 9:30 AM

Room: 158, WCC

Chairs: Miriam B. Vos, Rohit Kohli

Sponsored by: Obesity, Metabolism & Nutrition;

Esophageal, Gastric & Duodenal Disorders;


OBESITY: BASIC AND CLINICAL STUDIES


• Understand normal physiologic regulation of mechanisms contributing to body mass and metabolic state, as well as disturbances that occur in obesity and diabetes; and

• Understand mechanisms by which obesity and its metabolic complications are ameliorated by bariatric surgery and other therapeutic approaches.

8:00

#35

Leptin Is Required for Glucose Homeostasis and Weight Maintenance After Roux-en-Y

Gastric Bypass in Mice

Mohamad Mokadem*, Juliet F. Zechner, Aki

Uchida, Vincent Aguirre

8:15

#36

8:30

#37

Nutrigenetic-Guided Dietary Intervention and

Weight Loss: A Randomized Controlled

Feasibility Trial

Jeremy Egnatios, Karen A. Frankwich, Mandy

L. Kenyon, Thomas Rutledge, Patricia S. Liao,

Samir Gupta, Karen Herbst, Amir Zarrinpar*

One-Year Follow-Up and Physiological

Alterations Following Endoscopic Sleeve

Gastroplasty for Treatment of Obesity

Barham K. Abu Dayyeh*, Andres Acosta, Mark

Topazian, Elizabeth Rajan, Michael Camilleri,

Christopher J. Gostout

8:45

#38

9:00

#39

9:15

#40

Effect of the GLP-1 Analogue Exenatide on

Functional Connectivity Within Hedonic and

Homeostatic Brain Networks in Lean and

Obese Women

Kristen Coveleskie*, Lisa A. Kilpatrick, Arpana

Gupta, Cody Ashe-McNalley, Jean Stains,

Claudia P. Sanmiguel, Emeran A. Mayer

Duodenal Spinal Nerves Expressing the

Vanilloid Receptor TRPV1 Are Important

Mediators of the Post-Prandial Glycemic

Response

Liansheng Liu, Sonal Patel, Qian Li, Pankaj J.

Pasricha*

Effect of Roux-en-Y Gastric Bypass and

Hypocaloric Diet on Bile Acids Synthesis

Erick Castillo*, Nicolas F. Quezada, Fernando

Pimentel, Rodrigo Munoz, Veronica Irribarra,

Lorena Azocar, Dannae Turiel, Hector Molina,

Palmenia Pizarro, Alejandra Alarcón, Fidel A.

Allende, Sandra Solari, Juan F. Miquel, Alex

Escalona


8:00 AM - 9:30 AM

Room: 206, WCC

Chairs: Richard S. Kwon, James J. Farrell

Sponsored by: Pancreatic Disorders; Clinical Practice;

Imaging & Advanced Technology; Gastrointestinal

Oncology

PANCREATIC CYSTIC NEOPLASMS AND CANCER


• Examine the diagnostic and/or prognostic value of pancreatic and blood biomarkers for pancreatic cancer;

• Understand the aggressive phenotype of Cathepsin D overexpression in pancreatic cancer;

• Discuss the rarity of cancers and high grade lesions in branch duct IPMNs and the optimal use of resources for performing surveillance imaging of pancreatic cysts; and

• Highlight how immunosuppression and cyst growth impact IPMN outcomes.

8:00 Keynote: Optimal Utilization of Resources for

Sp145 Screening of Pancreatic Cysts

Paul Moayyedi

8:20

#41

Cathepsin D Expression in Pancreatic Ductal

Adenocarcinoma (PDAC) Cells Increases

Proliferation and Reduces Survival of

Pancreatic Cancer Patients

Ujjwal M. Mahajan*, Enno Langhoff, Eithne

Costello, William Greenhalf, Christopher

Halloran, Theresa Schwaiger, Frank-Ulrich

Weiss, John Neoptolemos, Markus W. Buchler,

Markus M. Lerch, Julia Mayerle

8:34

#42

8:48

#43

Effect of Immunosuppressive Therapies on

Mucinous Pancreatic Cyst Progression

Amol Agarwal, Frank I. Scott IV, Nuzhat A.

Ahmad, Vinay Chandrasekhara*

Long-Term Outcomes of IPMNs With

Consensus Guidelines Criteria for Resection

Undergoing Nonoperative Management

Stefano Crippa*, Giovanni Marchegiani,

Giuseppe Malleo, Roberto Salvia, Claudio Bassi,

Stefano Partelli, Philippe Levy, Vinciane

Rebours, Peter A. Banks, Shadeah L. Suleiman,

Vivek Kadiyala, Nazir Ahmed, Suresh T. Chari,

Carlos Fernandez-del Castillo, Massimo Falconi

9:02

#44

9:16

#45

Elevated Neutrophil-Lymphocyte Ratio at

Diagnosis Is Associated With Worse

Nutritional Status and Survival, Irrespective of Stage in Pancreatic Cancer

Matteo Piciucchi*, Serena Stigliano, Livia

Archibugi, Giulia Zerboni, Roberto Valente Dr.,

Gianfranco Delle Fave, Gabriele Capurso

Rapid Growth Rates of Suspected Pancreatic

Cyst Branch Duct Intraductal Papillary

Mucinous Neoplasms Predict Malignancy

Wilson Kwong*, Robert D. Lawson, Syed M

Abbas fehmi, Thomas J. Savides

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8:00 AM - 9:30 AM

Room: 151B, WCC

Chairs: Frank A. Sinicrope, David H. Wang

Sponsored by: Gastrointestinal Oncology

THERAPY FOR GI CANCERS: TRANSLATIONAL

AND TARGETED APPROACHES


• Learn basic mechanisms for translational and targeted therapies for GI cancers.

8:00

#46

Aurora Kinase-A Mediates Acquired

Resistance to Everolimus in Upper

Gastrointestinal Cancers

Ahmed M. Katsha*, Janet Arras, Abbes Belkhiri,

Wael El-Rifai

8:15

#47

8:30

#48

Terpinen-4-ol: A Novel and Promising

Therapeutic Agent for Human Colorectal

Cancer

Shiran Shapira, Shlomo Pelban, Nadir Arber*

Synthetic Lethal Interaction Between

Oncogenic KRAS and Mitochondrial

Glutamate Transporter SLC25A22 Unveils a

Novel Therapeutic Target in KRAS-Mutant

Colon Cancer

Chi Chun Wong*, Yun Qian, Liuyang Zhao, Wei

Kang, Ka Fai To, Joseph J. Y. Sung, Jun Yu

8:45

#49

9:00

#50

9:15

#51

Reversal of Mutant KRAS-Mediated Apoptosis

Resistance by Concurrent Bcl-xL Antagonism and Induction of Pro-Apoptotic BH3-Only

Proteins in Colorectal Carcinoma Cells

Koichi Okamoto*, Hisato Kawakami, Shengbing

Huang, Frank A. Sinicrope

MicroRNA-31-5p As a New Biomarker for Anti-

EGFR Therapy and a Therapeutic Target in

Patients With Colorectal Cancer

Katsuhiko Nosho*, Kei Mitsuhashi, Hisayoshi

Igarashi, Hiroyuki Okuda, Hiroyoshi Kurihara,

Miki Ito, Shinichi Kanno, Yasushi Adachi, Shinji

Yoshii, Yasutaka Sukawa, Reo Maruyama,

Hiromu Suzuki, Kohzoh Imai, Kenji Okita, Koichi

Hirata, Hiroyuki Yamamoto, Yasuhisa

Shinomura

Targeted Photodynamic Nanoconjugate

Therapy for Colon Cancer

Tamara Koritarov*, Vesta Valuckaite, Reba

Mustafi, Urszula Dougherty, Irving Waxman,

Marc Bissonnette, Tijana Rajh, Vani J. Konda

AGA State-of-the-Art Lecture (2065)

10:00 AM - 11:00 AM

Room: 152, WCC

Chairs: Scott Tenner, Jeremy Wilson

Sponsored by: Pancreatic Disorders

ACUTE AND CHRONIC PANCREATITIS:

LANDMARK STUDIES, MANAGEMENT DECISIONS

AND THE FUTURE


• Review landmark studies in the field of clinical acute and chronic pancreatitis;

• Describe key questions for which evidence supports management decisions in acute and chronic pancreatitis; and

• Propose the way forward with future investigation.

10:00 Acute Pancreatitis

Sp146 Peter A. Banks

10:25

Sp147

10:50

Chronic Pancreatitis

Eugene P. DiMagno

Panel Discussion

DDW Combined Clinical Symposium (2070)

10:00 AM - 11:30 AM

Room: Ballroom C, WCC

Chairs: Mandeep Sawhney, Neena S. Abraham,

Matthew M. Hutter

Sponsored by: ASGE; AGA; SSAT

PERIPROCEDURAL MANAGEMENT OF

ANTITHROMBOTIC AGENTS


• Understand the pharmacology and clinical impact of new antiplatelet and antithrombotic agents;

• Understand the management of antiplatelet and antithrombotic agents in patients undergoing invasive procedures;

• Understand the management of severe bleeding in patients who are on antiplatelet and antithrombotic agents; and

• Understand the management of patients with liver disease induced coagulopathy.

10:00 What You Need to Know About the

Sp148 Pharmacology and Clinical Impact of New

Antiplatelet and Antithrombotic Agents

Neena S. Abraham

10:22 Management of Agents in the High Risk

Sp149 Patient Undergoing an Invasive Procedure:

When to Stop and When to Resume

Todd H. Baron

10:44 Massive Bleeding in the Post-Procedure

Sp150 Patient: When to Wait, When to "Reverse"

(and How)

James Aisenberg

11:06

Sp151

Management of the Patient With Liver

Disease and Coagulopathy

Patrick S. Kamath

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AGA Committee Sponsored Symposium (2075)

10:00 AM - 11:30 AM

Room: 158, WCC

Chair: Andrew T. Chan

Sponsored by: Research Policy Committee; Immunology,

Microbiology & Inflammatory Bowel Diseases;

Gastrointestinal Oncology

LEVERAGING BIG DATA IN GI RESEARCH


• Identify and negotiate available resources for working with big data in both clinical and basic research settings; and

• Develop strategies for working with big data in both clinical and basic research settings.

10:00 Strategies for Analysis of Big Datasets

Sp152 Curtis Huttenhower

10:30 Establishing Effective Collaborations in Big

Sp153 Data Research

Judy H. Cho

11:00 Pathways for Training in Big Data

Sp154 Mark J. Daly


10:00 AM - 11:30 AM

Room: 154, WCC

Chairs: Jason C. Mills, Linda C. Samuelson


Molecular Biology; Intestinal Disorders; Growth,


PLASTICITY OF DIFFERENTIATED GI CELLS IN

CHOICE OF CELL FATE AND DEVELOPMENT OF

TUMORS


• Appreciate how intestinal cancer arises from cells that acquire stem cell-like properties; and

• Realize the importance of the inflammatory environment in promoting tumor invasion.

10:00 Chief Cell Transdifferentiation: Pathway to

Sp158 Mucosal Repair or Pre-Cancerous Metaplasia

James R. Goldenring

10:30 Plasticity During Pancreas Differentiation and

Sp159 Tumorigenesis

Matthias Hebrok

11:00 Inflammation and Re-Acquisition of Stem Cell

Sp160 Properties in Intestinal Tumorigenesis

Florian R. Greten


10:00 AM - 11:30 AM

Room: 150B, WCC

Chairs: Dennis Black, Sandeep K. Gupta



NUTRITION, EPIGENETICS AND METABOLIC

IMPRINTING


• Understand the role of early environmental and nutritional exposures in epigenetic alteration and metabolic imprinting.

10:00 Early Environmental Influences on Intestinal

Sp155 Developmental Epigenetics

Lanlan Shen

10:30

Sp156

Influence of Early Life Nutrition on Future

Energy Balance

Karen Peterson

11:00 Environmental Exposure and Epigenetics of

Sp157 Metabolic Syndrome

Ann Scheimann


10:00 AM - 11:30 AM

Room: 150A, WCC

Chairs: Wael El-Rifai, Adrianne Theiss

Sponsored by: Gastrointestinal Oncology; Pancreatic

Disorders

RAS IS BACK: NOVEL APPROACHES AND

INSIGHTS INTO RAS AND GASTROINTESTINAL

CANCER

Participants will be able to describe the known contributions of:

• Understand the role of RAS signaling in promoting and sustaining GI cancers; and

• Appreciate the vast RAS signaling network.

10:00

Sp161

RASness, Response to Therapies and GI

Cancers

Justin Guinney

10:30 Stimulating Oncogenic RAS: Role of Diet

Sp162 Craig D. Logsdon

11:00 RAS Activation and p53 Inactivation:

Sp163 Integrative Analysis of Signaling Networks

Giulio F. Draetta


10:00 AM - 11:30 AM

Room: 102B, WCC

Chairs: Gregory G. Ginsberg, Roy M. Soetikno

THE NEW FRONTIER OF SUBMUCOSAL

ENDOSCOPY

10:00 ESD: Indications, Techniques, and Outcomes

Sp164 Norio Fukami

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10:15

Sp165

POEM: The New Standard of Care for

Achalasia?

Peter V. Draganov

10:30 Submucosal Tunneling Endoscopic Resection

Sp166 (STER):When and How

Stavros N. Stavropoulos

10:45

Sp167

The Future of Submucosal Endoscopy:

Applications, Training and Challenges

Christopher J. Gostout

11:00

#56

11:15

Sp168

Evaluation of TP53 Mutations on Barrett's

Epithelium FFPE Specimens With a Novel

Next Generation Sequencing Platform

Highlights a Discordance With p53

Immunohistochemistry: Analysis of the

Barrett's Epithelium Genome Investigation

Study (BEGINS)

Mohammed A. Butt*, Saif Khan, Rehan J.

Haidry, Michael Gandy, Ignazio Puccio,

Dahmane Oukrif, Eleanor S. Bloom, Matthew R.

Banks, Manuel Rodriguez-Justo, Marco Novelli,

Rifat Hamoudi, Laurence Lovat

State-of-the-Art Lecture: Barrett's: Diagnosis and Management - Where Are We?

Prateek Sharma


10:00 AM - 11:30 AM

Room: 101, WCC

Chairs: Lauren B. Gerson, Amitabh Chak

Sponsored by: Esophageal, Gastric & Duodenal Disorders;

Imaging & Advanced Technology; Clinical Practice;


BARRETT'S: DIAGNOSIS AND MANAGEMENT


• Discuss the latest data on Barrett's diagnosis and management; and

• Evaluate the optimal treatment approach for patients with Barrett's esophagus.

10:00

#52

Persistent Low-Grade Dysplasia in Barrett's

Esophagus Identifies Patients At Higher Risk for Esophageal Adenocarcinoma: A Dutch

Nationwide Cohort Study

Christine Kestens*, Johan Offerhaus, Jantine W.

van Baal, Peter D. Siersema

10:15

#53

10:30

#54

10:45

#55

Six Year Disease Durability Outcomes on

Patients Treated With Endoscopic Therapy for

Barrett's Related Neoplasia From the UK

Registry

Rehan J. Haidry*, Gideon Lipman, Mohammed

A. Butt, Abhinav Gupta, Rami Sweis, Jason M.

Dunn, Howard Smart, Pradeep Bhandari,

Robert P. Willert, Grant Fullarton, Jonathon

Morris, Massimiliano di Pietro, Charles Gordon,

Ian D. Penman, Hugh Barr, Philip C. Boger, Neil

Kapoor, Brinder S. Mahon, Jonathan M. Hoare,

Narayanasamy Ravi, Dermot O'Toole, Yeng

Ang, Manuel Rodriguez-Justo, Marco Novelli,

Matthew R. Banks, Laurence Lovat

Evaluation of a Minimally-Invasive

Cytosponge Esophageal Cell Collection

System in Patients With Barrett's Esophagus

Pierre Lao-Sirieix*, Irene Debiram -Beecham,

Kerr Sarah, Lisa Gadeke, Alias Bincy, Maria

O'Donovan, Marco Novelli, David Poller, Philip

Kaye, Sebastian S. Zeki, Jan Bornschein,

Massimiliano di Pietro, Sarmed S. Sami, Rehan

J. Haidry, Krish Ragunath, Pradeep Bhandari,

Laurence Lovat, Rebecca C. Fitzgerald

Detection of Barrett's Dysplasia by Assay of

Methylated DNA Markers on Whole

Esophageal Brushings: A Prospective

Feasibility Study

Prasad G. Iyer*, William R. Taylor, Tracy C. Yab,

Michele L. Johnson, Julie A. Simonson, Douglas

W. Mahoney, John B. Kisiel, David A. Katzka,

Thomas C. Smyrk, Graham P. Lidgard, David A.

Ahlquist


10:00 AM - 11:30 AM

Room: 140, WCC

Chairs: Stephen J. Meltzer, David A. Ahlquist

Sponsored by: Gastrointestinal Oncology; Esophageal,

Gastric & Duodenal Disorders; Pancreatic Disorders;

Imaging & Advanced Technology

BIOMARKERS FOR DETECTION, TREATMENT AND

PROGNOSIS OF GI CANCERS


• Describe novel biomarkers for gastrointestinal cancer.

10:00

#57

SNORA42 - An Oncogenic Small Nucleolar

RNA, and a Promising Prognostic Biomarker in Human Colorectal Cancer

Yoshinaga Okugawa*, Yuji Toiyama, Shusuke

Toden, Hiroki Mitoma, Koji Tanaka, Yasuhiro

Inoue, Masato Kusunoki, C. R. Boland, Ajay

Goel

10:18

#58

10:36

#59

Mutational Analysis of Circulating Tumor Cell

Subpopulations From Colorectal Cancer

Patients and Correlation With Primary Tumor

Tissue

Maria Gazouli*, Anna Lyberopoulou, Penelope

Bouziotis, Apostolos Papalois, Nikolaos I.

Nikiteas, Evangelos Marinos, Efstathios

Efstathopoulos

Nanoarray Sensor Technology-Based Volatile

Marker Tests to Detect Colorectal Cancer and

Colonic Adenomas

Marcis Leja*, Haitham Amal, Konrads Funka,

Aigars Vanags, Ilze Kikuste, Armands Sivins,

Ieva Lasina, Ivars Tolmanis, Limas Kupcinskas,

Hossam Haick

10:54

#60

11:12

#61

A Short Isoform of DCLK1 Is a Novel

Prognostic Marker for Human Colon Cancers, and Can Be Used As a Specific Target for

Preventing and/or Treating Colon Cancers,

While Sparing Normal Cells

Malaney R. O'Connell*, Shubhashish Sarkar,

Gurinder Luthra, Yoshinaga Okugawa, Yuji

Toiyama, Ajay Goel, Aakash Gajjar, Suimin Qiu,

Lawrence Sowers, Pomila Singh

Urinary ADAM12 and MMP-9/NGAL Complex

Detect the Presence of Gastric Cancer

Takaya Shimura*, Adelle Dagher, Monisha

Sachdev, Masahide Ebi, Tamaki Yamada,

Tomonori Yamada, Takashi Joh, Marsha A.

Moses

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10:00 AM - 11:30 AM

Room: 145A, WCC

Chairs: James Galligan, Gary M. Mawe

Sponsored by: Neurogastroenterology & Motility;

Esophageal, Gastric & Duodenal Disorders

EMERGING PARADIGMS IN PATHOGENESIS OF

MOTILITY DISORDERS


• Learn about macrophages, and their role in immune regulation and control of neural and motor behavior.

10:00

#62

TNF a

Derived From Conventionally-Activated

M1 Macrophages Inhibits Survival of Mouse

Interstitial Cells of Cajal

Seth T. Eisenman*, Simon J. Gibbons, Pieter-

Jan Verhulst, Gianrico Farrugia

10:15

#63

10:30

#64

Gliomodulation of Neuronal and Motor

Behavior in the Human GI Tract

Andromeda Linan Rico, Iveta Grants, Bradley J.

Needleman, Kent C. Williams, Suren

Soghomonyan, Fabio Turco, Rosario Cuomo,

John R. Grider, Derek M. Kendig, K. S. Murthy,

Alan Harzman, Fernando Ochoa-Cortes, Fievos

L. Christofi*

Age-Related Shift in Macrophage Polarization

Causes Inflammation in ENS

Microenvironment

Laren Becker*, Aida Habtezion

10:45

#65

11:00

#66

Role of ANO1 in Slow Wave and Tone

Generation in the Internal Anal Sphincter

Caroline A. Cobine*, Emily E. Hannah,

Alexandra G. Sotherton, Ileah Kirchoff, Sean M.

Ward, Kathleen D. Keef

Diabetic CSF OP/Op (Op/Op) Mice Lacking

Functional Macrophage Colony Stimulating

Factor (CSF1) Develop Delayed Gastric

Emptying and Depleted Networks of

Interstitial Cells of Cajal When Treated With

Recombinant CSF1

Gianluca Cipriani*, Simon J. Gibbons,

Stephanie S. Hein, Seth T. Eisenman, Gary J.

Stoltz, David R. Linden, Joseph H. Szurszewski,

Gianrico Farrugia

11:15 Molecular Control Mechanisms of Intestinal

Sp169 Smooth Muscle Cells and Sphincters

Satish C. Rattan


10:00 AM - 11:30 AM

Room: 156, WCC

Chairs: V.K. Viswanathan, Blair B. Madison

Sponsored by: Intestinal Disorders; Growth,


INJURY MODELS/STEM CELLS





10:00

#67

Krüppel-Like Factor 4 Modulates the

Proliferation and Survival of Bmi1 + Stem Cell

Derived Crypts in the Intestine Following g

-

Radiation-Induced Gut Injury in Mice

Jes G. Kuruvilla*, Agnieszka Bialkowska, Amr

Ghaleb, Vincent W. Yang

10:15

#68

10:30

#69

Mechanisms Underlying Probiotic Bacteria

Induced Increase in Intestinal Epithelial

Secretory Cells

Ishita Chatterjee*, Anoop Kumar, Shubha

Priyamvada, Alip Borthakur, Ravinder K. Gill,

Waddah A. Alrefai, Pradeep K. Dudeja

Metabolites of Lactobacillus rhamnosus GG

Prevent IFNgamma-Induced Disruption of

Mucosal Tight Junction in Mice Enteroid

Xu Han*, Jun Gao, Sha Huang, Jason Spence,

Chung Owyang

10:45

#70

11:00

#71

11:15

#72

The Role of Paneth Cells in the Maintenance of Intestinal Microbial Homeostasis

Andrew B. Shreiner*, Merritt Gillilland III,

Michael Rajala, Mohamad El-Zaatari, Helmut

Grasberger, Min Zhang, Linda C. Samuelson,

Nobuhiko Kamada, John Y. Kao

Activation of NLRP3 Inflammasome Increases

Intestinal Epithelial Permeability In Vitro

Jacob Kurowski*, Fangyi Liu, Peng Wang,

Heng-Fu Bu, Hua Geng, Xiao Wang, Suhail

Akhtar, Xiao-Di Tan

Regulation by miR-195 of Actin-Related

Protein-2 Translation Modulates Gut Epithelial

Restitution After Wounding

Navneeta Rathor*, Lan Xiao, Pornima Phatak,

Tongtong Zou, Lan Liu, Jian-Ying Wang, Rao N.

Jaladanki

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10:00 AM - 11:30 AM

Room: 149AB, WCC

Chairs: Yehuda Ringel, Michel Neunlist


MICROBIOTA, METABOLITES AND MOTILITY


• Learn about cutting-edge research that advances our knowledge of the enteric microflora and its role in neurogastroenterological disorders.

10:00

#73

Adrenergic Innervation Regulates Intestinal

Microbiota Diversity and Richness via

Cholinergic Th17 Lymphocytes

Shobhit Dhawan, Giada De Palma, Rose

Willemze, Jose Duarte, Francisca Hilbers, Elena

F. Verdu, Premysl Bercik, Wouter de Jonge*

10:15

#74

10:30

#75

Fecal Metabolites Associated With Nitrergic

Myenteric Neuronal Impairment and

Gastrointestinal Motility Disorders in Western

Diet-Fed Mice

Francois Reichardt*, Sahar Tabatabavakili,

Behtash G. Nezami, Benoit Chassaing, Amar B.

Mandalia, Andrew T. Gewirtz, Dean Jones,

Shanthi Srinivasan

In Combat Soldiers Resting Urinary

Metabotypes Correlate With the Development of Gastrointestinal Symptoms During Stress

Lee Cheng Phua, Clive H. Wilder-Smith,

Reuben K. Wong*, Gopalakrishnan Venkatesan,

Eric Chun Yong Chan

10:45

#76

11:00

#77

Clostridium difficile Toxin and Microbial-

Derived GABA Signals Converge to

Hyperexcite Myenteric Intrinsic Sensory

Neurons

Katerina Koussoulas*, Rachel Gwynne, Jaime

Pei Pei Foong, Cana Ross, Tor Savidge, Joel C.

Bornstein

Colonic Microbes Contributing to Hydrogen

Generation and Utilization Correlate With

Breath Methane and Functional Symptoms in

Patients With Chronic Constipation and

Constipation Predominant Irritable Bowel

Syndrome

Patricia G. Wolf*, Nicholas Chia, H. Rex

Gaskins, Adil E. Bharucha

11:15 From Metabolites to Neurotransmitters -

Sp170 What Do Your Gut Bacteria Really Do for

Motility?

Tor Savidge


10:00 AM - 11:30 AM

Room: 147, WCC

Chairs: Peter L. Lakatos, Siew C. Ng



NATURAL HISTORY OF INFLAMMATORY BOWEL

DISEASE


• Characterize the prevalence and titer of antimicrobial serologies prior to diagnosis among Crohn's disease patients with and without intestinal complications;

• Assess the prevalence and clinical outcomes among elderly-onset Chinese ulcerative colitis patients to the non-elderly in a population-based cohort; and

• Compare the evolution of Crohn's disease behavior in a

Dutch population-based cohort in the pre-biologic and the biologic eras.

10:00

#78

10:15

#79

Longitudinal Status of Serological Markers

Predict Crohn's Disease Phenotype Before

Diagnosis: A ‘PREDICTS' Study

Rok Seon Choung*, Thomas P. Stockfisch, Fred

Princen, Alexander C. Maue, Bénédicte De

Vroey, Chad K. Porter, Sharat Singh, Francisco

Leon, Mark S. Riddle, Joseph A. Murray, Jean-

Frederic Colombel

Disease Behavior in Crohn's Disease Patients

Diagnosed in the Biological Era - A Dutch

Population-Based IBD-SL Cohort Study

Steven Jeuring*, Tim Van den Heuvel, Maurice

Zeegers, Wim Hameeteman, Mariëlle Romberg-

Camps, Liekele E. Oostenbrug, Ad Masclee,

Daisy Jonkers, Marie J. Pierik

10:30

#80

10:45

#81

11:00

#82

Hospitalization and Surgery Risk in Crohn's

Disease in the Biological Era - Results From the Dutch Population-Based IBD-SL Cohort

Steven Jeuring*, Tim Van den Heuvel, Maurice

Zeegers, Wim Hameeteman, Mariëlle Romberg-

Camps, Liekele E. Oostenbrug, Stephanie

Breukink, Laurents P. Stassen, Ad Masclee,

Daisy Jonkers, Marie J. Pierik

Natural History of Elderly-Onset Ulcerative

Colitis in Chinese: A Population-Based Cohort

Study

Hai Yun Shi*, Siew C Ng, Wai K. Leung, Michael

K. Li, Chi Man Leung, Shun Fung Sze, Jessica

Ching, Tiffany ML Chung, Catherine YY Iu, Fu

Hang Lo, Steve Tsang, Edwin Hok Shing Shan,

Lai Yee Mak, Belsy Chung Yan Lam, Aric J. Hui,

Sai Ho Wong, Marc Tin Long Wong, Ivan Fan

Ngai Hung, Yee Tak HUI, Yiu Kay Chan, Kam

Hon Chan, Ching Kong Loo, Raymond Wai

Hung Tong, Wai Hung Chow, Carmen Ka Man

Ng, Wai Cheung Lao, Marcus Harbord, Justin C.

Wu, Joseph J. Y. Sung, Francis K. L. Chan

Effects of Early Concomitant

Immunomodulator Exposure on Outcomes

Among Anti-TNF Users: A Population Based

Analysis

Laura Targownik*, Aruni Tennakoon, Harminder

Singh, Zoann Nugent, Lisa Lix, Charles N.

Bernstein

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#83


Biological Therapy Is Able to Modify the

Disease Progression of Crohn's Disease

Preventing Its Long-Term Associated

Disability - A Study Performed by Using the

LèMann Score

Giorgia Bodini*, Vincenzo Savarino, Costanza L.

De Maria, Layla Yehia, Isabella Baldissarro,

Edoardo Savarino


10:00 AM - 11:30 AM

Room: 159, WCC

Chairs: Naji Abumrad, Efi Kokkotou


Regulatory Peptides, Cell Signaling & Molecular Biology;

Esophageal, Gastric & Duodenal Disorders;


NEUROENDOCRINE REGULATION OF FOOD

INTAKE AND ENERGY EXPENDITURE


• Learn how neuroendocrine circuits are involved in the regulation of nutrient intake and metabolic function in health and disease and across the life span.

10:00

#84

From Gut to Brain: A Sensory Neuroepithelial

Circuit

Diego V. Bohórquez*, Rodger A. Liddle

10:15

#85

10:30

#86

10:45

#87

Effect of Acute Exercise on Myokines and

Hormones Regulating Food Intake in

Moderate Active Human Volunteers.

Involvement of Brain-Gut and Myokine-Brain

Axes

Jan Bilski, Agnieszka I. Mazur-Bialy, Janusz

Pokorski, Jacek Nitecki, Joanna Pokorska, Ewa

Nitecka, Bartosz Brzozowski, Marcin Surmiak,

Tomasz Brzozowski*

Obese Patients Have Significantly Higher

Motilin Plasma Levels Which Decrease After

Roux-en-Y Gastric Bypass Surgery

Eveline Deloose*, Pieter Janssen, Matthias

Lannoo, Bart Van der Schueren, Inge

Depoortere, Jan F. Tack

Intraduodenal Infusion of a Combination of

Tastants Decreases Food Intake

Mark van Avesaat*, Freddy Troost, Dina Ripken,

Henk F. Hendriks, Ad Masclee

11:00

#88

11:15

#89

The Hypophagia After Psychological Stress in

Aged Male Mice Is Mediated by an Interaction of Activation of Estrogen Receptor a

With

Serotonin 2C Receptor

Shunsuke Ohnishi*, Koji Nakagawa, Naoto

Okubo, Chiharu Sadakane, Yayoi Saegusa,

Miwa Nahata, Chihiro Yamada, Tomohisa

Hattori, Naoya Sakamoto, Hiroshi Takeda

Different Response to Chronic Isolation Stress

Between Young and Aged Mice

Hiroshi Takeda*, Shunsuke Ohnishi, Koji

Nakagawa, Naoto Okubo, Chihiro Yamada,

Yayoi Saegusa, Miwa Nahata, Tomohisa Hattori,

Naoya Sakamoto


10:00 AM - 11:30 AM

Room: 145B, WCC

Chairs: Deanna D. Nguyen, Jesus Rivera-Nieves


Bowel Diseases

USING ANIMAL MODELS TO DEVELOP NOVEL

THERAPIES


• Determine how novel targets can be assessed in animal models of IBD to examine their potential role for drug development.

10:00

#90

Efficacy of a Novel Small Molecule RORgt

Inverse Agonist in Mouse DSS and TNBS

Models of Inflammatory Bowel Disease

Leo R. Fitzpatrick*, Jim Zapf, Elizabeth M.

Flood, Satheesh B. Ravula, Laura K. Lingardo,

Jeff Small, Fabio Tucci, Chris A. Buhr, Gordon

Alton

10:15

#91

10:30

#92

Losartan Abrogates Intestinal Fibrosis After

Steroid Induced Remission in Experimental

Ileitis

Shuvra Ray*, Carlo De Salvo, Loris Riccardo

Lopetuso, Wei Xin, Jude Oben, Jeremy D.

Sanderson, Theresa T. Pizarro

The P2X7 Purinergic Receptor Is a Critical

Regulator of Intestinal Inflammation and

Colitis-Associated Colorectal Cancer in Mice

Claudio Bernardazzi*, Morgana T. Castelo-

Branco, Raquel Coutinho, Beatriz Pêgo, Joao

Carlos Machado, Robson Coutinho-Silva, Heitor

S. de Souza

10:45

#93

11:00

#94

11:15

#95

PD-1 Signaling As a Potential Therapeutic

Target in Ulcerative Colitis: Studies in

Oxazolone-Induced Murine Colitis Model

Abinav Singh Dr, Yu Lin, Taslima T. Lina, Don

W. Powell, Victor E. Reyes, Irina V. Pinchuk*

A Covalent Inhibitor of ITK and RLK Inhibits

Th1 and Th17 Cell Differentiation and Prevents

Disease Manifestation in an Adoptive Transfer

Model of Colitis

Hyoung-Soo Cho, James Conley, Hyun Mu

Shin, Helena Haberstock-Debic, Kenneth A.

Brameld, Timothy D. Owens, Jens Oliver Funk,

Ronald J. Hill, Michael Bradshaw*, Leslie J.

Berg

Tl1a Deficiency, but Not Dr3 Deficiency,

Ameliorated Murine Models of Chronic Colitis:

Implications for Drug Development

Yoshitake Kanazawa*, Hong Zhang, Marie F.

Fiorino, Ariel M. Hamill, Aimee Von Arx, Hon

Wai Koon, Charalabos Pothoulakis, Janine

Bilsborough, Stephan Targan, David Q. Shih

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ASGE Topic Forum (2140)

10:00 AM - 11:30 AM

Room: 103A, WCC

Chairs: Patrick R. Pfau, Arslan Kahloon

ENDOSCOPY AND COLORECTAL CANCER

10:00

#96

10:15

#97

10:30

#98

10:45

#99

11:00

#100

11:15

#101

Bevacizumab-Based Anti-Tumoral Therapy

Does Not Increase the Risk of Bowel

Perforation in Patients With Metastatic

Obstructive Colorectal Cancer Palliated With

Self-Expanding Metallic Stents. Results of a

Prospective Study

Mario de Bellis*, Lorenzo Fuccio, Elena Di

Girolamo Dr, Leonardo Frazzoni, Valeria Vicario

Dr, Paolo Delrio Dr, Giovanni B. Rossi Dr,

Guglielmo Nasti Dr, Franco Bianco Dr, Cristina

Bucci, Andrea Belli, Daniela Rega Dr, Antonio

Avallone Dr

Endoscopic Tattooing of Early Colorectal

Carcinomas Enhances Lymph Nodes Most

Prone to Carry Tumoural Cells and Helps

Nodal Harvesting

Miriam Cuatrecasas*, Iban Aldecoa, Nuria

Planell, Maria Pellise, Leticia Moreira, Salvadora

Delgado, Dulce Momblan, Jaume Balust,

Graciela Martinez-Palli, Francesc Balaguer,

Angels Gines, Gloria Fernandez-Esparrach,

Antonio M. Lacy, Antoni Castells

Patients With an Endoscopic Resection of a

Polyp Containing Carcinoma in Situ or

Intramucosal Carcinoma Have a Higher Risk of Postcolonoscopy Colorectal Cancer

Koen Kessels*, Marloes Elferink, Martijn G. van

Oijen, Johan Offerhaus, Miangela M. Laclé,

Peter D. Siersema, Leon M. Moons

Prevalence and Etiology Factors of Interval

Colorectal Cancer: Five Years Experience in an Open Access Endoscopy Center.

Carolina Bolino*, Christian A. Sanchez, Amado

Escobar, Jean Marc Dumonceau, Cecilio L.

Cerisoli, Luis E. Caro

The Risk Factor of Lymph Node Metastasis and the Indication for Additional Surgery in

T1 Colorectal Carcinomas: A Single Center

Retrospective Study

Katsuro Ichimasa*, Shin-ei Kudo, Hideyuki

Miyachi, Yuta Kouyama, Yui J. Kimura, Shingo

Matsudaira, Hiromasa Oikawa, Masashi Misawa,

Yuichi Mori, Toyoki Kudo, Kenta Kodama,

Tomokazu Hisayuki, Kunihiko Wakamura,

Takemasa Hayashi, Atsushi Katagiri, Shigeharu

Hamatani, Eiji Hidaka, Fumio Ishida

Endoscopic Resection of High-Risk T1

Colorectal Carcinoma Prior to Surgical

Resection Has No Adverse Effect on Long-

Term Outcomes

Anouk Overwater*, Martijn G. van Oijen, Aneya

Van den Blink, Marcel Spanier, Tom Seerden,

Hendrikus J. Pullens, Wouter H. de Vos tot

Nederveen Cappel, Johan Offerhaus, DirkJan

Bac, Marjon Kerkhof, Koen Kessels, Peter D.

Siersema, Marloes Elferink, Miangela M. Laclé,

Leon M. Moons


10:00 AM - 11:30 AM

Room: 103B, WCC

Chairs: Inessa Khaykis, Udayakumar Navaneethan

PANCREAS CYST: WATCH, SAMPLE, ABLATE AND

RESECT

10:00

#102

10:15

#103

10:30

#104

10:45

#105

11:00

#106

11:15

Sp171

International Multicenter IPMN Registry: Role of EUS-FNA Cytology, CEA and Amylase in the Diagnosis of Intraductal Papillary

Mucinous Neoplasms

Maria Moris*, Massimo Raimondo, Timothy A.

Woodward, Verna Skinner, Paolo G.

Arcidiacono, Maria C. Petrone, Claudio De

Angelis, Selene F. Manfrè, Pietro Fusaroli,

Horacio J. Asbun, John Stauffer, Michael

Wallace

EUS Guided Ethanol Injection of Pancreatic

Cystic Neoplasms: Outcomes of a Prospective

Study

Victoria Gomez*, Naoki Takahashi, Andrea

Jones, Yajue Huang, Suresh T. Chari, Jonathan

E. Clain, Ferga C. Gleeson, Michael J. Levy,

Randall K. Pearson, Bret T. Petersen, Elizabeth

Rajan, Santhi Swaroop Vege, Kiaran McGee,

Mark Topazian

Is Alcohol Required for Effective Pancreatic

Cyst Ablation? The Prospective Randomized

CHARM Preliminary Trial Pilot Study

Matthew T. Moyer*, Charles E. Dye, Brooke

Ancrile, Setareh Sharzehi, Abraham Mathew,

Thomas J. McGarrity, Niraj J. Gusani, Nelson

Yee, Joyce Wong, John M. Levenick, Brandy

Dougherty-Hamod, Bradley Mathers

Malignant Progression During Long-Term

Follow-Up of Pancreatic Cysts: How Often Do

We Change Teatment Strategy?

Selma J. Lekkerkerker*, Paul Fockens, Marc

Besselink, Erik Rauws, Jeanin E. van Hooft

Management of Branched Duct Intraductal

Papillary Mucinous Neoplasms: A Large

Single Center Study to Assess Predictors of

Malignancy and Recurrence on Long Term

Follow-Up

Wiriyaporn Ridtitid*, C. Max Schmidt, John M.

DeWitt, Alexandra M. Roch, Jennifer S. Stuart,

Stuart Sherman, Mohammad A. Al-Haddad

State of the Art - Update on Management of

IPMN

Thomas J. Savides

ASGE Hands-on Workshop (HW1)

11:00 AM - 1:30 PM

Room: HALL A, WCC

Chair: Jeffrey M. Marks

ASGE HANDS-ON WORKSHOP: HEMORRHOID

THERAPIES

Sp171a Faculty

Ashley L. Faulx, Dennis M. Jensen, Sergey

Kantsevoy, David Lichtenstein, Michael F.

McGee, Eric M Pauli, Thomas J. Savides, Raj J.

Shah

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SSAT Hands-on (SSHOC1)

1:00 PM - 5:00 PM

Room: HALL A, WCC

Chair: Michael G. House

SSAT HANDS-ON SESSION, HPB: UTILIZATION OF

INTRAOPERATIVE ULTRASOUND IN HPB

SURGERY


• Describe the usefulness of ultrasound during any operative procedure (open and laparoscopic) involving the liver, pancreas or biliary tract;

• Explain the application of intraoperative ultrasound to complement preoperative radiologic imaging and to determine anatomic spatial relationships between tumors and adjacent vital structures; and

• Utilize IOUS to guide operative procedures (open and laparoscopic) of the liver, pancreas, and biliary tract

(including segmental liver resection, liver tumor biopsy, liver tumorablation or enucleation, drainage of pancreas duct, enucleation of pancreatic tumors).

1:00

3:00

Session I: 1:00-3:00

Session II: 3:00-5:00

Sp172 Open Liver Procedures

Reid Adams, Michael D'Angelica, Guido Torzilli

Sp175 Laparoscopic Liver Procedures

Thomas Aloia, David A. Geller, Michael G.

House, David A. Iannitti Sr., Michael A. Choti

Sp179 Pancreas Procedures

Syed Ahmad, Michael G. House, Henry Pitt,

Nicholas J. Zyromski


2:00 PM - 3:30 PM


Chairs: Edward V. Loftus, Najjia N. Mahmoud, David

A. Schwartz

Sponsored by: AGA; ASGE; SSAT

MULTI-DISCIPLINARY APPROACH TO PERIANAL

CROHN'S DISEASE


• Compare the operating characteristics of magnetic resonance imaging, endoscopic ultrasound, and other imaging modalities in the assessment of Crohn's disease patients with suspected perianal complications;

• Understand the role of surgery in the management of perianal Crohn's disease; and

• Estimate the effectiveness and safety of antibiotics, immunomodulators, and biologics in the treatment of perianal Crohn's disease.

2:00 Role of EUS, MRI and Other Imaging or

Sp187 Endoscopy in Perianal Crohn's

David A. Schwartz

2:30 Surgical Approaches to Perianal Crohn's

Sp188 Disease

Phillip Fleshner

3:00 Medical Management of Perianal Crohn's

Sp189 Disease

Geert R. D'Haens

SSAT Hands-on (SSHOC2)

1:00 PM - 5:00 PM

Room: HALL A, WCC

Chairs: Alessandro Fichera, Patricia Sylla

SSAT HANDS-ON SESSION, SMALL BOWEL &

COLORECTAL: TRANSANAL ENDOSCOPIC

SURGERY


• Explain the operative set up of transanal devices and equipment currently used to perform TES;

• Demonstrate how to troubleshoot technical difficulties during TES; and

• Apply technical skills in the performance of TES on all the available transanal devices.

1:00

3:00

5:00

Session I: 1:00-3:00

Session II: 3:00-5:00

5:00

TEO

Alessandro Fichera, Patricia Sylla

TAMIS

Matthew Albert, Elisabeth McLemore

AGA Clinical Symposium (2170)

2:00 PM - 3:30 PM

Room: 151B, WCC

Chairs: Pankaj J. Pasricha, Jasmine Zia


Gastrointestinal Oncology; Immunology, Microbiology &

Inflammatory Bowel Diseases

DEVELOPING TARGETED DRUG THERAPY FOR GI

DISEASE


• Learn about new targets for symptomatic relief;

• Understand the barriers to drug development in gastroenterology; and

• Listen to the perspective of big Pharma on GI disorders as a therapeutic area.

2:00 Novel High Throughput Approaches to

Sp190 Development of Anti-Diarrheals

Alan S. Verkman

2:25

Sp191

Facilitating Pathways to Patients in

Functional and Other GI Diseases: What Are the Roadblocks From a Regulatory

Perspective?

Juli Tomaino

2:46 What Scares Investors From Investing in GI

Sp192 Disorders?

Bruce Robertson

3:07 How Do We Re-Engage Pharma in GI Drug

Sp193 Development?

Gareth Hicks

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AGA GRG Spring Symposium (2175)

2:00 PM - 3:30 PM

Room: 145B, WCC

Chairs: Barbara H. Jung, John P. Lynch

Sponsored by: Gastroenterology Research Group (GRG);

Gastrointestinal Oncology; Liver & Biliary

CHIPS AHOY


• Understand the clinical potential of high content screening in the form of chips designed to query specific GI organs; and

• Learn about translational application of Chip technology to GI disease.

2:00

Sp194

2:27

Sp195

Intestine On A Chip

Nancy L. Allbritton

Microengineered Physiological Bio-Mimicry:

Human Organs-On-Chips

Dongeun "Dan" Huh

2:54 Gut Microbiome, Human Health and Rapid

Sp196 Diagnosis Chips

Syed A. Hashsham

3:21 Questions and Answers


2:00 PM - 3:30 PM

Room: 158, WCC

Chairs: Nicholas O. Davidson, Michael E. Rothenberg

Sponsored by: Intestinal Disorders; Gastrointestinal

Oncology

NEXT GENERATION SEQUENCING:

OPPORTUNITIES FOR RESEARCH AND PRACTICE


• Learn of new advances in single cell transcriptome profiling;

• Learn how the transcriptome is modified in differentiating cells; and

• Learn how advances in sequencing technology can be applied to understanding subtypes of colorectal cancer.

2:00 Single Cell PCR: Is Fluidigm the Next

Sp201 Paradigm?

Scott T. Magness

2:30 Functional Heterogeneity of T-Cell Receptors

Sp202 at the Single Cell Level

Arnold Han

3:00 Next Generation Sequencing in Colorectal

Sp203 Cancer/Polyposis Syndromes

Ian Tomlinson


2:00 PM - 3:30 PM

Room: 154, WCC

Chairs: Rohit Kohli, Mary E. Rinella

Sponsored by: Obesity, Metabolism & Nutrition; Liver &

Biliary

INTESTINAL AND HEPATIC LIPID DROPLETS IN

HEALTH AND DISEASE


• Understand the physiologic and pathologic roles of cytoplasmic lipid droplets in the enterocyte and hepatocyte; and

• Understand the potential for lipid droplets as therapeutic targets in NAFLD.

2:00

Sp197

2:22

Sp198

Mechanisms of Lipid Synthesis and Storage in

Lipid Droplets

Robert Farese

Cytoplasmic Lipid Droplet Synthesis and

Catabolism in Enterocytes

Kimberly K. Buhman

2:44 Control of Lipolysis in Lipid Droplets by

Sp199 Perilipin

Dawn L. Brasaemle

3:06 The Lipid Droplet As a Therapeutic Target in

Sp200 NAFLD

Jurgen Borlak


2:00 PM - 3:30 PM

Room: 102B, WCC

Chairs: Aurelia Lugea, Anil K. Rustgi

Sponsored by: Pancreatic Disorders; Gastrointestinal

Oncology

CLINICAL TARGETING OF STELLATE CELLS AND

AUTOPHAGY IN PANCREATIC CANCER: HOPE

FOR PATIENTS OR POTENTIAL DISASTER?


• Understand evolving clinical treatment targets for pancreatic cancer;

• Recognize the paradoxical pro- and anti-neoplastic effects of stellate cells on pancreatic cancer; and

• Review the rationale for inhibiting autophagy in pancreatic cancer and that this approach may have proand anti-neoplastic effects dependent upon stage of tumor development.

2:00 Stellate Cells Are Anti-Neoplastic

Sp204 Andrew D. Rhim

2:18 Stellate Cells Are Pro-Neoplastic

Sp205 Minoti V. Apte

2:36 Inhibiting Autophagy Is Anti-Fibrotic and

Sp206 Anti-Neoplastic

Juan L. Iovanna

2:54 Can Inhibiting Autophagy Be Pro-

Sp207 Tumorigenic?

Kevin Ryan

3:12 Panel Discussion

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2:00 PM - 3:30 PM

Room: 145A, WCC

Chairs: Gary D. Wu, Emad El-Omar


MICROBIOME, METABOLITES AND CANCER


• Understand the role of the microbiome in the production of metabolites that influence cancer risk;

• Understand potential chemopreventive opportunities by targeting microbial metabolites; and

• Understand what is the intestinal metabolome and how it functions to influence cancer risk.

2:00 Colonic Metabolites and Cancer Risk

Sp208 Stephen J. O'Keefe

2:30 Polyamines and Colon Cancer: Opportunities

Sp209 for Chemoprevention

Steven H. Erdman

3:00 The Intestinal Metabolome

Sp210 Tiffany L. Weir


2:00 PM - 3:30 PM

Room: 103A, WCC

Chairs: Kenneth Binmoeller, Manoop S. Bhutani

INTERVENTIONAL AND THERAPEUTIC EUS: YES,

IT'S HERE!

2:00

Sp211

EUS-Guided Gallbladder and Biliary Drainage:

A Technique Whose Time Has Come?

Everson L. Artifon

2:15 EUS-Guided Pancreatic Duct Access

Sp212 Takao Itoi

2:30 EUS-Guided NOTES and Creation of

Sp213 Anastamoses

Annette Fritscher-Ravens

2:45 EUS-Guided Hemostatis

Sp214 Michael J. Levy

3:00 EUS-Guided RFA of Tumors

Sp215 Dong Wan Seo

ASGE Special Session (2205)

2:00 PM - 3:30 PM

Room: 149AB, WCC

Chair: Walter Coyle

SENIOR FELLOWS UPDATE SESSION

2:00

Sp216

EMR

Mihir S. Wagh

2:15 Anorectal Disease

Sp217 Waqar A. Qureshi

2:30 "On-Call" Emergencies

Sp218 Keith L. Obstein

2:45

Sp219

Chromoendoscopy

Raquel E. Davila

3:00 Dilation

Sp220 Mohammad A. Al-Haddad

3:15 Tricks and Tips in Colonoscopy

Sp221 Walter Coyle

AGA Distinguished Abstract Plenary (2210)

2:00 PM - 3:30 PM

Room: 103B, WCC

Chairs: Juanita L. Merchant, Bernd Schnabl

Sponsored by: Intestinal Disorders

INTESTINAL DISORDERS DISTINGUISHED

ABSTRACT PLENARY






Jerrold R. Turner, MD, PhD, AGAF

2:06

#107

Results From the "GLUTOX" Trial: A

Randomised, Double Blind, Placebo

Controlled Crossover Study on "Non Celiac

Gluten Sensitivity"

Luca Elli*, Carolina Tomba, Federica Branchi,

Vincenza Lombardo, Maria Teresa Bardella,

Flavio Valiante, Lucia Fini, Edoardo Forti,

Enrico Orzes, Renato Cannizzaro, Claudio

Londoni, Nunzia Semperlotti, Giovanni

Fornaciari, Rocco Spagnuolo, Nicoletta Lenoci,

Guido Basilisco, Francesco Somalvico, Bruno

Borgatta, Dario Conte, Elisabetta Buscarini

2:20

#108

2:34

#109

2:48

#110

3:02

#111

3:16

#112

Widespread Contamination of Probiotics

With Gluten, Detected by Liquid

Chromatography-Mass Spectrometry

Samantha Nazareth*, Benjamin Lebwohl,

Jennifer Sealey Voyksner, Peter H. Green

Myosin VB Germline Knockout Mice Display

Microvillus Inclusions in Intestinal Enterocytes and Failure to Thrive

Victoria G. Weis*, Byron Knowles, Eunyoung

Choi, Anna E. Goldstein, James R. Goldenring

Missense Mutations of SLC9A3 in Patients

With Congenital Sodium Diarrhea Are

Associated With Reduced Na+/H+ Exchanger

3 (NHE3) Activity: Identification of the Cause of the Phenotype

Jianyi Yin*, Rafiquel Sarker, Jianbo Yang, Peter

Heinz-Erian, Thomas Müller, Heinz Zoller, Ming

Tse, Andreas R. Janecke, Mark Donowitz

Loss of Prohibitin in Intestinal Epithelial Cells

Triggers the Development of Spontaneous

Ileitis in Mice Subsequent to Mitochondrial

Dysfunction and Paneth Cell Defects

Jie Han, Marina Panopoulos, Bin He, Bert W.

O'Malley, Sylvie Robine, Robert M. Genta,

Rhonda F. Souza, Winston E. Thompson,

Arianne L. Theiss*

Tissue-Specific miR-222 Overexpression

Delays Intestinal Mucosal Repair by

Repressing Expression of Wnt-Receptor

Frizzled-7

Hee Kyoung Chung*, Rao N. Jaladanki,

Tongtong Zou, Lan Liu, Lan Xiao, Peixin Yang,

Jian-Ying Wang

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2:00 PM - 3:30 PM

Room: 146C, WCC

Chairs: Ikuo Hirano, Robert T. Kavitt


Neurogastroenterology & Motility; Growth, Development &

Child Health; Clinical Practice

ADVANCES IN DISEASE ASSESSMENT IN THE

TREATMENT OF EOSINOPHILIC ESOPHAGITIS


• Discuss the latest data regarding treatment options in eosinophilic esophagitis.

2:00

#113

Randomized, Double-Blind, Placebo

Controlled Trial Demonstrates the Efficacy of

Oral Budesonide Suspension in Improving

Endoscopically Identified Esophageal

Abnormalities in Eosinophilic Esophagitis

Ikuo Hirano*, David A. Katzka, Margaret H.

Collins, Evan S. Dellon

2:15

#114

2:30

#115

A Multicenter Study Assessing the Clinical,

Endoscopic and Histologic Response to Four

Food Elimination Diet for the Treatment of

Eosinophilic Esophagitis

Amir Kagalwalla*, Katie Amsden, Melanie M.

Makhija, Joshua B. Wechsler, Anthony Olive,

Sally Schwartz, Carla M. Davis, Kristin Johnson,

Marion Groetch, Mary Ellen Riffle, Maria

Manuel-Rubio, Hector Melin-Aldana, Barry K.

Wershil, Margaret H. Collins, Mirna Chehade

Predicting Endoscopic and Histologic

Remission in Adult Patients With Eosinophilic

Esophagitis Using the EEsAI PRO Score

Ekaterina Safroneeva*, Michael Coslovsky,

Radoslaw Panczak, Marcel Zwahlen, Claudia

Kuehni, Nadine Haas, Jeffrey A. Alexander,

Evan S. Dellon, Nirmala Gonsalves, Ikuo Hirano,

John Leung, Christian Bussmann, Margaret H.

Collins, Robert Newbury, Giovanni DePetris,

Thomas C. Smyrk, John T. Woosley, Guang-Yu

Yang, Yvonne Romero, David A. Katzka, Glenn

Furuta, Sandeep K. Gupta, Seema Aceves,

Mirna Chehade, Alex Straumann, Alain

Schoepfer

2:45

#116

3:00

#117

Swallowed Fluticasone Is an Effective and

Safe Long-Term Maintenance Therapy in

Children With Eosinophilic Esophagitis

Doerthe A. Andreae*, Matthew G. Hanna,

Margret Magid, Emilia Bagiella, Stefano

Malerba, Mirna Chehade

Correlation of Histology to Endoscopic

Mucosal Impedance in Patients With


Karthik Ravi*, David A. Katzka, Debra M. Geno,

Thomas C. Smyrk, Prasad G. Iyer, Jeffrey A.

Alexander, Jerry Mabary, Michael Camilleri,

Michael F. Vaezi

3:15 State-of-the-Art: Therapy of EoE in 2015

Sp222 David A. Katzka


2:00 PM - 3:30 PM

Room: 150A, WCC

Chairs: Gary W. Falk, Rhonda F. Souza


Imaging & Advanced Technology; Clinical Practice;


BARRETT'S ESOPHAGUS: FROM PATHOGENESIS

TO SURVEILLANCE


• Discuss the latest research in the field of pathogenesis and surveillance of Barrett's esophagus.

2:00

#118

Identification of a Novel Germ-Line Variant in an Uncharacterized Gene, FBE-1, and Its

Putative Role in Familial Barrett's Esophagus

Ryan E. Fecteau*, Kishore Guda, Sanford

Markowitz, Joseph Willis, John P. Lynch,

Jianping Kong, Robert Elston, Wendy Brock,

Amitabh Chak

2:15

#119

2:30

#120

Gastroesophageal Reflux Modifies the Risk of

Barrett's Esophagus Associated With the

Metabolic Effects of Obesity

Bradley J. Kendall*, Graeme A. Macdonald,

Johannes Prins, Suzanne O'Brien, Aaron P.

Thrift, David C. Whiteman

Risk of Malignant Progression in Barrett's

Esophagus Indefinite for Dysplasia

Michelle Ma*, Ann Tierney, Stuti Shroff, Michael

D. Feldman, Maureen DeMarshall, Carly S.

Price, Gary W. Falk

2:45

#121

3:00

#122

Detection of Dysplasia Arising in Barrett's

Esophagus Is Improved by Trained

Endoscopists With a Specialist Interest on

Dedicated Lists

Jason M. Dunn*, Giles Walker, Joanne L. Ooi,

Sabina De Martino, John O'Donohue Dr., David

Reffitt, John Meenan

Novel Blood Based Biomarkers in the Risk

Stratification of Patients With Reflux Disease

Hasan N. Haboubi*, Joan Churu, Benjamin

Rees, Lisa Williams Dr, James M. Manson,

Catherine Thornton, George E. Johnson,

Gareth Jenkins

3:15 State-of-the-Art Lecture: Barrett's: How Does

Sp223 It Form and How Do We Follow Patients

Stuart J. Spechler

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2:00 PM - 3:30 PM

Room: 150B, WCC

Chairs: Scott B. Snapper, Lee Denson


Bowel Diseases

IBD: INNATE AND ADAPTIVE IMMUNE FUNCTION


• Understand the contribution of components of the innate and adaptive immune response to intestinal inflammation and the mucosal barrier.

2:00

#123

A Macrophage Intrinsic Role of WASP Is

Critical for Maintenance of Mucosal

Homeostasis

Amlan Biswas*, Dror S. Shouval, Jeremy A.

Goettel, Scott B. Snapper

2:15

#124

2:30

#125

Core Fucosylation Regulates T-Cell Activation and Ameliorates Murine Colitis

Hironobu Fujii*, Shinichiro Shinzaki, Hideki

Lijima, Kana Wakamatsu, Chizuru Iwamoto,

Shinji Takamatsu, Yoshihiro Kamada, Masahiko

Tsujii, Tetsuo Takehara, Eiji Miyoshi

Protein Tyrosine Phosphatase Non-Receptor

Type 22 Dephosphorylates NLRP3 to Enable

Efficient Inflammasome Activation

Marianne R. Spalinger*, Stephanie Kasper,

Claudia Gottier, Isabelle Frey-Wagner, Silvia

Lang, Kirstin Atrott, Stephan R. Vavricka, Hans-

Dietmar Beer, Andrew C. Chan, Michael Fried,

Gerhard Rogler, Michael Scharl

2:45

#126

3:00

#127

3:15

#128

Intestinal Epithelial Dual Oxidase 2

Expression Induced by Gut Dysbiosis

Regulates Commensal-Mucosal Homeostasis by Restricting Bacterial Translocation in the

Small Intestine

Helmut Grasberger*, Jun Gao, Kathryn A.

Eaton, Hiroko Kitamoto, Sho Kitamoto, Min

Zhang, Nobuhiko Kamada, Mohamad El-

Zaatari, Andrew B. Shreiner, Juanita L.

Merchant, Chung Owyang, John Y. Kao

Histamine Drives Innate Inflammation in

Ulcerative Colitis

Joshua B. Wechsler*, Terrence A. Barrett, Paul

Bryce

Signaling Crosstalk Between TGFb

/Notch on

Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and

Luminal Microbiota

Sozaburo Ihara*, Yoshihiro Hirata, Takako

Serizawa, Nobumi Suzuki, Hiroto Kinoshita,

Hayato Nakagawa, Hideaki Ijichi, Kazuhiko

Koike


2:00 PM - 3:30 PM

Room: 146AB, WCC

Chairs: Sushovan Guha, Yusuke Mizukami

Sponsored by: Gastrointestinal Oncology; Pancreatic

Disorders

INFLAMMATION, TUMOR MICROENVIRONMENT

AND PANCREATIC CARCINOGENESIS


• Understand the role of inflammation and tumor microenvironment in the pathogenesis of pancreatic cancer.

2:00

#129

The Transcriptional Activity of GLI in

Pancreatic Ductal Adenocarcinoma Is

Mediated by Interaction With the BET Family of Chromatin Adaptors

Yinshi Huang*, Curtis E. Adams, Keith Lillemoe,

Carlos Fernandez-del Castillo, Andrew L.

Warshaw, Andrew S. Liss

2:15

#130

2:30

#131

DCLK1 Regulates COX-2 via miR-144 microRNA-Dependent Mechanism

Sripathi M. Sureban*, Dongfeng Qu, Randal

May, Nathaniel Weygant, Parthasarathy

Chandrakesan, Naushad Ali, Courtney W.

Houchen

PEDF Opposes Pancreatic Tumorigenesis by

Affecting Tumor-Associated Inflammation and

Fibrosis

Daniel R. Principe, Brian DeCant, Andrew M.

Diaz, Riley J. Mangan, Elizabeth A. Wayne,

David J. Bentrem, Hidayatullah G. Munshi,

Barbara H. Jung, Paul Grippo, Faraz Bishehsari*

2:45

#132

3:00

#133

3:15

#134

Attenuation of Pancreatic Cancer Metastasis

Through Specific Inhibition of the RAC

Activator Vav1

Gina L. Razidlo*, Christopher Magnine, Arthur

C. Sletten, Rachel M. Hurley, Martin E.

Fernandez-Zapico, Baoan Ji, Mark A. McNiven

Sensory Denervation Decreases PanIN

Progression in a Mouse Model of Pancreatic

Cancer

Smrita Sinha*, Ya-Yuan Fu, Maren Ketcham,

Gordon J. Hildick-Smith, Kelly J. Lafaro, Joseph

Saglimbeni, Olivera Grbovic-Huezo, Lecomte

Nicolas, Jerry Melchor, Robert C. Kurtz, Steven

Leach, Pankaj J. Pasricha

Stress Accelerates Pancreatic Carcinogenesis

Through Beta-2 Adrenergic Signaling

Bernhard W. Renz*, Marina Macchini, Yoku

Hayakawa, Christoph B. Westphalen, Michael

Churchill, Shradha S. Khurana, Suchetak Kar,

Xiaowei Chen, Yagnesh H. Tailor, Axel

Kleespies, Jens Werner, Daniel L. Worthley,

Alina C. Iuga, Kenneth P. Olive, Timothy C.

Wang

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2:00 PM - 3:30 PM

Room: 101, WCC

Chairs: Jayant A. Talwalkar, Ariel E. Feldstein

Sponsored by: Liver & Biliary; Gastrointestinal Oncology

METABOLIC AND GENETIC LIVER DISEASE (I)


• Identify predictors and markers of outcomes in NASH; and

• Describe new treatment modalities that may modulate hepatic steatosis and its mediators.

2:00

#135

MicroRNAs Explain the Discordance of

Nonalcoholic Fatty Liver Disease in

Monozygotic and Dizygotic Twins: A

Prospective Human Twin Study

Amir Zarrinpar*, Shakti Gupta, Mano R. Maurya,

Shankar Subramaniam, Rohit Loomba

2:15

#136

2:30

#137

Attenuation of Hepatic Steatosis in Mice

Using Specific Monoclonal Antibodies to

Gastric Inhibitory Polypeptide (GIP)

M. M. Wolfe*, Patricia A. Glazebrook, Milos

Tatalovic, Michael O. Boylan

Overexpression of Bile Acid Synthesis Genes in Pediatric NASH

Adrian Chapa-Rodriguez*, Susan S. Baker,

Wensheng Liu, Colleen A. Nugent, Robert D.

Baker, Lixin Zhu

2:45

#138

3:00

#139

3:15

#140

Non-Alcoholic Fatty Liver Disease Fibrosis

Score Predicts Coronary Artery Disease in

Patients Undergoing Elective Cardiac

Catheterization

Shivank A. Madan*, Febin John, C.S.

Pitchumoni

CD45 CD34 + Circulating Progenitor Cells

Levels Are Associated With the Presence of

Coronary Artery Disease (CAD) in Patients

With Nonalcoholic Fatty Liver Disease

(NAFLD)

Elzafir Elsheikh, Hussain Allawi, Yousef Fazel,

Thomas Jeffers, Zahra Younoszai, Munkhzul

Otgonsuren, Maria C. Albano, Ingrid Schneider,

Michael Campbell, Brian J. Marsiglia, David C.

Chapman, Bryan Raybuck, Zobair M. Younossi*

Efficacy of Rifaximin on Circulating

Endotoxins and Cytokines in Patients With

Non-Alcoholic Fatty Liver

Venkatanarayana Gangarapu, Ali T. Ince*, Birol

Baysal, Yusuf Kayar, Hakan Senturk, Ulkan Kilic,

Ozlem Gok, Ömer Uysal


2:00 PM - 3:30 PM

Room: 156, WCC

Chairs: Keith A. Sharkey, Giovanni Barbara


NEURO-IMMUNE INTERACTIONS AND ENS

DISORDERS


• Learn about the cutting-edge research in neuroimmune regulation of IBS, stress, diverticular disease and visceral hypersensitivity.

2:00

#141

Association Between Immune Markers and

Symptom Severity in Irritable Bowel

Syndrome (IBS)

Annikka V. Polster*, Sean M. Bennet, Hans

Törnblom, Boris Le Nevé, Lena Ohman,

Magnus Simren

2:15

#142

2:30

#143

Neuro-Immune Interactions in Patients With

Diverticular Disease

Cesare Cremon*, M. Raffaella Barbaro,

Eleonora Scaioli, Giovanni Marasco, Marianna

Carapelle, Benatti Elena, Antonio Colecchia,

Davide Festi, Vincenzo Stanghellini, Giovanni

Barbara

Cytokine Activation Is Associated With

Psychological Distress, Motility and Visceral

Hypersensitivity in Irritable Bowel Syndrome

(IBS)

Miranda A. van Tilburg*, Olafur S. Palsson,

Motoyori Kanazawa, David A. Barrow, William

E. Whitehead

2:45

#144

Jejunal Mucosal Eosinophils Show Higher

Corticotropin-Releasing Hormone Content in

Association With Clinical Manifestations in

Diarrhea-Prone Irritable Bowel Syndrome

Eloísa Salvo-Romero, Cristina Martinez, Beatriz

Lobo, Marc Pigrau, Alejandro Sanchez-Chardi,

Ana María González-Castro, Bruno Kotska

Rodiño-Janeiro, Marina Fortea, Fernando

Azpiroz, Carmen Alonso Cotoner, Javier

Santos, María Vicario*

3:00

#145

Aberrant Bystander Immune Response

Triggers Visceral Hypersensitivity in a Th2

Predominant Post-Infectious IBS Mouse

Model

Stephanie Mondelaers*, Javier Aguilera-

Lizarraga, Stavroula Theofanous, Guy E.

Boeckxstaens, Mira M. Wouters

3:15 Inflammation and the ENS - The Next Frontier

Sp224 for Treatment

Roberto De Giorgio

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2:00 PM - 3:30 PM

Room: 144, WCC

Chairs: Raymond Cross, Laurie Keefer



QUALITY OF LIFE AND PSYCHOSOCIAL ISSUES IN

INFLAMMATORY BOWEL DISEASE


• Determine the validity, reliability and reproducibility of the Inflammatory Bowel Disease Disability Index in a

French population-based cohort of IBD patients;

• Estimate the impact of persistent stress on the quality of life and clinical course of patients with Crohn's disease and ulcerative colitis; and

• Validate a self-reported work disability index among

Spanish ulcerative colitis patients.

2:00

#146

Validation of the Inflammatory Bowel Disease

Disability Index in a Population-Based Cohort

Corinne Gower-Rousseau, Hélène Sarter,

Noemie Tavernier, Guillaume Savoye, Mathurin

Fumery, Alain Duhamel, Nathalie Guillon,

Alarcos Cieza, Jean-Frederic Colombel,

Laurent Peyrin-Biroulet*

2:15

#147

2:30

#148

2:45

#149

Does Persistent Stress Impact Quality of Life and Disease Course in Patients With IBD? A 4

Year Prospective Study

Claudia Ramos Rivers*, Eva Szigethy, Kimberly

Baker, Jana G. Hashash, Michael A. Dunn,

Miguel Regueiro, Arthur Barrie, Marc Schwartz,

Jason M. Swoger, Leonard Baidoo, David G.

Binion

Rates of Mental Disorders Are High Among

Individuals With Inflammatory Bowel Disease in United States

Raxitkumar Jinjuvadia*, Benjamin R. Hart,

Ravish Parekh, Siddharth P. Shah, Suthat

Liangpunsakul, Nirmal Kaur

The Indirect Costs and Family Burden of

Pediatric Crohn's Disease in the United States

Stacy A. Kahn*, Chia-Wei Lin, A Burak Ozbay,

Jingdong Chao, Martha Skup

3:00

#150

3:15

#151

Demographic Predictors of High-Cost

Inflammatory Bowel Disease Patients: A

Prospective 5-Year Study

Benjamin H. Click*, Claudia Ramos Rivers, Jana

G. Hashash, Michael A. Dunn, Arthur Barrie,

Marc Schwartz, Jason M. Swoger, Leonard

Baidoo, Miguel Regueiro, David G. Binion

Sexual Dysfunction in Men With Inflammatory

Bowel Disease: A New IBD-Specific Scale

Aoibhlinn M. O'Toole*, Punyanganie S. de Silva,

Matthew B. Lucci, Amanda Ting, Joshua R.

Korzenik, Alan C. Moss, Sonia Friedman


2:00 PM - 3:30 PM

Room: 152, WCC

Chairs: Efi Kokkotou, Enrique Rozengurt


Molecular Biology; Intestinal Disorders;


Child Health; Gastrointestinal Oncology

RECEPTORS AND SIGNALING PATHWAYS-

MECHANISMS UNDERLYING GI FUNCTION


• Appreciate the how receptors function to mediate signal transduction pathways in the GI tract.

2:00

#152

Endosomal Platforms for Signaling Pain

Dane D. Jensen, TinaMarie Lieu, Michelle Halls,

Meritxell Canals, Nigel W. Bunnett*,

Christopher J. Porter

2:15

#153

2:30

#154

AMPK Activation Positively Regulates Fatty

Acid-Stimulated Neurotensin Secretion

Jun Song*, Jing Li, Heidi L. Weiss, Courtney M.

Townsend Jr., B. Mark Evers

Expression of Substance P (SP)-Regulated miR-31-3p Is Increased in Colitis and

Modulates RhoA Expression in Human Colonic

Epithelial Cells

Kai Fang*, Ivy Ka Man Law, Aristea Sideri, Hon

Wai Koon, Dimitrios Iliopoulos, Charalabos

Pothoulakis

2:45

#155

3:00

#156

3:15

#157

Protein Kinase D1 Regulates Agonist-Evoked

Translocation of Protease-Activated

Receptor-2 From the Golgi Apparatus to the

Plasma Membrane

Dane D. Jensen, Marina Gerges, Daniel P.

Poole, Nigel W. Bunnett*

Cyclic-GMP Reduces Redox Stress in the

Colon Epithelium by Increasing Antioxidant

Gene Expression

Bianca N. Islam*, Allison Bridges, Sarah

Sharman, Subbaramiah Sridhar, Darren D.

Browning

Luminal Fatty Acid Sensing Regulates

Mesenteric Lymphatic Flow and Fatty Acid

Transport in Rats

Kazuyuki Narimatsu*, Yasutada Akiba, Izumi

Kaji, Hyder Said, Jonathan D. Kaunitz

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2:00 PM - 3:30 PM

Room: 159, WCC

Chairs: Courtney W. Houchen, Douglas B. Stairs

Sponsored by: Gastrointestinal Oncology; Growth,

Development & Child Health

STEM CELL BIOLOGY AND CANCER


• Gain new insights into the biology of stem cells in normal homeostasis and in GI cancers.

2:00

#158

CD44 and Aldehyde Dehydrogenase Are

Enrichment Markers of Cancer Stem Cells in

Primary Gastric Carcinoma

Phu H. Nguyen, Frederic Mazurier, Lucie

Chambonnier, Pierre Dubus, Geneviève

Belleannée, Denis Collet, Isabelle Soubeyran,

Serge Evrard, Nathalie Senant-Dugot, Francis

Megraud, Christine Varon*

2:15

#159

2:30

#160

KLF5 Promotes Tumorigenicity of

Hepatocellular Carcinoma by Upregulation of

Cancer Stem-Like Cells

Fumiyuki Sato*, Mitsuteru Natsuizaka, Osamu

Maehara, Ayaka Asano, Yoshimasa Kubota, Jun

Itoh, Seiji Tsunematsu, Yoko Tsukuda, Katsumi

Terashita, Masato Nakai, Takuya Sho, Goki

Suda, Kenichi Morikawa, Koji Ogawa, Shunsuke

Ohnishi, Naoya Sakamoto

Unique Non-Saccharide Glycosaminoglycan

Mimetics Selectively Target Cancer Stem Cells

Through Specific Alteration of Growth Factor

Receptor Activation via Mimicry of Heparin

Hexasaccharide

Bhaumik B. Patel*, Nirmita J. Patel, Nehru V.

Sankaranarayanan, Balaji Nagarajan, Umesh R.

Desai

2:45

#161

3:00

#162

3:15

#163

Racial Disparities in Colorectal Cancer:

Responsiveness to Bile Acids

Lulu Farhana, Fadi Antaki, Stephanie Judd,

Lawrence Miller, Mohammad R. Anees, Edi Levi,

Pratima Nangia-Makker, Kulsoom Ahmed,

Yingjie Yu, Adhip P. Majumdar*

CD133-Targeted Oncolytic Adenovirus to

Attack Colon Cancer Stem Cells

Mizuho Sato*, Yoshiaki Miura, Masato

Yamamoto

Gradual Rise in Cancer Stem Cells in the

Crypt-Villous Axis of the Colon During Aging

Yingjie Yu, Pratima Nangia-Makker, Adhip P.

Majumdar*


2:00 PM - 3:30 PM

Room: 140, WCC

Chairs: Philip M. Sherman, Alessio Fasano

Sponsored by: Growth, Development & Child Health;


THE ROLE OF THE GUT MICROBIOME IN

PEDIATRIC GI DISEASES


• Explore the association of specific gut microbial constituents to pediatric diseases;

• Explore host-environment-microbiome interactions in pediatric diseases; and

• Gain insight into therapeutic approaches to alter the gut microbiome.

2:00

#164

Gut Microbiome Biomarkers Are Associated

With Clinical Response to a Low FODMAP

Diet in Children With Irritable Bowel

Syndrome

Bruno P. Chumpitazi*, Emily B. Hollister, Julia L.

Cope, Ruth A. Luna, James Versalovic, Robert

J. Shulman

2:15

#165

2:30

#166

Inflammatory Signature in the Tissue-

Associated Microbiota in Pediatric


Alain J. Benitez*, Christian Hoffmann, Amanda

Muir, Jonathan Spergel, Mei-Lun Wang,

Frederic D. Bushman

Dysbiosis of Syntrophococcus and

Bifidobacterium in Infancy Is the Signature of

Allergic Diseases Development

Yen-Hsuan Ni*, Huey-Huey Chua, Hung-Chieh

C. Chou

2:45

#167

3:00

#168

3:15

#169

The Microbiome Signature of Autistic

Children Is Characterized by Decreased

Diversity and Dysbiosis

Gloria Serena, Anna Sapone*, MariaRosaria

Iovene, Francesca Bombace, Dario Siniscalco,

Chiara Schiraldi, Carmela Bravaccio, Bing Ma,

Mike Humphrys, Jacques Ravel, Laura de

Magistris, Alessio Fasano

Microbiome Changes Associated With

Sustained Eradication of Clostridium difficile

After Fecal Microbiota Transplantation in

Children With and Without Inflammatory

Bowel Disease

Suchitra Hourigan*, Lea Ann Chen, Zoya

Grigoryan, Greggy Laroche, Melissa Weidner,

Cynthia L. Sears, Maria Oliva-Hemker

Assessment of Community Structure and

Predictive Functional Profiling of the Mucosa-

Associated Microbiome Implicates Alterations in Benzoate Metabolism in ‘de novo' IBD After

Pouch-Surgery and in Treatment-Naïve

Pediatric IBD

Jessica Connors*, Richard Hansen, Katherine A.

Dunn, Morgan G. Langille, Richard K. Russell,

Anthony R. Otley, Bradley MacIntyre, Emad El-

Omar, Joseph P. Bielawski, Georgina L. Hold,

Johan Van Limbergen

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2:00 PM - 3:30 PM

Room: 151A, WCC

Chairs: Christopher S. Williams, Claudia D. Andl


TUMOR BIOLOGY AND TUMOR

MICROENVIRONMENT


• Understand basic mechanisms of tumor biology and the influence of the microenviroment on carcinogenesis.

2:00

#170

A New Model of Gastrointestinal Stromal

Tumor (GIST): Activating Mutant BRAF in

Smooth Muscle Cells Results in Gastric, Small

Intestinal and Colonic GIST

Jumpei Kondo*, Robert J. Coffey Jr

2:15

#171

2:30

#172

COMMD1 Restrains Tumor Promoting

Activities of Myeloid Cells in Colon Cancer

Naoteru Miyata*, Haiying Li, Linda N. Geng,

Shelby D. Melton, Ezra Burstein

Examining the Role of BMPs in Stem Cell-

Driven Early Colonic Neoplasia, Both In Vivo and In Vitro

Anne Powell*, Jumpei Kondo, William Fry,

Bruce J. Aronow, Robert J. Coffey Jr

2:45

#173

3:00

#174

3:15

#175

The Absence of NHERF2 Attenuates Colon

Cancer Growth

Michihiro Yoshida*, Peijian He, Chris Yun

The RNA-Binding Protein Tristetraprolin

Controls Intestinal Cell Differentiation and

Tumorigenesis Through the Notch Pathway

Shufei Zhuang, Liangyan Hu, Sandhya Sanduja,

Shahid Umar, Shrikant Anant, Dan A. Dixon*

The Ets-Transcription Factor Etv1 Regulates

Stromal Expansion and Metastasis in

Pancreatic Cancer

Steffen Heeg*, Koushik K. Das, Maximilian

Reichert, Shigetsugu Takano, Basil Bakir, Julia

Caspers, Philip D. Hicks, Anil K. Rustgi


2:00 PM - 3:30 PM

Room: 147, WCC

Chairs: John A. Dumot, Jeffrey Ponsky

POEM - WHAT'S NEW?

2:00

#176

2:15

#177

Peroral Endoscopic Myotomy: A Meta-

Analysis

Emmanuel Akintoye*, Nitin Kumar, Christopher

C. Thompson

Variables Associated With Clinical Failure

After Peroral Endoscopic Myotomy (POEM): A

Case Control Study

Vivek Kumbhari*, Pietro Familiari, Niels C.

Bjerregaard, Saowanee Ngamruengphong,

Mathieu Pioche, Bu Hayee, Nicholas

Eleftheriadis, Weon-Jin Ko, Francois Mion,

Sabine Roman, Alan H. Tieu, Mohamad H. El

Zein, Joo Young Cho, Amyn Haji, Thierry

Ponchon, Rastislav Kunda, Guido Costamagna,

Mouen Khashab

2:30

#178

2:45

#179

3:00

#180

3:15

#181

Safety and Effectiveness of Per-oral

Endoscopic Myotomy (POEM) for Elderly

Patients With Achalasia: A Comparison of

Results for Older and Younger Patients

Kanefumi Yamashita, Hironari Shiwaku*,

Toshihiro Ohmiya, Richiko Beppu, Shinsuke

Takeno, Takamitsu Sasaki, Satoshi Nimura,

Haruhiro Inoue, Yuichi Yamashita

Peroral Endoscopic Short Versus Long

Myotomy for the Treatment of Achalasia: A

Case-Control Study

Xiaowei Tang, Zhiliang Deng, Wei Gong*, Bo

Jiang

Peroral Endoscopic Myotomy for Severe

Achalasia: The Comparison of Full-Thickness

Myotomy and Circular Myotomy

Tianying Duan, Junfeng Zhou, Yuyong Tan,

Deliang Liu*

Outcomes of a 5-Year, Large Prospective

Series of Per oral Endoscopic Myotomy

(POEM). Emphasis on Objective Assessment for GERD and Luminal Patency

Stavros N. Stavropoulos*, Rani J. Modayil,

Collin E. Brathwaite, Bhawna Halwan, Maria M.

Kollarus, David Friedel, Sharon I. Taylor, James

H. Grendell


2:00 PM - 3:30 PM

Room: 209AB, WCC

Chairs: Thomas E. Kowalski, Sharlene L. D'Souza

TOPICS IN UPPER GI BLEEDING

2:00

#182

2:15

#183

2:30

#184

2:45

#185

3:00

#186

Hemospray for Acute Upper Gastrointestinal

Bleeding - UK 'Real-World' Single Center

Experience

Monika M. Widlak*, Dr Haren E. Wijesinghe,

Timothy Molitor Dr, Mohammed Nabil Quraishi,

Tariq Iqbal, Jason Goh

Characteristics of Gastrointestinal Bleeding and Subsequent Endoscopic Therapy After

Implantation of Left Ventricular Assist Device for End Stage Heart Failure

Sandeep Mahajan*, David T. Majure, Amir Taefi,

Julio Salcedo, Maria E. Rodrigo, Mark

Hofmeyer, George Ruiz, Ezequiel Molina,

Steven W. Boyce, Samer Najjar, Farooq Sheikh

Efficacy of Argon Plasma Coagulation

Treatment in Patients With Upper

Gastrointestinal Hemorrhage From the

Lesions With Visible Vessel

Piyapan Prueksapanich, Rapat Pittayanon*,

Rungsun Rerknimitr

Impact of Endoscopic Mucosal Resection on

Gastrointestinal Blood Loss Due to Gastric

Hyperplastic Polyps in Patients With and

Without Cirrhosis

Matthew J. Nelson*, David Grande, Rajesh N.

Keswani, Daniel Ganger, Srinadh Komanduri

Clinical Features of Delayed Bleeding After

Gastric Endoscopic Submucosal Dissection

Associated With Heparin Bridge Therapy

Takuya Inoue*, Masahiko Tsujii, Hideki Lijima,

Yoshito Hayashi, Kengo Nagai, Shunsuke

Yoshii, Toshio Yamaguchi, Tetsuji Fujinaga,

Manabu Araki, Yoshiki Tsujii, Akira Maekawa,

Shoichiro Kawai, Satoshi Hiyama, Shinichiro

Shinzaki, Kenji Watabe, Tetsuo Takehara

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3:15

#187


Randomized Trial of 1-Week vs. 2-Week

Intervals for Endoscopic Ligation in the

Treatment of Patients With Esophageal

Variceal Bleeding

Sarah Sheibani*, Saro Khemichian, Linda A.

Hou, John J. Kim, Arthur Yan, James L.

Buxbaum, Lily Dara, Loren Laine

ASGE Hands-on Workshop (HW2)

3:00 PM - 5:30 PM

Room: HALL A, WCC

Chair: Andrew Y. Wang

ASGE HANDS-ON WORKSHOP: EMR


• Identify areas in need of improvement regarding current practice of endoscopic mucosal resection (EMR);

• Discuss various EMR techniques and their suitability or unsuitability for specific target lesions in various luminal organs; and

• Apply new techniques and evidence-based practices to daily clinical practice to improve upon the safety and efficacy of EMR.

Sp224a Harry R. Aslanian, Norio Fukami, Gregory G.

Ginsberg, Chris M. Hamerski, Sanjay Hedge,

Jennifer L. Maranki, Vanessa M. Shami, Daniel

S. Strand


4:00 PM - 5:30 PM

Room: 102A, WCC

Chairs: Amir Zarrinpar, Rohit Kohli

Sponsored by: Obesity, Metabolism & Nutrition; Pancreatic

Disorders; Gastrointestinal Oncology; Intestinal Disorders

EATING FAT: THE GOOD, THE BAD AND THE UGLY


• Understand the impact of the reduction in fat content of the American diet over the past 40 years on the emergence of obesity and metabolic syndrome;

• Understand the importance of genetic factors and dietary fat content and composition in obesity and the metabolic syndrome;

• Understand the implications of dietary fat-induced alterations of the gut microbiota and metabolic risk factors; and

• Understand the role of dietary fat in intestinal inflammation and development of GI cancers.


Samuel Klein, MD

4:06 Why Low-Fat, Low-Calorie Diets Don't Work

Sp229 David Ludwig

4:27 Nutrigenomics, Dietary Fatty Acids and

Sp230 Metabolic Syndrome

Helen Roche

4:48 Dietary Fat, the Gut Microbiome and

Sp231 Metabolic Risk

Eugene B. Chang

5:09 Impact of Dietary Fat on Intestinal

Sp232 Inflammation and Malignancy

R. Balfour Sartor


4:00 PM - 5:30 PM


Chairs: Guadalupe Garcia-Tsao, Louis M. Wong Kee

Song, Shimul A. Shah

Sponsored by: AASLD; ASGE; SSAT

MANAGING GASTROINTESTINAL BLEEDING IN

CIRRHOSIS


• Identify the different portal hypertensive sources of hemorrhage in patients with cirrhosis;

• Recognize first and second line therapies in the treatment of the different sources; and

• Understand the role of surgery in this process.

4:00 Management of Esophageal Variceal

Sp225 Hemorrhage

Guadalupe Garcia-Tsao

4:20 Management of Gastric Variceal Hemorrhage

Sp226 and Ectopic Varices

Stephen H. Caldwell

4:40 Management of Portal Hypertensive

Sp227 Gastropathy and GAVE

Louis M. Wong Kee Song

5:00 Role of Surgery in Variceal Hemorrhage

Sp228 Shimul A. Shah



4:00 PM - 5:30 PM

Room: 154, WCC

Chairs: David C. Whitcomb, Alexandrox Tzatsos

Sponsored by: Pancreatic Disorders; Gastrointestinal

Oncology; Regulatory Peptides, Cell Signaling & Molecular

Biology

EPIGENETICS: A NEW PARADIGM FOR COMPLEX

GI DISEASES


• Recognize a new paradigm for understanding, diagnosing and treating complex GI diseases based on the metabolic control of gene expression by epigenetic mechanisms, including DNA methylation, chromatin modification (histones' marks and their writer, readers, and erasers), and silencing by non-coding long- and microRNAs;

• Discuss regulation of inflammation and fibrosis in metabolic target organs by epigenetic cross-talk;

• Understand the diagnostic potential for GI cancer screening based on the presence of carcinogenic

"epigenetic field defects" at the intersection of chronic inflammation-associated GI cancers; and

• Examine pharmacological targeting of the epigenetic machinery to prevent or treat GI malignancy.

4:00 Novel Paradigm for Complex GI Diseases:

Sp233 Epigenetics, Epigenomics and Metabolism

Raul A. Urrutia

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4:20 Inflammation and Fibrosis: Epigenetics of the

Sp234 Hepatic Wound Healing Response

Jelena Mann

4:40 GI Cancer Screening With Epigenetic Markers:

Sp235 Insights From the Pancreatitis

(Inflammation)-Cancer Progression Model

Volker Ellenrieder

5:00 The Promise of Epigenetic Therapeutics in GI

Sp236 Malignancies

Nita Ahuja



4:00 PM - 5:30 PM

Room: 103A, WCC

Chairs: William M. Grady, David C. Metz


Gastrointestinal Oncology; Immunology, Microbiology &

Inflammatory Bowel Diseases

MOLECULAR MARKERS IN THE DIAGNOSIS AND

MANAGEMENT OF GASTROINTESTINAL

NEOPLASIA: PERSONALIZED MEDICINE AT ITS

BEST


• Understand how circulating tumor cells can be used to manage GI cancer; and

• Identify the uses of molecular markers for the prevention and treatment of GI cancer.

4:00 Biomarkers for Barrett's Detection and

Sp237 Prognostication

Kausilia K. Krishnadath

4:22 Comprehensive Molecular Characterization of

Sp238 Gastric Adenocarcinoma

Adam Bass

4:44 Identifying Circulating Epithelial Cells for

Sp239 Early Pancreatic Cancer Detection

Andrew D. Rhim

5:06 Personalized Treatment for CRC

Sp240 Scott Kopetz


4:00 PM - 5:30 PM

Room: 101, WCC

Chairs: Nicholas O. Davidson, Wayne I. Lencer

Sponsored by: Intestinal Disorders

XENOBIOTICS, MICROBIOTA AND INTESTINAL

DISEASE


• Examine new developments in xenobiotic regulation of intestinal microbial abundance and function.

4:00

Sp241

Gut Reactions: Understanding Drug

Metabolism by the Human Microbiota

Emily Balskus

4:30 Xenobiotics and Intestinal Injury

Sp242 Axel Behrens

5:00 Intestinal Efflux Transporters and Multi-Drug

Sp243 Resistance in Inflammation

Elke Cario


4:00 PM - 5:30 PM

Room: 102B, WCC

Chairs: David L. Jaffe, Uzma D. Siddiqui

ROLE OF ENDOSCOPY IN 'IDIOPATHIC'

RECURRENT ACUTE PANCREATITIS

4:00 Evaluation of RAP: Role of EUS

Sp244 Tyler Stevens

4:15 Sphincterotomy: Who, When, and What Prior

Sp245 Evaluation?

Bret T. Petersen

4:30 Prevention of Post-ERCP Pancreatitis in the

Sp246 High Risk Patient

Georgios I. Papachristou

4:45 Minor Sphincterotomy in Pancreas Divisum: Is

Sp247 There Supporting Evidence?

Gregory A. Cote


4:00 PM - 5:30 PM

Room: 144, WCC

Chairs: Eun Ji Shin, Felice Schnoll-Sussman

THE MANY WAYS TO SKIN A POLYP

4:00 Basic Polypectomy: Tools and Optimal

Sp248 Techniques

Heiko Pohl

4:15 EMR for the Experts: Snares, Injectates, ESU

Sp249 Settings and Underwater Techniques

Michael J. Bourke

4:30 Colon ESD: The Right Approach for Large,

Sp250 Difficult, and Recurrent Polyps

Yutaka Saito

4:45 Surgery Versus Combined Surgery-

Sp251 Endoscopic Resection of Difficult Polyps

Traci L. Hedrick

ASGE Special Session (2320)

4:00 PM - 5:30 PM

Room: 149AB, WCC

Chairs: Sarah "Betsy" Rodriguez, Aasma Shaukat

HOW TO SUCCEED IN ENDOSCOPY: THE EARLY

YEARS

4:00 Do I Need Additional/Advanced Training to

Sp252 Succeed?

Walter Coyle

4:15 How to Succeed in Private Practice

Sp253 Karen L. Woods

4:30 Building an Academic Career

Sp254 Amitabh Chak

4:45 Can I Have the Best of Both Worlds?

Sp255 Glenn Eisen

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AGA Distinguished Abstract Plenary (2325)

4:00 PM - 5:30 PM

Room: 156, WCC

Chairs: Andrew B. Leiter, Charalabos Pothoulakis


Molecular Biology; Growth, Development & Child Health

GROWTH FACTOR SIGNALING IN GI TRACT

HOMEOSTASIS - REGULATORY PEPTIDES, CELL

SIGNALING AND MOLECULAR BIOLOGY

DISTINGUISHED ABSTRACT PLENARY AND

SECTION BUSINESS MEETING


• Recognize the importance of regulatory peptides in gastrointestinal tract homeostasis.

4:00

#188

Epithelial Tyrosine Phosphatase SHP-1

Controls Growth and Secretory Cell

Differentiation in the Small Intestine

Caroline Leblanc*, Marie-Josée Langlois,

Nathalie Rivard

4:15

#189

4:30

#190

4:45

#191

5:00

#192

5:15

#193

Neurogenin 3 Gene Dosage and Expression

Level Controls Allocation Between

Enteroendocrine and Goblet Cell

Differentiation From Multipotential Cells in the Intestine

Joyce Li*, Andrew B. Leiter

The Stimulation of Quiescent Stem Cells by

Glucagon-Like Peptide-2 (GLP-2) in the

Murine Small Intestine

Bradley Smither*, Hilary Pang, Patricia L.

Brubaker

Notch Signaling Induces LGR5 + Antral Stem

Cell Proliferation and Tumorigenesis via

Activation of mTOR

Elise Demitrack*, Dafydd Thomas, Thomas J.

Giordano, Linda C. Samuelson

Regulation of Gastric LGR5 +VE Cell

Homeostasis by Bone Morphogenetic Protein

(BMP) Signaling and Inflammatory Stimuli

Hidehiko Takabayashi, Maria Y. Mao, Tuo Ji,

Kathryn A. Eaton, Andrea Todisco*

Helicobacter-Induced Accumulation of

Schlafen-4+ Myeloid-Derived Suppressor Cells

Requires Hedgehog Signaling and Correlates

With Gastric Metaplasia

Lin Ding*, Michael M. Hayes, Amanda

Photenhauer, Juanita L. Merchant


4:00 PM - 5:30 PM

Room: 103B, WCC

Chairs: Braden Kuo, Richard W. McCallum


Esophageal, Gastric & Duodenal Disorders

FUNCTIONAL DYSPEPSIA, NAUSEA AND

VOMITING


• Review the latest advances in the pathophysiology, diagnostic evaluations, symptom correlations and treatment of functional dyspepsia, as well as nausea and vomiting.

4:00

#194

Eosinophils and Mast Cells in Functional

Dyspepsia: Ultrastructural Evaluation of

Activation

Hanne Vanheel*, María Vicario, Tim Vanuytsel,

Jan F. Tack, Ricard Farré

4:15

#195

4:30

#196

4:45

#197

Rifaximin for the Treatment of Functional

Dyspepsia: A Double-Blinded Randomized

Placebo-Controlled Trial

Victoria P. Tan*, Sze Hang Kevin Liu, Frank Y.

Lam Dr, Ivan F. Hung, Wai K. Leung

Ameliorating Effect of Transcutaneous

Electroacupuncture on Impaired Gastric

Accommodation Induced by Cold Meal in

Healthy Subjects

Zhihui Huang*, Nina Zhang, Ning Dai, Jiande

Chen, Jieyun Yin

Up-Regulations of Gastric TRPV Receptors and Decreased Serum Concentration of BDNF inPatients With Functional Dyspepsia (FD)

Cynthia K. Cheung*, Lin Lin Lan, Yawen Chan,

Justin C. Wu

5:00

#198

5:15

#199

Differences Between Nausea and Vomiting in

Diabetic and Idiopathic Gastroparesis

Henry P. Parkman*, Erin Hallinan, William L.

Hasler, Thomas L. Abell, Richard W. McCallum,

John O. Clarke, Gianrico Farrugia, Linda Anh B.

Nguyen, Irene Sarosiek, William J. Snape Jr.,

Linda A. Lee, James Tonascia, Frank A.

Hamilton, Pankaj J. Pasricha

Gastric Physiology Test Correlations in

Functional Dyspepsia

Yuri A. Saito*, Ann E. Almazar, Giles Locke,

Michael Camilleri, Duane D. Burton, Ernest P.

Bouras, Colin W. Howden, Brian E. Lacy, John

K. DiBaise, Charlene M. Prather, Bincy

Abraham, Hashem B. El-Serag, Paul Moayyedi,

Linda M. Herrick, Lawrence A. Szarka, Frank A.

Hamilton, Katherine E. Tilkes, Cathy D. Schleck,

Nicholas J. Talley

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4:00 PM - 5:30 PM

Room: 145A, WCC

Chairs: Glenn Furuta, Nirmala Gonsalves



Child Health; Imaging & Advanced Technology

THERAPEUTIC IMPLICATIONS OF RESEARCH

ADVANCES IN EOSINOPHILIC ESOPHAGITIS


• Explore recent developments in pathophysiology of

Eosinophilic esophagitis.

4:00

#200

Allergen Challenge Sensitizes TRPA1 in Vagal

Sensory Neurons and Afferent C-Fibers in

Guinea Pig Esophagus

Zhenyu Liu, Youtian Hu, Xiaoyun Yu, Ming Tse,

Pankaj J. Pasricha, Shaoyong Yu*

4:15

#201

4:30

#202

Claudin-7 Dysregulation in Pediatric

Eosinophilic Esophagitis: A Role for TGFb in

Esophageal Epithelial Barrier Dysfunction

Shahan D. Fernando*, Kathryn A. Biette, Glenn

Furuta, Joanne C. Masterson

Omeprazole and Fluticasone Inhibit IL-13-

Stimulated Eotaxin-3 Expression by

Esophageal Epithelial Cells Through Different

Mechanisms and With Additive Effects:

Rationale for Combining PPIs With Topical

Steroids for EoE Patients

Xi Zhang, Xiaofang Huo, Chunhua Yu, Qiuyang

Zhang, Yuji Nadatani, Yuji Tamagawa, Peiguo

Ding, David H. Wang, Thai H. Pham, Kerry B.

Dunbar, Stuart J. Spechler, Rhonda F. Souza,

Edaire Cheng*

4:45

#203

5:00

#204

5:15

#205

A STAT6 Inhibitor (AS1517499) and a Tyrosine

Kinase Inhibitor (Leflunomide) Block IL-13/

STAT6 Signaling and Eotaxin-3 Expression in

Esophageal Fibroblasts and Epithelial Cells:

Promising Agents to Improve Inflammation and Prevent Fibrostenosis in EoE

Edaire Cheng*, Xi Zhang, Xiaofang Huo,

Chunhua Yu, Qiuyang Zhang, Yuji Nadatani,

Yuji Tamagawa, Peiguo Ding, David H. Wang,

Thai H. Pham, Kerry B. Dunbar, Stuart J.

Spechler, Rhonda F. Souza

Epithelial Lysyl Oxidase Is an Early Mediator of Fibrotic Remodeling in Eosinophilic

Esophagitis

Amanda Muir*, Kara K. Dods, Kelly A. Whelan,

Jamie Merves, Alain J. Benitez, Maureen

DeMarshall, Jonathan Spergel, Gary W. Falk,

Rebecca Wells, Mei-Lun Wang, Hiroshi

Nakagawa

Differential Proteomic Analysis of Esophageal

Tissue Reveals Galectin-3 As Prominent

Biomarker Candidate for Esophageal

Eosinophilia

Girish Hiremath*, John E. E. Wiktorowicz,

Kizhake V. Soman, Christof Straub, Christina

Nance, Melinda Mata, Norma M. Quintanilla,

Konrad Pazdrak, Anthony Olive, Alexander

Kurosky, Carla M. Davis



4:00 PM - 5:30 PM

Room: 147, WCC

Chairs: Banke Agarwal, Subbaramiah Sridhar

EXPANDING THE FRONTIERS OF EUS

4:00

#206

4:15

#207

EUS-Guided Pseudocyst Drainage:

Prospective Evaluation of Early Removal of

Fully Covered Self Expandable Metal Stents

With Pancreatic Ductal Stenting in Selected

Patients

Vinay K. Dhir*, Anthony Y. Teoh, Suryaprakash

Bhandari, Mukta Bapat, Nitin Joshi, Amit P.

Maydeo

Transpapillary Drainage Has No Benefit on

Treatment Outcomes in Patients Undergoing

EUS-Guided Transmural Drainage of

Pancreatic Fluid Collections: A Multi-Center

Study

Dennis Yang*, Sunil Amin, Susana Gonzalez,

Daniel Mullady, Stephen Hasak, Srinivas

Gaddam, Steven A. Edmundowicz, Mark A.

Gromski, John M. DeWitt, Mohamad H. El Zein,

Mouen Khashab, Satish Nagula, Samir Kapadia,

Jonathan Buscaglia, Juan Carlos Bucobo,

Alexander Schlachterman, Mihir S. Wagh, Peter

V. Draganov, Min Kyu Jung, Tyler Stevens, John

J. Vargo II, Rajesh N. Keswani, Ryan Law,

Srinadh Komanduri, Patrick S. Yachimski,

Tomas DaVee, Anoop Prabhu, Robert T. Lapp,

Richard S. Kwon, Rabindra R. Watson, Adam J.

Goodman, Natasha Chhabra, Wallace J. Wang,

David L. Carr-Locke, Christopher J. DiMaio

4:30

#208

4:45

#209

No Advantage to Pancreatic Duct Stenting

When Performing Transmural Endoscopic

Drainage of Pancreatic Fluid Collections: A

Meta-Analysis and Review of the Literature

Sunil Amin*, Dennis Yang, Aimee L. Lucas,

Susana Gonzalez, Christopher J. DiMaio

Endoscopic Ultrasound (EUS)-Guided

Treatment of Gastric Fundal Varices With

Combined Coiling and Cyanoacrylate Glue

Injection (5 Year Outcome Data)

Yasser M. Bhat*, Frank Weilert, Steve D. Kane,

Janak N. Shah, Oriol Sendino, Chris M.

Hamerski, Kenneth Binmoeller

5:00

#210

Contrast Enhanced Endoscopic Ultrasound of the Colon Is a Marker of Early Therapy

Response Following Anti-TNF-Therapy in

Patients With Acute Ulcerative Colitis.

Mark Ellrichmann*, Johannes Bethge,

Alexander Arlt, Sebastian Zeissig, Berenice

Brandt, Janina Lankau, Susanna Nikolaus,

Stefan Schreiber, Annette Fritscher-Ravens

5:15 State of the Art - Treatment of Gastril Varies

Sp256 Stephen H. Caldwell

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4:00 PM - 5:30 PM

Room: Ballroom B, WCC

Chairs: Ryan Law, Peter Legnani

UPPER GI THERAPY, OUTCOMES AND

EFFECTIVENESS

4:00

#211

4:15

#212

4:30

#213

Long Term Outcomes and Prognosis of

Endoscopic Submucosal Dissection for Early

Gastric Cancer: A Multi-Institutional Joint

Study

Satoshi Tanabe*, Kenji Ishido, Takashi Kosaka,

Haruhisa Suzuki, Junko Fujisaki, Hiroyuki Ono,

Tsuneo Oyama, Hisashi Doyama, Masaaki

Kobayashi, Noriya Uedo, Takashi Toyonaga,

Shiro Oka, Wasaburo Koizumi

Management and Long-Term Outcomes After

Gastric Endoscopic Submucosal Dissection in an European Center

Diogo Libânio*, Luís P. Afonso, Rui Henrique,

Mario Dinis-Ribeiro, Pedro Pimentel-Nunes

Comparative Effectiveness of Radiofrequency

Ablation and Argon Plasma Coagulation for

Treatment of Gastric Antral Vascular Ectasia:

A Systematic Review and Meta-Analysis

Tarun Rustagi*, Thomas McCarty

4:45

#214

5:00

#215

Factors Predictive of Complications and

Recurrence After Endoscopic Mucosal

Resection (EMR) of Sporadic, Non-Ampullary

Duodenal Adenomas: Results From a Large

Single Center Study

Ajaypal Singh*, Uzma D. Siddiqui, Vani J.

Konda, Emma Whitcomb, Mariano Gonzalez-

Haba Ruiz, Ann Koons, Andres Gelrud, Shu-

Yuan Xiao, John Hart, Irving Waxman

The Risk Factors for Metastasis in Non-

Ampullary Duodenal Neuroendocrine Tumors

Measuring 20 mm or Less in Diameter: A

Multicenter Retrospective Trial in Japan

Waku Hatta*, Tomoyuki Koike, Katsunori Iijima,

Nobuyuki Ara, Kiyotaka Asanuma, Kaname

Uno, Naoki Asano, Akira Imatani, Atsuko

Kasajima, Fumiyoshi Fujishima, Hironobu

Sasano, Tooru Shimosegawa

5:15 State of the Art - ESD and EMR in Upper GI

Sp257 Tract: A North America Perspective

Peter V. Draganov



4:00 PM - 5:30 PM

Room: 209AB, WCC

Chairs: J. David Horwhat, Charles J. Lightdale

WHAT'S NEW IN ENDOSCOPIC THERAPY FOR

BARRETT'S DYSPLASIA AND NEOPLASIA

4:00

#216

4:15

#217

4:30

#218

4:45

#219

5:00

#220

5:15

#221

A Prospective Randomized Controlled Trial on Endoscopic Mucosal Resection (EMR)

Versus Water-Jet Assisted Endoscopic

Submucosal Dissection (WESD) for Early

Barrett's Neoplasia

Grischa Terheggen, Eva-Maria Rutz, Michael

Vieth, Brigitte Schumacher, Horst Neuhaus*

Comparison of the Histopathological Effects of Two Electrosurgical Currents in an In-Vivo

Porcine Model of Esophageal Endoscopic

Mucosal Resection

Farzan F. Bahin*, Nicholas G. Burgess, Shahrir

Kabir, Hema Mahajan, Duncan J. McLeod,

Vishnu Subramanian, Maria Pellise, Rebecca

Sonson, Michael J. Bourke

Polyglycolic Acid Sheets With Fibrin Glue for the Prevention of Postoperative Stricture

After Esophageal Endoscopic Submucosal

Dissection

Yoshiki Sakaguchi*, Yosuke Tsuji, Yosuke

Kataoka, Itaru Saito Dr., Satoki Shichijo, Chihiro

Minatsuki, Itsuko Hirayama, Keiko Niimi, Satoshi

Ono, Shinya Kodashima, Nobutake Yamamichi,

Mitsuhiro Fujishiro, Kazuhiko Koike

Efficacy of Viscous Budesonide Slurry in the

Prevention of Esophageal Stricture Formation

After Complete Endoscopic Resection of

Short Segment Barrett's Oesophagus With

High-grade Dysplasia and Early Esophageal

Adenocarcinoma

Farzan F. Bahin*, Mahesh Jayanna, Stephen J.

Williams, Eric Y. Lee, Michael J. Bourke

Preliminary Evaluation of Submucosal

Tunneling Endoscopic Resection for the

Treatment of Large Symptomatic Submucosal

Tumors Oringinating From the Muscularis

Propria Layer in the Esophagus and Cardia

Chen Zhang, Quan-Lin Li, Mei-Dong Xu*, Li-

Qing Yao, Ping-Hong Zhou

Time to Significant Reduction of Segment

Length of Barrett's Esophagus After

Radiofrequency Ablation Predicts Treatment

Response

Daniel K. Chan*, Cadman L. Leggett,

Emmanuel C. Gorospe, Lori S. Lutzke, Prasad

G. Iyer, Kenneth K. Wang

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AGA Special Session‡ (2342)

Saturday 5:30 PM - 6:30 PM

Room: 145 -147, Foyer

Sponsored by: Clinical Practice, Esophageal, Gastric &

Duodenal Disorders, Gastrointestinal Oncology, Growth,

Development & Child Health, Imaging & Advanced

Technology, Immunology, Microbiology & Inflammatory

Bowel Diseases, Intestinal Disorders, Liver & Biliary,

Neurogastroenterology & Motility, Obesity, Metabolism &

Nutrition, Pancreatic Disorders, Regulatory Peptides, Cell

Signaling & Molecular Biology

AGA SECTION EDUCATION AND NETWORKING

EXCHANGE


• Interact with section members;

• Learn about section events and plans for the future; and

• View top posters from each section and discuss with the authors.

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lecture sessions—scientific sessions scientific sessions

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lecture sessions—scientific sessions scientific sessions

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