PSVue® Publications
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Chan MM, Gray BD, Pak KY, Fong DF. 2015. Non-invasive in vivo imaging of
arthritis in a collagen-induced murine model with phosphatidylserine-binding
near-infrared dye. Arthritis Research & Therapy. epub ahead of print.
Li J, Gerlach RL, Jonsson CB, Gray BD, Pak KY, Ng CK. 2015. Characterization
of 18F-dipicolylamine (DPA) derivatives in cells infected with influenza virus.
Nucl Med Biol., 42, 283-291.
Rice DR, Plaunt AJ, Turkyilmaz S, Smith M, Wang Y, Rusckowski M, Smith,
BD. 2015. Evaluation of [111In]-Labeled Zinc-Dipicolylamine Tracers for SPECT
Imaging of Bacterial Infection. Mol. Imaging Biol., 17, 204-213.
Hu Q, Gao M, Feng G, Chen X, Liu B. 2015. A Cell Apoptosis Probe Based on
Fluorogen with Aggregation Induced Emission Characteristics. ACS Appl. Mater.
& Interfaces, 7, 4875-4882.
Rice DR, Gan H, Smith, BD. 2015 Bacterial Imaging and Photodynamic
Inactivation Using Zinc(II)-Dipicolylamine BODIPY Conjugates. Photochem. and
Photobiol. Sci. 14, 1271-1281.
Smith BD. Smart Molecules for Imaging, Sensing and Health (SMITH), 2015
Beilstein J. Org. Chem. 11, 2540-2548.
Turkyilmaz S, Rice DR, Palumbo R, Smith BD. 2014. Recognition of Anionic
Cell Membranes using Targeted Liposomes Coated with Zinc(II)bis(dipicolylamine) Affinity Units. Org. Biomol. Chem. 12, 5645-5655
Hensley H, Devarajan K, Johnson JR, Piwnica-Worms D, Godwin AK, Von
Mehren M, Rink L. 2014. Evaluating new therapies in gastrointestinal stromal
tumor using in vivo molecular optical imaging. Cancer Biol Ther. 5(7):911-8.
Plaunt, A. P.; Harmatys, K. M.; Wolter, W. R.; Suckow, M. A.; Smith, B. 2014.
Library Synthesis, Screening and Discovery of Modified Zinc(II)bis(dipicolyamine) Probe for Enhanced Molecular Imaging of Cell Death.
D.Bioconj. Chem. 25. 724-733.
Kwong JM, Hoang C, Dukes RT, Wee RW, Gray BD, Pak KY, Caprioli J. 2014.
Bis(Zinc-Dipicolylamine), Zn-DPA, a New marker for Apoptosis. Investigative
Ophthalmology & Visual Science, 55, 4913-4921.
Hu X, Wang Q, Liu Y, Liu H, Cheng K, Robinson W, Gray BD, Pak KY, Yu A,
Cheng Z. 2014. Optical imaging of articular cartilage degeneration using nearinfrared dipicolylamine probes. Biomaterials, 35, 7511-7521.
Palmowskl K, Rix A, Behrendt FF, Lederle W, Mottaghy FM, Gray BD, Pak KY,
Palmowski M, Kiessling F. 2014. A low molecular weight zinc2+-dipicolylaminebased probe detects apoptosis during tumor treatment better than an annexin Vbased probe. European Radiology 24,363-370.
Version 7: July 2016
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Clear K.J., Stround S., Smith B.D.. 2013 . Dual Colorimetric and Luminescent
Assay for Dipicolinate, a Biomarker of Bacterial Spores. Analyst ,138, 70797082.
O'Neil EJ, Jiang H, Gassensmith JJ, Smith BD. 2013. Effect of Bridging Anions
on the Structure and Stability of Phenoxide Bridged Zing Dipicolylamine
Coordination Complexes. Supramol. Chem, 25, 315-322.
 Chu C, Huang X, Chen CT, Zhao Y, Luo JJ, Gray BD, Pak KY, Dun N. 2013. In
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vivo imaging of brain infarct with a novel fluorescent probe PSVue 794 in a rat
middle cerebral artery occlusion-reperfusion model. Molecular Imaging 12, 816.
Smith, B. A.; Xiao, S.; Hamartys, K. M.; Cole, E. L.; Plaunt, A. L.; Wolter, A.;,
Suckow, M. A.; Smith, B. D. 2013. Enhanced Cell Death Imaging Using
Multivalent Zinc(II)-Bis (dipicolylamine) Fluorescent Probes. Mol. Pharmaceut.
10, 3296-3303
Xiao, S, Turkyilmaz, Smith BD. 2013. Convenient Synthesis of Multivalent
Zinc(II)-Dipicolylamine Complexes for Molecular Recognition. Tetraheddron
Lett., 54, 861-864.
Smith BA and Smith BD. 2012. Biomarkers and Molecular probes for Cell Death
Imaging and Targeted Therapeutics. Bioconjugate Chemistry, 23, 1989-2006.
Ngo HT, Liu X, Jolliffe KA. 2012. Anion recognition and sensing with Zn(II)dipicolylamine complexes. Chem. Soc. Rev., 41:4828-4965.
Smith BA, Xie BW, Beek E, Que I, Blankevoort V, Xiao S, Cole E, Hoehn M,
Kaijzel E, Lowik C, Smith BD. 2012. Multicolor Fluorescence Imaging of
Traumatic Brain Injury in a Cryolesion Mouse Model. ACS Chem. Neuroscience
3, 530-537.
Buehler A, Herzo E, Ale A, Smith B, Ntziachristos V, Razansky, D. 2012. High
Resolution tumor Targeting in Living Mice by means of Multispectral
Optoacoustic Tomography. EJNMMI Research 2, 1-6.
Liu G, Chooi KY, Bhirde A, Swierczewsks JY, Lee SW, Park JH, Hong JI, Xie J,
Niu G, Kiesewetter DO, Lee S, Chen X. 2012. Sticky nanoparticles: A Platform
for siRNA Delivery by a Bis(zinc(ll) dipicolylamine)-Functionalized, SelfAssembled Nanoconjugate. Angew Chem. Int. 51, 445-449.
Li J, Gray BD, Pak KY, Ng CK. 2012. Radiolabeling and optimizing of zinc(II)
dipicolylamine (DPA) with three 18F-prosthetic groups (18F-NFP, 18F-SFB, and
18F-FET) as potential infectious imaging agents. J. Labeled Compounds and
Radiopharmaceuticals 55:149-154.
White AG, Gray BD, Pak KY, Smith BD. 2012. Deep-red fluorescent imaging
probe for bacteria. Bioorganic and Medicinal Chemistry Letters 22, 28332836.
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Liu X, Cheng D, Gray BD, Wang, Y, Akalin A, Rusckowski M, Pak KY, Hnatowich
D. 2012. Radiolabeled Zn-DPA as a potential infection imaging agent. Nucl Med
Biol. 39, 709-714.
Wyffels L, Gray BD, Barber C, Woolfenden J, Pak KY, Liu, Z. 2011. Synthesis
and preliminary evaluation of radiolabeled bis(zinc(II)-Dipicolylamine)
coordination complexes as cell death imaging agents. Bioorganic and
Medicinal Chemistry, 19, 3425-3433.
Thakur M, Zhang K, Paudyal B, Devakumar D, Covarrubias M, Cheng C, Gray
BD, Wickstrom E, Pak KY. 2012. Targeting Apoptosis for Optical Imaging of
Infection. Molecular Imaging and Biology, 14, 163-171.
Wyffels L, Gray BD, Barber C, Pak KY, Forbes S, Mattis JA, Woolfenden J, Liu,
Z. 2012. Detection of myocardial ischemia-reperfusion injury using a fluorescent
near-infrared zinc(II)-dipicolylamine probe and 99mTc-glucarate. Molecular
Imaging and Biology 11, 1536.
Kersigo J, D’Angelo A, Gray BD, Soukup GA, Fritzsch B. 2011. The role of
sensoryorgans and the forebrain for the development of the craniofacial shape as
revealed by Foxg1-cre-mediated microRNA loss. Genesis, Apr, 49 (4): 326-41.
Smith BA, Gammon ST, Xiao S, Wang W, Chapman S, Ryan McDermott R,
Suckow MA, Johnson JR, Piwnica-Worms D, Gokel GW, Smith BD, Leevy WM.
2011. In Vivo Optical Imaging of Acute Cell Death Using a Near-Infrared
Fluorescent Zinc-Dipicolylamine Probe. Mol. Pharmaceutics, 8, 583-590.
Gray BD. 2011. PSVues: Novel small molecule probes for fluorescent
imaging of apoptosis and bacterial infections in vitro and in vivo.
http://www.nature.com/app_notes/nmeth/2011/111204/full/an7924.
html, Accessed 02/03/2012.
Smith BA, Xiao S, Wolter W, Wheeler J, Suckow MA, Smith BD. 2011. In Vivo
Targeting of Cell Death Using a Synthetic Fluorescent Molecular Probe.
Apoptosis, 16, 722-731
Baumes JM, Gassensmith JJ, Giblin J, Lee JJ, White AG, Culligan WJ, Leevy
WM, Kuno M, Smith BD. 2010. Storable, Thermally Activated, Near-Infrared
Chemiluminescent Dyes and Dye-Stained Microparticles for Optical Imaging.
Nature Chem. 2, 1025-1030.
White AG, Fu N, Leevy WM, Lee JL, Blasco MA, Smith BD. 2010. Optical
Imaging of Bacterial Infection in Living Mice Using Deep-Red Fluorescent
Squaraine Rotaxane Probes. Bioconj. Chem. 21, 1297-1304.
Smith BA, Akers WJ, Leevy WM, Lampkins AJ, Xiao S, Wolter W, Suckow MA,
Achilefu S, Smith BD. 2010. Optical Imaging of Mammary and Prostate Tumors
in Living Animals Using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe
for Anionic Cell Surfaces. J. Amer. Chem. Soc., 132, 67-69.
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Hope-Roberts M, Wainwright M, Horobin RW. 2010. Real Time Imaging of
Bacteria in Living Mice Using a Fluorescent Dye. Biotechnic &
Histochemistry., Early Online 1-4.
Kim YS, Park HH, Rhee HW, Hong JI, Han K. 2009. Neutrophils with Toxic
Granulation Show High Fluorescence with Bis(Zn2+-dipicolylamine) Complex.
Annals of Clinical & Laboratory Science, 39,114-119.
Leevy WM, Lambert TN, Johnson JR, Morris J, Smith BD. 2008. Quantum Dot
Probes for Bacteria Distinguish Escherichia coli Mutants and Permit In Vivo
Imaging. Chem. Comm., 20, 2331-2333. Highlighted by the journal as a Hot
Paper.
Leevy WM, Gammon ST, Johnson JR, Lampkins AJ, Jiang H, Marquez M,
Piwinica-Worms D, Smith BD. 2008. Non-Invasive Optical Imaging of
Staphylococcus Aureus Bacterial Infection in Living Mice Using a BisDipicolyamine-Zinc(II) Affinity Group Conjugated to a Near Infrared Fluorophore.
Bioconj. Chem. 19, 686-692.
Johnson JR, Jiang H, Smith BD. 2008. Zinc (II)-Coordinated Oligotyrosine: A
New Class of Cell Penetrating Peptide. Bioconj. Chem. 19, 1033-1039. Chosen
by editor as the cover article.
DiVittorio KM, Leevy WM, O'Neil EJ, Johnson JR, Vakulenko S, Morris JD,
Rosek KD, Serazin N, Hilkert S, Hurley S. Marquez M, Smith BD. 2008. Zinc.(II)Coordination Complexes as Membrane Active Fluorescent Probes and
Antibiotics. Chem Biochem., 9, 286-293.
Rhee HW, Choi HA, Han K, Hong JI. 2007. Selective Fluorescent Detection of
Flavin Adenine Dinucleotide in Human Eosinophils by Using Bis(Zn2+Dipicolylamine) Complex. JACS Communications, 129, 4524-4525.
Johnson JR, Fu N, Arunkumar E, Leevy WM, Gammon ST, Piwnica-Worms D,
Smith BD. 2007. Squaraine-Rotaxanes: Superior Substitutes for Cy-5 in
Molecular Probes for Near-Infrared Fluorescence Cell Imaging. Angew. Chem.
Int. Ed, 46, 5528-5531.
Leevy WM, Serazin N, Smith B.D. 2006. Optical Imaging of Bacterial Infection
Models.; Drug Discov. Today Dis. Models, 4, 91-97.
DiVittorio KM, Johnson JR, Johansson E, Reynolds AJ, Jolliffe KA, Smith BD.
2006. Synthetic Peptides with Selective Affinity for Apoptotic Cells. Org. Biomol.
Chem 4, 1966 - 1976.
Leevy WM, Gammon ST, Jiang H, Johnson JR, Maxwell DJ, Marquez M,
Piwnica-Worms D, Smith BD. 2006. Optical Imaging of Bacterial Infection in
Living Mice Using a Fluorescent Near-Infrared Molecular Probe. J. Am. Chem
Soc., 128, 16476-16477.
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Leevy WM, Johnson JR, Lakshmi C, Morris J, Marquez M, Smith B D. 2006.
Selective Recognition of Bacterial Membranes by Zinc(II)-Coordination
Complexes. Chem. Comm. 1595-1597.
Hanshaw RG, Smith BD. 2005. New Reagents for Phosphatidylserine
Recognition and Detection of Apoptosis. Bioorg. Med. Chem. 13, 5035-5042.
Hanshaw RG, Lakshmi C, Lambert TN, Smith BD. 2005. Fluorescent Detection
of Apoptotic Cells using a Family of Zinc Coordination Complexes with a
Selective Affinity for Membrane Surfaces that are Enriched with
Phosphatidylserine. ChemBiochem, 12, 2214-2220.
Hanshaw RG, O’Neil EJ, Foley M, Carpenter RT, Smith, BD. 2005. Indicator
Displacement Assays that Detect Bilayer Membranes Enriched in
Phosphatidylserine. J. Materials Chem. 15, 2707-2713
Koulov A V, Hanshaw RG, Stucker KA, Lakshmi C, Smith BD. 2005. Biophysical
Studies of a Synthetic Mimic of the Apoptosis-detecting Protein Annexin V. Israel
J. Chem. 45, 373-379.
Lakshmi C,Hanshaw RG, Smith BD. 2004. Fluorophore Linked Zinc (II)
Dipicolylamine Coordination Complexes as Sensors for Phosphatidylserine
Containing Membranes. Tetrahedron, 60, 11307-11315.
Koulov,AV, Stucker K, Lakshmi C, Robinson J. P., Smith B D. 2003. Detection of
Apoptotic Cells using a Synthetic Fluorescent Sensor for Membrane Surfaces
that Contain Phosphatidylserine. Cell Death Diff., 10, 1357-1359.
Version 7: July 2016