A J OURNAL OF THE AMERICAN D IABETE S A SS OCIATION
August 2016 Volume 65, Number 8
IN THIS ISSUE
METABOLISM
2103 In This Issue of Diabetes
2139 ALOX5AP Overexpression in Adipose Tissue Leads to
LXA4 Production and Protection Against Diet-Induced
Obesity and Insulin Resistance
I. Elias, T. Ferré, L. Vilà, S. Muñoz, A. Casellas, M. Garcia,
M. Molas, J. Agudo, C. Roca, J. Ruberte, F. Bosch, and
S. Franckhauser
PERSPECTIVES IN DIABETES
2105 Thinking Outside the Cell: A Key Role for Hyaluronan
in the Pathogenesis of Human Type 1 Diabetes
M. Bogdani
COMMENTARIES
2115 Untangling the Knot in Diabetic Nephropathy: The
Unanticipated Role of Glycocalyx in the Antiproteinuric
Effect of Endothelin Receptor Antagonists
S. Buelli, L. Perico, and A. Benigni
2118 Endothelium-Derived Hyperpolarizing Factors: A Potential
Therapeutic Target for Vascular Dysfunction in Obesity
and Insulin Resistance
G. Jia, W. Durante, and J.R. Sowers
2121 Defective Invariant Natural Killer T-Cell Suppression in
Patients With Type 1 Diabetes
I. Nel and A. Lehuen
2124 DPP-4 Inhibition and the Known Unknown
M. Horowitz, T. Wu, A.M. Deane, K.L. Jones, and
C.K. Rayner
2127 Uncovering a Mineralocorticoid Receptor–Dependent
Adipose–Vascular Axis: Implications for Vascular
Dysfunction in Obesity?
G. Jia, S.B. Bender, and J.R. Sowers
2130 The Immune Pathogenesis of Type 1 Diabetes: Not Only
Thinking Outside the Cell but Also Outside the Islet and
Out of the Box
H.A. Drexhage, W.A. Dik, P.J.M. Leenen, and M.A. Versnel
TECHNOLOGICAL ADVANCES
2134 CRISPR-Cas9–Mediated Modification of the NOD Mouse
Genome With Ptpn22R619W Mutation Increases
Autoimmune Diabetes
X. Lin, S. Pelletier, S. Gingras, S. Rigaud, C.J. Maine,
K. Marquardt, Y.D. Dai, K. Sauer, A.R. Rodriguez, G. Martin,
S. Kupriyanov, L. Jiang, L. Yu, D.R. Green, and
L.A. Sherman
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2151 A Novel Function of Hepatic FOG2 in Insulin Sensitivity
and Lipid Metabolism Through PPARa
Y. Guo, J. Yu, J. Deng, B. Liu, Y. Xiao, K. Li, F. Xiao, F. Yuan,
Y. Liu, S. Chen, and F. Guo
2164 Renal Denervation for Resistant Hypertension Fails to
Improve Insulin Resistance as Assessed by
Hyperinsulinemic-Euglycemic Step Clamp
A.K. Miroslawska, P.F. Gjessing, M.D. Solbu, O.M. Fuskevåg,
T.G. Jenssen, and T.K. Steigen
2169 Neuronal Deletion of Ghrelin Receptor Almost Completely
Prevents Diet-Induced Obesity
J.H. Lee, L. Lin, P. Xu, K. Saito, Q. Wei, A.G. Meadows,
O.Y.N. Bongmba, G. Pradhan, H. Zheng, Y. Xu, and
Y. Sun
2179 Leptin Substitution in Patients With Lipodystrophy:
Neural Correlates for Long-term Success in the
Normalization of Eating Behavior
H. Schlögl, K. Müller, A. Horstmann, K. Miehle, J. Püschel,
A. Villringer, B. Pleger, M. Stumvoll, and M. Fasshauer
2187 Lipodystrophy Due to Adipose Tissue–Specific Insulin
Receptor Knockout Results in Progressive NAFLD
S. Softic, J. Boucher, M.H. Solheim, S. Fujisaka,
M.-F. Haering, E.P. Homan, J. Winnay, A.R. Perez-Atayde,
and C.R. Kahn
2201 Differential Roles of Insulin and IGF-1 Receptors
in Adipose Tissue Development and Function
J. Boucher, S. Softic, A. El Ouaamari, M.T. Krumpoch,
A. Kleinridders, R.N. Kulkarni, B.T. O’Neill, and C.R. Kahn
2214 Connections Between the Gut Microbiome and Metabolic
Hormones in Early Pregnancy in Overweight and Obese
Women
L.F. Gomez-Arango, H.L. Barrett, H.D. McIntyre,
L.K. Callaway, M. Morrison, and M. Dekker Nitert, for the
SPRING Trial Group
Icons shown below appear on the first page of an article if more
information is available online.
SIGNAL TRANSDUCTION
2224 Insulin-Dependent Regulation of mTORC2-Akt-FoxO
Suppresses TLR4 Signaling in Human Leukocytes:
Relevance to Type 2 Diabetes
Z. Zhang, L.F. Amorosa, S.M. Coyle, M.A. Macor, M.J. Birnbaum,
L.Y. Lee, and B. Haimovich
2235 4E-BP2/SH2B1/IRS2 Are Part of a Novel Feedback Loop
That Controls b-Cell Mass
M. Blandino-Rosano, J.O. Scheys, M. Jimenez-Palomares,
R. Barbaresso, A.S. Bender, A. Yanagiya, M. Liu, L. Rui,
N. Sonenberg, and E. Bernal-Mizrachi
OBESITY STUDIES
2249 Temporal Changes in Skeletal Muscle Capillary
Responses and Endothelial-Derived Vasodilators
in Obesity-Related Insulin Resistance
S.M. Chadderdon, J.T. Belcik, L. Bader, D.M. Peters, P. Kievit,
N.J. Alkayed, S. Kaul, K.L. Grove, and J.R. Lindner
2258 DNA CpG Methylation (5-Methylcytosine) and Its Derivative
(5-Hydroxymethylcytosine) Alter Histone Posttranslational
Modifications at the Pomc Promoter, Affecting the Impact
of Perinatal Diet on Leanness and Obesity of the Offspring
A. Marco, T. Kisliouk, T. Tabachnik, A. Weller, and N. Meiri
2268 CCR7 Maintains Nonresolving Lymph Node and
Adipose Inflammation in Obesity
J. Hellmann, B.E. Sansbury, C.R. Holden, Y. Tang, B. Wong,
M. Wysoczynski, J. Rodriguez, A. Bhatnagar, B.G. Hill, and
M. Spite
2282 Improved Glycemic Control and Vascular Function in
Overweight and Obese Subjects by Glyoxalase 1 Inducer
Formulation
M. Xue, M.O. Weickert, S. Qureshi, N.-B. Kandala, A. Anwar,
M. Waldron, A. Shafie, D. Messenger, M. Fowler, G. Jenkins,
N. Rabbani, and P.J. Thornalley
2295 AMPK Activation by Metformin Suppresses Abnormal
Extracellular Matrix Remodeling in Adipose Tissue and
Ameliorates Insulin Resistance in Obesity
T. Luo, A. Nocon, J. Fry, A. Sherban, X. Rui, B. Jiang, X.J. Xu,
J. Han, Y. Yan, Q. Yang, Q. Li, and M. Zang
ISLET STUDIES
2311 A Glycine-Insulin Autocrine Feedback Loop Enhances
Insulin Secretion From Human b-Cells and Is Impaired in
Type 2 Diabetes
R. Yan-Do, E. Duong, J.E. Manning Fox, X. Dai, K. Suzuki,
S. Khan, A. Bautista, M. Ferdaoussi, J. Lyon, X. Wu, S. Cheley,
P.E. MacDonald, and M. Braun
2322 Human Type 1 Diabetes Is Characterized by an Early, Marked,
Sustained, and Islet-Selective Loss of Sympathetic Nerves
T.O. Mundinger, Q. Mei, A.K. Foulis, C.L. Fligner, R.L. Hull, and
G.J. Taborsky Jr.
2331 Gestational Diabetes Mellitus From Inactivation of
Prolactin Receptor and MafB in Islet b-Cells
R.R. Banerjee, H.A. Cyphert, E.M. Walker, H. Chakravarthy,
H. Peiris, X. Gu, Y. Liu, E. Conrad, L. Goodrich, R.W. Stein, and
S.K. Kim
IMMUNOLOGY AND TRANSPLANTATION
2342 Adrenomedullin 2 Improves Early Obesity-Induced
Adipose Insulin Resistance by Inhibiting the Class II MHC
in Adipocytes
S.-Y. Zhang, Y. Lv, H. Zhang, S. Gao, T. Wang, J. Feng, Y. Wang,
G. Liu, M.-J. Xu, X. Wang, and C. Jiang
2356 Interleukin-13 Pathway Alterations Impair Invariant
Natural Killer T-Cell–Mediated Regulation of Effector
T Cells in Type 1 Diabetes
L. Usero, A. Sánchez, E. Pizarro, C. Xufré, M. Martí,
D. Jaraquemada, and C. Roura-Mir
2367 Deficiency of Nuclear Factor-kB c-Rel Accelerates the
Development of Autoimmune Diabetes in NOD Mice
P. Ramakrishnan, M.A. Yui, J.A. Tomalka, D. Majumdar,
R. Parameswaran, and D. Baltimore
PATHOPHYSIOLOGY
2380 Skeletal Muscle TRIB3 Mediates Glucose Toxicity in
Diabetes and High-Fat Diet–Induced Insulin Resistance
W. Zhang, M. Wu, T. Kim, R.H. Jariwala, W.J. Garvey, N. Luo,
M. Kang, E. Ma, L. Tian, D. Steverson, Q. Yang, Y. Fu, and
W.T. Garvey
2392 Adipocyte-Specific Mineralocorticoid Receptor
Overexpression in Mice Is Associated With Metabolic
Syndrome and Vascular Dysfunction: Role of
Redox-Sensitive PKG-1 and Rho Kinase
A. Nguyen Dinh Cat, T.T. Antunes, G.E. Callera, A. Sanchez,
S. Tsiropoulou, M.G. Dulak-Lis, A. Anagnostopoulou, Y. He,
A.C. Montezano, F. Jaisser, and R.M. Touyz
2404 Functional Brain Networks Are Altered in Type 2 Diabetes
and Prediabetes: Signs for Compensation of Cognitive
Decrements? The Maastricht Study
F.C.G. van Bussel, W.H. Backes, T.M. van Veenendaal,
P.A.M. Hofman, M.P.J. van Boxtel, M.T. Schram, S.J.S. Sep,
P.C. Dagnelie, N. Schaper, C.D.A. Stehouwer, J.E. Wildberger, and
J.F.A. Jansen
COMPLICATIONS
2414 Essential Role of Transglutaminase 2 in Vascular
Endothelial Growth Factor–Induced Vascular Leakage in
the Retina of Diabetic Mice
Y.-J. Lee, S.-H. Jung, S.-H. Kim, M.-S. Kim, S. Lee, J. Hwang,
S.-Y. Kim, Y.-M. Kim, and K.-S. Ha
PHARMACOLOGY AND THERAPEUTICS
2429 Atrasentan Reduces Albuminuria by Restoring the
Glomerular Endothelial Glycocalyx Barrier in Diabetic
Nephropathy
M.G.S. Boels, M.C. Avramut, A. Koudijs, M.J.C. Dane,
D.H. Lee, J. van der Vlag, A.J. Koster, A.J. van Zonneveld,
E. van Faassen, H.-J. Gröne, B.M. van den Berg, and
T.J. Rabelink
2440 Quantification of the Contribution of GLP-1 to Mediating
Insulinotropic Effects of DPP-4 Inhibition With
Vildagliptin in Healthy Subjects and Patients With Type 2
Diabetes Using Exendin [9-39] as a GLP-1 Receptor
Antagonist
M.A. Nauck, J. Kind, L.D. Köthe, J.J. Holst, C.F. Deacon,
M. Broschag, Y.L. He, L. Kjems, and J. Foley
GENETICS/GENOMES/PROTEOMICS/METABOLOMICS
2448 Genetic Evidence for a Link Between Favorable Adiposity
and Lower Risk of Type 2 Diabetes, Hypertension, and
Heart Disease
H. Yaghootkar, L.A. Lotta, J. Tyrrell, R.A.J. Smit, S.E. Jones,
L. Donnelly, R. Beaumont, A. Campbell, M.A. Tuke, C. Hayward,
K.S. Ruth, S. Padmanabhan, J.W. Jukema, C.C. Palmer,
A. Hattersley, R.M. Freathy, C. Langenberg, N.J. Wareham,
A.R. Wood, A. Murray, M.N. Weedon, N. Sattar, E. Pearson,
R.A. Scott, and T.M. Frayling
EXPRESSIONS OF CONCERN
STATEMENT OF RETRACTION
2461 Expression of Concern. Transcription Factor 7-Like
2 Regulates b-Cell Survival and Function in Human
Pancreatic Islets. Diabetes 2008;57:645–653.
DOI: 10.2337/db07-0847; and erratum. Diabetes
2014;63:3974. DOI: 10.2337/db14-er11
L. Shu, N.S. Sauter, F.T. Schulthess, A.V. Matveyenko,
J. Oberholzer, and K. Maedler
2463 Statement of Retraction. Hepatic Glucagon Action Is
Essential for Exercise-Induced Reversal of Mouse Fatty Liver.
Diabetes 2011;60:2720–2729. DOI: 10.2337/db11-0455
E.D. Berglund, D.G. Lustig, R.A. Baheza, C.M. Hasenour,
R.S. Lee-Young, E.P. Donahue, S.E. Lynes, L.L. Swift,
M.J. Charron, B.M. Damon, and D.H. Wasserman
2462 Expression of Concern. Low Concentration of
Interleukin-1b Induces FLICE-Inhibitory Protein–
Mediated b-Cell Proliferation in Human Pancreatic Islets.
Diabetes 2006;55:2713–2722; DOI: 10.2337/db05-1430
K. Maedler, D.M. Schumann, N. Sauter, H. Ellingsgaard, D. Bosco,
R. Baertschiger, Y. Iwakura, J. Oberholzer, C.B. Wollheim,
B.R. Gauthier, and M.Y. Donath
2464 Issues and Events
ISSUES AND EVENTS
e-LETTERS – COMMENTS AND RESPONSES
e28
Comment on Alarcon et al. Pancreatic b-Cell Adaptive
Plasticity in Obesity Increases Insulin Production but Adversely
Affects Secretory Function. Diabetes 2016;65:438–450
J.P. Little and É. Myette-Côté
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On the cover: An original microscopic image of a mouse pancreas stained with hematoxylin and eosin. The image in the middle that looks like
a standing chicken is actually the pancreatic duct of a NOD mouse surrounded by acinar cells. The image above the pancreatic duct is of islet cells.
Credit: Parameswaran Ramakrishnan. This issue of Diabetes features the article “Deficiency of Nuclear Factor-kB c-Rel Accelerates the Development of
Autoimmune Diabetes in NOD Mice” by Ramakrishnan et al. (p. 2367).