1
Michael F. Smith
Professor, Animal Science
University of Missouri-Columbia
Personal Information:
Office Address:
Division of Animal Science
160 Animal Sciences Center
University of Missouri
Columbia, MO 65211
Phone: 573-882-8239
Fax: 573-884-7827
E-mail: smithmf@missouri.edu
Education:
University Attended
Degree
Year
Area of Specialization
Colorado State University
Texas A&M University
Texas A&M University
B.S.
M.S.
Ph.D.
1974
1976
1980
Animal Science
Physiology of Reproduction
Physiology of Reproduction
Area of Expertise: Reproductive Physiology with emphasis on ovarian function in ruminants
Employment History:
2006-Present
Professor, Division of Animal Sciences, University of Missouri-Columbia.
2001 – 2006
Interim Director, Division of Animal Sciences, University of MissouriColumbia.
1990-2001
Professor, Animal Sciences Department, University of Missouri-Columbia
1996-1997
Visiting Scientist, Department of Development and
Reproduction, Roslin Institute (Edinburgh), Roslin, Midlothian, United Kingdom
1988-1990
Associate Professor, Animal Sciences Department, University of Missouri-Columbia
1987-1988
Visiting Scientist, Department of Molecular Embryology, AFRC
Institute of Animal Physiology and Genetics Research, Babraham, Cambridge,
United Kingdom
1986-1987
Associate Professor, Animal Sciences Department, University of Missouri-Columbia
1980-1986
Assistant Professor, Animal Sciences Department, University of Missouri-Columbia
1978-1980
Graduate Assistant, Texas A&M University
1977-1978
Research Associate, Texas Agricultural Experiment Station, Beeville
1975-1977
Graduate Assistant, Texas A&M University
1975
Research Technician, Texas Agricultural Experiment Station, Beeville
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Professional Organizations:
American Society of Animal Science
Society for the Study of Reproduction
Society for Reproduction and Fertility
National Cattlemen’s Beef Association
Missouri Cattlemen’s Association
Editorial Board:
Domestic Animal Endocrinology - 1993-1996
Reproduction – 2001-present
Awards:
American Society of Animal Science Scholastic Award, 1974.
Gamma Sigma Delta Graduate Teaching Award, 1987.
Gamma Sigma Delta Junior Research Award, 1989.
Midwest Section American Society of Animal Science Young Animal Scientist Research Award, 1991.
College of Agriculture Green Chalk Award (Undergraduate Teaching), 1991.
College of Agriculture Undergraduate Teaching Award, 1993.
National Association of Colleges and Teachers of Agriculture Teaching Award of Merit 1993.
William T. Kemper Fellowship for Teaching Excellence, 1995.
Gamma Sigma Delta Senior Research Award, 2001.
College of Agriculture, Food and Natural Resources Research Award, 2003.
Frederick B. Mumford Outstanding Faculty Award 2004.
College of Agriculture, Food and Natural Resources Teaching Academy, 2005.
Society for the Study of Reproduction Trainee Mentoring Award, 2008.
University of Missouri Graduate Student Mentoring Award, 2008.
American Society of Animal Science Distinguished Teaching Award, 2008.
Maxine Christopher Shutz Award for Distinguished Teaching, 2008.
American Society of Animal Science Physiology and Endocrinology Award, 2009.
Mizzou Alumni Association Distinguished Faculty Award, 2009
USDA Regional Teaching Award, 2010
RESEARCH ACTIVITIES
Research Program:
An improved understanding of the hormonal interrelationships among the hypothalamus, pituitary
gland, and ovary is needed in efforts to increase reproductive efficiency of livestock. More specifically,
the development of improved and economical methods of controlling livestock reproduction depends
upon an increased understanding of the physiological mechanisms regulating ovarian function. In beef
and dairy cows, the maturation of an ovarian follicle culminating in ovulation and formation of a normal
corpus luteum is a process that is poorly understood. Problems such as delayed puberty, cystic ovaries,
and prolonged postpartum intervals have been attributed to follicular development that is not
accompanied by ovulation. The economic impact of prolonged postpartum intervals has been
documented. Estimates by the USDA indicate that a 6 day decrease in postpartum interval length would
reduce cow maintenance costs by $112 million and the increased calf weaning weights would be worth
$96 million.
3
Dr. Smith's research program has focused on mechanisms associated with follicular development
culminating in the release of a fertilizable germ cell and formation of a corpus luteum. The goal of his
research studies is to better understand extraovarian and intraovarian mechanisms regulating follicular
maturation and corpus luteum function. A deeper understanding of the mechanisms should result in the
development of improved methods of controlling reproductive events (e.g., decreasing postpartum
interval length and improving the synchronization of ovulation).
Refereed Journal Articles:
1.
Smith, M.F., W.C. Burrell, L.D. Shipp, L.R. Sprott, W.N. Songster and J.N. Wiltbank. 1979.
Hormone treatments and use of calf removal in postpartum beef cows. J. Anim. Sci. 48:12851294.
2.
Smith, M.F., W.C. Burrell, J. Broadway and J.N. Wiltbank. 1979. Estrus and pregnancy in beef
heifers following use of Syncro-Mate-B treatment (SMB). Theriogenology 12:183-195.
3.
Smith, M.F., L.D. Shipp, W.N. Songster, J.N. Wiltbank and L.H. Carroll. 1980. Effect of
monensin, energy level, and cow body condition on pregnancy rate in nonlactating beef cows.
Theriogenology 14:91-104.
4.
Smith, M.F., R.E. Owens, T.A. Fitz, J.L. Fleeger and P.G. Harms. 1981. The effect of
exogenous steroids and/or a dopaminergic receptor agonist on plasma luteinizing hormone
concentration in ovariectomized rats. IRCS Med. Sci. 9:65.
5.
Smith, M.F., D.L. Morris, M.S. Amoss, N.R. Parish, J.D. Williams and J.N. Wiltbank. 1981.
Relationships among fertility, scrotal circumference, seminal quality, and libido in Santa
Gertrudis bulls. Theriogenology 16:379-397.
6.
Morris, J.S., M.F. Smith, R.E. Morrow, E.D. Heimann, J.C. Hancock and T. Gall. 1982. INAA
determination of selenium via 77mSe in plasma, semen and hair samples from beef and dairy bulls.
J. Radioanalytical Chem. 69:473-494.
7.
Smith, M.F., K.J. Nix, D.C. Kraemer, M.S. Amoss, M.A. Herron and J.N. Wiltbank. 1982.
Fertilization rate and early embryonic loss in Brahman crossbred heifers. J. Anim. Sci. 54:10051011.
8.
Heimann, E.D., M.F. Smith, J.S. Morris, T.J. Gall, R.G. Elmore and R.E. Morrow. 1982.
Seminal selenium concentrations and spermatozoal abnormalities in beef bulls. Theriogenology
18:297-302.
9.
Walters, D.L., M.F. Smith, P.G. Harms and J.N. Wiltbank. 1982. Effect of steroids and/or 48 hr
calf removal on serum luteinizing hormone concentrations in anestrous beef cows.
Theriogenology 18:349-356.
10.
Huang, R., M.F. Smith and W.L. Zahler. 1982. Inhibition of forskolin-activated adenylate
cyclase by ethanol and other solvents. J. Cyclic Nucleotide Res. 8:385-394.
11.
Smith, M.F., A.W. Lishman, G.S. Lewis, P.G. Harms, M.R. Ellersieck, E.K. Inskeep, J.N.
Wiltbank and M.S. Amoss. 1983. Pituitary and ovarian response to gonadotropin releasing
hormone, calf removal and progestogen in anestrous beef cows. J. Anim. Sci. 57:418-424.
4
12.
Heimann, E.D., M.F. Smith, J.S. Morris, T.J. Gall, R.G. Elmore and R.E. Morrow. 1984.
Relationship among spermatozoal abnormalities and the selenium concentration of blood plasma,
semen and reproductive tissue in young bulls. Anim. Reprod. Sci. 7:315-321.
13.
Agudo, L.Sp., W.L. Zahler and M.F. Smith. 1984. Effect of prostaglandin F2 on the adenylate
cyclase and phosphodiesterase activity of ovine corpora lutea. J. Anim. Sci. 58:955-962.
14.
Smith, M.F., R.L. Russell, T.J. Gall and D.W. Vogt. 1984. Comparison of the two methods for
estrous synchronization of two year old beef cows. 10th Int. Cong. Anim. Reprod. Artif. Insem.
3:350-352.
15.
Smith, M.F., L.Sp. Agudo and B.D. Schanbacher. 1984. Follicle stimulating hormone secretion
and compensatory ovarian hypertrophy in prepubertal ewes. Theriogenology 21:969-979.
16.
Johnson, S.K., M.F. Smith and R.G. Elmore. 1985. Effect of unilateral ovariectomy and
injection of bovine follicular fluid on gonadotropin secretion and compensatory ovarian
hypertrophy in prepuberal heifers. J. Anim. Sci. 60:1055-1060.
17.
Dunn, R.T., Jr., M.F. Smith, H.A. Garverick and C.W. Foley. 1985. Effects of 72 hr calf
removal and/or gonadotropin releasing hormone on luteinizing hormone release and ovarian
activity in postpartum beef cows. Theriogenology 23:767-776.
18.
Johnson, S.K. and M.F. Smith. 1985. Effects of charcoal extracted, bovine follicular fluid on
gonadotropin concentrations, the onset of estrus and luteal function in heifers. J. Anim. Sci.
61:203-209.
19.
Garverick, H.A., M.F. Smith, R.G. Elmore, G.L. Morehouse, L.Sp. Agudo and W.L. Zahler.
1985. Changes and interrelationships among luteal LH receptors, adenylate cyclase activity and
phosphodiesterase activity during the bovine estrous cycle. J. Anim. Sci. 61:216-223.
20.
Smith, M.F. 1986. Recent advances in corpus luteum physiology. J. Dairy Sci. 69:911-926.
21.
Garverick, H.A. and M.F. Smith. 1986. Mechanisms associated with subnormal luteal function.
J. Anim. Sci. 62(Suppl. 2):92-105.
22.
Smith, M.F., H.A. Garverick, R.S.Youngquist and W.L. Zahler. 1986. Luteinizing hormone
receptor concentrations, adenylate cyclase activity and phosphodiesterase activity of bovine
corpora lutea: Comparison of short and normal estrous cycles. Domest. Anim. Endocrinol.
3(2):127-133.
23.
Smith, M.F., H.A. Swartz, D.O. Kiesling and J.E. Warren, Jr. 1986. Effect of ram exposure and
prostaglandin F2 alpha on the reproductive performance of anestrous ewes. Theriogenology
26:829-835.
24.
Copelin, J.P., M.F. Smith, H.A. Garverick and R.S. Youngquist. 1987. Effect of the uterus on
subnormal luteal function in anestrous beef cows. J. Anim. Sci. 64:1506-1511.
25.
Nakamura, Y., M. Smith, A. Krishna and P.F. Terranova. 1987. Increased number of mast cells
in the dominant follicle of the cow: Relationships among luteal, stromal, and hilar regions. Biol.
Reprod. 37:546-549.
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26.
Garverick, H.A., J.R. Parfet, C.N. Lee, J.P. Copelin, R.S. Youngquist and M.F. Smith. 1988.
Relationship of pre- and postovulatory gonadotropin concentration to subnormal luteal function
in postpartum beef cattle. J. Anim. Sci. 66:104-111.
27.
Copelin, J.P., M.F. Smith, H.A. Garverick, R.S. Youngquist, W.R. McVey, Jr. and E.K. Inskeep.
1988. Responsiveness of bovine corpora lutea to prostaglandin F2: Comparison of corpora lutea
anticipated to have short or normal lifespans. J. Anim. Sci. 66:1236-1245.
28.
Copelin, J.P., M.F. Smith, H.A. Garverick and R.S. Youngquist. 1989. Effect of abortion or long
term progestogen exposure on subsequent estrous cycle length and concentration of progesterone
in plasma of heifers. J. Anim. Sci. 67:1552-1558.
29.
Moser, M.T., H.A. Garverick, M.F. Smith and R.S. Youngquist. 1989. Follicular growth and
endocrine patterns of prepuberal heifers administered bovine follicular fluid and(or) follicle
stimulating hormone. Anim. Reprod. Sci. 18:227-242.
30.
Zollers, W.G., D.W. Forrest, W.J. Campbell, J.R. Parfet, M.F. Smith, P.G. Harms and H.A.
Garverick. 1989. Ovarian inhibition of follicle stimulating hormone secretion in prepuberal
Holstein heifers. Domest. Anim. Endocrinol. 6:35-40.
31.
Moser, M.T., H.A. Garverick, M.F. Smith and R.S. Youngquist. 1989. Effect of bovine
follicular fluid and(or) follicle stimulating hormone on follicular growth in unilaterally
ovariectomized prepuberal heifers. J. Dairy Sci. 72:2170-2178.
32.
Zollers, W.G., Jr., H. A. Garverick and M.F. Smith. 1989. Oxytocin-induced release of
prostaglandin F2 in postpartum beef cows: Comparison of short versus normal luteal phases.
Biol. Reprod. 41:262-267.
33.
Copelin, J.P., M.F. Smith, D.H. Keisler and H.A. Garverick. 1989. Effect of active
immunization of prepartum and postpartum cows against prostaglandin F2 on lifespan and
progesterone secretion of short-lived corpora lutea. J. Reprod. Fertil. 87:199-207.
34.
Caldwell, R.W., J.C. Whittier, M.F. Smith, R.E. Morrow and R.V. Anthony. 1990. Parturition in
beef cows following administration of porcine relaxin at ten days prepartum. Theriogenology
33:613-625.
35.
Hamilton, S.A., R.E. Raw, M.F. Smith and H.A. Garverick. 1990. Effect of a lipoxygenase
inhibitor on luteal lifespan and on oxytocin-induced release of prostaglandin F2 in heifers. J.
Dairy Sci. 73:2350-2354.
36.
Smith, M.F. and R.M. Moor. 1991. Secretion of a putative metalloproteinase inhibitor by ovine
granulosa cells and luteal tissue. J. Reprod. Fertil. 91:627-635.
37.
Zollers, W.G., Jr., H.A. Garverick, R.S. Youngquist, J.S. Ottobre, R.W. Silcox, J.P. Copelin and
M.F. Smith. 1991. In vitro secretion of prostaglandins from endometrium of postpartum beef
cows expected to have short or normal luteal phases. Biol. Reprod. 44:522-526.
38.
Lutz, S.L., M.F. Smith, D.H. Keisler and H.A. Garverick. 1991. Effect of constant infusion of
oxytocin on luteal lifespan and oxytocin-induced release of prostaglandin F2 in heifers.
Domestic Animal Endocrinology 8(4):573-585.
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39.
Whittier, J.C., R.W. Caldwell, R.V. Anthony, M.F. Smith and R.E. Morrow. 1991. Effect of a
prostaglandin F2 injection 96 hours after introduction of intact bulls on estrus and calving
distribution of beef cows. J. Anim. Sci. 69:4670-4677.
40.
Garverick, H.A., M.T. Moser, D.H. Keisler, S.A. Hamilton, R.M. Roberts and M.F. Smith. 1992.
Luteal function following intrauterine infusion of recombinant bovine interferon-I1 into
postpartum beef cows anticipated to have short or normal luteal phases. J. Reprod. Fertil. 94:319325.
41.
Garverick, H.A., W.G. Zollers, Jr. and M.F. Smith. 1992. Mechanisms associated with corpus
luteum lifespan in animals having normal or subnormal luteal function. Anim. Reprod. Sci.
28:111-124.
42.
Plata-Madrid, H., W.E. Loch, R.S. Youngquist, D.L. Thompson, Jr., K.G. Bennett-Wimbush, C.
Wilkerson, G. Bouchard, M.F. Smith, W.F. Braun and J.J. Aveiro. 1992. Control of FSH,
follicular development and estrous synchronization in the mare with steroid-free follicular fluid.
Theriogenology 37:817-838.
43.
Smith, G.W., R.M. Moor and M.F. Smith. 1993. Identification of a 30,000 Mr polypeptide
secreted by cultured ovine granulosa cells and luteal tissue as a tissue inhibitor of
metalloproteinases. Biol. Reprod. 48:125-132.
44.
Juengel, J.L., H.A. Garverick, A.L. Johnson, R.S. Youngquist and M.F. Smith. 1993. Apoptosis
during luteal regression in cattle. Endocrinology 132:249-254.
45.
Moffatt, R.J., W.G. Zollers, Jr., W.V. Welshons, K.R. Kieborz, H.A. Garverick and M.F. Smith.
1993. Basis of norgestomet action as a progestogen in cattle. Domest. Anim. Endocrinol. 10:2130.
46.
Zollers, W.G., Jr., H.A. Garverick, M.F. Smith, R.J. Moffatt, B.E. Salfen and R.S. Youngquist.
1993. Concentrations of progesterone and oxytocin receptors in endometrium of postpartum
cows expected to have a short or normal oestrous cycle. J. Reprod. Fertil. 97:329-337.
47.
Juengel, J.L., K. Imakawa, P.W. Farin, R.S. Youngquist, R.M. Roberts, M.F. Smith and H.A.
Garverick. 1993. Detection of mRNA for inhibin - and A-subunits in bovine ovarian tissues
and the effect on in vivo administration of GnRH. Domest. Anim. Endocrinol. 10:207-218.
48.
Juengel, J.L., G.W. Smith, M.F. Smith, R.S. Youngquist and H.A. Garverick. 1994. Pattern of
protein production by bovine corpora lutea during luteolysis and characterization of expression of
two major secretory products of regressing corpora lutea. J. Reprod. Fertil. 100:515-520
49.
Garverick, H.A. and M.F. Smith. 1993. Female reproductive physiology and endocrinology of
cattle. Vet Clinics of North America: Feed Animal Practice. Vol 9:223-247.
50.
Smith, G.W., T.L. Goetz, R.V. Anthony and M.F. Smith. 1994. Molecular cloning of an ovine
tissue inhibitor of an ovarian tissue inhibitor of metalloproteinases (TIMP-1): Ontogeny of
mRNA expression and in situ localization within preovulatory follicles and luteal tissue.
Endocrinology 134:344-352.
51.
Smith, M.F., E.W. McIntush and G.W. Smith. 1994. Mechanisms associated with corpus luteum
development. J. Anim. Sci. 72:1857-1872.
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52.
Smith, M.F., C.N. Kemper, G.W. Smith, T.L. Goetz and V.L. Jarrell. 1994. Production of tissue
inhibitor of metalloproteinases-1 by porcine follicular and luteal cells. J. Anim. Sci. 72:10041012.
53.
Xu, Z., H.A. Garverick, G.W. Smith, M.F. Smith, S.A. Hamilton and R.S. Youngquist. 1995.
Expression of messenger RNA encoding cytochrome P450 side chain cleavage, cytochrome P450
17 hydroxylase, and cytochrome P450 aromatase in bovine follicles during the first follicular
wave. Endocrinology 136 (3):981-989.
54.
Smith, G.W., S. McCrone, S.L. Petersen and M.F. Smith. 1995. Expression of messenger RNA
encoding tissue inhibitor of metalloproteinases-2 (TIMP-2) within ovine follicles and corpora
lutea. Endocrinology 136 (2):570-576.
55.
Anthony, R.V., G.W. Smith, A. Duong, S.L. Pratt and M.F. Smith. 1995. Two forms of the
prolactin receptor messenger ribonucleic acid are present in ovine fetal liver and adult ovary.
Endocrine 3:291-295.
56.
Xu, Z.Z., H.A. Garverick, G.W. Smith, M.F. Smith, S.A. Hamilton, and R.S. Youngquist. 1995.
Expression of follicle-stimulating hormone and luteinizing hormone receptor messenger
ribonucleic acids in bovine follicles during the first follicular wave. Biol. Reprod. 53:951-957.
57.
Salfen, B.E., D.H. Keisler, M.F. Smith, W.G. Zollers, Jr., K.R. Kieborz-Loos and H.A.
Garverick. 1995. Effect of intrauterine infusion of recombinant bovine interferon I1 on luteal
phase duration and oxytocin-induced release of 13,14-dihydro-15-keto-prostaglandin F2 in
postpartum beef cows. Anim. Reprod. Sci. 40:193- 201.
58.
Smith, G.W., P.C. Gentry, R.M. Roberts and M.F. Smith. 1996. Ontogeny and regulation of
luteinizing hormone receptor messenger ribonucleic acid expression within the ovine corpus
luteum. Biol. Reprod. 54:76- 83.
59.
Smith, G.W., J.L. Juengel, E.W. McIntush, R.S. Youngquist, H.A. Garverick and M.F. Smith.
1996. Ontogenies of messenger RNA encoding tissue inhibitor of metalloproteinases 1 and 2
within bovine periovulatory follicles and luteal tissue. Dom. Anim. Endo. 13 (2):151-160.
60.
Smith, G.W., P.C. Gentry, D.K. Long, M.F. Smith and R.M. Roberts. 1996. Differential gene
expression within the ovine corpus luteum: Identification of secreted protein acidic and rich in
cysteine (SPARC) as a major secretory product of small but not large luteal cells. Endocrinology
137:755-762.
61.
Gentry, P.C., G.W. Smith, R.V. Anthony, Z. Zhang, D.K. Long and M.F. Smith. 1996.
Characterization of ovine stem cell factor messenger ribonucleic acid and protein in the corpus
luteum throughout the luteal phase. Biol. Reprod. 54:970-979
62.
McIntush, E.W., J.D. Pletz, G.W. Smith, D.K. Long, H.R. Sawyer and M.F. Smith. 1996.
Immunolocalization of tissue inhibitor of metalloproteinases (TIMP-1) within ovine periovulatory
follicular and luteal tissues. Biol. Reprod. 54:871-878.
63.
Yuan, W., M.C. Lucy and M.F. Smith. 1996. Messenger ribonucleic acid for insulin-like growth
factors-I and II, insulin-like growth factor binding protein-2, gonadotropin receptors, and
steroidogenic enzymes in porcine follicles. Biol. Reprod. 55:1045-1054.
64.
Kirby, C.J., M.F. Smith, D.H. Keisler and M.C. Lucy. 1997. Follicular function in lactating
dairy cows treated with sustained-release bovine somatotropin. J. Dairy Sci. 80:273-285.
8
65.
Niswender, K.D., J. Li, M.R. Powell, K.R. Loos, R.M. Roberts, D.H. Keisler and M.F. Smith.
1997. Effect of variants of interferon- with mutations near the carboxyl terminus on luteal life
span in sheep. Biol. Reprod. 56:214-220.
66.
Bao, B., H.A. Garverick, G.W. Smith, M.F. Smith, B.E. Salfen and R.S. Youngquist. 1997.
Expression of messenger ribonucleic acid (mRNA) encoding 3-hydroxysteroid dehydrogenase
4,5 isomerase (3-HSD) during recruitment and selection of bovine ovarian follicles:
Identification of dominant follicles by expression of 3-HSD mRNA within the granulosa cell
layer. Biol. Reprod. 56:1466-1473.
67.
Bao, B., H.A. Garverick, G.W. Smith, M.F. Smith, B.E. Salfen and R.S. Youngquist. 1997.
Changes in messenger ribonucleic acid encoding luteinizing hormone receptor, cytochrome P450side chain cleavage, and aromatase are associated with recruitment and selection of bovine
ovarian follicles. Biol. Reprod. 56:1158-1168.
68.
Buhi, W.C., I.M. Alvarez, A.R. Pickard, E.W. McIntush, A.J. Kouba, C.J. Ashworth and M.F.
Smith. 1997. Expression of tissue inhibitor of metalloproteinase-1 protein and messenger
ribonucleic acid by the oviduct of cyclic, early-pregnant, and ovariectomized steroid-treated gilts.
Biol. Reprod. 57:7-15.
69.
Smith, G.W., P.C. Gentry, B. Bao, D.K. Long, R.M. Roberts and M.F. Smith. 1997. Control of
extracellular matrix remodelling within ovarian tissues: localization and regulation of
plasminogen activator inhibitor type-1 (PAI-1) gene expression within the ovine corpus luteum.
J. Reprod. Fertil. 110:107-114.
70.
McIntush, E.W., D.H. Keisler and M.F. Smith. 1997. Concentration of tissue inhibitor of
metalloproteinases (TIMP-1) in ovine follicular fluid and serum. J. Anim. Sci. 75:3255-3261.
71.
Gentry, P.C., G.W. Smith, D.R. Leighr, B. Bao and M.F. Smith. 1998. Ontogeny of stem cell
factor receptor (c-kit) mRNA in the ovine corpus luteum. Biol. Reprod. 59:983-990.
72.
Juengel, J.L., B.M. Meberg, E.W. McIntush, M.F. Smith and G.D. Niswender. 1998.
Concentration of mRNA encoding 3-hydroxysteroid dehydrogenase/5,4 isomerase (3-HSD)
and 3 enzyme activity following treatment of ewes with prostaglandin F2. Endocrine 8:45-50.
73.
Bao, B., M.D. Calder, S. Xie, M.F. Smith, B.E. Salfen, R.S. Youngquist and H.A. Garverick.
1998. Expression of steroidogenic acute regulatory protein messenger ribonucleic acid is limited
to theca of healthy bovine follicles collected during recruitment, selection, and dominance of
follicles of the first follicular wave. Biol. Reprod. 59:953-959.
74.
McIntush, E.W. and M.F. Smith. 1998. Matrix metalloproteinases and tissue inhibitors of
metalloproteinases in ovarian function. Rev. Repro. 3:23-30.
75.
Smith, M.F., E.W. McIntush, W.A. Ricke, F.N. Kojima and G.W. Smith. 1998. Regulation of
ovarian extracellular matrix remodeling by metalloproteinases and their tissue inhibitors: Effects
on follicular development, ovulation, and luteal function. J. Reprod. Fertil. Suppl. 54:367-381.
76.
Whittier, J.C., B.N. Weech, M.C. Lucy, D.H. Keisler, M.F. Smith and R.M. Corwin. 1999.
Effect of anthelmintic treatment on sexual maturation in prepubertal beef heifers. J. Anim. Sci.
77:736-741.
9
77.
Funahashi, H., E.W. McIntush, M.F. Smith and B.N. Day. 1999. The presence of tissue inhibitor
of matrix metalloproteinases-1 (TIMP-1) during meiosis improves porcine ‘oocyte competence’
as determined by early embryonic development after in vitro fertilization. J. Reprod. Dev.
45:265-271.
78.
Rosenfeld, C.S., A.A. Murray, G. Simmer, M.G. Hufford, M.F. Smith, N. Spears and D.B.
Lubahn. 2000. Gonadotropin induction of ovulation and corpus luteum formation in young
estrogen receptor- knockout mice. Biol. Reprod. 62:599-605.
79.
Kojima, F.N., B.E. Salfen, J.F. Bader, W.A. Ricke, M.C. Lucy, M.F. Smith and D.J. Patterson.
2000. Development of an estrous synchronization protocol for beef cattle with short-term feeding
of melengestrol acetate: 7-11 synch. J. Anim. Sci. 78: 2186-2191.
80.
Strauch, T.A., E.J. Scholljegerdes, D.J. Patterson, M.F. Smith, M.C. Lucy, W.R. Lamberson, and
J.E. Williams, 2001. Influence of undegraded intake protein on reproductive performance of
primaporous beef heifers maintained on stockpiled fescue pasture. J. Anim. Sci. 79:574-581.
81.
Murray, A.A., M.D. Molinek, S.J. Baker, F.N. Kojima, M.F. Smith, S.G. Hillier and N. Spears.
2001. Role of ascorbic acid in promoting follicle integrity and survival in intact mouse ovarian
follicles in vitro. Reproduction 121:89-96.
82.
Levy, N., M. Gordin, R. Mambik,, M. Yanagisawa, M.F. Smith, J.H. Hampton and R. Meidan.
2001. Distinct cellular localization and regulation of endothelen-1 and endothelen-converting
enzyme and expression in the bovine corpus luteum: Implications for luteolysis. Endocrinology
142:5254-5260.
83.
Wood, S.L., M.C. Lucy, M.F. Smith, D.J. Patterson. 2001. Improved synchrony of estrus and
ovulation with addition of GnRH to a melengestrol acetate-prostaglandin F2 estrus
synchronization treatment in beef heifers. J. Anim. Sci 79:2210-2216.
84.
Burke, J.M., D.E. Spiers, F.N. Kojima, G.A. Perry, B.E. Salfen, S.L. Wood, D.J. Patterson, M.F.
Smith, M.C. Lucy, W.G. Jackson and E.L. Piper. 2001. Interaction of endophye-infected fescue
and heat stress on ovarian function in the beef heifer. Biol. Repro. 65:260-268.
85.
Salfen, B.E., F.N. Kojima, J.F. Bader, M.F. Smith and H.A. Garverick. 2001. Effect of shortterm calf removal at three stages of a follicular wave on fate of a dominant follicle in postpartum
beef cows. J. Anim. Sci. 79:2688-2697.
86.
Ricke, W.A., G.W. Smith, E.W. McIntush, M.F. Smith. 2002. Analysis of Luteal Tissue
Inhibitor of Metalloproteinases (TIMP)-1,-2, and -3 During Prostaglandin F2 -Induced
Luteolysis. Biol Reprod. 66:1387-1394.
87.
Ricke, W.A., G.W. Smith, L.P. Reynolds, D.A. Redmer and M.F. Smith. 2002. Matrix
metalloproteinase (2, 9, and 14) expression, localization, and activity in ovine corpora lutea
throughout the estrous cycle. Biol. Reprod. 66:1083-1094.
88.
Ricke, W.A., G.W. Smith and M.F. Smith. 2002. Matrix metalloproteinase expression and
activity following prostaglandin F2-induced luteolysis. Biol. Reprod. 66:685-691.
89.
Smith, M.F., W.A. Ricke, L.J. Bakke, M.P.D. Dow and G.W. Smith. 2002. Ovarian tissue
remodeling: Role of matrix metalloproteinases and their inhibitors. Molecular Cellular
Endocrinology 191:45-56.
10
90.
Peters, M.W., M.F. Smith, and G.W. Smith. 2002. Use of critical interactive thinking exercises
in teaching reproductive physiology to undergraduate students. J. Anim. Sci. 80:862-865.
91.
Perry, G.A., F.N. Kojima, B.E. Salfen, J.F. Bader, D.J. Patterson and M.F. Smith. 2002. Effect
of an orally active progestin on follicular dynamics in cycling and anestrous postpartum beef
cows. J. Anim. Sci. 80:1932-1938.
92.
Perry, G.A., M. F. Smith, and D.J. Patterson. 2002. Evaluation of fixed-time artificial
insemination protocol for postpartum suckled beef cows. J. Anim. Sci 80:3060-3064.
93.
Mao, J., G. Wu, M.F. Smith, T.C. McCauley, T.C. Cantley, R.S. Prather, B.A. Didion, and B.N.
Day. 2002. Effects of culture medium, serum type, and various concentrations of folliclestimulating hormone on porcine preantral follicular development and antrum formation in vitro.
Biology of Reproduction 67:1197-1203.
94.
Levy, N., M. Gordin, M.F. Smith, O. Bolden-Tiller, and R. Meidan. 2003. Hormonal regulation
and cell-specific expression of endothelin converting enzyme-1 isoforms in bovine ovarian
endothelial and steroidogenic cells. Biol. Reprod. 68: 1361-1368.
95.
Kieborz-Loos, K.R., H.A. Garverick, D.H. Keisler, S.A. Hamilton, B.E. Salfen, R.S. Youngquist
and M.F. Smith. 2003. Oxytocin-Induced release of prostaglandin F2α in postpartum beef cows:
Effects of progesterone and estradiol-17β treatment. J. Animal Sci 81:1830-1836.
96.
Patterson, D.J., F.N. Kojima, and M.F. Smith. 2003. Symposium paper: Methods to
synchronize estrous cycles of postpartum beef cows with melengestrol acetate. Professional
Animal Scientist. 19:109-115.
97.
Patterson, D.J., F.N. Kojima, and M.F. Smith. 2003. A review of methods to synchronize estrus
in replacement beef heifers and postpartum cows. J. Anim. Sci. 81 (E. Suppl 2) E166-E177.
98.
Patterson, D.J., F.N. Kojima, and M.F. Smith. 2004. Estrus synchronization in postpartum beef
cows. Prof. Anim. Sci. 19:109-115.
99.
Lakritz, J., A.E. Marsh, M.Cockrell, M.F. Smith, and J.W. Tyler. 2004. Characterization of
gelatinases in bronchoalveolar lavage fluid and produced by alveolar macrophages isolated from
health calves. American J. Veterinary Research 65:163-172.
100. Perry, G.A., M.F. Smith and T.W. Geary. 2004. Ability of CIDRs and melengestrol acetate to
induce estrous cycling status in postpartum. J. Animal Sci. 82:695-704.
101. Hampton, J.H., J.F. Bader, W.R. Lamberson, M.F. Smith, R.S. Youngquist and H.A. Garverick.
2004. Gonadotropin requirements for dominant follicle selection in GnRH agonist-treated dairy
cows. J. of Reproduction. 127:695-703.
102. Stegner, J.E., F.N. Kojima, M.R. Ellersieck, M.C. Lucy, M.F. Smith and D.J. Patterson. 2004. A
comparison of progestin based protocols to synchronize estrus in postpartum beef cows. J. Anim.
Sci. 82:1016-1021.
103. Stegner, J.E., J.F. Bader, F.N. Kojima, M.R. Ellersieck, M.F. Smith and D.J. Patterson. 2004.
Fixed-time artificial insemination of postpartum beef cows at 72 or 80 hours after treatment with
the MGA® Select protocol. Theriogenology. 61:1299-1305.
11
104. Wood-Follis, S.L., F.N. Kojima, M.C. Lucy, M.F. Smith and D.J. Patterson. 2004. Estrus
synchronization in beef heifers with progestin – based protocols. I. Differences in response
based on pubertal status at the initiation of treatment. Theriogenology. 62:1518-1528.
105. Hampton, J.H., M. Manikkam, D.B. Lubahn, M.F. Smith and H.A. Garverick. 2004. Androgen
Receptor mRNA Expression in the Bovine Ovary. Domes. Anim. Endo 27:81-88.
106. Perry, G.A. and M.F. Smith. 2004. A simulation exercise to teach principles of bovine
reproductive management. J. Anim. Sci. 82:1543-1549.
107. Stegner, J.E., F.N. Kojima, J.F. Bader, M.C. Lucy, M.R. Ellersieck, M.F. Smith and D.J.
Patterson. 2004. Follicular dynamics and steroid profiles in cows during and after treatment with
progestin-based protocols for synchronization of estrus. J. Anim. Sci. 82:1022-1028.
108. J. Mao , M. F. Smith , E. B. Rucker , G. M. Wu , T. C. McCauley , T. C. Cantley , R. S. Prather,
B. A. Didion and B. N. Day . 2004. Effect of Epidermal Growth Factor and insulin-like growth
factor I on Porcine prenatral follicular growth, antrum formation and stimulation of granulose cell
proliferation and suppression of apoptosis in vitro. J. Anim. Sci. 82:1967-1975.
109. Smith, M.F., C.G. Gutierrez, W.A. Ricke, D.G. Armstrong and R. Webb. 2005 Production of
Matrix Metalloproteinases by Cultured Bovine Theca and Granulosa Cells. Reproduction.
129:75-87.
110. Bader, J.F., F.N. Kojima, D.J. Schafer, J.E. Stegner, M.R. Ellersieck, M.F. Smith, and D.J.
Patterson. 2005. A comparison of progestin-based protocols to synchronize ovulation and
facilitate fixed-time artificial insemination in postpartum beef cows. J. Anim. Sci. 83:136-143.
111. Bader, J.F., F.N. Kojima, D.J. Schafer, J.E. Stegner, M.R. Ellersieck, M.F. Smith and D.J.
Patterson. 2005. A comparison of progestin-based protocols to synchronize ovulation and
facilitate fixed-time artificial insemination in postpartum beef cows. J. Anim. Sci. 83:136-143.
112. Perry, G.A., M.F. Smith, M.C. Lucy, J.A Green, T.E. Parks, M.D. McNeil, A.J. Roberts and
T.W. Geary. 2005. Relationship between follicle size at insemination and pregnancy success.
Proc. Nat. Acad. Sci. 102:5268-5273.
113. Perry, G.A., W.V. Welshons, R.C. Bott and M.F. Smith. 2005. Basis of melengestrol acetate
action as a progestin. Domes. Anim Endo 28:147-161.
114. Lamberson W.R. and M.F. Smith. 2005. Encouraging science beyond the curriculum. J. Anim
Sci. 83:1972-1975.
115. Mao, J., G.Wu, R. S Prather, M.F. Smith, T.Cantley, A. Rieke, B.A. Didion, B.N. Day. 2005.
Effect of methyl-β-cyclodextrin treatment of pig spermatozoa on in vitro fertilization and embryo
development in the absence or presence of caffeine. Therio 64:1913-1927.
116. Curry T.E. and M.F. Smith. 2006. Impact of extracellular matrix remodeling on ovulation and the
foliculo-luteal transition. Seminars in Reproductive medicine 24:228-241.
117. Perry, G.A., M.F. Smith, A.J. Roberts, M.D. MacNeil, and T.W. Geary. 2007. Relationship
between size of ovulatory follicle and pregnancy success in beef heifers. J. Anim. Sci 85:684689.
12
118. Schafer, D.J., J.F. Bader, J.P. Meyer, J.K. Haden, M.R. Ellersieck, M.C. Lucy, M.F. Smith, and
D.J. Patterson. 2007. Comparison of progestin-based protocols to synchronize estrus and
ovulation before fixed-time artificial insemination in postpartum beef cows. J. Anim Sci
85:1940-1945.
119. Busch, D.C., D. J. Wilson, D. J. Schafer, N. R. Leitman, J. K. Haden, M. R. Ellersieck, M. F.
Smith, and D. J. Patterson. 2007. Comparison of progestin-based estrus synchronization
protocols before fixed-time artificial insemination on pregnancy rate in beef heifers. J Anim Sci
85: 1933-1939.
120. Atkins, J.A., D. C. Busch, J. F. Bader, D. H. Keisler, D. J. Patterson, M. C. Lucy, and M. F.
Smith. 2008. Gonadotropin-releasing hormone-induced ovulation and luteinizing hormone
release in beef heifers: Effect of day of the cycle. J Anim Sci 86: 83-93.
121. Busch, D.C., J. A. Atkins, J. F. Bader, D. J. Schafer, D. J. Patterson, T. W. Geary, and M. F.
Smith. 2008. Effect of ovulatory follicle size and expression of estrus on progesterone secretion
in beef cows. J Anim Sci 86:553-563.
122. Leitman, N.R., D.C. Busch, J.F. Bader, D.A. Mallory, D.J. Wilson, M.C. Lucy, M.R. Ellersieck,
M.F. Smith, and D.J. Patterson. 2008. Comparison of protocols to synchronize estrus and
ovulation in estrous-cycling and prepubertal beef heifers. J. Anim Sci 86:1808-1818.
123. Busch, D.C., D.J. Schafer, D.J. Wilson, D.A. Mallory, N.R. Leitman, J.K. Haden, M.R.
Ellersieck, M.F. Smith and D.J. Patterson. 2008. Timing of artificial insemination in postpartum
beef cows following administration of the CO-Synch + controlled internal drug-release protocol.
J. Anim Sci 86:1519-1525
124. Leitman, N.R., D.C. Busch, D.A. Mallory, D.J. Wilson, M.R. Ellersieck, M.F. Smith, and D.J.
Patterson. 2009. Comparison of long-term CIDR-based protocols to synchronize estrus in beef
heifers. Anim Repro Sci 114:345-355.
125. Leitman, N.R., D.C. Busch, D.J. Wilson, D.A. Mallory, M.R. Ellersieck, M.F. Smith, and D.J.
Patterson. 2009. Comparison of controlled internal drug release insert-based protocols to
synchronize estrus in prepubertal and estrous cycling beef heifers. J. Anim Sci. 87:3976-3982.
126. Garverick, H.A., J.L. Juengel, P. Smith, D.A. Heath, M.N. Burkhart, G.A. Perry, M.F. Smith,
and K.P. McNatty. 2009. Development of the ovary and ontogeny of mRNA and protein for
P450 aromatase (arom) and estrogen receptors (ER) alpha and Beta during early fetal life in
cattle. Anim. Reprod. Sci 117:24-33.
127. Burkhart, M.N., J.L. Juengel, P.R. Smith, D.A. Heath, G.A. Perry, M.F. Smith and H.A.
Garverick. 2010. Morphological development characterization of aromatase and estrogen
receptors alpha and beta in fetal ovaries of cattle from days 110 to 250. Anim. Reprod. Sci.
117:43-54.
128. Mallory, D.A., J. Wilson, D.C. Busch, M.R. Ellersieck, M.F. Smith, and D.J. Patterson. 2010.
Comparison of long-term progestin-based estrus synchronization protocols in beef heifers. J
Anim Sci 88:3568-3578.
129. Atkins, J.A., M.F. Smith, K.J. Wells and T.W. Geary. 2010. Factors affecting preovulatory
follicle diameter and ovulation rate after gonadotropin-releasing hormone in postpartum beef
cows. Part I: Cycling Cows. J Anim Sci 88:2300-2310.
13
130. Atkins, J.A., M.F. Smith, K.J. Wells and T.W. Geary. 2010. Factors affecting preovulatory
follicle diameter and ovulation rate after gonadotropin-releasing hormone in postpartum beef
cows. Part II: Anestrous Cow. J Anim Sci 88:2311-2320
131. D.J. Wilson, D.A. Mallory, D.C. Busch, N.R. Leitman, J.K. Haden, D.J. Schafer, M.R.
Ellersieck, M.F. Smith and D.J. Patterson. 2010. Comparison of short-term progestin-based
protocols to synchronize estrus and ovulation in postpartum beef cows. J Anim Sci 88:20452054.
132. J. Franken, J. Parcell, D. Patterson, M.Smith, and S. Poock. 2010. Cow-calf producer interest in
retained ownership. J of Agribusiness 28(1)49-59.
133. Mallory, D.A., D.J. Wilson, D.C. Busch, M.R. Ellersieck, M.F.Smith, and D.J. Patterson.
2010. Comparison of long-term progestin-based estrus synchronization protocols in beef
heifers. J. Anim. Sci. 88:3568-3578.
134. Mallory, D.A., J. M. Nash, M.R. Ellersieck, M.F. Smith, and D.J. Patterson. 2011. Comparison of
long-term progestin-based protocols to synchronize estrus before fixed-time artificial
insemination in beef heifers. J. Anim. Sci. 89:1358-1365.
135. Nash, J.M., D. A. Mallory, M.R. Ellersieck, S.E. Poock, M.F. Smith, and D. J. Patterson.
2012. Comparison of long- verses short-term CIDR-based protocols to synchronize estrus
prior to fixed-time AI in postpartum beef cows. Anim. Reprod. Sci. 132: 11-16.
136. Pohler, K.G., T.W. Geary, J. A. Atkins, G. A. Perry, E. M. Jinks, and M.F. Smith, 2012,
Follicular Determinants of Pregnancy Establishment and Maintenance, Cell and Tissue
Research 349: 649-664.
137. Atkins, J.A., M. F. Smith, M. D. MacNeil, E. M. Jinks, F. M. Abreu, L. J. Alexander, and
T. W. Geary, 2013, Pregnancy establishment and maintenance in cattle, J. Anima. Sci. (In
press).
138. Jinks, E. M., M. F. Smith, J. A. Atkins, K. G. Pohler, G. A. Perry, M. D. MacNeil, A. J.
Roberts, R. C. Waterman and T. W. Geary, 2013, Preovulatory estradiol and the
establishment and maintenance of pregnancy in suckled beef cows, J. Anim. Sci. (In
press).
139. Geary, T.W., M. F. Smith, M. D. MacNeil, M. L. Day, G. A. Bridges, G. A. Perry, F. M. Abreu,
J. A. Atkins, K. G. Pohler, E. M. Jinks, and C. A. Madsen. 2013. Influence of Follicular
Characteristics at Ovulation on Early Embryo Survival. J. Anim. Sci (In press).
Book Chapter:
1.
Garverick, H.A. and M.F. Smith. 1993. Female Reproductive Physiology and Endocrinology of
Cattle. In: Braun and Youngquist (Ed.) Clinics of North America. W.B. Saunders Co.,
Philadelphia. pp. 223-247.
2.
Patterson, D.J., S.L. Wood, F.N. Kojima, and M.F. Smith. 2002. Control of the bovine estrous
cycle with melengestrol acetate In: Factors affecting calf crop: Biotechnology of Reproduction.
CRC Press LLK, Boca Raton, FL. pp.57-86.
14
3.
Bolden-Tiller, O.U., and M.F. Smith. 2004. Hormones: Steroid Encyclopedia of Animal
Science. Marcel Dekker, Inc. pp. 523-527.
4.
Prather, R.S. and M.F. Smith. 2006. Reproductive Biotechnologies. In: Biotechnology Patent
Law Technology, R. Brungs & M. Postiglione, eds. ITEST Faith Sciences Press, St. Louis, MO.
pp 1-13.
5.
Patterson D.J. and M.F. Smith. 2007. Progestogen-based estrus synchronization for beef
replacement heifers and cows. In: R.S. Youngquist and W.R. Threlfall (Ed.) Large Animal
Theriogenology. Saunders Elsevier, St. Louis, MO pp 278-286.