Michael J. O’Connor, MD
Department of Neurosurgery
Jefferson University Hospital
Phone: (215) 955-0951
Fax: (215) 955-0957
Address:
1015 Chestnut Street
Suite 1400
Philadelphia, PA 19107
Education
9/1959 to 5/1963
Bachelor Science
Electrical Engineer: University of Pennsylvania
The Moore School of Electrical Engineering
Philadelphia, PA
9/1963 to 5/1967
Medical Doctorate: University of Pennsylvania School of Medicine
3400 Spruce Street, Philadelphia, PA 19104
Postgraduate Training
7/1/67-6/30/68
Intern in General Surgery, Hospital of the University of Pennsylvania, 3400
Spruce Street, Philadelphia, PA 19104
7/1/68-6/30/70
Neurosurgical Resident, Hospital of the University of Pennsylvania
7/1/72-6/30/74
Neurosurgical Resident, Hospital of the University of Pennsylvania
Military Service
7/1/70-6/30/72
Lieutenant Commander - USPHS-NIH, NINCHS Branch of EEG and Clinical
Neurophysiology
Faculty Appointments
1/97-Present
Professor of Neurosurgery
Thomas Jefferson University Hospital
111 S. 11th Street, Philadelphia, PA 19107
9/83-12/96
Associate Professor of Neurosurgery
University of Pennsylvania Medical Center
3400 Spruce Street, Philadelphia, PA 19104
7/74-9/83
Assistant Professor, Department of Neurosurgery
University of Pennsylvania Medical Center
3400 Spruce Street, Philadelphia, PA 19104
Hospital Appointments
1/97-Present
Attending Neurosurgeon, Thomas Jefferson University Hospital
111 S. 11th Street, Philadelphia, PA 19107
10/1998-Present
Associate Attending Neurosurgeon
Albert Einstein Medical Center,
5501 Old York Road, Philadelphia, Pennsylvania 19141
1/1977-Present
Attending Neurosurgeon
St. Agnes Medical Center
1900 S. Broad Street, Philadelphia, Pennsylvania 19145
12/74-Present
Attending Neurosurgeon
Graduate Hospital
1800 Lombard Street, Philadelphia, Pennsylvania 19146
4/97-11/00
Attending Neurosurgeon
Wills Eye Hospital
9th & Walnut Street, Philadelphia, Pennsylvania 19107
1/1975-1/1997
Attending Neurosurgeon
Pennsylvania Hospital
800 Spruce Street, Philadelphia, Pennsylvania 19107
1/1977-1/1997
Attending Neurosurgeon
Presbyterian-University of Pennsylvania Medical Center
39th & Market Street, Philadelphia, Pennsylvania 19104
Administrative Appointments
9/2000-4/2002
Resident Program Director
Department of Neurosurgery
Thomas Jefferson University Hospital
111 S. 11th Street – Suite 8330, Philadelphia Pennsylvania 19107
7/1981-1/1997
Chief, Division of Neurosurgery
Graduate Hospital
1800 Lombard Street, Philadelphia, Pennsylvania 19146
1/1982 – 12/1982
President, Center City Chapter, Philadelphia County Medical Society
Specialty Certification
9/1979, American Board of Neurological Surgery
Licensure
Pennsylvania, # MDO30141L
Awards & Membership in Honorary Societies
Eta Kappa Nu
Sigma XI
11/1993
Epilepsy Foundation of Southeastern Pennsylvania Award
1993
Founders Award, Epilepsy Foundation of Southeastern Pennsylvania
Membership in Professional & Scientific Societies
American Medical Association
American Association of Neurologic Surgery
Congress of Neurologic Surgeons
American Epilepsy Society
Society of Neurologic Surgeons
Philadelphia County Medical Society
Philadelphia Academy of Surgery
College of Physicians
Philadelphia Neurological Society
Pennsylvania Medical Society
Fellowships
American College of Surgeons - 12/1992
Grant Involvement
Molecular and Cellular Biology of HIV Encephalopathy, Project 1: HIV infection
of human neural cells, NS27405-12, 09/01/01-08/31/02. Francisco GonzalezScarano, MD, Principal Investigator.
NIH, #1231352685A1. Genetic susceptibility of human epilepsy, 12/01/9811/30/03, Russell J. Buono, PhD, Principal Investigator.Current:
Cellular Basis of Epilepsy. 7/01/97-6/30/00; Leona Masukawa, PhD, Principal
Investigator.
Multicenter Study of Epilepsy Surgery, 1 RO1 NS32375-01A12. 04/04/9601/31/97; NS32375-02, 04/04/96- 01/31/2001. Susan Spencer, MD, Principal
Investigator.
Local Cerebral Glucose Metabolism in Man, NIH NS14867. 04/01/92-03/01/97.
Martin Revich, MD, Principal Investigator. Sub project to above grant: STA-MCA
Anastomosis: Effects on cerebral function, blood flow and metabolism, NS1486701. Michael J. O'Connor, MD, Principal Investigator.
Cellular Mechanisms of Epilepsy, NIH NS23077. 07/01/94-06/30/95 $130,245.
Leona Masukawa, PhD, Principal Investigator.
Subcortical Metabolic Alterations in Epilepsy, NIH 1 RO1 NS26178, 04/01/8903/31/93. Michael Sperling, MD, Principal Investigator.
Submitted Grants
Functional MRI Studies of Refractory Epilepsy. Pending. 04/01/97-03/31/02;
John Detre, MD, Principal Investigator.
Public Health Service. Submitted. Genetic susceptibility of human epilepsy,
07/01/99-06/30/04, Russell J. Buono, PhD, Principal Investigator.
The Charles A. Dana Foundation. Submitted. Identifying aberrant
neurocognitive circuits caused by secondary epileptogenesis. Joseph I. Tracy,
Ph.D, Principal Investigator.
Bibliography
Jobsis F, Legallis V, O'Connor MJ: A regulated differential fluorometer for the
assay of the oxidative metabolism in intact tissue. I.E.E.E., Trans on Bio-Med.
13:93-99,1966.
Jobsis F, O'Connor MJ: Calcium release and reabsorption in the sartorius muscle
of the toad. Biochem and Biopsy, Res. Comm. 25:246-252,1966.
O'Connor MJ, Rosenthal M, Jobsis FF: Long term EEG changes during direct
cortical stimulation. Electroenceph and Clinical Neurophysiology 27:280288,1968.
Jobsis FF, O'Connor MJ, Vitale A, Vreman J: Intracellular redox changes in
functioning cerebral cortex I. Metabolic effects of epileptiform activity. J
Neurophysiology 34:750-762,1971.
O'Connor MJ, Herman CJ, Rosenthal M, Jobsis FF: Intracellular redox changes
preceding onset of epileptiform activity in the intact cat hippocampus. J.
Neurophysiology. 35:471-483, 1972.
O'Connor MJ, Lewis DV, Herman CJ: Effects of potassium on oxidative
metabolism and seizures. Electroenceph. Clinc. Neurophysiol. 35:205-208,
1973.
O'Connor MJ, Lewis DV: Recurrent seizures induced by potassium in the
penicillin treated hippocampus. Electroenceph. Clinc. Neurophysiol. 36:337345. 1974.
Lewis DV, O'Connor MJ, Schuette W: Oxidative metabolism during recurrent
seizures in the penicillin treated hippocampus. Electroenceph.Clinc.
Neurophysiol. 36:347-356, 1974.
Schuette W, Whitehouse W, Lewis DV, O'Connor MJ, VanBuren JM: A television
fluorometer for monitoring oxidative metabolism in intact tissue. J. of Assoc. for
Advancement of Medical Instrumentation. 8:331-333, 1974.
O'Connor MJ: Comparison of two methods of post-operative pulmonary care.
Surg.Gyn.Obs. 144:615-617, 1975.
Welsh FA, O'Connor MJ, Rieder W, et al: Regional changes in metabolism in
hypoxia-ischemia. Adv.Exp.Med.Biol. 78: 275-286, 1976.
Welsh FA, O'Connor MJ, Langfitt TW: Regions of cerebral ischemia located by
pyridine nucleotide of fluorescence. Science 198: 951-953, 1977.
Lin SR, O'Connor MJ: The effect of Dextran on cerebral function and blood flow
after cardiac arrest. Ibid., 6.16-6.18, 1977.
Obrist WD, Langfitt TW, TerWeeme CA, O'Connor MJ, Gennarelli T, Zimmerman
R: Non-invasive, long term, serial studies of rCBF in acute head injury. Ibid 9.29.3, 1977.
Langfitt TW, Obrist W, Gennarelli T, O'Connor MJ, TerWeeme C: Correlation of
CBF with outcome in head injured patients. Ann. Surg. 186: 411-414, 1977.
Marcy VR, Komarnicky L, O'Connor MJ, Welsh F, Graham D: Abnormalities
associated with reversible and irreversible brain damage following a time varied
oligemic insult. Acta Neurol. Scand. Suppl. (Denmark) 64:124-125, 1977.
Welsh FA, O'Connor MJ: Patterns of microcirculatory failure during incomplete
cerebral ischemia. Adv. Neurol. 20:133-139, 1978.
Welsh FA, O'Connor MJ, Marcy VR: Effect of oligemia on regional metabolite
levels in cat brain. J. of Neurochem. 31:311-319, 1978.
Lin SR, O'Connor MJ, Fischer HE, King A: The effect of combined Dextran and
streptokinase on cerebral function and blood flow after the cardiac arrest. An
experimental study on the dog. Invest. Radiol. 13: 490-498, 1978.
Welsh FA, Johns R, Spatacco A, Scheartz R, O'Connor MJ, Ginsburg M:
Selective energy failure in cerebral white matter. Acta.Neuro. Scan. 60: Supp.
72, 362-363, 1979.
Laurent J, Lawner P, O'Connor MJ, Hungerbuhler J, Obrist W, Goldberg H,
Gordon J: Correction of intracerebral steal by extracranial/intracranial
anastomosis. Acta.Neuro.Scan. 60: Supp. 72, 496-497, 1979.
O'Connor MJ: Proposed control of seizures by neuronal electrogenic sodium
pump activity. Acta.Neuro.Scan. 60: 72, 556-557, 1979.
Parry G, Harper CG, Wright DM, O'Connor MJ: Cryptococcal granuloma
presenting as an intracranial mass. Surgical Neurol. J. 11: 425-429, 1979.
Lin SR, O'Connor MJ, King A, Harnish P, Fischer HW: Effect of dextran on
cerebral function and blood flow after cardiac arrest. An experimental study on
the dog. Stroke. 10:13-20, 1979.
Barlow CH, Harden WR, Harkin AH, Simpson MB, Haselgrove JC, Chance B,
O'Connor MJ, Austin G: Fluorescence mapping of mitochondria redox changes in
heart and brain. Crit. Care Med. 7:402-406, 1979.
Hungerbuhler JP, Younkin D, Reivich M, Obrist WD, O'Connor MJ, Goldberg H,
Gordon J, Gur R, Hurtig H, Epstein D, Amarnek W: The effect of STA-MCA
anastomosis on rCBF, neurologic and neuropsychologic function in patients with
completed strokes. Excerpta. pp. 73-75, 1981.
Welsh A, O'Connor MJ, Marcy VR, Spatacco AJ, Johns RL: Factors limiting
regeneration of ATP following temporary ischemia in cat brain. Stroke. 13:2:
234-242. 1982.
Laurent JO, Lawner PM, O'Connor MJ: Reversal of intracerebral steal by STAMCA anastomosis. J. Neurosurg. 57: 629-632, 1982.
O'Connor MJ: Cerebral metabolism in the acute severely head injured patient:
Primary metabolic depression vs. ischemic hypoxia. Clinc. Neurosurg. 29:146161, 1982.
Gur RC, Sussman NM, Gur RE, O'Connor MJ: Emission tomography in two
cases of childhood epileptic encephalopathy (Lennos-Gastaut Syndrome). J.
Neurology. 32:1191-1194, 1982.
Sussman NM, Gur RC, Gur RE, O'Connor MJ: Mutism as a consequence of
callosotomy. J. Neurosurg. 59:514-519, 1983.
Gur RE, Gur RC, Sussman NM, O'Connor MJ, Vey MM: Hemispheric control of
the right hand. The effect of callosotomy in the left hander. Neurology
34(7):904-908, 1984
Younkin D, Hungerbuhler JP, O'Connor MJ, Goldberg H, Burke A, Kushner M,
Hurtig HI, Obrist W, Gordon J, Gur R, Reivich M.: Superficial temporal-middle
cerebral artery anastomosis: Effects on vascular, neurologic, and
neuropsychological functions. Neurology. 35:462-468, 1985.
Sussman NM, Scanlon M, Garfinkle W, Callanan M, O'Connor MJ, Harner RN:
Magnetic resonance imaging after corpus callosotomy. Neurology 37:(2) 350354, 1987.
Saykin AJ, Gur RC, Sussman NM, O'Connor MJ, Gur RE: Memory deficits
before and after temporal lobectomy: Effects of laterality and age of onset. Brain
and Cognition, 9:191-200, 1989.
Sperling MR, O'Connor MJ: Comparison of depth and subdural electrodes in
recording temporal lobe seizures. Neurology. 39:1497-1504, 1989.
Sperling MR, O'Connor MJ, Saykin A: The New Graduate Hospital Epilepsy
Program; Initial Results. Neurology 38 (Supp. 1). 279-280, 1989.
Raps EC, Gutmann DH, Bronson JR, O'Connor MJ, Hurtig HI: Symptomatic
hydrocephalus and reversible spinal cord compression in listeria monocytogenes
meningitis. J. Neurosurg. 71:620-622, 1989.
Bridgeman PA, Malamut BL, Sperling MR, Saykin AJ, O'Connor MJ: Memory
during subclinical hippocampal seizures. Neurology 39:853-856, 1989.
Sperling MR, O'Connor MJ: Auras and subclinical seizures: Characteristics and
prognostic significance. Annals of Neurology, 28:320-328, 1990.
Stafiniak P, Saykin AJ, Sperling MR, Kester DB, Robinson LJ, O'Connor MJ, Gur
RC: Acute naming deficits following dominant temporal lobectomy: Prediction
by age at first risk for seizures. Neurology 40:1509-1512, 1990.
Saykin AJ, Sperling MR, Robinson LJ, O'Connor MJ, et al: Neuropsychological
prediction of seizure outcome in anterior lobectomy candidates. J. Clinc Exp
Neuropsychol. 12:71, 1990.
Sperling MR, Gur RC, Alavi A, Gur RE, Resnick S, O'Connor MJ, Reivich M:
Subcortical metabolic alterations in partial epilepsy. Epilepsia 31:145-155, 1990.
Masukawa LM, Higashima M, Hart GJ, Spencer DD, O'Connor MJ: NMDA
receptor activation during epileptiform responses in the dentate gyrus of epileptic
patients. Brain Research 562:176-180, 1991.
Kester DB, Saykin AJ, Sperling MR, O'Connor MJ, Robinson LJ, Gur RC: Acute
effect of anterior temporal lobectomy of musical processing. Neuropsychologia
29:703-708, 1991.
Morrell MJ, Phillips CA, O'Connor MJ, Sperling MR: Speech during partial
seizures: Intracranial EEG correlates. Epilepsia 32:886-889, 1991.
Barry E, Sussman NM, O'Connor MJ, Harner RN: Presurgical
electroencephalographic patterns and outcome from anterior temporal
lobectomy. Arch of Neurology 49(1)21-27, 1992.
Brooks ML, O'Connor MJ, Sperling MR, Mayer DP: MRI in localization of EEG
depth electrodes for seizure monitoring. Epilepsia 33:888-891, 1992.
Sperling MR, O'Connor MJ, Saykin AJ, Phillips CA, Morrell MJ, Bridgeman PA,
French JA, Gonatas N: A non-invasive protocol for anterior temporal lobectomy.
Neurology 42:416-422, 1992.
Masukawa LM, Uruno K, Sperling M, O'Connor MJ, Burdette LJ: The functional
relationship between antidromically evoked field responses of the dentate gyrus
and mossy fiber reorganization in temporal lobe epileptic patients. Brain
Research 579, 119-127, 1992.
Epstein MA, Sperling MR, O'Connor MJ: Cardiac rhythm during temporal lobe
seizures. Neurology 42:50-53, 1992.
O'Rourke DM, Saykin AJ, Gilhool JJ, Harley R, O'Connor MJ, Sperling MR:
Unilateral hemispheric memory and hippocampal neuronal density in temporal
lobe epilepsy. Neurosurgery 32:574-581, 1993.
Uruno K, O'Connor MJ, Masukawa LM: Alterations of inhibitory synaptic
responses in the dentate gyrus of temporal lobe epileptic patients. Hippocampus
4:583-593, 1994.
Sperling MR, Saykin AJ, Glosser G, Moran M, French JA, O'Connor MJ:
Predictors of outcome after anterior temporal lobectomy: The intracarotid
amobarbital test. Neurology 44:2325-2330, 1994.
Manno EM, Sperling MR, Ding XS, Jaggi J, Alavi A, O'Connor MJ, Reivich M.:
Predictors of outcome after anterior temporal lobectomy: Positron emission
tomography. Neurology 44:2331-2336, 1994.
Gogate N, Verma L, Zhou JM, Milward E, Rusten R, O'Connor M, Kufta C, Kim J,
Hudson L, Dubois-Dalcq M: Plasticity in the Adult Human Oligodendrocyte
Lineage. J of Neuroscience August 14(8):4571-4587, 1994.
Freese A., O'Rourke D, Judy K, O'Connor MJ: Application of 5bromodeoxyuridine to neurosurgery. J. Neuro-Onc. 20(1)81-95, 1994.
Katsetos CD, Krishna L, Giannakopoulos G, Sedor D, Yang WC, Noh JM, Allen
LW, Alemo-Hammad S, Northrup B, O'Connor MJ: Lobar pilocytic astrocytomas
of the cerebral hemispheres: diagnosis, nosology and pathobiology. Clin Neuro
Path 13:295-305, 1994.
Uruno K, O'Connor MJ, Masukawa LM: Alterations of inhibitory synaptic circuitry
in the dentate gyrus of temporal lobe epileptic patients. Hippocampus 4(5):58393, 1994.
Subramaniam S, O'Connor MJ, Masukawa L, McGonigle P: Polyamine effects
on the NMDA receptor in human brain. Expt. Neurol. 130(2):323-330, 1994.
Matsuo ES, Shin RW, Billingsley ML, deVoorde AV, O'Connor M, Trojanowski
JQ, Lee VM: Biopsy-derived adult human brain tau is phosphorylated at many of
the same sites as Alzheimer's disease paired helical filament tau. Neuron, Vol.
13, 989-1002, October 1994.
Burgerman RS, Sperling MR, French JA, Saykin AJ, O'Connor MJ,: Comparison
of mesial vs. neocortical onset of temporal lobe seizures: Neurodiagnostic
findings and surgical outcome. Epilepsia 36:662-670, 1995.
Tatum WO, Sperling MR, O'Connor MJ, Jacobstein JG: Interictal SPECT in the
Presurgical Evaluation of Intractable Partial Epilepsy. J of Neuroimaging 5:142144, 1995.
Laskowitz DT, Sperling MR, French JA, O'Connor MJ: The syndrome of frontal
lobe epilepsy: Characteristics and surgical management. Neurology 45:780-787,
1995.
Sperling MR, Alavi A, Reivich M, French JA, O'Connor MJ: False localization of
temporal lobe epilepsy with FDG positron emission tomography. Epilepsia
36:722-727, 1995.
Sperling MR, Saykin AJ, Roberts D, French JA, O'Connor MJ: Occupational
outcome after temporal lobectomy for refractory epilepsy. Neurology 45:970977, 1995.
Masukawa LM, O'Connor WM, Lynott J, Burdette LJ, Uruno K, McGonigle P,
O'Connor MJ: Longitudinal variation in cell density and mossy fiber
reorganization in the dentate gyrus from temporal lobe epileptic patients. Brain
Res. 678(1-2):65-75, 1995.
Wilt SG, Milward E, Zhou JM, Nagasato K, Patton H, Rusten R, Griffin DE,
O'Connor M, Dubois-Dalcq, M: In vitro evidence for a dual role of tumor necrosis
factor alpha in human immunodeficiency virus type I encephalopathy. Annals of
Neurology 37:381-394, 1995.
Uruno K, O'Connor MJ, Masukawa LM: Effects of bicuculline and baclofen on
paired-pulse depression in the dentate gyrus of epileptic patients. Brain
Research 695(2):163-72, 1995.
Saykin AJ, Stafiniak P, Robinson LJ, Sperling MR, Gur RC, O'Connor MJ:
Language before and after temporal lobectomy: Specificity of acute changes and
relation to early risk factors. Epilepsia 36(11):1071-1077, 1995.
Glosser G, Saykin AJ, Deutsch GK, O'Connor MJ, Sperling MR: Neural
organization of material-specific memory functions in temporal lobe epilepsy
patients as assessed by the intracarotid amobarbital test. Neuropsychology
9:449-456, 1995.
Detre JA, Sirven JI, Alsop DC, O'Connor MJ, French JA: Localization of
subclinical ictal activity by functional magnetic resonance imaging: correlation
with invasive monitoring. Ann Neurol 38:618-624, 1995.
O'Connor WM, Masukawa LM, Freese A, Sperling MR, French JA, O'Connor MJ:
Hippocampal cell distribution in temporal lobe epilepsy: A comparison between
patients with and without an early risk factor. Epilepsia 37(5):440-449, 1996.
Masukawa LM, Wang H, O'Connor MJ, Uruno K: Prolonged field potentials
evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human
brain slices. Brain Research 721:132-139, 1996.
Sirven JI, Sperling MR, French JA, O'Connor MJ: The significance of simple
partial seizures in temporal lobe epilepsy. Epilepsia 37(5):450-454, 1996.
Albright AV, Strizki J, Harouse JM, Lavi E, O'Connor MJ, Gonzalez-Scarano F:
HIV-1 infection of cultured human adult oligodendrocytes. J Virology 217: 211219, 1996.
Albright AV, Lavi E, O'Connor M, Gonzalez-Scarano F: HIV-1 infection of a CD4negative primary cell type: The oligodendrocyte. Perspectives in Drug Discovery
and Design, Vol. 5, 43-50, 1996
Sperling MR, O'Connor MJ, Saykin AJ, Plummer C: Temporal lobectomy for
refractory epilepsy: Outcome five years after surgery. JAMA 276:470-475, 1996.
Masukawa LM, Wang H, O'Connor MJ, Urono K: Prolonged field potentials
evoked by 1 Hz stimulation in the dentate gyrus of temporal lobe epileptic human
brain slices. Brain Research 721:132-139, 1996.
Freese A, Stern M, Kaplitt MG, O'Connor WM, Abbey MV, O'Connor MJ, During
MJ: Prospects for gene therapy in Parkinson's disease. Movement Disorders
11(5):469-488, 1996.
Strizki JM, Albright AV, Sheng H, O'Connor M, Perrin L, Gonzalez-Scarano F:
Infection of primary human microglia and monocyte-derived macrophages with
acute HIV-1 isolates: evidence of differential tropism. J Virology 70(11):76547662, 1996.
O'Connor WM, Masukawa L, Freese A, Sperling MR, French JA, O'Connor MJ:
Hippocampal cell distributions in temporal lobe epilepsy: a comparison between
patients with and without an early risk factor. Epilepsia 37:440-449, 1996.
McCarthy RJ, O'Connor MJ, Sperling MR: The mirror focus phenomenon and
secondary epileptogenesis in human epilepsy. J of Epilepsy 10:78-85, 1997.
Sirven JI, Liporace JD, French JA, O'Connor MJ, Sperling MR: Seizures in
temporal lobe epilepsy: I. Reliability of scalp/sphenoidal ictal recording.
Neurology 48:1041-1046, 1997.
Lavi E, Strizki JM, Ulrich AM, Zhang W, Fu L, Wang Q, O'Connor MJ, Hoxie JA,
Gonzalez-Scarano F: CXCR-4 (Fusin), a co-receptor for the type 1 human
immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of
cell types including microglia and neurons. Am J Path 151:1035-1042, 1997.
O'Connor WM, Davidson B, Kaplitt MG, O'Connor MJ, Langer D, During MJ,
Freese A: Adenovirus vector mediated gene transfer into human epileptogenic
brain slices::Prospects for gene therapy in Epilepsy, Experimental Neurology
148:167-178, 1997.
King JT, Sperling MR, Justice AC, O'Connor MJ: A cost-effectiveness analysis of
anterior temporal lobectomy for intractable temporal lobe epilepsy. J
Neurosurgery 87:20-28, 1997.
Freese A, Kaplitt MG, O'Connor WM, Abbey M, Langer D, Leone P, O'Connor
MJ, During MJ: Direct gene transfer into human epileptogenic hippocampal
tissue with an adeno-associated virus vector: Implications for a gene therapy
approach to epilepsy. Epilepsia 38(7):759-766, 1997.
Sirven JI, Malamut BL, Liporace JD, O'Connor MJ, Sperling MR: Outcome after
temporal lobectomy in bilateral temporal lobe epilepsy. Ann Neurol 42:873-878,
1997.
Freese A, Davidson B, O'Connor WM, During MJ, Kaplitt M, O'Connor MJ:
Preferential expression of the LacZ trans gene in dividing glial cells after
adenovirus transfer to mixed neuronal-glial cultures. Exp Neurol In Press, 1997.
Albright AV, Lavi E, Black JB, Goldberg S, O'Connor MJ, Gonzalez-Scarano F:
The effect of human herpes virus 6 (HHV-6) on cultured human neural cells:
oligodendrocytes and microglia. J. Neurovirol 4(5):486-494, October 1998.
Albright AV, Shieh JTC, Itoh T, Lee B, Pleasure D, O'Connor MJ, Doms RW,
Gonzalez-Scarano F: Microglia express CCR5, CXCR4, and CCR3, but of
these, CCR5 is the principal coreceptor for human immunodeficiency virus type 1
dementia isolates . J of Virology 73(1):205-213, January 1999.
Sperling MR, Feldman H, Kinman J, Liporace JD, O'Connor MJ: Seizure control
and mortality in epilepsy. Annals of Neurol 46(1):45-50, July 1999.
Veznedaroglu E, Van Bockstaele EJ, O'Connor MJ: Extravascular collegen in
the human epileptic brain: A potential substrate for aberant cell migration in
human temporal lobe epilepsy. Submitted Nature Neuroscience 1998.
Swanson TH, Sperling MR, O'Connor MJ. Strong paired pulse depression of
dentate granule cells in slices from patients with temporal lobe epilepsy. J of
Neural Transmission (Budapest) 105(6-7):613-625, 1998.
Sperling MR, Feldman H, Kinman J, Liporace JD, O'Connor, MJ: Seizure control
and mortality in epilepsy. Ann Neurol 46:45-50, 1999.
Carran MA, Kohler CG, O'Connor MJ, Cloud B, Sperling MR: Marital status after
epilepsy surgery. Epilepsia 40:1755-1760, 1999.
Dlugos DJ, Jaggi J, O'Connor WM, Ding X, Reivich M, O'Connor MJ, Sperling
MR: Hippocampal cell density and subcortical metabolism in temporal lobe
epilepsy. Epilepsia 40(4) 408-413, 1999.
Kohler C, Norstrand JA, Baltuch G, O'Connor MJ, Gur RE, French JA, Sperling
MR: Depression in temporal lobe epilepsy before epilepsy surgery. Epilepsia
40(3):336-340, 1999.
Masukawa LM, Burdette LJ, McGonigle P, Wang H, O'Connor W, Sperling MR,
O'Connor MJ, Uruno K. Physiological and anatomical correlates of the human
dentate gyrus: consequences or causes of epilepsy. [Review][95 refs] Advances
in Neurol 79:781-794, 1999.
Buono RJ, Ferraro TN, O'Connor MJ, Sperling MR, Abbey M, Finanger E, Lohoff
F, Mulholland N, Berrettini WH: Lack of association between temporal lobe
epilepsy and a novel polymorphism in the alpha 2 subunit gene (ATP1A2) of the
sodium potassium transporting ATPase. American J Med Genetics
(Neuropsychiatric Genetics) 96:79-83, 2000.
Sirven JL, Malamut BL, O'Connor MJ, Sperling MR: Temporal lobectomy
outcome in older versus younger adults. Neurol 54(11):2166-2170, 2000.
Albright AV, Shieh JTC, O'Connor MJ, Gonzalez-Scarano F: Characterization of
cultured microglia that can be infected by HIV-1. J of Neurovirology 6, S1:S5360, 2000
Lippman C, Kaplitt MG, During MJ, Abbey MV, O'Connor WM, O'Connor MJ,
Freese A: A neuroprotective role of human heat shock protein-72 following gene
transfer. Submitted 2000.
Glosser G, Zwil AS, Glosser DS, O'Connor MJ, Sperling MR: Psychiatric aspects
of temporal lobe epilepsy before and after anterior temporal lobectomy. J of
Neurol, Neurosurg & Psychiatry 68(1):53-58, January 2000.
Kohler CG, Moberg PJ, Gur RE, O'Connor MJ, Sperling MR, Doty RL: Olfactory
dysfunction in schizophrenia and temporal lobe epilepsy. Neuropsychiatry,
Neuropsychology and Behavioral Neurology (in press)
Sperling MR, Harris A, Nei M, Liporace J, O'Connor MJ: Mortality due to
refractory epilepsy. (submitted)
Kohler CG, Carran MA, Bilker W, O'Connor MJ, Sperling MR: Association of fear
auras with mood and anxiety disorders following temporal lobectomy. Epilepsia
42:674-681, 2001.
Buono RJ, Ferraro TN, O'Connor MJ, Sperling MR, Ryan SG, Scattergood T,
Mulholland N, Gilmore J, Lohoff FW, Berrettini WH: Lack of association between
an interleukin 1Beta (IL-1B) gene variation and refractory temporal lobe epilepsy.
Epilepsia 42:782-784, 2001.
Ma X, Liporace JD, O'Connor MJ, Sperling MR: Neurosurgical treatment of
prolonged medically intractable status epilepticus. Epilepsy Research 46:33-38,
2001.
Spencer SS, Schramm J, Wyler A, O'Connor MJ, Orbach D, Krauss G, Sperling
M, Devinsky O, Elger C, Lesser RF, Mulligan L, Westerveld M: Multiple subpial
transection for intractable partial epilepsy: an international meta analysis.
Epilepsia 43:141-146, 2002.
Ryan LM, Malamut BL, O'Connor MJ, Sperling MR: Predictors of depression
following anterior temporal lobectomy. (submitted Epilepsia)
O'Connor MJ, Jobsis F: A triphasic EEG response with parallels to learning and
memory. Fed. Proc. 27:388, 1968.
O'Connor MJ, Lin SR, King A, Fischer HW: Evaluation of therapeutic
mechanisms of plasma expander and fibrinolytic agent following cardiac arrest.
An experimental study on the dog. Res. 17:166, 1979.
Barlow C, Chance B, O'Connor MJ, Kanamuller H, Austin G, Jutzy R:
Intraoperative monitoring of localized hypoxia in brain cortex. Fed Pro, Vol 38,
Part II, page 1044, 1979
Sussman NM, Gur RC, Gur RE, O'Connor MJ, Harner R: A case of mutism
following corpus callosotomy. Abstract Neurology, 1981.
Gur RE, Sussman NM, O'Connor MJ, Vey MM, Gur RC: The effect of corpus
callosotomy on writing in a left hander with left hemisphere language. Abstract
Neurology, April 1982.
Meleis H, Sussman NM, Harner R, Takashima S, O'Connor MJ, Gur RE, Gur RC:
Measurement of hemispheric in phase electro-encephalographic interactions
before and after callosotomy. Abstract Neurology, April 1982.
Sperling MR, Zimmerman, R, O'Connor, MJ, Gonatas, N: MRI in refractory
partial epilepsy. Epilepsia 28:627, 1987.
Sperling MR, Gur R, Alavi J, Gur R, O'Connor MJ, Reivich M: PET studies of
subcortical metabolic activity in epilepsy. Epilepsia 28:621, 1987.
Phillips CA, Morrell MJ, O'Connor MJ, Sperling MR: Ictal speech:
Electrophysiologic correlates. Epilepsia 29:668, 1988.
Saykin AJ, Sperling MR, Kester DB, Reinecke LJ, O'Connor MJ, Gur RC: Acute
neuropsychological changes following temporal resection; laterality effects for
memory, language and music. Epilepsia 29:5, 669, 1988.
Sperling MR, Tougas P, Phillips CA, O'Connor MJ: The utility of depth and
subdural electrodes in recording temporal lobe seizures. Epilepsia 29:679, 1988.
Phillips C, Morrell MJ, Sperling MR, O'Connor MJ: Ictal speech,
Electrophysiologic correlates. Epilepsia 29:668, 1988.
Phillips C, Sperling MR, Morrell MJ, O'Connor MJ: Anatomical correlates of
awareness of seizures. Epilepsia 29:652, 1988.
Saykin AJ, Sperling MR, Kester DB, Reinicke L, O'Connor MJ, Gur, RC: Acute
neuropsychological changes following temporal resection; laterality effects for
memory, language and music. Epilepsia, 29: 669, 1988.
Sperling MR, O'Connor MJ: Significance of subclinical seizures recorded with
intracranial electrodes. Epilepsia 30(5)694-695, 1989.
McGonigle P, Lexow N, Dichter MA, O'Connor MJ: Abstract 15, 1989.
Reinicke LJ, Saykin AJ, Sperling MR, Roberts D, Kester DB, Gur RC, O'Connor
MJ: Neurobehavioral changes following anterior temporal lobectomy: Patient
and family perception assessed with a structural interview. Epilepsia. 30:727,
1989.
Saykin AJ, Sperling MR, Reinicke LJ, Kester DB, O'Connor MJ, Gur RC:
Neuropsychological prediction of seizure outcome in anterior temporal lobectomy
candidates, Journal of Clinical and Experimental Neuropsychology, 12:1, 1990.
Masukawa LM, Higashima M, Spencer DD, O'Connor M: Intracellular neuronal
responses in hippocampus and dentate gyrus of epilepsy patients studied in vitro
brain slices. Society for Neurosci Abst. 16:448,1990.
Tatum WO, Sperling MR, O'Connor MJ, Jacobstein JG: Interictal SPECT in the
presurgical evaluation of intractable partial epilepsy. Epilepsia 31:670. 1990.
Sperling, MR, O'Connor MJ, Morrell MJ, Phillips CA, Bridgeman PA, Tatum WO,
French JA: A non-invasive protocol for anterior temporal lobectomy. Epilepsia
31:637, 1990.
Morrell MJ, Sperling MR, O'Connor MJ: Propagation pathways in partial seizures
of mesial temporal lobe origin. Epilepsia 31:620, 1990.
Morrell MJ, Sperling MR, O'Connor MJ: The frontal lobe in the clinical expression
and surgical evaluation of partial epilepsy. Epilepsia 31:637, 1990.
Epstein MA, Sperling MR, Stecker MM, O'Connor MJ: Anatomic correlates of
ictal tachycardia. Epilepsia 31:628, 1990.
Stafiniak P, Saykin AJ, Sperling MR, Robinson LJ, Gur RC, O'Connor MJ:
Recovery from anomia after dominant temporal lobectomy: One year follow up.
Epilepsia 32 (S) 3:91, 1991.
French JA, Pfeifer L, O'Connor MJ, Sperling MR: Historical factors differentiate
patients who are seizure-free after temporal lobectomy from other groups.
Epilepsia 32 (S) 3:91, 1991.
Saykin AJ, Sperling MR, Robinson LJ, Kester DB, Stafiniak P, Gur RC, O'Connor
MJ: Memory outcome of anterior temporal lobectomy: Acute changes and one
year follow up. Epilepsia 32 (S) 3:90, 1991.
Burgerman RS, French JA, O'Connor MJ, Sperling MR: Comparison of EEG
features and surgical outcome for mesial versus temporal neocortical seizures.
Epilepsia 32(S) 3:92, 1991.
Saykin AJ, O'Connor MJ, Robinson LJ, Kester DB, Gur RC, Sperling MR:
Unilateral memory during the intracarotid amobarbital test: Relation to outcome
of anterior temporal lobectomy. Epilepsia 32(S) 3:89, 1991.
Saykin AJ, O'Rourke DM, Robinson LJ, Kester DB, Bassey E, Sperling MR,
O'Connor MJ: Validity of the Intracarotid Amobarbital Memory Test (IAMT.
Journal of Clinical and Experimental Neuropsychology, 14(1):98, 1992.
Robinson LJ, Saykin AJ, Sperling MR, French JA, O'Connor MJ: Standardization
assessment of psychopathology in epilepsy surgical candidates. Epilepsia 33(1):
16, 1992.
Uruno K, O'Connor MJ, Masukawa LM: Presence of paired-pulse facilitation and
non-GABA-A paired pulse inhibition revealed by moderate to low intensity
stimulation in the dentate gyrus of epileptic patients. Soc. for Neurosci(Abst)
1992.
French JA, Saykin AJ, Pfeifer L, Sperling MR, O'Connor MJ: Early risk factor
predicts successful epilepsy surgery outcome. Epilepsia 33(S) 3: 27, 1992.
McGonigle P, Dai A, O'Connor MJ, Masukawa LM: Changes in glutamate
receptor binding and excitatory field responses in the dentate gyrus of epileptic
patients. Soc. of Neurosci(Abst) 1992.
Masukawa LM, Lynott J, Uruno K, O'Connor MJ: Comparison of synaptic
reorganization in anterior and posterior segments of the dentate gyrus in
temporal lobe epileptic patients. Epilepsia 33(3): 34, 1992.
Burgerman R, French JA, Saykin AJ, O'Connor MJ, Sperling MR: Comparison of
intracarotid amobarbital memory scores in patients with mesial versus neocortical
onset temporal lobe seizures. Epilepsia 33(S) 3: 87, 1992.
Sperling MR, Glosser G, Saykin AJ, French JA, O'Connor MJ: Intracarotid
amobarbital test predicts seizure relief after temporal lobectomy. Epilepsia
34(S)6: 70, 1993
O'Connor WM, Lynott J, Masukawa LM, Sperling MR, French JA, O'Connor MJ:
Anterior Cell Density vs. Posterior Cell Density in the Dentate Granule Cell Layer
of Patients who have undergone Temporal Lobectomy for Seizure Control.
Epilepsia 34(S)6:77, 1993.
Shaver E, O'Connor WM, Sperling MR, French JA, O'Connor MJ: Cell Loss in
the Dentate Granular Cell Layer and Hilus in Patients with Temporal Lobe
Epilepsy as a Function of Early Risk vs. No Early Risk Factors. Epilepsia
34(S)6:110, 1993.
Burgerman RS, French JA, O'Connor MJ, Sperling MR: A Comparison of
Historical Features in Patients with Mesial vs. Neocortical Onset Temporal Lobe
Seizures. Epilepsia 34(S) 6:33, 1993.
Saykin AJ, Maerlender AC, Moran M, O'Connor MJ, Gur RC, French JA, Sperling
MR: Level and pattern of changes in verbal learning after anterior temporal
lobectomy: Effect of early risk factors. Epilepsia 34(S)6:91, 1993.
Liporace JD, French JA, Sperling MR, O'Connor MJ, Moran M: Late Brain Injury
and Prognosis after Anterotemporal Lobectomy. Epilepsia 34(S)6: 89, 1993.
French JA, Sperling MR, O'Connor MJ, Liporace JD, Jacobson MP: New
Approach to Postresection EEG Recording: Long-Term Intracranial Monitoring.
Epilepsia 34(S)6: 124, 1993.
Freese A, O'Connor MJ, Kaplitt MJ, O'Connor WM, During MJ: AdenoAssociated Virus Vector Mediated Gene Transfer into Human Hippocampal
Slices. Epilepsia 35(S)8: 62, 1994.
Swanson TH, O'Connor MJ: Evidence that adenosine modulated synaptic
activity is altered in epileptic human dentate gyrus. Epilepsia 35(S)8: 40, 1994.
King JT Jr, Sperling MR, O'Connor MJ: Is anterior temporal lobectomy for
medically intractable temporal lobe epilepsy "cost-effective"?. Epilepsia 35(S)8:
46, 1994.
Sperling MR, Roberts D, Saykin AJ, French JA, O'Connor MJ: Occupational
outcome after anterior temporal lobectomy correlates with seizure control.
Epilepsia 35(S)8: 47, 1994.
Glosser G, Saykin AJ, Deutsch GK, Sperling MR, O'Connor MJ: Patterns of
reorganization of memory functions within and between cerebral hemispheres as
assessed by the intracarotid amobarbital test. Epilepsia 35(S)8: 80, 1994.
Deutsch GK, Saykin AJ, Sperling MR, Robinson LJ, O'Connor MJ: Metamemory
in temporal lobe epilepsy: underestimation of memory ability is associated with
depression. Epilepsia 35(S)8: 98, 1994.
McCarthy RJ, Sperling MR, O'Connor MJ: Secondary epileptogenesis in
refractory epilepsy. Epilepsia 35(S)8: 135, 1994.
Tatum WO, Sperling MR, O'Connor MJ, Jacobstein JG: Interictal spect as a
predictor of post-operative seizure relief in temporal lobe epilepsy. Epilepsia
35(S)8: 154, 1994.
Freese A, O'Connor MJ, Kaplitt MJ, O'Connor WM, During MJ: Adenoassociated virus vector mediated gene transfer into human hippocampal slices.
Annual Meeting of the American Epilepsy Society 3.14 (1994).
Freese A, Kaplitt MG, O'Connor MJ, O'Connor WM, During MJ: Gene transfer
into human hippocampal slices with an adeno-associated virus vector.
Proceedings 24th Annual Meeting, Society for Neuroscience, 592.15 (1994).
Zwil AS, Glosser G, Plummer CE, Wilson G, Sperling MR, O'Connor MJ:
Prospective psychiatric assessment before and after temporal lobectomy.
Epilepsia 36(S) 4, 1995.
Sperling MR, O'Connor MJ: Five-year outcome of temporal lobectomy for
refractory epilepsy. Neurology 45 (S) 4:A270, 1995.
Sirven JI, Sperling MR, French JA, O'Connor MJ: The localizing value of simple
partial seizures in evaluation for epilepsy surgery. Neurology 45(S) 4, A454,
1995.
Freese A, O'Connor, MJ, During MJ, Judy K, Davidson B: Adenovirus vectors
result in preferential transgene expression in dividing glial cells. International
Conference on Gene Therapy for CNS Disorders, 2.12 (1995).
Sperling MR, Liporace JD, French JA, Skolnick BE, O'Connor MJ: Epilepsy
surgery and mortality from epilepsy. Epilepsia 36:140, 1995.
Lippman C, Welsh F, Kaplitt MG, Abbey M, O'Connor WM, During MJ, O'Connor
MJ, Freese A: Transfer of human heat shock protein-72 into cultured CNS cells
using an adeno-associated virus vector. International Conference on Gene
Therapy for CNS disorders, 4.11 (1995).
Freese A, Langer D, Kaplitt MG, O'Connor MJ, O'Connor WM, During MJ: AAV
mediated gene transfer into human hippocampal slices. International
Conference on Gene Therapy for CNS disorders, 4.33 (1995)
Sperling MJ, Liporace JD, French JA, Skolnick BE, O'Connor MJ: Epilepsy
surgery and mortality from epilepsy. Epilepsia 36(S) 4, 1995.
Sirven JI, Detre J, French JA, Alsop DC, O'Connor MJ, Liporace J, Sperling MR:
Functional magnetic resonance imaging of simple partial and subclinial seizures
in the evaluation of epilepsy surgery patients. Epilepsia 36(S) 4:172, 1995.
Masukawa LM, Uruno K, Wang H, O'Connor MJ: Disinhibition of the dentate
gyrus from epileptic patients reveals paroxysmal field discharges. Epilepsia
36(S) 4, 1995.
Lippman C, Welsh F, Kaplitt MG, O'Connor WM, During MJ, O'Connor MJ,
Freese A: Adeno-associated virus mediated human heat shock protein 72 gene
transfer into neuronal cultures. 12th Annual Neuroscience Retreat, University of
Pennsylvania, 1995.
Swanson TH, Sperling MR, O'Connor MJ, Luders HO: Electrophysiologic
evidence for increased feedback and decreased feed forward inhibition in
epileptic human dentate gyrus. Epilepsia 36(S) 4:59, 1995.
Lippman C, Welsh F, Kaplitt M, O'Connor WM, During M, O'Connor MJ, Freese
A: AAV-Vector mediated human hsp-72 gene transfer into cultured cells.
Proceedings 25th Annual Meeting, Society for Neuroscience, 710.9 (1995).
Freese A, O'Connor MJ, Langer D, Kaplitt MG, O'Connor WM, During MJ: Gene
transfer into human hippocampal tissue using an adeno-associated virus vector:
Prospects for gene therapy in focal epilepsy. Annual Meeting of the Congress of
Neurological Surgeons, Abstract 748 (1995).
Lippman C, Welsh F, Kaplitt M, O'Connor WM, During M, O'Connor MJ, Freese
A: Demonstration of a direct neuroprotective function of human heat shock
protein-72 in cultured CNS neurons using an adeno-associated virus vector
expressing the hsp-72 gene. Annual Meeting of the American Association of
Neurological Surgeons. Abstract 1109. (1996).
Freese A, During MJ, Lowen G, O'Connor WM, O'Connor MJ, Davidson BL:
Adenovirus vector-mediated delivery of the tyrosine hydroxylase gene into striatal
cells: Implications for gene therapy in Parkinson's disease. Annual Meeting of
the American Association of Neurological Surgeons, Abstract 742 (1996).
Sirven J, Sperling M, Liporace J, French J, O'Connor M: Reliability of ictal
scalp/sphenoidal electroencephalogram in temporal lobe epilepsy. Neurology 46
(S): A123, 1996
Sperling MR, O'Connor MJ, Saykin AJ, Plummer C: Temporal lobectomy for
refractory epilepsy: Outcome five years after surgery. JAMA 278, No. 6, August
14, 1996.
Sperling MR, Sirven JI, Liporace JD, O'Connor MJ: Surgical treatment of
patients with bitemporal seizures in the scalp EEG. Epilepsia 37 (S) 5:179, 1996.
Sirven JI, Liporace JD, O'Connor MJ, Sperling MR: Prognosis of bitemporal
seizures in the intracranial EEG. Epilepsia 37 (S) 5:208, 1996.
Sirven JI, Liporace JD, O'Connor MJ, Sperling MR: Significance of intracranially
recorded independent bilateral temporal lobe seizures. Submitted to Am.
Epilepsy Soc.
Abbey M, Davidson BL, Cox R, Huirst R, Langer D, Riina H, O'Connor, MJ,
Freese A: Nitric oxide synthase gene transfer into human cerebral vascular
smooth muscle cells: Prospects for genetic intervention in vasospasm. Annual
Meeting of the American Association of Neurological Surgeons, Abstract 1036,
1997.
Freese A, Figuereo S, Wilensky R, During MJ, Riina H, O'Connor MJ, Hurst RJ:
Selective endovascular delivery of gene transfer systems into the Brain:
Prospects for targeting of gene therapy in neurological disorders. Annual
Meeting of The American Association of Neurological Surgeons, Abstract 1219,
1997.
Weil RJ, Liporace J, Sperling MR, O'Connor MJ: Multiple subpial transections in
eloquent cortex. Epilepsia 38(S) 3, 1997.
Weil RJ, Liporace J, Sperling MR, O'Connor, MJ: Combined frontal lobectomy
and callosotomy for complex frontal lobe seizures. Epilepsia 38(S) 3, 1997.
O'Connor WM, Davidson BL, Kaplitt MG, Abbey MV, During MJ, Leone P, Langer
D, O'Connor MJ, Freese A: Adenovirus vector mediated gene transfer into
human epileptogenic brain slices. 22nd International Epilepsy Congress
Proceedings. Epilepsia 38:203, 1997.
O'Connor MJ, Weil RJ, Liporace J, Freese A, Sperling MR: Multiple subpial
transections in eloquent cortex. Annual Meeting of the American Association of
Neurological Surgeons, Abstract 1289 (1998)
Buono RJ, Ferraro TN, Finanger EL, O'Connor MJ, Sperling MR, Ryan SG,
Abbey M, Berrettini WH: Genetic susceptibility of human epilepsy. Submitted
National Soc of Neuroscience, 1998
Veznedaroglu E, Sirven J, Liporace J, O'Connor MJ: Temporal lobe seizures
detected with intrahippocampal electrodes but not with subdural temporal strips.
Submitted to AANS August 6, 1998.
O'Connor MJ, Sperling MR, Liporace J, Sirven J, Barry E, Freese A: Results of
long term follow up of 405 temporal lobectomies over a twenty year period.
Annual Meeting of the American Association of Neurological Surgeons. Abstract
714 (1998).
Freese A, Young DD, Silver D, Liu CY, Davidson BL, O'Connor MJ, Leone P,
During MJ: Correlation between number of transduced cells and behavioral
recovery in a rat Parkinson's disease model following in vivo gene therapy.
Annual Meeting of the American Association of Neurological Surgeons. Abstract
825 (1998).
Freese A, O'Connor MJ, Leone P, Ness DJ, Xie H, During MJ: Genetic
intervention in an animal model of epilepsy: Effects of transfer of genes
encoding glutamic acid decarboxylase, a GABA receptor subunit, or glial cellderived neurotrophic factor. Annual Meeting of the American Association of
Neurological Surgeons. Abstract 1263, 1998.
Buono L, Azad S, Kline B, O'Connor MJ: An anesthetic technique for awake
craniotomies for neurosurgical procedures. Submitted to AANS August 6, 1998.
Veznedaroglu E, Sirven J, Liporace J, O'Connor MJ: Temporal lobe seizures
detected with intrahippocampal electrodes but not with subdural temporal strips.
Submitted to AANS 1999.
Sperling MJ, Carran MA, O'Connor MJ: Marital status after epilepsy surgery.
Submitted to Epilepsia 1999.
Abbey MV, Freese A, Bagasra O, O'Connor WM, Memoli M, Van Bockstaele E,
O'Connor MJ: In situ rtPCR: A novel approach towards evaluating gene
expression in human brain tissue. Annual Meeting of the American Association
of Neurological Surgeons, Abstract 1352, 1999.
Veznedaroglu E, Sperling M, O'Connor M, Sirven J, Liporace J: Evaluation of
Intrahippocampal and subdural strip electrodes for seizure localization. 53rd
Annual Meeting of American Epilepsy Society, December 1999.
O'Connor M, Sperling M, Liporace J, Sirven J, Freese A: Multiple subpial
transection: an adjunct to resective surgery for epilepsy in eloquent cortex. 53rd
Annual Meeting of American Epilepsy Society, December 1999.
Glosser, D, Warren S, Loughead J, O'Connor M, Liporace J, Nei M, Sperling M:
An analysis of Wada protocol variables and memory scores among TLE patients.
American Epilepsy Society, 54th Annual Meeting, December 2000.
O'Connor M, Goldberg E, Sperling M, Liporace J, Sirven J, Romeo A: Outcome
of corpus callosum section. Submitted American Epilepsy Society, April 2000
Editorials, Reviews & Chapters
Jobsis FF, O'Connor MJ, Vitale A, Vreman H: Intracellular redox changes in the
functioning cerebral cortex. In Neurophysiology studied in man. G.G.Somjen
Ed. International Congress Series. 253:18-26, 1972.
O'Connor MJ, Lewis DV, Herman CJ: Potassium effects on energy metabolism
and epileptiform activity in the cat hippocampus. Symposium on cerebral
circulation and metabolism. Cerebral Circulation and Metabolism., T.W. Langfitt,
L.C. Henry, M. Reivich, and H.Wollman, Eds. Springer-Verlag, New York, 514517, 1975.
Marsan C, O'Connor MJ: Electrocorticography. In Handbook of
Electroencephalography and Clinical Neurophysiology. 10 C: 1-49. A.Remond,
Ed. Elsevier Scientific Publishing Co., Amersterdam, 1975.
O'Connor MJ: The coupling of function, metabolism, and blood flow. Alfred
Benxon Symposium VIII. In Brain Work. D.H. Ingvar and N.A. Lassen, Eds.
Munksgaard, Copenhagen, 218-221, 1975.
O'Connor MJ: Origin of labile NADH tissue fluorescence. Oxygen and
Physiological function. F.F. Jobsis, Ed. 90-99, Professional Information Lib.,
Dallas, 1977.
Welsh FA, O'Connor MJ, Marcy VR, Rieder W: Two distinct types of
inhomogeneous metabolic failure in cerebral oligemia. Cerebral Function,
Metabolism and Circulation; D.H. Ingvar and N.A. Lassen, Eds. Munksgaard,
Copenhagen, Acta. Neur. Scan. 56: Supp. 64, 12-13, 1977.
O'Connor MJ: Changes in PO2 and Ion in cerebral hypoxia-ischemia. Tissue
Hypoxia and Ischemia. M. Reivich, R. Coburn, S. Lahiri, and B. Chance, Eds.
Advances in Experimental Medicine and Biology. 78:313-317, Press, NY, 1977.
Welsh FA, O'Connor MJ, Marcy V, Johns R: The appearance of regions with
irreversible energy failure at the threshold of ischemic damage in cat brain.
Cerebral Blood Flow and Metabolism. F. H. Naggai, Y. Tazaki, Eds.
Munksgaard, Copenhagen., Acta. Neuro. Scan. 60: Supp. 72, 280-281, 1979.
O'Connor MJ: Neurosurgical treatment of head trauma. Neural. Trauma., A.J.
Popp, R.S. Bourke, L.R. Nelson, H.K. Kimelberg, Eds., 341-345. Raven Press
Books Ltd., N.Y., 1979.
Lin SR, O'Connor MJ, King AN, Fischer HW: Evaluation of therapeutic
mechanisms of plasma expander and fibrinolytic agent following cardiac arrest.
An experimental study in the dog. Cerebral Blood Flow and Metabolism, F. H.
Naggai, Y. Tazaki, Eds . Munksgaard, Copenhagen., Acta.Neuro.Scan. 60:
Supp. 72, 1979.
O'Connor MJ: Cerebral metabolism in the acute, severe, head injured patient:
Primary metabolic depression vs. ischemic hypoxia. Clinical Neurosurgery,
Chapter 9, 29:146-161, 1982.
Ligeti L, Barlow C, Chance B, Kovach AGB, O'Connor MJ: 31-PNMR
spectroscopy of brain and heart. Oxygen Transport to Tissue, Chapter IV. pages
281-292, 1983. Ed. H. B. Bicher et al, Plenum Publishing, New York, New York.
O'Connor MJ, Barrer SJ, Welsh FA: Normal cerebral energy metabolism.
Neurosurgery. Wilkins, R.H., and Rengachary, S.S., McGraw-Hill, Inc. Vol. II,
pp. 1179-1184.
O'Connor MJ: Coupling of energy metabolism and ictal transformation.
Mechanisms of Epileptogenesis. Edited by Marc Dichter. Plenum Publishing
Co., pp. 199-203, 1989.
Saykin AJ, Gur RC, Sussman NM, O'Connor MJ, Gur RE: Memory deficits before
and after temporal lobectomy: Effect of laterality and age of onset. Brain and
Cognition, 9, pp. 191-200, Academic Press, Inc., 1989.
Saykin AJ, Robinson LJ, Stafiniak P, Kester DB, Gur RC, O'Connor MJ, Sperling
MR: Neuropsychological effects of temporal lobectomy: Acute changes in
memory, language, and music. T. Bennett (Ed) Neuropsychology of Epilepsy,
Plenum Publishing Co., New York, pp 263-290, 1992.
Sperling MR, O'Connor MJ: Electrographic correlates of spontaneous seizures.
In S.S. Spencer (Ed) Clinical Neuroscience, 2:17-46, 1994.
O'Connor MJ: Neocortical dynamics and human EEG rhythms, Nunez PL
(editor-in-chief), Cutillo BA, Gevins AS, Ingber L, Lopes da Silva FH, Pilgreen KL,
Silberstein RB (section editors). New York, Oxford University Press,
Neurosurgery 1995.
Masukawa LM, O'Connor WM, Burdett LJ, McGonigle P, Sperling MR, O'Connor
MJ, Uruno K: Mossy fiber reorganization and its possible physiological
consequences in the dentate gyrus of epileptic humans. Neuronal Regeneration,
Reorganization and Repair, F. Seil (Ed), Raven Press, 1996.
Masukawa LM, Burdette LJ, McGonigle P, Wang H, O'Connor W, Sperling MR,
O'Connor MJ, Uruno K: Physiological and anatomical correlates of the human
dentate gyrus: consequences or causes of epilepsy. Submitted to Basic
Mechanisms of the Epilepsies, Third Edition. Jasper (Ed.) 1996
Presentations
VanBuren JM, O'Connor MJ: The application of flurometric monitoring of cortical
metabolic activity in the surgical treatment of epilepsy. (Presented to the
American Association of Neurologic Surgery, 1972. Also given as Invited
Lecture for 30, Information Library, Dallas, TX., 1973.)
O'Connor MJ: Proposed control of seizures by neuronal electrogenic sodium
pump activity. (Presented to American Association of Neurologic Surgery,
1978.)
Ligeti L, Barlow C, Chance B, Kovach AGB, O'Connor MJ: 31-PNMR
spectroscopy of brain and heart. International Society for Oxygen Transport to
Tissue. 5th Int. Symposium. 1981. August 23-28, 1981. Detroit, Michigan.
O'Connor MJ: Defects in cerebral function and metabolism and the role of
revascularization. Annual Oration, Philadelphia Academy of Surgery, 1982.
Sussman NM, Gur RE, O'Connor MJ, Gur RC: Reduction in seizure frequency
and change in seizure type following corpus callosotomy. American Academy of
Neurology Meeting, April, 1983.
Barrer SJ, O'Connor MJ: Endarterectomy for internal carotid artery occlusion:
Predictive Factors. Presented at the 57th Annual Meeting of the American Heart
Assoc., Miami Beach, Florida, November 12-15, 1984.
Barry E, Sussman NM, O'Connor MJ: Temporal lobectomy for epilepsy:
Predictors of outcome. Presented at the AAN Scientific Program in April, 1985.
Barrer SJ, O'Connor MJ: Endarterectomy for complete internal carotid artery
occlusion: Predictive factors. Presented at the 8th International Congress of
Neurologic Surgery, Toronto, Canada, July 1985.
MODERATOR: Talk entitled, "Corpus Callosotomy", at the Meeting of the
Congress of Neurologic Surgeons, Waikiki, HI, October 1985.
Barry E, Sussman NM, O'Connor MJ, Harner R: Location of temporal lobe foci:
Predictor of outcome in temporal lobectomy. Submitted to AAN Scientific
Program, November 1985.
Sussman NM, Scanlon M, Garfinkle W, Callanan M, O'Connor MJ, Harner R:
Magnetic resonance imaging in post callosotomy patients. Submitted to AAN
Scientific Program, October 1987.
Zimmerman RA, Sperling MR, Bilaniuk LT, O'Connor MJ, Gonatas N, Hackney
DB, Grossman RI, Goldberg HI: MRI of mesial temporal sections. Presented at
the Radiologic Society of North America, Chicago, November 1987.
Sperling MR, O'Connor MJ: Depth electrodes are superior to subdural
electrodes in recording from the temporal lobe. Presented at Eastern
Association of Electroencephalographers, Mont Rolland, Quebec, Canada,
March 1988.
Alavi A, Sperling MR, Gur RC, Gur RE, Resnick S, O'Connor MJ: Subcortical
metabolic alterations in partial epilepsy. Submitted to the Society of Nuclear
Medicine, 35th Annual Meeting, June 1988.
O'Connor MJ, Sperling MR: Surgical treatment of epilepsy. Annual Meeting of
American Epilepsy Society, San Francisco, CA, October 1988.
Saykin AJ, Sperling MR, Reinicke LJ, Kester DB, O'Connor MJ, Gur RC:
Neuropsychological prediction of seizure outcome in anterior temporal lobectomy
candidates. Int.Neuropsych.Society, Orlando, Florida, 1990
O'Rourke DM, Gilhool JJ, Saykin AJ, Sperling MR, O'Connor MJ, Coleman P:
Quantitative hippocampal histology in temporal lobe epilepsy patients: correlation
with early risk for brain injury. Presented at the American Association of
Neurological Surgeons, New Orleans, LA, April 1991.
O'Rourke DM, Gilhool JJ, Saykin AJ, Sperling MR, O'Connor MJ, Coleman P:
Relation of lateralized memory impairment and quantitative hippocampal
histology in temporal lobe epilepsy. Presented at the American Association of
Neurological Surgeons, New Orleans, LA, April 1991.
West SL, Doty RL, O'Connor MJ, Sperling MR: Pre and post-operative studies of
olfactory function in patients with anterior temporal lobectomy. For presentation
at the American Chemical Society.
Saykin AJ, O'Rourke DM, Robinson LJ, Kester DB, Bassey E, Sperling MR,
O'Connor MJ: Validity of the Intracarotid Amobarbital Memory Test (IAMT).
International Neuropsychology Society, San Diego, CA
O'Connor WM, Lynott J, Masukawa LM, Sperling MR, French JA, O'Connor MJ:
Anterior Cell Density vs. Posterior Cell Density in the Dentate Granule Cell Layer
of Patients who have undergone Temporal Lobectomy for Seizure Control.
Accepted for Platform Presentation, Annual Meeting, American Epilepsy Society,
December 3-9, 1993, Miami, Florida.
Shaver E, O'Connor WM, Sperling MR, French JA, O'Connor MJ: Cell Loss in
the Dentate Granular Cell Layer and Hilus in Patients with Temporal Lobe
Epilepsy as a Function of Early Risk vs. No Early Risk Factors. Accepted for
Poster Presentation at the Annual Meeting of the American Epilepsy Society,
December 3-9, 1993, Miami, Florida.
Burgerman RS, French JA, O'Connor MJ, Sperling MR: A Comparison of
Historical Features in Patients with Mesial vs. Neocortical Onset Temporal Lobe
Seizures. Accepted for Poster Session, Annual Meeting of the American
Epilepsy Society, December 3-9, 1993, Miami, Florida.
Saykin AJ, Maerlender AC, Moran M, O'Connor MJ, Gur RC, French JA, Sperling
MR: Level and pattern of changes in verbal learning after anterior temporal
lobectomy: Effect of early risk factors. Accepted by American Epilepsy Society
for Poster Presentation, December 3-9, 1993, Miami, Florida.
Burr RB, Saykin AJ, O'Connor MJ, Sperling MR: Material specific improvement
in memory following anterior corpus callosotomy. Submitted to International
Neuropsychological Society, 22nd Annual Meeting, Cincinnati, OH, July 1993.
Freese A, Kaplitt MJ, O'Connor MJ, O'Connor WM, During MJ: Gene Transfer
into Human Hippocampal Slices with an Adeno-Associated Virus Vector.
Submitted to Society for Neuroscience Annual Meeting, Miami Beach, Florida,
November 13-18, 1994.
Sperling MR, Manno EM, Alavi A, Jaggi J, Ding S, Reivich M, O'Connor MJ:
PET-FDG predicts outcome after anterior temporal lobectomy. For presentation
at the American Academy of Neurology, May 1994.
Glosser G, Saykin AJ, Sperling MR, O'Connor MJ: Dissociations between object
and action naming following anterior temporal lobectomy. For presentation at the
Aphasia Annual Meeting, October 1994.
Deutsch GK, Glosser G, Corwin J, Saykin AJ, Sperling MR, O'Connor MJ:
Lateralization of memory discrimination and response bias during the intracarotid
amobarbital test (IAT). Submitted for presentation the International
Neuropsychological Society Meeting, February 1995.
Deutsch GK, Glosser G, Corwin J, Saykin AJ, Sperling MR, O'Connor MJ:
Lateralization of memory discrimination and response bias during the intracarotid
amobarbital test: Presented at the International Neuropsychological Society
Meeting, February 1995.
Lippman C, Welsh F, Kaplitt MG, O'Connor Wm, During MJ, O'Connor MJ,
Freese A: Adeno-associated virus mediated human heat shock protein 72 gene
transfer into neuronal cultures. 12th Annual Neuroscience Retreat, University of
Pennsylvania, 1995.
Freese A, O'Connor MJ, Langer D, Kaplitt MG, O'Connor WM, During MJ: Gene
transfer into human hippocampal tissue using an adeno-associated virus vector:
Prospects for gene therapy in focal epilepsy. Annual Meeting of the Congress of
Neurological Surgeons, 1995.
Freese A, O'Connor WM, Lippman C, O'Connor MJ, During MJ, Kaplitt MG,
Davidson B: Preferential transgene expression in dividing glial cells using
adenovirus vectors: Implications for CNS gene therapy. Annual Meeting of the
Congress of Neurological Surgeons, Abstract 310 (awarded first prize for posters
in category) (1995).
Talk entitled, "Cervical Problems, particularly disc & stenosis", given at
Rheumatology Conference, February 29, 1996.
Talk entitled, "Surgical Options in Epilepsy when Medicine Fails" at The 8th PanPhiladelphia Neurosurgery Conference, Rittenhouse Hotel, Philadelphia, PA,
October 25, 1996.
Abbey M, Davidson BL, Cox R, Hurst R, Langer D, Riina H, O'Connor MJ,
Freese A: Nitric oxide synthase gene transfer into human cerebral vascular
smooth muscle cells: Prospects for genetic intervention in vasospasm. Annual
Meeting of the American Association of Neurological Surgeons, Abstract 1036
(1997).
Talk entitled, "Epilepsy Surgery: Several Years of Clinical Experience", at
Neurology Grand Rounds, Thomas Jefferson University Hospital, Philadelphia,
PA, February 13, 1998.
Talk entitled, "Surgical Management of Epilepsy", at the Twenty-fifth Annual
Course in Electrodiagnosis and Clinical Neurophysiology, Jefferson Medical
College, Philadelphia, PA, March 5, 1998.
Panelist in Breakfast Seminar entitled "Surgical Options in Epilepsy" at American
Association of Neurological Surgeons in New Orleans, LA, April 29, 1999.
Buono LM, O'Connor MJ: Poster presentation "Bolus controlled anesthesia in
awake craniotomy" at Annual Meeting American Epilepsy Society, December
1999.
Sperling MR, Lovitz LE, Malamut BL, Liporace JD, Sirven JI, O'Connor MJ:
Poster presentation "Seizure Recurrence after Temporal Lobectomy: A Survival
Analysis" at Annual Meeting American Epilepsy Society, December 1999.
Lovitz LE, Sperling MR, Liporace JD, Sirven JI, O'Connor MJ: Poster
presentation "The Prognostic Value of Auras After Temporal Lobectomy" at
Annual Meeting American Epilepsy Society, December 1999.
Neurology Grand Rounds, Thomas Jefferson University, "Hippocampal Changes
in Epilepsy", February 4, 2000.
Talk entitled "Hippocampal Reorganization in Epilepsy" given at Grand Rounds,
Department of Neurosurgery, Medical College of Wisconsin, March 10, 2000.
Sperling MR, Lovitz L, Liporace J, Sirven J, O'Connor MJ: Quality of life after
temporal lobectomy. Accepted by American Association of Neurological
Surgeons for Poster Presentation, April 2000.
O'Connor MJ, Goldberg E, Sperling MR, Liporace J, Sirven J, Romeo A:
Outcome of corpus callosum section. Accepted by American Association of
Neurological Surgeons for Poster Presentation, April 2000.
Presentation entitled "Opening Anatomic Doors for Epilepsy Surgery" given at
the Congress of Neurological Surgeons Annual Meeting, September 25, 2000 in
San Antonio, TX.
O'Connor MJ, Goldberg E, Sperling MR, Liporace J, Sirven J, Romeo A:
Outcome of corpus callosum section. Accepted by American Epilepsy Society
for Poster Presentation, December 5, 2000.
Talk entitled "Surgical Intervention in Epilepsy" presented at the Meigs Society
Meeting on February 15, 2001, Philadelphia, PA.