Curriculum Vitae
(Last updated: 2015-12-22)
HEE YOUNG SEOK, Ph.D.
Education and Training
2004-2011
Ph.D. in Cell and Developmental biology
University of North Carolina at Chapel Hill, Chapel Hill, USA
2003-2004
M.S. in Biochemistry
Virginia Polytech Institute and state University, Blacksburg, USA
2000-2002
M.S. in Biology
Ewha Womans University, Seoul, Korea
1996-2000
B.S. in Chemistry
Ewha Womans University, Seoul, Korea
Professional Experiences
2015-present
Research Professor
Institute of life sciences and biotechnology, Korea University, Seoul, Korea
2014-2015
Senior Research Scientist
SHAIST (Samsung Advanced Institute for Health Sciences & Technology)
/Sungkyunkwan University, Seoul, Korea
2012-0213
Research Fellow
Department of Cardiology, Harvard Medical School, Boston, USA
Department of Cardiology, Boston Children’s Hospital, Boston, USA
2009-2012
Research Assistant
Department of Cardiology, Boston Children’s Hospital, Boston, USA
Grant
1. Basic Science Research Program-Small Grant for Exploratory Research (2014-2017)
Understanding of the novel epigenetic RNA under stress induced cardiac plasticity
(NRF-2014R1A1A2A16055016)
YEAR
2014-2015
2015-2016*
2016-2017*
Grant
39,000,000
102,960,000
102,960,000
*: Selected finalist from 1st year trial will receive increased amount of research fund for next research years.
Publications
1. Seok HY, Ronal Neppl, Chen JH, Chen JF, Jin SW, Mably, J. and Wang DZ. Regulation of cardiomyocyte
proliferation and heart development by RNA helicase Csm. 2015. In preparation.
2. Mao Nie, Jianming Liu, Qiumei Yang, Hee young Seok, Xiaoyun hu, Zhong-Liang deng and Da-Zhi Wang.
MicroRNA-155 facilitates skeletal muscle regeneration through modulating macrophage phenotype
transition., 2015 Revision
3. Hye-Sook Lee, Heeyoung Seok, Dong Ha Lee, Juyoung Ham, Emilia M. Youm, Jin Seon Yoo, Wooje Lee,
Yong-Seung Lee, Eun-Sook Jang, and Sung Wook Chi. Abasic pivot substitution harnesses target
specificity of RNA interference. Nat Commun., 2015 Dec 18; 6:10154.
4. Seok HY, Chen JH, Kataoka M, Zhan-Peng Huang, Yan L, Xiaoyun Hu and Wang DZ. Loss of microRNA
155 protects the heart from pathological cardiac hypertrophy. Circulation Research, 2014 May
9;114(10):1585-95.
5. Chen J, Huang ZP, Seok HY, Ding J, Kataoka M, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R,
Wang DZ. mir-17-92 cluster is required for and sufficient to induce Cardiomyocyte proliferation in
postnatal and adult hearts. Circulation Research. 2013 Jun 7;112(12):1557-66
6. Huang ZP, Chen J, Seok H, Zhang Z, Kataoka M, Hu X, Wang DZ MicroRNA-22 Regulates Cardiac
Hypertrophy and Remodeling in Response to Stress. Circulation Research. 2013 Apr 26;112(9):123443.
7. Zhan-Peng Huang, Hee Young Seok, Bin Zhou, Jinghai Chen, Jian-Fu Chen, Yazhong Tao, William T. Pu
and Da-Zhi Wang. CIP, a novel cardiac Isl1-associated protein, represses cardiomyocyte hypertrophy.
Circulation Research. 2012 Mar 16; 110(6):818-30.
8. Seok HY, Tatsuguchi M, Callis TE, He A, Pu W, Wang DZ. miR-155 inhibits the expression of MEF2A to
repress skeletal muscle differentiation. J Biol Chem. 2011 Aug 25.
9. Seok HY, Wang DZ. The emerging role of microRNAs as a therapeutic target for cardiovascular disease.
BioDrugs. 2010 Jun; 24(3):147-55.
10. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J,
Willis MS, Selzman CH, Wang DZ. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction
in mice. J Clin Invest. 2009 Sep; 119 (9):2772-86.
11. Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ.
Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell
Cardiol. 2007 Jun; 42(6):1137-41. Epub 2007 Apr 14.
12. Kim JE, Seok HY, Karki P, Lee JS, Shin SY, Cho B, Park IS. Comparative study of apoptosis induced by
H(2)O(2) and NO: limitation of apoptosis induced by NO due to slower recovery of activity of NOmodified caspase. Protein Pept Lett. 2006; 13(4):401-4.
13. Park IS, Moon HR, Seok H, Lee M. Rearrangement of tryptophan residues in caspase-3 active site upon
activation. Biochim Biophys Acta. 2004 Jul 1; 1700 (1):5-9.
14. Seok HY, Cho J, Cheon M, Park IS., Biochemical characterization of apoptotic cleavage of KH-type
splicing regulatory protein (KSRP)/far upstream element-binding protein 2 (FBP2). Protein Pept Lett.
2002 Dec; 9 (6):511-9.
15. Kyoung M, Kim SY, Seok HY, Park IS, Lee M. Probing the caspase-3 active site by fluorescence lifetime
measurements. Biochim Biophys Acta. 2002 Jul 29; 1598 (1-2):74-9.
Presentations
1. Hee Young Seok, Ronald Neppl, Scott Hammond, Suk-Won Jin, John Mably and Da-Zhi Wang.
Weinstein Cardiovascular Development Conference: Cincinnati, OH (2011). Poster presentation.
2. Hee Young Seok, Ronald Neppl, Scott Hammond, Suk-Won Jin, John Mably and Da-Zhi Wang.
Genetics Retreat, Harvard Medical School, Cambridge, MA (2011). Featured speaker selected
3. Hee Young Seok, Ronald Neppl, Scott Hammond, Suk-Won Jin and Da-Zhi Wang. Weinstein
Cardiovascular Development Conference: San Francisco, CA (2009). Platform presentation selected
(Ronald Neppl presented)
4. Hee Young Seok, Edward Flynn, Scott Hammond, Suk-Won Jin and Da-Zhi Wang. Developmental
Biology Symposium, Chapel hill, NC (2007). Poster presentation
5. Hee Young Seok, Mariko Tatsguchi, Jian-Fu Chen, Dong-sun Cao and Da-Zhi Wang. Vascular
symposium, Chapel Hill, NC (2006). Poster presentation.
6. Hee Young Seok, Mariko Tatsguchi, Jian-Fu Chen, Dong-sun Cao and Da-Zhi Wang. Weinstein
Cardiovascular Development Conference, 2006, Tempa, FL (2006). Poster presentation.