RESEARCH IMPACT Contents Vice-Chancellor’s introduction .............. 2 Deputy Vice-Chancellor (Research) introduction ............................................... 3 World rankings.......................................... 4 Research at a glance............................... 5 Research excellence................................ 6 Funding success....................................... 8 Global challenges..................................... 9 Addressing state economic priorities....................................................10 Institutes .................................................. 12 Centres .................................................... 14 Fellowships and awards ....................... 16 Research impact .................................... 18 Our researchers .................................... 36 Next generation researchers .............. 44 Collaborations........................................ 52 CRICOS 00123M © The University of Adelaide. Published December 2015 2246-1 Research impact: the demonstrable contribution that research makes to the economy, society, culture, public policy, health, the environment, or quality of life Research Impact 1 They respond to emerging global and national research priorities, they have access to high quality research facilities and they are surrounded by highly talented researchers and higher degree students. Outstanding research universities share some common characteristics. The University of Adelaide possesses these traits, and is committed to innovation and continuing the pursuit of research excellence. From the University’s earliest days, the discovery of new knowledge has been at the core of its mission. Today our global impact is reflected in the University’s position within Australia’s Group of Eight leading research intensive universities and our consistent ranking in the top 1% of universities in the world. Indeed in 2014 we saw sharply improved positions in all three of the leading ranking tables. Pursuing excellence is also reflected in the research income of $182 million in 2014–as well as the quality of our staff. The University enjoyed another successful year in grant funding in 2014, receiving a record number of Australian Research Council (ARC) Future Fellowships ($8.4 million for 11 new projects) and a total $34.5 million from the ARC and over $33 million 2 Research Impact in National Health and Medical Research (NHMRC) funding. This represented over 60% of the funding awarded to South Australia under the two major government schemes. Our impact in health and medical research is also being boosted with the construction of the $206 million Adelaide Health and Medical Sciences building which will take the University’s research strength in Adelaide’s West End to over 1100 people–the largest research presence in the South Australian Health and Biomedical Precinct. Research impact is also measured by its commercial application. Record research commercialisation activity saw the University positioned within the top four for contract/ commercialisation revenue in 2013. The following report provides a glimpse of the talent and drive of the researchers who continue to deliver these world-class research outcomes. Professor Warren Bebbington Vice-Chancellor and President This may be in the form of a new medical procedure to alleviate chronic pain, a new device to provide more efficient power generation, a greater understanding of the thoughts and influences that drive group behaviour; or new uses of drone technology in agriculture and environmental monitoring. One of the most important aspects of a university is the way in which it can benefit society with the fruits of its endeavours, both tangible and intangible, and improve people’s lives. To do this successfully in an increasingly competitive environment, we work individually and collectively to ensure that our research is of high quality, supporting research excellence with judicious co-investment and a visionary outlook. This stretches from fundamental basic research, such as investigating the nature of dark matter, to more applied applications, such as a new gel to stem bleeding and heal wounds more quickly. Supporting research quality and the achievement of research outcomes in areas of societal and technological need is fundamental to our mission. Much of the research conducted at the University of Adelaide today focuses on addressing ‘grand challenges’, whether it be the challenge of feeding our expanding global population, sustaining our environment, achieving a healthier society or creating sustainable energy sources. As examples, our researchers are developing improved vaccines and novel treatment strategies for infectious diseases; enhancing the profitability and sustainability of smallholder vegetable farmers in Vietnam; and utilising microalgae for a variety of applications, including the development of renewable fuels. Looking through the stories contained in this report, and reflecting on the breadth and depth of the talent and expertise that abounds at the University, I can only admire greatly our talented researchers and feel deeply privileged to work in such an environment. Professor Mike Brooks Deputy Vice-Chancellor and Vice-President (Research) Research Impact 3 World rankings In 2015 the University of Adelaide was ranked: 149 169 113 in the world in The Times Higher Education World University Rankings 2015 4 Research Impact in the world by the Shanghai Jiao Tong Academic Ranking of World Universities 2015 in the 2015 QS World University Rankings. Research at a glance 1% Consistently ranked in the top of the world’s universities 5 research institutes Over $182m research income in 2014 Top 4 in Australia for contract research and commercialisation activity in 2013 50 Over research centres Awarded 67% of total Australian National Health and Medical Research Council project grant funding in SA for 2014 Highest amount of Research and Development Corporation funding in Australia in 2013 Awarded 60% of total Australian Research Council discovery project grant funding in SA in 2014 109 Rhodes Scholars (to date) 21 22 1,705 2,479 out of research areas rated at or above world class (2015) research students in 2014 academic research staff 386 postgraduate research students completed in 2014 Research Impact 5 Research excellence Excellence in Research for Australia (ERA) is an initiative of the Australian Government, which aims to assess research quality using a combination of metrics focussed on researchers, research outputs, research income, esteem and applied measures. The results released in December 2015 confirm many of the University’s fundamental research strengths, in areas including geology, ecology, oncology, nutrition, civil engineering, astronomical sciences, macromolecular chemistry, soil sciences and philosophy. >> 35 research sub-fields (52%) were awarded the maximum rating of 5, the second highest proportion in the Go8. >> 20 research sub-fields (30%) were rated above world standard (4 rating). >> 11 research sub-fields have now received a 5 rating across all three ERA rounds (2010, 2012 and 2015). 6 Research Impact >> The University is the only institution in Australia to achieve a 5 rating in Paediatrics and Reproductive Health across all three ERA rounds. The University’s research institutes align well with ERA high performers, with each of the institutes associated with multiple top rating of 5 in at least one research area. Institute Example of research sub-fields with top rating of 5 Institute for Photonics and Advanced Sensing Optical Physics; Macromolecular and Materials Chemistry Waite Research Institute Plant Biology; Soil Science Institute for Mineral and Energy Resources Geology; Mechanical Engineering Robinson Research Institute Paediatrics and Reproductive Health; Clinical Sciences Environment Institute Environmental Science and Management; Ecology Examples of research projects in some of our ‘5’ rated sub-fields include: Research sub-field Research example Mechanical Engineering Developing clean combustion and transforming biomass into bio-diesel, ethanol or di-methyl ether. Neurosciences Identifying genes and understanding the molecular mechanisms leading to intellectual disabilities, autisms and some epilepsies. Optical Physics Creating an “optical dog’s nose”, which uses a special laser to measure the molecular content of a sample of gas, allowing onsite breath analysis for disease. Paediatrics and Reproductive Health Identifying a key sensing molecule that controls the timing of birth, which is expected to generate new therapies to prevent preterm labour. Nanotechnology Using nanotechnology and the fossils of single-celled algae to develop a novel chemical-free and resistance-free way of protecting stored grain from insects. Research Impact 7 Funding success The University attracts research income from a wide variety of sources, although our major contributors remain Commonwealth Government agencies, particularly the Australian Research Council and the National Health and Medical Research Council. This funding is used to generate research outcomes across a broad variety of disciplines. Some examples from 2014 include: 13M $ over five years 2.7M $ ARC Australian Laureate Fellowship 8.8M $5M $ over five years The University was also awarded a prestigious ARC Australian Laureate Fellowship for Professor Alan Cooper, Director of the University’s Australian Centre for Ancient DNA. Professor Cooper has made a series of pioneering advances in evolutionary biology. He was one of just 16 researchers to receive this prestigious award, and the only successful applicant in South Australia. The NHMRC awarded a significant Program Grant, worth approximately $8.8M over five years, for a team led by Professor James Paton. The aim of the program is to improve understanding of the interactions between major disease-causing microbes and their human hosts, leading to the development of improved vaccines and novel treatments for infectious diseases. The University’s Centre for Traumatic Stress Studies was chosen by the Department for Veteran’s Affairs to lead the $5M Transition and Wellbeing Research Program, the objective of which is to investigate the mental health and wellbeing of contemporary armed service personnel and veterans. 8.5M The Australian Centre for International Agricultural Research provided over $8.5M for 17 new projects, ranging from fruit and vegetable production systems in Indonesia to sustainable vegetable farming in Vietnam, with the largest support of $2.8M for vegetable post-harvest management and productivity in Cambodia and Laos. 6.1M The Grains Research and Development Corporation provided funding worth over $6.1M across 11 new projects in 2014. This included major support (over $2M each) for improving weed management practices for emerging weeds, and research into late-maturity alpha-amylase (a genetic defect) in wheat. $ $ over 11 new projects 1.5M $ over 18 new projects 3.2M $ 8 Research Impact The University was awarded more than $6.8M to establish two new ARC Industrial Transformation Research Hubs: Genetic Diversity and Molecular Breeding for Wheat in a Hot and Dry Climate, and Australian Copper-Uranium. The hubs have attracted a further $6.25M in industry and collaborative support, bringing the total funding to more than $13M over five years. The Grape and Wine Research and Development Corporation awarded approximately $1.5M across 18 new projects in 2014, with key research projects including development of an under-vine floor management system, and translation of wine science research to industry outcomes. The Movember Foundation and the Prostate Cancer Foundation of Australia awarded the University $3.2M for a three-year, world-first project to help quickly distinguish life-threatening cases of prostate cancer from cancer that may not require treatment. The project is led by Associate Professor Lisa Butler, School of Medicine, and based in the SAHMRI Cancer Theme, working with an international research team. Global challenges The University of Adelaide is committed to expanding its research outputs. Its research institutes and centres address national, state and global priorities, focusing on key challenges of critical value to society. The global challenges that the University is addressing include: > food security > the management of natural resources, both terrestrial and marine > the development of sustainable energy sources > healthy people and populations > adapting to and mitigating climate change > cyber security Research Impact 9 The University of Adelaide addressing state economic priorities In August 2014 the South Australia Premier announced the State’s top 10 economic priorities to shape the future of SA. This section provides examples of the ways in which University of Adelaide researchers are contributing to State objectives. Priority 1: Unlocking the full potential of South Australia’s resources, energy and renewable assets Priority 2: Premium food and wine produced in our clean environment and exported to the world Copper is one of Australia’s top commodity exports and South Australia is a significant copper producer. With federal government and industry funding, the University has established an ARC Industrial Transformation Research Hub dedicated to Australian CopperUranium. This hub will help the Australian mining services industry by producing new, economically sustainable technologies that will be utilised by industry locally and exported internationally. Dr Matthew Tucker, a 2014 ARC Future Fellow, is working on ways to change the developmental path of grain in cereal crops to influence yield, quality and end-use. One outcome could be increased antioxidant levels in wholegrain or wholemeal flour, with the ultimate aim to develop a sustainable way of growing healthier foods. Priority 3: A globally recognised leader in health research, ageing and related services and products The Freemasons Foundation Centre for Men’s Health, jointly funded by the University and the Freemasons Foundation, is one example of a targeted approach to solving specific health issues. In this case, the multidisciplinary focus is on healthy male ageing, health literacy, screening and prevention and men’s use of and provision of health services. Particular attention is given to socioeconomically disadvantaged men and men in rural and remote locations. 10 Research Impact Priority 4: The ‘knowledge state’ – attracting a diverse student body and commercialising our research Since 2013 the University has added an additional 40 postgraduate research scholarships for international students, helping to attract a diverse student body. In 2014, the University attracted over $41 million in contract research, consultancy and commercialisation income - its best year ever. Priority 5: South Australia – a growing destination choice for international and domestic travellers The majority of Australia’s wine exports originate in South Australia, with wine regions and cellar doors creating a major tourist attraction. The University is the Southern Hemisphere’s premier wine research and teaching institution, and has a long established training centre at its Waite Campus – focused on innovative wine production – to help the wine industry tackle its big challenges. Priority 6: Growth through innovation The emerging convergence of nanoscience and photonics offers the opportunity of using light to interrogate nanoscale domains, providing unprecedentedly localised measurements. The University hosts the Centre for Nanoscale Biophotonics, which brings together physicists, chemists and biologists focused on controlling nanoscale interactions between light and matter to probe the complex and dynamic nanoenvironments within living organisms. Priority 7: South Australia – the best place to do business As part of an ARENA project on solar energy storage system, the Centre for Energy Technology is working with the State Government, SA Power Networks, the Energy Networks Association and companies Solar Storage, ZEN Energy Systems and Power and Drive Solutions. With strong private sector support, the project will help foster the State’s advanced manufacturing expertise. Priority 8: Adelaide – the heart of the vibrant state Construction has begun on the University’s new Adelaide Medical and Nursing Schools, which will support over 2500 students and health sciences researchers in the new South Australian Health and Biomedical Precinct. The vision for the building is ‘transforming health’ in the areas of education, research and patient care, by taking programs into the future with state-of-the-art facilities, the incorporation of new teaching styles and latest technologies. Priority 9: Promoting South Australia’s international connections and engagement Priority 10: South Australia’s small businesses have access to capital and global markets The Photonics Catalyst Program is a joint initiative between the Department of State Development and the University of Adelaide. Its aim is to connect South Australian industry with emerging laser and sensor technologies capable of transforming their businesses. It creates an SAbased ecosystem of expertise and capabilities in photonics to support the development of cutting edge products. ARC Australian Laureate Fellow Professor Alan Cooper has long been the driving force behind the strategic growth of evolutionary biology research in South Australia. He leads the internationallyrecognised Australian Centre for Ancient DNA, which attracts a constant stream of high-profile international and national visitors and researchers, who come to collaborate and utilise his team’s expertise in key areas of ancient DNA and evolutionary biology. Research Impact 11 Institutes The University’s institutes bring together world-leading researchers from multiple disciplines, supported by modern infrastructure and an innovative culture, to tackle global research challenges. 12 Research Impact Environment Institute Focus: solving complex environmental challenges and developing the collective approaches needed to do this. www.adelaide.edu.au/ environment/ The Environment Institute creates and leads large-scale research initiatives which aim to deliver globally competitive solutions to environmental problems. Research undertaken within the institute delivers know-how and understanding that will underpin a step-change improvement in the management of natural resources, such as water, soil, land and native flora and fauna, particularly under changing climate and economic conditions. Robinson Research Institute Institute for Photonics and Advanced Sensing Focus: health and medical research in human reproduction, pregnancy and child health under four key research themes. These are: fertility and conception, pregnancy and birth, early origins of health, and child andadolescent health. Focus: a transdisciplinary approach that brings together experimental physicists, chemists, material scientists, biologists, engineers and medical researchers to create new sensing and measurement technologies. www.adelaide.edu.au/robinsonresearch-institute/ www.adelaide.edu.au/ipas/ The Robinson Research Institute comprises a talented group of more than 350 researchers and clinicians, focusing on creating life and sustaining health. By focusing on the earliest stages of life, the Robinson Research Institute is looking at preventing disease and promoting health in children and adults across generations. The institute bridges the gap between research discoveries and medical practice with many of the institute’s senior researchers also being leading clinicians in their fields. Institute for Mineral and Energy Resources Focus: unconventional energy resources, deep exploration and deep mining, complex ore processing, reliable low-cost and low-emission energy technologies. www.adelaide.edu.au/imer/ IMER is designed to address one of the biggest challenges facing Australia: to continue to grow the economically critical mineral and energy resources industries in a technically, economically, socially and environmentally sustainable manner. The institute provides integrated research, education, professional development and consulting services across all aspects of the industries, from exploration to processing to international trade. The institute is developing novel photonic, sensing and measurement technologies that will change the way science is done within traditional discipline areas, stimulating the creation of new industries, and inspiring a new generation of scientists to be engaged in solving real world problems. IPAS research targets application in four key market areas: defence and national security, environmental monitoring, preventative health, and food and wine. Waite Research Institute Focus: plant genetics and genomics, crop development, viticulture and oenology, food and nutrition, natural resource management. www.wri.edu.au The Waite Research Institute brings together researchers from a range of disciplines including plant biology, genetics, soil sciences, agronomy and agricultural economics. Research undertaken with the institute aims to find solutions to global problems, including the challenge of ensuring global food security, and ensuring Australia’s agricultural wine and food industries remain competitive by providing innovative, researchled developments. Research Impact 13 Centres Centres of Excellence The University of Adelaide is proud to host and partner a number of National Research Centres, funded by the Commonwealth Government and research organisations: Australian Research Council (ARC) ARC Centre of ARC Centre of Excellence in Plant Excellence for Energy Biology (partner) Particle Physics at the The centre seeks to better Terascale (partner) understand the way in which plants produce and use their energy systems in response to environmental change, and focuses on unlocking the secrets of plant energy metabolism. This information is provided to plant breeders and geneticists to help them get the best out of plants. ARC Centre of ARC Centre of Excellence Excellence for Nanoscale for the History of Biophotonics (lead) Emotions (partner) The centre brings together physicists, chemists and biologists focused on controlling nanoscale interactions between light and matter to probe the environments within living organisms. ARC Centre of Excellence in Plant Cell Wall Biology (lead) The centre’s mission is to advance fundamental scientific understanding of plant cell wall biology to enable sustainable biomass production for food security, human health and energy biomass conversion. 14 Research Impact The centre uses historical knowledge from Europe, from the years 100 – 1800, to understand the long history of emotional behaviours. Emotions shape individual, community and national identities and the centre applies this knowledge to improve the social, cultural and emotional welfare of modern Australians. ARC Centre of Excellence for Robotic Vision (partner) One of the main objectives of the Centre is to develop key enabling technology to create robots that see and understand their environment, with the aim of allowing robotics to transform labour-intensive industries, disrupt stagnant markets, and ensure robots become a ubiquitous feature of the modern world. The centre (CoEPP) coordinates terascale, high-energy and particle physics research. Bringing together theoretical and experimental physicists, CoEPP’s research includes the prospect of understanding the origin of mass, discovering new physical laws, and producing and studying dark matter in the laboratory. Australian Centre for Plant Functional Genomics The centre focuses on improving the tolerance of wheat and barley to environmental stresses, such as drought and salinity, and researching ways to make plants use nutrients more efficiently. ARC Centre of Excellence for Mathematical & Statistical Frontiers (partner) The centre is focused on delivering real outcomes from world-leading research in mathematical and statistical theory and methods, and using these to address challenging scientific problems in the real world. National Health and Medical Research Council (NHMRC) Centres of Research Excellence Centre of Research Excellence for the Protection of Pancreatic Beta Cells (lead) The overall aim of the centre is to examine the gene-environment interactions and modifiable environmental exposures driving the development of islet autoimmunity and progression to Type 1 diabetes, an autoimmune disorder that results in the destruction of the pancreatic beta cells. Centre of Research Excellence in Translating Nutritional Science to Good Health (lead) Centre of Research The centre focuses on four primary Excellence in Aboriginal areas of research: diabetes, Chronic Disease obesity, nutrition in the elderly, and those with critical illness. It brings Knowledge Translation together a range of researchers and Exchange (lead) – including clinical investigators, basic scientists, nutritionists, leaders in primary health care, nurses and health psychologists – with the aim of preventing diseases by improving people’s nutrition. Foods for Future Australians Centre of Research Excellence (lead) The centre brings together researchers, clinicians and allied health professionals with an interest in nutrition during pregnancy and infancy. Its team of investigators includes basic scientists, dieticians, immunologists, and research clinicians. Research areas include pregnancy and infant nutrition, studies of consumer behaviour, and nutritional metabolomics. The centre focuses on the application of translational research to improve health outcomes for Aboriginal and Torres Strait Islander peoples, with particular focus on the prevention, treatment and management of chronic diseases. Its a collaborative enterprise between the National Aboriginal Community Controlled Health Organisation, the Wardliparingga Aboriginal Research Unit, SAHMRI and the University of Adelaide. Centre of Clinical Research Excellence for Oral Health (partner) The centre conducts research to improve primary oral health care for disadvantaged Australians, comprising four major themes: >successful ageing and oral health >rural oral health >Indigenous oral health >the oral health of people with physical and intellectual disabilities. Cooperative Research Centres The University is also a core partner, supporting participant or associate in 11 Cooperative Research Centres (a Commonwealth Government program linking industry with government and higher education research organisations): >CRC for Greenhouse Gas Technologies >Pork CRC >Deep Exploration Technologies CRC >Energy Pipelines CRC >CRC for National Plant Biosecurity >Poultry CRC >Bushfire and Natural Hazards CRC >Data to Decisions CRC >Invasive Animals CRC >CRC for Water Sensitive Cities >Sheep CRC Research Impact 15 Fellowships and awards The University benefits considerably from externally funded research fellowships, at various academic levels and across disciplines. The following provide a small number of examples. Professor Ian Reid, School of Computer Science, ARC Australian Laureate Fellow Professor Reid’s fellowship project is creating a computer vision system that can produce a detailed environmental map in real time, turning standard video cameras into sensors that ‘understand’ a scene with basic semantic tools. This high-level sensing is intended to unlock a wide range of applications for autonomous systems, in areas such as cognitive robotics and surveillance. The outcome will be a system that uses machine learning for continuous performance improvement. Professor Reid is an expert in the field of computer vision; an active field of information engineering that intersects with computer graphics, machine learning, artificial intelligence and robotic control. 16 Research Impact Dr Tanya Zivkovic, School of Social Sciences, ARC Discovery Early Career Researcher Award Given Australia’s diverse ageing population, there is increasingly urgent need for culturally sensitive end-of-life care. Currently, end-oflife planning is promoted and standardised in the form of advance care directives, which have a lower uptake in culturally and linguistically diverse groups. Dr Zivkovic’s project aims to identify and theorise points of uptake and resistance to advance care planning in Australia’s largest Asian populations. This new knowledge will be used to develop strategies for cross-cultural understanding in relation to end-of-life care preferences. The outcomes will have a strong bearing on how community attitudes, the experience of individuals, professional protocols and legislation evolve in Australia. Working in the area of social and cultural anthropology, Dr Zivkovic has considerable experience in ethnographic, gender and health research. Professor Ben Mol, School of Paediatrics and Reproductive Health, NHMRC Practitioner Fellowship An obstetrician gynaecologist and clinical epidemiologist, Professor Mol led a nationwide research collaboration in the Netherlands on comparative effectiveness research in reproductive health before moving to the University of Adelaide. He is now using his fellowship to modernise the knowledge base for reproductive health care, and establish the use of individual patient data meta-analysis as the new standard for evidence synthesis in reproductive health. This will lead to more personalised medicine in this area, with a global collaboration between reproductive health practitioners and researchers. Using individual patient data of cohort studies and randomised clinical trials, the study will develop clinical rules and guidelines that tailor the individual profile of the patient at the level of the homogeneous sub-group, facilitating optimal translation of trial results to clinical practice. Dr Elizabeth Hoon, School of Public Health, Arthritis SA Florey Research Fellow A key focus of the fellowship’s research program is on empowering people to manage their musculoskeletal conditions. This is being done through the examination of barriers to participation in communitybased musculoskeletal preventative programs and services, with a view to improving access and participation for all. This fellowship is providing an opportunity for a university researcher to partner with a community-focused organisation that is gaining significance in the management of a highly prevalent group of chronic conditions. Dr Hoon’s background and work experience in sociology and geography informs her interest in how health service research connects with wider social theories and research methodologies to understand the material, social and psychological processes underpinning patient outcomes. Research Impact 17 Research impact 18 Research Impact Research Impact 19 Ultimately our research will provide our industry with an integrated strategy to meet this challenge, and anything else that comes their way, with absolute confidence. 20 Research Impact Vintage innovation Helping our wine industry modulate flavour and alcohol levels in the face of climate and market change Ironically, for a product synonymous with relaxation and refinement, wine has always required considerable sweat and tears to produce. Both in the vineyard and the winery, the hours are long and the work hard; and no matter how diligently producers apply themselves they remain at the mercy of two notoriously fickle masters – climate and consumer taste. “We’ve used different picking times, yeast strains, fermentation, filtration methods, winemaking supplements, and so on,” said Professor Jiranek. What’s long been needed is a scientific, evidence-based approach with which to nimbly navigate this shifting ground and provide greater likelihood of return on the many months of toil. According to Professor Jiranek, the ability to create lower-alcohol wines without compromising flavour quality is becoming critical for Australian producers, as it is for producers elsewhere in the world. Today, through the University of Adelaide’s ARC Training Centre for Innovative Wine Production (TC-IWP), that goal is on the brink of being achieved, which promises to deliver a significant international advantage for our local wine industry. “Alcohol content in local wines has been creeping up over the past few years. The average for reds is now around 14 per cent, with some extremes exceeding 17. Research has shown, however, that there’s strong consumer interest in low-alcohol wines for health reasons, both at home and abroad, but mainly as consumers try to manage alcohol consumption responsibly around work and driving. There are also greater tax and duty impositions on wine of higher alcohol content when imported in key markets overseas.” “Australian wine producers are facing major challenges through climate change, water restrictions, changing consumer preferences and rising wine alcohol content,” said TC-IWP Director Professor Vladimir Jiranek. “So our number one objective is to give them the ability to confidently adapt their methods as conditions change, and reliably produce specific flavour profiles and alcohol contents for specific markets. “Having this year completed our first vintage, we’re well on our way.” Funded by the Australian Research Council (ARC) with additional financial support from the Australian Grape and Wine Authority, the centre’s researchers have made over 100 wines of various varieties, using grapes sourced from a number of South Australian and New South Wales vineyards. Each has been made using a different combination of flavour and alcohol modulation techniques, to provide detailed evidence of their effects relative to conditions. “Final alcohol contents range from 8 to 18 per cent, and we’re now conducting comprehensive chemical analyses. That will be followed by detailed sensory evaluations and wine consumer trials.” “Ultimately our research will provide our industry with an integrated strategy to meet this challenge, and anything else that comes their way, with absolute confidence.” Established in 2013, the TC-IWP hosts 14 postgraduate students and four postdoctoral fellows working across 13 research projects. The centre is also supported by Charles Sturt University, the Australian Wine Research Institute, CSIRO, SA Research and Development Institute, BioInnovation SA, NSW Department of Primary Industries, Treasury Wine Estates, Laffort Oenologie Australia, Lowe Wines, Memstar, Tarac Technologies and Sainsbury’s Supermarkets. Research Impact 21 What’s an acceptable balance between the protection of public security and personal privacy? 22 Research Impact Returning the gaze Raising awareness and informing debate on the growing threat of digital surveillance, ‘big data’ and identity profiling For billions of people around the world, digital technology is their friend. Almost globally, we’ve embraced its high-definition, 24/7 convenience and on-tap social connection with open arms. We regularly invite and digest a constant stream of personally targeted information. Similarly, we draw great comfort from the prevention or punishment of criminal activity as a result of online intelligence gathering or CCTV footage, and the use of digital data to enable improved health care. and legal control surrounding who had access to our information, and how businesses and government could use it to make assumptions about our personality and behaviour. There is, however, a worrying flipside: a genuine and growing threat to our privacy and perceived identity. Recent research at the University of Adelaide has found that, not only is this far more dangerous than many realise, but our laws are woefully inadequate to protect us. Importantly, Dr Humphreys said “opting out” of the digital world was not an option, as it excluded people from their networks and did not address the underlying problem. The only appropriate response, the research found, was for the management of our digital information to be brought under the rule of law. Co-authored by Professor Melissa de Zwart of the Adelaide Law School and Senior Lecturer in Media Dr Sal Humphreys, the research looks at the impact that digital data capture and consumer or citizen profiling could have on our lives, and the capacity of current US, UK and Australian laws to mitigate the risk of harm. On both counts, the findings have raised grave and – considering the Australian Government’s ongoing deliberations regarding data capture for anti-terrorism purposes – timely concerns. “Ideally, all forms of surveillance would be ultimately accountable to a selfgoverning public.” “Our every ‘post’, online purchase and GPS-tracked journey is captured and stored,” said Dr Humphreys. “Data can even be harvested from our smart phones through Bluetooth and Wi-Fi while we’re walking through public spaces.” The biggest danger of this, according to Dr Humphreys, was a lack of transparency “Algorithms are used to categorise us according to our choices,” she said. “However, these data profiles aren’t a true representation of us, because they lack context – algorithms never ask why we do what we do. That can be a big problem when we apply for credit or when police identify people of interest.” Dr Humphreys believed debate and change were urgently needed to address these issues, before it became impossible for citizens to preserve any semblance of online privacy. “What’s an acceptable balance between the protection of public security and personal privacy? Who will advocate for that balance if governments are seen to have a vested interest in saturation surveillance? “We’re hopeful our research will inform these conversations, establish frameworks with which to make sense of the issues and, ultimately, contribute to the creation of policies that serve the interests of a free and open society.” Research Impact 23 We can’t wait to see the benefits of this technique filter through into the development of more energy efficient industrial processes. 24 Research Impact Pedal to the metal Enhancing industrial chemical production with the world’s first porous nanomaterial for analysing catalytic reactions Many people would consider “catalysis” to be, at best, little more than a vague and distant memory; a topic not touched on since high school science classes. Yet, despite its infrequent use in dinner-party conversations, we all benefit from it daily. Virtually every industrial chemical on the planet is produced using some form of metal-based catalytic reaction, and these chemicals are integral in a vast array of our products and processes. These include plastics, rubber, textiles and clothing, agriculture, paper production, petroleum refining and manufacturing. So when researchers from the University of Adelaide’s Centre for Advanced Nanomaterials recently succeeded in creating a more efficient and accurate way to analyse these vital reactions, it was big news. “Ultimately our work is going to facilitate the development of new, or more effective, catalysts that are tailored to deliver specific chemical products,” said lead researcher Associate Professor Chris Sumby. “It’s of fundamental importance to the scientific community.” Fittingly, the research team’s breakthrough, published in the journal Nature Chemistry, builds on the Nobel Prize-winning work of University of Adelaide alumni Sir William and Sir Lawrence Bragg. In 1914 the remarkable father-and-son team pioneered the use of X-rays to determine crystal structure, providing valuable insight into the relationship between atomic structure and material function. The Braggs’ technique – known as X-ray crystallography – relied on the sample being crystalline so as to provide an observable long-range atomic order. However, according to Associate Professor Sumby, his team has developed a new nanomaterial to house samples that eliminates the need for them to be crystallised. “It’s a porous metal-organic framework [MOF] with a sponge-like structure,” said co-investigator, Associate Professor Cristian Doonan. “This enables us to simply ‘pour’ metal samples in, together with chemical reactants, and achieve the necessary long-range order immediately. “We can then conduct the reaction and examine the structures of the products using X-rays without having to isolate them or grow crystals. We can potentially even capture ‘snapshots’ of the structures while the reactions are still happening, which certainly can’t be done normally with X-ray crystallography. “We can’t wait to see the benefits of this technique filter through into the development of more energy efficient industrial processes.” The ongoing MOF research is jointly supported by the Science and Industry Endowment Fund and the Australian Research Council. Research Impact 25 30 to 50 per cent of stillbirths are unexplained, and health care workers are often poorly trained to provide an adequate level of care. 26 Research Impact A softer place to land Showing the way for improved quality of care for parents of stillborn babies Australia-wide Stillbirth is one of our society’s hidden nightmares. Though rarely discussed, even by health practitioners with parents-to-be, it is experienced by one in every 135 Australian families. Twice as many lives are lost to it each year as are taken in road fatalities, and 30 times more than by Sudden Infant Death Syndrome. Not surprisingly, the experience is devastating for those affected. Besides having to cope with the inevitable grief, parents are also at heightened risk of depression and self-blame; a dangerous spiral that can be exacerbated by the fact that 30 to 50 per cent of stillbirths are unexplained, and health care workers are often poorly trained to provide an adequate level of care. On this latter front, however, progress is now being made Australia-wide as a result of research conducted recently by the University of Adelaide’s Joanna Briggs Institute. In a project funded by the Stillbirth Foundation Australia, researchers at the institute first conducted a worldwide review of studies into how families experience care after stillbirth, and then produced a series of best-practice guidelines for health practitioners. These guidelines are now freely available on the Stillbirth Foundation Australia website and have been embraced by health professionals and relevant industry bodies across the country. “Quality of care is one area where we can make a huge and positive difference for families coping with stillbirth,” said Associate Professor Zoe Jordan, Director of Communication Science at the institute. “Our research confirmed that the actions, behavior and communications of health care professionals during their interaction with parents, and the stillborn baby, can have a considerable impact on parents’ psychological well-being.” According to Associate Professor Jordan, the research findings show that parents are most comforted by health care professionals who are prepared to involve them collaboratively in decision-making, and who provide empathetic, sensitive, culturally appropriate and respectful care at all times. “In our guidelines we identify three key stages in the care process – from diagnosis to birth, immediately after birth, and post-birth onwards. Each stage is critical and may require unique information and support provision. “For example, this can include guidance around such difficult issues as: what to expect from the delivery; how to arrange the induction and birth environment; whether or not to conduct an autopsy; holding, bathing and spending time with the baby, and so on.” The research team is hopeful that the care guidelines will soon be rolled out nationally in a rigorous implementation plan to ensure comprehensive uptake of the guidance in clinical settings. “We’re also advocating for its incorporation in an education program,” said Associate Professor Jordan. “Our research confirms that health care professionals themselves can be emotionally affected by stillbirth, which can influence their interaction with parents. So it’s something they really need to prepare for.” Research Impact 27 We’ve now conducted hundreds of successful flights and trained dozens of conservation workers across many countries ... 28 Research Impact Passing the remote Giving developing countries the power to protect their threatened tropical ecosystems through unique “conservation drones” Wildlife and environmental conservation is a challenge wherever it occurs, but particularly so in tropical developing countries. With rapid deforestation, poaching and the spread of agriculture and industry, the need is high. Yet funds are scarce, distances vast and terrain often difficult, if not impossible to negotiate by foot or car. Research by University of Adelaide Associate Professor Lian Pin Koh, however, may provide a solution. For the past few years, Associate Professor Koh, of the University’s Environment Institute, has been investigating the development and use of low-cost unmanned aerial vehicles (UAVs), or “drones”, for conservation-related applications. His work has not only proven the idea viable but, through his not-for-profit organisation ConservationDrones.org, is already making a significant difference to the effectiveness of conservation efforts worldwide. “The idea first came to me in 2011,” said Associate Professor Koh. “I was discussing the challenges of wildlife conservation in Southeast Asia with a colleague, Serge Wich [Liverpool John Moores University], and we wondered if UAVs might be an option. “We quickly discovered most commerciallyavailable UAVs were too expensive for conservation groups in developing countries, though. So we decided to develop our own low-cost drone specifically for the task.” Their first prototype – remarkably produced for less than AUD$2,000 – was tested in February 2012. Over four days in North Sumatra, it collected thousands of high quality images of forests and wildlife. Word spread, and they were soon overwhelmed with interest from peers and press. They co-founded ConservationDrones.org just two months later and have since expanded it into a worldwide initiative. “We’ve now conducted hundreds of successful flights and trained dozens of conservation workers [in the use of UAVs] across many countries, including Indonesia, Malaysia, India, Congo, Madagascar and more. “Our machines can be fitted with all sorts of camera systems, including thermal imaging. We can even use the images to produce three-dimensional models of the terrain.” Associate Professor Koh said a particularly valuable feature of the drones was that they could be programmed to fly very close to forest canopies. This had enabled researchers to detect elusive orangutans, elephants, rhinoceros, forest buffalo and turtle nests. “All photos are also tagged with GPS coordinates,” he explained, “which has given authorities the ability to prosecute illegal loggers, and spot poachers’ distant campfires.” A key research focus for Associate Professor Koh was to expand the impact of this technology. “I’ve recently established an Unmanned Research Aircraft Facility here at the University. This provides a ‘coalescing node’ for information exchange among environmental scientists, natural resource managers, and conservation practitioners in South Australia. “One of the first projects I will be involved with in Australia through the facility is the development of a drone to radio-track Australian wildlife, such as wombats, wallabies and bilbies. This will help identify where species are located, their habitats and how to protect them against threats.” Research Impact 29 ... the study was recently awarded an $8m grant from US-based charity The Helmsley Charitable Trust, in partnership with JDRF Australia’s Type 1 Diabetes Clinical Research Network. 30 Research Impact Zeroing in on type 1 Identifying the likely environmental triggers behind the rapid rise of childhood-onset type 1 diabetes Type 1 diabetes has been described as an invisible disease. Those untouched by type 1 diabetes rarely see or understand the 24-hour a day balancing act that goes on behind the scenes. A person living with type 1 diabetes must constantly monitor their intake of carbohydrates, insulin, exercise, stress and a multitude of other factors that affect blood glucose levels. It’s a constant burden that, so far, cannot be removed and the consequences of having blood glucose levels that are too low or too high can be dire. Even more worryingly, over the past 20 years the rate of childhood-onset type 1 diabetes in Australia and around the world has doubled. Recently, some good news has emerged. A team led by the University of Adelaide’s Robinson Research Institute and the Women’s and Children’s Hospital is conducting a landmark Australia-wide study that it hopes will reveal the disease’s pre- and postbirth environmental triggers, and inform its prevention and cure. Called the Environmental Determinants of Islet Autoimmunity (ENDIA) study, it’s the largest of its kind in the world to include early pregnancy observations in the natural history of type 1 diabetes. “We believe the modern environment that the child is exposed to in early life holds the key to understanding the increase in type 1 diabetes,” said lead researcher Professor Jenny Couper. “Factors such as nutrition, weight gain, chronic inflammation, viral infections and the bacteria colonisation of our bodies (the microbiome) may drive or protect against the development of type 1 diabetes. Importantly, children are exposed to these factors inutero, which is where the origins of type 1 diabetes may lie. This seems likely as the first detectable sign of diabetes developing is commonly in the first year of life, long before the disease presents clinically. Our research aims to identify the early life exposures that lead to type 1 diabetes and the genes that are involved.” The potential of the ENDIA study to accelerate the global understanding of type 1 diabetes has been recognised internationally and the study was recently awarded an $8m grant from US-based charity The Helmsley Charitable Trust, in partnership with JDRF Australia’s Type 1 Diabetes Clinical Research Network. Professor Couper and her team are following the development of 1,400 children in great detail across Australia from pregnancy to early childhood. All participants have a first-degree relative with type 1 diabetes. “There are many reasons why the environment has firmed as a suspect in the rise of type 1 diabetes,” said Professor Couper. “For example, the proportion of sufferers who have ‘high risk’ genes is actually decreasing and the increase in incidence is accounted for by people with ‘medium risk’ genes”. “We’re hopeful that identifying the environmental factors that increase or decrease risk could lead to effective new prevention strategies.” In addition to the recent funding boost, the ENDIA study is also supported through a Centre for Research Excellence based at the University of Adelaide with $2.5 million in funds from the National Health and Medical Research Council and JDRF Australia. Other contributing institutions are the Walter and Eliza Hall Institute, Royal Melbourne Hospital, University of New South Wales, University of Sydney, University of Western Australia and University of Queensland. Research Impact 31 We’ve now set up the framework for the development of a vibrant new relationship that promises significant benefits for the communities of China and Australia, 32 Research Impact An ally emerges in the east Partnering with Shanghai Jiao Tong University to enhance the agriculture and health of Australia and China As the world’s most populous nation and second largest economy, China is undoubtedly a key player in all world affairs, and the importance of Australia’s political and economic relationship with the Asian power is well documented. Less often considered, though also of enormous value, are our educational and research ties. have mutual research interests and complementary capabilities.” The University of Adelaide was delighted to play a part in strengthening these ties recently, by entering into a formal partnership with Shanghai Jiao Tong University, one of China’s oldest and most prestigious universities, with the agreed objective of seeking to improve the agriculture and health of both countries. A significant figure in the development of this relationship has been Professor Dabing Zhang, an international authority in plant science who divides his time between Shanghai Jiao Tong and Adelaide’s highly regarded Waite campus. Professor Zhang was appointed to the joint professorial position in 2014, in recognition of his tireless efforts to strengthen the universities’ engagement. “We’ve now set the framework for the development of a vibrant new relationship that promises significant benefits for the communities of China and Australia,” said University of Adelaide Deputy Vice-Chancellor and Vice-President (Research), Professor Mike Brooks. The universities have begun working together on joint research programs in four major areas: agriculture and wine, land and water, food safety and quality, and health and nutrition. Each program will also include the development of new technologies and their commercialisation, in turn creating further trade opportunities. According to Professor Brooks, the two institutions are ideal partners for such initiatives. “Shanghai Jiao Tong is a member of the distinguished C9 League of researchintensive Chinese universities – an equivalent of Australia’s Group of Eight, to which Adelaide belongs,” he said. “We also The universities are also collaborating within teaching programs, postgraduate training, infrastructure development and academic staff exchange, and are establishing a new joint research centre based in Adelaide and Shanghai. “It was Professor Zhang who first championed the creation of a joint master’s degree between Shanghai Jiao Tong and Adelaide,” said Professor Brooks. “It’s also in large part due to him that our relationship has progressed so effectively in a relatively short period of time. We’re honoured to have him with us.” Professor Zhang’s personal research focus is into the key issues surrounding food security, including the generation of more environmentally resilient and productive crops. “We’re hopeful of attracting additional funding for this and other joint ‘smart agriculture’ research,” said Professor Brooks. “After all, producing sufficient safe and nutritious food is fundamental to ensuring a healthy population, clean environment and strong economy for both countries.” Research Impact 33 ... analysis of this information ... will provide our wine producers with invaluable market insights. 34 Research Impact Decanting greater market intelligence Informing our wine industry’s growth strategies through a world-first database of global wine grape production If the first step in identifying how to proceed commercially is to know where you stand relative to your competitors, researchers at the University of Adelaide have provided the Australian wine industry with arguably the most important “GPS” it’s ever had. With funding from the former Grape and Wine Research and Development Corporation (now part of the Australian Grape and Wine Authority), the University’s Wine Economics Research Centre has created the world’s first database to comprehensively map the bearing area of every wine grape variety in every wine region around the globe. Importantly, the data also shows changes over time. Led by School of Economics Professor Kym Anderson, researchers gathered in-depth information from the years 2000 and 2010 on more than 1,500 unique wine grape varieties across 48 countries. Further data was also captured for the major wine grapegrowing nations from earlier decades, and a particularly detailed supplementary database has been created for Australia. According to Professor Anderson, analysis of this information – which he and a colleague have published in an award-winning book – will provide our wine producers with invaluable market insights. “There’s a huge range of big-picture intelligence to be gleaned,” he said. “For example, we can see definitively how the mix of grapes differs from one Australian region to another, and between those Australian regions and regions of other countries. We can also see what percentage of a region’s production is accounted for by each variety and how that’s changing.” Professor Anderson said the data had shown Australia’s varietal range was far narrower than in many other countries, and that range is continuing to decline. This situation was also reflected between our regions, which indicated a need and opportunity for greater diversification. “Here in Australia, our top three varieties make up 64 per cent of our vineyards, and the top 10 accounts for 88 per cent. Whereas in Italy, for example, those figures are just 23 per cent and 45 per cent respectively.” Another valuable insight that could be drawn from the data is which varieties are performing well in regions that our own are likely to resemble climatically in future. “Wine producers are well aware of the impact climate change is having. They’re continually on the lookout for attractive varieties that perform well in climates similar to what they expect to experience in decades ahead.” The next phase for the project would involve international researchers preparing complementary in-depth analyses for their own countries’ wine industries. This process is already underway, said Professor Anderson, in many cases with his collaboration. For more information The global wine grape database is freely available online at: www.adelaide.edu.au/ wine-econ/databases/winegrapes Professor Anderson’s book analysing the data, Which wine grapes are grown where? A global empirical picture, produced with the assistance of statistician Nanda Aryal, is also available to freely download at: www.adelaide.edu.au/press/titles/ winegrapes The book was joint winner in 2014 of the prestigious International Organisation of Vine and Wine Prize for the best viticulture books published globally. Research Impact 35 Our researchers 36 Research Impact Dr Michael Sheng Web Technologies Since its birth in the early 1990s, the World Wide Web has changed our world and society quickly and profoundly, by sharing knowledge and connecting people. Very recently, the Web has begun to connect ordinary things in the physical world, moving towards a so-called Web of Things (WoT). WoT is widely regarded as the ultimate goal of the World Wide Web and offers exciting capabilities to change the world and improve the quality of human lives in the coming decade. Advancing the Web technologies – and particularly WoT is the main research focus for Associate Professor Michael Sheng, Deputy Head of the School of Computer Science at the University of Adelaide. Michael has recently been awarded a prestigious ARC Future Fellowship (2014-2018), with total funding of $757,452. His ARC Future Fellowship project focuses on the most fundamental research question of WoT: how to efficiently and effectively manage billions of things over the future World Wide Web. Michael is investigating this key problem and developing novel techniques for linking resourceconstrained things to the Web, searching them using a new search engine, as well as discovering latent relationships among things for advanced management tasks, such as things recommendation and composition. Michael is also currently leading two ARC Discovery Projects. One project focuses on understanding human activities using low-cost, unobtrusive radio-frequency identification (RFID) and sensor technologies, which holds the potential to help the ageing population live better. The other project focuses on truth discovery from diverse, noisy, and large data sources available on the Web. In 2012, Michael won the Chris Wallace Award for outstanding research contribution, which is the most prestigious award in computer science, given to only one person each year in Australia and New Zealand. His research has attracted more than $2.6M and he has published more than 200 papers in world-leading journals and conferences. Michael’s research has been highly cited by his international peers and he is listed as one of the “Top Most Cited Authors” in the World Wide Web research area (ranked 133 out of 49,350 authors, top 0.26%) by Microsoft Academic Search. Research Impact 37 Dr Giang Nguyen Civil Engineering There are many cases around the world where catastrophic failure and collapse at underground mine sites or geotechnical infrastructure has resulted in huge loss of life and property. Dr Giang Nguyen, from the School of Civil, Environmental and Mining Engineering, is seeking to better predict this type of collapse by understanding the way materials behave under various environmental and load conditions. Funded by an Australian Research Council (ARC) Future Fellowship, Giang is developing a modelling framework to better scale material properties from laboratory samples to field structures. 38 Research Impact “It’s very hard to predict the effect of a natural disaster or failure in infrastructure,” Giang says. “All we can do as engineers to ensure optimal stability is to do laboratory tests on small specimens taken from the site and use this analysis to project what might happen on a larger scale. “But there are obviously different behaviours between small specimens of 10cm3 than for large structures of 100m3 or more.” Giang’s new methodology aims to properly link failures at the microscale, specimen scale and large (field) scale in order to develop inexpensive numerical tools. These could help engineers when building large structures, such as dams, rock slopes, embankments and mines, to ensure cost-effective designs and greater confidence in safety. Giang has been conducting research in this area for over 14 years, since the start of his PhD in Oxford. He joined the University of Adelaide in July 2013, after spending six years at the University of Sydney. “The School of Civil Environmental and Mining Engineering is an excellent environment for multidisciplinary research. I have been given strong support and had opportunities to interact and collaborate with academics across several disciplines, such as Geotechnical & Structural Engineering, Mining Engineering, and Mechanical Engineering. “This is stimulating and also helped me win the prestigious Future Fellowship from the Australian Research Council.” Dr Damien Fordham Global Change Biology Global extinction rates have soared over the past century, due predominantly to the resource demands of a burgeoning human population. Shifting land use, wildlife exploitation, and elevated rates of competition and predation by invasive organisms have reduced the ranges and abundances of many species. Dr Damien Fordham, an ARC Future Fellow working in the University’s Environment Institute and School of Biological Science, conducts research focused on the causes and consequences of extinction. His approach is innovative in that it marries quantitative ecology, evolutionary biology, climatology and palaeontology in forecasts of species’ distributional range changes, extinction risks and climate change impacts. Damien’s particular area of expertise is the development of models that integrate demographic, physiological and evolutionary processes to better anticipate the likelihood of at-risk species and communities being eliminated. These predictive tools can then be used to better design and implement effective conservation strategies. Researchers across the globe are now adopting the conservation modelling approaches and tools that Damien has developed. For example, his modelling of the combined effects of climate change, prey availability and management intervention is being used to develop conservation strategies for the Iberian lynx in Spain and Portugal. As one of Europe’s last top mammalian predators, this species constitutes the world’s most threatened cat, and the European Union has spent more money on it (€94 million since 1994, and €31 million since 2002) than any other European species of conservation concern. “Through my interactions with world-class academics at the University,” he says, “I have been able to develop a wide network of international and national collaborators in research areas ranging from conservation and evolutionary biology to climate science and paleoecology. “The establishment of this network has helped provide me with the multi-disciplinary skill set needed to generate world-leading research on the ecological consequences of global change.” Research Impact 39 Dr Simon Baxter Evolutionary Biology Controlling unwanted pests that can devastate crops, such as leaffeeding insects, has always been a major challenge in farming. Today, farmers have an arsenal of insecticides to help minimise damage to crops. However, pests can develop resistance, and particularly when the same insecticide is used repeatedly. Doctor Simon Baxter’s research focuses on identifying genetic mutations that cause insecticide resistance, to help understand how these products kill pests and how they can be better utilised. Working in the University of Adelaide’s School of Biological Sciences, with funding from the Australian Research Council and a Ramsay Fellowship, Simon’s current work focuses on Bacillus thuringiensis (Bt) bacteria, which can produce hundreds of different types of toxins that each kills specific groups of insects. The 40 Research Impact genes that encode Bt toxins are now used in some transgenic crops, such as cotton. he took on a part-time research job investigating how Drosophila fruit flies adapt to different climates. While transgenic crops remain a highly controversial topic in politics and society, and can be problematic for organic farmers, their use could help to maximise crop yield and minimise crop losses due to insect damage in the future. “As my interest in insect adaptation grew, I began to focus on science with strong links with industry,” says Simon. “Around the same time, transgenic crops expressing Bt toxins were commercially released and I became interested in how insects could potentially adapt and evolve resistance to these toxins.” The ultimate goal of the research relates to food security. With the world’s population predicted to reach nine billion by 2050, we will need to produce more food globally to sustain demand – hopefully at minimal cost to our environment. While they won’t be the sole answer to world hunger or human sustainability, transgenic crops are likely to form part of an integrated pest management solution. Understanding the specific mechanisms Bt toxins use to kill targeted pests may help society decide whether to adopt this technology further. Simon’s interest in this area was first piqued in his undergraduate years at Monash University when Simon decided to undertake a PhD at the University of Melbourne, focusing on molecular mechanisms of insecticide resistance in agricultural pests, before moving to the UK to study insect adaptation and evolution. He then joined the University of Adelaide in 2012. “During my time at the University of Adelaide, I have established multiple new collaborations with scientists in China and the US. Adelaide is a national hub for agricultural research, which provides a supportive environment to undertake my work.” Professor Deb White Leukaemia Research Professor Deborah White is Deputy Cancer Theme Leader and Director of Cancer Research at the South Australian Health and Medical Research Institute (SAHMRI). She is an Affiliate Professor in both Medicine and Paediatrics at the University of Adelaide. In this role, Deb has established the Cancer Theme, bringing together outstanding leukaemia and stem cell researchers. Deb is responsible for the conduct of approximately 100 cancer researchers, and is also directly responsible for her research group of over 20 researchers and postgraduate students. Deb’s current research projects focus on the treatment of patients with chronic myeloid leukaemia (CML) and acute lymphoblastic leukaemia (ALL). Despite the remarkable clinical success of tyrosine kinase inhibitors (TKIs) to treat patients with CML, not all respond optimally. Deb and her team are working to address the key factors that dictate response to TKI therapy.“In CML we are on a ‘path to cure’,” says Deb. “Our ultimate aim is treating patients in such a way that they will remain disease-free off of therapy.” Deb has a growing national and international reputation in ALL. She is working to ensure that: there is an understanding of the disease drivers in high-risk ALL; each patient receives the right therapy for their disease; relapses are averted; and those who do relapse can be successfully treated. “My overarching goal and that of my group is to ensure we use the best therapy, at the best time, to ensure the best result for each leukaemia patient,” she says. “The drugs and tools we have available mean that we can indeed ‘personalise’ approaches for each patient.” Deb commenced her career in Haematology at IMVS (now SA Pathology), before completing a PhD at the University of Adelaide in 2007. As part of her PhD, Deb developed in vitro and in vivo assays to assess the efficacy of TKIs in CML cells (intrinsic sensitivity) collected at the time of patient diagnosis, and during the first month of TKI therapy. These were the first bioassay to optimize kinase inhibitor therapy in any cancer, and remain in use today in all CML clinical trials in Australia and elsewhere. Deb’s PhD also focused on defining biomarkers to predict which patients would do less well than others. “I was keen to make a difference and wanted my research to be directly related to patients.” Deb became a Fellow of the Faculty of Science of the Royal College of Pathologists within three years of completing her PhD and a Professor in the University’s School of Medicine within five. She has authored over 65 papers, presented more than 150 national and international peer-reviewed talks, and in 2014 received the Australian Society for Medical Research (ASMR) SA Leading Light Award. Research Impact 41 Assoc. Prof. Jeremy Thompson Reproduction - oocyte and early embryo development Jeremy Thompson’s research has two main goals: >> enabling infertile couples to achieve a healthy pregnancy and a healthy baby following treatment >> maximising the reproductive potential of livestock species to provide farmers with better quality and ethical livestock production systems that makes economic sense. Although seemingly diverse, both objectives hinge on the production of healthy embryos. “I am inspired by the feeling of awe when I look down a microscope at a living early embryo,” Jeremy says. “Regardless of species, there’s an appreciation that this is the beginning of a whole new life. I never get tired of watching early embryos grow – they are fascinating.” 42 Research Impact A NHMRC Senior Research Fellow, based in the University of Adelaide’s School of Paediatrics and Reproductive Health, Jeremy’s research is focused on discovering the determinants of developmental potential within mammalian oocytes (eggs) and early embryos. Specifically, he investigates the metabolic regulation of oocyte and early embryo health and what maternal factors influence this. Along with collaborations on the roles of oocyte-secreted growth factors and reproductive tract cytokines, he is interested in how the mother’s metabolic health during the first few days of conception influences long-term health and development outcomes. Jeremy is Head of the Early Development Group at the University’s Robinson Research Institute and also holds the position of Biological Challenge Leader at the ARC Centre of Excellence for Nanoscale Biophotonics. As well as being the recipient of four current NHMRC grants, Jeremy is passionate about commercialisation of research and he partly funds his research team by commercial contracts. He has had a collaboration of over 20 years with medical device manufacturer Cook Medical, and he also generates his own research income through a University business unit, IVF Vet Solutions, which was initiated with a University Commercial Accelerator Scheme (CAS) grant. For more information on IVF Vet Solutions, visit: http://health.adelaide.edu. au/paediatrics-reproductive/ services-training/ivfvetsol/ Dr Anna Goldsworthy Creative practice: performance, music (piano and chamber music), creative writing Dr Anna Goldsworthy grew up in Adelaide and found her future career path from an early age, when she was accepted into the University of Adelaide’s Elder Conservatorium. “Meeting my teacher Eleonora Sivan when I was nine equipped me with a sense of musical vocation,” says Anna, “and my research activities have grown out of that.” Anna completed a Bachelor of Music (Honours) degree, before leaving Adelaide in 1996 for further study. In 2013, the University established the J.M. Coetzee Centre for Creative Practice and this provided Anna with a creative opportunity she couldn’t resist; she returned to Adelaide to take up a position as Research Fellow at the centre. Anna’s research takes the form of creative practice and she has multiple projects underway involving both her chosen disciplines, music and writing. These include: >> Jokes on Wheels, a coming-of- age novel set in Adelaide, funded with assistance from Arts SA. >> Seraphim Discovery Program, a multi-platform educational program introducing children and new audiences to classical music and chamber music. It incorporates a radio documentary, online 3D video exploration and children’s CD, alongside regional performances and schools residencies throughout South Australia. >> Beethoven Trios, a multi-faceted project researching performance practice in Beethoven’s piano trios, and forging pathways to community engagement in this repertoire, through: new-format immersive concert experiences; pop-up recitals; national concert series; interactive concert installations; collaboration with street artist Peter Drew; and radio documentaries. >> Beyond the Stage: interpreting history through performing arts practice, a project which aims to: create a definitive account of the impact of World War 1 on musical, operatic, and theatrical performances and their reception in South Australia during the period 1914-1920; interpret through performance the findings of the archival research; and design, apply and advocate by way of example a collaborative material history research methodology that is interdisciplinary in its approach and cross-media in its modes of dissemination. “The goal of my music-based research is to sustain and reanimate the classical/chamber music tradition, to ensure its survival and proliferation in the future.” Research Impact 43 Next generation researchers 44 Research Impact Kristin Carson Medicine: Indigenous Health and Tobacco Cessation Kristin Carson is proof that there are many pathways to a career in research. As a teenager, unsure of her future goals, she avoided science and came very close to failing Year 12. But a decision to obtain a TAFE Certificate III in Laboratory Skills changed her life and set her on the path to her career as a medical research scientist. After 9 years working in laboratories and hospital research institutions, Kristin was admitted to a Master of Medicine at the University of Adelaide, which she quickly upgraded to a PhD. Kristin’s thesis focuses on treatment options for tobacco cessation, prevention and related illnesses, with particular reference to Indigenous populations and Aboriginal and Torres Strait Islander (ATSI) Australians. “Closing the health gap between Indigenous and non-Indigenous Australians has been highlighted as a key national priority,” she says. “When considering that current tobacco use for Indigenous Australians is 2.5 times greater than use among the non-Indigenous population, research into reducing tobacco use has the potential to significantly diminish health inequalities.” Kristin is currently involved in over 40 research projects across different disciplines of medicine; all with a focus on translational health research. In 2015, she commenced a NHMRC Fellowship (co-funded by Cancer Australia). The first of its kind, it aims to train health professionals in smoking cessation, healthy lifestyle programs and how to translate evidence into practice for ATSI Australians. Through her studies, which she’s undertaking alongside employment at the Queen Elizabeth Hospital, Kristin has identified several barriers and enablers to smoking cessation, tobacco prevention programs and health service utilisation for ATSI Australians. These findings have subsequently been used to influence policy, practice and research across Australia. Her research has underpinned changes to the SA Health tobacco policy and evidence used by the Cochrane library to influence tobacco treatment on a global scale. Kristin’s research has resulted in over 50 peer-reviewed publications, more than 100 accepted conference abstracts, in excess of 300 media citations and multiple contributions to policy and practice locally, nationally and internationally. She has also been the recipient of several prestigious awards, including Young Australian of the Year for South Australia, The Premier’s and Channel 9’s Young Achiever of the Year and Young Citizen of the Year for the City of Holdfast Bay. Research Impact 45 Harsha Padmanabhan Gene therapy for Cystic Fibrosis Cystic fibrosis (CF) is the most common life-threatening recessive genetic condition affecting Australian children. While there is no cure, the faulty gene responsible for the condition has been identified as the CFTR gene, and research now focuses on how to repair or replace it. Harsha Padmanabhan’s research aims to contribute to this goal by developing an aerosol spray for delivering the lentiviral vector carrying the correct CFTR gene. Gene therapy involves inserting a working copy of the faulty gene. The concept is to use a viral vector (lentivirus) to carry the CFTR copy, and insert it into the CF patient’s lung. Harsha’s research is looking 46 Research Impact at developing this gene therapy into an aerosol spray, which will enable it to be delivered non-invasively. This would be an incredibly useful application, as we head towards clinical trials of gene therapy for CF in the future. “I’ve always wanted to do cutting edge research in the field of genetic medicine,” says Harsha. “The molecular concepts behind gene therapy and gene delivery are very interesting, and the fact that I could make a difference in someone’s life gives me the inspiration to pursue this research.” With a Bachelor of Science in Biotechnology from Manipal University in India and a Master of Human Biotechnology from Flinders University, Harsha joined the University of Adelaide as a research assistant for Bioconst Pty Ltd at the Waite campus, specialising in plant tissue culture. In late 2012, she joined the Adelaide Cystic Fibrosis Gene Therapy Research Group in the University’s Robinson Research Institute as a PhD student. Harsha is a recipient of the Women and Children’s Hospital MS McLeod Scholarship, Cystic Fibrosis Australia’s Top-Up Scholarship to help support her studies, and a European Molecular Biology Laboratory scholarship for a training course conducted in Melbourne. In 2014 she won the 3MT competition at the University of Adelaide and went on to represent the University at the Trans-Tasman Three Minute Thesis competition held in Perth. Chaolei Yuan Remediation of acid sulfate soils Chaolei Yuan has travelled over 7,000 kilometres to study Australian soil. A recipient of a China Scholarship – offered jointly by the University of Adelaide and the China Scholarship Council – he joined the University in 2012 with a Master of Science and passion for nature. His research focuses on acid sulphate soils, which are of great environmental concern here in Australia. Acid sulphate soils contain iron sulphides, and after disturbance these soils can be oxidised, releasing significant amounts of acid and toxic metals into surrounding soil and water. The resulting toxins have the potential to cause damage to our wildlife and waterways. Chaolei is researching ways to remediate these soils with the addition of organic matter. In his first three experiments, plant straw was mixed into the soil to increase soil pH by stimulating sulfate reduction after flooding. His current experiments extend this theme, using organic matter to prevent the oxidation or acidification of acid sulfate soils. understanding of how to manage acid sulfate soils. Chaolei is already having success in this area: as a result of his research, South Australia’s Environment Protection Authority is planning to conduct a field trial in Murray Bridge to remediate acid sulfate soils. His research was published in the ‘Journal of Environmental Management’ and presented in the 4th National Acid Sulfate Soil Conference. The ultimate goal of his PhD is to help land owners, natural resource managers and environment protection authorities gain a better Research Impact 47 Dr Deirdre Zander-Fox Infertility, Clinical In Vitro Fertilisation, Offspring Programming Deirdre Zander-Fox can trace her interest in infertility right back to her own conception. After 10 years of trying by her parents, Deirdre was conceived through IVF technology developed by the University of Adelaide’s Department of Obstetrics and Gynaecology. “I feel a strong link to this department,” she says, “as it has helped so many couples achieve their dream of having a baby - including my parents.” While studying a Bachelor of Science, Deirdre was again introduced to clinical IVF, via Dr Michelle Lane, a researcher at the University of Adelaide’s Robinson Research Institute. On hearing that one in six couples will need assistance to conceive, she was inspired to pursue this important area of research. 48 Research Impact At the completion of her degree, Deirdre began training as a clinical embryologist with Repromed, and – thanks to that organisation’s link with the discipline of Obstetrics and Gynaecology – was able to concurrently undertake her honours year. She then continued at Repromed while studying her PhD. “The ability to work in the clinical field gave me a unique insight into the clinical application of my research and assisted in making sure that my research was always of clinical importance.” Deirdre’s research currently focuses on improving clinical IVF laboratory technology that will directly benefit infertile patients. She is particularly interested in the impact of the environment during embryo development and how this can change embryo health and alter the health of the child. With two NHRMC grants, Deirdre is aiming to improve embryo freezing survival, as well as the screening of embryo culture media, to find the best embryo for transfer and thus improve pregnancy rates. Her ultimate goal is to improve the outcomes of in vitro fertilisation, making sure that the technology is safe and does not impact on the health of the child. “My research focuses not only on increasing pregnancy rates after assisted reproductive technology, but also on making sure that the children born from this technology are healthy for life.” Deirdre is now Scientific Director of Repromed and remains a Visiting Research Fellow at the University of Adelaide, where she performs research and supervises PhD and honours students. She is also a guest lecturer, providing students with insight into the latest techniques and challenges faced in the clinic. Dr Cristian Birzer Humanitarian Technology Dr Cristian Birzer’s research focuses on the development of humanitarian technologies for resource-constrained countries and regions. His motivation is to make complex engineering available and affordable to those who need it most, in order to help raise their quality of life, increase life expectancy, and reduce preventable deaths. of solid-fuel combustion in order to design new cookstoves with increased fuel-efficiency and reduced harmful emissions production. An early prototype cookstove design from the research group reduces carbon monoxide emissions by 90% when compared to traditional cooking procedures. The prototype, which can be made from scrap material at minimal cost, can also produce bio-char (a soil enhancer) as a by-product. Early in his research career, Cristian became aware of some key statistics: 3 billion people rely on solid-fuel (wood, dung, coal) burning stoves; and this results in 4 million people dying every year from respiratory-related illnesses. These facts led to the ‘cookstove project’. Other projects that Cristian and his research team (the Humanitarian Technology Research Group cofounded with Dr Paul Medwell and Dr Peter Kalt) have developed include water treatment, sanitation and power generation systems. This research can help save millions of lives every year and improve the quality of life for billions. Cristian’s cookstove research includes using state-of-the-art laboratories from the University’s Centre for Energy Technology to understand the complex nature Cristian aims to provide essential knowledge (open-source where possible) and designs that can be implemented to ensure those who cannot afford high-tech products can still have high-quality lives. He and his team also focus on ensuring the designs they develop can be made locally, so that communities can build and maintain their own products, thus strengthening their economies. “The ultimate goal of our research is to not be needed. We work with non-government organisations around the world to help implement the designs and products; we share the knowledge with anyone and everyone interested so they can implement the work; and we work towards building economies in regions where people earn less than $2 per day.” Cristian has received the following awards: >Tall Poppy Winner 2014 >Prince of Wales Award Winner SA 2014 >Young Professional Engineer of the Year SA 2012 >Young Mechanical Engineer of the Year (Australia) 2010. Research Impact 49 Alexander Robson Structural Geology Alexander Robson’s research involves analysis of the subsurface geology in the Ceduna Sub-Basin (Great Australian Bight), to understand how it evolved through geological time, forming its presentday geometry. Supported by funding from the Australian Research Council (ARC) and the Australian Society of Exploration Geophysicists (ASEG) Research Foundation, Alexander’s analysis involves interpretation and measurements of subsurface rock structures using a number of 50 Research Impact rigorous quantitative and qualitative techniques for determining kinematics (the bodies’ movement). Alexander obtained a Bachelor of Science (first class honours) at the University of Adelaide’s Australian School of Petroleum. Through his undergraduate study, he developed an understanding of the impact that this research could have on the Australian economy. Ultimately, his research has the potential to uncover oil and gas accumulations, which are steadily becoming harder to find. With the help of research such as Alexander’s, frontier Australian basins have a better chance of being identified for petroleum prospectivity, which may help uncover new Australian petroleum fields. For Alexander, it was an obvious choice to start exploring the Ceduna Sub-Basin, which has seen increasing interest from major oil and gas companies from around the world, including BP, Statoil, Chevron, Murphy Oil and Australia’s Santos. He is now also applying the same analysis to the Otway Basin in the deep-water province offshore from Portland, Victoria and the continental-shelf province offshore from Beachport, South Australia. Alexander is a big believer in the power of networking with fellow researchers and industry. “Keeping a close relationship with industry is vital in this type of research,” he says, “in order to generate new ideas and ultimately push future exploration in Australia’s frontier petroleum basins.” He is due to complete his PhD in 2016 and has already signed a contract with Australia’s largest energy company. Sarah Catalano Marine Parasitology and Molecular Evolution Sarah Catalano has always had a keen interest in conservation biology and the marine environment. highlighting the taxonomic confusion that surrounds this group, explored the unknowns in their life cycle, and used dicyemids as biological tags to assess host cephalopod population structure in southern Australian waters. She completed a Bachelor of Science (first class honours) in Marine Biology at the University of Adelaide, before going on to complete her PhD studies here in 2013. While Sarah’s PhD has added a wealth of knowledge to dicyemid faunal composition and ecology in Australian waters, many aspects of their life history and evolution remain unknown. Sarah is continuing on with research in this area, particularly focusing on uncovering the complete mitochondrial genome of dicyemids. Sarah’s PhD focused on dicyemid parasites, tiny marine organisms found in high numbers attached to the kidneys of benthic cephalopods (octopus, squid and cuttlefish). As part of this research, Sarah formally described 10 new dicyemid species from Australian waters and used molecular genetic techniques to characterise part of their mitochondrial genome. She presented a review article In addition, Sarah is now working as a Research Scientist at the South Australian Museum working on a joint ARC-funded linkage project (between the Australian National University, WA Museum & Herbarium, WA Department and Conservation, and SA Museum) investigating the biodiversity of amphibians and reptiles across the Pilbara and Kimberley regions in Western Australia. Both projects have a similar goal, which is focused on, and aligns with, one of our National Research Priorities – maintaining an environmentally sustainable Australia. “The main aim of my research is to manage and protect Australia’s terrestrial and marine biodiversity,” says Sarah. “I aim to achieve this using rigorous, thorough and comprehensive methods that are reproducible, ensuring conservation efforts and management plans are well informed to maintain our country’s biodiversity.” Research Impact 51 Collaborations 52 Research Impact Businesses are increasingly looking to the University of Adelaide to provide solutions to challenges and add value through new and improved products and services. The University has a long and proud history of productive partnerships with industry, government and the broader community. These partnerships move research to impact in the community and the economy. “Collaboration between publicly funded research organisations and industry is critical to knowledge diffusion and ensuring that our investment in research translates into innovation and productivity improvements that increase our national prosperity.” Business Council of Australia, Building Australia’s Comparative Advantages (2014) Adelaide Research & Innovation (ARI) is South Australia’s premier commercial research hub, facilitating access to the research and expertise of the University of Adelaide. It offers resources, support and funding to researchers, and provides a point of access for industry and government to engage and collaborate with academics on research, development and innovation. The ARI team have a wide base of skills and experience and are well equipped to match capabilities and opportunities to needs, handling thousands of interactions locally and internationally. These engagements create new products, services and improved policy, bringing a sharper competitive edge and broader community benefit. ARI also helps seedfund the next wave of technology innovation, and launch the new businesses of the future. Following are some examples of our success stories and the tangible outcomes that have resulted. These are only a few of hundreds of – largely unsung – examples of engagement between the University and its partners. Many others are featured in our publication, Adelaide Advancing (available at www.adelaideresearch.com. au). This includes 30 case studies of successful innovation, together with the stories of 10 ‘innovation champions’ - organisations that have been able to change their business (and sometimes the world) for the better, thanks to Adelaide researchers. Rob Chalmers Managing Director Adelaide Research & Innovation Pty Ltd Research Impact 53 Competition between fishing, mining and conservation can be difficult to manage, and presents real difficulties around Australia. 54 Research Impact Eco-management in the Spencer Gulf With competing priorities – from fishing to mining, agriculture, energy and community values – management of the Spencer Gulf ecosystem is akin to walking a tightrope between commercial and environmental interests. As South Australia’s growing mining sector, along with other industry development, leads to increased concerns regarding shipping, wharf facilities, and desalination of seawater in the Spencer Gulf, the region is under increased pressure to maintain its balance. These circumstances were the catalyst for the creation of the Spencer Gulf Ecosystem and Development Initiative. Led by the University of Adelaide’s Professor Bronwyn Gillanders and Simon Divecha, the initiative is driving responsible decision-making for a thriving gulf region. The University’s Environment Institute is central to developing the program, with Marine Innovation SA (MISA), SARDI (South Australian Research and Development Institute), Aquatic Sciences and Flinders University as research collaborators. The five-year project brings together key partners – including major players BHP Billiton, Santos, Flinders Ports, Arrium, Centrex and Alinta – and the fishing industry, which is investing through the Fisheries Research and Development Corporation. It is attracting major funding as researchers gather stakeholder views from more than 300 people, review available information, and scope requirements for research around an integrated ocean management program. Now in the midst of its second phase, the initiative’s research partners are undertaking significant investigations to establish an informed and evidence-based decisionmaking system regarding new developments, while maintaining ongoing stakeholder and community engagement. Competition between fishing, mining and conservation can be difficult to manage, and presents real difficulties around Australia. However, the creators of this initiative believe that this consultation process, alongside the evidence developed, will be the key to its success. The initiative will support industry by offering more defined approval pathways and encourage evidence-based decision making. It will also set up a model by which information, data, tools, capabilities and networks can be shared. The clever researchers, community and industries behind the Spencer Gulf Ecosystem and Development Initiative are playing a crucial role in ensuring the balance between commercial and environmental interests is maintained for everyone’s benefit. Research Impact 55 The innovative system will address the issue of microbiology labs needing to analyse more culture plates with fewer staff and resources, and often with more critical deadlines. 56 Research Impact Catching Disease Fast Up to 27,000 microbiology laboratories around the world could benefit from a ground-breaking automation technology developed at the University of Adelaide’s Australian Centre for Visual Technologies (ACVT), in collaboration with one of our leading medical technology companies, LBT Innovations. The Automated Plate Assessment System (APAS) can automatically screen microbiology culture plates for the presence of various disease-causing pathogens, revolutionising the workflow in modern microbiology labs. The smart software uses artificial intelligence to analyse microbial growth in much the same way as a microbiologist would, but with faster and more consistent results. Born from a pioneering partnership between the University and Adelaide-based LBT, APAS is in the final stages of development in a significant joint venture with the instrumentation company, Hettich AG Switzerland. It’s the perfect collaboration; LBT brings its extensive market knowledge and product development expertise, while Hettich provides some of the world’s finest medical engineering and manufacturing credentials. The deal also ensures that LBT Innovations will continue to play a leading role in the product’s future development and commercialisation. The company has already employed three Adelaide-based technical staff specifically to support its APAS program, as well as a Quality Assurance Manager to support clinical trials. APAS has its roots in a system that the University research centre developed for defence and security purposes, but the partnership with LBT unearthed its significant microbiology and healthcare potential. The core technology is currently being made commercially robust under contract with two Australian engineering companies, with the first APAS instruments due to be manufactured in Europe. The innovative system will address the issue of microbiology labs needing to analyse more culture plates with fewer staff and resources, and often with more critical deadlines. In May 2014, some of the world’s leading microbiologists were introduced to APAS at the European Congress of Clinical Microbiology and Infectious Diseases, an annual event that brings together more than 10,000 microbiologists, infectious disease specialists and diagnostic companies. The strategic focus of the Australian Centre for Visual Technologies is on impact, and there is no doubt that the clever minds behind APAS will soon be having a major impact on the world of microbiology. Research Impact 57 ... the relationship with Telstra, and this project in particular, has always been commercially focused, and as a result is a commercial success. 58 Research Impact A+ service for Telstra customers When most of us take out our mobile phones to make a call, check emails, browse the internet or download an app, we take it for granted that the mobile network will work. We can have this blind faith thanks to some very clever work being done by the University of Adelaide’s start-up company, TelAri, in partnership with Telstra. The outcome of the collaboration is a nifty ‘mobile network dimensioning tool’, which indicates the general health of the Telstra mobile network and ensures the corporation can make smart network investment decisions. Associate Professor Bruce Northcote, Director of the University’s Teletraffic Research Centre, said the tool allows the network operator – in this case Telstra – to make network predictions based on end-user experience, rather than simple network measurements. The project began some eight years ago – when Telstra began to roll out its 3G network – with a detailed analysis of Telstra’s network component vendor, Ericsson. From this, researchers were able to understand how Ericsson assigned resources to different types of uses, such as phone calls, web browsing and so on. They assessed hundreds and thousands of calls and the tool – known as ‘Devil’, as in ‘the devil is in the detail’ – is now able to use live data to drive network decision making. It provides accurate trend reporting, allowing Telstra to schedule upgrades before network capacity is reached, thus leading to greater customer satisfaction. The prototype took about nine months to develop. When Telstra brought in the 4G network, it took about two and a half years to complete the modelling for this new network. This shows how far mobile technology has come in that time, and the growth in its complexity. The partnership between Telstra and the Teletraffic Research Centre is long-standing, and in 1987 Telecom Australia (now Telstra) granted the Teletraffic Research Centre status as a Centre of Excellence in Teletraffic Engineering. The two organisations have had a relationship ever since and have kept pace with change. This mobile network dimensioning tool has operated throughout the introduction of the iPhone and other smart phone technologies, and has lasted through 10 upgrades of Ericsson’s network system. Associate Professor Northcote gave credit to Telstra for driving innovation, adding that Telstra was considered the highest quality network in Australia. What’s more, Telstra estimates the Devil tool has made its capital expenditure program some tens of percent more efficient, and led to significant savings in operational expenditure. The Devil tool has been so successful that in 2012, Hong Kong mobile operator CSL introduced the tool to its network. Adelaide Research and Innovation, which has licensed the technology back from Telstra to commercialise it on the global stage, has engaged Ascom (an international provider of wireless communications solutions) to act as a distribution partner. Associate Professor Northcote said the relationship with Telstra, and this project in particular, has always been commercially focused, and as a result is a commercial success. “Over the years, research has needed to become more focused on the bottom line and adapt to changes in the university sector,” he said. It is safe to say that the partnership between Telstra and the University of Adelaide is one example of two organisations working collaboratively to drive innovation that benefits not only them, but the community at large. Research Impact 59 This collaboration will lead to major improvements ... which in turn will keep the Australian defence forces at the forefront of technological advances. 60 Research Impact Mission-critical systems in Defence The Defence Science and Technology Organisation (DSTO) has brought together some of the State’s leading computer experts to solve key challenges in defence system design. The University of Adelaide’s School of Computer Science, together with the Defence Systems Innovation Centre, has developed a complete System Execution Modelling (SEM) laboratory environment for the analysis of submarine combat systems. This collaboration will lead to major improvements in system performance and design, which in turn will keep the Australian defence forces at the forefront of technological advances. According to DSTO computer systems engineer Gavin Puddy, it’s common within defence sectors to require system life cycles to extend far beyond those of similar civilian systems. “Also known as missioncritical systems, these types of systems continue to grow in complexity and cost as business owners seek continual capability improvements to satisfy operational requirements over these long life cycles,” he said. A submarine combat system is one such example of a long-lived missioncritical system. Its primary purpose is to develop a situational awareness of its environment through the use of sensors, identification of threats and to affect its environment as required. There are extra costs and complexities introduced because submarine combat systems operate within a constrained computing environment. “The ability to easily add more computing resources to resolve performance issues is not possible, as this may impact the overall platform,” Gavin said. “As a result, there is a strong desire to understand system performances as early as possible within the development and evolution cycles.” The current project uses model-driven engineering and development techniques, computational workload emulation modelling and the ability to deploy onto actual system infrastructure, as dictated by the system design. This gives a detailed insight into such things as integration, interfacing and timing performances. “It will also be able to provide insight into system space, weight and power requirements and provide insight into the margins of each,” Gavin said. “All of which are important performance indicators when designing and evolving computing resourceconstrained systems.” Gavin said the collaboration, which has been running for several years, has given system developers insight into the behaviour of the non-functional aspects of a system design early within the development life cycle. “Furthermore, its ability to conduct system testing during the conceptual design phase enables risks to be identified, managed and retired much earlier than traditional methods,” he said. This project has led to a strong working relationship between the partners, as well as fostering an international working relationship. It has laid the foundation for further research of early analysis into real-time and embedded system performances and other related system design aspects, as well as delivering an initial analysis environment that could start to provide support and insight for defence projects. The next step of the project is to introduce improved modelling techniques and definitions, as well as new runtime and analysis capabilities, and look to provide insight into the system-of-system design and development space. It is through innovative collaborations such as this that our defence forces continue to successfully operate in a highly technical world. Research Impact 61 For further information, please contact Office of the Deputy Vice-Chancellor & Vice-President (Research) The University of Adelaide SA 5005 Australia Telephone: +61 8 8313 3278 Email: enquiries.dvcr@adelaide.edu.au facebook.com/uniofadelaide twitter.com/uniofadelaide