GAOYANG LIANG, Ph.D.
CONTACT
Address:
Dr. Yi Zhang’s Laboratory
Program of Cellular and Molecular Medicine, Children’s Hospital Boston
Department of Genetics, Harvard Medical School
200 Longwood Ave, WAB-164
Boston, MA, 02115
Work phone:
617-713-8663
Email:
Gaoyang.Liang@childrens.harvard.edu
EDUCATION
2006 – 2012
University of North Carolina at Chapel Hill
Ph.D. in Biochemistry and Biophysics
Advisor: Dr. Yi Zhang
Dissertation: Improve induced pluripotent stem cell generation by
manipulating epigenetic statuses
2002 – 2004
University of Western Ontario, Canada
M.S. in Biochemistry
Advisor: Dr. Chris Brandl
Thesis: Regulation of the yeast SAGA complex
1998 – 2002
Sun Yat-Sen University, China
B.S. in Biochemistry
Advisor: Dr. Anlong Xu
Thesis: The polymorphism of HLA-DR locus in the Mongolian
population in Northern China
ACADEMIC HONORS
International Graduate Student Scholarship
University of Western Ontario 2002–2004
Special University Scholarship
University of Western Ontario 2002–2004
Excellent Student Scholarship, 2nd Prize
Sun Yat-Sen University
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1999–2001
CV: Gaoyang Liang, PhD
WORKING EXPERIENCE
2012 – current
Postdoctoral Research Fellow, Harvard Medical School
Principle Investigator: Dr. Yi Zhang
2005 – 2006
Research Technician, University of North Carolina at Chapel Hill
Principle Investigator: Dr. Yi Zhang
PUBLICATIONS
1.
Liang, G. and Zhang, Y. (2013) Embryonic stem cell and induced pluripotent stem
cell: an epigenetic perspective. Cell Res, 23(1), 49-69. doi:10.1038/cr.2012.175.
2.
Liang, G., He, J., and Zhang, Y. (2012) Kdm2b promotes induced pluripotent stem
cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol,
14(5), 457-466. doi: 10.1038/ncb2483.
3.
Liang, G., Taranova, O., Xia, K., and Zhang, Y. (2010) Butyrate promotes induced
pluripotent stem cell generation. J Biol Chem, 285(33), 25516-25521. doi:
10.1074/jbc.M110.142059.
4.
Tateishi, K., He, J., Taranova, O., Liang, G., D'Alessio, A.C., and Zhang, Y. (2008)
Generation of insulin-secreting islet-like clusters from human skin fibroblasts. J Biol
Chem, 283(46), 31601-31607. doi: 10.1074/jbc.M806597200.
5.
Liang, G.*, Klose, R.J.*, Gardner, K.E., and Zhang, Y. (* equal contribution).
(2007) Yeast Jhd2p is a histone H3 Lys4 trimethyl demethylase. Nat Struct Mol Biol,
14(4), 243-245.
6.
Fang, J., Hogan, G.J., Liang, G., Lieb, J.D., and Zhang, Y. (2007) The
Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of
H3K36me2. Mol Cell Biol, 27(13), 5055-5065.
7.
Klose, R.J., Gardner, K.E., Liang, G., Erdjument-Bromage, H., Tempst, P., and
Zhang, Y. (2007) Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of
an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol, 27(11),
3951-3961.
8.
Hoke, S.M., Genereaux, J., Liang, G., and Brandl, C.J. (2008) A conserved central
region of yeast Ada2 regulates the histone acetyltransferase activity of Gcn5 and
interacts with phospholipids. J Mol Biol, 384(4), 743-755. doi:
10.1016/j.jmb.2008.09.088.
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CV: Gaoyang Liang, PhD
9.
Mutiu, A.I., Hoke, S.M., Genereaux, J., Liang, G., and Brandl, C.J. (2007) The role
of histone ubiquitylation and deubiquitylation in gene expression as determined by
the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain. Mol Genet
Genomics, 277(5), 491-506.
10.
Hoke, S.M.*, Liang, G.*, Mutiu, A.I., Genereaux, J., and Brandl, C.J. (* equal
contribution). (2007) C-terminal processing of yeast Spt7 occurs in the absence of
functional SAGA complex. BMC Biochem, 8, 16.
CONFERENCE PRESENTATION
1.
Liang, G., He, J., and Zhang, Y. Kdm2b enhances iPS cell generation by facilitating
gene activation in early stage of reprogramming. Poster presentation. The 10th
ISSCR Annual Meeting; Jun 2012; Yokohama, Japan.
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