Figure 1. Example of a generic AOP diagram
MIE
KER1
KE1
KER2
KEn-1
KERn-1
KEn
KERn
AO
Figure 2. Overview of the organization of content pages in the AOPwiki relative to sections of the AOP template. Sections 1, 4, 5a, and 7
are found on the main page for an individual AOP. Information related
to sections 5b and section 6 are entered into separate content pages
that can be linked to multiple individual AOP pages.
Section 5b – MIE, KE, and AO descriptions
KE Pages
AOP Page
Section 1 - Title
• Description
• Measurement/
detection
• Taxonomic
applicability
Section 4 – Abstract
Section 5a – Summary of the AOP
MIE
KEs
AO
MIE Page
Chemical initiator(s)
• Description
• Measurement/
detection
• Taxonomic
applicability
• Evidence for
chemical initiation
Linkage table
AO Page
Key Event Relationships
KER Pages
Applicability domain(s) of the AOP
Life-stage
Taxonomic
Sex
Section 7 – Overall Assessment of the AOP
Modified Bradford Hill
Considerations
Title
Description
Biological plausibility
Empirical support
Inconsistencies and
uncertainties
• Quantitative
understanding
•
•
•
•
•
Section 6 – Scientific evidence supporting the linkages in the AOP
• Description
• Measurement/
detection
• Taxonomic
applicability
• Regulatory relevance
Figure 3. Generic AOP diagram illustrating the distinction between two types of key event relationships [KERs]. Both connections
represent a predictive relationship between a pair of key events and can be supported by weight of evidence. However, Direct KERs
represent direct causal connections while Indirect KERs represent correlation or indirect causal connections mediated by another key
event (or a gap in current understanding).
Indirect KER
Indirect KER
MIE
KER1
KE1
KER2
KEn-1
Indirect KER
KERn-1
KEn
KERn
AO
AOP Wiki – Screen Shot 1
Section 1 – AOP Identifier/Title
AOP Wiki – Screen Shot 2
Section 2,3,4 – Authors, Status, Abstract
AOP Wiki – Screen Shot 3
Section 2, 3 – Authors of AOP; Date of Updating of AOP
AOP Wiki – Screen Shot 4
Section 5a – Summary of the AOP as Figure/AOP Diagram
AOP Wiki – Screen Shot 5
Section 5a – Summary of the AOP Table of Key Events
and Key Event Relationships
List of Key Events,
including the MIE and
AO
AOP Wiki – Screen Shot 6a
Section 5b – Key Event Description Page (Structured content)
Note – Key event description pages
may link to more than one AOP
Taxonomic applicability
AOP Wiki – Screen Shot 6b
Section 5b – Key Event Description Page (Textual content)
Description of the biology
Measurement and detection
Taxonomic applicability
AOP Wiki – Screen Shot 7a
Section 5b – Molecular Initiating Event Description Page (structured content)
Note – MIE description pages may
link to more than one AOP
List of chemical initiators – links to structure
information and chemical initiator pages
Taxonomic applicability
AOP Wiki – Screen Shot 7b
Section 5b – Molecular Initiating Event Description Page (textual content)
Description of the biology
Measurement and detection
Taxonomic applicability
Evidence for chemical initiation of the MIE
AOP Wiki – Screen Shot 8
Section 5b – Adverse Outcome Description Page
Note – AO description pages may
link to more than one AOP
Description of the biology
Measurement and detection
Regulatory relevance
AOP Wiki – Screen Shot 9
Section 6 – Key Event Relationship Table
Linkage table:
Pairwiserelationships
between key
events
AOP Wiki – Screen Shot 10a
Section 6 – Key Event Relationship Page (structured content)
Title
Note – KER description pages may
link to more than one AOP.
Taxonomic applicability
AOP Wiki – Screen Shot 10b
Section 6 – Key Event Relationship Page (textual content)
Biological Plausibility
Empirical Support
Quantitative Understanding
Uncertainties or inconsistencies
Taxonomic applicability
AOP Wiki – Screen Shot 11a
Section 7 – Overall Assessment of the AOP
AOP Wiki – Screen Shot 11b
Section 7 – Overall Assessment of the AOP
AOP Wiki – Screen Shot 11c
Section 7 – Overall Assessment of the AOP
AOP Wiki – Screen Shot 11d
Section 7 – Overall Assessment of the AOP