EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q1IsyourInstitution: Répondues:47 Ignorées:0 Auniv ersity hospital Apriv ate hospital Othertype ofhospital 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Auniversityhospital 80,85% Aprivatehospital 6,38% 3 Othertypeofhospital 12,77% 6 Total 38 47 1/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q2YouremailAddressis: Répondues:45 Ignorées:2 2/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q3Wouldyoubecomfortableifwe acknowledgeyourcentreintheEuropace JournalandontheWebsite Répondues:47 Ignorées:0 Yes No 0% 20% 40% 60% Choixderéponses Réponses Yes 95,74% No 4,26% Total 80% 100% 45 2 47 3/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q4Doyouhavecardiacsurgeryatyour institution Répondues:47 Ignorées:0 Yes No 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Yes 80,85% 38 No 19,15% 9 Total 47 4/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q5Numberofimplantations(sumofnew implantsandreplacements)atyour institutionlastcalendaryear: Répondues:47 Ignorées:0 None 1-99 100-199 200-399 400ormore 0% 20% 40% 60% 80% 100% Choixderéponses Réponses None 2,13% 1 1-99 10,64% 5 100-199 8,51% 4 200-399 42,55% 20 400ormore 36,17% 17 Total 47 5/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q6TotalNumberofcatheterablations(all typesofarrhythmia)atyourinstitutionlast calendaryear: Répondues:47 Ignorées:0 None 1-99 100-199 200-399 400ormore 0% 20% 40% 60% 80% 100% Choixderéponses Réponses None 10,64% 5 1-99 19,15% 9 100-199 14,89% 7 200-399 34,04% 16 400ormore 21,28% 10 Total 47 6/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q7NumberofPacemakerimplantations (IncludingCRT-Ps)atyourinstitution (includingboxchanges)lastcalendaryear Répondues:47 Ignorées:0 None 1-99 100-199 200-399 400ormore 0% 20% 40% 60% 80% 100% Choixderéponses Réponses None 4,26% 2 1-99 8,51% 4 100-199 19,15% 9 200-399 57,45% 27 400ormore 10,64% 5 Total 47 7/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q8Numberofinvasivecoronary interventionprocedures (angioplasty/stenting)peryearinyour institutionaverages: Répondues:43 Ignorées:4 None Upto100 101–500 501–1000 >1000 0% 20% 40% 60% 80% 100% Choixderéponses Réponses None 4,65% 2 Upto100 6,98% 3 101–500 6,98% 3 501–1000 23,26% 10 >1000 58,14% 25 Total 43 8/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q9HowmanyAFpatientsonNOACs(i.e., dabigatran,rivaroxabanorapixaban)who sufferedanacutecoronarysyndrome (ACS)haveyouseeninyourclinical practicesofar? Répondues:43 Ignorées:4 None ≤50patients 51-100 patients >100patients 0% 20% 40% 60% 80% 100% Choixderéponses Réponses None 25,58% 11 ≤50patients 48,84% 21 51-100patients 9,30% 4 >100patients 16,28% 7 Total 43 9/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q10Whatisthepreferredstrategyinyour centreforAFpatientspresentingwith STEMIwithinanoptimaltimeframefor intervention,whoarealreadytaking warfarinoraNOAC? Répondues:43 Ignorées:4 10/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in ForAFpatientstakingaVitam inKantagonist(VKA) Oneansw er persection 0% 20% 40% 60% 80% 100% PrimaryPCIwithuninterruptedwarfarinregardlessoftheINRvalue PrimaryPCIwithuninterruptedwarfarinonlyiftheINRisbelow(please,statethec ut-offvalue) Fibrinolytic therapy Conservativetreatment 11/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in ForAFpatientstakinganoveloralanticoagulant(NOAC) Oneansw er persection 0% 20% 40% 60% 80% 100% PrimaryPCIwithuninterruptedNOAC PrimaryPCIwithtemporaryNOACdisc ontinuation Fibrinolytic therapy Conservativetreatment ForAFpatientstakingaVitaminKantagonist(VKA) PrimaryPCIw ithuninterrupted w arfarinregardlessoftheINR v alue One PrimaryPCIw ithuninterruptedw arfarinonlyif theINRisbelow (please,statethecut-offv alue) 58,14% 34,88% 12/31 Fibrinolytic therapy Conserv ativ e treatment Total 6,98% 0% 43 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in One answerper sec tion 58,14% 25 34,88% 15 6,98% 3 0% 0 43 ForAFpatientstakinganov eloralanticoagulant(NOAC) PrimaryPCIw ith uninterruptedNOAC Oneanswerper sec tion PrimaryPCIw ithtemporaryNOAC discontinuation 37,21% 16 55,81% 24 13/31 Fibrinolytic therapy 6,98% 3 Conserv ativ e treatment Total 0% 0 43 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q11Whichperi-proceduralantithrombotic medicationdoyoupreferablychoosefor yourAFpatientsalreadyunderVKA treatmentundergoingprimaryPCIfor STEMI(please,tickallmedicationsyouuse ontopofaVKA): Répondues:43 Ignorées:4 No additional antithromb... Aspirin Clopidogrel Prasugrelor Ticagrelor Heparin (unfractionat edorLMWH) GPIIb/IIIa inhibitors Idonot personally perform... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Noadditionalantithrombotic medic ation 4,65% Aspirin 83,72% 36 Clopidogrel 69,77% 30 PrasugrelorTic agrelor 23,26% 10 Heparin(unfrac tionatedorLMWH) 32,56% 14 GPIIb/IIIainhibitors 6,98% 3 Idonotpersonallyperforminvasivec oronaryproc edures(angioplasty/stenting)andc annotanswerthisquestion 2,33% 1 Nombretotalderépondants:43 14/31 2 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q12Whichperi-proceduralantithrombotic medicationdoyoupreferablychoosefor yourAFpatientsunderNOACtreatment undergoingprimaryPCIforSTEMI(please, tickallmedicationsyouuseontopofa NOAC): Répondues:43 Ignorées:4 No additional antithromb... Aspirin Clopidogrel Prasugrelor Ticagrelor Heparin (unfractionat edorLMWH) GPIIb/IIIa inhibitors Idonot personally perform... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Noadditionalantithrombotic medic ation 11,63% 5 Aspirin 74,42% 32 Clopidogrel 67,44% 29 PrasugrelorTic agrelor 16,28% 7 Heparin(unfrac tionatedorLMWH) 30,23% 13 GPIIb/IIIainhibitors 9,30% 4 Idonotpersonallyperforminvasivec oronaryproc edures(angioplasty/stenting)andc annotanswerthisquestion 2,33% 1 Nombretotalderépondants:43 15/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q13Doyouroutinelytemporarilystoporal anticoagulanttherapyinyourAFpatient presentingwithanNSTE-ACS? Répondues:39 Ignorées:8 Yes,alw ays Yes,aVKA Yes,aNOAC No 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Yes,always 35,90% 14 Yes,aVKA 10,26% 4 Yes,aNOAC 20,51% 8 No 33,33% 13 Total 39 16/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q14Howdoyoucommonlyestimatethe risksofAF-relatedthromboembolic events,ischemiceventsandbleedingin AFpatientspresentingwithaNSTE-ACS? Répondues:39 Ignorées:8 Using common clinical sense TheGRACE score TheTIMI score The CRUSADE score The ACUITY/HORIZO NSderiv ed... TheCHADS2 score 17/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in The CHA2DS2VASc score TheHASBLED score Other (please, state) 0% 20% 40% 60% TheriskofAF-relatedthromboembolic events 80% 100% Theriskofisc hemic events Theriskofbleeding TheriskofAF-related thromboembolicev ents Theriskofischemic ev ents Theriskof bleeding Nombretotalde répondants Usingc ommonc linic alsense 61,11% 11 77,78% 14 61,11% 11 36 TheGRACEsc ore 17,65% 3 82,35% 14 0% 0 17 TheTIMIsc ore 0% 0 73,33% 11 33,33% 5 16 TheCRUSADEsc ore 0% 0 25% 1 75% 3 4 TheACUITY/HORIZONS derivedsc ore 0% 0 50% 2 50% 2 4 TheCHADS2sc ore 100% 9 0% 0 11,11% 1 10 TheCHA2DS2-VASc sc ore 100% 36 16,67% 6 5,56% 2 44 TheHAS-BLEDsc ore 2,94% 1 0% 0 97,06% 33 34 0% 0 0% 0 0% 0 0 Other(please,state) 18/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q15Whatfirst-linepharmacological therapydoyoupreferablyuseinAF patientspresentingwithaNSTE-ACSwho arealreadytakingaVKAoraNOAC (please,tickallmedicationsyouuse): Répondues:39 Ignorées:8 No additional antithromb... Aspirin Clopidogrel Prasugrelor Ticagrelor Heparin (unfractionat edorLMWH) GPIIb/IIIa inhibitors 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Noadditionalantithrombotic medic ation 0% Aspirin 76,92% 30 Clopidogrel 74,36% 29 PrasugrelorTic agrelor 17,95% 7 Heparin(unfrac tionatedorLMWH) 30,77% 12 GPIIb/IIIainhibitors 0% Nombretotalderépondants:39 19/31 0 0 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q16Whichaccessroute(puncturesite)is usedatyourcentreinAFpatientsona VKA/NOAC,undergoingcoronary angiographyoraPCIwithstenting? Répondues:39 Ignorées:8 Femoral Radial, alw ays Radial,if theoperator hasadequa... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Femoral 17,95% 7 Radial,always 38,46% 15 Radial,iftheoperatorhasadequateexperienc e 43,59% 17 Total 39 20/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q17Whichstenttypeispreferablyusedat yourcentreforprimaryPCIinAFpatients withSTEMI,takingaVKA/NOAC? Répondues:39 Ignorées:8 OtherStent (seebelow ) Drug-eluting stents Drug-eluting stents,if therisko... Bare-metal stents Otherstents (please, statew hic... Wedonot hav ea specific... Other(See below ) 0% 20% 40% 60% 80% 100% Choixderéponses Réponses OtherStent(seebelow) 0% 0 Drug-elutingstents 12,82% 5 Drug-elutingstents,iftheriskofbleedingwithsubsequenttripletherapyisnottoohigh 12,82% 5 Bare-metalstents 53,85% 21 Otherstents(please,statewhic hone) 2,56% 1 Wedonothaveaspec ific strategyforthesepatients 15,38% 6 Other(Seebelow) 2,56% 1 Total 39 21/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q18Whichofthefollowingtreatment modalitiesdoyouuseinyourclinical practiceregardingAFpatientspresenting withaNSTE-ACS,whoaretakinga VKA/NOAC? Répondues:39 Ignorées:8 Inv asiv e strategies (coronary... Bare-metal stentsare preferred... Soleballoon angioplasty insteadof... Bypass surgery insteadof... Nospecific measure taken 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Invasivestrategies(c oronaryangiographyandrevasc ularization)shouldbedelayedaslongaspossibleinsuc hpatients 25,64% 10 Bare-metalstentsarepreferredabovedrug-elutingstentstoshortenexposuretodualortripletherapy 74,36% 29 Soleballoonangioplastyinsteadofstentimplantationshouldbec onsideredinAFpatientsathighbleedingriskrequiringtriple therapy 17,95% 7 BypasssurgeryinsteadofPCIstentingshouldbec onsideredinAFpatientsathighbleedingriskwithtripletherapy 15,38% 6 Nospec ific measuretaken 10,26% 4 Nombretotalderépondants:39 22/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q19Doyouroutinelycontinuewithtriple therapy(thatis,anoralanticoagulantplus twoantiplateletdrugs)inallpatientswith AFandSTEMIwhounderwentPCIwith stenting? Répondues:39 Ignorées:8 Yes No,Iuse triple therapyon... No,Iuse triple therapyon... No,Iuse triple therapyon... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses 41,03% 16 Yes 15,38% 6 No,IusetripletherapyonlyinAFpatientsatmoderate-to-highriskofthromboembolic eventsregardlessofthebleedingrisk. 28,21% 11 No,IusetripletherapyonlyinAFpatientsatmoderate-to-highriskofthromboembolic eventsiftheriskofbleedingisnottoohigh 15,38% No,IusetripletherapyonlyinAFpatientswithdrug-elutingstentsatmoderate-to-highriskofthromboembolic eventsiftheriskof bleedingisnottoohigh. Total 6 39 23/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q20Whichcombination(s)offollowing drugsdoyoupreferablyusefortriple therapyinyourAFpatientsafteranACS? (please,tickalloptionsyouwouldchoose) Répondues:39 Ignorées:8 Warfarin(or otherVKA) w iththeI... Warfarin(or otherVKA) w iththeI... Dabigatran 150mgbid Dabigatran 110mgbid Riv aroxaban 20mgonce daily Riv aroxaban 15mgonce daily 24/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Apixaban 5mg bid Apixaban 2.5mgbid 0% 20% Aspirin+Clopidogrel 40% Aspirin+Prasugrel Aspirin+ Clopidogrel 60% 80% 100% Aspirin+Tic agrelor Aspirin+ Prasugrel Aspirin+ Ticagrelor Nombretotalde répondants Warfarin(orotherVKA)withtheINR2.02.5 88,24% 30 17,65% 6 20,59% 7 43 Warfarin(orotherVKA)withtheINR2.03.0 81,25% 13 18,75% 3 25% 4 20 Dabigatran150mgbid 77,78% 7 22,22% 2 22,22% 2 11 Dabigatran110mgbid 87,50% 14 12,50% 2 12,50% 2 18 Rivaroxaban20mgonc edaily 75% 6 37,50% 3 37,50% 3 12 Rivaroxaban15mgonc edaily 83,33% 10 25% 3 16,67% 2 15 75% 3 50% 2 25% 1 6 90,91% 10 18,18% 2 9,09% 1 13 Apixaban5mgbid Apixaban2.5mgbid 25/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q21Howlongdoyoucontinuetriple therapyinAFpatientsafterprimaryPCI withstenting? Répondues:39 Ignorées:8 9-12months, regardlessof thebleedi... Atleast1 monthfor bare-metal... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses 15,38% 6 9-12months,regardlessofthebleedingrisk 84,62% Atleast1monthforbare-metalstentsandatleast3-6monthsfordrug-elutingstents(dependingonthestenttype),partic ularlyifthe riskofbleedingishigh 33 Total 39 26/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q22Howlongdoyoucontinuedual therapy(i.e.,anoralanticoagulantplusan antiplateletdrug)inAFpatientsafter primaryPCIwithstentingforSTEMI? Répondues:39 Ignorées:8 12months, alw ays 1month,if bare-metal stentsw er... Indefinitely 0% 20% 40% 60% 80% 100% Choixderéponses Réponses 12months,always 58,97% 23 1month,ifbare-metalstentswereusedand3-6months,ifdrug-elutingstentswereused 25,64% 10 Indefinitely 15,38% 6 Total 39 27/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q23Howlongdoyoucontinuewithtriple treatmentinyourAFpatientafteraNSTEACS? Répondues:39 Ignorées:8 •12months, alw ays •1month, ifbare-metal stentsw er... •Indefinitel y 0% 20% 40% 60% 80% 100% Choixderéponses Réponses •12months,always 25,64% 10 •1month,ifbare-metalstentswereusedand3-6months,ifdrug-elutingstentswereused 69,23% 27 •Indefinitely 5,13% Total 2 39 28/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q24Whendoyoure-initiatepreviously discontinuedNOACtherapyinAFpatients presentingwithanACSwhounderwent PCIwithstenting? Répondues:39 Ignorées:8 Immediately w hen parenteral... Other Within24 hoursafter thePCIw i... >24hours afterthePCI w ithstenting Other 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Immediatelywhenparenteralantic oagulationisstopped 17,95% 7 Other 0% 0 Within24hoursafterthePCIwithstenting 28,21% 11 >24hoursafterthePCIwithstenting 43,59% 17 Other 10,26% 4 Total 39 29/31 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q25Doyoucontinuewiththesameoral anticoagulantdrugthatpatienthasbeen takingbeforeACS? Répondues:39 Ignorées:8 Yes No,Ioften sw itchfroma NOACtoa VKA No,Ioften sw itchfroma VKAtoaN... 0% 20% 40% 60% 80% 100% Choixderéponses Réponses Yes 64,10% 25 No,Ioftenswitc hfromaNOACtoaVKA 28,21% 11 No,Ioftenswitc hfromaVKAtoaNOAC(please,tic kthepreferredNOAC) 7,69% Nombretotalderépondants:39 30/31 3 EPWIREonEuropeanManagementStrategyforAcuteCoronarySyndromes(ACS)in Q26Whenitcomestodualtreatmentpost ACS,whichantiplateletdrugdoyou preferablycombinewithwarfarin(orother VKA)oraNOACinyourAFpatient? Répondues:39 Ignorées:8 Aspirin Clopidogrel Prasugrel Ticagrelor 0% 20% 40% Withwarfarin(orotherVKA) 60% 80% 100% WithaNOAC Withw arfarin(orotherVKA) WithaNOAC Nombretotalderépondants Aspirin 88% 22 60% 15 37 Clopidogrel 96% 24 48% 12 36 Prasugrel 75% 6 37,50% 3 9 55,56% 5 55,56% 5 10 Tic agrelor 31/31