A BODY OF EVIDENCE The benefits of taking nutritional supplements are well established, and when you take Modere nutritional supplements you know those benefits are underpinned by our absolute commitment to safety-conscious products, quality ingredients and good corporate citizenship. CIRCULATION For all manner of reasons — particularly poor diet, poor lifestyle choices or illness — we may not receive all of the nutritional requirements our body requires to operate at optimum efficiency and underpin our overall wellbeing. When the intake of vitamins, minerals and other essential nutrients from dietary sources is deficient, supplementation may be the answer. Hawthorn Crataegus monogyna Possesses cardiotonic (strengthening the heart), coronary vasodilator (widens the arteries) and hypotensive (lowering blood pressure) properties. Which ingredients in which Modere products offer supporting research for their benefit to the various parts of your body? Here is a comprehensive overview that can help you discover for yourself and assist you to make recommendation when you’re asked — and we’ve added references if you want to learn more! For further specific information relating to health conditions, please refer to the product fact sheets, product usage guides and other downloads on modere.com.au and under ‘resources’ on the Shifting Retail site. *Please note, not all ingredients are listed, please refer to the website for full details. (COQ10, HAIR, SKIN AND NAILS) Grape Vitis vinifera For the treatment of circulatory disorders such as peripheral venous insufficiency Wohlmuth, H., Issue 3: Grape seed extract, Botanical Pathways Online, 2001. Barnes, Anderson & Phillipson, Herbal Medicines, 2nd Edition, Pharmaceutical Press: London, 2002. Horse Chestnut Aesculus hippocastanum Used to treat varicose veins, haemorrhoids, phlebitis and chronic venous insufficiency in the legs Barnes, Anderson & Phillipson, Herbal Medicines, 2nd Edition, Pharmaceutical Press: London, 2002. BONES (CALCIUM CHEWABLE, D3 PLUS, ESSENTIALS, ADULT MULTIVITAMIN, ADULT MULTIVITAMIN PLUS BOTANICALS, CHILDREN’S MULTIVITAMIN, MUSCLE AND BONE NUTRITION) Calcium Supports bone mineralisation and prevents osteoporosis Whitney & Rolfes, Understanding Nutrition, 10th Edition, Thomson Wadworth, 2005 Magnesium Involved in bone mineralisation Bannock, l., Clinical Human Nutrition, Human Nutrition.com, 2002 Vitamin D Promotes mineralisation of bones Whitney & Rolfes, Understanding Nutrition, 10th Edition, Thomson Wadworth, 2005 EYES (EFA KRILL, EYE HEALTH, ADULT MULTIVITAMIN, ADULT MULTIVITAMIN PLUS BOTANICALS, CHILDREN’S MULTIVITAMIN) DHA docosahexaenoic acid DHA plays an important role as a structural membrane lipid, particularly in the retina National Health and Medical Research Council, Nutrient Reference Values for Australia and New Zealand, Commonwealth of Australia Department of Health and Ageing 2006 Lutein Supports visual function; affects macular pigment optical density, visual acuity and glare recovery Richer et al, LAST study (Lutein Antioxidant Supplementation Trial) Optometry 75(4) Zinc Essential nutrient with a stated use in night blindness Whitney & Rolfes, Understanding Nutrition, 6th Edition, West Publishing Company: Minneapolis/ St Paul, 1993. BRAIN, MEMORY & CONCENTRATION (FOCUS, D3 PLUS, ENERGY SHOT, IN FOCUS) Brahmi Bacopa monnieri Medicinal uses include as a brain tonic for improving memory, concentration and learning Kerry Bone, Clinical applications of Ayurvedic and Chinese herbs, Phytotherapy Press, 1997 Ginkgo Ginkgo biloba Ginkgo is traditionally used for cognitive function Barnes, Anderson & Phillipson, Herbal Medicines, 2nd Edition, Pharmaceutical Press: London, 2002. DIGESTION (FIBER, PROBIOTIC, PARA CLEANSE, DIGESTIVE ENZYMES, MEXICAN WILD YAM) Probiotic bacteria Lactobacillus acidophilus, Bifidobacterium lactis Bifidobacteria and Lactobacilli may reduce constipation James P. Meschino, Probiotics in Clinical Practice: An Update, Dynamic Chiropractic – Nov 4, 2011, Vol. 29, Issue 23 Psyllium Husk Adequate dietary fibre is essential for proper functioning of the gut and digestion National Health and Medical Research Council, Nutrient Reference Values for Australia and New Zealand, Commonwealth of Australia Department of Health and Ageing 2006 Wormwood Artemisia absinthium Tonic for the digestive system, helps neutralise disruptive bowel flora Senior Ed: Blumenthal, M., The Complete German Commission E Monographs, American Botanical Council: Texas, 1988 ENERGY, STAMINA (WELL-BEING, ENDURANCE, ENERGY SHOT, IMMUNE HEALTH, COLOSTRUM) Cordyceps sinensis Traditionally used for fatigue, low energy, physical and nervous exhaustion Daniel Reid, A Handbook of Chinese Healing Herbs, Simon & Schuster, 1995. Siberian Ginseng Eleutherococcus senticosus Powerful adaptogen; traditional usage is to increase the body’s resistance to stress and build up general vitality Barnes, Anderson & Phillipson, Herbal Medicines, 2nd Ed, Pharmaceutical Press: London, 2002. Reiishi Ganoderma lucidum Traditional actions include replenishing qi and easing the mind Pharmacopeia Commission of the Ministry of Public Health, Chinese Pharmacopeia, Pharmacopeia Commission of the Ministry of Public Health, 2000. IMMUNE SYSTEM (D3 PLUS, EFA KRILL, WELL-BEING, IMMUNE HEALTH, COLOSTRUM) Astragalus Astragalus membranaceus Immunostimulant and tonic; to prevent infection, impaired immunity Kerry Bone, Clinical applications of Ayurvedic and Chinese herbs, Phytotherapy Press, 1997. Colostrum Bovine colostrum is a rich source of natural immunoglobulins R. Pakkanen, J. Aalto, Growth factors and antimicrobial factors of bovine colostrum, International Dairy Journal, Volume 7, Issue 5, May 1997, Pages 285-297 Omega-3 fatty acids Omega-3 fatty acids have a variety of anti-inflammatory and immune-modulating effects Mori, Trevor A., and Lawrence J. Beilin, Omega-3 fatty acids and inflammation, Current atherosclerosis reports 6.6 (2004): 461-467. HORMONES (BALANCE, BALANCING CREAM, TRANSITIONS) Chaste Tree Vitex agnus – castus For menstrual cycle irregularities and other premenstrual symptoms Mills & Bone, Principles and Practice of Phytotherapy, Modern Herbal Medicine Kelp Contains iodine; essential to the production of thyroid hormones Whitney & Rolfes, Understanding Nutrition, 10th Edition, Thomson Wadworth, 2005 Rosemary Rosmarinus officinalis Traditionally indicated for headaches Barnes, Anderson & Phillipson, Herbal Medicines 2nd Edition, Pharmaceutical Press, 2002 Willow bark Salix alba Relief of headaches, analgesic and anti-inflammatory Peter R. Bradley (ed), British Herbal Compendium, British Herbal Medicine Association, 1992 HAIR, NAILS & SKIN (EFA KRILL, ADULT MULTIVITAMIN, HAIR, SKIN AND NAILS) Grape seed oil Vitis vinifera Helps to protect against inflammatory skin conditions Wohlmuth, H., Issue 3: Grape seed extract Botanical Pathways Online, 2001 Omega 3 Fatty Acids Fatty acids may be an effective adjunctive treatment for many skin disorders Meagen M. McCusker, MD, Jane M. Grant-Kels, MD, Healing fats of the skin: the structural and immunologic roles of the omega-6 and omega-3 fatty acids, Department of Dermatology University of Connecticut Health Center, 2010 Vitamin A Retinyl palmitate Essential nutrient involved in healthy epithelial tissues and growth Whitney & Rolfes, Understanding Nutrition, 10th Edition, Thomson Wadsworth, 2005 HEART DETOXIFICATION (COQ10, EFA KRILL) Coenzyme Q10 monograph, Alternative Medicine Review: Vol 12 No 2, 2007 (MODERE 12 WEEK DETOX PROGRAM AND FOOD LIST, FIBER, LIVER HEALTH, PARA CLEANSE, GREEN QI, PROBIOTIC, DIGESTIVE ENZYMES) Hawthorn Crataegus monogyna Indicated for complications of the heart and cardiovascular system St Mary’s Thistle Silybum marianum Effect on detoxification mechanisms; therapeutic effect on toxic hepatopathy Scientific Committee, British Herbal Pharmacopeia, British Herbal Medicine Association, 1995 Mills, S & Bone, K., Principles & Practice of Phytotherapy: Modern Herbal Medicine, Churchill Livingstone, 2000. Coenzyme Q10 Ubidecarenone CoQ10 levels are depleted with age Krill Euphausia superba Supports heart and cardiovascular health; supports healthy cholesterol and triglyceride levels Bunea et al, Evaluation of the effects of Neptune Krill Oil on the clinical course of hyperlipidemia, Alternative Medicine Review Vol 9 No 4, 2004 JOINTS (EFA KRILL, GLUCOSAMINE, ANTIINFLAMMATORY, JOINT NUTRITION) Glucosamine sulfate Effective in controlling symptoms in patients with active osteoarthritis of the knee Fabender et al, Glucosamine sulfate compared to ibuprofen in osteoarthritic of the knee, Osteoarthritis and cartilage 2 61-69, 1994 Krill Euphausia superba Reduces pain and inflammation associated with arthritis and improves joint mobility Deutsch, L., Evaluation of the effects of Neptune Krill Oil on chronic inflammation and arthritic symptoms, Journal of the American College of Nutrition Vol 26 No 1, 2007 ANTIOXIDANTS (COQ10, ANTIOXIDANT SUSTAINED RELEASE, EYE HEALTH, LIVER HEALTH, ANTIOXIDANT, CELL NUTRITION) Grape seed Vitis Vinifera Rich in particularly potent antioxidant polyphenols called procyanidin or OPCS Mills, S & Bone, K., Principles & Practice of Phytotherapy: Modern Herbal Medicine, Churchill Livingstone, 2000. Resveratrol Resveratrol found to be better than other common antioxidants in inhibiting lipid peroxidation Murcia MA, Martínez-Tomé M. Antioxidant activity of resveratrol compared with common food additives. J Food Prot. 2001 Mar; 64(3):379-84. Turmeric Curcuma longa Protects against free-radical peroxidation of membrane lipids and oxidative damage Menon & Sudheer, Antioxidant and antiinflammatory properties of curcumin, Adv Exp Med Biol 2007; 595:105-25 American Ginseng Panax quinquefolium Tonic for the digestive system; supports healthy digestion/ digestive function Barnes, Anderson & Phillipson, Herbal Medicines 2nd Edition, Pharmaceutical Press: London, 2002 Psyllium Husk Dietary fibre is the most effective treatment for all forms of constipation National Health and Medical Research Council, Nutrient Reference Values for Australia and New Zealand, Commonwealth of Australia Department of Health and Ageing 2006 STRESS (WELL-BEING, STRESS HEALTH, DE-STRESS) Lactium as1-casein hydrolysate Affects stress-related symptoms; displays anxiolytic activity, inhibits anxiety and the stress response D. Filbien and J. Tauzin. Stress management with a milk protein hydrolysate containing a bioactive peptide, Ingredia SA Korean Red Ginseng Panax ginseng Adaptogenic properties; enhancing body’s nonspecific resistance to external stresses Bradley, P.R. Ed., British Herbal Compendium Vol. 1, A Handbook of Scientific Information on Widely Used Plant Drugs St John’s Wort Hypericum perforatum Uses listed as for depressive moods, anxiety and/or nervous unrest Mitchell, H.W. (chairman), British Herbal Pharmacopoeia, British Herbal Medicine Association, 1983 *Please note, not all ingredients are listed, please refer to the website for full details.