A J OURNAL OF THE AMERICAN D IABETE S A SS OCIATION
February 2016 Volume 65, Number 2
IN THIS ISSUE
305
381
MK2 Deletion in Mice Prevents Diabetes-Induced
Perturbations in Lipid Metabolism and Cardiac Dysfunction
M. Ruiz, L. Coderre, D. Lachance, V. Houde, C. Martel,
J. Thompson Legault, M.-A. Gillis, B. Bouchard, C. Daneault,
A.C. Carpentier, M. Gaestel, B.G. Allen, and C. Des Rosiers
393
Activation of ERK1/2 Ameliorates Liver Steatosis in
Leptin Receptor–Deficient (db/db) Mice via Stimulating
ATG7-Dependent Autophagy
Y. Xiao, H. Liu, J. Yu, Z. Zhao, F. Xiao, T. Xia, C. Wang, K. Li, J. Deng,
Y. Guo, S. Chen, Y. Chen, and F. Guo
In This Issue of Diabetes
PERSPECTIVES IN DIABETES
307
Type 1 Diabetes—Reaping the Rewards of a Targeted
Research Investment
J.E. Fradkin, J.A. Wallace, B. Akolkar, and G.P. Rodgers
314
Endocrine Pancreas Development and Regeneration:
Noncanonical Ideas From Neural Stem Cell Biology
J. Masjkur, S.W. Poser, P. Nikolakopoulou, G. Chrousos,
R.D. McKay, S.R. Bornstein, P.M. Jones, and
A. Androutsellis-Theotokis
331
Gasotransmitters in Vascular Complications of Diabetes
J.C. van den Born, H.-P. Hammes, W. Greffrath, H. van Goor, and
J.-L. Hillebrands, on behalf of the DFG GRK International Research
Training Group 1874 Diabetic Microvascular Complications
(DIAMICOM)
OBESITY STUDIES
406
Obesity in MENX Rats Is Accompanied by High Circulating
Levels of Ghrelin and Improved Insulin Sensitivity
T. Wiedemann, M. Bielohuby, T.D. Müller, M. Bidlingmaier,
and N.S. Pellegata
421
Uroguanylin Action in the Brain Reduces Weight Gain
in Obese Mice via Different Efferent Autonomic
Pathways
C. Folgueira, D. Beiroa, A. Callon, O. Al-Massadi,
S. Barja-Fernandez, A. Senra, J. Fernø, M. López,
C. Dieguez, F.F. Casanueva, F. Rohner-Jeanrenaud,
L.M. Seoane, and R. Nogueiras
433
Numerous Genes in Loci Associated With Body Fat
Distribution Are Linked to Adipose Function
I. Dahlman, M. Rydén, D. Brodin, H. Grallert, R.J. Strawbridge,
and P. Arner
COMMENTARIES
346
A New Road for Treating the Vascular Complications
of Diabetes: So Let's Step on the Gas
J.L. Evans and I.D. Goldfine
349
Platelet Dysfunction in Type 1 Diabetes: Stressing the
Thromboxanes
J.A. Wisinski and M.E. Kimple
352
Reversibility of Defects in Proinsulin Processing and Islet
b-Cell Failure in Obesity-Related Type 2 Diabetes
C.J. Nolan and V. Delghingaro-Augusto
355
Diabetic Central Neuropathy: CNS Damage Related
to Hyperglycemia
J.I. Malone
ISLET STUDIES
438
Pancreatic b-Cell Adaptive Plasticity in Obesity Increases
Insulin Production but Adversely Affects Secretory
Function
C. Alarcon, B.B. Boland, Y. Uchizono, P.C. Moore, B. Peterson,
S. Rajan, O.S. Rhodes, A.B. Noske, L. Haataja, P. Arvan, B.J. Marsh,
J. Austin, and C.J. Rhodes
451
Antiaging Glycopeptide Protects Human Islets Against
Tacrolimus-Related Injury and Facilitates Engraftment
in Mice
B.L. Gala-Lopez, A.R. Pepper, R.L. Pawlick, D. O’Gorman,
T. Kin, A. Bruni, N. Abualhassan, M. Bral, A. Bautista,
J.E. Manning Fox, L.G. Young, P.E. MacDonald, and
A.M.J. Shapiro
METABOLISM
358
371
Skeletal Muscle Phospholipid Metabolism Regulates
Insulin Sensitivity and Contractile Function
K. Funai, I.J. Lodhi, L.D. Spears, L. Yin, H. Song, S. Klein, and
C.F. Semenkovich
TCF7L2 Genotype and a-Cell Function in Humans
Without Diabetes
M. Shah, R.T. Varghese, J.M. Miles, F. Piccinini, C. Dalla Man,
C. Cobelli, K.R. Bailey, R.A. Rizza, and A. Vella
Keep up with the latest information for Diabetes and other ADA titles
via Facebook (/ADAJournals) and Twitter (@ADA_Journals).
All articles in Diabetes are available online at diabetes.org/diabetes,
are available free to print subscribers, or can be purchase as e-prints
or reprints.
ADA’s Diabetes Core Update podcast is available at diabetesjournals
.org and through iTunes.
Icons shown below appear on the first page of an article if more
information is available online.
463
Metabolism Regulates Exposure of Pancreatic Islets
to Circulating Molecules In Vivo
A. Michau, D.J. Hodson, P. Fontanaud, A. Guillou,
G. Espinosa-Carrasco, F. Molino, C.J. Peters, I.C. Robinson,
P. Le Tissier, P. Mollard, and M. Schaeffer
527
Loss-of-Function Mutations in the Cell-Cycle Control Gene
CDKN2A Impact on Glucose Homeostasis in Humans
A. Pal, T.P. Potjer, S.K. Thomsen, H.J. Ng, A. Barrett, R. Scharfmann,
T.J. James, D.T. Bishop, F. Karpe, I.F. Godsland, H.F.A. Vasen,
J. Newton-Bishop, H. Pijl, M.I. McCarthy, and A.L. Gloyn
PATHOPHYSIOLOGY
ERRATUM
476
534
Variations in Brain Volume and Growth in Young Children
With Type 1 Diabetes
P.K. Mazaika, S.A. Weinzimer, N. Mauras, B. Buckingham,
N.H. White, E. Tsalikian, T. Hershey, A. Cato, T. Aye, L. Fox,
D.M. Wilson, M.J. Tansey, W. Tamborlane, D. Peng, M. Raman,
M. Marzelli, and A.L. Reiss, for the Diabetes Research in Children
Network (DirecNet)
Erratum. Adoptive Transfer With In Vitro Expanded
Human Regulatory T Cells Protects Against Porcine
Islet Xenograft Rejection via Interleukin-10 in
Humanized Mice. Diabetes 2012;61:1180–1191
S. Yi, M. Ji, J. Wu, X. Ma, P. Phillips, W.J. Hawthorne,
and P.J. O’Connell
ISSUES AND EVENTS
COMPLICATIONS
535
486
e-LETTERS – COMMENTS AND RESPONSES
498
Measurements of CD34+/CD45-dim Stem Cells Predict
Healing of Diabetic Neuropathic Wounds
S.R. Thom, M. Hampton, M.A. Troiano, Z. Mirza, D.S. Malay,
S. Shannon, N.B. Jennato, C.M. Donohue, O. Hoffstad,
D. Woltereck, M. Yang, K. Yu, V.M. Bhopale, S. Kovtun, and
D.J. Margolis
Plasma Prekallikrein Is Associated With Carotid
Intima-Media Thickness in Type 1 Diabetes
M.A. Jaffa, D. Luttrell, A.H. Schmaier, R.L. Klein,
M. Lopes-Virella, L.M. Luttrell, A.A. Jaffa, and the DCCT/EDIC
Research Group
PHARMACOLOGY AND THERAPEUTICS
503
In Vivo Platelet Activation and Aspirin Responsiveness
in Type 1 Diabetes
F. Zaccardi, A. Rizzi, G. Petrucci, F. Ciaffardini, L. Tanese,
F. Pagliaccia, V. Cavalca, A. Ciminello, A. Habib,
I. Squellerio, P. Rizzo, E. Tremoli, B. Rocca, D. Pitocco,
and C. Patrono
GENETICS/GENOMES/PROTEOMICS/METABOLOMICS
510
520
Analysis of SLC16A11 Variants in 12,811 American
Indians: Genotype-Obesity Interaction for Type 2
Diabetes and an Association With RNASEK Expression
M. Traurig, R.L. Hanson, A. Marinelarena, S. Kobes, P. Piaggi,
S. Cole, J.E. Curran, J. Blangero, H. Göring, S. Kumar,
R.G. Nelson, B.V. Howard, W.C. Knowler, L.J. Baier, and
C. Bogardus
Lifestyle and Metformin Ameliorate Insulin Sensitivity
Independently of the Genetic Burden of Established
Insulin Resistance Variants in Diabetes Prevention
Program Participants
M.-F. Hivert, C.A. Christophi, P.W. Franks, K.A. Jablonski,
D.A. Ehrmann, S.E. Kahn, E.S. Horton, T.I. Pollin,
K.J. Mather, L. Perreault, E. Barrett-Connor, W.C. Knowler, and
J.C. Florez, for the Diabetes Prevention Program Research
Group
Issues and Events
e1
Comment on Patel et al. ACE2 Deficiency Worsens
Epicardial Adipose Tissue Inflammation and Cardiac
Dysfunction in Response to Diet-Induced Obesity.
Diabetes 2016;65:85–95
D. Montaigne, A. Coisne, X. Marechal, and B. Staels
e3
Response to Comment on Patel et al. ACE2 Deficiency
Worsens Epicardial Adipose Tissue Inflammation and
Cardiac Dysfunction in Response to Diet-Induced
Obesity. Diabetes 2016;65:85–95
V.B. Patel and G.Y. Oudit
e5
Comment on Giacco et al. GLP-1 Cleavage Product
Reverses Persistent ROS Generation After
Transient Hyperglycemia by Disrupting an
ROS-Generating Feedback Loop. Diabetes
2015;64:3273–3284
A. Ceriello and S. Genovese
e6
Response to Comment on Giacco et al. GLP-1 Cleavage
Product Reverses Persistent ROS Generation After
Transient Hyperglycemia by Disrupting an
ROS-Generating Feedback Loop. Diabetes
2015;64:3273–3284
M. Brownlee
e8
Comment on Yi et al. Adoptive Transfer With In Vitro
Expanded Human Regulatory T Cells Protects
Against Porcine Islet Xenograft Rejection via
Interleukin-10 in Humanized Mice. Diabetes
2012;61:1180–1191
Q. Ye, P. Zhang, and Q. Wan
e9
Response to Comment on Yi et al. Adoptive Transfer With
In Vitro Expanded Human Regulatory T Cells
Protects Against Porcine Islet Xenograft Rejection
via Interleukin-10 in Humanized Mice. Diabetes
2012;61:1180–1191
P.J. O'Connell and S. Yi
On the cover: A screen capture image of a three-dimensional reconstruction of electron microscope tomography analysis of a multivesicular body
commonly observed in hard-working pancreatic b-cells from db/db mice. This is a first three-dimensional view of this organelle, which is featured in
the article “Pancreatic b-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function” (p. 438) in this
issue of Diabetes.