DR. ANDLEEB KHAN
Address: Jazan, KSA
Telephone: 0594937800 (M)
Email: drandleebkhan@gmail.com
To work in a challenging and stimulating environment with best opportunities to use my current
experience and to enrich my knowledge and enhance my experience. To contribute towards the
achievement of organizational objective by applying my professional skills.
WORK EXPERIENCE

LECTURER from 16th Sep 2013 to 15th October in Medical Research Center, Jazan
University, Jazan, KSA

LECTURER from 16th October till date in College of Pharmacy, Jazan University, Jazan,
KSA
EDUCATION

Ph.D. under the supervision of Prof. Fakhrul Islam, Department of Medical Elementology
and Toxicology, Hamdard University, New Delhi, India on the topic titled “In vitro βamyloid protein toxicated cell culture and in vivo cognitive impairment (Alzheimer’s
Disease) and their prevention”

Master of Science (M.Sc.), 2006 in Toxicology from Jamia Hamdard, New Delhi, India
(81.38%)

Bachelor of Science (B.Sc.), 2004 in Chemistry (Hons.) from Aligarh Muslim University,
Aligarh, U.P. India (75.2%)
SKILLS/CERTIFICATIONS

Best poster award in The Second Medicinal Chemistry seminar (New Delhi) of JSPS AsiaAfrica Science Platform Program on 21-22 Oct 2011.
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Qualified ICMR-SRF in 2011 (Not availed)
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Awarded CSIR-SRF in April 2011
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Qualified UGC-NET (Lecturership) in June 2010
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Junior research fellow (JRF), from Nov-2009 to March 2011 in Maulana Azad Fellowship,
UGC, Ministry of Health & Family Welfare, Govt. of India.
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Junior research fellow (JRF), from Nov-2007 till Oct-2009 in a project funded by the
Department of AYUSH, Ministry of Health & Family Welfare, Govt. of India. (Project
Topic: “Effect of Homeopathic medicines on healthy neuronal cell line”)

GOLD MEDAL for Academic Achievements in M.Sc. (Toxicology) 2006, Jamia Hamdard,
New Delhi.

Hamdard National Foundation Scholarship for merit cum financial basis in 2004, Jamia
Hamdard, New Delhi.
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Tasnima Fellowship for best girl scholar in M.Sc. final, 2005, Jamia Hamdard, New Delhi.
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First Prize for Academic Achievements in M.Sc. (P) 2005, Jamia Hamdard, New Delhi.

Certificate of merit for academic excellence in B.Sc. Chem. (Hons) 2004, Women’s
College A.M.U., Aligarh.

First prize in chart & model making competition held by science society on HEALTH
HAZARDS 2003, Women’s College A.M.U., Aligarh.

Proficient in WordPerfect, Windows MS Word, Excel, Visual Basic, Power Point and
various application programs

Management Skills:
assertiveness training

Strong communications skills as author, teacher, debater
time
management,
communications,
goal
settings
training,
ASSOCIATION/ORGANISATION
Life time membership of Society for Neurochemistry, India (SNCI)
SEMINAR DELEVERED AND CONFERENCE ATTENDED

Poster presentation in “32nd Annual Conference of Society of Toxicology (India) and
International Symposium on new frontiers in Toxicology” from December 5-7, 2012, IITR,
Lucknow, India.

Attended one day Symposium on Principles of Good Laboratory Practices on 4th December
2012 in IITR, Lucknow, India.

Poster presentation in The Second Medicinal Chemistry seminar (New Delhi) of JSPS
Asia-Africa Science Platform Program on 21-22 Oct 2011.

Delivered a university level seminar on “Curcumin protected PC12 cells against betaamyloid-induced toxicity through the inhibition of oxidative damage and tau
hyperphosphorylation” in Department of Toxicology, Jamia Hamdard, New Delhi on 5th
March, 2011.

National Seminar on Role of GCMS, Flash Chromatography and HPTLC in Botanical Drug
Development” on 17th January, 2011 organised by Department of Pharmacognosy and
Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.

Participated and Poster presentation in “30th Annual Conference of Society of Toxicology
(India) and Symposium on Strategies for Safety Study Requirements for Herbal
Formulations” from December 9-11, 2010, Jamia Hamdard, New Delhi, India.

Delivered a university level seminar on “In Vitro β-amyloid Protein Toxicated Cell
Culture And In Vivo Cognitive Impairment (Alzheimer’s Disease) And Their
Prevention” in Department of Toxicology, Jamia Hamdard, New Delhi on 20th March, 2010.

Participated in National Symposium on Epilepsy: Recent Advances in Drug Discovery and
Treatment on February 13, 2010 organized by Department of Pharmacology, Faculty of
Pharmacy, Jamia Hamdard, New Delhi, India.

Participated and Poster presentation in “International Conference on Advances in
Neurosciences and XXIV Annual Conference of Indian Academy of Neuroscience” from
December 12-14, 2008, Cochin University, Cochin, India.

Attended National Seminar on “Biotechnology and Human Welfare” from March 19-20,
2007.

Participated in “International Update on Basic and Clinical Neuroscience advances and
XXIV Annual Conference of Indian Academy of Neurosciences” from December 17-20,
2006, ITRC, Lucknow, India

Attended seminar on “Application of Modern Analytical Techniques in Chemical and
Biological Sciences”.

Attended INDO UK seminar lecture on “Biomarkers of Ecotoxicology, Cancer,
Monitoring & Prevention “on August 29, 2004. Jamia Hamdard (Sponsored by Indian
National Science Academy,U.G.C)

Delivered a university level seminar on “Food Additives in common indian food” under
Dr. Tamanna Jahangir in Department of Toxicology, Jamia Hamdard, New Delhi in 2004.
RESEARCH FIELD OF INTEREST
My research interests focus on the molecular events underlying age related neurodegenerative
diseases. In my studies I concentrate on Alzheimer’s disease (Cognitive impairment) and its
prevention by herbal or nanoformulations. Considerable efforts have been made to determine the
cellular mechanisms that might underlie the cell death in these diseases and neuronal injury.
Over the years, several pathogenic hypotheses have been proposed, including oxidative stress,
apoptosis, excitotoxicity, inflammation and mitochondrial dysfunction. However, still it is not
known which of these metabolic pathways participate in the process of cell death, if and how
they interact and which genes are regulating this complex network. I am also planning to pursue
my future career in dissecting the molecular mechanism of this neurological disorder and to
develop exclusive preventive/treatment therapy both in vitro and in vivo.
RESEARCH TECHNIQUES KNOWN/ EXPERTISE

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
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Neurodegenerative disorders (PD and AD)
Molecular pathogenesis
Apoptosis
Oxidative stress in neuropathogenesis
Neurobehavioral alterations in neurodegeneration
Inflammation
Surgery
Stereotaxic surgery (Induction of Alzheimer disease and Parkinson disease)
Identification and removal of different parts of brain
Biochemical and Neurochemical assays
Oxidative biomarkers
Apoptosis Pathway’s markers
Inflammation Pathway’s markers
Perfusion
Molecular
DNA Isolation and quantification
Expertise in Immunohistochemistry
Histopathology (H&E and CV staining)
Analytical
Spectrophotometer
ELISA reader
Neurobehavioral
Evaluation of cognitive deficits by Morris water maize, elevated plus maize and jumping box
(passive avoidance apparatus) and Cook’s pole.
Motor deficit evaluation by Rota-rod apparatus, Grip test, Video path analyzer and open field
studies.
Cell Culture
Maintaining mammalian cell lines (Adherent and Suspended)
Primary culture of epithelial cells of trachea
Differentiation of PC12 cells
FULL LENGTH PAPERS
1. Khan A, Vaibhav K, Javed H, Tabassum R, Ahmed ME, Khan MM, Khan MB, Srivastava P,
Islam F, Siddiqui M.S., Shafi M.M, Islam F. 2014. 1,8-cineole (eucalyptol) mitigates
inflammation in amyloid beta toxicated PC12 cells: relevance to Alzheimer's disease.
Neurochem. Res. 39(2):344-52.
2. Khan A, Vaibhav K, Javed H, Khan M.M, Tabassum R, Ahmed ME, Srivastava P, Khuwaja
G, Islam F, Siddiqui M.S., Shafi M.M, Islam F. 2012. Attenuation of Aβ-induced
neurotoxicity by thymoquinone via inhibition of mitochondrial dysfunction and oxidative
stress. Mol. Cell. Biochem. 369(1-2):55-65.
3. Khan A, Vaibhav K, Javed H, Khan M.M, Tabassum R, Ahmed ME, Raza SS, Ashafaq M,
Khuwaja G, Gupta V, Deora A.K, Pant A.B, Siddiqui M.S, Islam F. 2011. Neuroprotective
effect of Bellis perennis and Hypericum perforatum on PC 12 cells. Indian journal of
Research in Homeopathy. 5(3):0-44.
4. Khan A, Farah Islam, Gulrana Khuwaja, Tauheed Ishrat, Kumar Vaibhav, Hayat Javed,
Rizwana Tabassum, Md. Ejaz Ahmed, Badaruzaman Khan, Minakshi Das, Fakhrul Islam.
Protective effect of Zincum Metallicum on rat model of Parkinson's disease. 2014. Indian
journal of Research in Homeopathy. (Accepted).
5. Javed H, Vaibhav K, Ahmed ME, Khan A, Tabassum R, Islam F, Safhi MM, Islam F. 2014.
Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid
alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice. J
Neurol Sci. J Neurol Sci. 348(1-2):51-9.
6. Tabassum R, Vaibhav K, Shrivastava P, Khan A, Ahmed ME, Ashafaq M, Khan MB, Islam
F, Safhi MM, Islam F. 2014. Perillyl alcohol improves functional and histological outcomes
against ischemia-reperfusion injury by attenuation of oxidative stress and repression of COX2, NOS-2 and NF-κB in middle cerebral artery occlusion rats. Eur J Pharmacol. Eur J
Pharmacol. 2015 Jan 15;747:190-9.
7. Chander K, Vaibhav K, Ejaz Ahmed M, Javed H, Tabassum R, Khan A, Kumar M, Katyal
A, Islam F, Saeed Siddiqui M. 2014. Quercetin mitigates lead acetate-induced behavioral and
histological alterations via suppression of oxidative stress, Hsp-70, Bak and upregulation of
Bcl-2. Food Chem Toxicol. 68:297-306.
8. Vaibhav K, Shrivastava P, Tabassum R, Khan A, Javed H, Ahmed ME, Islam F, Safhi MM,
Islam F. 2013. Delayed administration of zingerone mitigates the behavioral and histological
alteration via repression of oxidative stress and intrinsic programmed cell death in focal
transient ischemic rats. Pharmacol Biochem Behav. 15;113:53-62.
9. Javed H, Khan A, Vaibhav K, Moshahid Khan M, Ahmad A, Ejaz Ahmad M, Ahmad A,
Tabassum R, Islam F, Safhi MM, Islam F. 2013. Taurine ameliorates neurobehavioral,
neurochemical and immunohistochemical changes in sporadic dementia of Alzheimer's type
(SDAT) caused by intracerebroventricular streptozotocin in rats. Neurol Sci. 34(12):2181-92.
10. Raouf GAM, Vaibhav K, Khan A, Tabassum R, Ahmed ME, Javed H, Chander K, Islam F,
Siddiqui M.S. 2013. Terminalia arjuna bark extract inhibits histological alterations by
mitigating oxidative stress in lead intoxicated mice. Orient Pharm Exp Med. 13:253-265.
11. Ahmed ME, Khan MM, Javed H, Vaibhav K; Khan A, Tabassum R, Ashafaq M, Islam F,
Safhi MM, Islam F. 2013. Amelioration of cognitive impairment and neurodegeneration by
catechin hydrate in rat model of streptozotocin-induced experimental dementia of
Alzheimer's type. Neurochem Int. 62(4):492-501.
12. Ahmed ME, Javed H, Khan MM, Vaibhav K, Ahmad A, Khan A, Tabassum R, Islam
F, Safhi MM, Islam F. 2013. Attenuation of oxidative damage-associated cognitive decline
by Withania somnifera in rat model of streptozotocin-induced cognitive impairment.
Protoplasma. 250(5):1067-78.
13. Vaibhav K, Shrivastava P, Khan A, Javed H, Tabassum R, Ahmed ME, Khan MB,
Moshahid Khan M, Islam F, Ahmad S, Siddiqui MS, Safhi MM, Islam F. 2012. Azadirachta
indica mitigates behavioral impairments, oxidative damage, histological alterations and
apoptosis in focal cerebral ischemia-reperfusion model of rats. Neurol Sci. 34(8):1321-30.
14. Khan M.B, Khan M.M, Khan A, Ahmed ME, Ishrat T, Tabassum R, Vaibhav K, Ahmad A,
Islam F. 2012. Naringenin ameliorates Alzheimer’s disease (AD)-type neurodegeneration
with cognitive impairment (AD-TNDCI) caused by the intracerebroventricular-streptozotocin
in rat model. Neurochem. Int. 61(7):1081-93.
15. Tabassum R, Vaibhav K, Shrivastava P, Khan A, Ahmed ME, Javed H, Islam F, Ahmad S,
Siddiqui MS, Safhi MM, Islam F. 2012. Centella asiatica attenuates the neurobehavioral,
neurochemical and histological changes in transient focal middle cerebral artery occlusion
rats. Neurol Sci. 34(6):925-33.
16. Shrivastava P, Vaibhav K, Tabassum R, Khan A, Ishrat T, Khan MM, Ahmad A, Islam F,
Safhi MM, Islam F. 2012. Anti-apoptotic and Anti-inflammatory effect of Piperine on 6OHDA induced Parkinson's Rat model. J Nutr Biochem. 24(4):680-7.
17. Vaibhav K, Shrivastava P, Khan A, Javed H, Tabassum R, Ahmed ME, Khan MM, Khuwaja
G, Islam F, Ahmad S, Siddiqui MS, Safhi MM, Islam F. 2012. Piperine suppresses cerebral
ischemic reperfusion-induced inflammation through the repression of COX-2, NOS-2 and
NF-<kappa>B in middle cerebral artery occlusion rat model. Mol Cell Biochem. 367(12):73-84.
18. Javed H, Khan MM, Ahmad A, Vaibhav K, Ahmad ME, Khan A, Ashafaq M, Islam
F, Siddiqui MS, Safhi MM, Islam F. 2012. Rutin prevents cognitive impairments by
ameliorating oxidative stress and neuroinflammation in rat model of sporadic dementia of
Alzheimer type. Neuroscience. 210, 340-52.
19. Ashafaq M, Khan M.M, Raza SS, Ahmad A, Khuwaja G, Javed H, Khan A, Siddiqui M.S,
Shafi M.M, Islam F. 2012. S-allyl cysteine mitigates oxidative damage and improves
neurologic deficit in a rat model of focal cerebral ischemia. Nutr Res. 32(2), 133-43.
20. Khan M.M, Raza SS, Javed H, Ahmad A, Khan A, Islam F, Safhi MM, Islam F. 2011. Rutin
Protects Dopaminergic Neurons from Oxidative Stress in an Animal Model of Parkinson's
Disease. Neurotox Res. 22(1), 1-15.
21. Raza SS, Khan MM, Ashafaq M, Ahmad A, Khuwaja G, Khan A, Siddiqui MS, Safhi MM,
Islam F. 2011. Silymarin protects neurons from oxidative stress associated damages in focal
cerebral ischemia: a behavioral, biochemical and immunohistological study in Wistar rats. J
Neurol Sci. 309(1-2), 45-54.
22. Parveen H, Hayat F, Mukhtar S, Salahuddin A, Khan A, Islam F, Azam A. 2011. Synthesis,
characterization and biological evaluation of novel 2,4,6 trisubstituted bis-pyrimidine
derivatives. Eur J Med Chem. 46(9), 4669-75.
23. Javed H, Khan MM, Khan A, Vaibhav K, Ahmad A, Khuwaja G, Ahmed ME, Raza SS,
Ahmad A, Tabassum R, Siddiqui MS, El-Agnaf OM, Safhi MM, Islam F. 2011. S-allyl
cysteine attenuates oxidative stress associated cognitive impairment and neurodegeneration
in mouse model of streptozotocin-induced experimental dementia of Alzheimer's type. Brain
Res. 1389, 133-42.
24. Khuwaja G, Khan MM, Ishrat T, Ahmad A, Raza SS, Ashafaq M, Javed H, Khan MB, Khan
A, Vaibhav K, Safhi MM, Islam F. 2011. Neuroprotective effects of curcumin on 6hydroxydopamine-induced Parkinsonism in rats: Behavioral, neurochemical and
immunohistochemical studies. Brain Res. 1368, 254-63.
25. Khan MM, Ahmad A, Ishrat T, Badruzzaman M, Hoda N, Raza SS, Khan A, Khuwaja G,
Javed H, Vaibhav K, Islam F. 2010. Resveratrol attenuates 6-hydroxydopamine-induced
oxidative damage and dopamine depletion in rat model of Parkinson's disease. Brain Res.
1328, 139-51.
26. Khan MM, Ahmad A, Ishrat T, Khuwaja G, Srivastawa P, Khan MB, Raza SS, Javed H,
Vaibhav K, Khan A, Islam F. 2009. Rutin protects the neural damage induced by transient
focal ischemia in rats. Brain Res. 1292, 123-35.
PERSONAL DETAILS
Husband’s Name
Date of Birth
Nationality
Marital Status
Language known
:
:
:
:
:
Dr. Syed Wajahat Ali
2 April 1983
Indian
Married
English, Hindi and Urdu
DECLARATION
I declare that the information furnished above is true and authentic to the best of knowledge and
belief.
Date: March 2015
Place: Jazan
ANDLEEB KHAN