Date of revision: January 27, 2016
CURRICULUM VITAE
Andrei K. Yudin, Ph.D., FRSC (UK), FRSC (Canada)
A. BIOGRAPHICAL INFORMATION
1. Personal
University Address:
Department of Chemistry
University of Toronto
80 St. George St.
Toronto, Ontario M5S 3H6
Tel: (416) 946-5042
Fax: (416) 946-7676
E-mail: ayudin@chem.utoronto.ca,
Blog: http://www.amphoteros.com
Group website: http://www.chem.utoronto.ca/staff/YUDIN/yudinsgroup.html
2. Education
1996
Ph.D. in Chemistry
University of Southern California (Los Angeles, California)
Graduate thesis: “From Nucleophilic Perfluoroalkylations to Electrophilic
Intermediates”
Advisors: Professors G. K. S. Prakash and G. A. Olah
1992
B.S. in Chemistry (Honors)
Moscow State University (Moscow, Russia)
Advisor: Professor N. S. Zefirov
3. Employment
2014
Chair of the Board, Organic and Biomolecular Chemistry (Royal Society of
Chemistry, UK)
2012-2014
Associate Editor, Organic and Biomolecular Chemistry (Royal Society of
Chemistry, UK)
2006
Early Promotion to the rank of Full Professor
2002-2006
Associate Professor, Chemistry Department
1
2002
Early tenure promotion to the rank of Associate Professor
2002
Appointed to School of Graduate Studies, University of Toronto
1998-2002
Assistant Professor, Chemistry Department
1996-1998
Postdoctoral Fellow, The Scripps Research Institute
Advisor: Professor K. Barry Sharpless
4. Honors and awards
2015 Bernard Belleau Award (CSC);
2013 Admitted as a Fellow to the Royal Society (Canada);
2012 Admitted as a Fellow to the Royal Society of Chemistry (UK);
2011 Inventor of the Year (University of Toronto);
2010 Royal Society of Canada Rutherford Memorial Medal;
2010 CSC Merck-Frosst Center for Therapeutic Research Award;
2008 NSERC Discovery Accelerator Award;
2008 Tokyo Institute of Technology Global Edge Fellowship;
2007 Full Professor (early promotion);
2005 American Chemical Society Moissant Fellowship (together with Dr. Neil Vasdev);
2004 Amgen New Faculty Award;
2004 Merck, Sharpe & Dome lectureship (UK);
2003 Ichikizaki Fund Travel Award;
2002 Ichikizaki Fund Travel Award;
2001 Cottrell Scholar Award (Research Corporation);
2000 Premier's Research Excellence Award;
2000 Gordon Research Conference in Organometallic Chemistry poster selection for an oral
presentation;
2000 Canadian Society of Chemistry Award for Combinatorial Chemistry;
2000 Ichikizaki Fund Travel Award;
1999 Ichikizaki Fund Travel Award;
1998 Research Innovation Award (Research Corporation);
1998 Canada Foundation for Innovation Researcher.
5. Professional Affiliations and Activities
CIHR – CHRP grant panel 2016;
Co-organizer, 24th American Peptide Society Meeting in Orlando, Florida (June 2015);
Sabbatical, The Structural Genomics Consortium (July-December 2013);
CQDM Program with Quebec (University of Sherbrooke);
Council member, American Peptide Society (elected in 2013);
Chair of the Board, Organic and Biomolecular Chemistry (RSC);
Guest Editor, Chemical Reviews (special issue on “Small Ring Heterocycles”);
Founder, Encycle Therapeutics (www.encyclethrapeutics.com);
Founder, Ylektra;
Professional society memberships: American Chemical Society, Canadian Society for Chemistry,
Electrochemical Society; Royal Society for Chemistry;
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Member, executive Committee of the Organic and Biological Electrochemistry Division of the
Electrochemical Society;
Symposia organization: American Peptide Symposium (Orkando, Florida, 2015); Symposium on
Mechanistic Aspects of Organic Electrochemistry (Quebec City, 2005); Organic Electrosynthesis
(ESC meeting, Chicago, 2007); QOMSBOC 2008 (Quebec-Ontario Minisymposium in Synthetic
and Biological Chemistry);
Consulting: Ensemble Therapeutics (Boston, MA); Applied Biosystems (San Francisco, CA),
Affinium Pharmaceuticals (Toronto, Ontario), Schering-Plough (Clark, NJ), DexCom (San
Diego, CA), Ylektra (Toronto, Ontario), Encycle Therapeutics (Toronto, Canada), Dainippon
Pharma (Osaka, Japan).
B. ACADEMIC HISTORY
6. a. Research Interests
- organic synthesis
- peptide chemistry
- asymmetric catalysis
- synthetic methodology
- macrocycles
- multicomponent reactions
- transition metal catalysis
- chemical biology
- medicinal chemistry
b. Patents (issued and in progress)
Yudin, A. K.; Zajdlik, A. “Boron-containing isocyanides” PCT Application 2014 (61/807,
400);
Yudin, A. K.; White, C. J. “Amino acid-based reagents for peptide macrocyclization”
Provisional Application 2010 (61349864);
Yudin, A. K.; Rai, V.; Hili, R. “A method to insert molecular fragments into cyclic molecules”
Provisional Application 2010 (61349922);
Hili, R. and Yudin, A. K. “Cyclic amino acid molecules and methods of preparing the same”
Provisional Application 2010 (PCT/CA2010/000408);
Hili, R. and Yudin, A. K. “Unprotected amino aldehydes and uses thereof” WO/2008/046232;
Yudin, A. K. “New P,N Ligands for Asymmetric Catalysis,” 60/369,810 2002;
Yudin, A. K.; Siu, T. “Nitrogen Atom Transfer,” PCT 3110/0016 2002;
Sharpless, K. B.; Yudin, A. K. “Epoxidation of Olefins,” US6271400 2001;
Yudin, A. K.; Siu, T.; Li, W. “The SAEP Platform,” CA01/00832l 2000;
Yudin, A. K.; Martyn, L. J. P.; Pandiaraju, S. “Polyfluorinated Catalysts,” 60/144,812 1999;
Yudin, A. K. “Process for Screening of Electrocatalysts,” 60/083,605 1998.
C. SCHOLARLY AND PROFESSIONAL WORK
7. Refereed publications
a. Articles
130. Yudin, A. K. “Nature’s Enzymes Tricked with Xenobiotic Oxidants,” ACS Central
Sci. 2015, 1, 62-63.
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129. St. Denis, J. D.; Lee, C. F.; Yudin, A. K. “Access to Cyclic Amino Boronates via
Rhodium-Catalyzed Functionalization of Alkyl MIDA Boronates,” Org. Lett., 2015, 17,
5764-5767.
128. Adachi, S.; Liew, S. K.; Lee, C. F.; Lough, A.; He, Z.; St. Denis, J. D.; Poda, G.;
Yudin, A. K. “Condensation-Driven Assembly of Boron-Containing Bis(Heteroaryl)
Motifs Using a Linchpin Approach,” Org. Lett., 2015, 17, 5594-5597.
127. St. Denis, J. D.; He, Z.; Yudin, A. K. “Amphoteric α-Boryl Aldehyde Linchpins in
the Synthesis of Heterocycles,” ACS Catal. 2015, 5, 5373-5379.
126. Zaretsky, S.; Hickey, J. L.; Tan, J.; Pichugin, D.; St. Denis, M. A.; Ler, S.; Chung,
B. K. W.; Scully, C. C. G. “Mechanistic investigation of aziridine aldehyde-driven
peptide macrocyclization: The imidoanhydride pathway,” Chem. Sci. 2015, 6, 5446-5455.
125. Trinchera, P; Corless, V. B.; Yudin, A. K. “Synthesis of Previously Inaccessible
Borylated Heterocycle Motifs Using Novel Boron-Containing Amphoteric Molecules
,”
Angew. Chem. Int. Ed. 2015, 54, 9038-9041.
124. Chung, B. K. W.; Yudin, A. K. “Disulfide-bridged peptide macrobicycles from
nature Org. Biomol. Chem. 2015, 13, 8768-8779.
123. Zaretsky, S.; Rai, V.; Gish, G.; Forbes, M. W.; Kofler, M.; Yu, J. C. Y.; Tan, J.;
Hickey, J. L.; Pawson, T.; Yudin, A. K. “Twisted amide electrophiles enable cyclic
peptide sequencing,” Org. Biomol. Chem. 2015, 13, 7384-7388.
122. Treder, A. P.; Hickey, J. L.; Tremblay, M. -C. J.; Zaretsky, S.; Scully, C. C. G.;
Mancuso, J.; Yudin, A. K.; Marsault, E. “Solid-phase parallel synthesis of functionalised
medium-to-large cyclic peptidomimetics through three-component coupling driven by
aziridine aldehyde dimers,” Chem. Eur. J. 2015, 21, 9249-9255.
121. Adachi, S.; Cognetta, A. B., III; Niphakis, M. J.; He, Z.; Zajdlik, A.; St. Denis, J. D.;
Scully, C. C. G.; Cravatt, B. F.; Yudin, A. K. “Facile profiling of borofragments and their
evaluation in activity-based protein profiling,” Chem. Commun. 2015, 51, 3608-3611.
120. Zaretsky, S.; Tan, J.; Tan, J.; Hickey, J. L.; Yudin, A. K. “Macrocyclic templates for
library synthesis of peptido-conjugates,” Meth. Mol. Biol. 2015, 1248, 67-80.
119. St. Denis, J. D.; Zajdlik, A.; Tan, J.; Trinchera, P.; Lee, C. F.; He, Z.; Adachi, S.;
Yudin, A. K. “Boron-containing enamine and enamide linchpins in the synthesis of
nitrogen heterocycles,” J. Am. Chem. Soc. 2014, 136, 17669-17673.
118. Zaretsky, S.; Adachi, S.; Rotstein, B. H.; Hickey, J. L.; Scully, C. C. G.; St. Denis, J.
D.; Courtemanche, R.; Yu, J. C. Y.; Chung, B. K. W.; Yudin, A. K. “Stereocontrolled
disruption of the Ugi reaction toward the production of chiral piperazinones: Substrate
scope and process development,” J. Org. Chem. 2014, 79, 9948-9957. (Feature article)
117. Treder, A.P., Tremblay, M.-C., Yudin, A.K., Marsault, E. “Solid-phase synthesis of
piperazinones via disrupted Ugi condensation,” Org. Lett. 2014, 16, 4674-4677.
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116. Belding, L., Zaretsky, S., Rotstein, B. H., Yudin, A. K., Dudding, T. “Shifting the
energy landscape of multicomponent reactions using aziridine aldehyde dimers: A
mechanistic study,” J. Org. Chem. 2014, 79, 9465-9471.
115. Yudin, A. K. “Macrocycles: Lessons from the Distant Past, Recent Developments,
and Future Directions,” Chem. Sci., 2015, 6, 30-49.
114. He, Z.; Zajdlik, A.; Yudin, A. K. “alpha-Borylcarbonyl Compounds: from Transient
Intermediates to Robust Building Blocks,” Dalton Trans. 2014, 43, 11434-11451.
113. Zaretsky, S.; Hickey, J. L.; St. Denis, M. A.; Scully, C. C. G.; Roughton, A. L.;
Tantillo, D. J.; Lodewyk, M. W.; Yudin, A. K. “Predicting Cyclic Peptide Chemical
Shifts using Quantum Mechanical Calculations,” Tetrahedron 2014, 70, 7655-7663.
112. Rotstein, B.; Zaretsky, S.; Rai, V.; Yudin, A. K. “Small Ring Heterocycles in
Multicomponent Reactions,” Chem. Rev. 2014, 114, 8323-8359.
111. White, C. J.; Scully, C. G.; Hickey, J. L.; Yudin, A. K. “Site-specific integration of
molecular fragments into cyclic peptides,” J. Am. Chem. Soc. 2014, 136, 3728-3731.
110. St. Denis, J. D.; Scully, C. C. G.; Lee, C. F.; Yudin, A. K. “Development of the
direct Suzuki-Miyaura cross-coupling of primary B-alkyl MIDA-boronates and aryl
bromides,” Org. Lett. 2014, 16, 1338-1341.
109. Chen, G.; He, Z.; Yudin, A. K. “Synthesis of functionalized 1azabicyclo[3.1.0]hexanes: studies towards ficellomycin and its analogs,” Heterocycles
2014, 88, 1299-1310.
108. He, Z.; Zajdlik, A.; Yudin, A. K. “Air- and moisture-stable amphoteric molecules:
enabling reagents in synthesis,” Acc. Chem. Res. 2014, 47, 1029-1040.
107. Zaretsky, S; Scully, C. C. G.; Yudin, A. K. "Exocyclic control of turn induction in
macrocyclic peptide scaffolds,” Chem. Eur. J. 2013, 19, 17668-17672.
106. (Journal cover) Liew, S. K.; He, Z.; St. Denis, J. D.; Yudin, A. K. "Stereocontrolled
Synthesis of 1,2- and 1,3-Diamine Building Blocks from Aziridine Aldehyde Dimers,” J.
Org. Chem. 2013, 78, 11637-11645.
105. Zajdlik, A.; Hickey, J.; Zhou, Z.; Schimmer, A.; Yudin, A. K. “Boryl isocyanides –
reagents for facile preparation of bioactive boropeptides,” Angew. Chem. Int. Ed. 2013,
52, 8411-8415.
104. Chung, B.; Hickey, J.; Zaretsky, S; Scully, C.; Yudin, A. K. “Bicycle Synthesis
Through Peptide Macrocyclization Using Aziridine Aldehydes Followed by Late Stage
Disulfide Bond Installation,” Med. Chem. Comm. 2013, 4, 1124-1128.
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103. Dubovyk, I.; Watson, I. D. G.; Yudin, A. K. “Achieving control over the
branched/linear selectivity in palladium-catalyzed allylic amination,” J. Org. Chem. 2013,
78, 1559-1575.
102. He, Z.; Dobrovolsky, D.; Trinchera, P.; Yudin, A. K. “Synthesis of multisubstituted
pyridines,” Org. Lett. 2013, 15, 334-337.
101. He, Z.; Trinchera, P.; Adachi, S.; St. Denis, J. D.; Yudin, A. K. “Geminal oxidative
functionalization of organoboron compounds,” Angew. Chem. Int. Ed. 2012, 51, 1109211096.
100. Scully, C. C. G.; Rai, V.; Poda, G.; Zaretsky, S.; Burns, D. C.; Houliston, S. R.; Lou,
T.; Yudin, A. K. “Bending rigid molecular rods: formation of oligoproline macrocycles,”
Chem. Eur. J. 2012, 18, 15612-15617.
99. St. Denis, J. D.; He, Z.; Yudin, A. K. “Chemoselective palladium-catalyzed αallylation of α-boryl aldehydes,” Org. Biomol. Chem. 2012, 10, 7900-7902.
98. Jebrail, M. J.; Assem, N.; Mudrik, J. M.; Dryden, M. D. M., Lin, K.; Yudin, A. K.
Wheeler, A. R. “Combinatorial Synthesis of Peptidomimetics Using Digital
Microfluidics,” J. Flow Chem. 2012, 2, 103-107.
97. He, Z.; Zajdlik, A.; St. Denis, J.; Assem, N.; Yudin, A. K. “Boroalkyl group
migration provides a versatile entry into alpha-amino boronic acid derivatives” J. Am.
Chem. Soc. 2012, 134, 9926-9929.
96. Roxin, A.; Chen, J.; Scully, C.; Rotstein, B. H.; Yudin, A. K.; Zheng, G.
“Conformational modulation of in vitro activity of cyclic RGD peptides via aziridine
aldehyde-driven macrocyclization chemistry” Bioconj. Chem. 2012, 23, 1387-1395.
95. Assem, N.; Hili, R.; He, Z.; Kasahara, T.; Inman, B.; Decker, S.; Yudin, A. K. “The
role of reversible dimerization in reactions of amphoteric aziridine aldehydes,” J. Org.
Chem. 2012, 77, 5613-5623.
94. White, C. J. and Yudin, A. K. “A versatile scaffold for site-specific modification of
cyclic tetrapeptides,” Org. Lett. 2012, 14, 2898-2901.
93. Assem, N. and Yudin, A. K. “Convergent Synthesis of Peptidomimetics,” Nature
Prot. 2012, 7, 1327-1334.
92. Yudin, A. K. “Synthesis of Heterocycles using Amphoteric Reagents,” Chem. Het.
Comp. 2012, 48, 191-199;
91. Rotstein, B. H.; Winternheimer, D. J.; Yin, L. M.; Deber, C. M.; Yudin, A. K.
“Thioester-isocyanides: Versatile reagents for the synthesis of cycle-tail peptides,” Chem.
Comm. 2012, 48, 3775-3777.
90. He, Z; Yudin, A. K. “Amphoteric alpha-Boryl Aldehydes,” J. Am. Chem. Soc. 2011,
133, 13770-13773.
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89. Prakash, G. K. S.; Wang, F.; Ni, C.; Shen, J.; Haiges, R.; Yudin, A. K.; Mathew, T.;
Olah, G. A. “Conformational Study of 9-dehydro-9-trifluoromethyl cinchona alkaloids
via 19F NMR spectroscopy: Emergence of Trifluoromethyl Moiety as a Conformational
Stabilizer and a Probe,” J. Am. Chem. Soc. 2011, 133, 9991-9995.
88. Rotstein, B. H.; Mourtada, R.; Kelley, S. O.; Yudin, A. K. “Solvatochromic Reagents
for Multicomponent Reactions and their Utility in the Development of Cell-Permeable
Macrocyclic Peptide Vectors,” Chem. Eur. J. 2011, 44, 12257-12261.
87. Cheung, L.; He, Z.; Decker, S.; Yudin, A. K. “Skeletal Fusion of Small Heterocycles
with Amphoteric Molecules,” Angew. Chem. Int. Ed. 2011, 49, 11798-11802.
86. Dubovyk, I. D.; Pichugin, D.; Yudin, A. K. “Palladium-Catalyzed Ring Contraction
and Ring Expansion Reactions of Cyclic Allyl Amines,” Angew. Chem. Int. Ed. 2011, 50,
5924-5926.
85. White, C. J.; Yudin, A. K. “Contemporary Strategies for Peptide Macrocyclization,”
Nature Chem. 2011, 3, 509-524.
84. Siebert, M. R.; Yudin, A. K.; Tantillo, D. J. “The effect of strain on the RhI-catalyzed
rearrangement of allylamines” Eur. J. Org. Chem. 2011, 3, 553-561.
83. (Journal Covert Art) Jebrail, M. J.; Ng, A. H. C.; Rai, V.; Yudin, A. K.; Wheeler, A.
R. “Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics,”
Angew. Chem. Int. Ed. 2010, 49, 8625-8629.
82. Rotstein, B.; Rai, V.; Hili, R.; Yudin, A. K. “Synthesis of Cyclic Peptides Using
Amphoteric Amino Aldehydes,” Nature Prot. 2010, 5, 1813.
81. Simms, R.; Dubinsky, S.; Yudin, A.; Kumacheva, E. “A method for fabricating
microfluidic electrochemical reactors,” Lab Chip 2009, 9, 2395-2397.
80. Watson, I. D. G.; Afagh, N.; Yudin, A.K.; Troendlin, L.; Pfaltz, A “Cyclohexene
imine (7-Aza-bicyclo[4.1.0] heptane),” Organic Syntheses, 2010, 87 , 161-169
79. Assem, N.; Natarajan, A.; Yudin, A. K. “Chemoselective Peptidomimetic Ligation
using Thioacid Peptides and Aziridine Templates,” J. Am. Chem. Soc. 2010, 132, 1098610987.
78. Hili, R.; Rai, V.; Yudin, A. K. “Macrocyclization of Linear Peptides Enabled by
Amphoteric Molecules,” J. Am. Chem. Soc. 2010, 132, 2889-2891.
77. Cheung, L.; Yudin, A. K. “Synthesis of Highly Substituted Cyclobutane Fused-Ring
Systems from N-Vinyl beta-Lactams through a One-Pot Domino Process,” Chem. Eur. J.
2010, 16, 4100-4109.
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76. He, Z.; Yudin, A. K. “A Versatile Synthetic Platform Based on Strained Propargyl
Amines,” Angew. Chem. Int. Ed. 2010, 49, 1607-1610.
75. Afagh, N. A.; Yudin, A. K. “Chemoselectivity and the Curious Reactivity Preferences
of Functional Groups,” Angew. Chem. Int. Ed. 2010, 49, 262-310. [One of their top 20
downloaded papers]
74. Baktharaman, S.; Afagh, N. A.; Vandersteen, A. “Unprotected Vinyl Aziridines:
Facile Synthesis and Cascade Transformations,” Org. Lett. 2010, 12, 240-243.
73. van Oosten, E.; Chio, J.; Wilson, A. A.; Yudin, A. K.; Houle, S.; Vasdev, N.
“Radiosynthesisof an [18F]-Fluoro-PEG Derivative of TZTP as a Potential Tracer for the
Muscarenic M4 Receptor,” J. Label. Comp. Radiopharm. 2009, 52, S179.
72. Hili, R.; Yudin, A. K. “Amphoteric Amino Aldehydes Reroute the aza-Michael
Reaction,” J. Am. Chem. Soc. 2009, 131, 16404-16406.
71. Cheung, L.; Yudin, A. K. “Synthesis of aminocyclobutanes through ring expansion of
N-vinyl-beta-lactams,” Org. Lett. 2009, 11, 1281-1284.
70. van Oosten, E. M.; Wilson, A. A.; Stephenson, K. A.; Mamo, D. C.; Pollock, B. G.;
Mulsant, B. H.; Yudin, A. K.; Houle, S.; Vasdev, N. “An improved radiosynthesis of the
muscarinic M2 radiopharmaceutical, [18F] FP-TZTP,” Applied Radiation and Isotopes,
2009, 67, 611.
69. Vasdev, N.; van Oosten, E. M.; Stephenson, K. A.; Zadikian, N.; Yudin, A. K.;
Lough, A. J.; Houle, S.; Wilson, A. A. “[18F] Fluoroamines via ring-opening of N-Cbz-2methylaziridine with [18F]-fluoride,” Tetrahedron Lett. 2009, 50, 544-547.
68. Zimmer-De Iuliis, M.; Watson, I. D. G., Yudin, A. K., Morris, R. H. “A DFT
investigation into the origin of regioselectivity in palladium-catalyzed allylic amination,”
Can. J. Chem. 2009, 87, 54-62.
67. Baktharaman, S.; Hili, R.; Yudin, A. K. “Aminocarbonyl compounds in organic
synthesis,” Aldrichim. Acta 2008, 41, 109-118.
66. (Journal Covert Art) Hili, R.; Baktharaman, S.; Yudin, A. K. “Synthesis of chiral
amines using α-amino aldehydes,” Eur. J. Org. Chem. 2008, 5201-5213.
65. Rasmusson, T.; Martyn, L. J. P.; Chen, G.; Lough, A.; Oh, M.; Yudin, A. K.
“Aromatic Fluorine: a Versatile Control Element for the Construction of Molecules with
Helical Chirality” Angew. Chem. Int. Ed. 2008, 47, 7009-7012.
64. Hili, R.; Yudin, A. K. “Amphoteric Amino Aldehydes Enable Rapid Assembly of
Unprotected Amino Alcohols” Angew. Chem. Int. Ed. 2008, 47, 4188-4191.
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63. Siebert, M. R.; Yudin, A. K.; Tantillo, D. J. “Cycloaddition/ring opening reaction
sequences of N-alkenyl aziridines: Influence of the aziridine nitrogen on
stereoselectivity,” Org. Lett. 2008, 10, 57-60.
62. Li, X.; Yudin, A. K. “Epimerization- and protecting group-free synthesis of
peptidomimetic conjugates from amphoteric amino aldehydes” J. Am. Chem. Soc. 2007,
129, 14152-14153.
61. Tsang, D. S.; Yang, S.; Alphonse, F. –A.; Yudin, A. K. “Stereoselective
Isomerization of N-Allyl Aziridines into Geometrically Stable Z Enamines Using
Rhodium Hydride Catalysis” Chem. Eur. J. 2008, 14, 886-894.
60. Dubovyk, I.; Watson, I. D. G.; Yudin, A. K. “Chasing the proton culprit from
palladium-catalyzed allylic amination,” J. Am. Chem. Soc. 2007, 129, 14172-14173.
59. Yang, X.; Yudin, A. K. “Facile generation and synthetic utility of nitrogen-centered
aziridinyl radicals,” Synlett 2007, 18, 2912-2912.
58. Chen, G.; He, Z.; Yudin, A. K. “Synthesis of functionalized 1azabicyclo[3.1.0]hexanes: studies towards ficellomycin and its analogs,” Org. Lett. 2007,
in press.
57. Yekta, S.; Cheung, L.; Yudin, A. K. “Polyfluorinated phosphine ligands in the room
temperature Suzuki cross-coupling reactions,” Tetrahedron Lett. 2007, 48, 8048-8051.
56. Blyumin, E. V.; Gallon, H.; Yudin, A. K. “Construction of three contiguous
stereocenters from aziridines in one step,” Org. Lett. 2007, 9, 4677-4680.
55. Hili, R.; Yudin, A. K. “Overcoming the demons of protecting groups with amphoteric
molecules,” Chem. Eur. J. 2007, 13, 6538-6542.
54. Yu, L.; Kokai, A.; Yudin, A. K. “Preparation and reactivity of versatile α-amino
ketones,” J. Org. Chem. 2007, 72, 1737-1742.
53. Hili, R. and Yudin, A. K. “Readily available unprotected amino aldehydes,” J. Am.
Chem. Soc. 2006, 128, 14772-14773.
52. He, Z. and Yudin, A. K. “Palladium-Catalyzed Oxidative Activation of
Cyclopropanes,” Org. Lett. 2006, 8, 5829-5832.
51. Alphonse, F. -A. and Yudin, A. K. “Rhodium-catalyzed stereoselective formation
of Z- enamines from allyl aziridines,” J. Am. Chem. Soc. 2006, 128, 11754-11755.
50. Chen, G.; Sasaki, M.; Li, X.; Yudin, A. K. “Strained enamines as versatile
intermediates for stereocontrolled construction of nitrogen heterocycles,” J. Org. Chem.
2006, 71, 6067-6073.
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49. Hili, R. and Yudin, A. K. “Making carbon-nitrogen bonds in biological and chemical
synthesis,” Nature Chem. Biol. 2006, 2, 284-287.
48. Krasnova, L. B.; Yudin, A. K. “Highly Regioselective transformation of alkenyl
bromides into α-bromoaziridines and α-bromohydrazones,” Org. Lett. 2006, 8, 20112014.
47. Chen, G.; Sasaki, M.; Yudin, A. K. “Facile preparation of allyl amines and pyrazoles
by hydrazinolysis of 2-ketoaziridines,” Tetrahedron Lett. 2006, 47, 255-259.
46. Watson, I. D. G.; Yu, L.; and Yudin, A. K. “Advances in nitrogen transfer reactions
using aziridines” Acc. Chem. Res. 2006, 39, 194-206. 8th most accessed article and one
of top 20 most cited articles for 2006.
45. Chen, G.; Sasaki, M.; Yudin, A. K. “Facile preparation of allyl amines and pyrazoles
by hydrazinolysis of 2-ketoaziridines,” Tetrahedron Lett. 2006, 47, 255-259.
44. Watson, I. D. G. and Yudin, A. K. “New insights into the mechanism of palladiumcatalyzed allylic amination,” J. Am. Chem. Soc. 2005, 127, 17516-17529.
43. Krasnova, L. B. and Yudin, A. K. “Novel nitrogen containing chelating ligands from
aziridines — Preparation, coordination studies, and catalytic application in the
cyclopropanation of styrene” Can. J. Chem. 2005, 83, 1025-1032.
42. Dalili, S.; Yudin, A. K. “Transition Metal-catalyzed synthesis and reactivity of Nalkenyl aziridines,” Org. Lett. 2005, 7, 1161-1164.
41. Siu, T.; Picard, C.; Yudin, A. K. “Development of electrochemical processes for
nitrene generation and transfer,” J. Org. Chem. 2005, 70, 932-937.
40. Krasnova, L. B.; Hili, R. M.; Chernoloz, O. V.; Yudin, A. K. “Phenyliodine(III)
diacetate as a mild oxidant for aziridination of olefins and imination of sulfoxides with
N-aminophthalimide,” Arkivoc 2005, 4, 26-38.
39. Sasaki, M. and Yudin, A. K. “One-pot reduction-aldol reaction of esters,” Synlett,
2004, 2443-2444.
38. Dalili, S.; Caiazzo, A.; Yudin, A. K. “Aziridine-derived iminophospine ligands in
palladium-catalyzed allylic substitution,” J. Organomet. Chem. 2004, 689, 3604-3611.
37. Yekta, S.; Krasnova, L. B.; Mariampillai, B.; Picard, C. J.; Chen, G.; Pandiaraju, S.;
Yudin, A. K. “Preparation and catalytic application of partially fluorinated binaphthol
ligands,” J. Fluorine. Chem. 2004, 125, 517-525.
36. Watson, I. D. G.; Styler, S. A.; Yudin, A. K. “Unusual selectivity of unprotected
aziridines in palladium-catalyzed allylic amination enables facile preparation of branched
aziridines,” J. Am. Chem. Soc. 2004, 126, 5086-5087.
10
35. Caiazzo, A.; Dalili, S.; Picard, C.; Sasaki, M.; Siu, T.; Yudin, A. K. “New methods
for the synthesis of heterocyclic compounds,” Pure Appl. Chem. 2004, 105, 603-613.
34. Krasnova, L. B.; Yudin, A. K. “Tolylsulfinyl amides as reagents for facile
functionalization of olefins,” J. Org. Chem. 2004, 105, 2584-2587.
33. Sasaki, M; Yudin, A. K. “Oxidative cycloamination of olefins with aziridines as a
versatile route to saturated nitrogen-containing heterocycles,” J. Am. Chem. Soc. 2003,
125, 14242-14243.
32. Caiazzo, A.; Dalili, S.; Yudin, A. K. “Lewis acid-catalyzed dimerization of Nunprotected aziridines,” Synlett 2003, 14, 2198-2202.
31. Chen, Y.; Yekta, S.; Yudin, A. K. “Modified BINOL ligands in asymmetric
catalysis,” Chem. Rev. 2003, 103, 3155 - 3212.
30. Watson, I. D. G.; Yudin, A. K. “Selective functionalization of small organic
molecules using electophilic nitrogen sources,” Current Opinion in Drug Discovery and
Development 2002, 5, 906-917.
29. Chen, Y. and Yudin, A. K. “Synthesis of 3-aminoaspartic acid derivatives from
glycine precursors,” Tetrahedron Lett. 2003, 44, 4865-4868.
28. Watson, I. D. G.; Yudin, A. K. “Ring-opening reactions of nonactivated aziridines
catalyzed by tris(pentafluorophenyl)borane,” J. Org. Chem. 2003, 68, 5160-5167.
27. Sasaki, M.; Dalili, S. “N-Arylation of aziridines,” J. Org. Chem. 2003, 68, 2045-2047.
26. Caiazzo, A.; Lough, A.; Yudin, A. K. “[(R,R)-1-(N-Benzylideneamino)-2(diphenylphosphino)cyclohexane-κ 2 N,P]dichloro(triphenylphosphine-κ
P)ruthenium(II),” Acta Cryst. 2003, E59, m399-m401.
25. Caiazzo, A.; Dalili, S.; Yudin, A. K. “Design and development of cyclohexane-based
P,N-ligands for asymmetric catalysis,” Org. Lett. 2002, 4, 2597-2600.
24. Siu, T. and Yudin, A. K. “Electrochemical imination of sulfoxides using Naminophthalimide,” Org. Lett. 2002, 4, 1839-1842.
23. Siu, T. and Yudin, A. K. “Practical electrochemical olefin aziridination with a broad
substrate scope,” J. Am. Chem. Soc. 2002, 124, 530-531.
22. Pandiaraju, S.; Lough, A.; Yudin, A. K. “Toward new coordination environments and
molecular architectures using F8BINOL, an electron-poor isostere of BINOL,” Isr. J.
Chem. 2002, 41, 309-312.
21. Siu, T.; Li, W.; Yudin, A. K. “ Parallel electrosynthesis of 1,2-diamines,” J. Comb.
Chem. 2001, 554-558.
11
20. Pandiaraju, S.; Chen, G.; Lough, A.; Yudin, A. K. “Generation of highly
enantioselective catalysts from the pseudoenatiomeric assembly of BINOL, F8BINOL,
and Ti(OiPr)4,” J. Am. Chem. Soc. 2001, 123, 3850-3851.
19. Yudin, A. K.; Adolfsson, H.; Chiang, J. P.; Christophe Copéret, C. “Olefin
epoxidation with bis(trimethylsilyl) peroxide catalyzed by inorganic oxorhenium
derivatives. Controlled release of hydrogen peroxide,” J. Org. Chem. 2001, 66, 47134718.
18. Yudin, A. K.; Siu, T. “Combinatorial electrochemistry,” Curr. Opin. Chem. Biol.
2001, 5, 269-272.
17. Adolfsson, H.; Copéret, C.; Chiang, J. P.; Yudin, A. K. “Efficient epoxidation of
alkenes with aqueous hydrogen peroxide catalyzed by methyltrioxorhenium and 3cyanopyridine,” J. Org. Chem. 2000, 65, 8651-8658.
16. Siu, T.; Yekta, S.; Yudin, A. K. “New approach toward rapid generation and
screening of diverse catalytic materials on electrode surfaces,” J. Am. Chem. Soc. 2000,
122, 11787-11790.
15. Chen, Y; Yekta, S.; Martyn, L. J. P.; Zheng, J.; Yudin, A. K. “Regioselective
substitution of fluorine in F8BINOL as a versatile route to new ligands with axial
chirality,” Org. Lett. 2000, 2, 3433-3436.
14. Siu, T.; Li, W.; Yudin, A. K. “Parallel electrosynthesis of α-alkoxycarbamates, αalkoxyamides, and α-alkoxysulfonamides using the spatially addressable electrolysis
platform (SAEP),” J. Comb. Chem. 2000, 2, 545-549.
13. Martyn, L. J. P.; Pandiaraju, S.; Yudin, A. K. “Catalytic applications of F8BINOL.
Enantioselective oxidation of sulfides to sulfoxides,” J. Organomet. Chem. 2000, 603,
98-104.
12. Yudin, A. K.; Martyn, L. J. P.; Pandiaraju, S.; Zheng, J.; Lough, A. “F8BINOL, an
electronically perturbed version of BINOL with remarkable configurational stability,”
Org. Lett. 2000, 2, 41-44.
11. Copéret, C.; Adolfsson, H.; Chiang, J. P.; Yudin, A. K.; Sharpless, K. B. "A simple
and efficient method for the preparation of pyridine-N-oxides II," J. Org. Chem. 1998, 63,
1740-1741.
10. Copéret, C.; Adolfsson, H.; Khuong, T.- A. V.; Yudin, A. K.; Sharpless, K. B. "A
simple and efficient method for the preparation of pyridine-N-oxides," Tetrahedron Lett.
1998, 39, 761-764.
9. Yudin, A. K.; Sharpless, K. B. "Bis(trimethylsilyl) peroxide extends the range of
oxorhenium catalysts for olefin epoxidation," J. Am. Chem. Soc. 1997, 119, 11536-11537.
12
8. Prakash, G. K. S.; Yudin, A. K. "Perfluoroalkylation with organosilicon reagents,"
Chem. Rev. 1997, 97, 757-786.
7. Petasis, N. A.; Yudin, A. K.; Zavialov, I. A.; Prakash, G. K. S.; Olah, G. A. "Facile
preparation of fluorine-containing alkenes, amides, and alcohols via the electrophilic
fluorination of alkenyl boronic Acids and trifluoroborates," Synlett 1997, 606-608.
6. Yudin, A. K.; Prakash, G. K. S.; Deffieux, D; Bradley, M.; Bau, R.; Olah, G. A.
"Preparation of and fluoroalkylation with (chlorodifluoromethyl)trimethylsilane,
difluorobis(trimethylsilyl)methane, and 1,1,2,2-tetrafluoro-1,2-bis(trimethylsilyl)ethane," J. Am. Chem. Soc. 1997, 119, 1572-1581.
5. Olah, G. A.; Rasul, G.; Yudin, A. K.; Prakash, G. K. S. "Ab initio/IGLO study of
sandwiched bishomoaromatic anti-Tricyclo[4.2.1.12,5]-deca-3,7-diene-9,10-diyl dication
and the trishomoaromatic trishomocyclopropenium Ion," Gazzetta Chimica Italiana 1996,
126, 1-5.
4. Olah, G. A.; Burrichter, A.; Rasul, G.; Yudin, A. K.; Prakash, G. K. S. "Preparation,
NMR, and ab initio/IGLO study of trifluoromethyl-substituted carboxonium ions," J. Org.
Chem. 1996, 61, 1934-1939.
3. Olah, G. A.; Rasul, G.; Yudin, A. K.; Burrichter, A.; Prakash, G. K. S.; Chistyakov, A.
K. Stankevich, I. V.; Akhrem, I. S.; Gambaryan, N. P. "Trihalomethyl cations and their
superelectrophilic activation," J. Am. Chem. Soc. 1996, 118, 1446-1451.
2. Prakash, G. K. S.; Yudin, A. K.; Deffieux, D; Olah, G. A. "Facile preparation of
(trifluoromethyl)tributyltin. Transtrifluoromethylation of disilyl sulfides to the
corresponding trifluoromethylsilanes," Synlett 1996, 151-153.
1. Prakash, G. K. S.; Deffieux, D; Yudin, A. K.; Olah, G. A. "Convenient and safe
electrochemical preparation of (trifluoromethyl)trimethylsilane," Synlett 1994, 12, 10571058.
b. Books
(a) Edited monograph: Aziridines and Epoxides in Organic Synthesis; Yudin, A. K., Ed.;
Wiley-VCH: Weinheim, Germany, 2006;
(b) Edited monograph: Transition Metal-Catalyzed Carbon-Heteroatom Bond Formation
Yudin, A. K., Ed.; Wiley-VCH: Weinheim, Germany, 2011;
c. Chapters in books
(a) Adusumalli, S. R.; Yudin, A. K.; Rai, V. “Cyclic peptides” in Natural Lactones and
Lactams, Wiley-VCH, 2013, edited by T. Janecki.
(b) “Phenyl-substituted aziridine aldehyde dimer” Adachi, S.; Yudin, A. K. e-EROS
(Encyclopedia of Reagents for Organic Synthesis), Release 6, RN00462, 2013.
13
(c) Caiazzo, A. and Yudin, A. K. “Synthesis of epoxides by ring-closure,” Science of
Synthesis 2008, vol. 37, 407-433.
(d) Chen, Y. and Yudin, A. K. “Polyfluorinated binaphthol ligands in asymmetric
catalysis” in Fluorine-Containing Synthons, ACS Symposium Series #911, Soloshonok,
V. A. Ed., Oxford University Press/American Chemical Society, Washington, D.C.,
2005; Chapter 16, pp 288-302.
(e) “N-Aminophthalimide” Krasnova, K. B.; Yudin, A. K. e-EROS (Encyclopedia of
Reagents for Organic Synthesis), Release 6, RN00462, 2004.
(f) Siu, T.; Picard, C. J.; Yudin, A. K. “Electrochemical nitrogen transfer reactions for
organic synthesis” In Mechanistic and Synthetic Aspects of Organic and Biological
Electrochemistry, D. G. Peters, J. Simonet, and H. Tanaka, Eds., The Electrochemical
Society, Inc., Pennington, New Jersey, 2003, pp. 105-108.
d. Selected highlights of the Yudin group research
-
by Stu Borman in Chemical & Engineering News article (2015, June 30th issue);
by Michael J. Haas in Nature Scibx (December 2014);
In Nature Macrocycles Collection (SciBx
2013));(http://www.nature.com/scibx/collections/macrocycles/index.html);
by Chris Cain in BioCentury (Sept. 17, 2012 issue);
by Stu Borman in Chemical and Engineering News 29 Aug. 2011 News of the
Week story dedicated to our discovery of amphoteric alpha-boryl aldehydes;
by Petra Dittrich in Lab Chip 2010, 10, 2835;
by Roger Freidinger in Biology Faculty of 1000
(http://f1000biology.com/article/id/4934957);
by John Morrow in Genetic Engineering and Biotechnology News (2010 , July 1
issue, vol. 30, No. 13);
by Jake Yeston in Science (2010, March 19th issue, p. 1430);
by Carmen Drahl in a Chemical & Engineering News article (2010, March 1st
issue, p. 34);
by Tom Kodadek in Biology Faculty of 1000
(http://www.f1000biology.com/article/id/2870956);
by Benjamin List (Synfacts 2010, 1, p. 110);
by Mark Lautens (Synfacts 2010, 3, p. 309);
by Paul Knochel (Synfacts 2010, 8, p.1123);
Interview with Nature
(http://blogs.nature.com/thescepticalchymist/2011/08/reactions
andrei_yudin.html);
Interview with The Varsity (http://thevarsity.ca/2012/01/30/a-molecularexchange-with-yudin/);
Article: Ontario Genomics Institute (http://www.ontariogenomics.ca/mediacentre/news/2011-9-28/703);
Webinar: Dr. Maureen Rouhi, a Senior Editor of Chemical & Engineering News
moderated a webinar dedicated to our technologies at the 241st ACS Meeting.
by G. Hilt in Angewandte Chemie International Edition (2002, 41 (19), p.3586);
by K. Philipkowski in WIRED News (Dec. 20, 2002);
by Steven K. Ritter in Chemical & Engineering News (2002, July 29th, p. 24);
14
-
by Pamela Zurer in Chemical & Engineering News (2002, January 28th, p. 14);
by Cathleen Crudden in Canadian Chemical News (2001, 53, 10, p. 11);
by Maureen Rouhi in Chemical & Engineering News (2000, September 4th, p.
40).
8. Marketed reagents
A wide range of synthetically versatile unprotected amino aldehydes (Sigma-Aldrich);
A wide range of boryl aldehydes (Sigma-Aldrich).
9. Invited lectures
244. ISACS-19 (Irvine, CA, April 2016);
243. Pacifichem (Symposium on Heterocycles, December 2015)
242. Pacifichem (Symposium on Peptides, December 2015);
241. GSK (King of Prussia, PA, October 2015);
240. University of Alberta (December 2015);
239. University of Montreal (December 2015);
238. RSC Symposium on Organic Synthesis (Shanghai, China, September 2015);
237. International Conference on Peptides (Pune, India, December 2015);
236. KOST-2015 International Conference on Heterocycles (Moscow, September 2015);
235. Vanderbilt University – Aldrich Symposium on New Trends in Organic Synthesis
(Nashville, TN, September 2015);
234. Xerox (Mississauga, September 2015);
233. Astex Pharmaceuticals (Cambridge, UK, August 2015);
232. ACS Northeastern Regional Meeting (Ithaca, NY, June 2015);
231. University of Toronto Ask a Laureate Lecture (May 2015);
230. University of Rochester (Chambers Lectures, Rochester, NY, September 2015);
229. American Society for Pharmacognosy (Copper Mountain, Colorado, July 2015);
228. Canadian Society of Chemistry Peptide and Protein Structure Symposium (Ottawa, June
2015);
227. Canadian Society of Chemistry Belleau Award Lecture (Ottawa, June 2015);
226. American Peptide Symposium (Orlando, Florida, June 2015);
225. 6th International Conference on Multicomponent Reactions (Brasilia, Brazil, April 2015);
221. Moscow Winter School on Heterocycles (Krasnovidovo, Russia, January 2015);
222. Boehringer-Ingelheim (Connecticut, 2015);
224. Merck Research Laboratories (Kenilworth, New Jersey, 2015);
223. GlaxoSmithKline (Boston, 2014);
220. Ottawa University (November, 2014);
220. Merck Research Laboratories (Kenilworth, New Jersey, 2014);
219. University of California, San Francisco (November, 2014);
218. University of California, Santa Cruz (November, 2014);
217. University of Mainz, Germany (September, 2014);
216. MCMC Conference (Molecular Complexity in Modern Chemistry), Moscow, Russia
(September, 2014);
215. Alphora Research, Oakville (July, 2014);
214. Biolomecular Self-assembly Symposium, Montpellier, France (October, 2014);
15
213. Sanofi-Aventis, Frankfurt, Germany (September, 2014);
212. 6th International Forum on Homogeneous Catalysis, Shanghai, China (October, 2014);
211. Purdue University (September, 2014);
210. French-American Chemical Society Meeting, Avignon, France (June, 2014);
209. Plenary lecture, ISOSDD-4, Xuzhou, China (May, 2014);
208. ACS Meeting, Macrocycles Symposium, Dallas, TX (March, 2014);
207. AstraZeneca (Boston, March 2014);
206. Boston University (March, 2014);
205. Oxford University (October, 2013);
204. University of Calgary (Calgary, February, 2014);
203. Heterocycles Conference, plenary speaker (Pyatigorsk, Russia, 2013);
202. Anacor Pharmaceuticals, San Francisco (August, 2013);
201. Simon Fraser University (October, 2013);
200. University of Victoria (October, 2013);
199. Fisher Scientific Sustainability Lecture, UBC (October, 2013);
198. Nanjing University, China (September, 2013);
197. Novartis, Boston (July, 2013);
196. American Chemical Society Meeting, Macrocycles Symposium, Dallas, TX (April, 2014);
195. Gordon Research Conference in High Throughput Chemistry and Chemical Biology (June,
2013);
194. Canadian Society for Chemistry Short Talk on Boron in Peptides, Quebec City (May,
2013);
193. Canadian Society for Chemistry Boron Chemistry Symposium, Quebec City (May, 2013);
192. Canadian Society for Chemistry Peptide Symposium, Quebec City (May, 2013);
191. American Peptide Symposium, Kona, Hawaii (June, 2013);
190. HRSMC Summer School, Maastricht, Netherlands (June, 2013);
189. Boston TIDES Symposium (May, 2013);
188. McMaster University (March, 2013);
187. RSC Editors Symposium (March, 2013);
186. University of Ottawa (January, 2013);
185. EUROTides conference, Berlin, Germany (November, 2012);
184. 7th Peptide Therapeutics Symposium, Salk Institute (September, 2012);
183. Amgen (September, 2012);
182. MIT-Skolkovo Symposium Moscow (July, 2012);
181. Hong Kong University (April, 2012);
180. Lanzhou University (April, 2012);
179. Shanghai Institute of Organic Chemistry Symposium (April, 2012);
178. Beijing University, OBC Symposium (April, 2012);
177. Cornell University (March, 2012);
176. Ithaca College (March, 2012);
175. Abbott Laboratories (March, 2012);
174. Mona Symposium on Natural Products (January, 2012);
173. University of Rochester (November, 2011);
172. University of Illinois, Urbana-Champaign (November, 2011);
171. TOKS Symposium, Copenhagen, Denmark (October, 2011);
170. Roche Colorado Peptide Symposium (September, 2011);
169. Symposium on New Frontiers of Organic Chemistry in Beijing (September, 2011);
168. American Peptide Symposium, San Diego (July, 2011);
16
167. Chemical and Engineering News Webinar – ACS, Anaheim (March, 2011);
166. MIT (January, 2011);
165. Brandeis University (January 2011);
164. Catalysis Symposium in Kunming, China (October, 2011);
163. University of Illinois at Chicago (November, 2010);
162. Pacifichem, Honolulu, Hawaii (December, 2010);
161. University of Pennsylvania (September, 2010);
160. Ensemble Therapeutics, Boston, MA (August, 2010);
159. Free University of Berlin (June, 2010);
158. University of Chicago (May, 2010);
157. Zing Conference on Natural Products in Sharm-el-Sheikh, Egypt (February 2010).
156. Plenary lecture at the Favorsky Conference in St. Petersburg, Russia (April 2010);
155. Gordon Research Conference on Chemistry and Biology of Peptides (March 2010);
154. Plenary lecture at the Nesmeyanov Conference in Moscow, Russia (September 2009);
153. Ontario Institute of Cancer Research (Toronto, July 2009);
152. Biopolis (Singapore, May 2009);
151. Nanyang Technological University (Singapore, May 2009);
150. Toronto BioDiscovery Showcase (April 2009);
149. Queens University (April 2009);
148. Brock University (April 2009);
147. Merck-Rahway (April 2009);
146. ETH-Zurich (March 2009);
145. University of Kaiserslautern (Kaiserslautern, March 2009);
144. University of Wurzburg (Wurzburg, March 2009);
143. Sanofi-Aventis (Frankfurt, March 2009);
142. Tokyo University of Science (Tokyo, December 2008);
141. New Mexico Institute of Technology (Socorro, New Mexico, November 2008);
140. ACS Prospectives in Organic Synthesis (Philadelphia, October 2008);
139. ISOSDD (Nanjing, China, October 2008);
138. GlaxoSmithKline (North Carolina, September 2008);
136. University of North Carolina-Chapel Hill (North Carolina, September 2008);
135. Merck-Rahway (New Jersey, August 2008);
134. Novartis Japan (Tsukuba, Japan, February 2008);
133. Hebrew University of Jerusalem (Jerusalem, Israel, March 2008);
132. Weizmann Institute (Rehovot, Israel, March 2008);
131. Technion-Israel Institute of Technology (Haifa, Israel, March 2008);
130. Tel Aviv University (Tel Aviv, Israel, March 2008);
129. University of Tokyo (Tokyo, Japan, February 2008);
128. Tokyo Agricultural University (Tokyo, Japan, February 2008);
127. Tokyo Institute of Technology (Tokyo, Japan, February 2008);
126. Zing Conference in Drug Discovery (Antigua, February 2008);
125. University of Belgrade (July 2007);
124. 5th Walden Symposium (Riga, Latvia, September 2007);
123. ORCP/BioDiscovery technology presentation (MARS, Toronto, June 2007);
122. Annual Ottawa Synthesis Day Symposium (Ottawa, June 2007);
121. G. A. Olah 80th birthday symposium (Los Angeles, October 2007);
120. Schering-Plough Research Institute (September, 2007);
119. ACS Symposium in Epoxidation Mechanisms (Boston, September 2007);
17
118. NOST Symposium (Goa, India, July 2007);
117. Centre National de la Recherche Scientifique, Gif-sur-Yvette (France, May 2007);
116. University of Lyon (May 2007);
115. California Institute of Technology (April 2007);
114. Stanford University (April 2007);
113. The Scripps Research Institute (April 2007);
112. University of California, Berkeley (April 2007);
111. University of Wisconsin (March 2007);
110. University of California at Santa Barbara (August 2006);
109. Gordon Research Conference in Stereochemistry (Newport, Rhode Island, June 2006);
108. ORDCF Workshop at McMaster University (June 2006);
107. Earl Haig High School (Toronto, Ontario, May 2006);
106. Canadian Society for Chemistry- Organic Synthesis Symposium (Halifax, May 2006);
105. The Electrochemical Society Meeting (Denver, May 2006);
104. Pfizer Symposium (Toronto, Ontario, May 2006);
103. Olah Award Symposium (Atlanta, Georgia, March 2006);
102. University of Waterloo (March, 2006);
101. University of Toronto – Mississauga (March 2006);
100. Pacifichem Meeting – Catalytic C-N Bond Forming Reactions Symposium (Honolulu,
Hawaii, December 2005);
99. Max-Planck Institute (Mulheim, Germany, September 2005);
98. ASDD-5 (Advances in Synthesis for Drug Discovery) Conference (Moscow, Russia, July
2005);
97. AC3 – Prospective Trends in Organic and Biological Electrochemistry (Quebec City, May
2005);
96. University of Sherbrooke (April 2005);
95. Invited lecture at the ISOETC symposium (Osaka, March 2005);
94. Invited lecture at the Japanese Fluorine Society Meeting (Tokyo, November 2004);
93. Joint ACS Meeting, Organic Electrochemistry Symposium (Honolulu, Hawaii, October
2004);
92. University of Utah (Salt Lake City, September 2004);
91. Colorado State University (Fort Collins, Colorado, September 2004);
90. Cottrell Scholars Conference (Tucson, Arizona, June 2004);
89. University of Bristol (United Kingdom, May 2004);
88. University of Leeds (United Kingdom, May 2004);
87. Oxford University (United Kingdom, May 2004);
86. University of Liverpool (United Kingdom, May 2004);
85. University of York (United Kingdom, May 2004);
84. University of Manchester (United Kingdom, May 2004);
83. University of Zurich (Switzerland, April 2004);
82. ETH Zurich (Switzerland, April 2004);
81. ACS Symposium in Fluorine Chemistry (California, March 2004);
80. Amgen (California, March 2004);
79. Purdue University (Indiana, November 2003);
78. Indiana University (Indiana, November 2003);
77. 226th ACS National Meeting, Symposium “Synthetic Organic Electrochemistry” (New York,
September 2003);
18
76. 226th ACS National Meeting, Symposium “Fluorinated Synthons” (New York, September
2003);
75. ORDCF Workshop in Thin Films (Toronto, Ontario, August 2003);
74. Kyoto University (July 2003);
73. Tokyo Institute of Technology (July 2003);
72. Asahikasei (July 2003);
71. Sumitomo Chemical (July 2003);
70. German Society of Chemistry (DFG Darmstadt, June 2003);
69. BASF (June 2003);
68. Merck AG (June 2003);
67. Plenary lecture, Division of Synthetic Chemistry, Kinki Chemical Society in Japan (Japan,
August 2003);
66. ISHHC-11, International Symposium on Relations between Homogeneous and
Heterogeneous Catalysis (Chicago, Illinois, July 2003);
65. OMCOS-12, Organometallic Chemistry for Organic Synthesis (Toronto, Ontario, July 2003);
64. AC3, Mechanistic and Synthetic Apects of Organic and Biological Electrochemistry (Paris,
France April 27- May 2, 2003);
63. University of Guelph (April 2003);
62. McGill University (March 2003);
61. University of Western Ontario (March 2003);
60. Moscow State University (Moscow, Russia, February 2003);
59. Plenary lecture: Sixteenth Winter Fluorine Conference “Discovering New Roles for Fluorine:
From Enzymes to Microlithography” (St. Pete Beach, Florida, January 12-17, 2003);
58. Affinum Pharmaceuticals (Toronto, November 2002);
57. University of Southern California (Los Angeles, November 2002);
56. University of Victoria (October 2002);
55. University of British Columbia (October 2002);
54. Simon Fraser University (October 2002);
53. The Scripps Research Institute (California, October 2002);
52. Eli Lilly (Indiana, August 2002);
51. ICOS-14 IUPAC Congress on Organic Synthesis (Christchurch, New Zealand, July 2002);
50. Gordon Research Conference in Green Chemistry (Oxford University, UK, July 2002);
49. Gordon Research Conference in Heterocycles (Salve Regina University, July 2002);
48. Gordon Research Conference in Organic Reactions and Processes (Bristol, July 2002);
47. McMaster University (April 2002);
46. Northwestern University (April 2002);
45. University of Chicago (April 2002);
44. Cottrell Awardees Conference (Arizona, July 2002);
43. University of Cologne (Germany, April 2002);
42. University of Bochum (Germany, April 2002);
41. 2002 Organic and Bioorganic Workshop for Leading, Young Canadian Chemists (Victoria,
May 2002);
40. NSF Workshop in Physical Organic Chemistry (South Carolina, June 2002);
39. Gordon Research Conference in Stereochemistry (Newport, Rhode Island, June 2002);
38. University of Calgary (November 2001);
37. University of Windsor (November 2001);
36. University of Ottawa (September 2001);
19
35. Cohausz & Florack - keynote speaker “IP Strategy in Chemical Research” (Dusseldorf,
Germany, September 2001);
34. DuPont (Delaware, September 2001);
33. Gordon Research Conference in Organic Reactions and Processes (Bristol, July 2001);
32. University of Okayama (Okayama, Japan, July 2001);
31. North American Catalysis Symposium (Toronto, June 2001);
30. Eastman Kodak (Rochester, June 2001);
29. Bayer AG (Germany, June 2001);
28. University of Muenster (Germany, June 2001);
27. University of Aachen (Germany, June 2001);
26. University of Illinois-Chicago (Illinois, April 2001);
25. Applied Biosystems (California, April 2001);
24. ACS Symposium on Selectivity in Organic Chemistry and Catalysis (San Diego, CA, April
2001);
23. Boehringer-Ingelheim (Montreal, January 2001);
22. Symyx Technologies (Santa Clara, CA, December 2000);
21. Pacifichem 2000 Symposium: “Discovery and Development of Asymmetric Synthesis and
Chiral Technology Symposium” (Hawaii, December 2000);
20. Pacifichem 2000 Symposium: “New Synthetic Methods in Organofluorine Chemistry”
(Hawaii, December 2000);
19. University of Montreal (October 2000);
18. University of Alberta (October 2000);
17. BioChem Pharma (October 2000);
16. Merck Frosst (September 2000);
15. AstraZeneca (September 2000);
14. MethylGene (September 2000);
13. ACS Symposium on Asymmetric Catalysis (Washington, DC, August 2000);
12. Sumitomo Chemical (Takatsuki, Japan, July 2000);
11. University of Tokyo (Tokyo, Japan, July 2000);
10. Gordon Research Conference in Organometallic Chemistry (Salve Regina University, USA,
July 2000);
9. Gordon Research Conference in Combinatorial Chemistry (Il Ciocco, Italy, May 2000);
8. University of Southern California (Los Angeles, USA, May 2000);
7. California Institute of Technology (Pasadena, California, May 2000);
6. Dow Chemical (Midland, MI, February 2000);
5. Xerox (January 2000);
4. University of Guelph (January 2000);
3. Medtronic Inc. (Minnesota, USA, October 1999);
2. University of Southern California (Los Angeles, USA, April 1999);
1. Bioanalytical Systems Inc. (Indiana, USA, December 1998).
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