Assessing the impact of the built environment on human mortality during extreme heat events with LANDSAT data David M. Hondula, Robert E. Davis (advisor), University of Virginia Extreme heat events pose a significant public health burden and are the leading weather-related cause of mortality in the United States. Episodes of extreme heat are particularly problematic in urban areas, where built environment features contribute to elevated air and surface temperatures and expose residents to greater thermal stress. We sought to determine the extent to which environmental factors contribute to spatial variability in heat-related risk. The dependent variable for the study was postal-code level mortality rates on extreme heat days, derived from multidecadal mortality records from seven climatically diverse U.S. cities. Independent variables included built environment characteristics from the National Land Cover Database and a suite of demographic indicators. We used multivariate regression to identify variables most associated with regions of elevated risk. In all cities we found significant spatial variability in heat-related mortality. High risk zones were generally associated with a greater extent of high intensity development/reduced natural landscapes, lower income levels, and lower educational attainment. As metrics related to the extent of development were included in a number of the city-specific regression models, we cannot reject the hypothesis that built environment features contribute to adverse health outcomes through urban heat island effects.