The Method of Fundamental Solutions in Solving Coupled Boundary Value Problems for EEG/MEG Salvatore Ganci University of Palermo Viale delle Scienze, Edificio 9, Palermo, Italy email@example.com Keywords. Neuroimaging; Method of Fundamental Solutions; EEG/MEG forward problem. Estimation of neuronal activity in the human brain from electroencephalography (EEG) and/or magnetoencephalography (MEG) signals is a typical inverse problem whose solution process requires an accurate and efficient forward solver [1-2]. We introduce the Method of Fundamental Solution (MFS) [3-4] as a truly meshless, boundary-type, integration-free and easy to implement alternative to the state of the art Boundary Element Method (BEM) for solving the EEG/MEG forward problem. The solution of the forward problem is obtained via the Method of Particular Solutions (MPS) by numerically solving a set of coupled boundary value problems for the 3D Laplace equation which has well behaved analytic fundamental solutions. Accuracy, convergence and computational load are investigated and comparisons with BEM show the potentiality of the proposed method. Acknowledgements Joint work with Guido Ala, Gregory Fasshauer, Elisa Francomano and Mike McCourt. References  Hallez H. et al. (2007) “Review on solving the forward problem in EEG source analysis.” Journal of Neuroengineering and Rehabilitation, Vol. 4, p. 46.  Hämäläinen M. et al. (1993) “Magnetoencephalography–theory, instrumentation, and applications to noninvasive studies of the working human brain." Reviews of Modern Physics, Vol. 65, p. 413.  Fairweather G., Karageorghis A. (1998) “The method of fundamental solutions for elliptic boundary value problems.” Advances in Computational Mathematics, Vol. 9.1-2, pp. 69-95.  Golberg M.A., Chen C.S. (1998) “The method of fundamental solutions for potential, Helmholtz and diffusion problems.” Boundary Integral Methods Numerical and Mathematical Aspects, pp. 103-176.