Jordan University of Science and Technology
Faculty of Medicine
Department of Pharmacology
1. Name and Academic Rank: Professor Mazen M. Hasan, M. D., Ph.D.
2.
Degrees with fields, institution and date:
M.B. B.S.
degree (1973-1980), Faculty of Medicine, University of Jordan, Amman-Jordan (1980).
Internship (1980-1981), Ministry of Health Hospitals, Jordan.
Ph. D. in Pharmacology (1982-1986), School of Medicine, State University of New York (SUNY) at Buffalo,
New York, U.S.A (1986).
3.
Years of Service on JUST at Department of Pharmacology in the Faculty of Medicine:
1986-1994 and 1997-2009
Date of Original Appointment: 1986
4. Other related experiences-teaching, industrial, etc:
Lecturer: Department of Pharmacology, Faculty of Medicine, University of Jordan (1981-1982).
Teaching Staff (Associate Professor): Amman National University, Jordan (1994-1997).
5. Consulting, patents, etc.: Supervisor on clinical studies dealing with bioavailability/bioequivalence
research conducted at JUST.
6. Principal publication of the last three years:
Otoom S, Nusier M, Hasan M, Hadidi H, Samawi R, Younes AM, Darweesh M, and Boulatova NR. The
association of polycystic ovaries with use of valproate in Jordanian epileptic patients. Clin. Drug Invest. 23
(8): 527-532 (2003).
Otoom, S., Hasan, M., and Najib, N. Comparative bioavailability of two cefadroxil products using serum
and urine data in healthy human volunteers. Clinical andExperimental Pharmacology and Physiology 31:
433-437 (2004).
Hasan, M, Otoom, S., Najib, N., and Sallam, E.-S. A two-way cross-over bioequivalence study
comparing two products of diclofenac sodium suppositories in healthy human volunteers. Basic and
Clinical Pharmacology and Toxicology (2004).
7.
Scientific and professional societies:
_
A member of Jordan Medical Association (1981-).
_
An "Honorary Consultant" for Middle East Medical Index (1989-).
_
A reviewer for two journals (Clinical Drug Investigation and The Annals of Pharmacotherapy)
published by Harvey Whitney Books Company (1992-).
_
A member of New York Academy of Sciences (1994-).
_
A member of the National Geographic Society (1996-).
_
Listed in Who's Who in the World (14th Edition, 1997).
_ Jordanian Board in Basic Medical Sciences (Pharmacology), Jordan Medical Council, Amman-Jordan,
November 1997.
8.
Honors and awards:
9. Institutional and professional services in the last five years:
10. Professional development activities in the last five years:
‫جامعة العلوم والتكنولوجيا األردنية‬
‫كلية الطب‬
‫قسم علم األدوية‬
‫‪ .1‬االسم والرتبة االكاديمية‪ :‬مازن محمود حسن (أستاذ)‬
‫‪ .2‬الدرجات العلمية والتخصصات والجامعات وتواريخها‪:‬‬
‫‪ .3‬عدد سنوات الخبرة في قسم (علم األدوية)‪ /‬جامعة العلوم والتكنولوجيا ‪ 23‬عاما‬
‫تاريخ التعيين‪1986 :‬‬
‫‪ .4‬خبرات أخرى ذات عالقة ( تدريسية‪ ,‬صناعية‪...,‬الخ)‪.‬‬
‫ محاضر متفرغ في كلية الطب‪ /‬الجامعة األردنية (‪)1982 – 1981‬‬‫ أستاذ مشارك في كلية الصيدلة‪ /‬جامعة عمان األهلية (‪)1997 – 1994‬‬‫‪ .5‬استشارات‪ ,‬براءات اختراعات‪....,‬الخ‪.‬‬
‫‪ .6‬األبحاث المهمة المنشورة خالل الخمس سنوات األخيرة‪:‬‬
‫‪ .7‬العضوية في هيئات علمية ومهنية ‪:‬‬
‫‪ .8‬الجوائز والمنح‪:‬‬
‫‪ .9‬الخدمات االكاديمية والمهنية في الخمس سنوات األخيرة ‪:‬‬
‫‪ .10‬نشاطات تطوير المهنة في الخمس سنوات األخيرة‪:‬‬
‫جدول ‪ :1-4‬معلومات عضو هيئة التدريس في قسم علم األدوية‬
‫الرتبة‬
‫صنف التعيين‬
‫(مثبت أو غير مثبت)‬
‫متفرغ أو غير متفرغ‬
‫أعلى درجة علمية والتخصص‬
‫اسممم و بلممد الجامعممة التممي حصمم‬
‫منهممما علمممى أعلمممى درجمممة علميمممة‬
‫وسنة الحصول عليها‬
‫الخبرة في المؤسسات‬
‫الحكومية والصناعية‬
‫والتدريب‬
‫الخبرة في جامعات‬
‫أخرى‬
‫الخبرة في هذه الجامعة‬
‫العضوية في هيئات مهنية‬
‫هيئات مهنية‬
‫البحث العلمي‬
‫مازن محمود حسن‬
‫أستاذ‬
‫مثبت‬
‫متفرغ‬
‫أستاذ‬
‫في علم‬
‫األدوية‬
‫‪ 3‬سنوات‪/‬‬
‫جامعة عمان‬
‫األهلية‬
‫سنة في‬
‫الجامعة‬
‫األردنية‬
‫‪ 23‬عام‬
‫االستشارات والعم‬
‫الصيفي في قطاع‬
‫الصناعة‬
‫االسم‬
‫سنوات الخبرة‬
‫مستوى النشاط (عا ٍل‪ ,‬متوسط‪,‬‬
‫ضعيف‪ ,‬بدون) في‪:‬‬
‫عال‬
‫ مالحظات‪ :‬تعبأ بيانات جميع أعضاء هيئة التدريس في البرنامج ويمكن استعمال صفحات إضافية عند الحاجة ويجب أن تعكس المعلومات الخاصة بمستوى‬‫النشاط إذا كانت مدته ألكثر من عام‪.‬‬
‫‪4‬‬
‫جدول ‪ : 2-4‬ملخص العبء التدريسي لعضو هيئة التدريس في قسم علم األدوية‬
‫‪ -1‬اذكر الفص والسنة التي تنطبق عليها البيانات‪.‬‬
‫اسم عضو هيئة‬
‫التدريس‬
‫مازن محمود حسن‬
‫‪5‬‬
‫متفرغ‬
‫أو غير‬
‫متفرغ‬
‫الشعب التي تم تدريسها (رقم المساق ‪-‬‬
‫الساعات المعتمدة ‪ -‬الفص الدراسي والسنة‬
‫الدراسية) ‪1‬‬
‫متفرغ‬
‫ط ‪ 251‬علم األدوية العام العام (الفص األول من‬
‫ك عام)‪ 3 /‬ساعات معتمدة‬
‫ط ‪ 322‬الجهاز العصبي ‪( 1‬الفص الثاني من ك‬
‫عام)‪ /‬عدد الساعات (مشترك)‬
‫ط ‪ 352‬الجهاز البولي والتناسلي (الفص األول‬
‫من ك عام)‪ /‬عدد الساعات (مشترك)‬
‫ط ‪ 751‬علم األدوية السريرية والدوائية لطلبة‬
‫التمريض (الفص األول من ك عام)‪ 3 /‬ساعات‬
‫معتمدة‬
‫ط ‪ 752‬علم األدوية المتقدم (الفص األول من ك‬
‫عام)‪ 3 /‬ساعات معتمدة‬
‫النسبة المئوية لك نشاط‬
‫‪2‬‬
‫التدريس‬
‫البحث العلمي‪/‬‬
‫والنشاطات العلمية‬
‫نشاطات أخرى بما‬
‫في ذلك إجازات‬
‫‪3‬‬
‫التفرغ العلمي‬
‫‪%90‬‬
‫‪%10‬‬
‫‪ -2‬يوزع النشاط بالنسبة المئوية بحيث يكون المجموع ‪.%100‬‬
‫‪ -3‬اذكر اجازات التفرغ العلمي ‪....‬الخ تحت عمود النشاطات األخرى‪.‬‬
‫‪6‬‬
‫جدول ‪ :3-4‬االجتماعات والمؤتمرات التي شارك بها أعضاء الهيئة التدريسية في قسم ‪.....‬‬
‫االسم‬
‫المؤتمر‪ /‬االجتماع‬
‫مكان اإلنعقاد‬
‫السنة‬
‫جدول ‪ :4-4‬ورش العم التي أخذها أعضاء الهيئة التدريسية في قسم ‪................‬‬
‫االسم‬
‫ورشة العم‬
‫مكان اإلنعقاد‬
‫السنة‬
‫جدول ‪ :5-4‬المشاريع المدعومة التي حص عليها أعضاء الهيئة التدريسية في قسم ‪......‬‬
‫عنوان المشروع‬
‫فريق العم‬
‫جهة الدعم‬
‫موازنة المشروع بالدينار‬
‫األردني ومدة تنفيذه‬
‫جدول ‪ :6-4‬خدمة المجتمع التي شارك بها أعضاء الهيئة التدريسية في قسم ‪.............‬‬
‫اسم المشروع‪/‬الخدمة‬
‫فريق العم‬
‫الشركة أو‬
‫الهيئة‬
‫طبيعة‬
‫المشروع‪/‬الخدمة‬
‫تاريخ تنفيذ‬
‫المشروع‪/‬الخدمة‬
‫جدول ‪ :7-4‬ورش العم التي نفذها أعضاء الهيئة التدريسية في قسم ‪................‬‬
‫االسم‬
‫ورشة العم‬
‫مكان اإلنعقاد‬
‫السنة‬
‫جدول ‪ :8-4‬اإلرشاد االكاديمي في قسم علم األدوية‬
‫سنة قبول‬
‫الطلبة‬
‫األرقام الجامعية للطلبة‬
‫‪2008‬‬
‫‪40-1‬‬
‫‪80-41‬‬
‫‪120-81‬‬
‫‪160-121‬‬
‫‪40-1‬‬
‫‪80-41‬‬
‫‪120-81‬‬
‫‪160-121‬‬
‫‪40-1‬‬
‫‪80-41‬‬
‫‪120-81‬‬
‫‪160-121‬‬
‫‪40-1‬‬
‫‪80-41‬‬
‫‪120-81‬‬
‫‪160-121‬‬
‫‪40-1‬‬
‫‪80-41‬‬
‫‪120-81‬‬
‫‪160-121‬‬
‫‪2007‬‬
‫‪2006‬‬
‫‪2005‬‬
‫‪2004‬‬
‫المرشد االكاديمي‬
‫√‬
‫√‬
‫√‬
‫√‬
‫√‬
‫جدول ‪ :9-4‬مشاركة أعضاء هيئة التدريس في قسم علم األدوية في لجان القسم‬
‫أعضاء هيئة التدريس‬
‫اللجنة‬
‫√‬
‫الخطة الدراسية‪/‬االعتماد‬
‫√‬
‫ترقية أعضاء هيئة التدريس‬
‫√‬
‫البحث العلمي‬
‫√‬
‫الدراسات العليا‬
‫√‬
‫اختيار أعضاء هيئة التدريس‬
‫√‬
‫الكتب المقررة‬
‫المختبرات والسالمة‬
‫التدريب العملي‬
‫تنسيق الرحالت العلمية‬
‫يوم الخريج‬
‫تطبيقات الحاسوب واالنترنت‬
‫النوادي و الجمعيات الطالبية‬
‫√‬
‫جدول ‪ :10-4‬مشاركة أعضاء هيئة التدريس في قسم علم األدوية في لجان كلية الطب‬
‫أعضاء هيئة التدريس‬
‫اللجنة‬
‫االعتماد‬
‫ترقية أعضاء هيئة التدريس‬
‫البحث العلمي‬
‫الدراسات العليا‬
‫السالمة‬
‫√‬
‫√‬
‫√‬
‫جدول ‪ :11-4‬مشاركة أعضاء هيئة التدريس في قسم علم األدوية في لجان الجامعة‬
‫أعضاء هيئة التدريس‬
‫اللجنة‬
‫الجودة واالعتماد‬
‫البحث العلمي‬
‫الدراسات العليا‬
‫السالمة‬
‫√‬
‫√‬
‫‪1‬‬
‫جدول ‪ :12-4‬بيانات الترقية ألعضاء هيئة التدريس في قسم علم األدوية‬
‫االسم‬
‫تاريخ التعيين‬
‫الرتبة عند‬
‫التعيين‬
‫الترقية األولى‬
‫وتاريخها‬
‫الترقية الثانية‬
‫وتاريخها‬
‫مازن محمود حسن‬
‫‪1986‬‬
‫أستاذ مساعد‬
‫أستاذ مشارك‬
‫‪1991‬‬
‫أستاذ ‪1999‬‬
‫‪2‬‬
‫الترقية الثالثة‬
‫وتاريخها‬
CURRICULUM VITAE
PROFESSOR MAZEN M. HASAN
Nov. 9, 2009
3
TABLE OF CONTENTS
PAGE NO
NAME
1
ADDRESS
1
PERSONAL DATA
1
ACADEMIC QUALIFICATIONS
1
REFERENCES
2
ACADEMIC CAREER AND TEACHING EXPERIENCE
2
MEMBERSHIP OF ACADEMIC COUNCILS
5
MEMBERSHIP OF FACULTY COMMITTEES
5
SCIENTIFIC RESEARCH
6
SERVICES TO THE COMMUNITY
10
SERVICES TO THE UNIVERSITY AND FACULTY OF MEDICINE
10
MEMBERSHIP OF PROFESSIONAL SOCIETIES
11
ABSTRACTS
11
REPORTS
13
PUBLICATIONS
16
4
CURRICULUM VITAE
Name: Mazen M. Hasan, M.D., Ph.D.
Address:
Department of Pharmacology
Faculty of Medicine
Jordan University of Science and Technology
P.O. Box 3030
Irbid 22110
Jordan
Phone no.: 962-2-7201000, Ext. 23866 (Office) & 962-2-7277750 (Home)
Fax no.: 962-2-7095010, (Institute) & 962-2-7277750 (Home)
E-mail: mazen@just.edu.jo
Telex: 55545 JUST JO
Personal Data:
Date of birth: July 19, 1954
Place of birth: Jerusalem
Nationality: Jordanian
Marital Status: Married
Children: One daughter; May (May 14, 1991) and three sons; Hamza (Oct. 2, 1992), Ali
(Nov. 21, 1995), and Mohammed Noor (Dec. 28, 1999)
Academic Qualifications:
1. M.B., B.S. (1973-1980)
Faculty of Medicine, University of Jordan, Amman-Jordan
2. Internship (1980-1981)
Ministry of Health Hospitals, Jordan.
3. Ph.D. (1982-1986)
A four-year scholarship from Yarmouk University for Ph.D. studies in pharmacology.
Field of Study: Pharmacology and toxicology.
Title of Thesis: An Investigation on Metaldehyde Toxicity in Mice.
Institution: School of Medicine, State University of New York (SUNY) at Buffalo, New York,
U.S.A.
Thesis Advisor: Professor Peter K. Gessner
5
REFERENCES:
1.
Professor Hakam F. Hadidi
Department of Pharmacology
University of Science and Technology
Irbid 22110, Jordan
P. O. Box 3030
2.
Professor Peter K. Gessner, Associate Chairman
Department of Pharmacology and Therapeutics
School of Medicine
State University of New York (SUNY) at Buffalo
Buffalo, New York 14214, U.S.A.
3.
Professor Naji M. Najib
Faculty of Pharmacy
University of Science and Technology
Irbid 22110, Jordan
P. O. Box 3030
4.
Professor Yousry M. El-Sayed
Department of Pharmaceutics
College of Pharmacy
King Saud University, Riyadh
Riyadh 11451, Saudi Arabia
P. O. Box 2457
ACADEMIC CAREER AND TEACHING EXPERIENCE:
I. Instructor of pharmacology (1981/1982), Faculty of Medicine, University of Jordan,
Amman-Jordan.
II. Teaching Assistant (1982-1986), State University of New York at Buffalo, U.S.A.
III. Assistant Professor of pharmacology (1986-1991), Department of Pharmacology,
Faculty of Medicine, University of Science and Technology, Irbid-Jordan.
IV. Acting Chairman for Department of Pharmacology (1988-1991 and 1999-2001),
Faculty of Medicine, University of Science and Technology, Irbid-Jordan.
V. Associate Professor of pharmacology (1991-1994), Department of Pharmacology,
Faculty of Medicine, University of Science and Technology, Irbid-Jordan.
VI. Associate Professor of pharmacology and toxicology (1994-1997), Faculty of Pharmacy
and Medical Sciences, Amman University, Amman-Jordan.
VII. Associate Professor of pharmacology (1997-1999), Department of Pharmacology,
Faculty of Medicine, University of Science and Technology, Irbid-Jordan.
VIII. Professor of pharmacology (1999), Department of Pharmacology, Faculty of Medicine,
University of Science and Technology, Irbid-Jordan.
IX. Chairman for Department of Pharmacology (1999-2009), Faculty of Medicine,
University of Science and Technology, Irbid-Jordan.
6
X. Teaching the following courses in Faculties of Medicine, Pharmacy, Dentistry,
Nursing, and Allied Medical Sciences:
1. Pharmacology for medical students (Med 355), University of Science and Technology
(1986-1994 and 1997-2000).
2. Pharmacology for pharmacy students (Med 450), University of Science and Technology
(1987-1994 and 1997-).
3. Pharmacology for pharmacy students (Med 451), University of Science and Technology
(1987-1994 and 1997-2000).
4. Pharmacology for dentistry students (Med 351), University of Science and
Technology (1986-1994 and 1997-).
5. Pharmacology for nursing students (Med 255), University of Science and Technology
(1986-1994 and 1997-).
6. Toxicology for nursing students (Med 256), University of Science and Technology
(1988-1994).
7. Clinical pharmacy for pharmacy students (Pharm 441), University of Science and
Technology (1986-1990).
8. Clinical pharmacy for pharmacy students (Pharm 442), University of Science and
Technology (1986-1990).
9. Dental therapeutics and practice for dentistry students (Dent 321), University of Science
and Technology (1988- 1994).
10. Pharmacology for nursing and midwifery students, Nusayba Al-Maziniah
College of Nursing and Midwifery, Ministry of Health (1992/1993 and 1998-2001).
11. Pharmacology I for pharmacy students (92331), Amman University (1994-1997).
12. Pharmacology II for pharmacy students (92332), Amman University (1994-1997).
13. Toxicology for pharmacy students (91431), Amman University (1994-1996).
14. Toxicology for pharmacy students (Pharm 544), University of Science and Technology
(1994/1995).
15. Pharmacology and toxicology practical for pharmacy students, Amman University
(1994-1996).
16. Biopharmaceutics and pharmacokinetics for pharmacy students (91467), Amman
University (1995-1997).
17. General pharmacology for medical students (Med 251), University of Science and
Technology (2000).
18. Clinical Pharmacology and therapeutics for graduate nursing students (Med 751),
University of Science and Technology (2000).
19. Ophthalmic Pharmacology for optometry students (Op 366), University of Science and
Technology (2002).
7
20. The pharmacology lectures of the Hematopoietic and Lymphoid System (Med 272),
University of Science and Technology (2001).
21. The pharmacology lectures of the Endocrine System (Med 310), University of Science
and Technology (2001).
22. The pharmacology lectures of the Genito-urinary System (Med 352), University of
Science and Technology (2001).
23. The pharmacology lectures of the CNS I (Med 322), University of Science and
Technology (2005).
24. Several advanced courses for the master degree program in pharmacology.
X. Participation in professional meetings for education:
1. First National Conference on Medical Education, University of Jordan, Amman-Jordan,
6 November 1986.
2. A Workshop on Medical Education, University of Science and Technology, IrbidJordan, 29 August-3 September, 1987.
3. The Regional Conference for Medical Education of Eastern Mediterranean Region,
Amman-Jordan, 14-17 February 1988.
4. A Workshop in Instructional Technology and Evaluation, University of Science and
Technology, Irbid-Jordan, 31 August-4 September 1991.
5. Sub-regional Workshop on the Introduction of Essential Drugs and
Rational Prescribing Concepts into University Curricula, Beirut-Lebanon,
18-20 October 1992.
6. A Workshop on Trans-dermal Drug Delivery, Arab Company for Drug Industries and
Medical Appliances (ACDIMA), Amman-Jordan, 6 May 1993.
7. A Computer Course in Disk Operating System (DOS), Windows, and Excel, Amman
University, Amman-Jordan (1995).
8. Medical Education in the third Millenium, WHO, Jordan University of Science and
Technology, and AMEEMR, Irbid-Jordan, 11-13 June 2000.
9. A Workshop on Approaches to Learning and Teaching in Integrated Curriculum, IrbidJordan, JUST, 28th February and 1st March, 2001.
10. A Workshop on Evidence Based Medicine, Jordan University of Science and
Technology, Irbid-Jordan,12th April, 2001.
11. Several workshops on Integrated Medical Curriculum conducted by collaboration
between Scottish Medical Schools (Edinburgh, Glasgow, Newcastle, and Aberdeen) and
Jordan University of Science and Technology, June 2001, UK.
12. A Workshop on Pharmacovigilance, Drug Safety Research Unit, Jordan University of
science and Technology, Irbid-Jordan, 27th March, 2002.
8
XI. Medical examinations passed successfully:
1. ECFMG (16 September 1981)
2. VQE (27 October 1983).
XII. Academic guidance of medical students (University of Science and Technology) and
pharmacy students (Amman University).
MEMBERSHIP OF ACADEMIC COUNCILS:
1. The Council of Department of Basic Medical Sciences (1986-1987), Faculty of Medicine,
University of Science and Technology.
2. The Council of Department of Physiology and Pharmacology (1987-1988), Faculty of
Medicine, University of Science and Technology.
3. The Council of Department of Pharmacology (1988-1994 and 1997-), Faculty of Medicine,
University of Science and Technology.
4. The Council of Faculty of Medicine (1986/1987, 1988-1991, 1992/1993, and 1998-),
University of Science and Technology.
5. The Council of Department of Pharmacy (1994-1997), Faculty of Pharmacy and Medical
Sciences, Amman University.
6. The Council of Faculty of Pharmacy and Medical Sciences (1995- 1997), Amman
University.
MEMBERSHIP OF FACULTY COMMITTEES:
1.
Scientific Research Committee (1986/1987), Faculty of Medicine, University of Science and
Technology.
2.
Curriculum Committee (1989-1991 and 1997-), Faculty of Medicine, University of Science
and Technology.
3.
Committee of Scientific Conferences and Seminars (1986-1994, 1998/1999, and
1999/2000), Faculty of Medicine, University of Science and Technology.
4.
Committee for the Celebration of Medical Student Graduation (1989/1990), Faculty of
Medicine, University of Science and Technology.
5.
Committee for Medical Education (1990/1991), Faculty of Medicine, University of Science
and Technology.
6.
Committee for the Academic Guidance of Medical Students (1991/1992, 1999/2000, and
2000/2001), Faculty of Medicine, University of Science and Technology.
7.
Chairman of the Scientific Research Committee (1993/1994), Faculty of Medicine,
University of Science and Technology.
Student Punishment Committee (1995/1996), Faculty of Pharmacy and Medical Sciences,
Amman University.
8.
9.
Clinical Pharmacy Committee (1995/1996), Faculty of Pharmacy, Amman University.
9
10. A proposed "Center for Bioavailability Studies" (1995/1996), Faculty of Pharmacy and
Medical Sciences, Amman University.
11. Student Affairs Committee of Pharmacy Students (Amman University, 1996/1997) and
Medical Students(University of Science and Technology, 2000/2001).
12. The Committee of the Curriculum of Medical Education, Faculty of Medicine, University of
Science and Technology (2000).
SCIENTIFIC RESEARCH:
I.
AREAS OF INTEREST:
1. Clinical pharmacology and pharmacokinetics.
2. Therapeutic drug monitoring.
3. Comparative bioavailability-bioequivalence studies.
4. Gastrointestinal clearance of drugs by activated charcoal.
5. Antidotal treatment of metaldehyde intoxication.
6. Anesthetic and anticonvulsant effects of propofol.
7. Pharmacokinetic and bioequivalence studies on conventional, sustained-release, and
suppository formulations of non- steroidal anti-inflammatory drugs, such as diclofenac
sodium, indomethacin, ibuprofen, mefenamic acid, and piroxicam.
8. Pharmacokinetic and bioequivalence studies on selected penicillins (amoxicillin and
clavulanic acid), cephalosporins (cefadroxil, cefaclor, and cefuroxime), macrolides
(clarithromycin and azithromycin), and quinolones (ciprofloxacin).
9. Pharmacokinetic and bioequivalence studies on selected H2-receptor blockers (ranitidine and
famotidine), proton pump inhibitors (omeprazole and lansoprazole), and selected H1receptor blockers (loratadine and chlorpheniramine maleate).
10. Pharmacokinetic-pharmacodynamic and bioequivalence studies on glibenclamide
(glyburide) as an oral hypoglycemic drug.
11. Pharmacokinetic and bioequivalence studies on selected antihypertensive drugs
(nifedipine and atenolol).
12. Effects of the extract of certain medicinal plants on the heart in vitro.
13. Pharmacology and toxicology studies on new anticonvulsant drugs.
II. CO-INVESTIGATOR IN RESEARCH PROPOSALS:
1. Design and monitoring of drug plasma levels for optimal therapeutic response (42/87).
Submitted by Dr. Yousry M. EL-Sayed as a principal investigator. Supported by the
Deanship of Scientific Research and Graduate Studies, Jordan University of Science and
Technology (1987).
10
2. Effect of oral activated charcoal on the systemic clearance of drugs administered
intravenously in experimental animals (17/89). Submitted by Dr. Mazen M. Hasan as a
principal investigator. Supported by the Deanship of Scientific Research and Graduate
Studies, Jordan University of Science and Technology (1989).
3. A bioavailability-bioequivalence study of four preparations of diclofenac sodium (10/88).
Submitted by Dr. Naji M. Najib as a principal investigator. Supported by Dar Al-Dawa
Development and Investment Company, Ltd. (DAD), Na'ur-Jordan (1988).
4. A bioavailability-bioequivalence study of two products contains diclofenac sodium (32/89).
Submitted by Dr. Naji M. Najib as a principal investigator. Supported by the Arab
Pharmaceutical Manufacturing Company, Ltd. (APM), Sult-Jordan (1989).
5. A pharmacokinetic-pharmacodynamic comparison of two products containing glibenclamide
(29/88). Submitted by Dr. Naji M. Najib as a principal investigator. Supported by the Arab
Pharmaceutical Manufacturing Company, Ltd. (APM), Sult-Jordan (1988).
6. Effects of propofol on epileptic activity of hippocampal pyramidal neurons in vitro (7/91).
Submitted by Dr. Zuheir Hasan as a principal investigator (1991). Supported by the
Deanship of Scientific Research and Graduate Studies, Jordan University of Science and
Technology (1991).
7. A bioavailability-bioequivalence study of two products containing famotidine. Submitted by
Dr. Naji M. Najib as the principal investigator. Supported by Dar Al-Dawa Development
and Investment Company, Ltd. (DAD), Na'ur-Jordan (1992).
8. A bioavailability-bioequivalence study on indomethacin and ibuprofen. Submitted by Dr.
Naji M. Najib as a principal investigator. Supported by Dar Al-Dawa Development and
Investment Company, Ltd. (DAD), Na'ur-Jordan (1988)
9. A comparative bioavailability-bioequivalence study on two commercial products containing
glibenclamide (glyburide). Submitted by Dr. Naji M. Najib as a principal investigator.
Supported by Hikma Pharmaceuticals, Amman-Jordan (1994).
10. A bioavailability-bioequivalence study on two cefadroxil- containing products. Submitted by
Dr. Naji M. Najib as the Principal investigator. Supported by the United Pharmaceutical
Company, Ltd., Amman-Jordan (1994).
11. A bioavailability-bioequivalence study on two cefaclor- containing products. Submitted by
Dr. Naji M. Najib as the principal investigator. Supported by Dar Al-Dawa Development
and Investment Company, Ltd. (DAD), Na'ur-Jordan (1994).
12. A bioavailability-bioequivalence study on two omeprazole- containing products. Submitted
by Dr. Naji M. Najib as the principal investigator. Supported by the Arab Pharmaceutical
Manufacturing Company, Ltd. (APM), Sult-Jordan (1994).
13. A bioavailability-bioequivalence study on two anti- hypertensive agents (nifedipine and
atenolol). Submitted by Dr. Naji M. Najib as a principal investigator. Supported by the Arab
Pharmaceutical Manufacturing Company, Ltd. (APM), Sult-Jordan (1994).
13. A bioavailability-bioequivalence study on two lansoprazole-containing products.
Submitted by Dr. Naji M. Najib as a principal investigator. Supported by the Arab
Pharmaceutical Manufacturing Company, Ltd. (APM), Sult-Jordan (1994).
15. A bioavailability-bioequivalence study of two retard products containing diclofenac sodium under
fasting and feeding conditions. N. M. Najib and M. M. Hasan, 1997. Supported by Tabuk
Pharmaceutical Company, Saudi Arabia. 11
16. Effect of anti-epileptic drugs on a novel model of epilepsy. S. Otoom, Kassim Al-Saudi,
and Mazen Hasan. Supported by the Deanship of Scientific Research, Jordan University
of Science and Technology (1997).
17. Current drug use in Jordan. H. Hadidi, A. Bateiha, M. Hasan, and K. Al-Saudi, 2000.
Supported by WHO and Ministry of Health in Jordan (1999).
18. The effect of new antiepileptic drugs on the level of plasma homocysteine. M. Hasan, S.
Otoom, H. Hadidi, and K. Al-Saudi. Submitted to the Deanship of Scientific Research at
JUST for funding (2002).
A.
RESEARCH PRESENATION IN INTERNATIONAL MEETINGS:
1.
Annual Meeting of American Society of Pharmacology and Experimental
Therapeutics (ASPET), Indianapolis, U.S.A.(1984). Graduate Student Travel
Awards from the ASPET Council for the 1984 ASPET Meeting Indianapolis,
Indiana.
2.
Annual Meeting of American Society of Pharmacology and Experimental Therapeutics
(ASPET), Boston, U.S.A. (1985).
3.
Annual Meeting of American Societies for Experimental Biology (FASEB), Saint Louis,
U.S.A. (1986).
4.
Annual Meeting of American Societies for Experimental Biology (FASEB), New
Orleans, U.S.A. (1989).
5.
Annual Meeting of International Congress of Pharmacology, Sydney, Australia (VIIth
Meeting, 1987).
6.
Annual Meeting of International Congress of Pharmacology, Amsterdam, Holland (XI
Meeting, 1990).
7.
International Pharmaceutical Technology Symposium, Ankara, Turkey (4th Symposium, 1988).
8.
The First Gulf Conference on Intensive Care Medicine, Doha, Qatar (1991).
9.
The 5th Interscience World Conference on Inflammation, Antirheumatics, Analgesics,
Immunomodulators (5th INWIN), Geneva (Switzerland), Palexpo (April 25-28, 1993).
10.
The First International Middle East Conference on Pharmaceutical Sciences Jordan
University of Science and Technology, Irbid-Jordan (May 3-5, 1993).
11.
The Thirty Third Scientific Week, Halab-Syria (Nov.6-12,1993).
12.
APGI 7th International Conference on Pharmaceutical Technology. Budapest
(9-11 May,1995).
14.
Proceed. Intern. Symp. Control. Rel. Bioact. Mater., Controlled Release Society,
Inc., Seattle, Washington, U.S.A. (July 30-August 2, 1995).
14.
The VII World Conference on Clinical Pharmacology and Therapeutics (CPT 2000),
Florence-Italy (15-20 July, 2000).
15.
The 3rd Forum of European Neuroscience, Paris-France (13-17 July, 2002).
12
B.
RESEARCH PRESENTED IN THE ANNUAL SCIENTIFIC
DAY OF FACULTY OF MEDICINE AND FACULTY
PHARMACY IN UNIVERSITY OF SCIENCE AND
TECHNOLOGY:
I.
The First Annual Scientific Day (24/4/1987): A study of metaldehyde toxicity and
treatment in mice. M. M. Hasan and P. K. Gessner.
II.
The Second Annual Scientific Day (12/4/1988): Freundlich and Langmuir isotherms as
models for the adsorption of toxicants on activated charcoal. M. M. Hasan and P. K.
Gessner.
III.
The Third Annual Scientific Day (13/5/1989): The effect of oral activated charcoal on
the systemic clearance of gentamicin in rabbits with acute renal failure. M. M. Hasan, Y.
EL-Sayed, and A. Abdelaziz.
IV.
The Fourth Annual Scientific Day (5/5/1990):
1) Effect of oral activated charcoal on the pharmacokinetics of quinidine and
quinine administered intravenously to rabbits. M. M. Hasan, M. A.
Hassan, and N. M. Rawashdeh.
2) Inheritance of sulfate depletion susceptibility in mice. M. M. Hasan and P. K.
Gessner.
V.
The Fifth Annual Scientific Day (30/4/1991): A comparison of the anticonvulsant effects
of propofol and thiopentone against pentylenetetrazol-induced convulsions in the rat.
Zuheir Hasan, Mazen Hasan, AbdelFattah AL-Hader, and Mohammad Takrouri.
VI.
The Sixth Annual Scientific Day (21/4/1992): Effect of propofol on chemically-induced
convulsion. Zuheir Hasan, Mazen Hasan, and AbdelFattah Al-Hader.
VII.
The 14 Annual Scientific Day and the Second Jordanian-Iraqi Congress (10-12 April
2000): Current drug use situation in Jordan. Hakam Hadidi, Anwar Bateiha, Mazen
Hasan, and Kassim Al-Saudi.
SERVICES TO THE COMMUNITY:
I.
Presentation of papers and talks in scientific conferences and meetings:
1. The Fourth Jordanian Pharmaceutical Conference, Amman, 6-8 April, 1988.
"Freundlich
and Langmuir Isotherms as Models for the Adsorption of Toxicants on Activated
Charcoal" Mazen M. Hasan and Peter K. Gessner.
2. A conference on the pathophysiology and drug therapy of bronchial asthma.
Supported by Jordan Pharmaceutical Association in collaboration with Sandoz
Company Irbid, 19 October, 1987 "Drug Therapy in Asthma" Mazen M. Hasan.
3. A scientific day on antibiotics directed by the Faculty of Pharmacy, Jordan University of
Science and Technology, in collaboration with Jordan Pharmaceutical Association, Irbid,
4 Dec., 1987 "Adverse Effects of Antibiotics" Mazen M. Hasan.
13
4. The Third Scientific Day of the Faculty of Pharmacy, University of Jordan, 6
May, 1991 "Effect of Enteric Film Coating on the Bioavailability of Diclofenac
Sodium Tablets" M. Shubair, E. Sallam, N. Najib and M. Hasan.
5. Invited Speaker on "Psychopharmacology". Presented to psychiatry residents,
Fuheis Mental Hospital, Fuheis, 1988.
6.
Invited speaker on "Drug Therapy of Convulsive Disorders". Presented for residents and
medical students, Princes Basma Hospital, Irbid, 1988.
7. Seminar presentation "Therapeutic Implications of the Pharmacokinetics and Dosage
Forms of Diclofenac". Presented to the Faculty of Pharmacy and Medical Sciences,
Amman University, 1997.
I.
Participation in studies dealing with bioequivalence studies on pharmaceutical products
manufactured in Jordan.
II.
Conducting research and publishing papers aiming to improve the pharmaceutical
industry in Jordan.
III.
Teaching pharmacology courses to nursing and midwifery students of Nusayba AlMaziniah College of Nursing and Midwifery in Irbid, Ministry of Health, Jordan.
IV.
External Examiner for two master thesis in analytical toxicology held in Faculty of
Medicine at University of Jordan.
SERVICES TO THE UNIVERSITY AND FACULTY OF MEDICINE:
I. Participation in professional committees as a member:
1.
Organizing Committee of the Scientific Day of the Faculties of Medicine and of
Pharmacy (1986-1994).
2.
Animal House Organizing Committee (1986-1992).
3.
Curriculum Committee of Jordan Universities for Basic Medical Sciences (1988/1989).
4.
Organizing Committee for Medical Student Graduation (1990/1991).
5.
A "Liaison Officer" between Faculty of Medicine and Faculty of Dentistry (1988-1991).
6.
A proposed "National Toxicology Center" (1989/1990).
7.
A workshop on the expansion and improvement of scientific research and graduate
studies (1992).
II.
Taking part to establish the pharmacology and toxicology curricula for different
disciplines.
III.
Taking part in designing and equipping the laboratories for teaching and research in the
Department of Pharmacology.
IV.
Academic guidance of medical and pharmacy students and participation in professional
meetings for education.
14
V.
Director of the "Therapeutic Drug Monitoring and Drug and Toxin Information Unit" at
Princes Basma Hospital.
VI.
A member of the Curriculum Committee in the Medical School
MEMBERSHIP OF PROFESSIONAL SOCIETIES:
1.
A member of Jordan Medical Association (1981-).
2.
A "Honorary Consultant" for Middle East Medical Index (1989-).
3.
A reviewer for two journals (Clinical Drug Investigation and The Annals of
Pharmacotherapy) published by Harvey Whitney Books Company (1992-).
4.
A member of New York Academy of Sciences (1994-).
5.
A member of the National Geographic Society (1996-).
6.
Listed in Who's Who in the World (14th Edition, 1997).
7.
Jordanian Board in Basic Medical Sciences (Pharmacology), Jordan Medical Council,
Amman-Jordan, November 1997.
ABSTRACTS:
1.
Mazen M. Hasan and Peter K. Gessner. D-penicillamine and activated charcoal as
antidotes of metaldehyde toxicity in mice. The Pharmacologist 26: 195 (1984).
2.
Mazen M. Hasan and Peter K. Gessner. Investigation of the role of acetaldehyde in
metaldehyde toxicity in mice. The Pharmacologist 27: 2 (1985).
3.
Peter K. Gessner and Mazen M. Hasan. A study of the adsorption characteristics of
activated charcoals using metaldehyde. The Pharmacologist 27: 273 (1985).
4.
J. Springate, M. Hasan, B. Rennick and M. Acara. Differential inhibition of organic
cations by the renal tubule of the chicken: relationship to Tm. Faseb J. (1985).
5.
Peter K. Gessner and Mazen M. Hasan. Metaldehyde administration leads to sulfate
depletion in the mouse. VIIth International Congress of Pharmacology 0179 (1987).
6.
Mazen M. Hasan and Peter K. Gessner. Freundlich and Langmuir isotherms as models
for the adsorption of toxicants on activated charcoal. Fourth Jord. Pharm. Conf.
(1988).
7.
M. E. Abdel-Hamid, M. S. Suleiman, Y. M. El-Sayed, N. M. Najib and M. M. Hasan. A
rapid HPLC assay of glibenclamide in serum. Fourth International Pharmaceutical
Technology Symposium (1988).
8.
Peter K. Gessner and Mazen M. Hasan. Strain and xenobiotic specific sulfate depletion
phenomena in mice. Faseb J. 3: A 735 (1988).
9.
Peter K. Gessner and Mazen M. Hasan. Inheritance of sulfate depletion
susceptibility in
mice. XIth International Congress of Pharmacology (1990).
15
10.
Zuheir Hasan, Mazen Hasan, AbdelFattah Al-Hader and Mohammad Takrouri.
Anticonvulsant effects of propofol. The First Conference on Intensive Care Medicine
(1991).
11.
M. Hasan, N. Najib, E. Sallam, M. Shubair and S. Deleq. A pharmacokinetic study on
slow-release formulations of diclofenac sodium. The 5th Interscience World
Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators (5th
INWIN 1993).
12.
N. M. Najib and M. M. Hasan. Preparation of sustained-release formulations of
diclofenac sodium. The Thirty Third Scientific Week in Syria (1993).
13.
Mazen M. Hasan and Naji M. Najib. A pharmacokinetic study on slow-release
formulations of diclofenac sodium in Jordan. The First International Middle East
Conference on Pharmaceutical
Sciences (1993).
14.
E. Sallam, M. Shubair, N. Najib and M. Hasan. A critical view on commercially
available diclofenac sodium 50 mg tablets in Jordan. The First International Middle
East Conference on Pharmaceutical Sciences (1993).
15.
E. Sallam, S. Deleq, M. Shubair, N. Najib, M. Hasan, T. Arafat and S. Zemeili. Design
of diclofenac sodium sustained release tablets: in vitro and in vivo studies. The First
International Middle East Conference on Pharmaceutical Sciences (1993).
16.
Y. Tahboub, M. Hasan and N. Najib. Reversed phase liquid chromatographic method for
the determination of famotidine in serum and its use in pharmacokinetics. The First
International Middle East Conference on Pharmaceutical Sciences (1993).
17.
H. Y. Muti, M. M. Hasan and N. M. Najib. A pharmacokinetic study on two sustainedrelease formulations of indomethacin in normal subjects following a single dose
administration. The Seventh Jord. Pharm. Conf. (1994).
18.
N. M. Najib, M. M. Hasan and I. M. Jalal. Bioavailability of amoxicillin from capsules
and tablets. Submitted to American Association of Pharmaceutical Scientists (1994).
19.
N. M. Najib, G. K. Pillai, M. Sheikh Salem, M. M. Hasan, F. Ghanem, E. Sallam, M. S.
Shubair, and S. Al-Deleq. Bio-equivalence study of two capsule formulations of
omeprazole. Proc. 1st. World Meeting APGI/APV, Budapest, 9/11 May (1995).
20.
E. Sallam, S. Al-Deleq, M. Shubair, S. Zemeili, M. Hasan, N. Najib, and T. Arafat.
Design of diclofenac sodium 100 mg sustained release tablets, in vitro and in vivo
studies. Proc. 1st Word Meeting APGI/APV, Budapest, 9/11 May (1995).
21.
E. Sallam, S. Al-Deleq, M. Shubair, S. Zemeili, M. Hasan and N. Najib. Dose
strength bioavailability relationship of enteric coated SR diclofenac sodium
tablets. Intern. Symp. Control. Rel. Bioact. Mater., 22 (1995).
22.
S. Otoom, M. Hasan, K. Al-Saudi, and H. Hadidi. The VII World Conference on
Clinical Pharmacology and Therapeutics (CPT), Florence-Italy 15-20 July, 2000.
Published in: British Journal of Clinical Pharmacology (707: 181, 2000).
23.
S. Otoom, M. Nusier, M. Hasan, H. Hadidi, R. Samawi, A. Younes, M.
Darweesh, and N. Boulatova. The association of polycystic ovaries with the use
of valproate in epilepsy. European Journal of Clinical Pharmacology, 2001.
Submitted to the Umea Summer International Conference of Adverse Drug
Reactions, Umea 13-15 June, 2001, Sweden.
16
24.
S. Otoom, M. Hasan, and M. Najib. Pharmacokinetics of glyburide under feeding
and fasting conditions. Therapeutic Drug Monitoring, 2001. Submitted to the
International Congress of Therapeutic Drug Monitoring and Toxicology,
Washington, 1-5 September, USA.
25.
S. Otoom, H. Hadidi, and M. Hasan. Propofol Exhibits antiepileptic activity in
hippocampal pyramidal neurons. Submitted to the 3rd Forum of European Neuroscience,
July 13-17, 2002, Paris-France.
REPORTS:
1.
A bioavailability-bioequivalence study of two conventional products of
diclofenac sodium. N. M. Najib, M. S. Suleiman, Y. M. El-Sayed, M. Hasan, and
M. Abdel-Hamid, 1988. A report submitted to Dar Al-Dawa Development and
Investment Co. Ltd. (DAD), Jordan.
2.
A bioavailability-bioequivalence study of two formulations containing glibenclamide.
N. M. Najib, M. S. Suleiman, Y. El-Sayed, M. Abdel-Hamid, and M. Hasan, 1989. A
report submitted to the Arab Pharmaceutical Manufacturing Company Ltd. (APM),
Jordan.
3.
A bioavailability-bioequivalence study of two conventional products of diclofenac
sodium. N. M. Najib and M. M. Hasan, 1990. A report submitted to The Arab
Pharmaceutical Manufacturing Company Ltd. (APM), Jordan.
4.
A bioavailability-bioequivalence study of two sustained- release formulations of
diclofenac sodium. N. M. Najib and M.M. Hasan, 1992. A report submitted to Dar AlDawa Investment and Development Co., Ltd. (DAD), Jordan.
5.
A bioavailability-bioequivalence study of two sustained- release formulations of
diclofenac sodium. N. M. Najib and M.M. Hasan, 1992. A report submitted to Hikma
Pharmaceuticals, Jordan.
6.
A two-way crossover bioequivalence study comparing single dose of Hikma 1000 mg
amoxicillin tablets (Penamox, lot # 0058) to Beecham Laboratories 2 X 500 mg Amoxil
capsules (lot # 37219A). N. M. Najib and M. M. Hasan, 1993. A report submitted to
Hikma Pharmaceuticals, Jordan.
7.
A bioavailability-bioequivalence study of two conventional products containing
ibuprofen. N. M. Najib and M. M. Hasan,1993. A report submitted to Dar Al-Dawa
Development and Investment Company, Ltd. (DAD) in Jordan.
8.
A bioavailability-bioequivalence study of two sustained- release formulations of
indomethacin. N. M. Najib and M. M. Hasan, 1993. A report submitted to Dar Al-Dawa
Investment and Development Co., Ltd. (DAD).
9.
A bioavailability-bioequivalence study of two products containing cefadroxil. N. M.
Najib and M. M. Hasan, 1994. A report submitted to The United Pharmaceutical
Company, Ltd., Jordan.
10.
A bioavailability-bioequivalence study of two products containing cefaclor. N. M. Najib
and M. M. Hasan, 1994. A report submitted to Dar Al-Dawa Development and
Investment Company, Ltd. (DAD), Jordan.
17
11.
A two-way crossover bioequivalence study comparing single dose of Hikma 5 mg
glibenclamide (glyburide) tablets (Glibil, batch # 4686) to Hoechst 5 mg tablets (Daonil,
batch # 1240). N. M. Najib and M. M. Hasan, 1994. A report submitted to Hikma
Pharmaceuticals, Jordan.
12.
A two-way crossover bioequivalence study comparing single dose of Hikma 5 mg
glyburide (glibenclamide) tablets (Glibil, batch # 4686) to Hoechst 5 mg tablets (Daonil,
batch # 1240) carried out postprandially. N. M. Najib and M. M. Hasan, 1994. A report
submitted to Hikma Pharmaceuticals, Jordan.
13.
A bioavailability-bioequivalence study of two sustained- release formulations of
diclofenac sodium. N. M. Najib and M. M. Hasan, 1994. A report submitted to The
United Pharmaceutical Company, Ltd., Jordan.
14.
A bioavailability-bioequivalence study of two conventional formulations of piroxicam.
N. M. Najib, M. M. Hasan, and M. S. Salem, 1994. A report submitted to The United
Pharmaceutical Company, Ltd., Jordan.
15.
Bioavailability-bioequivalence studies of several sustained-release formulations of
diclofenac sodium under fasting and feeding conditions. N. M. Najib and M. M. Hasan,
1994. A report submitted to The Arab Pharmaceutical Manufacturing Company., Ltd.
(APM), Jordan.
16.
A bioavailability-bioequivalence study of two suppository products of diclofenac
sodium. N. M. Najib and M. M. Hasan, 1994. A report submitted to The Arab
Pharmaceutical Manufacturing Company., Ltd. (APM), Jordan.
17.
A bioavailability-bioequivalence study of two suppository products of diclofenac sodium.
Najib and M. M. Hasan,1994. A report submitted to Hikma Pharmaceuticals, Jordan.
18.
A bioavailability-bioequivalence study of two capsule products of omeprazole under
fasting and feeding conditions. N. M. Najib, M. S. Salem, M. M. Hasan, and G. K. Pillai
1994. A report submitted to The Arab Pharmaceutical Manufacturing Company, Ltd.
(APM), Jordan.
19.
A bioavailability-bioequivalence study of two conventional formulations of ranitidine.
N. M. Najib and M. M. Hasan,1994. A report submitted to The United Pharmaceutical
Company, Ltd., Jordan.
20.
A bioavailability-bioequivalence study of two conventional formulations of famotidine.
N. M. Najib and M. M. Hasan, 1994. A report submitted to Hikma Pharmaceuticals,
Jordan.
21.
A bioavailability-bioequivalence study of two conventional formulations of famotidine.
N. M. Najib and M. M. Hasan,1994. A report submitted to Dar Al-Dawa Development
and Investment Company, Ltd. (DAD), Jordan.
22.
A bioavailability-bioequivalence study of two conventional products of nifedipine. N.
M. Najib and M. M. Hasan, 1995. A report submitted to The Arab Pharmaceutical
Manufacturing Company Ltd. (APM), Jordan.
23.
A bioavailability-bioequivalence study of two conventional products of atenolol. N. M.
Najib and M. M. Hasan, 1995. A report submitted to The Arab Pharmaceutical
Manufacturing Company, Ltd. (APM), Jordan.
18
24.
A bioavailability-bioequivalence study of two conventional tablets of ciprofloxacin. N.
M. Najib and M. M. Hasan, 1995. A report submitted to Hikma Pharmaceuticals, Jordan.
25.
A bioavailability-bioequivalence study of two conventional tablets of loratadine. N. M.
Najib and M. M. Hasan, 1995. A report submitted to Hikma Pharmaceuticals, Jordan.
26.
A bioavailability-bioequivalence study of two capsule products containing a
combination of amoxicillin and clavulanic acid. N. M. Najib and M. M. Hasan, 1995. A
report submitted to Hikma Pharmaceuticals, Jordan.
27.
A bioavailability-bioequivalence study of two suspension products containing a
combination of amoxicillin and clavulanic acid. N. M. Najib and M. M. Hasan, 1995. A
report submitted to Hikma Pharmaceuticals, Jordan.
28.
A bioavailability-bioequivalence study of two products containing cefadroxil. N.
M. Najib and M. M. Hasan, 1996. A report submitted to Tabuk Pharmaceutical
Company, Saudi Arabia.
29.
A bioavailability-bioequivalence study of two products containing a combination of
phenylpropanolamine HCl and chlorpheniramine maleate. N. M. Najib, M. S. Salem,
and M.M. Hasan, 1996. A report submitted to The Arab Pharmaceutical Manufacturing
Company, Ltd. (APM), Jordan.
30.
A bioavailability-bioequivalence study of two capsule products of lansoprazole under
fasting and feeding conditions. N. M. Najib and M. M. Hasan, 1996. A report submitted
to The Arab Pharmaceutical Manufacturing Company, Ltd. (APM), Jordan.
31.
A bioavailability-bioequivalence study of two retard products containing diclofenac
sodium under fasting and feeding conditions. N. M. Najib and M. M. Hasan, 1997. A
report submitted to Tabuk Pharmaceutical Company, Saudi Arabia.
32.
Current drug use in Jordan. H. Hadidi, A. Bateiha, M. Hasan, and K. Al-Saudi, 2000. A
study submitted to the Ministry of Health in Jordan.
PUBLICATIONS:
1.
Peter K. Gessner and Mazen M. Hasan. Potentiation of acute
toxicity of
2-Sec-butylphenyl N-methylcarbamate by fenthione in mice. Fund. Appl. Toxicol. 6:
381-383 (1986).
2.
Peter K. Gessner and Mazen M. Hasan. The Freundlich and Langmuir isotherms as
models for the adsorption of toxicants on activated charcoal. J. Pharm. Sci. 67: 319-327
(1987).
3.
Peter K. Gessner and Mazen M. Hasan. Toxicant adsorption on activated charcoal: Is
the fraction adsorbed a unique function of the charcoal: adsorbate ratio. J. Pharm. Sci.
76: 707-710 (1987).
4.
J. Springate, M. Hasan, B. Rennick, R. Fildes, L. Feld and M. Acara. Relation between
transport maxima and inhibition of organic cation excretion in the chicken kidney. J.
Pharmacol. Exp. Therap. 240(2): 400-403 (1987).
5.
Yousry El-Sayed, Mohammad S. Suleiman, Mazen M. Hasan, Naji Najib, Hassan Muti
and Mohammad Abdel-Hamid. Comparative bioavailability and in vitro characterization
of two brands of diclofenac sodium enteric-coated tablets. Int. J. Clin. Pharmacol.
Therap. Toxicol. 26: 487-491 (1988).
19
6.
Yousry M. El-Sayed, Mohammad S. Suleiman, Mazen M. Hasan, Mohammad E.
Abdel-Hamid, Naji Najib, El-Sayed E. Sallam and Mohammed S. Shubair. Comparison
of the pharmacokinetics and pharmacodynamics of two commercial products containing
glibenclamide. Int. J. Clin. Pharmacol. Therap. Toxicol. 27: 551-557 (1989).
7.
Hani D. Tabba, Mohammed E. Abdel-Hamid, Mohammad S. Suleiman, Mohammad M. Al-Arab,
Mazen M. Hasan, Saleh Abu-Lafi and Naji M. Najib. Synthesis, identification and preliminary
evaluation of esters and amide derivatives of diflunisal. Int. J. pharm.54: 57-63 (1989).
8.
Mohammed E. Abdel-Hamid, Mohammad S. Suleiman, Yousry M. El-Sayed, Naji M.
Najib and Mazen M. Hasan. A rapid high performance liquid chromatography assay of
glibenclamide in Serum. J. Clin. Pharm. Therap. 14: 181-188 (1989).
9.
Mohammad Suleiman, Yousry El-Sayed, Naji Najib, Mazen Hasan and Mohammed
Abdel-Hamid. A Study on the relative bioavailability of a sustained release formulation
of diclofenac sodium. Int. J. Clin. Pharmacol. Therap. Toxicol. 27: 276-279 (1989).
10.
M. M. Hasan, Y. M. El-Sayed and A. A. Abdelaziz. The effect of oral activated charcoal
on the systemic clearance of gentamicin in rabbits with acute renal failure. J. Pharm.
Pharmacol. 42: 85-88 (1990).
11.
Y. M. El-Sayed and M. M. Hasan. Enhancement of morphine clearance following intravenous
administration by oral activated charcoal in rabbits. J. Pharm. Pharmacol. 42: 538-541 (1990).
12.
M. M. Hasan, M. A. Hassan and N. M. Rawashdeh. Effect of oral activated charcoal on
the pharmacokinetics of quinidine and quinine administered intravenously to rabbits.
Pharmacol. Toxicol. 67: 73-76 (1990).
13.
M. M. Hasan, N. M. Najib, N. M. Rawashdeh, E. N. Sallam, M. S. Shubair and Y.
Alawneh. Comparative bioavailability of two tablet formulations of diclofenac sodium in
normal subjects. Int. J. Clin. Pharmacol. Therap. Toxicol. 29: 178-183 (1991).
14.
Zuheir Hasan, Mazen Hasan, AbdelFattah Al-Hader and Mohammad Takrouri. A
comparison of the anticonvulsant effects of propofol and thiopentone against
pentylenetetrazol-induced convulsions in the rat. Clin. Exp. Pharmacol. Physiol. 18:
691-695 (1991).
15.
M. Hasan, N. Najib, M. Suleiman, Y. El-Sayed and M. Abdel-Hamid. In vitro and in
vivo evaluation of sustained release and enteric-coated microcapsules of diclofenac
sodium. Drug Develop. Indust. Pharm. 18: 1981-1988 (1992).
16.
Zuheir A. Hasan, Mazen M. Hasan, AbdelFattah A. Al-Hader and Mohammad S.
Takrouri. The effect of propofol and thiopentone on pentylenetetrazol seizure threshold
in the rat. Middle East J. Anesthesiology 11: 359-367 (1992).
17.
AbdelFattah Al-Hader, Mazen Hasan and Zuheir Hasan. The comparative effects of
propofol, thiopentone and diazepam, administered intravenously, on pentylenetetrazol
seizure threshold in the rabbit. Life Sci. 51: 779-786 (1992).
18.
Mazen Hasan, Zuheir Hasan and AbdelFattah Al-Hader. The anticonvulsant effects of
propofol, diazepam, and thiopental, against picrotoxin-induced seizure in the rat. Middle
East J. Anesthesiology 12: 113-121 (1993).
19.
Mazen M. Hasan, Naji M. Najib and Hasan Muti. A comparative bioavailability study
on two sustained-release formulations of diclofenac sodium following a single dose
administration. Int. J. Clin. Pharmacol. Therap. Toxicol. 31: 387-391 (1993).
20
20.
M. M. Hasan, N. M. Najib and H. Y. Muti. A pharmacokinetic study on two sustainedrelease formulations of indomethacin in normal subjects following a single dose
administration. J. Clin. Pharm. Therap. 19: 295-299 (1994).
21.
S. Zemeili, M. Hasan, N. Najib, E. Sallam, S. Deleq and M. Shubair. Bioavailability and
pharmacokinetic properties of 2 sustained-release formulations of enteric diclofenac
sodium, Voltaren vs Inflaban: effect of food on Inflaban bio- availability. Int. J. Clin.
Pharmacol. Therap. 34: 564-570 1996).
22.
G. K. Pillai, M. Sheikh Salem, N. M. Najib, J. Jilani, M. M. Hasan, E. Ghanem, E.
Sallam, M. S. Shubair, and S. Al- Deleq. Bioequivalence study of two capsule
formulations of omeprazole. Acta Pharmaceutica Hungarica 66: 231-235 (1996).
23.
M. M. Hasan, J. A. Jilani, M. S. Salem, N. M. Najib, G. K. Pillai, E. Ganem.
Bioequivalence of two capsule formulations of piroxicam. Acta Pharmaceutica
Turcica XXXIX (3): 93-97 (1997).
24.
Nasir M. Idkaidek, Gordon L. Amidon, David E. Smith, N. M Najib, and M. M. Hasan.
Determination of the population pharmacokinetic parameters of sustained release and
enteric coated oral formulations, and the suppository formulation of diclofenac sodium
by simultaneous data fitting NONMEM. Biopharmaceutics and Drug Disposition 19:
169-174 (1998).
25.
J. A. Jilani, N. M. Najib, M. S. Salem, G. K. Pillai M. M. Hasan, F. M. Zghol, and E.
Ghanem. and I. Jalal. High performance liquid chromatography determination of
loratadine in human plasma using fluorescence detection. Acta Pharmaceutica Turcica
XXXX (3): 99-102 (1998).
26.
S. Khatib, A. Alkofahi, M. Hasan and N. Najib. The cardiovascular effects of
Rosmarinus officinalis extract on the isolated intact rabbit heart. Fitoterapia LXIX No
6: 502-506 (1998).
27.
S. Khatib, A. Alkofahi, M. Hasan, N. Najib, and A. El-oqlah. The Effect of Corchorus
olitorius seed extract on left ventricular pressure, coronary flow and heart rate of the
isolated intact rabbit heart. Biomedical Letters 57: 147-152 (1998).
28.
G. K. Pillai, M. M. Hasan, M. Sheikh Salem, and N. M. Najib. Effect of food on the
bioavailability of omeprazole. International Journal of Pharmaceutical Medicine 12:
199-202 (1999).
29.
Zuheir A. Hasan, Mazen M. Hasan, Kassim Karim, and D. E. Wooley. Effect of
propofol and thiopentone on pilocarpine-induced limbic seizures in the rat.
Biomedical Letters 60: 55-63 (1999).
30.
S. Otoom, M. Hasan, and N. Najib. The bioavailability of glyburide
(glibenclamide) under fasting and feeding conditions: a comparative study.
International Journal of Pharmaceutical Medicine 15: 117-120 (2001).
31.
S. Otoom, A. Batieha, H. Hadidi, M. Hasan, and K. Al-Saudi. Evaluation of drug
use in Jordan using WHO prescribing indicators. IEMHJ 8 (4/5): 537-543
(2002).
32.
S. Otoom, A. Batieha, H. Hadidi, M. Hasan, and K. Al-Saudi. Evaluation of
drug use in Jordan using WHO patient care and health facility indicators.
IEMHJ 8 (4/5): 544-549 (2002).
21
33.
Otoom S, Nusier M, Hasan M, Hadidi H, Samawi R, Younes AM, Darweesh M,
and Boulatova NR. The association of polycystic ovaries with use of valproate
in Jordanian epileptic patients. Clin. Drug Invest. 23 (8): 527-532 (2003).
34.
Otoom, S., Hasan, M., and Najib, N. Comparative bioavailability of two cefadroxil
products using serum and urine data in healthy human volunteers. Clinical and
Experimental Pharmacology and Physiology 31: 433-437 (2004).
35.
Hasan, M, Otoom, S., Najib, N., and Sallam, E.-S. A two-way cross-over
bioequivalence study comparing two products of diclofenac sodium
suppositories in healthy human volunteers. Basic and Clinical
Pharmacology and Toxicology (2004).
22