A. fumigatus A. nidulans C. glabrata C. albicans S. cerevisiae S. pombe msi2 SPCP1E11.10 lig4 pho84 bfr1 fhn1 SPBC1683.01 plb1 SPAC513.07 sua1 atd1 adh8 hsp3101 hal4 str1 tco1 pmc1 psp3 pof9 rga5 pas1 SPAC5D6.04 imt2 SPBC1198.07c pun1 pmp31 SPAC9G1.10c pmr1 SPAC23D3.12 frp1 cmk1 imt1 SPBC21B10.07 fur4 bgs1 SPAC25B8.09 SPAC19G12.09 prz1 SPAC18B11.03c SPBC19C7.05 gas2 SPCC794.03 ght6 hsp3102 Positively regulated Negatively regulated Figure S2 The orthologs of the 339 differentially regulated genes in S. pombe that are regulated by a Prz1 ortholog in other fungal species. The highest number of orthologs is found between S. pombe and S. cerevisiae. This is likely due to several factors including the closer evolutionary distance. The other factors include the better characterized ortholog list between S. pombe and S. cerevisiae as well as the greater number of experiments and conditions used to find Crz1 targets in S. cerevisiae compared to the other species included.