Rebecca Ellis Dutch
Department of Molecular and Cellular Biochemistry
University of Kentucky College of Medicine
741 South Limestone; Biomedical Biological Science Building
Lexington, KY 40536-0509
Phone: (859)323-1795
e-mail: rebecca.dutch@uky.edu
Research Career:
Associate Dean for Biomedical Education, University of Kentucky College of Medicine
Appointment date: October 1, 2013
Professor, Department of Molecular and Celular Biochemistry, University of Kentucky
Appointment date: July 1, 2011
Associate Professor, Department of Molecular and Cellular Biochemistry, University of Kentucky
Appointment date: July 1, 2006
Assistant Professor, Department of Molecular and Cellular Biochemistry, University of Kentucky
Appointment date: July 1, 2000
Postdoctoral Scholar, Howard Hughes Medical Institute/Northwestern University, 1995-2000
Advisor: Dr. Robert A. Lamb
Postdoctoral Scholar, Department of Biochemistry, Stanford University, 1994
Advisor: Dr. I. Robert Lehman
Graduate Student, Department of Biochemistry, Stanford University, 1987-1993
Advisor: Dr. I. Robert Lehman
Degree: Ph.D., granted 1994
Graduate Student, Department of Biochemistry, Cambridge University, 1986-1987
Advisor: Dr. D. H. Northcote
Degree: M.Phil., granted 1987
Undergraduate Student, Michigan State University, 1982-1986
Research Advisors: Dr. Shelagh Ferguson-Miller and Dr. William W. Wells
Degrees: B.S. Biochemistry and B.S. Microbiology
Scholarships and Fellowships:
NIH NRSA Postdoctoral Fellowship, 1996-1999
Katherine McCormick Fund for Women Scholarship, 1992
NSF Predoctoral Fellowship, 1987-1990
Winston Churchill Scholarship, 1986-1987
Phi Kappa Phi Chapter Scholarship, 1986
Michigan State University Alumni Distinguished Scholarship, 1982-1986
National Merit Scholarship, 1982
Honors:
Finalist, Provost Outstanding Teacher Award, University of Kentucky, 2008, 2009
Nominee, Sarah Bennett Holmes Award, University of Kentucky, 2007, 2010, 2011, 2012
University of Kentucky Nominee, Ellison Medical Foundation New Scholar Award in Global Infectious
Diseases, 2003
University of Kentucky Nominee, Burroughs Wellcome Fund New Investigator in the Pharmacological
Sciences, 2000
Michigan State University Board of Trustee's Award (five highest GPAs in graduating class), 1986
Commencement speaker, College of Natural Science, Michigan State University, 1986
Outstanding Undergraduate Award, Department of Biochemistry, Michigan State, 1986
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Rebecca Ellis Dutch
Outstanding Undergraduate Award, Department of Microbiology, Michigan State, 1986
Phi Beta Kappa Membership, Phi Kappa Phi Membership, 1985
Publications:
Publications on Research at the University of Kentucky
El Najjar, Farah, Levi Lampe, Michelle Baker, Linfa Wang and Rebecca Ellis Dutch. (2105) Analysis
of cathepsin and furin proteolytic enzymes in viral fusion protein activiation of the bat reservoir host.
PloS One. 10(2):e0115736.
El Najjar, Farah, Anthony P. Schmitt and Rebecca Ellis Dutch (2014) Paramyxovirus glycoprotein
incorporation, assembly and budding: A three way dance for infectious particle production. Viruses: 6:
3019-3054. Invited Research Review.
Masante, Cyril, Farah El Najjar, Andres Chang and Rebecca Ellis Dutch. (2014) The HMPV small
hydrophobic protein has properties consistent with a viroporin and can modulate viral fusogenic activity.
J. Virology 88: 642306433. Highlighted by the Journal Editors.
Amarasinghe, G. K. and Rebecca Ellis Dutch (2014) A calcium-fortified viral matrix protein. Structure
22: 5-7. Invited Commentary.
Smith, Everett Clinton, Stacy E. Smith, James R. Carter, Stacy R. Webb, Kathleen M. Gibson, Lance M.
Hellman, Michael G. Fried and Rebecca Ellis Dutch (2013) Trimeric transmembrane domain
interactions in paramyxovirus fusion proteins: potential roles in protein folding, stability and function.
JBC 288: 35726-35.
Chang, Andres and Rebecca Ellis Dutch (2012). Paramyxovirus fusion and entry: multiple paths to a
common end. Viruses 4(4), 613-36.
Chang, Andres, Brent A. Hackett, Christine C. Winter, Ursula J. Buchholz and Rebecca Ellis Dutch
(2012). Potential electrostatic interactions in multiple regions affect human metapneumovirus Fmediated membrane fusion. J Virol 86(18), 9843-53. Highlighted by Faculty of 1000.
Chang, Andres, Cyril Masante, Ursula J. Buchholz, and Rebecca Ellis Dutch (2012). Human
metapneumovirus (HMPV) binding and infection are mediated by interactions between the HMPV
fusion protein and heparan sulfate. J Virol 86(6), 3230-43. Highlighted by Faculty of 1000.
Popa, Andreea, James R. Carter, Stacy E. Smith, Lance Hellman, Michael G. Fried, and Rebecca Ellis
Dutch (2012). Residues in the Hendra virus fusion protein transmembrane domain are critical for
endocytic recycling. J Virol 86(6), 3014-26.
Smith, Everett C., Megan R. Culler., Lance M. Hellman, Michael G.Fried, Trevor P. Creamer, and
Rebecca Ellis Dutch (2012). Beyond anchoring: the expanding role of the Hendra virus F protein
transmembrane domain in protein folding, stability and function. J Virol 86, 3003-13.
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Rebecca Ellis Dutch
Publications on Research at the University of Kentucky (con.):
Smith, Everett C., Sonia M. Gregory, Lukas K. Tamm, Trevor P. Creamer, and Rebecca Ellis Dutch
(2012). Role of sequence and structure of the hendra fusion protein fusion Peptide in membrane fusion. J
Biol Chem 287(35), 30035-48.
Popa, Andreea, Cara Teresia Pager and Rebecca Ellis Dutch. (2011) C-terminal tyrosine residues
modulate the fusion activity of the Hendra virus fusion protein. Biochemistry 50: 945-952.
Smith, Everett C. and Rebecca Ellis Dutch (2010) Side chain packing below the fusion peptide strongly
modulates triggering of the Hendra F protein. J. Virol. 84: 10928 – 10932.
Dutch, Rebecca Ellis (2010) Entry and fusion of emerging paramyxoviruses. PLoS Pathog. Jun
24;6(6):e1000881. Invited Research Review.
Wurth, Mark A., Rachel M. Schowalter, Everett C. Smith, Carole L. Moncman, Rebecca Ellis Dutch*,
and Richard O. McCann. (2010) The actin cytoskeleton inhibits pore expansion during PIV5 fusion
protein-promoted cell-cell fusion. Virology 404: 117-126. *Corresponding author
Smith, Everett C., Andreea Popa, Andres Chang, Cyril Masante and Rebecca Ellis Dutch. (2009) Viral
entry mechanisms: the increasing diversity of paramyxovirus entry. FEBS J. 276: 7217-7227. Invited
Research Review.
Schowalter, Rachel M., Andres Chang, Jessica G. Robach, Ursula J. Buchholz and Rebecca Ellis
Dutch, (2009) Low pH triggering of human metapneumovirus fusion: essential residues and importance
in entry. J. Virol.. 83: 1511-1522.
Whitman, Shannon D., Everett C. Smith and Rebecca Ellis Dutch (2009) Differential rates of protein
folding and cellular trafficking for the Hendra F and G proteins: Implications for F-G complex
formation. J. Virol. 83: 8998-9001.
Gardner, Amanda and Rebecca Ellis Dutch (2007) A conserved region within the F2 subunit of
paramyxovirus fusion proteins is involved in fusion regulation. J. Virol. 81: 8303-8314.
Gardner, Amanda, Kimberly Martin and Rebecca Ellis Dutch (2007) A conserved region between the
heptad repeats of paramyxovirus fusion proteins is critical for F protein folding. Biochemistry 46: 50945105.
Whitman, Shannon D. and Rebecca Ellis Dutch (2007) The surface density of the Hendra G protein
modulates Hendra F promoted cell-cell fusion. Virology 363: 419-425.
Schowalter, Rachel M., Stacy E. Smith, and Rebecca Ellis Dutch (2006) Characterization of human
metapneumovirus F protein-promoted membrane fusion: critical roles for F protein processing and low
pH. J. Virol. 80:10931-10941.
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Rebecca Ellis Dutch
Publications on Research at the University of Kentucky (con.):
Pager, Cara T., Willie W. Craft, Jr., Jared Patch and Rebecca Ellis Dutch (2006) A mature and
fusogenic form of the Nipah virus fusion protein requires proteolytic processing by cathepsin L.
Virology. 346: 251-257.
Schowalter, Rachel M., Mark A. Wurth, Hector C. Aguilar, Benhur Lee, Carole L. Moncman, Richard
O. McCann and Rebecca Ellis Dutch (2006) Rho GTPase activity modulates paramyxovirus F protein
mediated cell-cell fusion. Virology. 350: 323-334 (COVER).
Meulendyke, Kelly A., Mark A. Wurth, Richard O. McCann and Rebecca Ellis Dutch (2005)
Endocytosis plays a critical role in proteolytic processing of the Hendra virus fusion protein. J. Virol.
79: 12643-12649.
Pager, Cara T. and Rebecca Ellis Dutch (2005) Cathepsin L is involved in proteolytic processing of the
Hendra virus fusion protein. J. Virol. 79: 12714-12720.
Craft, Willie W. and Rebecca Ellis Dutch (2005) Sequence motif upstream of the Hendra virus fusion
protein cleavage site is not sufficient to promote efficient proteolytic processing. Virology. 341: 130140.
Carter, James, Stephen D. Fowler, Cara T. Pager and Rebecca Ellis Dutch (2005) The role of N-linked
glycosylation of the Hendra virus fusion protein. J. Virol. 79:7922-7925.
West, Dava S., Michael S. Sheehan, Patrick K. Segeleon and Rebecca Ellis Dutch. (2005) Role of Nterminal heptad repeat residues in the folding and membrane fusion promotion of the SV5 F protein. J.
Virol. 79: 1543-1551.
Pager, Cara T., Mark A. Wurth and Rebecca Ellis Dutch (2004) Sub-cellular localization and
determination of Ca2+ and pH requirements for proteolytic cleavage of the Hendra virus fusion protein.
J. Virol. 78: 9154-9163.
Book Chapters at University of Kentucky
Melikian, Gregory G., Everett C. Smith and Rebecca E. Dutch. (2012) Mechanisms of enveloped virus
entry by membrane fusion in Comprehensive Biophysics, Vol. 5 Membranes, Editor-in-Chief Edward
H. Engelman, Editor Lukas Tamm. Elsevier. 290-311.
Schowalter, Rachel M. and Rebecca Ellis Dutch, (2011) Virus-cell fusion, pages 241- 260, in Structural
Virology, Royal Society of Chemistry. Editors M. Agbandje-McKenna and R. McKenna.
Dutch, R. E. (2008) Paramyxoviruses in: Encyclopedia of Virology, Third Edition, vol. 4: pp 52-57.
Publications on Previous Research
Dutch, Rebecca Ellis and Robert A. Lamb (2001) Deletion of the cytoplasmic tail of the fusion (F)
protein of paramyxovirus simian virus 5 (SV5) affects fusion pore enlargement. J. Virol. 75: 53635369.
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Rebecca Ellis Dutch
Publications on Previous Research(con.)
Dutch, Rebecca Ellis, Ryan N. Hagglund, Margaret A. Nagel, Reay G. Paterson and Robert A. Lamb.
(2001) Paramyxovirus fusion (F) protein: A conformational change on cleavage-activation. Virology
281: 138-150
Dutch, Rebecca Ellis, Theodore S. Jardetsky and Robert A. Lamb. (2000) Virus membrane fusion
proteins: Biological machines that undergo a metamorphosis. Bioscience Reports 20: 597-612.
Baker, Kent A., Rebecca Ellis Dutch, Robert A. Lamb, and Theodore S. Jardetzky. (1999) Structural
basis for paramyxovirus-mediated membrane fusion. Molecular Cell 3: 309-319.
Dutch, Rebecca Ellis, George P. Leser, and Robert A. Lamb. (1999) Paramyxovirus fusion protein:
characterization of the core trimer, a rod-shaped complex with helices in anti-parallel orientation.
Virology 254: 147-159.
Lamb, R.A., Sangeeta Bagai Joshi, and Rebecca Ellis Dutch. (1999) The paramyxovirus fusion protein
forms an extremely stable core trimer: structural parallels to influenza virus haemagglutinin and HIV-1
gp41. Mol. Memb. Biol. 16: 11-19.
Joshi, Sangeeta Bagai, Rebecca Ellis Dutch, and Robert A. Lamb. (1998) A core trimer of the
paramyxovirus fusion protein: parallels to influenza virus hemagglutinin and HIV-1 gp41. Virology 248:
20-34.
Dutch, Rebecca Ellis, Sangeeta Bagai Joshi, and Robert A. Lamb. (1998) Membrane fusion promoted
by increasing surface densities of the paramyxovirus F and HN proteins: comparison of fusion reactions
mediated by simian virus 5 F, human parainfluenza virus type 3 F, and influenza virus HA. J. Virol. 72:
7745-7753.
Zhou, Jie, Rebecca Ellis Dutch, and Robert A. Lamb. (1997) Proper spacing between heptad repeat B
and the transmembrane domain boundary of the paramyxovirus SV5 F protein is critical for biological
activity. Virology. 239: 327-339.
Dutch, Rebecca Ellis, Vera Bianchi, and I. R. Lehman. (1995) Herpes simplex virus type 1 DNA
replication is specifically required for high frequency homologous recombination between repeated
sequences. J. Virol. 69: 3084-3089.
Dutch, Rebecca Ellis, Boris V. Zemelman, and I. R. Lehman. (1994) Herpes simplex virus type 1
recombination: the Uc-DR1 region is required for high level a sequence mediated recombination. J.
Virol. 68:3733-3741.
Dutch, Rebecca Ellis and I. R. Lehman. (1993) Renaturation of complementary DNA strands by herpes
simplex virus 1 ICP8. J. Virol. 67: 6945-6949.
Bruckner, Robert C., Rebecca Ellis Dutch, Boris V. Zemelman, Edward S. Mocarski, and I.R. Lehman.
(1992) Recombination in vitro between herpes simplex virus type 1 a sequences. Proc. Natl. Acad. Sci.
USA 89: 10950-10954.
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Rebecca Ellis Dutch
Publications on Previous Research(con.)
Dutch, Rebecca Ellis, Robert C. Bruckner, Edward S. Mocarski, and I. R. Lehman. (1991) Herpes
simplex virus 1 recombination: role of DNA replication and viral a sequences. J. Virol. 66: 277-285
Hernandez, Thomas R., Rebecca Ellis Dutch, I. R. Lehman, Claes Gustafsson, and Per Elias. (1991)
Mutations in a herpes simplex virus type 1 origin that inhibit interaction with origin-binding protein also
inhibit DNA replication. J. Virol. 65:1649-1652.
Previous Book Chapter
Dutch, R., R. Ingle, J. Centeno, W. Peiffer, G. Babcock, and S. Ferguson-Miller. (1987) Cytochrome
oxidase from etiolated corn seedlings, in Plant Mitochondria, 301-304. A.L. Moore and R.B. Beechey,
eds. Plenum Press, New York.
Research Grants (Active):
“Paramyxovirus F protein-promoted membrane fusion”
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R01, January 2015 – December 2019
“Hendra virus trafficking and assembly”
Principal Investigators (multi-PI with Schmitt): Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R21, February 2014 – January 2016
REU Site: Summer program in the biochemical sciences
Co-Principal Investigator: Rebecca Ellis Dutch
Agency: National Science Foundation
Type: Training grant, January 2007 – December 2018
Grants (Completed):
“Paramyxovirus F protein-promoted membrane fusion”
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R56, August 2014 – December 2014
“Paramyxovirus F protein-promoted membrane fusion”
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R01, February 2009 – August 2014
“Transmembrane domain interactions in pathogenic viruses”
Principal Investigator: Rebecca Ellis Dutch
Agency: Southeast Regional Center for Excellence for Emerging Infections and Biodefense/NIAID
Type: Developmental Projects Grant, March 2011 – February 2014
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Rebecca Ellis Dutch
Grants (Completed):
“Paramyxovirus F protein-promoted membrane fusion” supplement
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: Supplemental award to promote diversity/Hackett, July 2012-June 2013
“Paramyxovirus F protein-promoted membrane fusion” supplement
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: Supplemental ARRA award to promote diversity/Hackett, Sept. 2010 – Feb. 2012
“Cathepsin L processing of the Henipavirus F proteins”
Principal Investigator: Rebecca Ellis Dutch
Agency: Southeast Regional Center for Excellence for Emerging Infections and Biodefense
Type: Developmental Projects Grant, March 2009 – February 2011
“Paramyxovirus F protein-promoted membrane fusion” supplement
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: Supplemental ARRA award for summer students, June 2009 – October 2010
“HMPV Fusion protein-host cell interactions”
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R21, August 2007- July 2010
“Proteolytic cleavage of the Hendra virus fusion protein”
Principal Investigator: Rebecca Ellis Dutch
Agency: NIH
Type: R21, March 2005 – March 2008
“Membrane fusion promoted by the human metapneumovirus fusion protein”
Principal Investigator: Rebecca Ellis Dutch
Agency: March of Dimes
Type: Research grant, June 2005 – June 2008
“SV5 and Hendra virus F protein promoted membrane fusion”
Principal Investigator: Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: R01, May 2002 – April 2008
“Mechanism of membrane fusion promoted by the SV5 fusion protein”
Principal Investigator: Rebecca Ellis Dutch
Agency: American Heart Association Ohio Valley Affiliate
Type: Beginning Grant-in-Aid, July 2001 – July 2003
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Rebecca Ellis Dutch
Student Fellowship Grants (Pending):
“Elucidating binding, fusion, and entry of HMPV in cell culture and host tissues”
Edita Klimyte; mentor: Rebecca Dutch
Agency: National Institutes of Health
Type: F30 MD/PhD Predoctoral fellowship, impact score 14.
Student Fellowship Grants (Completed):
“Role of Endocytosis and Intracellular Trafficking on Human Metapneumovirus Fusion and Entry”
Andres Chang, mentor: Rebecca Dutch
Agency: Great Lakes Affiliate, American Heart Association
Type: Predoctoral Fellowship, July 2010 – June 2012
“Host cell surface components required for fusion protein binding and fusion”
Rachel Schowalter, mentor: Rebecca Dutch
Agency: Great Lakes Affiliate, American Heart Association
Type: Predoctoral Fellowship, July 2007 – June 2009
“Expression and Cleavage of the Hendra Virus F protein”
Willie W. Craft and Rebecca Ellis Dutch
Agency: National Institutes of Health, NIAID
Type: Ruth L. Kirschstein National Research Service Award, July 2004 – June 2007
“Mutational Analyses of conserved regions of paramxyovirus fusion proteins”
Amanda Knoebber Gardner, mentor: Rebecca Dutch
Agency: Ohio Valley Affiliate, American Heart Association
Type: Predoctoral Fellowship, July 2004 – June 2006
“Proteolytic cleavage of the Hendra virus fusion protein”
Cara Theresia Pager, mentor: Rebecca Dutch
Agency: Ohio Valley Affiliate, American Heart Association
Type: Predoctoral Fellowship, July 2004 – June 2006
University of Kentucky Beckman Scholar Award
Megan Culler, Undergraduate Researcher
Rebecca Ellis Dutch, Research Mentor
2006-2007
Editorial Responsibilities
PloS Pathogens, Editor for Pearls section, August 2014 – present
Editorial Board, Journal of Biological Chemistry, July 1, 2012 – Sept. 30, 2017
Editorial Board, Journal of Virology, January 1, 2007 – Dec. 31, 2015 (third three year term)
Editorial Board, Virology, September 1, 2013 – August 31, 2016
Guest Editor, special edition of Viruses on Virus-Induced Membrane Fusion, 2013
Ad hoc reviewer for: Journal of Biological Chemistry, Virology, EMBO J., PNAS, Journal of Virology,
Journal of Virological Methods, Journal of Cell Biology, Journal of General Virology, Journal of
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Rebecca Ellis Dutch
Infectious Diseases, Open Journal of Virology, Nature Nanotechnology, Plos Pathogens, BBA –
Biomembranes, Science Translational Medicine, Structure
Grant Review Panels
National Institutes of Health
Ad Hoc member, NIH ZRG1 SSS-F 03 Special Emphasis Panel: Inflammation, Infection and the
Immune Response, April 2004
Member, NIH ZAI PA-1(S1) Special Emphasis Panel: Cooperative Centers for Translational Research
on Human Immunology and Biodefense, May 2004
Ad Hoc Member, NIH ZRG1 IDM-G (90) Special Emphasis Panel: Innovative Research Topics in
Virology, October 2004
Ad Hoc Member, NIH ZRG1 IDM-G 02: Viral Transport, Entry, and Immune Responses,
October 2004
Ad Hoc Member, NIH VIRA: Virology A, June 2005, February 2006
Ad Hoc Member, NIH VIRB: Virology B, June 2006, February 2009. October 2013
Ad Hoc Member, NIH IDM-K, October 2007, March 2008, June 2008
Ad Hoc Member, Special Emphasis Panel: Cooperative Research Partnerships for Biodefense and
Emerging Infectious Diseases, October 2008
Reviewer, ARRA Challenge grants, June 2009
Standing member, NIH VIRB study section, 2009 – 2013
Ad Hoc Member, NIH ZAI1-BDP-I-M1, February 2014
Other grant review responsibilities
Chair, Immunology and Microbiology Study Group, American Heart Association Region I, 2008 - 2009
Co-Chair, Peer Review 4A, American Heart Association Ohio Valley 2007-2008
American Heart Association Ohio Valley 2003-2006 Peer Review Committee
Ad Hoc Reviewer: National Science Foundation, University of Kentucky Research Support Grants,
Kentucky Tobacco Research and Development Center
Invited Presentations
New insights into viral and cellular biology from emerging paramyxoviruses
University of Albany, Department of Biology
Albany, NY, November 7, 2014
Human metapneumovirus entry and assembly
Nebraska Center for Virology Symposium
Lincoln, NE, October 10, 2014
The complexities of paramyxovirus entry
Plenary symposium speaker, FASEB Virus Structure and Assembly meeting
Saxtons River, VT, June 30, 2014
Human metapneumovirus entry and assembly
University of Kansas Medical Center, Department of Microbiology, Molecular Genetics and
Immunology
Kansas City, KS, April 10, 2014
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Rebecca Ellis Dutch
Invited Presentations (con.)
Human metapneumovirus assembly and transmission
Plenary Symposium speaker, Keystone “Ins and Outs of Viral infection” meeting
Breckinridge, CO, April 2, 2014
Human metapneumovirus entry and assembly
Indiana University, Department of Biology
Bloomington, IN, February 11, 2014
Human metapneumovirus entry and assembly
St. Jude Children’s Research Hospital, Center for Infectious Diseases
Memphis, TN, February 3, 2014
Paramyxovirus Entry and Assembly
University of North Carolina Virology Colloquium
Chapel Hill, NC, October 1, 2013
Human Metapneumovirus Entry
Plenary Symposium speaker, American Society for Virology 2013
University Park, PA, July 22, 2013
Lessons from a recently discovered virus: Analysis of human metapneumovirus entry
Distinguished Speaker, Microbiology and Infectious Diseases program
University of Florida, Gainesville, FL, Dec. 3, 2012
Studies of the recently identified human pathogen human metapneumovirus reveal
novel aspects of viral entry
Department of Microbiology, University of Missouri, Jan. 19, 2012
Studies of the recently identified human pathogen human metapneumovirus reveal
novel aspects of viral entry
Department of Pediatrics and Microbiology and Immunology, Vanderbilt University, Dec. 8, 2011
Endocytic trafficking and emerging paramyxoviruses
Student organized international symposium of the DFG Research Training Group 1216 on Intra- and
Intercellular Transport and Communication; Marburg, Germany, Sept. 22, 2011
Increasing diversity of viral entry mechanisms: Studies of emerging paramyxoviruses
State of the Art invited speaker
American Society for Virology meeting, Minneapolis, MN, July 17, 2011
Emerging paramyxoviruses: New insights into viral and cellular virology
Invited Keynote Speaker, Annual Retreat of the Dept. of Molecular Biosciences, Northwestern
University; May 17, 2011
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Rebecca Ellis Dutch
Invited Presentations (con.)
Fusion, folding and trafficking: New insights into the role of membrane-interacting regions in
paramyxovirus fusion proteins
Department of Microbiology and Molecular Genetics, Emory University, March 14, 2011
Studies of the human metapneumovirus fusion protein
MedImmune, October 22, 2010
Fusion, folding and trafficking: New insights into the role of membrane-interacting regions in
paramyxovirus fusion proteins
Department of Microbiology and Immunology, Loyola University School of Medicine, Sept. 16, 2010
Cathepsin L processing of Henipavirus fusion proteins
National RCE meeting; Las Vegas, NV, April 12, 2010
Paramyxovirus Fusion Protein Transmembrane Domain Interactions
Keystone meeting on Cell Biology of Virus Entry, Replication and Pathogenesis; Taos, NM, Feb. 2010
Surprising roles for the endocytic pathway in the life cycle of recently identified paramyxoviruses
Department of Microbiology and Immunology, University of Rochester Medical Center; Jan. 25, 2010
Unexpected roles for the endocytic pathway in the life cycle of recently identified paramyxoviruses
Department of Molecular Microbiology & Immunology
Johns Hopkins Bloomberg School of Public Health, Sept. 17, 2009
Surprising role for the endocytic pathway in the life cycle of recently identified paramyxoviruses
Department of Microbiology and Center for Predictive Medicine For Biodefense and Emerging
Infectious Disease, University of Louisville, August 20, 2009
Novel roles for the endocytic pathway in the life cycle of recently identified paramyxoviruses
Department of Microbiology, University of Iowa, March 10, 2009
Novel characteristics in viral entry of recently identified paramyxoviruses
Plenary talk, FASEB meeting on Virus Structure and Assembly
Saxtons River, Vermont, June 2008
Novel triggering of the fusion protein from the recently identify human metapnemovirus
Plenary talk, Southeastern Regional Virology Conference
Atlanta, GA, April 2008
Novel Characteristics of the HMPV Fusion Protein: cell-cell binding function and triggering of
membrane fusion by low pH
2007 Negative Strand Virus Meeting
Evanston, IL, Sept. 2007
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Rebecca Ellis Dutch
Invited Presentations (con.)
Novel findings for emerging paramyxoviruses: Roles for low pH
Dept. of Microbiology and Immunology, Cornell University, Sept. 7, 2007
Managing Content in Your Talks: Finding the Right Balance
Education and Career Development Workshop
American Society for Virology meeting, July 17, 2007
Endosomal Proteases and Emerging Paramyxoviruses: A New Paradigm for Activation of Viral Fusion
Proteins
Dept. of Microbiology and Immunology, Miami University of Ohio, Nov. 16, 2005
Novel proteolytic processing of the Hendra and Nipah virus fusion proteins
Dept. of Microbiology and Immunology, Uniformed Services University, Sept. 19, 2005
Analysis of Hendra virus glycoproteins: novel aspects of the fusion protein from a newly emerged
paramyxovirus
Dept. of Molecular Biology, The UMDNJ School of Osteopathic Medicine, March 22, 2005
Analysis of Hendra virus glycoproteins: novel aspects of the fusion protein from a newly emerged
paramyxovirus
Dept. of Biochemistry and Molecular Biology, University of Miami School of Medicine, Feb. 18, 2005
Novel aspects of the fusion protein from a newly emerged paramyxovirus
Dept. of Plant Pathology, University of Kentucky, Feb. 7, 2005
Analysis of Hendra virus glycoproteins: novel aspects of the fusion protein from a newly emerged
paramyxovirus
Dept. of Molecular and Cell Biology, University of Connecticut, Oct. 14, 2004
Membrane fusion promoted by paramyxovirus fusion proteins
Department of Physiology, University of Kentucky, May 15, 2002
Membrane fusion promoted by paramyxoviruses
Gluck Center, University of Kentucky, Sept. 16, 2002
Convenor Invitations
Plenary Symposium Convenor, “Mission Impassable: Virus Transit Between Cells”
2013 American Society for Virology meeting, State College, PA
Workshop Convenor, “Virus Receptors and Entry II”
2013 American Society for Virology meeting, State College, PA
Discussion Leader, Virus Entry
2013 Gordon Conference on Viruses and Cells, Il Ciocco, Italy
Workshop Convenor, “Virus Receptors and Entry II”
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Rebecca Ellis Dutch
2009 American Society for Virology meeting, Vancouver, BC, Canada
Session Convenor, “Virus-Host Interactions II”
2008 FASEB Virus Structure and Assembly meeting, Saxtons River, VT
Workshop Convenor, “Paramyxoviruses I: Attachment and Fusion”
2006 American Society for Virology meeting, Madison, WI
Workshop Convenor, “Paramyxoviruses and Bornaviruses”
2005 American Society for Virology meeting, State College, PA
Workshop Convenor, “Paramyxoviruses II”
2003 American Society for Virology meeting, Davis, CA
University Teaching Responsibilities
IBS 603 Cell Biology: Fall, 2001 - 2002. Responsible for presentation of five lectures.
IBS 606 Integrated Biomedical Sciences: Spring, 2001 – 2004. Responsible for presentation of two
lectures.
BCH 610 Biochemistry of Lipids and Membranes: Spring 2002 – present. Responsible for four or five
one and one-half hour lecture/discussion periods.
BCH 618/619 Seminar in Biochemistry: Course director, 2002-2003. Attended and critiqued graduate
student seminars, 2000 - present.
BCH 401G Fundamentals of Biochemistry: Spring 2014 – present, Co-Course Director/responsible for 8
lectures. Spring 2010 – 2013. Course director/responsible for 16 lectures. Fall, 2003 – 2009.
Responsible for presentation of eight lectures in 2003, and twelve lecture from 2004 -2007 and fourteen
lectures from 2008- on.
ABT 395 Independent Study in Agricultural Biotechnology. Served as formal research mentor in course
for Derrick Fowler (2001-2002), Kelly Kutzlo (2004), Hannah Ryan (2004), Megan Culler (2006), Katie
Routt (2007), Jordan Stanek (2008 – 2009), Angela Jones (2010), Shelby Malone (2010-2011), Andrea
Eastes (2012-present) and Mackenzie Crite (2013-present).
BIO 395 Independent Study in Biology. Served as a formal research mentor in course for Hannah Ryan
(2004), Felicia Lozano (2006), Sydnee Moore (2009), Tamas Nagy (2013- present) and Anne Dickson
(2012-2013).
CHE 395 Independent Study in Chemistry. Served as a formal research mentor in course for Nazeeha
Jawahir (2008-2009) and Courtney Ford (2011).
MI 710-002 Molecular Virology: Spring 2004, Spring 2006. Responsible for one lecture.
PED 850 NICU/PED 859 AI/PED 878 PICU: Pediatrics/Biochemistry course. Fall 2008 - present.
Responsible for one lecture/one discussion session, repeated three times per semester.
Guest Lecturer in ABT 101 (2003 – 2006) and ABT 201 (2003, 2005).
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Rebecca Ellis Dutch
College of Medicine Committees
University of Kentucky Circle of Power Women’s Leadership Training Program, 2/01 – 9/01
Search Committee, Physiology Chair, 2002-2003
IBS admissions committee, 2003 – 2006
Search Committee, Biochemistry Chair, 2011 – 2012
Dean’s Search Committee, College of Medicine, 2014 University Committees
Program Planning Committee, 21st Annual American Society for Virology meeting held at University of
Kentucky, July 2002
Co-organizer, University of Kentucky Molecular Virology Club, 2003 – 2009
Plant Pathology Departmental Review Committee, 2003-2004
AgBiotech Program Steering Committee, 2005 – 2008
Radiation Safety Committee, 2006-2012
Research IS Departmental Review Committee, 2007
Graduate Council member, elected, 2008 – 2011
Undergraduate Research Oversight Committee, 2011 – present
University Honors Program Faculty of Record, 2011- present
Strategic Plan Working Group, 2013 – 2014
Co-Chair, Search Committee, University of Kentucky Honors Program Director
National Committees
External Advisory Board, University of Florida T32 in Virology, 2014-2019
Animal Viruses Councilor, American Society for Virology, 2012 – 2015
Chairman, American Society for Virology Education Committee, 2009 – 2012
Chair, 2012 FASEB Virus Assembly meeting
American Society of Virology Education Committee, 2007-2009
American Society of Virology Travel Award Committee, 2007-2009
Unified Steering Committee, American Heart Association, 2009 – 2014
Departmental Committees
Faculty Search Committees, 2008- present
Chair, Faculty Search committee, 2014
Graduate Committees:
Ph.D. Advisor
Willie Craft, 2001 – 2006
Michael Sheehan, 2001 – 2002 (deceased)
Amanda Knoebber Gardner, 2002 - 2007
Cara Pager, 2002-2006
James Carter, 2002 - 2007
Mark Wurth (joint MD/Ph.D. advisor), 2003 - 2006
Shannon Whitman, 2003 - 2008
Rachel Schowalter, 2004 - 2008
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Rebecca Ellis Dutch
Kathleen Gibson, 2005 – 2008
Andreea Popa, 2006 – 2011
Everett Clint Smith, 2007 – 2011
Andres Chang, 2008 – 2012
Brent Hackett, 2009 - 2013
Levi Lampe, 2010 – 2011
Farah El Najjar, 2011 – present
Stacy Webb, 2012 – present
Edita Klimyte, 2012 - present
Thesis Committee Member
Jia Yao, Molecular and Cellular Biochemistry, 2001-2005
Eun Jeong Lim, Molecular and Cellular Biochemistry, 2001-2006
Garland Crawford, Molecular and Cellular Biochemistry, 2002-2008
Meredith Bostrom, Nutritional Sciences, 2003-2006
Nathan Correll, Molecular and Cellular Biochemistry, 2003-2008
Jennifer Rudolph, Molecular and Cellular Biochemistry, 2003-2008
Jason Ren, Molecular and Cellular Biochemistry, 2003-2008
Sowmya Sampath, Molecular and Cellular Biochemistry, 2003-2008
Deborah Even, Microbiology, Immunology, and Molecular Genetics, 2003-2006
Jozsef Stork, Plant Pathology, 2003-2009
Yuri Klyachkin, Microbiology, Immunology, and Molecular Genetics, 2004-2008
Ravi Subramanian, Microbiology, Immunology, and Molecular Genetics, 2004-2008
Janet Louise Lines, Microbiology, Immunology, and Molecular Genetics, 2004-2009
Christopher Matthew Trimby, Physiology, 2004-2011
Yi Jiang, Plant Pathology, 2005-2009
Shaojing Ye, Molecular and Cellular Biochemistry, 2006-2012
Kathleen Martin, Plant Pathology, 2007-2011
Zhengchen Lu, Veterinary Science, 2007-present
Samantha Hoskins, Microbiology, Immunology, and Molecular Genetics, 2008-2012
Ashish Tiwari, Veterinary Science, 2008-present
Nikki Trinh, Molecular and Cellular Biochemistry, 2008-2009
Robin Webb, Molecular and Cellular Biochemistry, 2008-2013
Ashley Laux, Molecular and Cellular Biochemistry, 2009 – 2010
Yunjie Huang, Molecular and Cellular Biochemistry, 2009 - present
Gavin Anderson, Plant Pathology, 2009 – 2014
Meera Nair, Plant Physiology, 2009 – 2014
Meenakshi Banerjee, Molecular and Cellular Biochemistry, 2011 – present
Jeremi Mullins, Microbiology, Immunology, and Molecular Genetics, 2011-present
Megan Phillips, Molecular and Cellular Biochemistry, 2012 – present
Erik Cook, Molecular and Cellular Biochemistry, 2012 – present
Smita Joshi, Molecular and Cellular Biochemistry, 2012 – present
Hye-In Jang, Molecular and Cellular Biochemistry, 2012 – present
Mike Grossheim, Physiology, 2013 – present
Grant Jones, Microbiology, Immunology, and Molecular Genetics, 2013-present
Michelle Pitts, Microbiology, Immunology, and Molecular Genetics, 2013-present
Joshua Ferrell, Microbiology, Immunology, and Molecular Genetics, 2014-present
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Rebecca Ellis Dutch
Alex Helman, Molecular and Cellular Biochemistry, 2014 – present
External Member, Thesis Defense
Kevin Forbes, Plant Pathology, 2004
Raksha Tiwari, Veterinary Science, 2007
Liang Zhang, Veterinary Science, 2011
Yumei Zheng, Plant and Soil Sciences, 2010
Rania Al Hawas, 2012
Additional Mentoring Activities:
Postdoctoral researchers:
Cyril Masante, 2008 – 2011
Nicolas Cifuentes-Munoz, 2014 - present
Undergraduate researchers:
Kimberly Martin, 2001-2002
Derrick Fowler, 2002-2003
Dava West, 2002-2003
Hannah Ryan, 2003-2004
Kelly Kutzlo Meulendyke, 2004-2005
Jaime Manwani, summer 2004
Megan Culler, 2005 - 2008
Felicia Lozano, 2006 – 2007
Caleb Howard, summer 2007
Katie Routt, 2008
Angela Jones, summer 2008
Alison Ashbrook, summer 2008
Jory Stanek, 2008 - 2010
Nazeeha Jawahir, 2008 – 2010
Shanna Bowersox, summer 2009
Sydnee Moore, 2009 – 2010
Anna Smith, summer 2010
Sydney Crawley, summer 2010
Kelsey Field, 2010 – 2012
Shelby Malone, 2010 – 2011
Courtney Ford, 2010 – 2012
Tim Waits, 2011 – 2012
Tamas Nagy, 2012- present
Ann Dickson, 2012 – 2013
Andrea Eastes, 2013 – present
Bushra Manzar, 2013 – present
Mackenzie Crite, 2013 - present
Faculty Advisor for Student Seminars
Tara Rutledge, 2000
Leroy Pakkiri, 2001
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Rebecca Ellis Dutch
Deborah Sullivan, 2001
Kalil Ray, 2003
Brian York, 2003
Sowmya Swapath, 2004
Richard Singiser, 2005
Sowmya Swapath, 2005
Wansung Choi, 2005
Megan Sampley, 2006
Shaojing Ye, 2007
Jamie Cantrell, 2008
Lance Hellman, 2008
Deepa Jonnalagadda, 2010
Thomas Platt, 2012
Rotation Advisor
James Carter, 2000
Willie Craft, Jr., 2000
Michael S. Sheehan, 2001
Rexford Asare, 2001
Amanda Knoebber, 2001
Qingbei Zhang, 2001
Cara Pager, 2002
Shannon Whitman, 2002
Jennifer Rudolph, 2002
Erin Rutherford, 2002
Nathan Correll, 2003
Erin James, 2003
Rachel Schowalter, 2003
Yuri Klyachkin, 2004
Jennifer Marcum, 2004
Kathleen Gibson, 2004
Zhan Ye, 2005
Mosoka Fallah, 2005
Peter Kpere-Daibo, 2005
Lilia Turcios, 2005
Luke Searcy, 2005
Daniel O’Quinn, 2006
Andreea Popa, 2006
Andres Chang, 2006
Everett Clint Smith, 2006
Ryan Readnower, 2006
Kathleen Schoch, 2007
Brent Hackett, 2009
Cetawayo Rashid, 2009
Jenny Lutshumba, 2009
Ishita Parikh, 2009
Kara Larson, 2009
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Rebecca Ellis Dutch
Morgan Freeman, 2009
Levi Lampe, 2010
Rotation Advisor (con.)
Jeremi Mullins, 2010
Farah El Najjar, 2010
Satrio Husodo, 2010
Stacy Webb, 2011
Mike Grossheim, 2011
Angie Drake, 2011
Smita Joshi, 2012
Hye In Jang, 2012
Marcus Niemann, 2012
Grant Jones, 2012
Michelle Harmon, 2013
Justin Surface, 2013
Alexandra Gjevre, 2013
Kris Schroder, 2013
Joshua Ferrell, 2013
Han Ly, 2014
Hilaree Frazier, 2014
Oral Presentations of Research from Dutch laboratory:
Role of the cytoskeleton in the assembly and transmission of human metapneumovirus
Farah El Najjar and Rebecca E. Dutch
XVIth International Congress of Virology
Montreal, Canada, July 2014
Role of fusion protein TM-TM interactions in protein stability and viral fusion
Stacy Webb, Andreea Popa, Stacy Smith and Rebecca Ellis Dutch
Bluegrass Biophysics Symposium
Lexington, KY, May 2014
Role of the cytoskeleton in the assembly and transmission of human metapneumovirus
Farah El Najjar and Rebecca E. Dutch
Thirteenth Southeastern Regional Virology Conference
Atlanta, GA, April 2014
The role of fusion protein TM-TM interactions in viral fusion
Stacy Webb, Andreea Popa, Stacy Smith and Rebecca Ellis Dutch
Thirteenth Southeastern Regional Virology Conference
Atlanta, GA, April 2014
The HMPV SH protein has properties of a viroporin and can serve as a regulator of viral fusogenic
activity
Andres Chang, Cyril Masante, Farah El Najjar, Angela Jones, and Rebecca Ellis Dutch
Thirteenth Southeastern Regional Virology Conference
Atlanta, GA, April 2014
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Rebecca Ellis Dutch
Oral Presentations of Research from Dutch laboratory (con.):
The role of fusion protein TM-TM interactions in viral fusion
Stacy Webb, Andreea Popa, Stacy Smith and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA, July 2013
Analysis of cathepsin and furin proteolytic processing of viral fusion proteins in cells of the bat reservoir
host
Farah El Najjar and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA, July 2013
Proteolytic processing of Hendra virus fusion protein in cells of the bat reservoir host
Farah El Najjar and Rebecca Ellis Dutch
Twelth Southeastern Regional Virology Conference
Atlanta, GA, March 2012
Potential electrostatic interactions in multiple regions affect HMPV F-mediated membrane fusion
Brent A. Hackett, Andres Chang and Rebecca Ellis Dutch
Twelth Southeastern Regional Virology Conference
Atlanta, GA, March 2012
HMPV binding and entry requires a cascade of cellular interactions
Andres Chang, Cyril Masante, Ursula J. Buchholz and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Minneapolis, MN, July 2011
Analysis of the human metapneumovirus SH protein
Cyril Masante, Angela Jones, Farah El Najjar, Carole L. Moncman and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Minneapolis, MN, July 2011
Role of electrostatic interactions in the fusion activity of the HMPV F protein
Brent A. Hackett, Andres Chang and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Minneapolis, MN, July 2011
The role of the Hendra virus F transmembrane domain in endocytic trafficking
Andreea Popa, James Carter, Stacy Smith and Rebecca Ellis Dutch
Short Talk selected from abstracts, FASEB Virus Assembly meeting
Saxtons River, VT, June 2010
The HMPV F protein H435 region is an important but not sole regulator of fusion triggering
Andres Chang, Rachel M. Schowalter, Ursula J. Buchholz, and Rebecca Ellis Dutch
Talk selected from the abstracts, XIV International Conference on Negative Strand Viruses
Bruges, Belgium, June 2010
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Rebecca Ellis Dutch
Oral Presentations of Research from Dutch laboratory (con.):
Sequence and structural dependency of the Hendra F fusion peptide
Everett C. Smith and Rebecca Ellis Dutch
Eleventh Southeastern Regional Virology Conference
Atlanta, GA, March 2010
The role of the Hendra virus F transmembrane domain in endocytic trafficking
Andreea Popa, James Carter, Stacy Smith and Rebecca Ellis Dutch
Eleventh Southeastern Regional Virology Conference
Atlanta, GA, March 2010
Properties of the cellular and viral partners for human metapneumovirus-cell interaction
Cyril Masante and Rebecca Ellis Dutch
Eleventh Southeastern Regional Virology Conference
Atlanta, GA, March 2010
Paramyxovirus fusion protein transmembrane domain interactions: potential roles in protein folding
Stacy E. Smith, Lance M. Hellman, James Carter, Michael G. Fried and Rebecca Ellis Dutch
Eleventh Southeastern Regional Virology Conference
Atlanta, GA, March 2010
Role of endocytosis in human metapneumovirus entry
Andres Chang, Rachel Schowalter, and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Vancouver, BC, July 2009
The role of Hendra virus F transmembrane domain in endocytic trafficking
Andreea Popa, James R. Carter, Stacy E. Smith and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Vancouver, BC, July 2009
Examination of the role of histidine residues proximal to the cleavage site on cathepsin L processing of
the Hendra virus fusion protein
Everett C. Smith, Rachel M. Schowalter and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Vancouver, BC, July 2009
Analysis of transmembrane domain interactions in paramyxovirus fusion proteins using sedimentation
equilibrium analytical ultracentrifugation
Stacy E. Smith, Lance M. Hellman, Michael G. Fried, and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Vancouver, BC, July 2009
Study of Hendra virus fusion protein using short polypeptide tags
Andreea Popa, Cara T. Pager, and Rebecca Ellis Dutch
Tenth Southeastern Regional Virology Conference, workshop presentation
Atlanta, GA, April 2008
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Rebecca Ellis Dutch
Oral Presentations of Research from Dutch laboratory (con.):
HMPV F protein-mediated membrane fusion can be triggered by low pH
Rebecca Ellis Dutch, Stacy E. Smith and Rachel M. Schowalter
American Society for Virology meeting, workshop presentation
Corvallis, OR, July 2007
Mutational analysis of the Hendra virus fusion protein transmembrane domain
James Richard Carter, Mark Allen Wurth and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Madison, WI, July 2006
Characterization of the cytoplasmic domain of the Hendra virus fusion protein
Kathleen M. Gibson, Hector C. Aguilar, Benhur Lee, and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
Madison, WI, July 2006
A role for actin dynamics in paramyxovirus F mediated fusion
Mark A. Wurth, Rachel M. Schowalter, Carole L. Moncman, Rebecca Ellis Dutch and Richard O.
McCann
Ninth Southeastern Regional Virology Conference, workshop presentation
Atlanta, GA, March 2006
A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by
cathepsin L
Rebecca Ellis Dutch, Cara T. Pager, Willie W. Craft, Jr. and Jared Patch
Ninth Southeastern Regional Virology Conference, workshop presentation
Atlanta, GA, March 2006
Sequence requirements for the proteolytic processing of the Hendra virus fusion protein
Willie W. Craft, Jr., and Rebecca Ellis Dutch
Ninth Southeastern Regional Virology Conference, workshop presentation
Atlanta, GA, March 2006
A C-terminal tyrosine plays an important role in Hendra virus F protein transport and membrane fusion
Kelly Kutzlo Meulendyke, Mark Allen Wurth, Richard O. McCann and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA June 2005
Rho-GTPases play a role in paramyxovirus F protein-induced membrane fusion
Rachel M. Schowalter, Mark Allen Wurth, Richard O. McCann, Carole L. Moncman and
Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA June 2005
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Rebecca Ellis Dutch
Oral Presentations of Research from Dutch laboratory (con.):
A role for actin dynamics in paramyxovirus F mediated fusion
Mark Allen Wurth, Rachel M. Schowalter, Carole L. Moncman, Richard O. McCann and
Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA June 2005
The Hendra virus fusion protein is proteolytically processed by a cathepsin-like protease
Rebecca Ellis Dutch and Cara Theresia Pager
American Society for Virology meeting, workshop presentation
State College, PA June 2005
Defining a role for a conserved regions of the F2 subunit in paramyxovirus fusion proteins
Amanda Elizabeth Gardner and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation
State College, PA June 2005
Hendra virus glycoprotein G plays a concentration dependent role on the promotion of Hendra F proteinmediated fusion
Shannon Dawn Whitman, Cara Theresia Pager and Rebecca Ellis Dutch
American Society for Virology meeting, workshop presentation,
State College, PA June 2005
Rho-GTPases play a role in paramyxovirus F protein-induced membrane fusion
Rachel M. Schowalter, Mark Allen Wurth, Richard O. McCann, Carole L. Moncman and
Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology, Workshop presentation
San Diego, April 2005
Role of the actin cytoskeleton in paramyxovirus F protein-mediated membrane fusion
Mark Allen Wurth, Rachel M. Schowalter, Rebecca Ellis Dutch and Richard O. McCann
Signal Transduction in Viral Systems
Savannah, December 2004
Non-convertase processing of the Hendra virus fusion protein
Cara Theresia Pager, Willie Warren Craft, Mark Allen Wurth and Rebecca Ellis Dutch
Gordon Conference on Proprotein processing, trafficking and secretion
New London, NH, July 2004
Proteolytic processing and surface expression of the Hendra virus fusion protein
Willie Warren Craft and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology, Workshop presentation
Boston, MA, June 2004
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Rebecca Ellis Dutch
Oral Presentations of Research from Dutch laboratory (con.):
Analysis of the proteolytic cleavage of the Hendra virus fusion protein
Willie Warren Craft and Rebecca Ellis Dutch
American Society for Virology meeting, Workshop presentation
Davis, CA, July 2003
Proteolytic cleavage of the Hendra virus fusion protein
Cara Theresia Pager, Mark Allen Wurth and Rebecca Ellis Dutch
American Society for Virology meeting, Workshop presentation
Davis, CA, July 2003
N-linked glycosylation of the Hendra virus fusion protein
James Carter, Stephen Derrick Fowler, Dava Susanne West and Rebecca Ellis Dutch
American Society for Virology meeting, Workshop presentation
Davis, CA, July 2003
Mutational analysis of a conserved region in paramxyovirus fusion proteins
Amanda Elizabeth Knoebber, Kimberly Louise Martin and Rebecca Ellis Dutch
American Society for Virology meeting, Workshop presentation
Davis, CA, July 2003
Mutational analysis of a conserved region in paramxyovirus fusion proteins
Amanda Elizabeth Knoebber, Kimberly Louise Martin and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology, Workshop presentation
San Diego, April 2003
Poster Presentations of Research from Dutch laboratory:
Stacy R. Webb and Rebecca Ellis Dutch
Fusion protein TM-TM interactions: modulators of pre-fusion stability and potential regulators of
membrane fusion
FASEB Virus Structure and Assembly meeting
Saxtons River, VT, July 2014
Edita Klimyte, Andres Chang and Rebecca Ellis Dutch
Variability in fusogenic activity of human metapneumovirus fusion protein from different strains
American Society for Virology meeting
State College, July 2013
Analysis of proteolytic enzymes involved in fusion protein activation in Pteropus bats: implications for
emerging viruses
Farah El Najjar, Michele Baker, Lin-Fa Wang, and Rebecca Ellis Dutch
Gordon Conference on Viruses and Cells
Il Ciocco, Italy, May 2013
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Rebecca Ellis Dutch
Poster Presentations of Research from Dutch laboratory (con.)
Proteolytic processing of Hendra virus fusion protein in cells of the bat reservoir host
Farah El Najjar and Rebecca Ellis Dutch
FASEB Virus Assembly meeting
Saxtons River, VT, June 2012
:Potential electrostatic interactions in multiple regions affect HMPV F-mediated membrane fusion
Brent A. Hackett, Andres Chang and Rebecca Ellis Dutch
FASEB Virus Assembly meeting
Saxtons River, VT, June 2012
Transmembrane domain interactions in fusion proteins from pathogenic viruses
Stacy R. Webb, Stacy E. Smith, Everett Clinton Smith, Manana Melikishvili, Michael G. Fried and
Rebecca Ellis Dutch
FASEB Virus Assembly meeting
Saxtons River, VT, June 2012
Analysis of paramyxovirus fusion protein proteolytic activation in cells from the bat reservoir host
Farah El Najjar, Levi M. Lampe and Rebecca Ellis Dutch
American Society for Virology meeting
Minneapolis, MN, July 2011
Analysis of paramyxovirus fusion protein proteolytic activation in cells from the bat reservoir host
Levi M. Lampe and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology meeting
Washington, DC, April 2011
The role of the Hendra virus F transmembrane domain in endocytic trafficking
Andreea Popa, James Carter, Stacy Smith and Rebecca Ellis Dutch
FASEB Virus Assembly meeting
Saxtons River, VT, June 2010
Sequence and structural dependency of the Hendra F fusion peptide
Everett C. Smith and Rebecca Ellis Dutch
XIV International Conference on Negative Strand Viruses
Bruges, Belgium, June 2010
Examination of the Hendra F fusion peptide: Sequence and structural dependency of membrane fusion
Rebecca Ellis Dutch and Everett C. Smith
FASEB Virus Assembly meeting
Saxtons River, VT, June 2010
Modulation of membrane fusion by the human metapneumovirus SH protein
Cyril Masante, Angela Jones, and Rebecca Ellis Dutch
FASEB Virus Assembly meeting
Saxtons River, VT, June 2010
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Rebecca Ellis Dutch
Poster Presentations of Research from Dutch laboratory (con.):
Modification of the pH dependent function of the HMPV F protein
Brent Hackett and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology meeting
Anaheim, CA, April 2010
Role of endocytosis in HMPV entry
Andres Chang, Rachel Schowalter, and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology meeting
New Orleans, LA April 2009
Examination of the role of histidine residues proximal to the cleavage site on cathepsin L processing of
the Hendra virus fusion protein
Everett Clinton Smith, Rachel M. Schowalter and Rebecca Ellis Dutch
FASEB meeting on Virus Structure and Assembly, Saxtons River, VT, June 2008
Addition of short polypeptide tags to Hendra virus fusion protein modulates membrane fusion
Andreea Popa, Cara T. Pager and Rebecca Ellis Dutch
FASEB meeting on Virus Structure and Assembly
Saxtons River, VT, June 2008
Additions at the cytoplasmic tail of the Hendra virus fusion protein modulate membrane fusion
Andreea Popa, Cara T. Pager and Rebecca Ellis Dutch
American Society for Virology meeting
Corvallis, OR, July 2007
Tyrosine residues within the cytoplasmic tail of the Hendra fusion glycoprotein play an important role in
trafficking and processing
Kathleen M. Gibson, Mark A. Wurth, Kelly A. Meulendyke, Hector Aguilar, Benhur Lee and Rebecca
Ellis Dutch
American Society for Virology meeting
Corvallis, OR, July 2007
Membrane fusion promoted by the human metapneumovirus fusion protein
Rachel M. Schowalter, Stacy Smith and Rebecca Ellis Dutch
Gordon Conference on Viruses and Cells
Tilton, New Hampshire, June 2007
Additions at the cytoplasmic tail of the Hendra virus fusion protein modulate membrane fusion
Andreea Popa, Cara T. Pager and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
Washington, D.C., April 2007
Defining the roles for conserved regions in paramyxovirus fusion proteins
Rebecca Ellis Dutch and Amanda Elizabeth Gardner
FASEB meeting on Virus Assembly
Saxtons River, VT, June 2006
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Rebecca Ellis Dutch
Poster Presentations of Research from Dutch laboratory (con.):
Processing of the Nipah virus fusion protein by cathepsin L produces a mature and fusogenic protein
Cara T. Pager, Willie W. Craft, Jr., Jared Patch and Rebecca Ellis Dutch
FASEB meeting on Virus Assembly
Saxtons River, VT, June 2006
Characterization of HMPV F protein-promoted membrane fusion
Rachel M. Schowalter, Stacy Smith and Rebecca Ellis Dutch
FASEB meeting on Virus Assembly
Saxtons River, VT, June 2006
Increased requirement for Hendra glycoprotein G in Hendra F-mediated fusion is due to its increased
rate of degradation
Shannon D. Whitman and Rebecca Ellis Dutch
XIII International Conference on Negative Strand Viruses
Salamanca, Spain, June 2006
Defining the roles for conserved regions in paramyxovirus fusion proteins
Amanda E. Gardner and Rebecca Ellis Dutch
XIII International Conference on Negative Strand Viruses
Salamanca, Spain, June 2006
Analysis of the Cytoplasmic Tail Domain of the Hendra Virus Fusion Protein
Kathleen M. Gibson, Mark Allen Wurth, and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
San Francisco, CA, April 2006
A mature and fusogenic form of the Nipah virus fusion protein requires proteolytic processing by
cathepsin L
Cara T. Pager, Willie W. Craft, Jr., Jared Patch, and Rebecca Ellis Dutch
Keystone Symposia on Cell Biology of Virus Entry, Replication and Pathogenesis
Santa Fe, NM, February 2006
The Hendra virus fusion protein is proteolytically processed by a cathepsin-like protease
Cara Theresia Pager and Rebecca Ellis Dutch
Gordon Conference on Viruses and Cells
Il Ciocco, Italy, May 2005
Role of the cytoplasmic domain of the Hendra virus fusion protein in the promotion of membrane fusion
Mark Allen Wurth, Kelly Kutzlo, Richard O. McCann and Rebecca Ellis Dutch
American Society of Virology meeting
Montreal, Canada, July 2004
N-linked glycosylation of the Hendra virus fusion protein
James Carter, Stephen Derrick Fowler, Cara Theresia Pager, Dava S. West and Rebecca Ellis Dutch
FASEB meeting on Virus Assembly
Saxton’s River, VT, July 2004
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Rebecca Ellis Dutch
Poster Presentations of Research from Dutch laboratory (con.):
Characterization of the Proteolytic Processing of the Hendra virus fusion protein
Cara Theresia Pager, Willie Warren Craft, Mark Allen Wurth and Rebecca Ellis Dutch
FASEB meeting on Virus Assembly
Saxton’s River, VT, July 2004
A conserved region in paramyxovirus fusion proteins is required for oligomerization
Amanda Elizabeth Knoebber, Kimberly Louise Martin and Rebecca Ellis Dutch
FASEB meeting on Virus Assembly
Saxton’s River, VT, July 2004
Role of the Hendra G protein in promotion of membrane fusion by Hendra F
Shannon Dawn Whitman, Cara Theresia Pager and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
Boston, MA 2004
Role of the cytoplasmic domain of the Hendra virus fusion protein in the promotion of membrane fusion
Mark Allen Wurth, Kelly Kutzlo, Richard O. McCann and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
Boston, MA 2004
Analysis of the Hendra virus glycoproteins: novel aspects of the fusion protein from a newly emerged
paramyxovirus
Cara Theresia Pager, Willie Warren Craft, James Carter, Mark Allen Wurth, Shannon D. Whitman and
Rebecca Ellis Dutch
Replication and Cell Biology of Negative Strand Viruses
Evanston, IL, June 2004
A conserved region in paramyxovirus fusion proteins is required for oligomerization
Amanda Elizabeth Knoebber, Kimberly Louise Martin and Rebecca Ellis Dutch
Fourth Cell Biology of Viral Entry Meeting
Frederick, MD, May 2004
Characterization of the Proteolytic Processing of the Hendra virus fusion protein
Willie Warren Craft, Cara Theresia Pager, Mark Allen Wurth and Rebecca Ellis Dutch
Fourth Cell Biology of Viral Entry Meeting
Frederick, MD, May 2004
Analysis of the proteolytic cleavage of the Hendra virus fusion protein
Cara Theresia Pager, Willie Warren Craft, Mark Allen Wurth, and Rebecca Ellis Dutch
Gordon Conference on Viruses and Cells
Il Ciocco, Italy, May 2003
Analysis of the proteolytic cleavage of the Hendra virus fusion protein
Willie Warren Craft and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
San Diego, April 2003
- 27 -
Rebecca Ellis Dutch
Poster Presentations of Research from Dutch laboratory (con.):
Proteolytic cleavage of the Hendra virus fusion protein
Cara Theresia Pager, Mark Allen Wurth and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
San Diego, April 2003
Mutational analysis of a conserved region in paramxyovirus fusion proteins
Amanda Elizabeth Knoebber, Kimberly Louise Martin and Rebecca Ellis Dutch
American Society of Biochemistry and Molecular Biology
San Diego, April 2003
Role of N-terminal Heptad Repeat Residues in folding and processing of the SV5 F protein
Rebecca Dutch, Patrick Segeleon and Michael Sheehan
Cell Biology of Viral Entry meeting
Frederick, MD; May 2002
Role of N-terminal Heptad Repeat Residues in folding and processing of the SV5 F protein
Rebecca Dutch, Patrick Segeleon and Michael Sheehan
FASEB meeting on Virus Assembly
Saxtons River, VT; June 2002
The role of N-linked glycosylation of the Hendra virus fusion protein
James Carter, Stephan Derrick Fowler, Rebecca Dutch
American Society for Virology meeting
Lexington, KY; July 2002
Role of N-terminal Heptad Repeat Residues in folding and processing of the SV5 F protein
Rebecca Dutch, Patrick Segeleon and Michael Sheehan
American Society for Virology meeting
Lexington, KY; July 2002
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