“Future of Biomedicine” Industry Day
University of Glasgow
24th Sept 2015
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HISTOINDEX – BRINGING DIAGNOSIS INTO BIOPSY
World’s first fully-automated, 3-D, quantitative, laser-based
imaging system for tissue diagnostic
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GLOBAL TISSUE DIAGNOSTICS MARKET
1
• Fastest growth segment with a compounded annual growth rate
(CAGR) of 12% in the entire in vitro diagnostics (IVD) market
• Global market for tissue diagnostic products in 2012: US$2.4
billion; expected to reach US$6.74 billion by 2020
• 76% of total global demand to originate from US/EU in 2014;
APAC/ROTW to increase to almost 36% by 2020
1
Carson, Jennifer. "Analysis of the Global Tissue Diagnostics Market." Frost & Sullivan, Nov. 2013.
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3 BIG PREDICTIONS
1
1. Convergence of different medical technologies - integrated
diagnostics
2. Pathology will transit toward a collaboration with clinical next
generation sequencing to enable a combination of pathology and
genomic information
3. The evolution of digital pathology, tele-pathology, and virtual
consultation, the outpouring of data from pathology laboratories
will necessitate cloud storage platforms
1
Carson, Jennifer. "Analysis of the Global Tissue Diagnostics Market." Frost & Sullivan, Nov. 2013.
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WHAT ARE CUSTOMERS LOOKING FOR?
SIZE
SPEED
OBJECTIVE
PRICE
SPECIFIC
ACCURACY
QUANTIFICATION
TARGET
CUSTOMER
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WHAT DO WE OFFER?
CLOUD
GENESIS®
LAENNEC™
• When is
• How did
the disease
progress/r
egress?
• Why did
that
happen?
Cloud-based
Integrated
Diagnostics
leading to
Personalized
Treatment
treatment
needed?
• What
treatment
to give?
DISEASE-SPECIFIC DIAGNOSIS
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HOW IT WORKS
cells
LASER
ECM
He et al., Journal of Biomedical Optics, 15(5) 056007, 2010.
Bredfeldt et al., Journal of Pathology Informatics, 5(1), 28, 2014
Raja et al., Journal of Biomedical Optics 15(5) 056016, 2010.
Gailhouste et al., Journal of Hepatology 52, 398-406, 2010.
Asselah et al, Journal of Hepatology 61, 193-195, 2014.
Tai et al., Hepatology 50(4) 1093, 2009.
Tai et al., Journal of Biomedical Optics, 14(4) 044013, 2009.
Xu et al., Journal of Hepatology, 61, 260-269, 2014.
Improvement in accuracy of tissue diagnosis from
65% to more than 95%
Bedossa et al., Hepatology 20, 15-20 (1994); Gronbaek et al., Journal of Viral Hepatitis 9, 443449 (2002); Theodossi et al., Gastroenterology 79, 232-241 (1980); Theodossi et al., Gut 35, 961968 (1994); Westin et al., Liver 19, 183-187 (1999)
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REVOLUTIONARY TECHNOLOGY
Current Method
Stage 1
Stage 2
Stage 3
Stage 4
Stage 3.1
Stage 4.7
HistoIndex Stain-Free
Stage 1.2
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Stage 2.5
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KEY BENEFITS
Sample
Staining
Imaging
Staging
Diagnosis
1 – 3 days
Sample
HistoIndex
Stain-free Technology
Diagnosis
0.5 – 1 hr
 Patients (Hospitals and Clinics):
Same day results – greater accuracy & efficiency
 Users (Researchers, Drug companies & CROs):
Better specificity & sensitivity
A "translational" program to measure drug efficacy from the
beginning of preclinical studies to the end of the clinical trial
 Insurance/Enterprises:
Early detection and prediction, due to backend database
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WE HAVE MADE THIS ROBUST AND SIMPLE
From this…..
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WE HAVE MADE THIS ROBUST AND SIMPLE
To THIS…..
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WHAT IS THIS NEW STANDARD?
Hardware Genesis®200
Software FibroIndex™ +
LiverCloud™
Multi-photon
microscope
utilizing a high power laser
Quantification
support database
Customized optics
Cloud-based database & online
assessment
for
decision
Computer-assisted
tissue diagnostic
system
Fully automated
One-touch operation
Unstained tissues
Multi-organ capabilities
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3D visualization
HISTOINDEX
is setting a
NEW STANDARD!
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GLOBAL PRESENCE
Physical units placement
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Clinical/Research sites with samples sending to HistoIndex’s global
Imaging Service Centres
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PRODUCTS
Liver
Kidney
Genesis®100
Skin
Genesis®200
Lung
…20+ Organs
LiverCloud™
Laennec™
Launched
in Jun 2015
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Single Organ
Multiple Organs
Online Assessment
Production
ceased
(2012)
Research
use only
(2013)
Database
dev’mnt
Clinical Diagnosis
Selling for
Regulatory
research
in progress
use
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CUSTOMERS, CLIENTS & 4 OTHER Cs
Clinical Research:
Clinical Application:
Tool is most flexible and useful; no regulatory
approval needed
Cloud services, gold standard for liver
fibrosis diagnosis
Consumables: Glass slide, optical fiber
Consumers: Skin diagnostics, household products
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SUMMARY
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1.
Maximum impact & profit margin through HistoIndex existing global Imaging
Service Centres in US, EU & Asia
2.
Clinical Research drives Clinical Application
3.
Clinical Application drives Clinical Integrative Diagnostics Platform
4.
We have an unique product & business model
5.
This is NOT only a liver story
6.
Liver, Kidney, Lungs, Heart, Cancers, Skin, Cosmetics
7.
Changing the way diagnostics are performed and  Treatments developed
 Creating a new gold standard
8.
10 Years from now, everyone will be touched by HistoIndex
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HISTOINDEX PTE LTD
Contact:
GIDEON HO Ph.D., M.Eng.
Chief Executive Officer
Email to: gideon.ho@histoindex.com
Website: http://www.histoindex.com
Services: http://www.genesisimagingservices.com
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