Viterbi training Initialize emission and transition probabilities to random numbers. while (true) Do Viterbi decoding using current parameters Save current parameters as previous parameters. Re-estimate emission and transition parameters from the state path decoded by Viterbi. (add pseduocounts, see next page). if sum of absolute difference between current and previous parameters is tiny (e.g., < 0.00001), break; end print current parameter and P(sequence, viterbi path) Repeat the above procedure several times (with different random seed), and compare P(sequence, viterbi path). Report the parameters learned that give the largest P. Re-estimate parameters with pseudocounts • Count number of transitions, n_xy, where Pseudocount x, y = {a, b} • t_xy = (n_xy+c) / sum_x(n_xy+c) – e.g. t_ab = (n_ab +1) / (n_ab + n_aa + 2) • Count number of symbols in each state, N_aX and N_bX, where X = A, C, G, T • e_aX = (N_aX + 1) / (sum_X N_aX + 4) • e_bX = (N_bX + 1) / (sum_X N_bX + 4) Backward-Forward algorithm: Compute sum of probabilities in log space • Two probabilities x and y, x < y • lx = log(x), ly = log(y), (lx < ly) • z = x + y = y (1 + x/y) lz = log(z) = log(x+y) = log(y) + log(1 + x/y) = ly + log(1 + exp(log(x)-log(y)) = ly + log(1 + exp(lx – ly)) Also see page 4 in this doc: http://cs.utsa.edu/~jruan/teaching/cs5263_fall_2007/proj1.pdf and page 77 of the handouts.