Publications for Kumudika de Silva
Publications for Kumudika de Silva
>[More Information]</a>
2016
Thirunavukkarasu, S., de Silva, K., Begg, D.,
Whittington, R., Plain, K. (2015). Macrophage
polarization in cattle experimentally exposed to
Mycobacterium avium subsp. paratuberculosis.
Pathogens and Disease, 73(9), 1-9. <a
href="http://dx.doi.org/10.1093/femspd/ftv085">
[More Information]</a>
Swift, B., Huxley, J., Plain, K., Begg, D., de
Silva, K., Purdie (Williams), A., Whittington, R.,
Rees, C. (2016). Evaluation of the limitations
and methods
to improve rapid phage-based detection
of viable Mycobacterium avium subsp.
paratuberculosis in the blood of
experimentally infected cattle. BMC Veterinary
Research, 12(115). <a
href="http://dx.doi.org/10.1186/s12917-016-072
8-2">[More Information]</a>
Swift, B., Huxley, J., Plain, K., Begg, D., de
Silva, K., Purdie (Williams), A., Whittington, R.,
Rees, C. (2016). Evaluation of the limitations
and methods to improve rapid phage-based
detection of viable Mycobacterium avium subsp.
paratuberculosis in the blood of
experimentally infected cattle. BMC Veterinary
Research, 12, 115. <a
href="http://dx.doi.org/10.1186/s12917-016-072
8-2">[More Information]</a>
Thirunavukkarasu, S., de Silva, K., Plain, K.,
Whittington, R. (2016). Role of host- and
pathogen-associated lipids in directing the
immune response in mycobacterial infections,
with emphasis on Mycobacterium avium subsp.
paratuberculosis. Critical Reviews in
Microbiology, 42(2), 262-275. <a
href="http://dx.doi.org/10.3109/1040841x.2014.
932327">[More Information]</a>
2015
de Silva, K. (2015). CD4+ T cells, gamma delta
T cells and B cells are associated with
non-responsiveness to vaccination in
Mycobacterium avium subspecies
paratuberculosis infection. Keystone Symposia
on Molecular and Cellular Biology, N/A: N/A.
de Silva, K., Plain, K., Begg, D., Purdie
(Williams), A., Whittington, R. (2015). CD4+
T-cells, T-cells and B-cells are associated with
lack of vaccine protection in Mycobacterium
avium subspecies paratuberculosis infection.
Vaccine, 33, 149-155. <a
href="http://dx.doi.org/10.1016/j.vaccine.2014.1
0.082">[More Information]</a>
Plain, K., Waldron, A., Begg, D., de Silva, K.,
Purdie (Williams), A., Whittington, R. (2015).
Efficient, validated method for the detection of
mycobacterial growth in liquid culture media
using bead-beating, magnetic particle nucleic
acid isolation and quantitative PCR. Journal of
Clinical Microbiology, 53(4), 1121-1128. <a
href="http://dx.doi.org/10.1128/JCM.03521-14"
Begg, D., de Silva, K., Plain, K., Purdie
(Williams), A., Dhand, N., Whittington, R.
(2015). Specific faecal antibody responses in
sheep infected with Mycobacterium avium
subspecies paratuberculosis. Veterinary
Immunology and Immunopathology, 166(3-4),
125-131. <a
href="http://dx.doi.org/10.1016/j.vetimm.2015.0
6.011">[More Information]</a>
Johansen, M., Purdie (Williams), A., de Silva,
K., Plain, K., Begg, D., Whittington, R. (2015).
The role of intracellular cholesterol within
macrophages exposed to Mycabacterium Avium
subsp. paratuberculosis. 43rd Annual Scientific
Meeting of the Australian Society for
Microbiology, N/A: N/A.
2014
Plain, K., Marsh, I., Begg, D., Purdie (Williams),
A., de Silva, K., Whittington, R. (2014). A new
molecular diagnostic test for Johne's disease;
from lab to national uptake. 12th International
Colloquium on Paratuberculosis, Italy: N/A.
Purdie (Williams), A., Begg, D., de Silva, K.,
Plain, K., Whittington, R. (2014). Consistent
gene expression panels identified at early time
points that predict clinical outcomes of JD in
sheep. 12th International Colloquium on
Paratuberculosis, Italy: N/A.
Thirunavukkarasu, S., Plain, K., de Silva, K.,
Begg, D., Whittington, R., Purdie (Williams), A.
(2014). Expression of genes associated with
cholesterol and lipid metabolism identified as a
novel pathway in the early pathogenesis of
Mycobacterium avium subspecies
paratuberculosis - infection in cattle. Veterinary
Immunology and Immunopathology, 160(3-4),
147-157. <a
href="http://dx.doi.org/10.1016/j.vetimm.2014.0
4.002">[More Information]</a>
Plain, K., Marsh, I., Waldron, A., Galea, F.,
Whittington, A., Saunders, V., Begg, D., de
Silva, K., Purdie (Williams), A., Whittington, R.
(2014). High-Throughput Direct Faecal PCR
Assay to detection of Mycobacterium avium
subspecies paratuberculosis in sheep and cattle.
Journal of Clinical Microbiology, 52(3),
745-757. <a
href="http://dx.doi.org/10.1128/JCM.03233-13"
>[More Information]</a>
Publications for Kumudika de Silva
Bhardwaj, V., Dhungyel, O., de Silva, K.,
Whittington, R. (2014). Investigation of
immunity in sheep following footrot infection
and vaccination. Vaccine, 32(51), 6979-6985. <a
href="http://dx.doi.org/10.1016/j.vaccine.2014.1
0.031">[More Information]</a>
Gurung, R., Begg, D., Purdie (Williams), A., de
Silva, K., Bannantine, J., Whittington, R. (2014).
Lymphoproliferative and Gamma Interferon
responses to stress-regulated Mycobacterium
avium subspecies paratuberculosis recombinant
proteins. Clinical and Vaccine Immunology,
21(6), 831-837. <a
href="http://dx.doi.org/10.1128/CVI.00775-13">
[More Information]</a>
2013
de Silva, K., Browne, S., Begg, D., Whittington,
R., Emery, D. (2013). Apoptosis of lymph node
and peripheral blood cells in ovine Johne's
disease. Veterinary Immunology and
Immunopathology, 156(1-2), 82-90. <a
href="http://dx.doi.org/10.1016/j.vetimm.2013.0
8.001">[More Information]</a>
de Silva, K., Begg, D., Plain, K., Purdie
(Williams), A., Kawaji, S., Dhand, N.,
Whittington, R. (2013). Can early host responses
to mycobacterial infection predict eventual
disease outcomes? Preventive Veterinary
Medicine, 112, 203-212. <a
href="http://dx.doi.org/10.1016/j.prevetmed.201
3.08.006">[More Information]</a>
Thirunavukkarasu, S., Plain, K., Eckstein, T., de
Silva, K., Whittington, R. (2013). Cellular and
humoral immunogenicity of Mycobacterium
avium subsp. paratuberculosis specific
lipopentapeptide antigens. Research In
Veterinary Science, 95, 123-129. <a
href="http://dx.doi.org/10.1016/j.rvsc.2013.03.00
2">[More Information]</a>
Whittington, R., Whittington, A., Waldron, A.,
Begg, D., de Silva, K., Purdie (Williams), A.,
Plain, K. (2013). Development and validation of
a liquid medium (M7H9C) for routine culture of
Mycobacterium avium subsp. paratuberculosis to
replace modified Bactec 12B medium. Journal of
Clinical Microbiology, 51(12), 3993-4000. <a
href="http://dx.doi.org/10.1128/JCM.01373-13"
>[More Information]</a>
Thirunavukkarasu, S., de Silva, K., Whittington,
R., Plain, K. (2013). In vivo and in vitro
expression pattern of Toll-like receptors in
Mycobacterium avium subspecies
paratuberculosis infection. Veterinary
Immunology and Immunopathology, 156, 20-31.
<a
href="http://dx.doi.org/10.1016/j.vetimm.2013.0
8.008">[More Information]</a>
2012
Whittington, R., Begg, D., de Silva, K., Plain, K.,
Purdie (Williams), A. (2012). Comparative
immunological and microbiological aspects of
paratuberculosis as a model mycobacterial
infection. Veterinary Immunology and
Immunopathology, 148(1-2), 29-47. <a
href="http://dx.doi.org/10.1016/j.vetimm.2011.0
3.003">[More Information]</a>
Plain, K., Begg, D., de Silva, K., Purdie
(Williams), A., Whittington, R. (2012).
Enhancement of the interferon gamma assay to
detect
paratuberculosis using interleukin-7 and
interleukin-12 potentiation. Veterinary
Immunology and Immunopathology, 149(1-2),
28-37. <a
href="http://dx.doi.org/10.1016/j.vetimm.2012.0
5.023">[More Information]</a>
Purdie (Williams), A., Plain, K., Begg, D., de
Silva, K., Whittington, R. (2012). Expression of
genes associated with the antigen presentation
and processing pathway are consistently
regulated in early Mycobacterium avium subsp.
paratuberculosis infection. Comparative
Immunology, Microbiology and Infectious
Diseases: the international journal for medical
and veterinary researchers and practitioners,
35(2), 151-162. <a
href="http://dx.doi.org/10.1016/j.cimid.2011.12.
007">[More Information]</a>
2011
Purdie (Williams), A., Plain, K., Begg, D., de
Silva, K., Whittington, R. (2011). Candidate
gene and genome-wide association studies of
Mycobacterium avium subsp. paratuberculosis
infection in cattle and sheep: A review.
Comparative Immunology, Microbiology and
Infectious Diseases: the international journal for
medical and veterinary researchers and
practitioners, 34(3), 197-208. <a
href="http://dx.doi.org/10.1016/j.cimid.2010.12.
003">[More Information]</a>
Begg, D., de Silva, K., Carter, N., Plain, K.,
Purdie (Williams), A., Whittington, R. (2011).
Does a Th1 over Th2 dominancy really exist in
the early stages of Mycobacterium avium
subspecies paratuberculosis infections?
Immunobiology, 216(7), 840-846. <a
href="http://dx.doi.org/10.1016/j.imbio.2010.12.
004">[More Information]</a>
Bhardwaj, V., de Silva, K., Dhungyel, O.,
Whittington, R. (2011). Host Response to
Footrot Infection and Vaccination in Sheep.
Australian Society for Microbiology Annual
Scientific Meeting, N/A: N/A.
Plain, K., de Silva, K., Earl, J., Begg, D., Purdie
Publications for Kumudika de Silva
(Williams), A., Whittington, R. (2011).
Indoleamine 2,3-Dioxygenase, Tryptophan
Catabolism, and Mycobacterium avium subsp.
paratuberculosis: a model for Chronic
Mycobacterial Infection. Infection and Immunity,
79(9), 3821-3832. <a
href="http://dx.doi.org/10.1128/IAI.05204-11">[
More Information]</a>
de Silva, K., Begg, D., Whittington, R. (2011).
The interleukin 10 response in ovine Johne's
disease. Veterinary Immunology and
Immunopathology, 139(1), 10-16. <a
href="http://dx.doi.org/10.1016/j.vetimm.2010.0
7.022">[More Information]</a>
2010
Begg, D., de Silva, K., Plain, K., Purdie
(Williams), A., Whittington, R. (2010). Does a
Th1 over Th2 dominance exist in the early stages
of Mycobacterium avium subsp. paratuberculosis
infections? 9th IVIS International Veterinary
Immunology Symposium, Amsterdam: Elsevier.
Begg, D., de Silva, K., Di Fiore, L., Taylor, D.,
Bower (Goldsmith), K., Zhong, L., Kawaji, S.,
Emery, D., Whittington, R. (2010). Experimental
infection model for Johne's disease using a
lyophilised, pure culture, seedstock of
Mycobacterium avium subspecies
paratuberculosis. Veterinary Microbiology, 141,
301-311. <a
href="http://dx.doi.org/10.1016/j.vetmic.2009.09
.007">[More Information]</a>
de Silva, K., Begg, D., Plain, K., Purdie
(Williams), A., Kawaji, S., Whittington, R.
(2010). Immune correlates of protection and
susceptibility to mycobacterial disease. 41st
Australasian Society for Immunology Annual
Meeting, N/A: N/A.
de Silva, K., Begg, D., Kawaji, S., Plain, K.,
Whittington, R. (2010). Immune profile and
faecal shedding of Mycobacterium avium
paratuberculosis vary with lesion severity in
Johne’s disease. 9th IVIS International
Veterinary Immunology Symposium, Amsterdam:
Elsevier.
de Silva, K. (2010). Immune profile and fecal
shedding of Mycobacterium avium
paratuberculosis vary with lesion severity in
Johne's disease. 9th IVIS International
Veterinary Immunology Symposium, Amsterdam:
Elsevier.
Whittington, R., Begg, D., de Silva, K., Plain, K.,
Purdie (Williams), A. (2010). Immunological
characteristics of paratuberculosis as a
mycobacterial infection. 9th IVIS International
Veterinary Immunology Symposium, Amsterdam:
Elsevier.
Whittington, R., Begg, D., de Silva, K., Plain, K.,
Purdie (Williams), A. (2010). Mycobacterial
infection – lessons from tuberculosis and
paratuberculosis. 9th IVIS International
Veterinary Immunology Symposium, Amsterdam:
Elsevier.
Plain, K., de Silva, K., Earl, J., Begg, D., Purdie
(Williams), A., Whittington, R. (2010). Role of
IDO and tryptophan catabolism in chronic
mycobacterial disease pathogenesis. 41st
Australasian Society for Immunology Annual
Meeting, N/A: N/A.
de Silva, K., Begg, D., Carter, N., Taylor, D., Di
Fiore, L., Whittington, R. (2010). The early
lympocyte proliferation response in sheep
exposed to Mycobacterium avium subsp.
paratuberculosis compared to infection status.
Immunobiology, 215(1), 12-25. <a
href="http://dx.doi.org/10.1016/j.imbio.2009.01.
014">[More Information]</a>
Plain, K., Purdie (Williams), A., Begg, D., de
Silva, K., Whittington, R. (2010). Toll-like
receptor (TLR)6 and TLR1 differentiation in
gene expression studies of Johne's disease.
Veterinary Immunology and Immunopathology,
137(1-2), 142-148. <a
href="http://dx.doi.org/10.1016/j.vetimm.2010.0
4.002">[More Information]</a>
2009
Begg, D., de Silva, K., Di Fiore, L., Taylor, D.,
Bower (Goldsmith), K., Zhong, L., Kawaji, S.,
Emery, D., Whittington, R. (2009). Development
of an experimental infection model for Johne's
disease using a lyophilised pure culture
seedstock of Mycobacterium avium subspecies
paratuberculosis. 10th International Colloquium
on Paratuberculosis, Minnesota: University of
Minnesota.
Begg, D., Plain, K., Waldron, A., de Silva, K.,
Whittington, R. (2009). Development of an
Experimental Infection Model in Cattle using a
Low Passage Seed Stock of MAP. 10th
International Colloquium on Paratuberculosis,
Minnesota: University of Minnesota.
Plain, K., Begg, D., Waldron, A., de Silva, K.,
Whittington, R. (2009). Development of an
experimental infection protocol in cattle using a
low passage cultured strain of MAP. 10th
International Colloquium on Paratuberculosis,
USA: University of Minnesota.
Begg, D., de Silva, K., Bosward, K., Di Fiore, L.,
Taylor, D., Jungersen, G., Whittington, R.
(2009). Enzyme-linked immunospot: An
alternative method for the detection of interferon
gamma in Johne's disease. Journal of Veterinary
Diagnostic Investigation, 21(2), 187-196.
Zhong, L., Di Fiore, L., Taylor, D., Begg, D., de
Silva, K., Whittington, R. (2009). Identification
Publications for Kumudika de Silva
of differentially expressed genes in ileum,
intestinal lymph node and peripheral blood
mononuclear cells of sheep infected with
Mycobacterium avium subsp. paratuberculosis
using differential display polymerase chain
reaction. Veterinary Immunology and
Immunopathology, 131(3-4), 177-189. <a
href="http://dx.doi.org/10.1016/j.vetimm.2009.0
4.007">[More Information]</a>
de Silva, K., Begg, D., Whittington, R. (2009).
The early IL-10 response in ovine Johne's
disease. 10th International Colloquium on
Paratuberculosis, Minnesota: University of
Minnesota.
2008
Taylor, D., Zhong, L., Di Fiore, L., Begg, D., de
Silva, K., Whittington, R. (2008). Analysis of
Toll-like receptor gene expression in
Mycobacterium paratuberculosis infected sheep.
9th International Colloquium on
Paratuberculosis ICP 2007, United States:
International Association for Paratuberculosis.
Browne, S., de Silva, K., Begg, D., Whittington,
R., Emery, D. (2008). Apoptosis of mononuclear
cells in experimental and natural ovine Johne's
disease. 9th International Colloquium on
Paratuberculosis ICP 2007, United States:
International Association for Paratuberculosis.
Begg, D., Taylor, D., de Silva, K., Di Fiore, L.,
Whittington, R. (2008). Experimental infection
of sheep with M.avium subspecies
paratuberculosis: a brief review and introduction
to an Australian ovine challenge model. 9th
International Colloquium on Paratuberculosis
ICP 2007, United States: International
Association for Paratuberculosis.
de Silva, K., Begg, D., Taylor, D., Di Fiore, L.,
Whittington, R. (2008). Proliferation of
lymphocyte subsets in experimental ovine
Johne's disease. 9th International Colloquium on
Paratuberculosis ICP 2007, United States:
International Association for Paratuberculosis.
Begg, D., de Silva, K., Di Fiore, L., Taylor, D.,
Whittington, R. (2008). Seeing spots, developing
an IFN-gamma ELISPOT assay to detect ovine
M. avium subspecies paratuberculosis infection.
9th International Colloquium on
Paratuberculosis ICP 2007, United States:
International Association for Paratuberculosis.
Begg, D., de Silva, K., Whittington, R. (2008).
The IFN-g to antibody switch - does it really
happen in Mycobacterium paratuberculosis
infections? The 38th Australasian Society for
Immunology Annual Conference ASI 2008,
Australia: Australasian Society for Immunology.
Taylor, D., Zhong, L., Begg, D., de Silva, K.,
Whittington, R. (2008). Toll-like receptor genes
are differentially expressed at the sites of
infection during the progression of Johne's
disease in outbred sheep. Veterinary Immunology
and Immunopathology, 124, 132-151. <a
href="http://dx.doi.org/10.1016/j.vetimm.2008.0
2.021">[More Information]</a>
2007
Taylor, D., Thomson, P., de Silva, K.,
Whittington, R. (2007). Validation of
endogenous reference genes for expression
profiling of RAW264.7 cells infected with
Mycobacterium avium subsp. paratuberculosis
by quantitive PCR. Veterinary Immunology and
Immunopathology, 115, 43-55.
2006
Di Fiore, L., Taylor, D., de Silva, K., Bosward,
K., Begg, D., Emery, D., Whittington, R. (2006).
Identificaiton of differentially expressed genes in
uninfected and Mycobacterium paratuberculosis
(M.ptb. ) infected sheep. The 8th International
Colloquium on Paratuberculosis, N/A: N/A.
Di Fiore, L., Taylor, D., de Silva, K., Bosward,
K., Begg, D., Emery, D., Whittington, R. (2006).
Identification of differentially expressed genes in
uninfected and Mycobacterium paratuberculosis
(M. ptb.) infected sheep. 8th International
Colloquium on Paratuberculosis ICP 2005,
United States: International Association for
Paratuberculosis.
Bosward, K., Begg, D., de Silva, K., Di Fiore, L.,
Taylor, D., Emery, D., Whittington, R. (2006).
Optimisation of the interferon-gamma assay to
maximise responses to M. ptb. antigen in sheep.
8th International Colloquium on
Paratuberculosis ICP 2005, United States:
International Association for Paratuberculosis.
Begg, D., de Silva, K., Di Fiore, L., Taylor, D.,
Whittington, R. (2006). Seeing spots, using the
ELISPOT assay to detect M. avium subspecies
paratuberculosis infection in sheep. Australasian
Society for Immunology Conference 2006,
Australia: Australasian Society for Immunology.
2005
Browne, S., de Silva, K., Whittington, R.,
Emery, D. (2005). Apoptosis in sheep exposed to
Mycobacterium avium paratuberculosis.
Apoptosis and Immunity Conference, Melbourne,
Victoria, Australia: Peter MacCallum Cancer
Centre.
Browne, S., de Silva, K., Whittington, R.,
Emery, D. (2005). Apoptotic responses during
the pathogenesis of ovice Johne's disease. MLA
OJD Harvest Year Conference, North Sydney,
N.S.W: Meat & Livestock Australia Ltd.
de Silva, K., Begg, D., Di Fiore, L., Taylor, D.,
Emery, D., Whittington, R. (2005). Early cellular
Publications for Kumudika de Silva
responses in ovine Johne's disease. MLA OJD
Harvest Year Conference, North Sydney, N.S.W:
Meat & Livestock Australia Ltd.
Begg, D., Bosward, K., de Silva, K., Di Fiore, L.,
Taylor, D., Whittington, R. (2005). ELISPOT new methods for detecting IFN-y. MLA OJD
Harvest Year Conference, North Sydney, N.S.W:
Meat & Livestock Australia Ltd.
Taylor, D., de Silva, K., Di Fiore, L.,
Whittington, R. (2005). Gene expression and
survival of M. paratuberculosis infected
macrophages. 8th International Colloquium on
Paratuberculosis ICP 2005, United States:
International Association for Paratuberculosis.
Di Fiore, L., Taylor, D., de Silva, K., Bosward,
K., McGregor, H., Whittington, R. (2005). Gene
expression signals from the host. MLA OJD
Harvest Year Conference, North Sydney, N.S.W:
Meat & Livestock Australia Ltd.
Bosward, K., Begg, D., de Silva, K., Di Fiore, L.,
Taylor, D., Whittington, R. (2005). Manipulation
of the Interferon - gamma assay to maximise
responses to M. ptb antigen in sheep. MLA OJD
Harvest Year Conference, North Sydney, N.S.W:
Meat & Livestock Australia Ltd.
Taylor, D., Gumber, S., de Silva, K., Bower
(Goldsmith), K., Di Fiore, L., Begg, D.,
Whittington, R. (2005). Molecular approaches to
studying the host-parasite interaction. MLA OJD
Harvest Year Conference, North Sydney, N.S.W:
Meat & Livestock Australia Ltd.
Browne, S., de Silva, K., Whittington, R.,
Emery, D. (2005). Ovine apoptotic responses to
Mycobacterium avium paratuberculosis. 8th
International Colloquium on Paratuberculosis
ICP 2005, United States: International
Association for Paratuberculosis.
de Silva, K., Carter, N., Taylor, D., Di Fiore, L.,
Whittington, R., Emery, D. (2005). Proliferative
responses in peripheral blood and lymph node
cells in the early stages of ovine Johne's disease.
8th International Colloquium on
Paratuberculosis ICP 2005, United States:
International Association for Paratuberculosis.
2003
de Silva, K., Daud, A., Deng, J., Jones, S.,
Gamelli, R., Shankar, R. (2003). Prostaglandin
E2 mediates growth arrest in NFS-60 cells by
down-regulating interleukin-6 receptor
expression. Biochemical Journal, 370(1),
315-321.