Publications for Damian Holsinger 2016

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Publications for Damian Holsinger
Publications for Damian Holsinger
2016
Rollo, J., Banihashemi, N., Vafaee, F., Crawford,
J., Kuncic, Z., Holsinger, D. (2016). Unraveling
the mechanistic complexity of Alzheimer’s
disease through systems biology. Alzheimer's
and Dementia, In Press. <a
href="http://dx.doi.org/10.1016/j.jalz.2015.10.01
0">[More Information]</a>
2015
Holsinger, D. (2015). Translation of low-risk
dementia-associated interventions into practice- a
call to action. Healthy Aging Research, 4(30),
1-9. <a
href="http://dx.doi.org/10.12715/har.2015.4.30"
>[More Information]</a>
2014
Thompson, G., Ireland, T., Larkin, X., Arnold, J.,
Holsinger, D. (2014). A Novel
Segmentation-Based Algorithm for the
Quantification of Magnified Cells. Journal Of
Cellular Biochemistry, 115, 1849-1854. <a
href="http://dx.doi.org/10.1002/jcb.24882">[Mo
re Information]</a>
Buljan, V., Holsinger, D., Hambly, B., Kanellis,
V., Matar, E., Larkin, X., Liu, G.,
Bohorquez-Florez, J., Banati, R. (2014). Intrinsic
synergistic-topological mechanism versus
synergistic-topological matrix in microtubule
self-organization. EPJ Nonlinear Biomedical
Physics, 2, 1-28.
Sajjan, S., Holsinger, D., Fok, S., Ebrahimkhani,
S., Rollo, J., Banati, R., Graeber, M. (2014).
Up-regulation of matrix metallopeptidase 12 in
motor neurons undergoing synaptic stripping.
Neuroscience, 274, 331-340. <a
href="http://dx.doi.org/10.1016/j.neuroscience.2
014.05.052">[More Information]</a>
2013
Holsinger, D., Petersen, G., Hilbert, B., Strappe,
P. (2013). Generation of induced neuronal cells
from adult stem cells for tissue engineering
applications by lentiviral vector expression of
transcription factors. Australian Society of
Biomaterials and Tissue Engineering (ASBTE),
Tanunda, Barossa Valley, South Australia:
ASBTE.
Buljan, V., Holsinger, D., Hambly, B., Banati,
R., Ivanova, E. (2013). Intrinsic microtubule
GTP-cap dynamics in semi-confined systems:
kinetochore-microtubule interface. Journal of
Biological Physics, 39(1), 81-98. <a
href="http://dx.doi.org/10.1007/s10867-012-928
7-3">[More Information]</a>
Kosaraju, J., Gali, C., Khatwal, R., Dubala, A.,
Chinni, S., Holsinger, D., Madhunapantula, V.,
Nataraj, S., Basavan, D. (2013). Saxagliptin: A
dipeptidyl peptidase-4 inhibitor ameliorates
streptozotocin induced Alzheimer's disease.
Neuropharmacology, 72, 291-300. <a
href="http://dx.doi.org/10.1016/j.neuropharm.20
13.04.008">[More Information]</a>
Buljan, V., Holsinger, D., Brown, D.,
Bohorquez-Florez, J., Hambly, B., Delikatny, E.,
Ivanova, E., Banati, R. (2013). Spinodal
decomposition and the emergence of dissipative
transient periodic spatio-temporal patterns in
acentrosomal microtubule multitudes of different
morphology. Chaos, 23(2), 1-16. <a
href="http://dx.doi.org/10.1063/1.4807909">[Mo
re Information]</a>
Holsinger, D., Goense, N., Bohorquez-Florez, J.,
Strappe, P. (2013). Splice variants of the
Alzheimer’s disease beta-secretase, BACE1.
Neurogenetics, 14(1), 1-9. <a
href="http://dx.doi.org/10.1007/s10048-012-034
8-3">[More Information]</a>
Li, W., Holsinger, D., Kruse, C., Flugel, A.,
Graeber, M. (2013). The Potential for
Genetically Altered Microglia to Influence
Glioma Treatment. CNS & Neurological
Disorders - Drug Targets, 12(6), 750-762. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=24047526">[More Information]</a>
Sajjan, S., Holsinger, D., Fok, S., Banati, R.,
Greaber, M. (2013). Up-regulation of matrix
metallopeptidase 12 in motor neurons
undergoing synaptic stripping. Sydney
Neuroscience Network, Neuroscience and
Mental Health Symposium, Sydney, NSW.
2012
Holsinger, D., Chua, Y., Goense, N., Alomari,
M., Rao, G., Bohorquez, J., Chen, Y. (2012). A
novel BACE1-regulating protein with therapeutic
potential. Alzheimer’s Association Internatonal
Conference 2012, Vancouver, Canada.:
Alzheimer’s Association Internatonal
Conference 2012.
Holsinger, D., Li, W., Graeber, M. (2012).
Microglia as a therapeutic target in glioma.
Personalised Medicine Workshop - HMRI,
University of Newcastle NSW: Personalised
Medicine Workshop HMRI.
Holsinger, D., Brown, R., Richmond, R.,
Kay-Lambkin, F., Kirby, A., Chan, D. (2012).
Prevalence of the long-allele genotype of the
serotonin transporter-linked gene in female
centenarians. Journal of the American Geriatrics
Society, 60(9), 1786-1788. <a
href="http://dx.doi.org/10.1111/j.1532-5415.201
2.04127.x">[More Information]</a>
Publications for Damian Holsinger
Holsinger, D., Li, W., Garebar, M. (2012). The
need for multidimensional tissue analysis:
Alzheimer's disease as an example. Biomarker
Discovery Conference 2012, Shoal Bay NSW:
Biomarker Discovery Conference 2012.
2010
George, A., Gordon, L., Beissbarth, T.,
Koukoulas, I., Holsinger, D., Perreau, V.,
Cappai, R., Tan, S., Masters, C., Scott, H., et al
(2010). A Serial Analysis of Gene Expression
Profile of the Alzheimer's Disease Tg2576
Mouse Model. Neurotoxicity Research, 17,
360-379. <a
href="http://dx.doi.org/10.1007/s12640-009-911
2-3">[More Information]</a>
2009
Kassiou, M., Banati, R., Holsinger, D., Meikle,
S. (2009). Challenges in molecular imaging of
Parkinson's disease: A brief overview. Brain
Research Bulletin, 78(2-3), 105-108. <a
href="http://dx.doi.org/10.1016/j.brainresbull.20
08.08.006">[More Information]</a>
2008
Holsinger, D., Alomari, M. (2008). An
endogenous regulator decreases levels of the
Alzheimer’s disease BACE1. Society of
Neuroscience Abstract, Washington DC USA:
Society of Neuroscience Abstract.
Einfeld, S., Goetz, J., Holsinger, D. (2008).
Pathogenetic mechanisms in Down Syndrome.
Journal of Intellectual Disability Research,
52(10), 813-813. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=19017146">[More Information]</a>
Einfeld, S., Goetz, J., Holsinger, R. (2008). Two
novel genes associated with Down’s syndrome.
Journal of Intellectual Disability Research,
52(10), 813.
2006
George, A., Gordon, L., Beissbarth, T.,
Koukoulase, L., Holsinger, R., Perreaua, V.,
Cappai, R., Tan, S., Masters, C., Scott, H., et al
(2006). A Serial Analysis of Gene Expression
(SAGE) profile of the Alzheimer’s disease
Tg2576 mouse model. The 10th International
Conference on Alzheimer’s Disease and Related
Disorders, Madrid, Spain: The 10th International
Conference on Alzheimer’s Disease and Related
Disorders.
White, A., Du, T., Laughton, K., Volitakis, I.,
Sharples, R., Hoke, D., Holsinger, R., Evin, G.,
Cherny, R., Hill, A., et al (2006). Clioquinol
induces metal-dependent degradation of the
Alzheimer's disease amyloid beta peptide by
up-regulation of matrix metalloproteases.
Journal of Neurochemistry, 98(90).
Holsinger, D., Lee, J., Boyd, A., Masters, C.,
Collins, S. (2006). CSF BACE1 activity is
increased in CJD and Alzheimer disease other
dementias. Neurology, 67(4), 710-712. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16924032">[More Information]</a>
George, A., Holsinger, D., McLean, C., Tan, S.,
Scott, H., Cardamone, T., Cappai, R., Masters,
C., Li, Q. (2006). Decreased
phosphatidylethanolamine binding protein
expression correlates with Aβ accumulation in
the
Tg2576 mouse model of Alzheimer's disease.
Neurobiology of Aging, 27(4), 614-623. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15941609">[More Information]</a>
White, A., Du, T., Laughton, K., Volitakis, I.,
Sharples, R., Xilinas, M., Hoke, D., Holsinger,
D., Evin, G., Cherny, R., et al (2006).
Degradation of the Alzheimer disease amyloid
beta-peptide by metal-dependent up-regulation of
metalloprotease activity. Journal of Biological
Chemistry, 281(26), 17670-17680. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16648635">[More Information]</a>
Beckman, M., Holsinger, D., Small, D. (2006).
Heparin activates beta-secretase (BACE1) of
Alzheimer's disease and increases autocatalysis
of the enzyme. Biochemistry, 45(21), 6703-6714.
<a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16716081">[More Information]</a>
Small, D., Holsinger, R., Beckman, M. (2006).
Heparin activates β-secertase (BACE1) of
Alzheimer’s disease and increases autocatalysis
of the enzyme. The 10th International
Conference on Alzheimer’s Disease and Related
Disorders, Madrid, Spain: The 10th International
Conference on Alzheimer’s Disease and Related
Disorders.
2005
Mok, S., Holsinger, R., Li, Q., Cappai, R.,
Masters, C., Culvenor, J. (2005).
Alpha-synuclein mutations increase sensitivity of
human neuroblastoma cells to cytotoxicity.
Journal of Neurochemistry, 94, 118-118.
Mok, S., Holsinger, R., Li, Q., Cappai, R.,
Masters, C., Culvenor, J. (2005). Effect of
pathogenic alpha-synucleain mutations on
sensitivity of human neuroblastoma cells to
Publications for Damian Holsinger
toxicity. 7th International Conference AD/PD,
Sorrento, Italy: 7th International Conference
AD/PD.
Holsinger, R., Saez-Valero, J., Lee, J., Collins,
S., Masters, C., Evin, G. (2005). Evaluating
BACE 1 as a diagnostic marker for Alzheimer’s
disease. 7th International Conference AD/PD,
Sorrento, Italy: 7th International Conference
AD/PD.
Holsinger, D., McLean, C., Collins, S., Masters,
C., Evin, G. (2004). Increased β-secretase
activity in cerebrospinal fluid of Alzheimer's
disease subjects. Annals of Neurology, 55(6),
898-899. <a
href="http://dx.doi.org/10.1002/ana.20144">[Mo
re Information]</a>
2003
Chua, Y., Helfenbaum, L., Masters, C., Evin, G.,
Holsinger, R. (2005). Identification of Proteins
Interacting with the Alzheimer’s Disease
β-secretase Enzyme, BACE1. Society of
Neuroscience Abstract, Washington DC USA:
Society of Neuroscience Abstract.
Evin, G., Canterford, L., Holsinger, R., Masters,
C. (2003). Analysis of Alzheimer's Disease
gamma-Secretase Complex Using Biotinylated
Inhibitors. International Conference on Aspartic
Proteases and Inhibitors, Kyoto, Japan.:
International Conference on Aspartic Proteases
and Inhibitors.
White, A., Du, T., Hill, A., Sharples, R.,
Barnham, K., Holsinger, R., Ciccotosto, G.,
Hoke, D., Evin, G., Laughton, K., et al (2005).
Modulation of APP and Aβ metabolism by metal
chelators. ISN and ESN 20th Biennial Meeting,
Insbruck, Austria: ISN and ESN 20th Biennial
Meeting.
Holsinger, R., Chua, Y., Masters, C., Evin, G.
(2003). Detection of the Alzheimer’s disease β
secretase enzyme, BACE, using different
extraction techniques. Society for Neuroscience
Abstracts 2003, New Orleans, USA: Society for
Neuroscience Abstract.
Holsinger, R., Tan, N., Masters, C., Evin, G.,
Tan, J. (2005). Suppression of the Alzheimer’s
disease BACE1 by RNA interference. Society of
Neuroscience Abstract, Washington DC USA:
Society of Neuroscience Abstract.
2004
Holsinger, R., McLean, C., Masters, C., Evin, G.
(2004). Analysis of BACE protein and activity in
human cerebrospinal fluid. Neurobiology of
Aging, 25, 528-528.
George, A., Holsinger, D., McLean, C.,
Laughton, K., Beyreuther, K., Evin, G., Masters,
C., Li, Q. (2004). APP intracellular domain is
increased and soluble Abeta is reduced with
diet-induced hypercholesterolemia in a
transgenic mouse model of Alzheimer disease.
Neurobiology of Disease, 16(1), 124-132. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=15207269">[More Information]</a>
George, A., Holsinger, R., McLean, C.,
Laughton, K., Evin, G., Masters, C., Li, Q.
(2004). Dietary cholesterol regulates APP
processing in the Alzheimer's transgenic mouse
model. Australian Neuroscience Society,
Melbourne, Victoria Australia: Australian
Neuroscience Society.
Evin, G., Canterford, L., Hoke, D., Holsinger, R.,
Culvenor, J., Masters, C. (2004).
Gamma-secretase inhibitors stabilize a 900 KDA
presenilin complex: A tetrameric model for
gamma-secretase. Neurobiology of Aging, 25,
558-558. <a
href="http://dx.doi.org/10.1016/S0197-4580(04)
81850-5">[More Information]</a>
Evin, G., Culvenor, J., Sernee, M., Hoke, D.,
Canterford, L., Holsinger, R., Cappai, R.,
Beyreuther, K., Masters, C. (2003).
Gamma-secretase processing of APP
transmembravpmne domain. 6th International
Conference AD/PD, Seville, Spain: 6th
International Conference AD/PD.
Evin, G., Zhu, A., Holsinger, D., Masters, C., Li,
Q. (2003). Proteolytic processing of the
Alzheimer's Disease amyloid precursor protein in
brain and platelets. Journal of Neuroscience
Research, 74, 386-392. <a
href="http://dx.doi.org/10.1002/jnr.10745">[Mor
e Information]</a>
Holsinger, R., Cullen, K., Culvenor, J., Roytta,
K., Canterford, L., Masters, C., Evin, G. (2003).
Redefinition of BACE1 transmembrane domain
to include residues 455-460. International
Conference on Aspartic Proteases and
Inhibitors, Kyoto, Japan.: International
Conference on Aspartic Proteases and Inhibitors.
Holsinger, R., Cullen, K., Culvenor, J., Roytta,
K., Masters, C., Evin, G. (2003). Redefinition of
BACE1 transmembrane domain to include
residues 455-460. 28th Lorne Conference on
Protein Structure and Function, Victoria,
Australia: 28th Lorne Conference on Protein
Structure and Function.
George, A., Holsinger, R., McLean, C.,
Laughton, K., Beyreuther, K., Evin, G., Masters,
C., Li, Q. (2003). Regulation of APP processing
in the Alzheimer’s transgenic mouse model with
diet-induced hypercholesterolemia. Combio 2003
ASBMB, Melbourne, Australia: Combio 2003
ASBMB.
2002
Publications for Damian Holsinger
Evin, G., Holsinger, R., Canterford, L., Hoke, D.,
Masters, C., Eggert, S., Weidemann, A.,
Beyreuther, K. (2002). APP C-terminal
fragments in Alzheimer's disease brain.
Neurobiology of Aging, 23(1), 656.
Holsinger, R., McLean, C., Masters, C., Evin, G.,
Beyreuther, K. (2002). BACE and beta-secretase
product CTF beta are increased in sporadic
Alzheimer's disease brain. Neurobiology of
Aging, 23(1), 663.
Evin, G., Holsinger, R., Eggert, S., Weidmann,
A., Canterford, L., Hoke, D., Gandy, S.,
McLean, C., Beyreuther, K., Masters, C. (2002).
Carboxyl-terminal fragments of the amyloid
precursor protein in Alzheimer’s disease brain:
detection of γ-secretase products. Brain Aging
International Journal, 29(3), 61-66.
Holsinger, D., McLean, C., Beyreuther, K.,
Masters, C., Evin, G. (2002). Increased
expression of the amyloid precursor beta
secretase in Alzheimer's Disease. Annals of
Neurology, 51(6), 783-786. <a
href="http://dx.doi.org/10.1002/ana.10208">[Mo
re Information]</a>
Evin, G., Sernee, M., Barnham, K., Holsinger,
R., Culvenor, J., Hoke, D., Li, Q., et al (2002).
Modulation of Alzheimer's disease Aβ pathways
for rational therapeutic intervention: secretase
inhibition and metalloprotein active compounds.
In K. Iqbal and B Winblad (Eds.), Alzheimer’s
disease and related disorders: Research
advances, (pp. 513-523). Bucharest, Romania:
"Ana Alsan" International Academy of Aging.
Fahnestock, M., Garzon, D., Holsinger, D.,
Michalski, B. (2002). Neurotrophic factors and
Alzheimer's disease: are we focusing on the
wrong molecule? Journal of Neural
Transmission, 62(suppl.), 239-252.
2001
Evin, G., Sharples, R., Weidemann, A.,
Reinhard, F., Carbone, V., Culvenor, J.,
Holsinger, D., Sernee, M., Beyreuther, K.,
Masters, C. (2001). Aspartyl protease inhibitor
pepstatin binds to the presenilins of Alzheimer's
disease. Biochemistry, 62, 239-250.
Holsinger, R., McLean, C., Beyreuther, K.,
Masters, C., Evin, G. (2001). Increased BACE
Immunoreactivity in Alzheimer’s Disease Brain.
Society for Neuroscience Abstract 2001, San
Diego, USA: Society for Neuroscience Abstract
2001.
2000
Holsinger, R., Schnarr, J., Henry, P., Castelo, V.,
Fahnestock, M. (2000). Quantitation of BDNF
mRNA in human parietal cortex by competitive
reverse transcription-polymerase chain reaction:
decreased levels in Alzheimer's disease.
Molecular Brain Research, 76(2), 347-354.
Holsinger, R., Cappai, R., McLean, C., Smith,
M., Reinhard, F., Multhaup, G., Weidemann, A.,
Beyreuther, K., Masters, C., Evin, G. (2000).
Quantitative analysis of BACE1 in normal and
Alzheimer’s disease brain. Society for
Neuroscience Abstract 2000, New Orleans USA:
Society for Neuroscience Abstract 2000.
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