Publications for Damian Holsinger Publications for Damian Holsinger 2016 Rollo, J., Banihashemi, N., Vafaee, F., Crawford, J., Kuncic, Z., Holsinger, D. (2016). Unraveling the mechanistic complexity of Alzheimer’s disease through systems biology. Alzheimer's and Dementia, In Press. <a href="http://dx.doi.org/10.1016/j.jalz.2015.10.01 0">[More Information]</a> 2015 Holsinger, D. (2015). Translation of low-risk dementia-associated interventions into practice- a call to action. Healthy Aging Research, 4(30), 1-9. <a href="http://dx.doi.org/10.12715/har.2015.4.30" >[More Information]</a> 2014 Thompson, G., Ireland, T., Larkin, X., Arnold, J., Holsinger, D. (2014). A Novel Segmentation-Based Algorithm for the Quantification of Magnified Cells. Journal Of Cellular Biochemistry, 115, 1849-1854. <a href="http://dx.doi.org/10.1002/jcb.24882">[Mo re Information]</a> Buljan, V., Holsinger, D., Hambly, B., Kanellis, V., Matar, E., Larkin, X., Liu, G., Bohorquez-Florez, J., Banati, R. (2014). Intrinsic synergistic-topological mechanism versus synergistic-topological matrix in microtubule self-organization. EPJ Nonlinear Biomedical Physics, 2, 1-28. Sajjan, S., Holsinger, D., Fok, S., Ebrahimkhani, S., Rollo, J., Banati, R., Graeber, M. (2014). Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Neuroscience, 274, 331-340. <a href="http://dx.doi.org/10.1016/j.neuroscience.2 014.05.052">[More Information]</a> 2013 Holsinger, D., Petersen, G., Hilbert, B., Strappe, P. (2013). Generation of induced neuronal cells from adult stem cells for tissue engineering applications by lentiviral vector expression of transcription factors. Australian Society of Biomaterials and Tissue Engineering (ASBTE), Tanunda, Barossa Valley, South Australia: ASBTE. Buljan, V., Holsinger, D., Hambly, B., Banati, R., Ivanova, E. (2013). Intrinsic microtubule GTP-cap dynamics in semi-confined systems: kinetochore-microtubule interface. Journal of Biological Physics, 39(1), 81-98. <a href="http://dx.doi.org/10.1007/s10867-012-928 7-3">[More Information]</a> Kosaraju, J., Gali, C., Khatwal, R., Dubala, A., Chinni, S., Holsinger, D., Madhunapantula, V., Nataraj, S., Basavan, D. (2013). Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease. Neuropharmacology, 72, 291-300. <a href="http://dx.doi.org/10.1016/j.neuropharm.20 13.04.008">[More Information]</a> Buljan, V., Holsinger, D., Brown, D., Bohorquez-Florez, J., Hambly, B., Delikatny, E., Ivanova, E., Banati, R. (2013). Spinodal decomposition and the emergence of dissipative transient periodic spatio-temporal patterns in acentrosomal microtubule multitudes of different morphology. Chaos, 23(2), 1-16. <a href="http://dx.doi.org/10.1063/1.4807909">[Mo re Information]</a> Holsinger, D., Goense, N., Bohorquez-Florez, J., Strappe, P. (2013). Splice variants of the Alzheimer’s disease beta-secretase, BACE1. Neurogenetics, 14(1), 1-9. <a href="http://dx.doi.org/10.1007/s10048-012-034 8-3">[More Information]</a> Li, W., Holsinger, D., Kruse, C., Flugel, A., Graeber, M. (2013). The Potential for Genetically Altered Microglia to Influence Glioma Treatment. CNS & Neurological Disorders - Drug Targets, 12(6), 750-762. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=24047526">[More Information]</a> Sajjan, S., Holsinger, D., Fok, S., Banati, R., Greaber, M. (2013). Up-regulation of matrix metallopeptidase 12 in motor neurons undergoing synaptic stripping. Sydney Neuroscience Network, Neuroscience and Mental Health Symposium, Sydney, NSW. 2012 Holsinger, D., Chua, Y., Goense, N., Alomari, M., Rao, G., Bohorquez, J., Chen, Y. (2012). A novel BACE1-regulating protein with therapeutic potential. Alzheimer’s Association Internatonal Conference 2012, Vancouver, Canada.: Alzheimer’s Association Internatonal Conference 2012. Holsinger, D., Li, W., Graeber, M. (2012). Microglia as a therapeutic target in glioma. Personalised Medicine Workshop - HMRI, University of Newcastle NSW: Personalised Medicine Workshop HMRI. Holsinger, D., Brown, R., Richmond, R., Kay-Lambkin, F., Kirby, A., Chan, D. (2012). Prevalence of the long-allele genotype of the serotonin transporter-linked gene in female centenarians. Journal of the American Geriatrics Society, 60(9), 1786-1788. <a href="http://dx.doi.org/10.1111/j.1532-5415.201 2.04127.x">[More Information]</a> Publications for Damian Holsinger Holsinger, D., Li, W., Garebar, M. (2012). The need for multidimensional tissue analysis: Alzheimer's disease as an example. Biomarker Discovery Conference 2012, Shoal Bay NSW: Biomarker Discovery Conference 2012. 2010 George, A., Gordon, L., Beissbarth, T., Koukoulas, I., Holsinger, D., Perreau, V., Cappai, R., Tan, S., Masters, C., Scott, H., et al (2010). A Serial Analysis of Gene Expression Profile of the Alzheimer's Disease Tg2576 Mouse Model. Neurotoxicity Research, 17, 360-379. <a href="http://dx.doi.org/10.1007/s12640-009-911 2-3">[More Information]</a> 2009 Kassiou, M., Banati, R., Holsinger, D., Meikle, S. (2009). Challenges in molecular imaging of Parkinson's disease: A brief overview. Brain Research Bulletin, 78(2-3), 105-108. <a href="http://dx.doi.org/10.1016/j.brainresbull.20 08.08.006">[More Information]</a> 2008 Holsinger, D., Alomari, M. (2008). An endogenous regulator decreases levels of the Alzheimer’s disease BACE1. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract. Einfeld, S., Goetz, J., Holsinger, D. (2008). Pathogenetic mechanisms in Down Syndrome. Journal of Intellectual Disability Research, 52(10), 813-813. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=19017146">[More Information]</a> Einfeld, S., Goetz, J., Holsinger, R. (2008). Two novel genes associated with Down’s syndrome. Journal of Intellectual Disability Research, 52(10), 813. 2006 George, A., Gordon, L., Beissbarth, T., Koukoulase, L., Holsinger, R., Perreaua, V., Cappai, R., Tan, S., Masters, C., Scott, H., et al (2006). A Serial Analysis of Gene Expression (SAGE) profile of the Alzheimer’s disease Tg2576 mouse model. The 10th International Conference on Alzheimer’s Disease and Related Disorders, Madrid, Spain: The 10th International Conference on Alzheimer’s Disease and Related Disorders. White, A., Du, T., Laughton, K., Volitakis, I., Sharples, R., Hoke, D., Holsinger, R., Evin, G., Cherny, R., Hill, A., et al (2006). Clioquinol induces metal-dependent degradation of the Alzheimer's disease amyloid beta peptide by up-regulation of matrix metalloproteases. Journal of Neurochemistry, 98(90). Holsinger, D., Lee, J., Boyd, A., Masters, C., Collins, S. (2006). CSF BACE1 activity is increased in CJD and Alzheimer disease other dementias. Neurology, 67(4), 710-712. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=16924032">[More Information]</a> George, A., Holsinger, D., McLean, C., Tan, S., Scott, H., Cardamone, T., Cappai, R., Masters, C., Li, Q. (2006). Decreased phosphatidylethanolamine binding protein expression correlates with Aβ accumulation in the Tg2576 mouse model of Alzheimer's disease. Neurobiology of Aging, 27(4), 614-623. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15941609">[More Information]</a> White, A., Du, T., Laughton, K., Volitakis, I., Sharples, R., Xilinas, M., Hoke, D., Holsinger, D., Evin, G., Cherny, R., et al (2006). Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity. Journal of Biological Chemistry, 281(26), 17670-17680. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=16648635">[More Information]</a> Beckman, M., Holsinger, D., Small, D. (2006). Heparin activates beta-secretase (BACE1) of Alzheimer's disease and increases autocatalysis of the enzyme. Biochemistry, 45(21), 6703-6714. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=16716081">[More Information]</a> Small, D., Holsinger, R., Beckman, M. (2006). Heparin activates β-secertase (BACE1) of Alzheimer’s disease and increases autocatalysis of the enzyme. The 10th International Conference on Alzheimer’s Disease and Related Disorders, Madrid, Spain: The 10th International Conference on Alzheimer’s Disease and Related Disorders. 2005 Mok, S., Holsinger, R., Li, Q., Cappai, R., Masters, C., Culvenor, J. (2005). Alpha-synuclein mutations increase sensitivity of human neuroblastoma cells to cytotoxicity. Journal of Neurochemistry, 94, 118-118. Mok, S., Holsinger, R., Li, Q., Cappai, R., Masters, C., Culvenor, J. (2005). Effect of pathogenic alpha-synucleain mutations on sensitivity of human neuroblastoma cells to Publications for Damian Holsinger toxicity. 7th International Conference AD/PD, Sorrento, Italy: 7th International Conference AD/PD. Holsinger, R., Saez-Valero, J., Lee, J., Collins, S., Masters, C., Evin, G. (2005). Evaluating BACE 1 as a diagnostic marker for Alzheimer’s disease. 7th International Conference AD/PD, Sorrento, Italy: 7th International Conference AD/PD. Holsinger, D., McLean, C., Collins, S., Masters, C., Evin, G. (2004). Increased β-secretase activity in cerebrospinal fluid of Alzheimer's disease subjects. Annals of Neurology, 55(6), 898-899. <a href="http://dx.doi.org/10.1002/ana.20144">[Mo re Information]</a> 2003 Chua, Y., Helfenbaum, L., Masters, C., Evin, G., Holsinger, R. (2005). Identification of Proteins Interacting with the Alzheimer’s Disease β-secretase Enzyme, BACE1. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract. Evin, G., Canterford, L., Holsinger, R., Masters, C. (2003). Analysis of Alzheimer's Disease gamma-Secretase Complex Using Biotinylated Inhibitors. International Conference on Aspartic Proteases and Inhibitors, Kyoto, Japan.: International Conference on Aspartic Proteases and Inhibitors. White, A., Du, T., Hill, A., Sharples, R., Barnham, K., Holsinger, R., Ciccotosto, G., Hoke, D., Evin, G., Laughton, K., et al (2005). Modulation of APP and Aβ metabolism by metal chelators. ISN and ESN 20th Biennial Meeting, Insbruck, Austria: ISN and ESN 20th Biennial Meeting. Holsinger, R., Chua, Y., Masters, C., Evin, G. (2003). Detection of the Alzheimer’s disease β secretase enzyme, BACE, using different extraction techniques. Society for Neuroscience Abstracts 2003, New Orleans, USA: Society for Neuroscience Abstract. Holsinger, R., Tan, N., Masters, C., Evin, G., Tan, J. (2005). Suppression of the Alzheimer’s disease BACE1 by RNA interference. Society of Neuroscience Abstract, Washington DC USA: Society of Neuroscience Abstract. 2004 Holsinger, R., McLean, C., Masters, C., Evin, G. (2004). Analysis of BACE protein and activity in human cerebrospinal fluid. Neurobiology of Aging, 25, 528-528. George, A., Holsinger, D., McLean, C., Laughton, K., Beyreuther, K., Evin, G., Masters, C., Li, Q. (2004). APP intracellular domain is increased and soluble Abeta is reduced with diet-induced hypercholesterolemia in a transgenic mouse model of Alzheimer disease. Neurobiology of Disease, 16(1), 124-132. <a href="http://www.ncbi.nlm.nih.gov/entrez/query. fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract &list_uids=15207269">[More Information]</a> George, A., Holsinger, R., McLean, C., Laughton, K., Evin, G., Masters, C., Li, Q. (2004). Dietary cholesterol regulates APP processing in the Alzheimer's transgenic mouse model. Australian Neuroscience Society, Melbourne, Victoria Australia: Australian Neuroscience Society. Evin, G., Canterford, L., Hoke, D., Holsinger, R., Culvenor, J., Masters, C. (2004). Gamma-secretase inhibitors stabilize a 900 KDA presenilin complex: A tetrameric model for gamma-secretase. Neurobiology of Aging, 25, 558-558. <a href="http://dx.doi.org/10.1016/S0197-4580(04) 81850-5">[More Information]</a> Evin, G., Culvenor, J., Sernee, M., Hoke, D., Canterford, L., Holsinger, R., Cappai, R., Beyreuther, K., Masters, C. (2003). Gamma-secretase processing of APP transmembravpmne domain. 6th International Conference AD/PD, Seville, Spain: 6th International Conference AD/PD. Evin, G., Zhu, A., Holsinger, D., Masters, C., Li, Q. (2003). Proteolytic processing of the Alzheimer's Disease amyloid precursor protein in brain and platelets. Journal of Neuroscience Research, 74, 386-392. <a href="http://dx.doi.org/10.1002/jnr.10745">[Mor e Information]</a> Holsinger, R., Cullen, K., Culvenor, J., Roytta, K., Canterford, L., Masters, C., Evin, G. (2003). Redefinition of BACE1 transmembrane domain to include residues 455-460. International Conference on Aspartic Proteases and Inhibitors, Kyoto, Japan.: International Conference on Aspartic Proteases and Inhibitors. Holsinger, R., Cullen, K., Culvenor, J., Roytta, K., Masters, C., Evin, G. (2003). Redefinition of BACE1 transmembrane domain to include residues 455-460. 28th Lorne Conference on Protein Structure and Function, Victoria, Australia: 28th Lorne Conference on Protein Structure and Function. George, A., Holsinger, R., McLean, C., Laughton, K., Beyreuther, K., Evin, G., Masters, C., Li, Q. (2003). Regulation of APP processing in the Alzheimer’s transgenic mouse model with diet-induced hypercholesterolemia. Combio 2003 ASBMB, Melbourne, Australia: Combio 2003 ASBMB. 2002 Publications for Damian Holsinger Evin, G., Holsinger, R., Canterford, L., Hoke, D., Masters, C., Eggert, S., Weidemann, A., Beyreuther, K. (2002). APP C-terminal fragments in Alzheimer's disease brain. Neurobiology of Aging, 23(1), 656. Holsinger, R., McLean, C., Masters, C., Evin, G., Beyreuther, K. (2002). BACE and beta-secretase product CTF beta are increased in sporadic Alzheimer's disease brain. Neurobiology of Aging, 23(1), 663. Evin, G., Holsinger, R., Eggert, S., Weidmann, A., Canterford, L., Hoke, D., Gandy, S., McLean, C., Beyreuther, K., Masters, C. (2002). Carboxyl-terminal fragments of the amyloid precursor protein in Alzheimer’s disease brain: detection of γ-secretase products. Brain Aging International Journal, 29(3), 61-66. Holsinger, D., McLean, C., Beyreuther, K., Masters, C., Evin, G. (2002). Increased expression of the amyloid precursor beta secretase in Alzheimer's Disease. Annals of Neurology, 51(6), 783-786. <a href="http://dx.doi.org/10.1002/ana.10208">[Mo re Information]</a> Evin, G., Sernee, M., Barnham, K., Holsinger, R., Culvenor, J., Hoke, D., Li, Q., et al (2002). Modulation of Alzheimer's disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds. In K. Iqbal and B Winblad (Eds.), Alzheimer’s disease and related disorders: Research advances, (pp. 513-523). Bucharest, Romania: "Ana Alsan" International Academy of Aging. Fahnestock, M., Garzon, D., Holsinger, D., Michalski, B. (2002). Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule? Journal of Neural Transmission, 62(suppl.), 239-252. 2001 Evin, G., Sharples, R., Weidemann, A., Reinhard, F., Carbone, V., Culvenor, J., Holsinger, D., Sernee, M., Beyreuther, K., Masters, C. (2001). Aspartyl protease inhibitor pepstatin binds to the presenilins of Alzheimer's disease. Biochemistry, 62, 239-250. Holsinger, R., McLean, C., Beyreuther, K., Masters, C., Evin, G. (2001). Increased BACE Immunoreactivity in Alzheimer’s Disease Brain. Society for Neuroscience Abstract 2001, San Diego, USA: Society for Neuroscience Abstract 2001. 2000 Holsinger, R., Schnarr, J., Henry, P., Castelo, V., Fahnestock, M. (2000). Quantitation of BDNF mRNA in human parietal cortex by competitive reverse transcription-polymerase chain reaction: decreased levels in Alzheimer's disease. Molecular Brain Research, 76(2), 347-354. Holsinger, R., Cappai, R., McLean, C., Smith, M., Reinhard, F., Multhaup, G., Weidemann, A., Beyreuther, K., Masters, C., Evin, G. (2000). Quantitative analysis of BACE1 in normal and Alzheimer’s disease brain. Society for Neuroscience Abstract 2000, New Orleans USA: Society for Neuroscience Abstract 2000.