Publications for Trevor Hambley
Publications for Trevor Hambley
2016
Puranik, R., Bao, B., Bonin, A., Kaur, R., Weder,
J., Casbolt, L., Hambley, T., Lay, P., Barter, P.,
Rye, K. (2016). A novel class of copper(II)- and
zinc(II)-bound non-steroidal anti-inflammatory
drugs that inhibits acute inflammation in vivo.
Cell & Bioscience, 6(1), 1-7. <a
href="http://dx.doi.org/10.1186/s13578-016-007
6-8">[More Information]</a>
2015
Renfrew, A., Bryce, N., Hambley, T. (2015).
Cobalt(III) chaperone complexes of curcumin:
Photoreduction, cellular accumulation and
light-selective toxicity towards tumour cells.
Chemistry - A European Journal.
Shen, C., Harris, B., Dawson, L., Charles (nee
Slaviero), K., Hambley, T., New, E. (2015).
Fluorescent sensing of monofunctional platinum
species. Chemical Communications, 51(29),
6312-6314. <a
href="http://dx.doi.org/10.1039/c4cc08077g">[
More Information]</a>
Roberts, M., Pham, T., Doan, J., Jiang, C.,
Hambley, T., Greguric, I., Fraser, B. (2015).
Radiosynthesis and 'click' conjugation of
ethynyl-4-[18F]fluorobenze - an improved
[18F]synthon for indirect radiolabeling. Journal
of Labelled Compounds and
Radiopharmaceuticals, 58(13-14), 473-478. <a
href="http://dx.doi.org/10.1002/jlcr.3354">[Mor
e Information]</a>
2014
Eljack, N., Ma, H., Drucker, J., Shen, C.,
Hambley, T., New, E., Friedrich, T., Clarke, R.
(2014). Mechanisms of cell uptake and toxicity
of the anticancer drug cisplatin. Metallomics,
6(11), 2126-2133. <a
href="http://dx.doi.org/10.1039/c4mt00238e">[
More Information]</a>
Klein, A., Hambley, T. (2014). Platinum-Based
Anticancer Agents. In Tim Storr (Eds.), Ligand
Design in Medicinal Inorganic Chemistry, (pp.
9-45). Chichester, United Kingdom: John Wiley
& Sons.
2013
Renfrew, A., Bryce, N., Hambley, T. (2013).
Delivery and release of curcumin by a
hypoxia-activated cobalt chaperone: a XANES
and FLIM study. Chemical Science, 4(9),
3731-3739. <a
href="http://dx.doi.org/10.1039/c3sc51530c">[M
ore Information]</a>
Zhang, J., Bonnitcha, P., Wexselblatt, E., Klein,
A., Najajreh, Y., Gibson, D., Hambley, T.
(2013). Facile preparation of mono-, di- and
mixed-carboxylato platinum(IV) complexes for
versatile anticancer prodrug design. Chemistry: A
European Journal, 19(5), 1672-1676. <a
href="http://dx.doi.org/10.1002/chem.201203159
">[More Information]</a>
Chen, C., Zhang, J., Aitken, J., Hambley, T.
(2013). Influence of equatorial and axial
carboxylato ligands on the kinetic inertness of
platinum(IV) complexes in the presence of
ascorbate and cysteine and within DLD-1 cancer
cells. Journal of Medicinal Chemistry, 56(21),
8757-8764. <a
href="http://dx.doi.org/10.1021/jm401218n">[M
ore Information]</a>
Roberts, M., Pham, T., Doan, J., Fraser, B.,
Hambley, T., Greguric, I. (2013). Radiosynthesis
of [18F]-ethynyl-4-fluorobenzene for click
conjugation. Journal of Labelled Compounds
and Radiopharmaceuticals, 56(S1), P091-P091.
Bryce, N., Pham, B., Fong, N., Jain, N., Pan, E.,
Whan, R., Hambley, T., Hawkett, B. (2013). The
composition and end-group functionality of
sterically stabilized nanoparticles enhances the
effectiveness of co-administered cytotoxins.
Biomaterials Science, 1(12), 1260-1272. <a
href="http://dx.doi.org/10.1039/c3bm60120j">[
More Information]</a>
2012
Hawkett, B., Hambley, T., Bryce, N., Pham, B.,
Jain, N. (2012). A method for the treatment of a
solid tumour. Patent No. CA2833413 A1,
WO2012142669 A1. Canada.
Bonnitcha, P., Kim, B., Hocking, R., Clegg, J.,
Turner, P., Neville, S., Hambley, T. (2012).
Cobalt complexes with tripodal ligands:
Implications for the design of drug chaperones.
Dalton Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 41(37), 11293-11304. <a
href="http://dx.doi.org/10.1039/c2dt30727h">[M
ore Information]</a>
Yamamoto, N., Renfrew, A., Kim, B., Bryce, N.,
Hambley, T. (2012). Dual Targeting of Hypoxic
and Acidic Tumor Environments with a
Cobalt(III) Chaperone Complex. Journal of
Medicinal Chemistry, 55(24), 11013-11021. <a
href="http://dx.doi.org/10.1021/jm3014713">[M
ore Information]</a>
Yamamoto, N., Bryce, N., Metzler-Nolte, N.,
Hambley, T. (2012). Effects of enzymatic
activation on the distribution of fluorescently
tagged MMP-2 cleavable peptides in cancer cells
and spheroids. Bioconjugate Chemistry, 23(6),
1110-1118. <a
href="http://dx.doi.org/10.1021/bc200561n">[M
ore Information]</a>
Publications for Trevor Hambley
Zhang, J., Bryce, N., Lanzirotti, A., Chen, C.,
Paterson, D., De Jonge, M., Howard, D.,
Hambley, T. (2012). Getting to the core of
platinum drug bio-distributions: the penetration
of anti-cancer platinum complexes into spheroid
tumour models. Metallomics, 4(11), 1209-1217.
<a
href="http://dx.doi.org/10.1039/c2mt20168b">[
More Information]</a>
Zhang, J., Wexselblatt, E., Hambley, T., Gibson,
D. (2012). Pt(IV) analogs of oxaliplatin that do
not follow the expected correlation between
electrochemical reduction potential and rate of
reduction by ascorbate. Chemical
Communications, 48(6), 847-849. <a
href="http://dx.doi.org/10.1039/c1cc16647f">[M
ore Information]</a>
Hall, M., Daly, H., Zhang, J., Zhang, M.,
Alderden, R., Pursche, D., Foran, G., Hambley,
T. (2012). Quantitative measurement of the
reduction of platinum(IV) complexes using
X-ray absorption near-edge spectroscopy
(XANES). Metallomics, 4(6), 568-575. <a
href="http://dx.doi.org/10.1039/c2mt20053h">[
More Information]</a>
Failes, T., Battle, A., Chen, C., Cullinane, C.,
Woods, R., Elliott, R., Deacon, G., Hambley, T.
(2012). Structural and anticancer properties of
hydrogen bonded diphenyl phosphate adducts of
Pt(IV) complexes: The importance of pKa
matching. Journal of Inorganic Biochemistry,
115, 220-225. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2012.
04.010">[More Information]</a>
Guo, S., Mason, D., Turland, S., Lawrenz, E.,
Kelly, L., Fallon, G., Gatehouse, B., Bond, A.,
Deacon, G., Battle, A., Hambley, T., et al (2012).
Systematic differences in electrochemical
reduction of the structurally characterized
anti-cancer platinum(IV) complexes
[Pt((p-HC6F4)NCH2)2-(pyridine)2Cl2],
[Pt((p-HC6F4)NCH2)2(pyridine)2(OH)2], and
[Pt((p-HC6F4)NCH2)2(pyridine)2(OH)Cl].
Journal of Inorganic Biochemistry, 115(2012),
226-239. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2012.
07.016">[More Information]</a>
Zhang, J., Bryce, N., Siegele, R., Carter, E.,
Paterson, D., De Jonge, M., Howard, D., Ryan,
C., Hambley, T. (2012). The use of spectroscopic
imaging and mapping techniques in the
characterisation and study of
Wolf, S., Huynh, T., Bryce, N., Hambley, T.,
Wakelin, L., Stewart, B., Catchpoole, D. (2011).
Intracellular trafficking as a determinant of
AS-DACA cytotoxicity in rhabdomyosarcoma
cells. BMC Cell Biology, 12(36), 1-11. <a
href="http://dx.doi.org/10.1186/1471-2121-12-3
6">[More Information]</a>
Yadav, P., Beveridge, R., Blay, J., Boyd, A.,
Chojnacka, M., Decken, A., Deshpande, A.,
Gardiner, M., Hambley, T., Hughes, M., New,
E., et al (2011). Platinum-oxazoline complexes
as anti-cancer agents: syntheses, characterisation
and initial biological studies. MedChemComm
(Medicinal Chemistry Communications), 2(4),
274-277. <a
href="http://dx.doi.org/10.1039/c0md00211a">[
More Information]</a>
Daly, H., Hall, M., Failes, T., Zhang, M., Foran,
G., Hambley, T. (2011). Stabilization of
Triam(m)inechloridoplatinum Complexes by
Oxidation to Pt(IV). Australian Journal of
Chemistry, 64(3), 273-278. <a
href="http://dx.doi.org/10.1071/CH11041">[Mor
e Information]</a>
Norman, J., Hambley, T. (2011). Targeting
strategies for metal-based therapeutics. In
Professor Enzo Alessio (Eds.), Bioinorganic
Medicinal Chemistry, (pp. 49-78). Germany:
Wiley - V C H Verlag GmbH & Co. KGaA.
Cubo, L., Hambley, T., Sanz Miguel, P.,
Carnero, A., Navarro-Ranninger, C., Quiroga, A.
(2011). The preparation and characterization of
trans-platinum(IV) complexes with unusually
high cytotoxicity. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry,
40(2), 344-347. <a
href="http://dx.doi.org/10.1039/c0dt00565g">[M
ore Information]</a>
Kim, B., Hambley, T., Bryce, N. (2011).
Visualising the hypoxia selectivity of cobalt(III)
prodrugs. Chemical Science, 2(11), 2135-2142.
<a
href="http://dx.doi.org/10.1039/c1sc00337b">[
More Information]</a>
2010
DLD-1 cell spheroid tumour models. Integrative
Biology, 4(9), 1072-1080. <a
href="http://dx.doi.org/10.1039/c2ib20121f">[M
ore Information]</a>
Ma, Y., Bryce, N., Whan, R., Xiao, L., Li, K.,
Ruys, A., Hambley, T., Boughton, P. (2010).
Growth of DLD-1 Colon Cancer Cells on
VariotisTM Scaffolds of Controlled Porosity: A
Preliminary Study. Journal of Biomimetics,
Biomaterials, and Tissue Engineering, 8, 79-89.
<a
href="http://dx.doi.org/10.4028/www.scientific.n
et/JBBTE.8.79">[More Information]</a>
2011
Bonin, A., Yanez, J., Fukuda, C., Teng, X.,
Dillon, C., Hambley, T., Lay, P., Davies, N.
Publications for Trevor Hambley
(2010). Inhibition of experimental colorectal
cancer and reduction in renal and gastrointestinal
toxicities by copper-indomethacin in rats. Cancer
Chemotherapy and Pharmacology, 66(4),
755-764. <a
href="http://dx.doi.org/10.1007/s00280-009-122
0-5">[More Information]</a>
3(S)-aminohexahydroazepine) bound to a DNA
14-mer oligonucleotide. NMR evidence of
structural alteration of a platinated A.T-rich
14-mer DNA duplex. Inorganic Chemistry,
48(7), 3047-3056. <a
href="http://dx.doi.org/10.1021/ic802207m">[M
ore Information]</a>
Battle, A., Bond, A., Chow, A., Daniels, D.,
Deacon, G., Hambley, T., Junk, P., Mason, D.,
Wang, J. (2010). Syntheses and structures of
N-polyfluorophenyl- and
N,N'-bis(polyfluorophenyl)ethane-1,2-diaminato(
1- or 2-)platinum(II) complexes. Journal of
Fluorine Chemistry, 131(11), 1229-1236. <a
href="http://dx.doi.org/10.1016/j.jfluchem.2010.
05.011">[More Information]</a>
Hambley, T. (2009). Improving anticancer drug
penetration in solid tumours (Invited lecture).
14th International Conference on Biological
Inorganic Chemistry, N/A: N/A.
2009
Bryce, N., Zhang, J., Whan, R., Yamamoto, N.,
Hambley, T. (2009). Accumulation of an
anthraquinone and its platinum complexes in
cancer cell spheroids: The effect of charge on
drug distribution in solid tumour models.
Chemical Communications, 2009 (19),
2673-2675. <a
href="http://dx.doi.org/10.1039/b902415h">[Mo
re Information]</a>
Whan, R., Messerle, B., Hambley, T. (2009).
Binding of [Pt(1C3)(dien)]2+ to the duplex DNA
oligonucleotide 5'-d(TGGCCA)-3': The effect of
an appended positive charge on the orientation
and location of anthraquinone intercalation.
Dalton Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 2009 (6), 932-939. <a
href="http://dx.doi.org/10.1039/b814604g">[Mo
re Information]</a>
Er, H., Hambley, T. (2009). Enantioselectivity
and stereoselectivity in the reactions of the
enantiomers of the platinum complex
[PtCl(2)(ahaz)] (ahaz = 3(R)- or
3(S)-aminohexahydroazepine) with DNA.
Journal of Inorganic Biochemistry, 103(2),
168-173. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2008.
09.016">[More Information]</a>
New, E., Roche, C., Madawala, R., Zhang, J.,
Hambley, T. (2009). Fluorescent analogues of
quinoline reveal amine ligand loss from cis and
trans platinum(II) complexes in cancer cells.
Journal of Inorganic Biochemistry, 103(8),
1120-1125. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2009.
05.005">[More Information]</a>
Diakos, C., Messerle, B., Murdoch, P.,
Parkinson, J., Sadler, P., Fenton, R., Hambley, T.
(2009). Identification by NMR spectroscopy of
the two steroisomers of the platinum complex
[PtCl2(S-ahaz)] (S-ahaz =
Hambley, T., Gui, X. (2009). Investigations into
the electrochemical properties of Pt(IV) agents.
14th International Conference on Bioinorganic
Chemistry.
New, E., Duan, R., Zhang, J., Hambley, T.
(2009). Investigations using fluorescent ligands
to monitor platinum(IV) reduction and
platinum(II) reactions in cancer cells. Dalton
Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 2009 (16), 3092-3101. <a
href="http://dx.doi.org/10.1039/b821603g">[Mo
re Information]</a>
Clarke, A., Yamamoto, N., Jensen, P., Hambley,
T. (2009). Iron(III) complexes of fluorescent
hydroxamate ligands: preparation, properties,
and cellular processing. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry,
2009 (48), 10787-10798. <a
href="http://dx.doi.org/10.1039/b914368h">[Mo
re Information]</a>
Hambley, T. (2009). Is anticancer drug
development heading in the right direction?
Cancer Research, 69(4), 1259-1262. <a
href="http://dx.doi.org/10.1158/0008-5472.CAN
-08-3786">[More Information]</a>
Comba, P., Hambley, T., Martin, B. (2009).
Molecular Modeling of Inorganic Compounds:
Third, Completely Revised and Enlarged Edition.
Federal Republic of Germany: Wiley - V C H
Verlag GmbH & Co. KGaA.
Zhang, J., Whan, R., Hambley, T. (2009).
Platinum anticancer drugs, chemical biology of.
In Natanya Civjan (Eds.), Wiley Encyclopaedia
of Chemical Biology, (pp. 721-730). Hoboken,
New Jersey, USA: John Wiley & Sons.
Klein, A., Hambley, T. (2009). Platinum drug
distribution in cancer cells and tumors. Chemical
Reviews, 109(10), 4911-4920. <a
href="http://dx.doi.org/10.1021/cr9001066">[M
ore Information]</a>
Diakos, C., Zhang, M., Beale, P., Fenton, R.,
Hambley, T. (2009). Synthesis, characterisation
and in vitro cytotoxicity studies of a series of
chiral platinum(II) complexes based on the
Publications for Trevor Hambley
2-aminomethylpyrrolidine ligand: X-ray crystal
structure of [PtC12(R-dimepyrr)] (R-dimepyrr =
N-dimethyl-2(R)-aminomethylpyrrolidine).
European Journal of Medicinal Chemistry,
44(7), 2807-2814. <a
href="http://dx.doi.org/10.1016/j.ejmech.2008.12
.022">[More Information]</a>
Hambley, T. (2009). Targeted cancer
therapeutics response. Cancer Research, 69(4),
1267-1267.
Zhang, J., Bryce, N., Hambley, T. (2009). The
penetration and accumulation of anti-tumour
platinum(II) complexes in spheroid tumour
models. 14th International Conference on
Biological Inorganic Chemistry, N/A: N/A.
Bryce, N., Zhang, J., Hambley, T. (2009).
Visualising drug diffusion in a 3-dimensional
tumour spheroid model system. 100th Annual
Meeting of the American Association for Cancer
Research, USA: N/A.
Yamamoto, N., Bryce, N., Danos, S., Hambley,
T. (2009). Visualising the uptake of fluorescently
tagged cobalt chaperones in solid tumour
models. 14th International Conference on
Biological Inorganic Chemistry, N/A: N/A.
2008
Davies, M., Hall, M., Berners-Price, S.,
Hambley, T. (2008). [(1)H, (15)N] Heteronuclear
Single Quantum Coherence NMR Study of the
Mechanism of Aquation of Platinum(IV)
Ammine Complexes. Inorganic Chemistry,
47(17), 7673-7680. <a
href="http://dx.doi.org/10.1021/ic8006734">[Mo
re Information]</a>
Yamamoto, N., Danos, S., Bonnitcha, P., Failes,
T., New, E., Hambley, T. (2008). Cellular uptake
and distribution of cobalt complexes of
fluorescent ligands. Journal of Biological
Inorganic Chemistry, 13(6), 861-871. <a
href="http://dx.doi.org/10.1007/s00775-008-037
4-7">[More Information]</a>
Hambley, T. (2008). Physiological Targeting to
Improve Anticancer Drug Selectivity. Australian
Journal of Chemistry, 61(9), 647-653. <a
href="http://dx.doi.org/10.1071/CH08180">[Mor
e Information]</a>
Guenther, K., Hambley, T., Kassiou, M. (2008).
Radiolabelled probes for imaging multidrug
resistance using single photon emission
tomography (SPECT) and positron emission
tomography (PET). In Nicola Antonio Colabufo
(Eds.), Multidrug Resistance: Biological and
Pharmaceutical Advances in Antitumour
Treatment, (pp. 291-320). India: Research
Signpost.
2007
Hall, M., Mellor, H., Callaghan, R., Hambley, T.
(2007). Basis for design and development of
platinum(IV) anticancer complexes. Journal of
Medicinal Chemistry, 50(15), 3403-3411.
Hall, M., Failes, T., Yamamoto, N., Hambley, T.
(2007). Bioreductive activation and drug
chaperoning in cobalt pharmaceuticals. Dalton
Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, (36), 3983-3990.
Hocking, R., Hambley, T. (2007). Database
analysis of transition metal carbonyl bond
lengths: Insight into the periodicity of pi
back-bonding, sigma donation, and the factors
affecting the electronic structure of the TM-C=O
moiety. Organometallics, 26(11), 2815-2823.
Hambley, T. (2007). Developing new
metal-based therapeutics: Challenges and
opportunities. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry,
2007 (43), 4929-4937.
Hocking, R., Deeth, R., Hambley, T. (2007).
DFT study of the systematic variations in
metal-ligand bond lengths of coordination
complexes: The crucial role of the condensed
phase. Inorganic Chemistry, 46(20), 8238-8244.
Alderden, R., Mellor, H., Modok, S., Hall, M.,
Sutton, S., Newville, M., Callaghan, R.,
Hambley, T. (2007). Elemental tomography of
cancer-cell spheroids reveals incomplete uptake
of both platinum(II) and platinum(IV)
complexes. Journal of the American Chemical
Society, 129(44), 13400-13401.
Hambley, T. (2007). Metal-based therapeutics.
Science, 318(5855), 1392-1393.
Failes, T., Cullinane, C., Diakos, C., Yamamoto,
N., Lyons, J., Hambley, T. (2007). Studies of a
Cobalt(III) complex of the MMP inhibitor
marimastat: A potential hypoxia-activated
prodrug. Chemistry: A European Journal,
13(10), 2974-2982. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=17171733">[More Information]</a>
Failes, T., Hambley, T. (2007). Towards
bioreductively activated prodrugs: Fe(III)
complexes of hydroxamic acids and the MMP
inhibitor marimastat. Journal of Inorganic
Biochemistry, 101, 396-403. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2006.
11.003">[More Information]</a>
Modok, S., Scott, R., Alderden, R., Hall, M.,
Mellor, H., Bohic, S., Roose, T., Hambley, T.,
Callaghan, R. (2007). Transport kinetics of fourand six-coordinate platinum compounds in the
multicell layer tumour model. British Journal of
Publications for Trevor Hambley
Cancer, 97(2), 194-200.
Hall, M., Underwood, C., Failes, T., Foran, G.,
Hambley, T. (2007). Using XANES to monitor
the oxidation state of cobalt complexes.
Australian Journal of Chemistry, 60(3), 180-183.
2006
Alderden, R., Mellor, H., Modok, S., Hambley,
T., Callaghan, R. (2006). Cytotoxic efficacy of
an anthraquinone linked platinum anticancer
drug. Biochemical Pharmacology, 71(8),
1136-1145. <a
href="http://dx.doi.org/10.1016/j.bcp.2005.12.03
9">[More Information]</a>
Diakos, C., Fenton, R., Hambley, T. (2006).
DNA-binding and molecular mechanics
modelling studies of the bulky chiral platinum(II)
complex [PtCl2(mepyrr)] (mepyrr =
N-methyl-2-aminomethylpyrrolidine). Journal of
Inorganic Biochemistry, 100(12), 1965-1973. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2006.
09.012">[More Information]</a>
Costa, L., Hambley, T., Rocha, W., De Almeida,
W., Dos Santos, H. (2006). Kinetics and
structural aspects of the cisplatin interactions
with guanine: A quantum mechanical
description. International Journal of Quantum
Chemistry, 106(9), 2129-2144. <a
href="http://dx.doi.org/10.1002/qua.20979">[Mo
re Information]</a>
Failes, T., Hambley, T. (2006). Models of
hypoxia activated prodrugs: Co(III) complexes
of hydroxamic acids. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry,
2006 (15), 1895-1901.
Battle, A., Choi, R., Hibbs, D., Hambley, T.
(2006). Platinum(IV) analogues of AMD473
(cis-[PtCl2(NH3)(2-picoline)]): preparative,
structural, and electrochemical studies. Inorganic
Chemistry, 45(16), 6317-6322. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16878941">[More Information]</a>
Alderden, R., Hall, M., Hambley, T. (2006). The
discovery and development of cisplatin. Journal
of Chemical Education, 83(5), 728-734.
Hall, M., Alderden, R., Zhang, M., Beale, P.,
Cai, Z., Lai, B., Stampfl, A., Hambley, T. (2006).
The fate of platinum(II) and platinum(IV)
anti-cancer agents in cancer cells and tumours.
Journal of Structural Biology, 155(1), 38-44. <a
href="http://www.ncbi.nlm.nih.gov/entrez/query.
fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract
&list_uids=16630726">[More Information]</a>
Bonnitcha, P., Hall, M., Underwood, C., Foran,
G., Zhang, M., Beale, P., Hambley, T. (2006).
XANES investigation of the Co oxidation state
in solution and in cancer cells treated with
Co(III) complexes. Journal of Inorganic
Biochemistry, 100(5-6), 963-971. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2006.
02.015">[More Information]</a>
2005
Malina, J., Voitiskova, M., Brabec, V., Diakos,
C., Hambley, T. (2005). DNA adducts of the
enantiomers of the Pt(II) complexes of the ahaz
ligand (ahaz=3-aminohexahydroazepine) and
recognition of these adducts by HMG domain
proteins. Biochemical and Biophysical Research
Communications, 332(4), 1034-1041. <a
href="http://dx.doi.org/10.1016/j.bbrc.2005.05.0
47">[More Information]</a>
Ramadan, S., Bonin, A., Kennedy, B., Hambley,
T., Lay, P. (2005). Nuclear magnetic resonance
analysis of indomethacin-induced gastric ulcers.
Chemical Research in Toxicology, 18(2),
123-128.
Hocking, R., Hambley, T. (2005). Structural
measures of element-oxygen bond covalency
from the changes to the delocalisation of the
carboxylate ligand. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry,
2005 (5), 969-978.
Mellor, H., Hall, M., Hambley, T., Snelling, S.,
Modok, S., Jaffar, M., Callaghan, R. (2005). The
influence of tumour microenvironmental factors
on the efficacy of cisplatin and novel
platinum(IV) complexes. Biochemical
Pharmacology, 70(8), 1137-1146. <a
href="http://dx.doi.org/10.1016/j.bcp.2005.07.01
6">[More Information]</a>
2004
Hall, M., Martin, C., Ferguson, D., Phillips, R.,
Hambley, T., Callaghan, R. (2004). Comparative
Efficacy Of Novel Platinum(IV) Compounds
With Established Chemotherapeutic Drugs In
Solid Tumour Models. Biochemical
Pharmacology, 67(1), 17-30. <a
href="http://dx.doi.org/10.1016/j.bcp.2003.07.01
6">[More Information]</a>
Dillon, C., Hambley, T., Kennedy, B., Lay, P.,
Weder, J., Zhou, Q. (2004). Copper And Zinc
Complexes As Antiinflammatory Drugs. In
Astrid Sigel & Helmut Sigel (Eds.), Metal Ions
in Biological Systems : Volume 41 : Metal Ions
and their Complexes in Medication, (pp.
253-277). New York: Marcel Dekker.
Ramadan, S., Hambley, T., Kennedy, B., Lay, P.
(2004). Nmr Spectroscopic Characterization Of
Copper(Ii) And Zinc(Ii) Complexes Of
Indomethacin. Inorganic Chemistry, 43(9),
2943-2946.
Publications for Trevor Hambley
Rendina, L., Hambley, T. (2004). Platinum. In
D. E. Fenton (Eds.), Comprehensive
Coordination Chemistry II : From biology to
nanotechnology. Volume 6: Transition Metal
groups 9-12, (pp. 673-745). Amsterdam:
Elsevier.
Hall, M., Dolman, R., Hambley, T. (2004).
Platinum(Iv) Anticancer Complexes. In Astrid
Sigel & Helmut Sigel (Eds.), Metal Ions in
Biological Systems: Volume 42. Metal
Complexes in Tumor Diagnosis and as
Anticancer Agents, (pp. 297-322). New York:
Marcel Dekker.
Allan, R., Greenwood, J., Hambley, T.,
Hanrahan, J., Hibbs, D., Itani, S., Tran, H.,
Turner, P. (2004). Studies On Pyridazine Azide
Cyclisation Reactions. Organic and
Biomolecular Chemistry, 2(12), 1782-8-1788.
Hall, M., Amjadi, S., Zhang, M., Beale, P.,
Hambley, T. (2004). The mechanism of action of
platinum(IV) complexes in ovarian cancer cell
lines. Journal of Inorganic Biochemistry, 98,
1614-1624. <a
href="http://dx.doi.org/10.1016/j.jinorgbio.2004.
05.017">[More Information]</a>
Levina, A., Codd, R., Foran, G., Hambley, T.,
Maschmeyer, T., Masters, A., Lay, P. (2004).
X-Ray Absorption Spectroscopic Studies Of
Chromium(V/Iv/Iii)2-Ethyl-2-Hydroxybutanoato
(2-/1-) Complexes. Inorganic Chemistry, 43(3),
1046-1055.
2003
Failes, T., Diakos, C., Underwood, C., Hambley,
T., Cullinane, C., Lyons, G. (2003). Can metal
complexes serve as hypoxia activated prodrugs?
Investigations of a Co(III) complex of the MMP
inhibitor marimastat. Journal of Inorganic
Biochemistry, 96(1), 128.
Field, L., Messerle, B., Rehr, M., Soler, L.,
Hambley, T. (2003). Cationic iridium(I)
complexes as catalysts for the alcoholysis of
silanes. Organometallics, 22(12), 2387-2395.
Hall, M., Hambley, T., Beale, P., Zhang, M.,
Dillon, C., Foran, G., Stampfl, A., Lai, B. (2003).
Does platinum(IV) survive in tumour cells?
Journal of Inorganic Biochemistry, 96(1), 141.
Waller, M., Hibbs, D., Overgaard, J., Hanrahan,
J., Hambley, T. (2003). Flavone. Acta
Crystallographica. Section E: Structure Reports
Online, 59(6), o767-o768.
Dillon, C., Hambley, T., Kennedy, B., Lay, P.,
Zhou, Q., Davies, N., Biffen, R., Regtop, H.
(2003). Gastrointestinal Toxicity,
Antiinflammatory Activity, and Superoxide
Dismutase Activity of Copper and Zinc
Complexes of the Antiinflammatory Drug
Indomethacin. Chemical Research in Toxicology,
16(1), 28-37.
Alderden, R., Hall, M., Amjadi, S., Hambley, T.,
Beale, P., Zhang, M., Lai, M., Stampfl, A.
(2003). Increasing the cellular accumulation of
platinum(IV) complexes. Journal of Inorganic
Biochemistry, 96(1), 89.
Failes, T., Hambley, T. (2003). Insights into
Pt(II)-hydroxamate bonding through the crystal
structures of DMSO complexes. Australian
Journal of Chemistry, 56(1), 45-48.
Bulluss, G., Waller, M., Hambley, T. (2003).
Investigation of rotamers about the Pt-N7 bonds
in bulky [Pt(d(GpG))(diamine)] complexes.
Journal of Inorganic Biochemistry, 96(1), 108.
Munk, V., Diakos, C., Ellis, L., Fenton, R.,
Hambley, T., Messerle, B. (2003). Investigations
into the interactions between DNA and
conformationally constrained
pyridylamineplatinum(II) analogues of
AMD473. Inorganic Chemistry, 42(11),
3582-3590.
Bernhardt, P., Hambley, T., Lawrance, G.,
Maeder, M., Wilkes, E. (2003). Isomers of
1,4,8,11-tetraazacyclotetradecane-6,13-dicarboxy
late characterized as cobalt(III) complexes.
Australian Journal of Chemistry, 56(7), 679-684.
Bulluss, G., Waller, M., Hambley, T. (2003).
Mechanism of action of platinum complex
binding to DNA. Journal of Inorganic
Biochemistry, 96(1), 109.
Brown, K., Geue, R., Hambley, T., Hockless, D.,
Rae, A., Sargeson, A. (2003). Specificity in
template syntheses of hexaaza-macrobicyclic
cages: [Pt(Me5-tricosatrieneN6)]4+ and
[Pt(Me5-tricosaneN6)]4+. Organic and
Biomolecular Chemistry, 1, 1598-1608.
Hocking, R., Hambley, T. (2003). Structural
insights into transition-metal carbonyl bonding.
Chemical Communications, 2003 (13),
1516-1517.
Hocking, R., Hambley, T. (2003). Structural
measure of metal-ligand covalency from the
bonding in carboxylate ligands. Inorganic
Chemistry, 42(9), 2833-2835.
Hall, M., Dillon, C., Zhang, M., Beale, P., Cai,
Z., Lai, B., Stampfl, A., Hambley, T. (2003). The
cellular distribution and oxidation state of
platinum(II) and platinum(IV) antitumour
complexes in cancer cells. Journal of Biological
Inorganic Chemistry, 8(7), 726-732. <a
href="http://dx.doi.org/10.1007/s00775-003-047
1-6">[More Information]</a>
Hibbs, D., Overgaard, J., Hambley, T., Gatti, C.
(2003). The electron density in flavones I.
Baicalein. New Journal of Chemistry, 27(9),
Publications for Trevor Hambley
1392-1398.
Failes, T., Hall, M., Hambley, T. (2003). The
first examples of platinum amine hydroxamate
complexes: structures and biological activity.
Dalton Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 2003 (8), 1596-1600.
Underwood, C., Min, D., Lyons, G., Hambley, T.
(2003). The interaction of metal ions and
Marimastat with matrix metalloproteinase 9.
Journal of Inorganic Biochemistry, 95(2-3),
165-170.
Ellis, L., Perkins, D., Turner, P., Hambley, T.
(2003). The preparation and charcterisation of
cyclam/anthraquinone macrocyle/intercalator
complexes and their interactions with DNA.
Dalton Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 2003 (13), 2728-2736.
Giannikopoulos, G., Teo, C., Hall, M., Fenton,
R., Hambley, T. (2003). The synthesis and in
vitro cytotoxicity of two trans-platinum
complexes of heterocyclic amines. Australian
Journal of Chemistry, 56(7), 685-689.
Zhou, Q., Hambley, T., Kennedy, B., Lay, P.
(2003). XAFS studies of anti-inflammatory
dinuclear and mononuclear Zn(II) complexes of
indomethacin. Inorganic Chemistry, 42(25),
8557-8566.
Hall, M., Foran, G., Zhang, M., Beale, P.,
Hambley, T. (2003). XANES determination of
the platinum oxidation state distribution in
cancer cells treated with platinum(IV) anticancer
agents. Journal of the American Chemical
Society, 125(25), 7524-7525.
2002
Hotze, A., Chen, Y., Hambley, T., Parsons, S.,
Kratochwil, N., Parkinson, J., Munk, V., Sadler,
P. (2002).
Cis-[PtCl2(NH3)2-(2-hydroxyethyl)pyridine] an Analogue of the Anticancer Drug AMD473:
Unusual Hydrolysis Rates and pKa Values for
the Diaqua Adduct. European Journal of
Inorganic Chemistry, 2002 (5), 1035-1039.
Weder, J., Dillon, C., Hambley, T., Kennedy, B.,
Lay, P., Biffin, J., Regtop, H., Davies, N. (2002).
Copper complexes of non-steroidal
anti-inflammatory drugs: an opportunity yet to be
realized. Coordination Chemistry Reviews,
232(1-2), 95-126.
Battle, A., Deacon, G., Dolman, R., Hambley, T.
(2002). Electrochemistry, Protein Binding and
Crystal Structures of Platinum(II) and
Platinum(IV) Carboxylato Complexes.
Australian Journal of Chemistry, 55(11),
699-704.
Davies, M., Wong, P., Battle, A., Haddad, G.,
McKeage, M., Hambley, T. (2002). Examination
of the effects of oxidation and ring closure on the
cytotoxicities of the platinum complexes of
N-(2-hydroxyethyl)ethane-1,2-diamine and
ethane-1,2-diamine-N,N9-diacetic acid. Journal
of Inorganic Biochemistry, 91(1), 205-211.
Hambley, T., Hibbs, D., Turner, P., Howard, S.,
Hursthouse, M. (2002). Insights into bonding and
hydrogen bond directionality in thioacetamide
from the experimental charge distribution.
Journal of the Chemical Society Perkin
Transactions 2, 2(2002), 235-239.
Munk, V., Cham, S., Fenton, R., Hocking, R.,
Hambley, T. (2002). Insights into the van der
Waals Radius of Low-Spin Ni(II) from
Molecular Mechanics Studies and the Crystal
Structures of
[Ni(cis-cyclohexane-1,3-diamine)2]Cl2,
[Ni(R)-5,5,7-trimethyl-1,4-diazacycloheptane2]C
l2.H2O and
[Ni(5,7-dimethyl-1,4-diazacyclohept. Australian
Journal of Chemistry, 55(8), 523-529.
Field, L., Messerle, B., Soler, L., Hambley, T.,
Turner, P. (2002). Iron(II) complexes containing
poly(1-pyrazolyl)methane ligands. Journal of
Organometallic Chemistry, 655(1-2), 146-157.
Greguric, A., Greguric, I., Hambley, T.,
Aldrich-Wright, J., Collins, J. (2002). Minor
groove intercalation of
Delta-[Ru(Me2phen)2dppz]2+ to the
hexanucleotide d(GTCGAC)2. Dalton
Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 10, 849-855.
Hall, M., Hambley, T. (2002). Platinum(IV)
antitumour compounds: their bioinorganic
chemistry. Coordination Chemistry Reviews,
232(1-2), 49-67.
Cullinane, C., Deacon, G., Drago, P., Hambley,
T., Nelson, K., Webster, L. (2002). Preparation
and cell growth inhibitory activity of [PtR2L2]
(R=polyfluorophenyl, L2 = diene,
cyclohexane-1,2-diamine (chxn) or cis-(dimethyl
sulfoxide)2) and the X-ray crystal structure of
[Pt(C6F5)2(cis-chxn)]. Journal of Inorganic
Biochemistry, , 293-301.
Hocking, R., Hambley, T. (2002). Statistical and
Molecular Mechanics Analysis of the Effects of
Changing Donor Type on Bond Length in the
Two Series [CoIIINnO6-n] and [NiIINnO6-n] (n
= 0-6): A New Route to Bond-Stretch
Parameters. Inorganic Chemistry, 41(10),
2660-2666.
Munk, V., Diakos, C., Messerle, B., Fenton, R.,
Hambley, T. (2002). Stereospecificity and
Enantioselectivity in the Binding of the
Publications for Trevor Hambley
Platinum(II) Complex [PtCl2(tmdz)]
(tmdz=5,5,7-Trimethyl-1,4-diazacycloheptane)
to
Dinucleotides and Oligonucleotides. Chemistry:
A European Journal, 8(23), 5486-5493.
Hall, M., Failes, T., Hibbs, D., Hambley, T.
(2002). Structural Investigations of Palladium(II)
and Platinum(II) Complexes of
Salicylhydroxamic Acid. Inorganic Chemistry,
41(5), 1223-1228.
Dolman, R., Deacon, G., Hambley, T. (2002).
Studies of the binding of a series of platinum(IV)
complexes to plasma proteins. Journal of
Inorganic Biochemistry, 88(3-4), 260-267.
Wei, G., Hambley, T., Lawrance, G., Maeder, M.
(2002). Synthesis and Complexation of a Chiral
Sexidentate Pendant-Arm Macropolycyclic
Polyamino Acid. Australian Journal of
Chemistry, 55(10), 667-673.
Battle, A., Platts, J., Hambley, T., Deacon, G.
(2002). Synthesis, spectroscopy, and theoretical
studies of platinum(II) phosphate complexes.
Dalton Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, , 1898-1902.
Aldrich-Wright, J., Fenton, R., Greguric, A.,
Hambley, T., Williams, P. (2002). The
stereospecific synthesis of
lambda-alpha-dipyrido[3,2-a:2'3'-c]-(6,7,8,9-tetra
hydro)phenazine[N,N'-di(2-picolyl)-2,5-dimethyl
-2S,5S-diaminocyclohexane]ruthenium(II) and
related beta-isomers. Dalton Transactions: an
international journal of inorganic,
organometallic and bioinorganic chemistry, 24,
4666-4671.
Hambley, T., Katsifis, A., Knott, R., Mattner,, F.,
Dikic, B. (2002). The Structures of Imidazenil
and Iodoimidazenil. Australian Journal of
Chemistry, 55(11), 737-739.
Field, L., Hambley, T., Humphrey, P., Masters,
A., Turner, P. (2002). X-ray Crystal Structure of
(eta5-Pentaphenylcyclopentadienyl)1-(eta5/6-phe
nyl)-2,3,4,5-tetraphenylcyclopentadienyliron(II),
[Fe(eta5-C5Ph5)eta5/6-C6H5)C5Ph4], a Linkage
Isomer of Decaphenylferrocene. Inorganic
Chemistry, 41(18), 4618-4620.
2001
Hambley, T., Turner, P., Jackson, T., Kojima,,
M., Knott,, R., Lambrecht,, R. (2001).
6,6,9,9-tetramethyl-1,2,5,6,9,9a-hexahydro-imida
zo[2,1-d][1,2,5]dithiazepin-1-ium triiodide. Acta
Crystallographica. Section E: Structure Reports
Online, E57, 315-317.
Hall, B., Hanrahan, J., Johnston, G., Hambley,
T., Hibbs, D. (2001). 6-Methylflavone. Acta
Crystallographica. Section E: Structure Reports
Online, E57.
Platts, J., Hibbs, D., Hambley, T., Hall, M.
(2001). Calculation of the hydrophobicity of
platinum drugs. Journal of Medicinal Chemistry,
44(3), 472-474.
Weder, J., Hambley, T., Kennedy, B., Lay, P.,
Rich, A., Foran, G. (2001). Determination of the
structures of antiinflammatory copper(II) dimers
of indomethacin by multiple-scattering analyses
of X-ray absorption fine structure data. Inorganic
Chemistry, 40, 1295-1302.
Headlam, H., Weeks, C., Turner, P., Hambley,
T., Lay, P. (2001). Dinuclear chromium(V)
amino acid complexes from the reduction of
chromium(VI) in the presence of amino acid
ligands: XAFS characterization of a
chromium(V) amino acid complex. Inorganic
Chemistry, 40, 5097-5105.
Cham, S., Diakos, C., Ellis, L., Fenton, R.,
Munk, V., Hambley, T., Messerle, B. (2001).
Isomer formation in the binding of
[PtCl2(cis-cyclohexane-1,3-diamine)] to
oligonucleotides and the X-ray crystal structure
of
[PtCl2(cis-cyclohexane-1,3-diamine)].dimethylfo
rmamide. Dalton Transactions: an international
journal of inorganic, organometallic and
bioinorganic chemistry, 2001, 2769-2774.
Hambley, T., Lindoy, L., Reimers, J., Turner, P.,
Wei, G., Widmer-Cooper, A. (2001).
Macrocyclic ligand design. X-ray, DFT and
solution studies of the effect of N-methylation
and N-benzylation of
1,4,10,13-tetraoxa-7,16-diazacyclooctadecane on
its affinity for selected transition and
post-transition metal ions. Dalton Transactions:
an international journal of inorganic,
organometallic and bioinorganic chemistry,
2001, 614-620.
Hambley, T., Bonin, A., Davies, N., Dillon, C.,
Weder, J., Kennedy, B., Lay, P., Morgan, Y.,
Zhou, Q., Biffin, J., et al (2001). Metal
complexes of non-steroidal anti-inflammatory
drugs: An opportunity yet to be realised. 10th
International Conference on Bioinorganic
Chemistry, : Ads & Adea.
Dillon, C., Davies, N., Hambley, T., Kennedy,
B., Lay, P., Zhou, Q., Stampfl, A., Cai, Z., Lai,
B., Biffin, J., et al (2001). Micro-SRIXE and
micro-XANES analysis of carcinogens and
anti-inflammatory drugs in mammalian cells.
10th International Conference on Bioinorganic
Chemistry, : Ads & Adea.
Hambley, T., Jones, A. (2001). Molecular
mechanics modelling of Pt/nucleotide and
Pt/DNA interactions. Coordination Chemistry
Reviews, 212, 35-59.
Publications for Trevor Hambley
Hambley, T., Comba, P. (2001). Molecular
Modeling of Inorganic Compounds. Germany:
Wiley - V C H Verlag GmbH & Co. KGaA.
Wong, P., Davies, M., Hambley, T. (2001).
Oxidation of
[PtIICl2(ethane-1,2-diamine-N,N'dicarboxylic
Acid)] and Ligand Ring Closure in the
Platinum(IV) Oxidation State. Australian
Journal of Chemistry, 54, 303-306.
Hambley, T. (2001). Platinum binding to DNA:
Structural controls and consequences. Dalton
Transactions: an international journal of
inorganic, organometallic and bioinorganic
chemistry, 2001, 2711-2718.
Field, L., Soler, L., Buys, I., Hambley, T.,
Messerle, B. (2001). Polypyrazolylmethane
complexes of ruthenium. Dalton Transactions:
an international journal of inorganic,
organometallic and bioinorganic chemistry,
2001, 1959-1965.
Morgan, Y., Turner, P., Kennedy, B., Hambley,
T., Lay, P., Biffin, J., Regtop, H., Warwick, B.
(2001). Preparation and characterization of
dinuclear copper-indomethacin
anti-inflammatory drugs. Inorganica Chimica
Acta, 324, 150-161.
Hall, M., Dillon, C., Hambley, T., Davies, M.,
Price, A. (2001). Reactions and reduction of
platinum(IV) anticancer complexes. 10th
International Conference on Bioinorganic
Chemistry, : Ads & Adea.
Hambley, T., Ling, E., Munk, V., Davies, M.
(2001). Steric control of stereoselective
interactions between the platinum(II) complex
[PtCl2(1,4-diazacycloheptane)] and DNA:
Comparison with cis-[PtCl2(NH3)2] and
[PtCl2(ethane-1,2-diamine)] using DNA binding
and molecular modeling studies. Journal of
Biological Inorganic Chemistry, 6(5-6), 534-542.
Hambley, T., Habtemariam,, A., Parkinson, J.,
Margiotta, N., Parsons, S., Sadler, P. (2001).
Structure and dynamics of a platinum(II)
aminophosphine complex and its nucleobase
adducts. Dalton Transactions: an international
journal of inorganic, organometallic and
bioinorganic chemistry, 2001, 362-372.
Davies, M., Diakos, C., Messerle, B., Hambley,
T. (2001). Structure, stability, and
interconversion barriers of the rotamers of
cis-[PtIICl2(quinoline)2] and
cis-[[PtIICl2(3-bromoquinoline)(quinoline)]
from X-ray crystallography, NMR spectroscopy
and molecular mechanics evidence. Inorganic
Chemistry, 40, 3048-3054.
Giannikopoulos, G., Carter, J., Fenton, R.,
Hambley, T. (2001). The synthesis of
ethane-1,2-diamine-N,N'-bis(methylenephosphon
ic) acid and its platinum(II) complex,
Bisethane-1,2-diamine-N,N'-bis(methylenephosp
honato)platinum(II). Australian Journal of
Chemistry, 54, 127-130.
Liu, X., Kassiou, M., Christie, M., Hambley, T.
(2001). Trishomocubanes: requirements for
sigma receptor binding and subtype selectivity.
Australian Journal of Chemistry, 54, 31-36.
Burns, C., Field, L., Hambley, T., Lin, T.,
Ridley, D., Turner, P., Wilkinson, M. (2001).
X-ray crystal structural determination of
copper(II)-nitrilotriacetic
acid-Bis(N-methylimidazol-2-yl)ketone ternary
complex. ARKIVOC, vii, 157-165.
2000
Codd, R., Levina, A., Zhang, L., Hambley, T.,
Lay, P. (2000). Characterization and X-ray
absorption spectroscopic studies of
bis[quinato(2)]oxochromate(V). Inorganic
Chemistry, 39(5), 990-997.