Publications for Colin Dunstan 2016

Publications for Colin Dunstan

2016

Ark, M., Tran, G., Chen, Y., Boughton, P.,

Cosman, P., Dunstan, C. (2016). Characterisation of a novel light activated adhesive scaffold:

Potential for device attachment. Journal of the

Mechanical Behavior of Biomedical Materials ,

62, 433-445. <a href="http://dx.doi.org/10.1016/j.jmbbm.2016.05

.029">[More Information]</a>

Li, J., Roohaniesfahani, S., Dunstan, C., Quach,

T., Steck, R., Saifzadeh, S., Pivonka, P., Zreiqat,

H. (2016). Efficacy of novel synthetic bone substitutes in the reconstruction of large segmental bone defects in sheep tibiae.

Biomedical Materials (Bristol) , 11(1), 1-12. <a href="http://dx.doi.org/10.1088/1748-6041/11/1/

015016">[More Information]</a>

2015

Zreiqat, H., Dunstan, C., Rosen, V. (2015). A

Tissue Regneration Approach to Bone and

Cartilage Repair . Cham: Springer.

Sirisa-Ard, A., Michael, S., Ahmed, K., Dunstan,

C., Pearce, S., Bilgin, A., Dalci, O., Darendeliler,

M. (2015). Histomorphological and torque removal comparison of 6mm orthodontic miniscrews with and without surface treatment in

New Zealand rabbits. European Journal of

Orthodontics , 37(6), 578-583. <a href="http://dx.doi.org/10.1093/ejo/cju077">[Mo re Information]</a>

Taylor, M., Ruys, A., Dunstan, C., Shami, G.,

Agus, H. (2015). Medical Science As a useful adjunct to the biomedical engineering degree: A discussion of its' relevance in the context of implants. Australian Biomedical Engineering

Conference 2015 , Barton, ACT: Engineers

Australia.

Chen, Y., Roohaniesfahani, S., Lu, Z., Zreiqat,

H., Dunstan, C. (2015). Zirconium Ions

Up-Regulate the BMP/SMAD Signaling pathway and Promote the Proliferation and Differentiation of Human Osteoblasts. PloS One , 10(1), 1-17. <a href="http://dx.doi.org/10.1371/journal.pone.011


2014

Lu, Z., Wang, G., Roohaniesfahani, S., Dunstan,

C., Zreiqat, H. (2014). Baghdadite Ceramics

Modulate the Cross Talk Between Human

Adipose Stem Cells and Osteoblasts for Bone

Regeneration. Tissue Engineering. Part A ,

20(5-6), 992-1002. <a href="http://dx.doi.org/10.1089/ten.TEA.2013.04


Hossain, M., Dunstan, C. (2014). Bone

Publications for Colin Dunstan microenvironment and its role in bone metastasis. Cancer Forum , 38(2), 129-132.

Zheng, Y., Chow, S., Boernert, K., Basel, D.,

Mikuscheva, A., Kim, S., Fong

�

?Yee, C.,

Trivedi, T., Buttgereit, F., Sutherland, R.,

Dunstan, C., Zhou, H., Seibel, M. (2014). Direct

Crosstalk Between Cancer and Osteoblast

Lineage Cells Fuels Metastatic Growth in Bone via Auto-Amplification of IL-6 and RANKL

Signaling Pathways. Journal of Bone and

Mineral Research , 29(9), 1938-1949. <a href="http://dx.doi.org/10.1002/jbmr.2231">[Mo re Information]</a>

Roohaniesfahani, S., Wong, K., Lu, Z., Chen, Y.,

Li, J., Gronthos, S., Menicanin, D., Shi, J.,

Dunstan, C., Zreiqat, H. (2014). Fabrication of a novel triphasic and bioactive ceramic and evaluation of its in vitro and in vivo cytocompatibility and osteogenesis. Journal of

Materials Chemistry B , 2(13), 1866-1878. <a href="http://dx.doi.org/10.1039/C3TB21504K">

[More Information]</a>

Davies, B., King, A., Newman, P., Minett, A.,

Dunstan, C., Zreiqat, H. (2014). Hypothesis:

Bones Toughness Arises from the Suppression of

Elastic Waves. Scientific Reports , 4(7538), 1-6.

<a href="http://dx.doi.org/10.1038/srep07538">[Mo re Information]</a>

Scheiner, S., Pivonka, P., Smith, D., Dunstan, C.,

Hellmich, C. (2014). Mathematical modeling of postmenopausal osteoporosis and its treatment by the anti-catabolic drug denosumab.

International Journal for Numerical Methods in

Biomedical Engineering , 30(1), 1-27. <a href="http://dx.doi.org/10.1002/cnm.2584">[Mo re Information]</a>

Zheng, Y., Basel, D., Chow, S., Fong-Yee, C.,

Kim, S., Buttgereit, F., Dunstan, C., Zhou, H.,

Seibel, M. (2014). Targeting IL-6 and RANKL signaling inhibits prostate cancer growth in bone.

Clinical and Experimental Metastasis , 31(8),

921-933. <a href="http://dx.doi.org/10.1007/s10585-014-968

0-3">[More Information]</a>

Dunstan, C. (2014). Vitamin D supplementation and bone mineral density: Wat about the natural history of bone loss? The Lancet , 383(2014),

1292-1292.

Dunstan, C. (2014). Vitamin D supplements and bone mineral density (II). The Lancet ,

383(9925), 1292-1292. <a href="http://dx.doi.org/10.1016/S0140-6736(14)


2013

Lu, Z., Wang, G., Dunstan, C., Chen, Y., Lu, W.,

Davies, B., Zreiqat, H. (2013). Activation and

Promotion of Adipose Stem Cells by Tumour

Necrosis Factor-Alpha Preconditioning for Bone

Regeneration. Journal of Cellular Physiology ,

228(8), 1737-1744. <a href="http://dx.doi.org/10.1002/jcp.24330">[Mo re Information]</a>

Pivonka, P., Buenzli, P., Scheiner, S., Hellmich,

C., Dunstan, C. (2013). The influence of bone surface availability in bone remodelling-A mathematical model including coupled geometrical and biomechanical regulations of bone cells. Engineering Structures , 47, 134-147.

<a href="http://dx.doi.org/10.1016/j.engstruct.2012.

09.006">[More Information]</a>

Zheng, Y., Zhou, H., Dunstan, C., Sutherland,

R., Seibel, M. (2013). The role of the bone microenvironment in skeletal metastasis. Journal of Bone Oncology , 2(1), 47-57. <a href="http://dx.doi.org/10.1016/j.jbo.2012.11.00


Roohaniesfahani, S., Dunstan, C., Li, J., Lu, Z.,

Davies, B., Pearce, S., Field, J., Williams, R.,

Zreiqat, H. (2013). Unique microstructural design of ceramic scaffolds for bone regeneration under load. Acta Biomaterialia , 9(6), 7014-7024.

<a href="http://dx.doi.org/10.1016/j.actbio.2013.02.


2012

Pivonka, P., Buenzli, P., Dunstan, C. (2012). A

Systems Approach to Understanding Bone Cell

Interactions in Health and Disease. In

Sivakumar Gowder (Eds.), Cell Interaction , (pp.

169-204). Rijeka, Croatia: InTech Publishers.

Smith, D., Gardiner, B., Dunstan, C. (2012).

Bone Balance within a Cortical BMU: Local

Controls of Bone Resorption and Formation.

PloS One , 7(7), 1-12. <a href="http://dx.doi.org/10.1371/journal.pone.004


Speranza, T., Henneicke, H., Gasparini, S.,

Blankenstein, K., Heinevetter, U., Cogger, V.,

Svistounov, D., Zhang, Y., Cooney, G.,

Buttgereit, F., Dunstan, C., Zhou, H., Seibel, M., et al (2012). Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism.

Journal of Clinical Investigation , 122(11),

4172-4189. <a href="http://dx.doi.org/10.1172/JCI63377">[Mor e Information]</a>

Lu, W., McKenzie, D., Dunstan, C., Zreiqat, H.,

Bilek, M. (2012). Plasma Immersion Ion

Implantation Treatment of Poly-ether Ether

Ketone for the Immobilization of Biomolecules on Surfaces (ID: 836). International Forum of

Biomedical Materials: Nanobiomaterials for

Publications for Colin Dunstan

Tissue Regeneration .

Roohaniesfahani, S., Dunstan, C., Davies, B.,

Pearce, S., Williams, R., Zreiqat, H. (2012).

Repairing a critical-sized bone defect with highly porous modified and unmodified baghdadite scaffolds. Acta Biomaterialia , 8(11), 4162-4172.

<a href="http://dx.doi.org/10.1016/j.actbio.2012.07.


Pivonka, P., Dunstan, C. (2012). Role of mathematical modeling in bone fracture healing.

BoneKEy Reports , Report 1 (2012),

221-1-221-10. <a href="http://dx.doi.org/10.1038/bonekey.2012.22


Lu, Z., Wang, G., Dunstan, C., Zreiqat, H.

(2012). Short-Term Exposure to Tumor Necrosis

Factor-Alpha Enables Human Osteoblasts to

Direct Adipose Tissue-Derived Mesenchymal

Stem Cells into Osteogenic Differentiation. Stem

Cells and Development , 21(13), 2420-2429. <a href="http://dx.doi.org/10.1089/scd.2011.0589">

[More Information]</a>

Kam, W., Meikle, S., Dunstan, C., Banati, R.

(2012). The 18 kDa Translocator Protein

(Peripheral

Benzodiazepine Receptor) Expression in the

Bone of

Normal, Osteoprotegerin or Low Calcium Diet

Treated

Mice. PloS One , 7(1), 1-10. <a href="http://dx.doi.org/10.1371/journal.pone.003


2011

Stalgis-Bilinski, K., Boyages, J., Salisbury, E.,

Dunstan, C., Henderson, S., Talbot, P. (2011).

Burning daylight: balancing vitamin D requirements with sensible sun exposure.

Medical Journal of Australia , 194(7), 345-348.

<a href="http://www.ncbi.nlm.nih.gov/entrez/query.

fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract

&list_uids=21470084">[More Information]</a>

Wang, Y., Pivonka, P., Buenzli, P., Smith, D.,

Dunstan, C. (2011). Computational Modeling of

Interactions between Multiple Myeloma and the

Bone Microenvironment. PloS One , 6(11), e27494-1-e27494-21. <a href="http://dx.doi.org/10.1371/journal.pone.002


Henneicke, H., Herrmann, M., Kalak, R.,

Speranza, T., Bertollo, N., Day, R., Huscher, D.,

Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H.

(2011). Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism. Bone , 49(4),


733-742. <a href="http://dx.doi.org/10.1016/j.bone.2011.06.0


Fiford, R., Tomitsch, M., Dunstan, C., Plumbe,

R. (2011). Exploring how elements of studio teaching can improve student engagement.

Synergy , 31(July), 46-52.

Ooi, L., Zheng, Y., Stalgis-Bilinski, K., Dunstan,

C. (2011). The bone remodeling environment is a factor in breast cancer bone metastasis. Bone ,

48(1), 66-70. <a href="http://dx.doi.org/10.1016/j.bone.2010.05.0


2010

Goldhahn, J., Little, D., Mitchell, P., Fazzalari,

N., Reid, I., Aspenberg, P., Marsh, D., Augat, P.,

Bavonratanavech, S., Bostrom, M., Dunstan, C., et al (2010). Evidence for anti-osteoporosis therapy in acute fracture situations-Recommendations of a multidisciplinary workshop of the International

Society for Fracture Repair. Bone , 46(2),



Allan, C., Kalak, R., Dunstan, C., McTavish, K.,

Zhou, H., Handelsman, D., Seibel, M. (2010).

Follicle-stimulating hormone increases bone mass in female mice. Proceedings of the

National Academy of Sciences of the United

States of America (PNAS) , 107(52),

22629-22634. <a href="http://dx.doi.org/10.1073/pnas.101214110


Liu, P., Kalak, R., Lue, Y., Jia, Y., Erkkila, K.,

Zhou, H., Seibel, M., Wang, C., Swerdloff, R.,

Dunstan, C. (2010). Genetic and Hormonal

Control of Bone Volume, Architecture, and

Remodeling in XXY Mice. Journal of Bone and

Mineral Research , 25(10), 2148-2154. <a href="http://dx.doi.org/10.1002/jbmr.104">[Mor e Information]</a>

Weber, A., Li, G., Kalak, R., Street, J.,

Buttgereit, F., Dunstan, C., Seibel, M., Zhou, H.

(2010). Osteoblast-targeted disruption of glucocorticoid signalling does not delay intramembranous bone healing. Steroids , 75(3),

282-286. <a href="http://dx.doi.org/10.1016/j.steroids.2010.0


Zreiqat, H., Ramaswamy, Y., Wu, C.,

Paschalidis, A., Lu, Z., James, B., Birke, O.,

McDonald, M., Little, D., Dunstan, C. (2010).

The incorporation of strontium and zinc into a calcium-silicon ceramic for bone tissue engineering. Biomaterials , 31(12), 3175-3184.

<a href="http://dx.doi.org/10.1016/j.biomaterials.20

10.01.024">[More Information]</a>

Buenzli, P., Pivonka, P., Gardiner, B., Smith, D.,

Dunstan, C., Mundy, G. (2010). Theoretical analysis of the spatio-temporal structure of bone multicellular units. 9th World Congress on

Computational Mechanics and 4th Asian Pacific

Congress on Computational Mechanics

WCCM-APCOM 2010 , Sydney: IOP Publishing.

<a href="http://dx.doi.org/10.1088/1757-899X/10/1/


Ooi, L., Zheng, Y., Zhou, H., Trivedi, T.,

Conigrave, A., Seibel, M., Dunstan, C. (2010).

Vitamin D deficiency promotes growth of

MCF-7 human breast cancer in a rodent model of osteosclerotic bone metastasis. Bone , 47(4),



Ooi, L., Zhou, H., Kalak, R., Zheng, Y.,

Conigrave, A., Seibel, M., Dunstan, C. (2010).

Vitamin D deficiency promotes human breast cancer growth in a murine model of bone metastasis. Cancer Research , 70(5), 1835-1844.

<a href="http://dx.doi.org/10.1158/0008-5472.CAN

-09-3194">[More Information]</a>

Zheng, Y., Zhou, H., Ooi, L., Snir, A., Dunstan,

C., Seibel, M. (2010). Vitamin D deficiency promotes prostate cancer growth in bone. The

Prostate , , 1-10. <a href="http://dx.doi.org/10.1002/pros.21316">[M ore Information]</a>

2009

Mak, W., Shao, X., Dunstan, C., Seibel, M.,

Zhou, H. (2009). Biphasic

Glucocorticoid-Dependent Regulation of Wnt

Expression and Its Inhibitors in Mature

Osteoblastic Cells. Calcified Tissue

International , 85(6), 538-545. <a href="http://dx.doi.org/10.1007/s00223-009-930


Wang, C., Karlis, G., Anderson, G., Dunstan, C.,

Carbone, A., Berger, G., Ploska, U., Zreiqat, H.

(2009). Bone growth is enhanced by novel bioceramic coatings on Ti alloy implants.

Journal of Biomedical Materials Research. Part

A , 90A(2), 419-428. <a href="http://dx.doi.org/10.1002/jbm.a.32111">[

More Information]</a>

Zhou, H., Chen, D., Dunstan, C., Seibel, M.

(2009). Bone Metabolism. In Stefan

Offermanns, Walter Rosenthal (Eds.), Bone

Metabolism . (Vol. 1, pp. 276-282). USA:

Springer.

Dunstan, C., Ooi, L. (2009). CXCL12/CXCR4


Axis in Tissue Targeting and Bone Destruction in Cancer and Multiple Myeloma. Journal of

Bone and Mineral Research , 24(7), 1147-1149.

<a href="http://dx.doi.org/10.1359/jbmr.090503">[

More Information]</a>

Kalak, R., Zhou, H., Street, J., Day, R.,

Modzelewski, J., Spies, C., Liu, P., Li, G.,

Dunstan, C., Seibel, M. (2009). Endogenous glucocorticoid signaling in osteoblasts is necessary to maintain normal bone structure in mice. Bone , 45(1), 61-67. <a href="http://dx.doi.org/10.1016/j.bone.2009.03.6


Zhou, H., Mak, W., Kalak, R., Street, J.,

Fong-Yee, C., Zheng, Y., Dunstan, C., Seibel, M.

(2009). Glucocorticoid-dependent Wnt signaling by mature osteoblasts is a key regulator of cranial skeletal development in mice.

Development (Cambridge) , 136(3), 427-436. <a href="http://dx.doi.org/10.1242/dev.027706">[M ore Information]</a>

Dunstan, C. (2009). How can periodontal bone loss be stopped? In Seymour, R; Henderson,

B; Donas, N; Curtis, M. (Eds.), Periodontal

Medicine and Systems Biology , (pp. 427-237).

Chichester, UK: Wiley-Blackwell Publishing.

Blair, J., Modzelewski, J., Perryman, L., Russell,

P., Seibel, M., Dunstan, C. (2009). Prolonged

Antiresorptive Treatment of Lytic Prostate

Cancer Xenografts in Mouse Bone Results in

Tumor Necrosis. Journal of Cancer Molecules ,

4(6), 175-181.

Ramaswamy, Y., Wu, C., Dunstan, C., Hewson,

B., Eindorf, T., Anderson, G., Zreiqat, H. (2009).

Sphene ceramics for orthopedic coating applications: An in vitro and in vivo study. Acta

Biomaterialia , 5(8), 3192-3204. <a href="http://dx.doi.org/10.1016/j.actbio.2009.04.


Herrmann, M., Henneicke, H., Street, J.,

Modzelewski, J., Kalak, R., Buttgereit, F.,

Dunstan, C., Zhou, H., Seibel, M. (2009). The challenge of continuous exogenous glucocorticoid administration in mice. Steroids ,

74(2), 245-249. <a href="http://dx.doi.org/10.1016/j.steroids.2008.1


Pivonka, P., Zimak, J., Smith, D., Gardiner, B.,

Dunstan, C., Sims, N., Martin, T., Mundy, G.

(2009). Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling. Journal of Theoretical Biology ,

262(2), 306-316. <a href="http://dx.doi.org/10.1016/j.jtbi.2009.09.02


Buttgereit, F., Zhou, H., Kalak, R., Gaber, T.,

Spies, C., Huscher, D., Straub, R., Modzelewski,

J., Dunstan, C., Seibel, M. (2009). Transgenic

Disruption of Glucocorticoid Signaling in

Mature Osteoblasts and Osteocytes Attenuates

K/BxN Mouse Serum-Induced Arthritis In Vivo.

Arthritis Care and Research , 60(7), 1998-2007.

<a href="http://dx.doi.org/10.1002/art.24619">[Mor e Information]</a>

2008

Zheng, Y., Zhou, H., Fong-Yee, C.,

Modzelewski, J., Seibel, M., Dunstan, C. (2008).

Bone Resorption increases tumour growth in a mouse model of osteosclerotic breast cancer metastasis. Clinical and Experimental

Metastasis , 25(5), 559-567. <a href="http://dx.doi.org/10.1007/s10585-008-917


Pivonka, P., Zimak, J., Smith, D., Gardiner, B.,

Dunstan, C., Sims, N., Martin, T., Mundy, G.

(2008). Model structure and control of bone remodeling: A theoretical study. Bone , 43,



Zhou, H., Mak, W., Zheng, Y., Dunstan, C.,

Seibel, M. (2008). Osteoblasts directly control lineage commitment of mesenchymal progenitor cells through WNT signaling. Journal of

Biological Chemistry , 283(4), 1936-1945. <a href="http://dx.doi.org/10.1074/jbc.M702687200

">[More Information]</a>

2007

Zheng, Y., Zhou, H., Modzelewski, J., Kalak, R.,

Blair, J., Seibel, M., Dunstan, C. (2007).

Accelerated bone resorption, due to dietary calcium deficiency, promotes breast cancer tumor growth in bone. Cancer Research , 67(19),

9542-9548. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Dunstan, C., Blair, J., Zhou, H., Seibel, M.

(2007). Bone, Mineral, Connective Tissue

Metabolism. In Taylor J; Triggle D (vol ed

Michael Williams) (Eds.), Comprehensive

Medicinal Chemistry II , (pp. 495-520). Oxford,

United Kingdom: Elsevier.

Dunstan, C., Felsenberg, D., Seibel, M. (2007).

Therapy insight: The risks and benefits of bisphosphonates for the treatment of tumor-induced bone disease. Nature Clinical

Practice Oncology , 4(1), 42-45. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Liu, P., Kalak, R., Lue, Y., Erkkilla, K.,


Simanainen, U., Zhou, H., Hikim, A.,

Handelsman, D., Seibel, M., Wang, C., Dunstan,

C., et al (2007). XXY Mice have an Osteoporotic

Phenotype. <i>29th Annual Meeting

American Society for Bone and Mineral

Research (ASBMR)</i>, Washington DC, USA:

American Society for Bone and Mineral

Research.

2006

Zheng, Y., Brennan, K., Blair, J., Modzelewski,

J., Seibel, M., Dunstan, C. (2006). Inhibition of bone resorption, rather than direct cytotoxicity, mediates the anti-tumour actions of ibandronate and osteoprotegerin in a murine model of breast cancer bone metastasis. Bone , 40(2), 471-478. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Blair, J., Zhou, H., Seibel, M., Dunstan, C.

(2006). Mechanisms of disease: roles of OPG,

RANKL and RANK in the pathophysiology of skeletal metastasis. Nature Clinical Practice

Oncology , 3(1), 41-49. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Blair, J., Zheng, Y., Dunstan, C. (2006). RANK ligand. The International Journal of

Biochemistry and Cell Biology , 39(6),

1077-1081. <a href="http://dx.doi.org/10.1016/j.biocel.2006.11.


Meier, C., Meinhardt, U., Greenfield, J.,

Modzelewski, J., Nguyen, T., Dunstan, C.,

Seibel, M. (2006). Serum cathepsin K concentrations reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget's disease. Clinical

Laboratory , 52(1-2), 1-10. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Seibel, M., Dunstan, C., Zhou, H., Allan, C.,

Handelsman, D. (2006). Sex steroids, not FSH, influence bone mass. Cell , 127(6), 1079-1079. <a href="http://dx.doi.org/10.1016/j.cell.2006.12.00


Geusens, P., Landewé, R., Garnero, P., Chen, D.,

Dunstan, C., Lems, W., Stinissen, P., van der

Heijde, D., van der Linden, S., Boers, M. (2006).

The ratio of circulating osteoprotegerin to

RANKL in early rheumatoid arthritis predicts later joint destruction. Arthritis & Rheumatology ,

54(6), 1772-1777. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Padagas, J., Colloton, M., Shalhoub, V.,

Kostenuik, P., Morony, S., Munyakazi, L., Guo,

M., Gianneschi, D., Shatzen, E., Dunstan, C., et al (2006). The receptor activator of nuclear factor-kappa B ligand inhibitor osteoprotegerin is a bone-protective agent in a rat model of chronic renal insufficiency and hyperparathyroidism.

Calcified Tissue International , 78(1), 35-44.

2005

Valenta, A., Roschger, P., Fratzl-Zelman, N.,

Kostenuik, P., Dunstan, C., Fratzl, P.,

Klaushofer, K. (2005). Combined treatment with

PTH (1-34) and OPG increases bone volume and uniformity of mineralization in aged ovariectomized rats. Bone , 37(1), 87-95. <a href="http://dx.doi.org/10.1016/j.bone.2005.03.0


Seibel, M., Blair, J., Perryman, L., Pwint, H.,

Lelliott, J., De Winter, J., Russell, P., Dunstan,

C. (2005). Osteoprotegerin treatment inhibits the growth of lytic prostate cancer lesions in bone.

2nd Joint Meeting of the European Calcified

Tissue Society and the International Bone and

Mineral Society , New York: Elsevier Science.

Meier, C., Meinhardt, U., Greenfield, J.,

Dunstan, C., Seibel, M. (2005). Serum cathepsin

K levels reflect osteoclastic activity in women with postmenopausal osteoporosis and patients with Paget''s disease. 2nd Joint Meeting of the

European Calcified Tissue Society and the

International Bone and Mineral Society , New

York: Elsevier Science.

Morony, S., Warmington, K., Adamu, S.,

Asuncion, F., Geng, Z., Grisanti, M., Tan, H.,

Capparelli, C., Starnes, C., Dunstan, C., et al

(2005). The Inhibition of RANKL Causes

Greater Suppression of Bone Resorption and Hypercalcemia

Compared with Bisphosphonates in Two Models of Humoral

Hypercalcemia of Malignancy. Endocrinology ,

146(8), 3235-3243. <a href="http://www.ncbi.nlm.nih.gov/entrez/query.



Dunstan, C. (2005). The role of RANK, RANK ligand and osteoprotegerin in the lytic effects and growth of bone metastases. In Claude Jasmin,

Lawrence R. Coia, Rodolfo Capanna, Gerard

Saillant (Eds.), Textbook of bone metastases , (pp.

51-62). United States: John Wiley & Sons.

2004

Bekker, P., Holloway, D., Rasmussen, A.,

Murphy, R., Martin, S., Leese, P., Holmes, G.,

Dunstan, C., DePaoli, A. (2004). A single dose placebo-controlled study of AMG 162, a fully

Publications for Colin Dunstan human monoclonal antibody to RANKL, in postmenopausal women. Journal of Bone and

Mineral Research , 19(7), 1059-1066.

Theoleyre, S., Wittrant, Y., Couillaud, S., Vusio,

P., Berreur, M., Dunstan, C., Blanchard, F.,

Rédini, F., Heymann, D. (2004). Cellular activity and signaling induced by osteoprotegerin in osteoclasts: involvement of receptor activator of nuclear factor kB ligand and MAPK. BBA:

Biochimica et Biophysica Acta - Molecular Cell

Research , 1644 (1), 1-7. <a href="http://dx.doi.org/10.1016/j.bbamcr.2003.1


Dunstan, C., Zhou, H., Seibel, M. (2004).

Fibroblast Growth Factor 23: A Phospatonin

Regulating Phosphate Homeostasis?

Endocrinology , 145(7), 3084-3086.

Wittrant, Y., Theoleyre, S., Couillaud, S.,

Dunstan, C., Heymann, D., Redini, F. (2004).

Relevance of an in vitro osteoclastogenesis system to study receptor activator of NF-kB ligand and osteoprotegerin biological activities.

Experimental Cell Research , 293(2), 292-301.

Zwerina, J., Hayer, S., Tohidast-Akrad, M.,

Bergmeister, H., Redlich, K., Feige, U., Dunstan,

C., Kollias, G., Steiner, G., Smolen, J., et al

(2004). Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Care and Research , 50(1), 277-290.

Kiefer, J., Vessella, R., Quinn, J., Odman, A.,

Zhang, J., Keller, E., Kostenuik, P., Dunstan, C.,

Corey, E. (2004). The effect of osteoprotegerin administration on the intra-tibial growth of the osteoblastic LuCaP 23.1 prostate cancer xenograft. Clinical and Experimental Metastasis ,

21(5), 381-387. <a href="http://dx.doi.org/10.1007/s10585-004-286


2003

Body, J., Greipp, P., Coleman, R., Facon, T.,

Geurs, F., Fermand, J., Harousseau, J., Lipton,

A., Mariette, X., Williams, C., Dunstan, C., et al

(2003). A Phase 1 Study of AMGN-0007, a

Recombinant Osteoprotegerin Construct, in

Patients with Multiple Myeloma or Breast

Cancer-Related Bone Metastases. Cancer , 97(3),

887-892.

Smith, B., Cosenza, M., Mancini, A., Dunstan,

C., Gregson, R., Martin, S., Smith, S., Davis, H.

(2003). A toxicity profile of osteoprotegerin in the cynomolgus monkey. International Journal of Toxicology , 22, 403-412.

Doherty, T., Asotra, K., Fitzpatrick, L., Qiao, J.,

Wilkin, D., Detrano, R., Dunstan, C., Shah, P.,

Rajavashisth, T. (2003). Calcification in atherosclerosis: Bone biology and chronic inflammation at the arterial crossroads.

Proceedings of the National Academy of

Sciences of the United States of America (PNAS) ,

100(20), 11201-11206.

Ashcroft, A., Cruickshank, S., Croucher, P.,

Perry, M., Rollinson, S., Lippitt, J., Child, J.,

Dunstan, C., Felsburg, P., Morgan, G., et al

(2003). Colonic dendritic cells, intestinal inflammation, and T cell-mediated bone destruction are modulated by recombinant osteoprotegerin. Immunity , 19, 849-861.

Riggs, B., Khosla, S., Atkinson, E., Dunstan, C.,

Melton, L. (2003). Evidence that type I osteoporosis results from enhanced responsiveness of bone to estrogen deficiency.

Osteoporosis International , 14, 728-733. <a href="http://dx.doi.org/10.1007/s00198-003-143


Fohr, B., Dunstan, C., Seibel, M. (2003).

Markers of bone remodeling in metastatic bone disease. Journal of Clinical Endocrinology and

Metabolism , 88(11), 5059-5075.

Schett, G., Redlich, K., Hayer, S., Zwerina, J.,

Bolon, B., Dunstan, C., Gortz, B., Schulz, A.,

Bergmeister, H., Kollias, G., et al (2003).

Osteoprotegerin protects against generalized bone loss in tumor necrosis factor-transgenic mice. Arthritis Care and Research , 48(7),

2042-2051. <a href="http://dx.doi.org/10.1002/art.11150">[Mor e Information]</a>

Wittrant, Y., Theoleyre, S., Couillaud, S.,


Regulation of osteoclast protease expression by

RANKL. Biochemical and Biophysical Research

Communications , 310, 774-778. <a href="http://dx.doi.org/10.1016/j.bbrc.2003.09.0


Capparelli, C., Morony, S., Warmington, K.,

Adamu, S., Lacey, D., Dunstan, C., Stouch, B.,

Martin, S., Kostenuik, P. (2003). Sustained anti-resorptive effects after a single treatment with human recombinant osteoprotegerin (OPG): a pharmacodynamic and pharmacokinetic analysis in rats. Journal of Bone and Mineral

Research , 18(5), 852-858.

2002

Khosla, S., Arrighi, H., Melton, L., Atkinson, E.,

O'Fallon, W., Dunstan, C., Riggs, B. (2002).

Correlates of osteoprotegerin levels in women and men. Osteoporosis International , 13(5),

394-399.

Khosla, S., Atkinson, E., Dunstan, C., O'Fallon,

W. (2002). Effect of estrogen versus testosterone on circulating osteoprotegerin and other cytokine

Publications for Colin Dunstan levels in normal elderly men. Journal of Clinical

Endocrinology and Metabolism , 87(4),

1550-1554.

Wittrant, Y., Couillaud, S., Theoleyre, S.,


Osteoprotegerin differentially regulates protease expression in osteoclast cultures. Biochemical &

Biophysical Research Communications.

Biochemical and Biophysical Research

Communications , 293, 38-44.

Romas, E., Sims, N., Hards, D., Lindsay, M.,

Quinn, J., Ryan, P., Dunstan, C., Martin, T.,

Gillespie, M. (2002). Osteoprotegerin Reduces

Osteoclast Numbers and Prevents Bone Erosion in Collagen-Induced Arthritis. The American

Journal of Pathology , 161(4), 1419-1427.

Doherty, T., Uzui, H., Fitzpatrick, L., Tripathi,

P., Dunstan, C., Asotra, K., Rajavashisth, T.

(2002). Rationale for the role of osteoclast-like cells in arterial calcification. The F A S E B

Journal , 16, 577-582.

Lipton, A., Ali, S., Leitzel, K., Chinchilli, V.,

Witters, L., Engle, L., Holloway, D., Bekker, P.,

Dunstan, C. (2002). Serum osteoprotegerin levels in healthy controls and cancer patients. Clinical

Cancer Research , 8, 2306-2310.

Redlich, K., Hayer, S., Maier, A., Dunstan, C.,

Tohidast-Akrad, M., Lang, S., Turk, B.,

Pietschmann, P., Woloszczuk, W., Haralambous,

S., et al (2002). Tumor Necrosis Factor alpha -

Mediated Joint Destruction Is Inhibited by

Targeting Osteoclasts With Osteoprotegerin.

Arthritis Care and Research , 46(3), 785-792.

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