APPLICATION OF NEGATIVE BINOMIAL AND LINEAR REGRESSION ANALYSIS IN ASSESSING SPATIAL AND TEMPORAL TRENDS OF ALCOHOL OUTLET DENSITY AND AGGRAVATED ASSAULT IN THE CITY OF PITTSBURGH BETWEEN 2000 AND 2012 by Phyon K. Christopher BS, Mathematics, University of the Virgin Islands, 2005 Submitted to the Graduate Faculty of Epidemiology Graduate School of Public Health in partial fulfillment of the requirements for the degree of Master of Public Health University of Pittsburgh 2015 UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH This essay is submitted by Phyon K. Christopher on July 30, 2015 and approved by Essay Advisor: Anthony Fabio, PhD, MPH Assistant Professor Department of Epidemiology Graduate School of Public Health University of Pittsburgh ______________________________________ Essay Reader: Tiffany L. Gary-Webb, PhD, MHS ______________________________________ Associate Professor Department of Behavioral and Community Health Sciences Graduate School of Public Health University of Pittsburgh ii Copyright © by Phyon K. Christopher 2015 iii Anthony Fabio, PhD, MPH APPLICATION OF NEGATIVE BINOMIAL AND LINEAR REGRESSION ANALYSIS IN ASSESSING SPATIAL AND TEMPORAL TRENDS OF ALCOHOL OUTLET DENSITY AND AGGRAVATED ASSAULT IN THE CITY OF PITTSBURGH BETWEEN 2000 AND 2012 Phyon Christopher, MPH University of Pittsburgh, 2015 ABSTRACT Objective: This study examines the public health significance of recent legislature change which allows for the acquisition of a wider variety of alcohol retail licenses. The temporal trend in alcohol retail density and its effect on aggravated assault in the city of Pittsburgh is assessed by comparing data from 2000 and 2012. Previous studies have concluded that there is an association between alcohol outlet density (AOD) and violence, but many of these studies are inconsistent with some reporting an association between AOD and violence and others reporting no increase in risk of violence. Methods: Data for this study was geocoded to determine alcohol outlet density within Pittsburgh from InfoUSA and Dun&Bradstreet; population and demographic data was geocoded from the US Census Bureau; neighborhood level rates of violence were calculated from data provided by the Pittsburgh police department; and data pertaining to 11 neighborhood characteristics were extracted from Summary File 1 and Summary File 3 of the 2000 and 2010 US Census. The association between AOD and violence was assessed using negative binomial regression; the temporal relationship was assessed using linear regression modeling. As a proxy for commercial activity, “restaurant outlet density” (restaurants) was added to the negative binomial models to check for robustness. iv Results: The model building process produced 16 results: 8 for data where the rates were divided per capita and 8 where the rates were divided per square miles. In 2000 all models produced the same result. Initially they were significant and became non-significant once “restaurants” was added to the model. In 2012 almost all models remained significant after adding restaurants except for the off-premise alcohol retail density per square miles rates in 2012. In 2012 some of the models also changed from positive to negative association after adding restaurants to the models. The linear models all showed that there was no association between the change in AOD and the change in aggravated assault. Conclusions: The results of this study suggest a weak or no association between AOD and aggravated assault. When models are created without “restaurants” added, all models produce relative risk values approximately equal to 1 which shows that AOD does not impact the risk of violence. After restaurants are added to the model almost all predictors of interest become nonsignificant. These two results confirm that the association either isn’t present or is not as strong as previous literature reported. v TABLE OF CONTENTS PREFACE .................................................................................................................................... XI 1.0 INTRODUCTION ........................................................................................................ 1 2.0 METHODS.................................................................................................................... 4 2.1 DATA SOURCES ................................................................................................ 4 2.2 DATA ANALYSIS ............................................................................................... 7 2.3 CONCEPTUAL FRAMEWORK....................................................................... 8 3.0 RESULTS ...................................................................................................................... 9 3.1 MODELS FOR POPULATION RATES 2000.................................................. 9 3.2 MODELS FOR POPULATION RATES 2012................................................ 11 3.3 MODELS FOR CHANGE IN POPULATION RATES................................. 13 3.4 MODELS FOR SQUARE MILES RATES 2000 ............................................ 15 3.5 MODELS FOR SQUARE MILES RATES 2012 ............................................ 17 3.6 MODELS FOR CHANGE IN SQUARE MILES RATES ............................. 19 4.0 5.0 DISCUSSION.............................................................................................................. 21 4.1 EFFECT SIZE ................................................................................................... 21 4.2 CONFOUNDING ............................................................................................... 22 4.3 TEMPORAL RELATIONSHIP....................................................................... 23 CONCLUSION ........................................................................................................... 25 vi 5.1 COMPARISON TO OTHER LITERATURE ................................................ 26 5.2 LIMITATIONS .................................................................................................. 27 APPENDIX: SUPPLEMENTARY TABLE ............................................................................. 29 BIBLIOGRAPHY ....................................................................................................................... 32 vii LIST OF TABLES Table 1. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates ......... 10 Table 2. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates ......... 11 Table 3. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates ......... 12 Table 4. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates ......... 13 Table 5. Linear Regression Using Change in Density of On-premise Alcohol Retail per Capita to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates ..................................................................................................................................... 14 Table 6. Linear Regression Using Change in Density of Off-premise Alcohol Retail per Capita to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates ..................................................................................................................................... 14 Table 7. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates 15 Table 8. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Square Mile to Predict Aggravated Assault for 2000 while Controlling for Socio Economic Covariates 16 viii Table 9. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates 17 Table 10. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates ..................................................................................................................................... 18 Table 11. : Linear Regression Using Change in Density of On-premise Alcohol Retail per Square Mile to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates .................................................................................................................... 19 Table 12. Linear Regression Using Change in Density of Off-premise Alcohol Retail per Square Mile to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates .................................................................................................................... 20 Table 13. Basic descriptive statistics for selected demographic characteristics at aggregate county level ............................................................................................................................................... 30 ix LIST OF FIGURES Figure 1. Conceptual Framework Displaying Casual Pathway between Predictors, the Confounder and the Outcome ......................................................................................................... 8 x PREFACE Working on this research has been a great experience and it couldn’t have been done without the guidance and patience of my mentor and advisor Dr. Anthony Fabio. Even when I turned things in late he was always positive and kept me motivated to finish. I would also like to take time to thank my second reader Dr. Tiffany L. Gary-Webb for reading my paper on such short notices and providing great feedback. I wouldn’t have been able to improve this document so drastically without her help. Thank you both for your help and your patience. xi 1.0 INTRODUCTION Violence is not randomly distributed, but tends to cluster in certain neighborhoods with certain characteristics such as high levels of unemployment, low levels of family income, poverty, female headed households and low high school graduations rates – disadvantaged neighborhoods 7-9,27,36 . Ecologic studies at the neighborhood level suggest that availability of alcohol is related to violence, injury, traffic crashes, drunk-driving offenses, cirrhosis mortality, assaultive violence, sexually transmitted diseases and liquor law violations 39 . Violence is intimately linked with alcohol consumption. Studies have shown that “alcohol use directly affects cognitive and physical functions” and can “reduce self-control, the ability to process incoming information, assess risks, increase emotional liability, increase impulsivity, and certain drinkers are more likely to resort to violence in confrontation” 42 . Every year about 3 million violent crimes occur where the offender is perceived to be inebriated. These crimes include rape, sexual assault, robbery, and aggravated and simple assault 8. For years Pennsylvania has been very conservative with alcohol retail with licenses limited based on county populations. State stores owned by the Pennsylvania Control Board were the only places that sold wines and spirits while malt beverages and beer were sold in cases by licensed beer retailors. In 2013 legislature passed which allows for the acquisition of a broader range of alcohol retail license from a wider group of retailers2,3,26. Beer distributors are able to acquire licenses to sell wines, spirits, and six pack beers in addition to the cases of beers which 1 were previously the only thing sold. New areas such as restaurants and supermarkets are now allowed to sell beer and wine. Convenient stores with eat-in areas can also sell take-out beer 51. This increase in alcohol retail has implications for an increase in violence with some studies claiming alcohol outlet density (AOD) as a major contributor to violence while advocating for limiting alcohol outlet density 47,48,49 . For this study, we define AOD as the number of liquor licenses existing within an established geographic area and this includes on-premise alcohol retailers (this includes taverns, nightclubs, hotels and theaters) and off-premise retailers (state liquor stores and beer distributors). One of the main theoretical hypotheses of the association between AOD and violence is the routine activity theory 1,28 . The theory states that a crime occurs when there is an accessible target, the absence of capable guardians (law enforcement) that could intervene and the presence of a motivated offender. It is suggested that areas of high AOD attract motivated offenders, have high rates of accessible targets, and lower rates of capable guardians. This, along with social disorganization theory is thought to decrease social control in areas in which people congregate to purchase alcohol 4,18,36 . Just as areas with high AOD attract motivated offenders, have high rates of accessible targets, and lower rates of capable guardians, areas of high commercial activity exhibit these same traits. Because both of these contribute to an increase in violent crimes and because they are both related to one another it is important to evaluate how model building is affected by the inclusion of commercial activity as a confounder. These theoretical underpinnings are based on the geographic area in which these interactions can occur, in which the location is where the incident took place and relies on accurate measurements and analysis of the neighborhood. 2 There are a number of studies which examine whether AOD within or around a neighborhood is related to higher rates of violence however the results are inconsistent across the studies. Although some studies found an association 13,37,43, many did not find an association 12, 38 or mentioned it would take an unrealistic increase in alcohol retailers to see an effect 44 . There was one study which reported finding an association within univariate models, but not within multivariate models 25. Few studies assessed the temporal association, and limit any assessment of causality. To understand the variations in the current available literature, this study was constructed to assess the following specific aims: 1.) Assess the cross-sectional association with AOD and violence within Pittsburgh during two time periods – 2000 and 2012; 2.) Evaluate the temporal association of alcohol retail density on the incidence of violence as they change over time; 3.) Assess the presence of confounding due to commercial activity and determine the effect size of the results. 3 2.0 METHODS 2.1 DATA SOURCES The sample for this study consisted of 91 well-defined neighborhood tracts with stable boundaries defined by mixture of historical ward boundaries and boundaries decided by the City Planning Commission. Each neighborhood consists of either one or two census tracts. Census tracts have been used as the unit of analysis in previous studies in this area of research 20, and are considered by some to be the most appropriate administrative boundary to use in assessing such neighborhood effects 22 therefore for this study census tracts were used for analysis. The change in geography of census tracts between successive censuses is a major barrier for longitudinal analysis as during each successive census, tracts may be split or consolidated from the previous boundaries. Census tracts boundaries were therefore standardized to the 2000 census. The primary exposure was AOD at the neighborhood level. Part of the study evaluated AOD as a rate calculated by summing the number of establishments within each census tract for each category of alcohol establishment and dividing based on per capita (per 10,000 residents) based on data generated from the US census. Using the same data, AOD rates were also calculated by summing the number of establishments within each census tract for each category of alcohol establishment and dividing based on square miles (per 10 square miles). On-premise outlets were defined as drinking places and included the standard industrial classification (SIC) 4 code of 5183 and off-premise the SIC code of 5181 (wholesale beer) and 5181 (Wholesale wines and distilled alcoholic beverages). Two commercial databases were used, InfoUSA (http://www.infousa.com/) and Dun&Bradstreet (D&B) (http://www.dnb.com/), based on data generated in 2009 and 2003 for Allegheny county, PA to measure and calculate AOD. Details for this process have been described elsewhere 29. InfoUSA and D&B are sales and marketing companies that provide data of businesses in the USA and Canada. In order to standardize the neighborhood boundaries as mentioned above, the Longitudinal Tract Data Base (LTDB) was used, which provides a backwards LTDB in which data provided in 2010 tract boundaries can be estimated within 2000 boundaries (Russel Sage Foundation, 2010). Types of establishments and associated classifications are based on the standard industrial classification and North American Industry Classification (NAICS) taxonomy. The 2000 (the average of the data from 2000 to 2003) and the 2012 (the average of the data from 2009 to 2012) US Census population and demographic data included the number of residents per census tract to calculate density measures (e.g. density of grocery stores within a geographic region) were also used. All establishments were geocoded based on local data provided by the Allegheny County Geographic Information System (GIS) department. The local, reference database included a combination of streets and rooftops, which produce higher match rates and positional accuracy (Roongpiboonsopit and Karimi, 2010). ArcGIS version 10 (ESRI, Redlands, USA) was used to geocode establishments. Spelling sensitivity was set at 70, minimum candidate score at 10 and minimum match score at 60. Output included XY coordinates, which were spatially matched to census tracts using year 2000 government census shape files. The 2003 data was successfully geocode at 87.2% (n = 6,849; 1,008 were unmatched 5 to address points in the geocoding reference file) of the establishments from and 83.1% (n = 3,316; 672 were unmatched) for InfoUSA. The data from 2012 was successfully geocoded at 86.1% (n = 5,073; 817 were unmatched) of the D&B establishments and 84.9% (n = 3,679; 656 were unmatched) from InfoUSA. Neighborhood outcome rates of violence for 2000 and 2012 were calculated from data provided by the Pittsburgh police department. All aggravated assaults and robberies reported to the police are geocoded to a Pittsburgh neighborhood. For police data, definitions were based on the FBI’s Uniform Crime Reporting (UCR) Programs definition. Violent crimes are defined in the UCR Program as those offenses that involve force or threat of force. The primary outcome of interest for this study was aggravated assault as determined by the police report. In the analysis, the neighborhood-level violent crime rate was calculated as crimes per 10,000 persons and per 10 square miles. Finally, data pertaining to 11 neighborhood characteristics were extracted from Summary File 1 and Summary File 3 of the 2000 and 2012 US Census (US Census Bureau, 2003). These variables were chosen as they had been used in previous studies of alcohol availability and violent crime 11, 22, 24 , as well as studies of violent crime in urban neighborhoods7-10, 43. These data included racial composition (total population that was non-White), total population size, sex (total population that was male), unemployment (total population 16 years and over in labor force who were unemployed), median family income, median home income, poverty (percentage of households who made an income below the poverty level in 1999 and percentage of households with public assistance income), family instability (percentage of female-headed households), and education (percentage of the population older than 25 years with at least a high school diploma and percentage of the population older than 25 years with a Bachelor's degree). 6 2.2 DATA ANALYSIS All analyses were conducted using SAS 9.4 and began with summary and descriptive statistics which can be found in Table 1. Initially the data was acquired as counts, but were transformed to rates for analysis. In order to evaluate the differences between 2000 and 2012 two techniques were executed: first, cross-sectional models were created for the two time periods; second, change variables were created by taking the difference between 2012 and 2000 for each predictor and from these predictors linear regression models were created. For the cross-sectional models, negative binomial regression with a log link was used in order to protect against the effect of excessive zeroes in the data. Following the example of previous studies, backward stepwise selection regression was used to remove variables that did not fit a predetermined pvalue of <0.2; the predictor of interest remained in the model regardless of its p-value and was controlled for by 11 demographic variables which were mentioned previously 5,43. It was suspected that there was some confounding with the increase in commercial activity in Pittsburgh so after final models were built; the covariate “restaurant outlet density” was added to the model to check for the robustness of the predictor of interest 45 . It was suspected that if the Routine Activities Theory is taken into account the increase in commercial activity fits well for explaining the presence of crime in many areas of Pittsburgh as focus on infrastructure is encouraging growth in commercial activity 1, 28. With this in mind, the presence of AOD is expected to increase in areas where commercial activity has increased and along with this, likely offenders are presented with suitable targets in areas where people are more likely to congregate. 7 As mentioned previously, change variables were calculated by subtracting their 2000 values from their 2012 values; the change for the outcome of interest was also calculated in the same way and backward stepwise selection linear regression was used. After the final models were produced influential points were identified using Cook’s distance 21, 46 . Each identified point was considered for removal and if removed was replaced with a missing value. This was done one influential point at a time stepwise between each replacement. Two census tracts were highly influential and were determined to be mostly commercialized with little to no residential areas and thus were different from the other neighborhoods in the data set; because of this they were removed from the model so that the data was reflected in a more accurate way 21 . After influential points were removed, models were created again using backward stepwise selection regression starting from the full model. 2.3 CONCEPTUAL FRAMEWORK Alcohol Outlet Density Commercial Activity Aggravated Assault Demographic Variables Figure 1. Conceptual Framework Displaying Casual Pathway between Predictors, the Confounder and the Outcome 8 3.0 RESULTS There were 91 tracts in this study for which summery statistics were generated as seen in Table 1. The average population across all tracts was 3,717 in 2000 and 3,405 in 2012. There was an increase in median family and home income from 2000 to 2012, which indicates positive economic development across all census tracts. The number of high school graduates and population with at least a bachelor’s degree increased slightly from 2000 to 2012. The mean total population using public assistance income decreased from 211 in 2000 to 178 in 2012. The average total population below the poverty level decreased from 560 in 2000 to 521 in 2012. Unemployment also decreased from 180 in 2000 to 166 in 2012. The average on-premise AOD increased from 2000 to 2012 (31 to 40). Once rates were created by dividing per square miles there were differences in the average on-premise AOD which decreased slightly from 2000 to 2012 (16 to 10). The average and minimum off-premise alcohol retail density decreased, but not significantly from 2000 to 2012 and the maximum decreased slightly from 23 to 16. 3.1 MODELS FOR POPULATION RATES 2000 The negative binomial regression model for predicting aggravated assault in 2000 revealed that on-premise alcohol retail density (β= 0.0062; p-value< 0.0001), female headed households (β= 0.0243; p-value= 0.0016), having an income below the poverty level (β= 9 0.0258; p-value= 0.0003) and households on public assistance (β= 0.0961; p-value< 0.0001) are all significant predictors. The predictor of interest was significant before restaurant density was added to the model, but became not significant after it was added to the model (β= 0.0021; pvalue< 0.2006). Table 1. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates Model for On-Premise Restaurant Outlet Density Added with On-Premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 3.1245 <0.0001 2.9297 <0.0001 Density of On-Premise Alcohol Establishments 0.0062 <0.0001 0.0021 0.2006 Female householder, No Husband Present (%) 0.0243 0.0016 0.0410 <0.0001 Income Below Poverty Level (%) -0.0258 0.0003 -0.0060 0.4557 Households with Public Assistance Income (%) 0.0961 <0.0001 0.0183 0.3737 Restaurant Establishment - - 0.0020 <0.0001 The negative binomial regression model for predicting aggravated assault in 2000 revealed that off-premise alcohol retail density (β= 0.0207; p-value< 0.0001), total population (β= -0.0002; p-value< 0.0001), population which identify as black (β= -0.0002; p-value= 0.0019), having an income below the poverty level (β= -0.0206; p-value= 0.0033) and households on public assistance (β= 0.0722; p-value< 0.0001) are all significant predictors. The 10 predictor of interest was significant before restaurant density was added to the model, but became not significant after it was added to the model (β= -0.0031; p-value< 0.6352). Table 2. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates Model for OffPremise Restaurant Outlet Density Added with Off-Premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 4.2017 <0.0001 3.9372 <0.0001 Density of Off-Premise Alcohol Establishments 0.0207 <0.0001 -0.0031 0.6352 Total Population -0.0002 <0.0001 -0.0001 <0.0001 Black or African American Alone 0.0002 0.0019 0.0003 <0.0001 Income Below Poverty Level (%) -0.0206 0.0033 0.0017 0.8251 Households with Public Assistance Income (%) 0.0722 <0.0001 0.0155 0.3584 Restaurant Establishment - - 0.0017 <0.0001 3.2 MODELS FOR POPULATION RATES 2012 The negative binomial regression model for predicting aggravated assault in 2012 revealed that on-premise alcohol retail density (β= 0.0044; p-value< 0.0001), total population (β= -0.0001; p-value< 0.0001), population which identify as black (β= 0.0003; p-value= 0.0009), female headed households (β= -0.0317; p-value= 0.0223), having an income below the poverty level (β= 0.0161; p-value= 0.0414) and households on public assistance (β= 0.0529; p-value= 11 0.0114) are all significant predictors. The predictor of interest was significant before and after restaurant density was added to the model (β= -0.0019; p-value= 0.0243). Table 3. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates Model for On-Premise Restaurant Outlet Density Added with On-Premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 3.9644 <0.0001 3.7157 <0.0001 Density of On-Premise Alcohol Establishments 0.0044 <0.0001 -0.0019 0.0243 Total Population -0.0001 <0.0001 -0.0001 <0.0001 Black or African American Alone 0.0003 0.0009 0.0003 <0.0001 Female householder, No Husband Present (%) -0.0317 0.0223 -0.0231 0.0410 Income Below Poverty Level (%) 0.0161 0.0414 0.0165 0.0088 Households with Public Assistance Income (%) 0.0529 0.0114 0.0477 0.0041 Restaurant Establishments - - 0.0025 <0.0001 The negative binomial regression model for predicting aggravated assault in 2012 revealed that off-premise alcohol retail density (β= 0.0188; p-value< 0.0001), total population (β= -0.0002; p-value< 0.0001), population which identify as black (β= 0.0003; p-value= 0.0017), female headed households (β= -0.0331; p-value= 0.0228) and households on public assistance (β= 0.0494; p-value= 0.0259) are all significant predictors. The predictor of interest was 12 significant before and after restaurant density was added to the model (β= -0.0224; p-value= 0.0001). Table 4. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Capita to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates Model for OffPremise Restaurant Outlet Density Added with Off-Premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 4.2735 <0.0001 3.6011 <0.0001 Density of Off-Premise Alcohol Establishments 0.0188 <0.0001 -0.0224 <0.0001 Total Population -0.0002 <0.0001 -0.0001 <0.0001 Black or African American Alone 0.0003 0.0017 0.0003 <0.0001 Female householder, No Husband Present (%) -0.0331 0.0228 -0.0224 0.0332 Income Below Poverty Level (%) 0.0129 0.1174 0.0189 0.0015 Households with Public Assistance Income (%) 0.0494 0.0259 0.0477 0.0020 Restaurant Establishments - - 0.0030 <0.0001 3.3 MODELS FOR CHANGE IN POPULATION RATES From the linear regression models, the values for on-premise and off-premise alcohol retail density were not significant with values β= 0.03761, p-value= 0.8311 and β= 1.87664, pvalue= 0.0893 respectively. In regards to the temporal relationship between the predictors and 13 the outcome, these values indicate that there is no significant association between the change in the predictors of interest and the change in the outcome. Table 5. Linear Regression Using Change in Density of On-premise Alcohol Retail per Capita to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates Variable Estimate (β) P Value Intercept -2.03949 0.7517 Change in Density of On-Premise Alcohol Establishments 0.03761 0.8311 Change in Total Population -0.01227 0.1931 Change in Black or African American Alone 0.01251 0.1805 Change in Female householder, No Husband Present (%) -0.98752 0.1457 Change in Population 25 years and over who are High School Graduate or more (%) 0.94768 0.0413 Change in Population 25 Years and Over with Bachelor's Degree (%) -1.29794 0.1042 Table 6. Linear Regression Using Change in Density of Off-premise Alcohol Retail per Capita to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates Variable Estimate (β) P Value Intercept 1.9438 0.7426 Change in Density of Off-Premise Alcohol Establishments 1.87664 0.0893 Change in Population 25 years and over who are High School Graduate or more (%) 1.15797 0.0062 Change in Population 25 Years and Over with Bachelor's Degree (%) -1.06289 0.1538 14 3.4 MODELS FOR SQUARE MILES RATES 2000 The negative binomial regression model for predicting aggravated assault in 2000 revealed that on-premise alcohol retail density (β= 0.0138; p-value= 0.0002), total population (β= -0.0002; p-value< 0.0001), population which identify as black (β= 0.0002; p-value= 0.0145), population over 16 years old who are unemployed (β= -0.0007; p-value= 0.0588 [marginally significant]), population who at least hold a high school diploma (β= 0.0296; p-value= 0.0008) and households on public assistance (β= 0.0670; p-value< 0.0001) are all significant predictors. The predictor of interest was significant before restaurant density was added to the model, but became not significant after it was added to the model (β= 0.0034; p-value= 0.2037). Table 7. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2000 while Controlling for Socio Economic Covariates Model for On-premise Restaurant Outlet Density Added with On-premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 1.6801 0.0285 5.1259 <0.0001 Density of On-premise Alcohol Establishments (per square mile) 0.0138 0.0002 0.0034 0.2037 Total Population -0.0002 <0.0001 -0.0001 <0.0001 Black or African American Alone 0.0002 0.0145 0.0003 <0.0001 Population 16 Years and Older Unemployed -0.0007 0.0588 -0.0003 0.3063 Populations 25 years and over whom are High School Graduate or more (%) 0.0296 0.0008 -0.0149 0.1414 Households with Public Assistance Income (%) 0.0670 <0.0001 0.0096 0.4638 Restaurant Establishment - - 0.0017 <0.0001 15 The binomial regression model for predicting aggravated assault in 2000 revealed that off-premise alcohol retail density (β= 0.0672; p-value= 0.0049), total population (β= -0.0002; pvalue< 0.0001), population which identify as black (β= 0.0002; p-value= 0.0158), population who at least hold a high school diploma (β= 0.0242; p-value= 0.0055) and households on public assistance (β= 0.0592; p-value< 0.0001) are all significant predictors The predictor of interest was significant before restaurant density was added to the model, but became not significant after it was added to the model (β= 0.0098; p-value= 0.5393). Table 8. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Square Mile to Predict Aggravated Assault for 2000 while Controlling for Socio Economic Covariates Model for Off-premise Restaurant Outlet Density Added with Off-premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 2.2586 0.0029 5.4030 <0.0001 Density of Off-premise Alcohol Establishments 0.0672 0.0049 0.0098 0.5393 Total Population -0.0002 <0.0001 -0.0001 <0.0001 Black or African American Alone 0.0002 0.0158 0.0003 <0.0001 Population 16 Years and Older Unemployed -0.0007 0.0676 -0.0003 0.3417 Populations 25 years and over whom are High School Graduate or more (%) 0.0242 0.0055 -0.0181 0.0646 Households with Public Assistance Income (%) 0.0592 <0.0001 0.0061 0.6306 Restaurant Establishment - - 0.0018 <0.0001 16 3.5 MODELS FOR SQUARE MILES RATES 2012 The negative binomial regression model for predicting aggravated assault in 2012 revealed that on-premise alcohol retail density (β= 0.0317; p-value< 0.0001), total population (β= -0.0002; p-value< 0.0001), population which identify as black (β= 0.0002; p-value= 0.0236), population who hold a bachelor’s degree (β= -0.0435; p-value< 0.0001) and households on public assistance (β= 0.0570; p-value= 0.0151) are all significant predictors. The predictor of interest was significant before restaurant density was added to the model and remained significant after restaurant was added to the model (β= 0.0107; p-value= 0.0104). Table 9. Negative Binomial Regression Using Density of On-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates Model for On-premise Restaurant Outlet Density Added with On-premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 3.6914 0.0008 3.8567 <0.0001 Density of On-premise Alcohol Establishments 0.0317 <0.0001 0.0107 0.0104 Total Population -0.0002 <0.0001 -0.0002 <0.0001 Black or African American Alone 0.0002 0.0236 0.0003 0.0017 Female householder, No Husband Present (%) -0.0277 0.0749 -0.0078 0.5070 Populations 25 years and over whom are High School Graduate or more (%) 0.0169 0.1162 0.0034 0.7232 Total Population 25 Years and Over with Bachelor's Degree -0.0435 <0.0001 -0.0159 0.1075 Households with Public Assistance Income (%) 0.0570 0.0151 0.0485 0.0034 Restaurant Establishments - - 0.0014 <0.0001 17 The negative binomial regression model for predicting aggravated assault in 2012 revealed that off-premise alcohol retail density (β= 0.1167; p-value= 0.0023), total population (β= -0.0003; p-value< 0.0001), population which identify as black (β= 0.0003; p-value= 0.0364), female headed households (β= -0.0371; p-value= 0.0222), population who hold a bachelor’s degree (β= -0.0438; p-value< 0.0001) and households on public assistance (β= 0.0581; p-value= 0.0245) are all significant predictors. The predictor of interest was significant before restaurant density was added to the model, but became not significant after it was added to the model (β= 0.0192; p-value= 0.4625). Table 10. Negative Binomial Regression Using Density of Off-premise Alcohol Retail per Square Mile to Predict Aggravated Assault in 2012 while Controlling for Socio Economic Covariates Model for Offpremise Restaurant Outlet Density Added with Off-premise Variable Estimate (β) P Value Estimate (β) P Value Intercept 4.2118 0.0003 4.0724 <0.0001 Density of Off-premise Alcohol Establishments 0.1167 0.0023 0.0192 0.4625 Total Population -0.0003 <0.0001 -0.0002 <0.0001 Black or African American Alone 0.0003 0.0364 0.0003 0.0045 Female householder, No Husband Present (%) -0.0371 0.0222 -0.0087 0.4710 Populations 25 years and over whom are High School Graduate or more (%) 0.0155 0.1714 0.0009 0.9262 Total Population 25 Years and Over with Bachelor's Degree -0.0438 <0.0001 -0.0122 0.2339 Households with Public Assistance Income (%) 0.0581 0.0245 0.0476 0.0056 Restaurant Establishments - - 0.0016 <0.0001 18 3.6 MODELS FOR CHANGE IN SQUARE MILES RATES The values produced from the linear regression models show that both on-premise and off-premise alcohol retail density were not significant with values β= 0.32286, p-value= 0.2017 and β= 2.47946; p-value= 0.1075 respectively. Exactly like the models created using the percapita data, the values in the next two tables indicate that there is no significant association between the change in the predictors of interest and the change in the outcome. Table 11. Linear Regression Using Change in Density of On-premise Alcohol Retail per Square Mile to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates Variable Estimate (β) P Value Intercept -0.98213 0.8761 Change in Density of On-premise Alcohol Establishments 0.32286 0.2017 Change in Total Population -0.01263 0.1745 Change in Black or African American Alone 0.01154 0.2123 Change in Female householder, No Husband Present (%) -0.94901 0.1561 Change in Population 25 years and over who are High School Graduate or more (%) 1.00769 0.0272 Change in Population 25 Years and Over with Bachelor's Degree (%) -1.31914 0.0954 19 Table 12. Linear Regression Using Change in Density of Off-premise Alcohol Retail per Square Mile to Predict Change in Aggravated Assault while Controlling for the Change in Socio Economic Covariates Variable Estimate (β) P Value Intercept -0.30326 0.9616 Change in Density of Off-premise Alcohol Establishments 2.47946 0.1075 Change in Total Population -0.01410 0.1301 Change in Black or African American Alone 0.01138 0.2156 Change in Female householder, No Husband Present (%) -0.93249 0.1609 Change in Population 25 years and over who are High School Graduate or more (%) 0.96243 0.0322 Change in Population 25 Years and Over with Bachelor's Degree (%) -1.30389 0.0971 20 4.0 DISCUSSION 4.1 EFFECT SIZE Of the studies found during the literature review there were only 5 which reported an effect size 12,25,37,43,44 . Of those five, three used R2 as their measure while the other two used relative risk and Akaike information criterion (AIC). Of the different methods used to describe the effect size, the most useful measure is relative risk because R2 and AIC are not real measures of effect since they only describe how much variability in the outcome is predicted by the model. R2 and AIC don’t describe the magnitude of the relationship between the predictor(s) of interest and the outcome. Relative risk however is a well-documented method for measuring the magnitude of an association between an exposed and non-exposed group 52-56. For comparison reasons, relative risk (RR) was calculated for the predictors of interest by exponentiation of their beta values (exponential formula being eβ). From this study’s population based rates in 2000 it was found that the RR of aggravated assault occurring in an area with on-premise outlet density was 1.006 which indicates that there is almost no association. After commercial activity was added to the model the predictor of interest became not significant. This result indicates that when not taking the confounding factor into consideration, the effect of AOD in an area does not have a meaningful effect. 21 Similar results were found for all models in 2000 where the largest relative risk was 1.069 from the off-premise model for square mile rates. This result indicates that an area with off-premise AOD would have an approximately 7% higher risk of aggravated assaults than an area without AOD. Even as the largest relative risk value, the magnitude of this effect is not very large and once adjusted for commercial activity became non-significant. In 2012, the largest relative risk was 1.124 from the off-premise model for square mile rates. This indicates that an area with off-premise AOD would have a 12% higher risk of aggravated assault than an area without AOD. This value might indicate a meaningful effect depending on how risky a safe neighborhood is expected to be. With that said, after adding commercial activity to the model this value is no longer significant. Compared to the paper with relative risk, this result appears to be consistent as Zhu Li, et al. found similar results in their paper and concluded that alcohol outlet density is not strongly associated with violent crime, but rather activity around illicit drug markets presents a much stronger association 44. 4.2 CONFOUNDING As with previous studies the results from this study show positive associations when commercial activity is initially ignored. However, taking into account a potential confounder had a major impact on the results. The results discussed in the previous section briefly describes some of the effects of adjusting for commercial activity as a potential confounder on the results with many of the models showing AOD as significant before commercial activity is included, but not significant once commercial activity is included. In 2000 the results of the all the models 22 whether they are based on population rates or square mile rates - show that once commercial activity is adjusted for, AOD is not a significant predictor for aggravated assault. In 2012 the potential confounding affects the results in a different way. Every model in 2012 (except one) remains significant and showed a positive association before adding restaurants to the models, but the models for population rates showed a change in the direction of association once commercial activity was adjusted for. Possible confounding in the 2000 data was confirmed when the predictors of interest changed from significant to non-significant; in 2012 instead of a change in significance, there were changes in direction of association. These changes all seem to confirm that commercial activity was a potential confounder. Many previous studies found a positive association between AOD and violence, but failed to take any confounding factors into consideration. It is possible that other potential confounders exist and should be considered for model building. 4.3 TEMPORAL RELATIONSHIP To understand the temporal relationship of AOD it was important to evaluate the change in AOD as it related to the change in aggravated assault while controlling for the change in other factors. During the linear model building process, change in AOD remained non-significant. What was found was that as AOD changed over time, it did not significantly influence the change in aggravated assault over time as the p-value remained greater than 0.05. This is important to note since as mentioned previously some studies suggested that reducing AOD will reduce violence rates in an area over time. Based on the comparison of results from the cross sectional portion of this study to the temporal portion, cross sectional models are not fair 23 assessments of AODs effect on violence over time as there may be a significant positive association within every time period, but using a change over time model it’s possible that those same studies would find that those associations aren’t significantly related to a change in violence over time. With that said, showing cross-sectional analysis of the association of AOD on violence is not enough to make a decision about reducing violence over crime by reducing AOD. 24 5.0 CONCLUSION Although there are many studies that concluded that there is an association between AOD and violence, this study was not able to find a significant association. Three key aspects were discussed: effect size, potential confounding and the temporal relationship between AOD and violence. Looking at effect size, it was noted that the majority of risk ratios were approximately equal to 1 which indicates that there is approximately no association between AOD and violence. Even if the models produced larger relative risk values, the majority of models produced a predictor of interest that was no longer significant once commercial activity was added to the model. With this in mind it might be possible that there are other confounding factors that were unaccounted for or that may be present in other areas that are not present in Pittsburgh and vice versa. For example, commercial activity might not act as a confounder in more rural areas where AOD is present. Future studies should try to consider the possibility of confounding and adjust for it. The reporting of effect size in a standardized way is also important. It was difficult to compare the effect size found in this study with other studies because the majority used Rsquared which is not a very useful indicator of effect size. There was only one study that reported relative risk which is a great indicator. This study could have gone further by comparing the effect sizes found here to other studies in order to assess how much of an impact AOD has on violence, but with the current information available this task may be conducted in the future. 25 Another important study design future papers should consider is the temporal relationship of AOD on violence. There were only a few papers that took the temporal relationship into consideration. As policy aimed at reducing violence is developed, it is important to guide decisions using the results of research. As it stands, most research provides cross sectional results which isn’t as useful as temporal results such as those produced from models containing change variables. It might be possible to reduce violence from alcohol consumption in a more fruitful way if future research also concluded that AOD is not a major contributor. As AOD increases in Pittsburgh the results of this study may change in the future, but this study must conclude that it is not significantly nor practically related to aggravated assault. 5.1 COMPARISON TO OTHER LITERATURE Previous studies applied various model building methods to evaluate the effects of alcohol density on violence. Many focused on the geographic association of violence and the environmental context that drinking occurred in such as demographic factors and types of alcohol retail establishments. The common theme shared within the literature was the evaluation of the spatial relationship between AOD and violence. The conclusion of these research varied depending on what other factors were considered as the data was evaluated. In the Brower et al. paper, the relationship between the congregation of students and the time of day was considered for evaluation 57. In the paper by Graham et al. they looked at sexual activity and bar location as it factored into the relationship between AOD and violence 14. Zhu et al. looked at the association between illicit drug markets and violence and compared that to AOD and violence 44. What most 26 of these papers concluded is that other factors play a larger role in the incidence of violent activity than alcohol outlet density. For instance, Graham et al. found that aggression was more severe at suburban locations rather than locations where there was a lot of entertainment such as clubs and bars (commercial activity). Comparing this result to the results of this paper, it appears that social constructs in an area do indeed influence the way AOD relates to violence. In this research we evaluated commercial activity as a potential confounder and believe that although it’s not a direct confirmation, this research supports their findings that areas where there are entertainment such as clubs, bars or restaurants (commercial activities) there is an interaction between those and AOD which simultaneously impact violence. 5.2 LIMITATIONS There were several study limitations. Population density and square miles were not evenly distributed and so some areas had more of an influence on the outcome than others. There are some areas in Pittsburgh that have almost no residential areas and so for model building two of those areas were removed. The points removed were not only influential points with a lot of leverage; they were also areas with no residential areas, but a lot of alcohol outlet retail and commercial activity. The approach to interpreting the longitudinal effect of AOD on violence was also a major limitation. Actual longitudinal data was not used for model building so instead the difference between the two years was taken and modeled. The use of change variables can only act as a slight description of the temporal relationship between AOD and violence. It tells us that there is no significant association between the change in the predictor as it relates to the change in the outcome. If there was a significant association, it would be impossible to describe 27 what the change meant; as AOD increased we wouldn’t be able to tell if violence increased or decreased – we would only be able to say that it changed over time along with AOD. 28 APPENDIX: SUPPLEMENTARY TABLE 29 Table 13. Basic descriptive statistics for selected demographic characteristics at aggregate county level 2000 2012 Change Variable Min Max Mean SD Min Max Mean SD Min Max Mean SD Median Household Income 7,440 642,660 12,1117 13,3326 9,375 831,268 160,701 17,5017 24,5901 38,306 57,982 Median Family Income 0 991,320 161,323 187,538 10,148 1,524,784 234,268 290,686 14,7422 -34,213 752,168 69,406 121,263 Populations 25 years and over whom are High School Graduate or more (%) 28 100 78 11 0 100 87 13 -100 72 8 17 Total Populations 25 years and over whom are High School Graduate or more 20 13,489 3,017 2,924 0 14,426 3,053 3,070 -712 1,776 36 475 Population 25 Years and Over with Bachelor's Degree (%) 0 34 11 7 0 49 15 9 -20 24 3 6 Total Population 25 Years and Over with Bachelor's Degree 0 4,097 508 765 0 4,671 598 834 -566 863 90 211 Total Population 41 14,507 3,717 3,272 0 14,826 3,405 3,247 -1,418 1,117 -313 488 Male Population 20 6,923 1,768 1,607 0 7,340 1,636 1,622 -848 1,119 -132 308 Black or African American Alone 1 4,980 1,008 1,193 0 4,368 876 937 -1,640 1,419 -132 516 Households with Public Assistance Income (%) 0 57 8 9 0 36 7 8 -57 30 1 9 Total Households with Public Assistance Income 0 917 211 191 0 607 178 167 -430 272 -33 125 Income Below Poverty Level (%) 0 100 19 18 0 100 19 18 -100 92 0.1746 18 Total with Income Below Poverty Level 0 1,967 560 492 0 1,967 521 486 -1417 1182 -39 364 30 Table 13 continued Population 16 Years and Older Unemployed 0 2,283 180 294 0 591 166 146 -1880 385 -14 250 Female householder, No Husband Present (%) 2 71 20 13 0 71 18 14 -37 29 -2 8 Total Female householder, No Husband Present 5 2,154 634 518 0 1,725 502 448 -974 364 -133 230 Density of On-Premise Alcohol Establishments (per capita) 0 902 31 100 0 2,105 40 227 -472 2,105 8 231 Density of Off-Premise Alcohol Establishments (per capita) 0 150 5 16 0 263 5 29 -68 263 0.5660 29 Density of On Premise Alcohol Establishments (per square mile) 0 227 16 32 0 142 10 21 .93 36 -6 17 Density of Off Premise Alcohol Establishments (per square mile) 0 23 3 5 0 16 2 3 -11 6 -1 3 Total Restaurant Establishments 0 2,068 100 317 0 2,857 106 400 - - - - 31 BIBLIOGRAPHY 1. 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