Linking Consumer 1 Running head: LINKING TOGETHER CONSUMER KNOWLEDGE Linking Together Consumer Knowledge and the Effects of Caffeine on Performance Estella E. Nelson & Amanda L. Taylor Northwest Arkansas Community College Linking Consumer 2 Abstract This study was conducted to evaluate the knowledge, beliefs, and behaviors of physically active consumers in regard to effects of caffeine intake during performance. A survey was conducted to identify the behaviors and beliefs of consumers. The study surveyed active and very active individuals from local health clubs and university athletic departments. Fifty surveys were completed and percentages from responses were calculated. Caffeine is a xanthine alkaloid compound found in coffee, tea, guarana, and cocoa. Many food, beverage and dietary supplement products are formulated, marketed, and purchased that contain caffeine. The survey conclude that 94% of physically active consumers ages 18-52 consume coffee, soda beverages, tea, energy drinks, and energy tablets. Sixty-four percent of the consumers believe that caffeine affects performance, 52% believe that caffeine enhances performance, yet only 32% of consumers caffeinate prior to exercise. The pharmacodynamics and the pharmacokinetics of caffeine are reviewed in light of the survey findings. The surveys found that only 4 % respondents knew the amount of caffeine in milligrams they consumed. Studies have shown that caffeine does affect performance, in that it enhances endurance. Interestingly, survey results showed that 52% of the physically active consumers believe that caffeine enhances performance while 14% believe that it decreases performance and 26% believe that caffeine did neither. Linking Consumer 3 An Overview of Caffeine Caffeine is a central nervous system and metabolic stimulant. It inhibits phosphodiesterase and has an antagonistic effect on central adenosine receptors (Reynolds, 1989). Its effect on the central nervous system produces a condition of wakefulness and increased mental activity (Reynolds, 1989). The major sources of caffeine in the adult diet in North America are coffee (6075%) and tea (15-30%). Caffeinated soft drinks and chocolate are the major sources in the diets of children (Nawrot, Jordan, Eastwood, Rotstein, Hugenholtz, Feeley 2003). While not everyone likes coffee, tea, and colas, some turn to energy drinks. Some energy drinks listed on surveys were Sobe No Fear, Rock Star, Enviga, N O Explode, and Ripped To The Max. With caffeine being so frequently ingested in foods, beverages, supplements, and medications it is considered the most widely consumed psychoactive "drug" in the world and probably one of the most commonly used stimulants in sports. (Magkos & Kavouras 2005) Also, caffeine may be administered in powder or tablets in doses of 100 – 300 mg as in aspirin and other analgesics. The International Olympic Committee has banned the use of large amounts of caffeine by athletes, however smaller doses, as those found in common coffee and soda beverages are permitted. The maximum permission concentration of caffeine in urine is 12μg per mL (Martindale1989). Chart 1 lists many common beverages and their approximate amounts of milligrams per serving. Chart 2 describes the products used, the amount used, when, and their knowledge of milligrams, by the consumers surveyed. Chart 1: Commonly used products containing caffeine. Caffeine content of select common food and drugs[42][43] Product Caffeine tablet Excedrin Serving size Caffeine per serving (mg) 1 tablet 200 1 tablet 65 Linking Consumer 4 tablet Coffee, brewed 240 mL (8 U.S. fl oz) 135* Coffee, decaffeinat 240 mL (8 U.S. fl oz) ed Coffee, espresso 57 mL (2 U.S. fl oz) 5* 100* Chocolate, Dark (Hershey's 1 bar (43 g; 1.5 oz) Special Dark) 31 Chocolate, Milk (Hershey Bar) 1 bar (43 g; 1.5 oz) 10 Red Bull 250 mL (8.2 U.S. fl oz) 80 Cocaine Energy Drink 30 mL (1 U.S. fl oz) 100 250 mL (8.4 U.S. fl oz) 280 Rockstar Energy Linking Consumer 5 Drink Jolt Cola 29.57 mL (1 U.S. fl oz) 100 Bawls Guarana 750 ml (1 bottle) 280 Soft drink, Mountain 1 chocolate Dew "Dew 100 Fuel" Soft drink, Coca-Cola 355 mL (12 U.S. fl oz) 54.5 Classic Tea, green 255 mL (7 U.S. fl oz) 100 Tea, leaf or bag 240 mL (8 U.S. fl oz) 15* * Estimated average caffeine content per serving. Actual content varies according to preparation 240 mL (8 U.S. fl oz) 50* Source: www.wikipedia.com Linking Consumer 6 Chart 2: Products consumed. Product Coffee Soda Beverage Tea Energy Drink Energy Tablet % of participants (some may use multiple products) 28% 58% 34% 20% 4% 2+/day users consume prior exercise participants that knew milligrams of caffeine 7 participants 7 participants 6 participants 1 participant 1 participant 7 participants 11 participants 4 participants 7 participants 1 participant 1 participant 1 participant 1 participant For individuals that are sensitive, caffeine in small amounts, such as a cup of coffee, may cause nervousness and insomnia(Martindale1989) . Higher doses of caffeine may cause medullary stimulation and convulsions (Martindale1989). The chemical structure of caffeine is shown in Diagram 1. Other names for caffeine are anhydrous caffeine, caffeine, caffeinum, guaranine, methylxanthines, methytheobromine, and theine. Diagram 1: The chemical structure of caffeine. C8H10N4O2 Source: www.wikipedia.com Linking Consumer 7 Pharmacokinetics Caffeine is absorbed readily after oral, rectal, parental administration, and through the skin (Schonwald 2001) . It is absorbed from the gastrointestinal tract and peak plasma levels occur in 45 minutes to 2 hours (Schonwald 2001). Caffeine is then distributed rapidly into body water with an apparent volume of distribution of 1L/kg. (Schonwald 2001) The liver metabolizes caffeine to 3,7-theobromine, 1,3-theophyllline, and 1,7paraxanthine(Martindale1989) . These are metabolites of dimethylxanthines (Martindale1989). Diagram 2 shows the chemical structures of the three primary metabolites. Caffeine is excreted in urine, saliva, semen, and breast milk (Martindale1989). The half-life (the time for the body to eliminate one half of the total amount of caffeine consumed at a given time) of caffeine in normal adults is 3.0 to 7.5 hours (Schonwald 2001). Diagram 2: Structure of the three primary metabolites. Source: www.wikipedia.com Pharmacodynamics The methylxanthines have effects on the central nervous system, kidney, and cardiac and skeletal muscle as well as smooth muscle (Martindale1989). Caffeine acts as a stimulant towards the central nervous system (Martindale1989). It inhibits the enzyme phophodiesterase and has an antagonistic effect at central adenosine receptors (Martindale 1989) Caffeine is a ligand (a molecule that binds specifically to a receptor site of another cell) that binds to surface cells of adenosine receptors without activating Linking Consumer 8 them (Katzung 1995). This reduces adenosine activity and increases the activity of the neurotransmitter dopamine, which accounts for the stimulatory effect (Katzung 1995). The methylxanthines have direct positive chronotropic and inotropic effects (cardiovascular effects) on the heart (Katzung 1995). In unusually sensitive people consuming a few cups of coffee may result in arrhythmias, but in most people, consumption of higher doses of methylxanthines produces only sinus tachycardia and increased cardiac output (Katzung 1995). . The methylxanthines affect the gastrointestinal tract in that it stimulates secretion of both gastric acid and digestive enzymes (Katzung 1995). The kidneys are especially affected by theophylline as it is a weak diuretic (Katzung 1995). However, the diuresis is not sufficient to be therapeutic (Katzung 1995). Methylxanthines produce bronchodialation and is considered the major therapeutic action (Katzung 1995). Other therapeutic actions of methylxanthines are strengthening the contractions of isolated skeletal muscle in vitro and having potential effects in improving contractibility and in reversing fatigue of the diaphragm in patients with chronic obstructive lung diseases (Katzung 1995). Caffeine and Exercise Performance Caffeine is a naturally occurring substance ingested in a variety of forms, and produces many hormonal, metabolic, and physiological effects throughout the body, both at rest and during exercise (Magkos & Kavours 2005). It has been studied for its use as a potential use as an ergogenic (increasing the capacity for mental and physical labor) aid (Keisler & Armsey 2006). Several studies have demonstrated an improvement in exercise performance in submaximal endurance activities (Keisler & Armsey 2006). However, in high-intensity exercises, its potential ergogenic effect in acute, high intensity exercise is unclear. Because of its potential use as an ergogenic aid, its use in sports is regulated by most sanctioning bodies (Keisler & Armsey 2006). When evaluating the effects of caffeine on individuals’ physiology and performance, it is important to consider whether subjects are caffeine naïve or caffeine tolerant (Reents 2000). In naïve subjects, caffeine increases epinephrine output in proportion to dose (Reents 2000). Graham, Hibbert, and Sathasivam (1998) recently found that caffeine ingested as capsules improved treadmill running by 31% compared to placebo. When subjects ingested the caffeine from coffee, however, no increase in performance was seen, despite a similar caffeine dose and equivalent caffeine plasma concentrations” (Reents 2000). Other researchers have studied specific activities in regards to caffeine consumption. Berglund and Hemmingsson (1982) studied cross-country skiing and found skiers ingesting 6mg/kg produced 1.7% improvement at an altitude of 300 m and a 3.2% improvement in performance at 2900 m. Another study (Spriet et al. 1992) of cyclists, single doses of 9 mg/kg caffeine consumed 1 hour prior to testing produced a 26.9% increase in cycling time in recreational cyclists (Reents 2000). Caffeine appears to offer ergogenic effects in prolonged endurance exercise but not during activities that require very short bursts of high-intensity effort (Reents 2000). For reasons that are unclear, caffeine consumed in capsules appears to Linking Consumer 9 produce a greater ergogenic response that equal quantities consumed in coffee (Reents 2000). A more recent study (Stuart, Hopkins, Cood, & Cairns 2005) investigating effects of caffeine in a performance test stimulating physical and skill demands of a rugby union game. The conclusion was that caffeine was likely to produce substantial enhancement of several aspects of high-intensity team sport performance (Stuart, Hopkins, Cood, & Cairns 2005). The results of caffeine ingestion “preloaded’ protocol involving 2 minute cycling at 100% plus 1 minute of ‘all-out’ effort suggest that high intensity cycling performance can be increased following moderate caffeine ingestion and that this improvement may be related to a reduction in RPE and an elevation in blood lactate concentration (Doherty, Smith, Hughes, Davison 2004). Nancy Clark states, “Caffeine’s energy-enhancing effect is more likely related to its ability to make exercise seem easier. Through its stimulant effect upon the brain, caffeine may reduce the fatigue associated with long bouts of exercise. If you are chronically tired from the rigors of your training program, you may be particularly attracted to caffeine for this reduction in perceived exertion" (Clark 2003). Author of Popular Sports Supplements and Ergogenic Aids, Mark S. Juhn (2003) writes: Generally speaking, the doses of caffeine used in studies range from 2-9 mg/kg (about 250-700 mg caffeine), taken 1 hour or less prior to the event. Clearly, an ergogenic effect of caffeine in aerobic activity is demonstrated in doses that would not reach the disqualifying levels of NCAA and IOC sport, as it takes approximately 9 mg/kg consumed to achieve a urinary concentration of 12 µg/mL. The use of caffeine is not surprisingly common. Caffeine does not have the stigma branded to it that some supplements do, and is quite safe. It is likely that many Olympians use caffeine since the cut-off for disqualification is considered high enough to warrant taking the risk. Survey Results Table 1: Age of Survey Participants 18-24 25-29 30-34 35-39 72% 14% 6% 2% 40-44 0% Table 2: Gender of Survey Participants Male 46% Female 54% 45-49 4% 50-54 2% 55-59 0% Linking Consumer 1 0 Table 3: Participants Rate of Activity Level Not Active Active Moderately Active 0% 20% 44% Table 4: Participants Days per Week of Exercise 1 2 3 4 12% 4% 18% 14% 5 36% Very Active 36% 6 16% 7 0% Table 5: Consumed caffeine prior to exercise. Yes No 32% 68% Table 6: Consumption of caffeine prior to exercise made participant feel: Anxious Hyper NonEnergized Other* Drowsy 12% 16% 10% * The option of ‘other’ was to be listed. Some comments were: “its addicting, too many side effects”…”caffeine hinders my performance”…”I think it causes cramps”…”it dehydrates me”…”it gives me a stomach ache when I work out”…”I exercise early and drink coffee afterwards”…”I feel over anxious and hyper”…”caffeinate beverages don’t hydrate very well”…”it helps have a bowel movement” Table 7: Does the consumer feel that caffeine does or does not effect performance? Does Does Not Did Not Answer 64% 14% 10% 20 females / 17 males 2 females / 5 males 4 females /1 male Table 8: How do you feel that consuming caffeinated beverages/products prior to exercise effects performance? Enhances Decreases Neither Did Not Answer 52% 14% 30% 4% Table 9: Do you feel that consuming caffeinated beverages/products prior to exercise effect post exercise mood or energy level? Yes No Did Not Answer 48% 40% 12% Linking Consumer 1 1 Table 10: Products consumed post exercise. Products % of participants Coffee 8% Soda Beverage 30% Tea 18% Energy Drink 4% Energy Tablet 2% 2+ 2 participants 1 participant 2 participants Conclusion Caffeine is a commonly used stimulant among athletes and active individuals (Magkos & Kavours 2005). Caffeine can be derived from many sources of food, energy drinks, supplements, and medications (Magkos & Kavours 2005). Methylxanthines affect the central nervous system, cardiac and skeletal muscle as well as smooth muscle (Magkos & Kavours 2005). Several studies have been done to show that caffeine may have a positive effect on exercise endurance and performance (Magkos & Kavours 2005). The surveys indicate that the physically active consumer has an idea that caffeine does enhance performance, however few participants knew how much caffeine they actually consume. Soda beverages were the most popular product, while energy tablets were the least popular. The majority of the physically active individuals surveyed consumed caffeine. The majority believed that it did indeed enhance performance yet only about one-third used it before they exercise. Survey comments indicate that the caffeine beverages of choice seem to have too many side effects such as, gastrointestinal distress, dehydration, anxiety, and addiction. Caffeine may have some beneficial effects, however its use should be evaluated in regard to the specific effect it may have the user while considering dosages amounts that maximizes potential benefits and minimizes the risks or side effects. Linking Consumer 1 2 References Clark, N.(2003) Sports Nutrition Guidebook(3rd ed.). Brookline, MA: SportsMedicine Associates. p.101-102 Doherty, M., Smith, P., Hughes, M., Davison, R. (2004) Caffeine lowers perceptual response and increase power output during high-intensity cycling. Journal of Sports Sciences, 22, 637-643 Ivanov, A. A., Baskin, I. I., Palyulin, V. A., Zefirov, N. S. (2002) Molecular Modeling of the Human A2a Adenosine Receptor. 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Medical Toxicology: A Synopsis and Study Guide. Philidelphia, PA: Lippincott Williams & Wilkins. p.412-413. Linking Consumer 1 3 Stuart, G., Hopkins, W., Cook, C., Cairns, S.(2005) Multiple effects on caffeine on simulated high-intensity team-sport performance. Medical Science Sports Exercise, 37, 11