VOL. XVIII, No. 1
September 2001
-NEWSLETTER-
Reproductive & Developmental
Toxicology
A Specialty Section of the Society of Toxicology
Editor: Ronald D. Hood
R. D. Hood & Associates
Toxicology Consultants
Box 870344
The University of Alabama
Tuscaloosa, AL 35487-0344
TEL: (205) 348-1817
FAX: (205) 348-1786
E-mail: rhood@bsc.as.ua.edu
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PRESIDENT’S MESSAGE
11th
October 2001
Congratulations to
the new members of
the Executive
Committee of the
Reproductive and
Developmental Toxicology
Specialty Section
(RDTSS), Carole Kimmel (Vice
President-elect) and Ronald Hines
(Junior Councilor). The full slate of
Executive Committee officers is listed
elsewhere in this newsletter. I also
would like to welcome and congratulate
the new editor of our RDTSS
Newsletter, Ron Hood, and thank the
former editor, Debra Kirchner, for her
excellent service. Many thanks to our
outgoing President, Rita Loch-Caruso
(now Past President), Past President,
Paul Foster, and Senior Councilor, Dana
Shuey, for their valued contributions to
the RDTSS.
I would like to thank those who
contributed to the success of RDTSS
activities for the 2001 annual meeting.
In addition to Rita Loch-Caruso, this
includes Kimberly Treinen, who
organized the judging of awards for
students and postdoctoral fellows, and
the awards judges, Kim, Robert Chapin,
and John Rogers. My thanks to Paul
Foster (organizer) and to Paul, Robert
Chapin and Bob Kavlock for serving as
judges for the Best Paper Award for
Toxicological Sciences. I also thank
Dana Shuey (organizer) and Kim
Treinen for serving as judges for the
Best Paper Award in Toxicology and
Applied Pharmacology. My
congratulations to the award winners,
listed elsewhere in this newsletter, and
particularly to the trainees, who
represent our future.
In the competition among sponsored
and co-sponsored proposals for
programs for the 2002 annual meeting,
the RDTSS had great success, with
acceptance of three Symposia, three
Workshops, and two Continuing Education
Programs. These are listed elsewhere in
this newsletter. My thanks go to the
RDTSS members for their efforts in
preparing excellent proposals. For the few
proposals that were not selected for this
year, I encourage the members to resubmit them for the 2003 annual meeting,
for which we should now begin to plan.
Our Vice President, Kimberly Treinen, will
soon be organizing a Program Committee
to review proposals for RDTSS
sponsorship and co-sponsorship, and I
encourage you all to seriously consider
submitting a proposal for a symposium,
workshop, continuing education program,
or roundtable discussion. These programs
constitute the heart of the annual meeting,
and the submission of proposals, along
with our trainee and best paper awards,
are major RDTSS contributions to SOT
and the future of the field. The program
forms for online completion can be found
on the SOT website, and proposals can be
emailed to Kim at
(kimberley.treinen@spcorp.com). While
Kim has not yet established the RDTSS
deadline for proposal submissions, our
goal is to have a slate of proposals
selected and circulated to the RDTSS
membership for their consideration prior to
the annual meeting. Accordingly, the
sooner we begin, the better!
You also will be receiving a request for
nominations from Ronald Hines, this year’s
chair of the RDTSS Nominating
Committee, which selects new officers for
the Executive Committee. I urge you to
consider volunteering as a nominee or
suggest the name of a colleague. If you
have not served before, this provides an
excellent opportunity to contribute to the
value of your Society, and provides
interesting collegial interactions and
insights into the RDTSS and SOT.
The initiative that I will attempt to facilitate
over the coming year is an improvement in
information archiving and communication
within the RDTSS. This is practically
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achievable, primarily via further
development of the RDTSS section of
the SOT website. It would improve the
functioning of the Executive Committee
and enhance services to RDTSS
members. I would appreciate any
suggestions from members as to what
you would like to see added or changed,
and of course any volunteers to work on
providing information that would be of
benefit. You can review some of the
other Specialty Sections’ listings within
the SOT website for examples. Added
information might include a history of the
RDTSS, an archive of Executive
Committee members and award
winners/supervisors/institutions, duties
of executive officers, deadlines for
various documents, unofficial operating
guidelines, detailed criteria for trainee
award submissions, criteria for the
selection of awards judges and for the
ranking process, list of e-mail addresses
for the current executive officers and
newsletter editor, links to websites
relevant to the RDTSS, an online edition
of the current RDTSS Newsletter, an
archive of previous issues, etc. The
online newsletter could include notices
of relevant scientific meetings and other
issues of importance to the
membership, perhaps updated
whenever necessary. Please e-mail
your thoughts to members of the
Executive Committee or to me at
pg.wells@utoronto.ca.
held in Nashville, Tennessee, from March
17 through 21.
In closing, I thank you for the
opportunity to serve the RDTSS, and
encourage you to contribute to its
various programs.
Workshops
Peter Wells
SOT 2002
It is not too soon to
begin planning for the
41st Annual Meeting
of the Society of
Toxicology to be
The following are being sponsored or cosponsored by the RDTSS:
Continuing Education Courses
Alterations in Gene Expression as a
Mechanism of Toxicant Action
(Co-sponsored with the Molecular Biology
Specialty Section and the Regulatory and
Safety Evaluation Specialty Section)
Strategies and Issues in Non-Clinical
Development of Intravenous Infusion Drug
Products
(Co-sponsored with the Regulatory and
Safety Evaluation Specialty Section)
Symposia
Molecular Mechanisms of Chemical
Teratogenesis
Defining the Cellular and Molecular
Mechanisms of Toxicant Action in the
Testis
The Potential for Biological Modeling to
Improve Children’s Risk Assessment
Applications of Transgenic Models
Towards Understanding Mechanisms of
Developmental and Reproductive
Toxicology
Is There A Reproductive Risk Associated
with Exposure to Disinfection By-Products
of Drinking Water?
Non-Clinical Pharmaceutical Pediatric Drug
Testing
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RDTSS OFFICER ROLL CALL
The RDTSS thanks the members who
have graciously agreed to accept
nominations for Vice President-Elect
and Councilor. The 2001-2002 officers
are:
President: Peter G. Wells
Vice President: Kimberley A. Treinen
Vice President-elect: Carole A. Kimmel,
Secretary/Treasurer: Terryl J. Mast
Past President: Rita Loch-Caruso
Councilors: Kathleen T. Shiverick and
Ronald Hines
See the end of this newsletter for
contact information for these officers.
CALL FOR NOMINATIONS
The RDTSS is calling for nominees for
the following positions for the 2002-2003
Executive Committee:
 Vice President-Elect
 Secretary/Treasurer
Questions regarding the duties
associated with these positions can be
addressed to the existing officers.
Please send names and contact
information for nominees to Ron Hines
at rhines@mcw.edu.
CALL FOR NEWS
Please send any newsworthy items to
the RDTSS Newsletter Editor, Ron
Hood, at the address listed on the cover
page. E-mail is the preferred way to
send news, either in the body of the
message or as an attachment. It is
anticipated that the newsletter will be
published twice each year, as has been
the case in the past few years.
2001 STUDENT/POSTDOCTORAL
AWARD WINNERS
Kimberley Treinen, Schering-Plough
Research Institute, Robert Chapin, DuPont
Pharmaceuticals, and John
Rogers, US EPA, made
the student awards
following judging and
deliberations. The 1st place
awards in both categories consisted of an
SOT plaque, a $500 cash award, and a
$130 Taylor & Francis Book Certificate.
The students listed below received welldeserved recognition at the 2001 SOT
Annual Meeting in San Francisco, CA.
The RDTSS thanks Taylor & Francis for
their generosity in providing the book
certificate awards, and Phyllis Cohen, our
Taylor & Francis contact person, for her
efforts on our behalf.
The winners were as follows:
Pre-doctoral award—Mark R. Fielden,
"Male Reproductive and Genomic Effects
of Developmental Exposure to
Diethylstilbestrol in Mice," M.R. Fielden,
R.G. Halgren, C.J.Fong, K. Chou,
P.M.Saama, and T.R. Zacharewski.
Biochemistry and Molecular Biology, and
Animal Science, Michigan State University,
East Lansing, MI (Abstract #1178).
Post-doctoral award—Barry S. McIntyre
"Testicular Atrophy Resulting from In Utero
Linuron Exposure is Secondary to
Epididymal Malformations," B.S. McIntyre,
N.J. Barlow, and P.M.D. Foster. CIIT,
Research Triangle Park, NC (Abstract
#1027).
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BEST JOURNAL PAPER AWARDS
The winner of the award for best paper
in Toxicological Sciences
was:
Ralph L Cooper, Tammy E
Stoker, Lee Tyrey,
Jerome M Goldman and
W Keith McElroy. 2000. Atrazine
disrupts the hypothalamic control of
pituitary-ovarian function. Toxicol. Sci.
53:297-307.
The winner of the award for best paper
in Toxicology and Applied
Pharmacology was:
Mirkes PE, Little SA. 2000. Cytochrome
c release from mitochondria of early
postimplantation murine embryos
exposed to 4-hydroperoxycyclophosphamide, heat shock, and staurosporine. Toxicol. Appl. Pharmacol.
162:197-206.
CALL FOR 2002 APPLICATIONS FOR
GRADUATE STUDENT/POSTDOCTORAL
RESEARCH AWARDS
Applications are now being accepted for
consideration for the 2002 RDTSS
meeting to be held during the 41st
Annual Meeting of the Society of
Toxicology in Nashville, Tennessee.
The awards in both categories (graduate
student and postdoctoral) are:
1st place—an SOT plaque, $500 cash
award, and $130 Taylor & Francis Book
Certificate; 2nd place—an SOT plaque,
$300 cash award, and $100 Taylor &
Francis Book Certificate. If the number
of applications submitted is too low,
however, only first place awards may be
made.
Applicants for the awards must submit the
following by November 4, 2001:
1. An expanded abstract, including the
reason for the study and the significance of
the results.
2. A letter of support by the
student/postdoctoral fellow’s sponsor.
3. A cover letter outlining the significance
of the work to the field of reproductive or
developmental toxicology.
4. Finalists will be expected to submit a full
presentation for consideration by January
4, 2002.
All submitted documents will be treated as
privileged information. The winning
candidates will be recognized at the
RDTSS Annual Meeting.
Initial applications must be submitted by
November 4, 2001, to Dr. Carole A.
Kimmel via one of the following:
(for US mail) NCEA/ORD/US EPA
(8623D), Ariel Rios Bldg., 1200
Pennsylvania Ave. NW, Washington, DC
20460;
(for courier/overnight only) NCEA/ORD/US
EPA (8623D), 808 17th Street NW, Room
500C, Washington, DC 20006
Telephone: (202) 564-3307
Fax: (202) 565-0078
E-mail: kimmel.carole@epa.gov
NEWS ITEM
Paul Foster was selected as
the RDTSS candidate for
the SOT Nominating
Committee. This SOT committee is composed of one
representative from each of
the following groups: Regional Chapters,
Specialty Sections, Past Presidents, the
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membership at large. The election
ballot will list several candidates from
each of these groups, and one from
each group will be elected by plurality
vote of the SOT membership.
2001-2002 RDTSS OFFICER
CONTACT INFORMATION
President
Peter G. Wells
University of Toronto
Department of
Pharmacy
19 Russell Street
Toronto, Ontario M5S 2S2
Canada
TEL: (416) 978-3221
FAX: (416) 267-7797
E-mail: pg.wells@utoronto.ca
Vice President
Kimberley A. Treinen
Schering-Plough Research Institute
PO Box 32
144 Route 94
Lafayette, NJ 07848-0032
TEL: (973) 940-4327
FAX: (973) 940-4509
E-mail: kimberley.treinen@spcorp.com
Vice President-elect
Carole A. Kimmel
US EPA
National Center for Environmental
Assessment (8623-D)
Ariel Rios Building
1200 Pennsylvania Ave., N.W.
Washington, DC 20460
TEL: (202) 564-3307
FAX: (202) 565-0078
E-mail: kimmel.carole@epa.gov
Secretary/Treasurer
Terryl J. Mast
Battelle
Pacific Northwest National Laboratory
PO Box 999, K3-54
Richland, WA 99352
TEL: (509) 375-2032
FAX: (509) 375-2019
E-mail: terry.mast@pnl.gov
Past President
Rita Loch-Caruso
University of Michigan
Department of Environmental & Industrial
Health
1420 Washington Heights
Ann Arbor, MI 48109-2029
TEL: (734) 936-1256
FAX: (734) 647-9770
E-mail: rlc@umich.edu
Senior Councilor
Kathleen T. Shiverick
University of Florida
Department of Pharmacology &
Therapeutics
1600 S.W. Archer Road
Box 100267
Gainesville, FL 32610
TEL: (352) 392-3545
Fax: (352) 392-9696
E-mail: Kshiveri@college.med.ufl.edu
Freshman Councilor
Ronald Hines
Birth Defects Research Center
Department of Pediatrics
Medical College of Wisconsin and
Children’s Hospital of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-4801
TEL: (414) 456-4322
FAX: (414) 456-6651
E-mail: rhines@mcw.edu