Biology Genetics Practice Problems These worksheets are required before retaking quizzes. Review/Practice Packet Mendelian (Prob. Set I) 1. For each genotype, indicate whether it is heterozygous (Het) or homozygous (HO) AA _____ Bb _____ Cc _____ Dd _____ Pointed heads are dominant to round heads. Ee _____ ff _____ GG _____ HH _____ pointed ____________ Ii ______ Jj ______ kk ______ Ll _____ pointed __________________ Mm ____ nn _____ OO _____ Pp ____ round 2. For each of the genotypes below, determine the phenotype. Purple flowers are dominant to white flowers 4. __________________ Set up the Punnett square for each of the crosses listed below. The trait being studied is round seeds (dominant) and wrinkled seeds (recessive) PP ____________________________________ Rr x rr Pp ____________________________________ pp ____________________________________ Round seeds are dominant to wrinkled RR ____________________________________ Rr _____________________________________ What percentage of the offspring will be round? _______ rr _____________________________________ Brown eyes are dominant to blue eyes Rr x Rr BB _____________________________________ Bb _____________________________________ bb ______________________________________ Bobtails are recessive (long tails dominant) TT ______________________________________ What offspring percentage of the will be round? _______ Tt _______________________________________ tt ________________________________________ 3. RR x Rr For each phenotype, list the genotypes. (Remember to use the letter of the dominant trait) Straight hair is dominant to curly. straight ____________ straight____________ curly What offspring percentage of the will be round? ________ ____________ Mrs. Loyd cschmittloyd@waukeeschools.org Page 1 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Mendelian (Prob. Set I) Practice with Crosses. Show all work! 5. A TT (tall) plant is crossed with a tt (short plant). What percentage of the offspring will be tall? ___________ 6. A Tt plant is crossed with a Tt plant. What percentage of the offspring will be short? 11.Two plants, both heterozygous for the gene that controls flower color are crossed. What percentage of their offspring will have purple flowers? What percentage will have white flowers? 12. In guinea pigs, the allele for short hair is dominant (SS). What genotype would a heterozygous short haired guinea pig have? What genotype would a pure-breeding short haired guinea pig have? What genotype would a long haired guinea pig have? 7. 8. A heterozygous round seeded plant (Rr) is crossed with a homozygous round seeded plant (RR). What percentage of the offspring will be homozygous (RR)? A homozygous round seeded plant is crossed with a homozygous wrinkled seeded plant. What are the genotypes of the parents? 13. Show the cross for a pure-breeding short-haired guinea pig (SS) and a long haired (ss) guinea pig. What percentage of the offspring will have short hair? 14. Show the cross for two heterozygous guinea pigs. __________ x __________. What percentage of the offspring will also be homozygous? What percentage of the offspring will have short hair? What percentage of the offspring will have long hair? 9. In pea plants purple flowers are dominant to white flowers. If two white flowered plants are cross, what percentage of their offspring will be white flowered? 15. Two short-haired guinea pigs are mated several times. Out of 100 offspring, 25 of them have long hair. What are the probable genotypes of the parents? ________ x ________ Show the cross to support your answer 10. A white flowered plant is crossed with a plant that is heterozygous for the trait. What percentage of the offspring will have purple flowers? Mrs. Loyd cschmittloyd@waukeeschools.org Page 2 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Mendelian (Prob. Set I) GG = gray hair Gg = gray hair gg = white hair 1. BB = black eyes Bb = black eyes bb = red eyes What are the phenotypes (descriptions) of rabbits that have the following genotypes: Ggbb ____________________ ggBB ________________________ ggbb ____________________ GgBb _________________________ 2. A male rabbit with the genotype GGbb is crossed with a female rabbit with the genotype ggBb The square is set up below. Fill it out and determine the phenotypes and proportions in the offspring. How many out of 16 have grey fur and black eyes? ____ How many out of 16 have grey fur and red eyes? _____ How many out of 16 have white fur and black eyes? ____ How many out of 16 have white fur and red eyes? _____ 3. A male rabbit with the genotype GgBb is crossed with a female rabbit with the genotype GgBb The square is set up below. Fill it out and determine the phenotypes and proportions in the offspring. How many out of 16 have grey fur and black eyes? ____ How many out of 16 have grey fur and red eyes? _____ How many out of 16 have white fur and black eyes? ____ How many out of 16 have white fur and red eyes? _____ 4. Show the cross between a ggBb and a GGBb. You'll have to set the square up yourself! Mrs. Loyd cschmittloyd@waukeeschools.org Page 3 of 20 7/12/16 www.loydbiology.weebly.com Genetics Review/Practice Packet Mendelian (Prob. Set I) How to set up dihybrid crosses A) Figure out the genotypes of both traits for both parents. B) Write out the parents’ genotypes together C) Use the F i r s t O u t s i d e I n s i d e L a s t ex. AABB X aabb method to set up the test cross 1) Draw the arrows for each parent for the FOIL method. An example is given below. Parent 1 Parent 2 A 2) Set up the cross for both sides. A B B X a a b b Parent 1 AB Parent 2 Mrs. Loyd cschmittloyd@waukeeschools.org Page 4 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Mendelian (Prob. Set I) 3) Practice filling in the probable offspring below. AB AB AB ab AB AaBb ab ab ab 4) To figure the phenotypic ratio, count the number of individuals with either the dominant or recesssive phenotype for both traits! Then that ratio would be something like 4:4:4:4 or 9:3:3:1 PTC-taster- TT, Tt Non-PTC taster – tt Hitchhikers thumb- HH, Hh Straight thumb – hh Hair on mid-digit – MM, Mm No hair on mid-digit- mm Attached earlobes- EE, Ee Free earlobes – ee Straight pinky- PP, Pp Bent pinky- pp Widow’s peak- WW, Ww No widow’s peak- ww Dihybrid Crosses. Set up the crosses using the rules and the letters from the other page. 1. Can roll tongue- RR, Rr Can’t roll tongue - rr Now practice! If a woman who is a non-PTC taster (recessive) with heterozygous hitchhikers thumb has children with a man who is a heterozygous PTC taster with straight thumbs (recessive), what is the probability of them having each of the following types of children? (Fill in the Punnett Square and the blanks). Parents’ genotypes ____________ X ____________ a. How many PTC taster, Hitchhikers thumb? b. How many PTC taster, straight thumb? c. How many Non-PTC taster, Hitchhikers thumb d. How many Non- PTC taster, straight thumb e. What is the phenotypic ratio? Mrs. Loyd cschmittloyd@waukeeschools.org Page 5 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Mendelian (Prob. Set I) 2. If a woman who has no hair on her mid-digit (recessive)and is homozygous attached earlobes (dominant) has children with a man who has hair on his mid-digit and has attached earlobes (heterozygous for both traits), what is the probability of them having each of the following types of children? (Fill in the Punnett Square and the blanks). Parents’ genotypes ____________ X ____________ 3. a. How many hair, attached earlobes b. How many hair, not attached earlobes c. How many hairless, attached earlobes d. How many hairless, not attached earlobes e. What is the phenotypic ratio? John Doe and Jane Doe want to have children and are thinking about how their childrens’ hands might look. What would their children look like if they are both heterozygous for straight pinky and hitchhikers thumb? (Fill in the Punnett Square and the blanks). Parents’ genotypes ____________ X ____________ 4. a. Straight pinky, hitchhikers thumb b. Straight pinky, Straight thumbs c. bent pinky, hitchhikers thumb d. bent pinky, Straight thumbs e. What is the phenotypic ratio? Dohn Joe and Dane Joe want to have children and are thinking about how their childrens’ hair line and tongues will turn out. They are both circus performers and want their children to follow in their footsteps. Their circus only accepts people with a Widow’s Peak and who can roll their tongues. What would their children look like if Dohn is heterozygous for both Widow’s peak and tongue rolling, and Dane is homozygous dominant for Widow’s peak and heterozygous for tongue rolling? (Fill in the Punnett Square and the blanks). Parents’ genotypes ____________ X ____________ a. Widow’s Peak, Tongue Roller b. Widow’s Peak, non tongue roller c. Straight hair line, Tongue Roller d. Straight hair line, non tongue roller e. What is the phenotypic ratio? f. What are the chances of their child being able to join the circus? Mrs. Loyd cschmittloyd@waukeeschools.org Page 6 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Mendelian (Prob. Set I) This problem will involve both a test cross and a Dihybrid Punnett Square Background information: You are a pigeon breeder. In order to make the most money as a pigeon breeder, you must sell mainly checkered winged, red feather pigeons. Lucky for you checkered wings and red feathers are dominant in pigeons (plain wings and brown feathers are recessive). To breed as many checkered winged, red feather pigeons as possible, you need to breed homozygous checkered winged, red feather pigeons with each other (because all of the offspring would be checkered winged, red feather pigeons). You know you have a female homozygous checkered winged, red feathered pigeon (you bred her yourself!) She is so beautiful that she has won prizes in several pigeon beauty contests. The Problem: You recently purchased a male pigeon that has checkered wings and red feathers from a shady pigeon dealer, who claimed it was homozygous. Before you breed this male with your prize winning female, you want to be sure that it is homozygous for both traits. Describe how you will be able to tell what the genotype for both traits of your pigeon in 1 generation. (test cross here) 5 points a. Illustrate the probable outcomes if your pigeon IS homozygous for both traits. (using a Punnett Square) Mrs. Loyd cschmittloyd@waukeeschools.org Page 7 of 20 7/12/16 www.loydbiology.weebly.com Genetics Review/Practice Packet Non-Mendelian I (Prob. Set 2) Most genetic traits have a stronger, dominant allele and a weaker, recessive allele. In an individual with a heterozygous genotype, the dominant allele shows up in the offspring and the recessive allele gets covered up and doesn’t show; we call this complete dominance. However, some alleles don’t completely dominate others. In fact, some heterozygous genotypes allow both alleles to partially show by blending together how they are expressed; this is called incomplete dominance. Other heterozygous genotypes allow both alleles to be completely expressed at the same time like spots or stripes; this is called codominance. Examples of each are listed below. Write what each type would be if they were heterozygous. 1. Complete dominance = If a Red (RR) and White flower (rr) were crossbred, resulting in 100% Rr, what phenotype would been seen according to the rules of COMPLETE dominance? 2. Incomplete dominance = If a Red (RR) and White flower (rr) were crossbred, resulting in 100% Rr, what phenotype(s) would been seen according to the rules of IN-complete dominance? 3. Codominance = If a Red (RR) and White flower (WW) were crossbred, resulting in 100% RW, what phenotype(s) would been seen according to the rules of CO-dominance? Incomplete dominance practice Problems 4-6. Snapdragons are incompletely dominant for color; they have phenotypes red, pink, or white. The red flowers are homozygous dominant, the white flowers are homozygous recessive, and the pink flowers are heterozygous. Give the genotypes for each of the phenotypes, using the letters “R” and “ r ” for alleles: a. Red snapdragon genotype: ______ b. Pink snapdragon genotype: ______ c. White snapdragon genotype: ______ Show genetic crosses between the following snapdragon parents, using the Punnett squares provided, and record the genotypic and phenotypic %s below: a. pink x pink b. red x white c. pink x white Genotypic Genotypic Genotypic %: ________________ %: ________________ %: ________________ Phenotypic Phenotypic Phenotypic %: ________________ %: ________________ %: ________________ Mrs. Loyd cschmittloyd@waukeeschools.org Page 8 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Non-Mendelian I (Prob. Set 2) 7-9. In horses, some of the genes for hair color are incompletely dominant. Genotypes are as follows: brown horses are BB, white horses are bb and a Bb genotype creates a yellow-tannish colored horse with a white mane and tail, which is called “palomino”. Show the genetic crosses between the following horses and record the genotypic and phenotypic percentages: a. brown x white Genotypic %: ________________ Phenotypic %: ________________ b. brown x palomino c. palomino x palomino Genotypic %: ________________ Phenotypic %: ________________ Genotypic %: ________________ Phenotypic %: ________________ 10. Can palominos be considered a purebred line of horses? Why or why not? 11. Which two colors of horse would you want to breed if you wanted to produce the maximum in the shortest amount of time? numbers of palominos 12. In Smileys, eye shape can be starred (SS), circular (CC), or a circle with a star (CS). Write the genotypes for the pictured phenotypes _________ __________ ___________ 13. Show the cross between a star-eyed and a circle eyed. What are the phenotypes of the offspring? ____________ What are the genotypes? __________ 14. Show the cross between a circle-star eyed, and a circle eyed. How many of the offspring are circle-eyed? ____________ How many of the offspring are circle-star eyed? ____________ 15. Show the cross between two circle-star eyed. How many of the offspring are circle-eyed? ____________ How many of the offspring are circle-star eyed? ____________ How many are star eyed? ___________ Mrs. Loyd cschmittloyd@waukeeschools.org Page 9 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Non-Mendelian I (Prob. Set 2) Name ____________________________________ Practice: Codominance and Incomplete Dominance Figure out which of the combinations represent codominant traits and which are incomplete. Remember that the "medium" trait must always be heterozygous. Put “Co” or “I” next to each letter. a) Birds can be blue, white, or white with blue-tipped feathers. b) Flowers can be white, pink, or red. c) A Hoo can have curly hair, spiked hair, or a mix of both curly and spiked. d) A Sneech can be tall, medium, or short. e) A Bleexo can be spotted, black, or white. Mrs. Loyd cschmittloyd@waukeeschools.org Page 10 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Non-Mendelian I (Prob. Set 2) All chickens have combs on their heads, but it does not always look the same. The comb is a fleshy growth on the top of the chicken's head. Both male and female chickens have combs, but the ones on the male are larger. Combs of different breeds may look different in shape and even in color. 1. On the cross pictured below, what must be the genotypes of the two parents for the outcome to always be a walnut offspring? ____________ x _____________ 2. Show a Punnett square for the following cross and describe the phenotypic ratios. RrPp x RrPp Show a Punnett square for the following cross and describe the phenotypic ratios. 4. Single comb x Walnut (RrPp) 6. A rose crossed with a pea produces six walnut and five rose offspring. What must be the genotypes of the parents? Show the cross. Show a Punnett square for the following cross and describe the phenotypic ratios. 5. Single comb x Pea comb (rrPp) Mrs. Loyd cschmittloyd@waukeeschools.org Page 11 of 20 7/12/16 www.loydbiology.weebly.com Review/Practice Packet Non-Mendelian I (Prob. Set 2) Codominance Worksheet (Blood types) Human blood types are determined by genes that follow the CODOMINANCE pattern of inheritance. There are two dominant alleles (A & B) and one recessive allele (O). Blood Type (Phenotype) Genotype Can donate blood to: Can receive blood from: O ii (OO) A,B,AB and O (universal donor) O AB IAIB AB A,B,AB and O (universal receiver) A IAIA or IAi (IAO) AB, A O,A B IBIB or I i (IBO) AB,B O,B B 1. Write the genotype for each person based on the description: a. Homozygous for the “B” allele b. Heterozygous for the “A” allele c. Type O d. Type “A” and had a type “O” parent e. Type “AB” f. Blood can be donated to anybody g. Can only get blood from a type “O” donor _________ _________ _________ _________ _________ _________ _________ 2. Pretend that Brad Pitt is homozygous for the type B allele, and Angelina Jolie is type “O.” What are all the possible blood types of their baby? (Do the punnett square) _________________________________________________________________ 3. Complete the punnett square showing all the possible blood types for the offspring produced by a type “O” mother and an a Type “AB” father. What are percentages of each offspring? _________________________________________________________________ 4. Mrs. Essy is type “A” and Mr. Essy is type “O.” They have three children named Matthew, Mark, and Luke. Mark is type “O,” Matthew is type “A,” and Luke is type “AB.” Based on this information: a. Mr. Essy must have the genotype ______ b. Mrs. Essy must have the genotype ______ because ___________ has blood type ______ c. Luke cannot be the child of these parents because neither parent has the allele _________ Page 12 of 20 4/10/15 Review/Practice Packet Non-Mendelian I (Prob. Set 2) 5. Two parents think their baby was switched at the hospital. Its 1968, so DNA fingerprinting technology does not exist yet. The mother has blood type “O,” the father has blood type “AB,” and the baby has blood type “B.” a. Mother’s genotype: _______ b. Father’s genotype: _______ c. Baby’s genotype: ______ or ________ d. Punnett square showing all possible genotypes for children produced by this couple. e. Was the baby switched? _______________________ 6. Two other parents think their baby was switched at the hospital. Amy the mother has blood type “A,” Linville the father has blood type “B,” and Priscilla the baby has blood type “AB.” 7. a. Mother’s genotype: _______ or ________ b. Father’s genotype: _______ or ________ c. Baby’s genotype: ______ d. Punnett square that shows the baby’s genotype as a possibility e. Could the baby actually be theirs? _________________________ Based on the information in this table, which men could not be the father of the baby? (hint… look at the baby’s blood type only…)______________________________ You can use the Punnett square if you need help figuring it out. 8. The sister of the mom above also had issues with finding out who the father of her baby was. She had the state take a blood test of potential fathers. Based on the information in this table, why was the baby taken away by the state after the test? (hint… look at the baby’s blood type only…)______________________________ ____________________________________ Name Blood Type Name Blood Type Mother Type A Mother Type O Baby Type B Baby Type AB The mailman Type O Bartender Type O The butcher Type AB Guy at the club Type AB The waiter Type A Cabdriver Type A The cable guy Type B Flight attendant Type B Page 13 of 20 4/10/15 Review/Practice Packet Non-Mendelian I (Prob. Set 2) BLOOD TYPE & INHERITANCE In blood typing, the gene for type A and the gene for type B are codominant. The gene for type O is recessive. Using Punnett squares, determine the possible blood types of the offspring when: 1. Father is type O, Mother is type O __________% __________% __________% __________% O A B AB 2. Father is type A, homozygous; Mother is type B, homozygous __________% __________% __________% __________% O A B AB 7. Father is type A, heterozygous; Mother is type B, heterozygous __________% __________% __________% __________% O A B AB 8. Father is type O, Mother is type AB __________% __________% __________% __________% O A B AB 9. Father and Mother are both type AB __________% __________% __________% __________% Page 14 of 20 O A B AB 4/10/15 Review/Practice Packet Non-Mendelian II (Prob. Set 3) Genetics: X Linked Genes In fruit flies, eye color is a sex linked trait. Red is dominant to white. 1. What are the sexes and eye colors of flies with the following genotypes: X R X r _________________ X R X R _________________ X R Y _________________ X r Y _________________ 2. What are the genotypes of these flies: white eyed, male ____________ white eyed, female ___________ red eyed female (heterozygous) ________ red eyed, male ___________ 3. Show the cross of a white eyed female X r X r with a red-eyed male X R Y . 4. Show a cross between a pure red eyed female and a white eyed male. What are the genotypes of the parents: ___________ X _______________ How many are: white eyed, male___ white eyed, female ___ red eyed, male ____ red eyed, female ____ 5. Show the cross of a red eyed female (heterozygous) and a red eyed male. What are the genotypes of the parents? ___________ X ________________ How many are: white eyed, male___ white eyed, female ___ red eyed, male ____ red eyed, female ____ Math: What if in the above cross, 100 males were produced and 200 females. (think about the percentage of the total #) 6. How many total red-eyed flies would there be? Page 15 of 20 4/10/15 Review/Practice Packet Non-Mendelian II (Prob. Set 3) 7. In humans, hemophilia is a sex linked trait. Females can be normal, carriers, or have the disease. Males will either have the disease or not (but they won’t ever be carriers) = female, normal = male, normal = female, carrier = male, hemophiliac = female, hemophiliac Show the cross of a man who has hemophilia with a woman who is a carrier. 8. What is the probability that their children will have the disease? __________ 9. A woman who is a carrier marries a normal man. Show the cross. What is the probability that their children will have hemophilia? What sex will a child in the family with hemophilia be? 10. A woman who has hemophilia marries a normal man. How many of their children will have hemophilia, and what is their sex? Page 16 of 20 4/10/15 Review/Practice Packet Non-Mendelian II (Prob. Set 3) Pedigree Worksheet Use the given pedigrees to answer the following questions: The pedigree to the right shows the passing on of straight thumbs (recessive) and Hitchhiker’s Thumb (dominant) in a family. Shaded shapes mean the person has a straight thumb I 1 II 2 1 3 2 1 III IV 4 2 1 2 3 4 3 1. What is the genotype of IV-1? 5. What is the genotype II-3? 2. What is the genotype IV-3? 6. Is it possible for individual IV-2 to be a carrier? 3. What is the genotype of III-1? 4. What is the genotype III-2? 8. The pedigree to the right shows the passing on of colorblindness (a recessive, sexlinked trait). Fill in the numbers for each generation (generation IV is done for you). 9. What do the half shaded circles mean? 7. Why/Why not? I III I 10. What is the ONLY gender that carriers of colorblindness can be? 9. Which individuals are colorblind? ____________________________________ 10. What is the genotype of person II-2? 11. What is the genotype of person I-1? III IV 1 2 3 4 5 6 7 8 12. What is the genotype of person III-3? 13. If person IV-1 marries a female who is not colorblind and is not a carrier, what are the chances of their male offspring being colorblind? 14. What about their female offspring? Page 17 of 20 4/10/15 Review/Practice Packet Non-Mendelian II (Prob. Set 3) = Sickle Cell Anemia I 1 2 4 5 II 1 III 1 2 2 3 3 4 6 7 8 5 NOTE- carriers are not shown on this pedigree although Sickle Cell Anemia IS A RECESSIVE DISORDER. 11. Which members of the family above are afflicted with sickle cell anemia? 12. How are individuals III-4 and III-5 related? 13. How are individuals I-1 and I-2 related? 14. How are individuals II-7 and III-2 related? 15. How are individuals I-2 and III-5 related? 16. How many children did individuals I-1 and I-2 have? 17. How many girls did II-1 and II-2 have? ___________ How many have sickle cell anemia? 18. Label the possible genotypes for all individuals in the pedigree. One person can have more than one possible genotype Page 18 of 20 4/10/15 BIOLOGY Problem Set with Probability Calculations Solve the following genetics problems. Show your work as clearly and completely as possible. Hint: when the problem gives you genetic information, get it written down. 1. During a recent hunting season, a male and female otter were captured and mated. Both otters were of the southern species, so they were dark brown in color. Once the offspring were born, the owners noticed quite a few little creamcolored otters running around, as well as a large number of little dark brown otters. If both parents were heterozygotes and there were 48 little brown otters, how many little cream-colored otters were there? Show your Punnett square work. 2. For this question, use your imagination. A pink elephant and a green elephant were mated and only pink baby elephants were born of the union. It two of these offspring were mated and eventually produced a total of 64 baby elephants, how many of these should be pink and how many should be green? Show your Punnett square work. 3. Brown color in mice is dominant over albinism. In a given cross between a brown mouse and an albino mouse, six of the offspring were brown and five were albinos. What was the genotype of the original brown parent? Show your punnett square work. 4. Starchy grain is dominant over sugary grain in corn. If, in a cross between these two types, 58 of the offspring were sugary, how many would be starchy? Show your Punnett square work. 5. A certain white-fruited squash; when selffertilized, produced both white and yellow-fruited squash offspring. If 21 of the offspring were yellow, how many white squash would be expected? Show your Punnett square work. 6. Short hair is dominant over long hair in guinea pigs. A short-haired guinea pig, one of whose parents was a long-haired animal, was mated with a long-haired guinea pig. If, blindfolded, you selected one of their litter from the cage, what is the chance you would get a long-haired animal? 7. If an animal with the genotype Cc produces 100 eggs, how many of these eggs should have the genetic formula C? How many probably have the formula c? How many have the formula Cc? Why? 8. Applying the rules relating to the choice of symbols for genes, make a number of matings between trotting horses, Tt and Tt, and obtain 24 foals. How many of these foals would be pacers? Use a Punnett square to explain why. Page 19 of 20 4/10/15 BIOLOGY Problem Set with Probability Calculations 9. If two parents, who have the same visible characteristics, produce some offspring that are like the parents, and some different, write the formulas of the parents using any symbols you choose. Show the Punnett square. _______ x _______ 10. In eye color, the darker colors are usually dominant over lighter ones. A brown-eyed boy whose mother had blue eyes married a brown-eyed girl whose father had blue eyes. What is the chance that their first-born child will be blue-eyed? Show your work. 11. Two brown minks mated and produced brown and silver-blu babies. What were the genotypes of the parents? Show your Punnett square work. _______ x _______ 12. Melanoma is a cancer of the skin. A normal woman (without melanoma) married a man with melanoma. They had two children, A and B. The man then had an operation and the melanoma was successfully removed. They then had two additional children, C and D. What would be the phenotypes of children A, B, C, and D? Explain. Page 20 of 20 4/10/15