Standardized Syllabus for the College of Engineering BME 4311 Molecular Biomedical Engineering. 1. Catalog Description (3 credits) An introductory course in the fundamentals of Molecular Biology for Biomedical Engineers. This course is designed for Junior or Senior biomedical engineering students where they will learn the nomenclature, and current state of knowledge of the eukaryotic cell and it’s related structures. Topics covered in this course: Protein structure and function, Enzymes. The structure and nature of DNA, cellular structure and function of various cellular organelles. In addition they will learn energy and the function of mitochondria and chloroplast, cellular communication, and the function of the extracellular matrix. 2. Pre-requisites BSC 2010, PCB 3XXX Cell & Systems Physiology, CHM 3217 3. Course Objectives To introduce students to molecular biology within a quantitative context. Transduction, transmission, storage and retrieval of biological information. Structure of DNA, RNA and proteins. Gene regulation, simple genetic circuits. Molecular interactions. Biomolecular motors. Metabolic and signal transduction networks. 4. Contribution of course to meeting the professional component (ABET only) 5. Relationship of course to program outcomes (ABET only) 6. Instructor - TBA a. Office location b. Telephone c. E-mail address d. Web site e. Office hours 7. Teaching Assistant - TBA a. Office location b. Telephone c. E-mail address d. Office hours 8. Meeting Times Course meets 3 times per week, schedule TBA 9. Class/laboratory schedule Course meets 3 50 minute periods per week 10. Meeting Location – TBA 11. Material and Supply Fees – None 12. Textbooks and Software Required Molecular Biology of the Cell Alberts et. al. Garland Science 5th edition. ISBN 0815332181 13. Recommended Reading (see 12 above) 14. Course Outline Week 1 Cell Chemistry and Biosynthesis Week 2 Proteins Shapes, structures and function. Week 3 Enzyme function Week 4 DNA chromosomes and genomes Week 5 Membrane Structure Week 6 Membrane Transport and Small Molecules Week 7 Intracellular Compartments and Protein Sorting Week 8 Intacellular Vesicular Traffic Week 9 Energy Conversion: Mitochondria Week 10 Mechanism of Cell Communication Week 11 Cytoskeleton Week 12 Cell Cycle Week 13 Apoptosis Week 14 Biomolecular Motors Week 15 Gene Regulation 15. Attendance and Expectations Class participation is required and part of the final grade 16. Grading Class participation 5%, quizzes 10% homework 15% midterm 35% final exam 35%. 17. Grading Scale A AB+ B B- C+ C C- D+ D D- E > 90 80-83 77-79 74-76 70-73 67-69 64-66 60-63 57-59 < 56 87-89 84-86 18. Make-up Exam Policy Midterm and Final Exam can be made up in extreme circumstances and if the instructor is notified before the start of the exam. 19. Honesty Policy All students admitted to the University of Florida have signed a statement of academic honesty committing themselves to be honest in all academic work and understanding that failure to comply with this commitment will result in disciplinary action. This statement is a reminder to uphold your obligation as a UF student and to be honest in all work submitted and exams taken in this course and all others. 20. Accommodation for Students with Disabilities Students Requesting classroom accommodation must first register with the Dean of Students Office. That office will provide the student with documentation that he/she must provide to the course instructor when requesting accommodation. 21. UF Counseling Services Resources are available on-campus for students having personal problems or lacking clear career and academic goals. The resources include: - University Counseling Center, 301 Peabody Hall, 392-1575, Personal and Career Counseling. - SHCC mental Health, Student Health Care Center, 392-1171, Personal and Counseling. - Center for Sexual Assault/Abuse Recovery and Education (CARE), Student Health Care Center, 392-1161, sexual assault counseling. - Career Resource Center, Reitz Union, 392-1601, career development assistance and counseling. 22. Software Use All faculty, staff and student of the University are required and expected to obey the laws and legal agreements governing software use. Failure to do so can lead to monetary damages and/or criminal penalties for the individual violator. Because such violations are also against University policies and rules, disciplinary action will be taken as appropriate. We, the members of the University of Florida community, pledge to uphold ourselves and our peers to the highest standards of honesty and integrity.