Performance of mechanical ventilators for
noninvasive positive pressure ventilation in children
Brigitte Fauroux, Karl Leroux
Gilbert Desmarais, Daniel Isabey, Annick Clément,
Frédéric Lofaso, Bruno Louis.
Table 1: Patient 1 with spinal muscular amyotrophy
Pmax
Pressurisation
PEEP T
PS
ven
P
Ventilators
Setting
slope
(cmH2O) (s) (cmH2O)(cmH2O) tilator
(cmH2O/s)
(cmH2O)
ELYSEE150 double circuit
PSV 10 ZEEP
*
*
*
*
*
*
ELYSEE150 simple circuit
PSV 10 ZEEP
*
*
*
*
*
*
1
LEGENDAIR
PSV 10 ZEEP 0.63 0.28 -0.30
9.8
10.0
14.0
NEFTIS22
PSV 10 ZEEP 0.80 0.27 -0.84
9.1
10.0
48.1
SMARTAIR simple circuit
PSV 10 ZEEP
*
*
*
*
*
*
VS INTEGRA simple circuit
PSV 10 ZEEP
*
*
*
*
*
*
VS ULTRA double circuit flow trigger3
PSV 10 ZEEP 1.43 0.31 -0.83
10.3
10.0
60.1
VS ULTRA simple circuit
PSV 10 ZEEP
*
*
*
*
*
*
VS UTRA double circuit press trigger
PSV 10 ZEEP
*
*
*
*
*
*
ELYSEE150 double circuit
*
*
*
*
*
*
ACV 250 ZEEP
ELYSEE150 simple circuit4
9.8
10.0
14.0
ACV 250 ZEEP 0.28 0.32 -0.75
EOLE3 pressure trigger
ACV 250 ZEEP
*
*
*
*
*
*
EOLE3 flow trigger5
12.2
12.0
37.0
ACV 250 ZEEP 0.05 1.60 2.00
LEGENDAIR
ACV 250 ZEEP
*
*
*
*
*
*
NEFTIS26
10.8
12.0
49.3
ACV 250 ZEEP 0.65 0.28 -0.92
VS ULTRA double circuit flow trigger7 ACV 250 ZEEP 1.41 0.31 -0.71
12.7
12.5
61.7
VS ULTRA simple circuit
ACV 250 ZEEP
*
*
*
*
*
*
VS UTRA double circuit pressure trigger ACV 250 ZEEP
*
*
*
*
*
*
VTm
(L)
VTv
(L)
*
*
0.20
0.20
*
*
0.23
*
*
*
0.25
*
0.30
*
0.25
0.27
*
*
*
*
0.18
0.17
*
*
0.32
*
*
*
0.25
*
0.25
*
0.22
0.34
*
*
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator,
ZEEP: zero end-expiratory pressure, ACV: assist control ventilation.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or auto-triggering.
1auto-triggering
for a leak of 3L/min, the ventilator requires a back up rate slightly below the spontaneous breathing rate
2alarm
for a leak of 6.8L/min, pressure support falls to 6.7 cm H2O
for a leak of 16L/min
4does not detect the inspiratory effort for a leak of 3L/min
5alarm for a leak of 1.2L/min, VT 165 ml
6alarm for a leak of 4.5L/min, VT 140 ml
7alarm for a leak of 3.4 l/min, VT 175 ml
3alarm
Ventilators which do not have a compatible mode: GK425T, HARMONY2, iSLEEP22, KNIGHTSTAR330, SMARTAIR + leak circuit,
SYNCHRONY and SYNCHRONY2, VIVO40,VPAP3ST, VPAP3STA, VS INTEGRA + leak circuit, VS SERENA, VS ULTRA + leak
circuit.
Table 2: Patient 2 with Duchenne muscular dystrophy
Pmax Pressurisation
PEEP T
PS
VTm
P
ventilator
slope
VTv (L)
(cmH2O) (s) (cmH2O)(cmH2O)
(L)
(cmH2O) (cmH2O/s)
PSV16 ZEEP 0.36 0.20 -1.52
16.1
16.0
142.9
0.357 0.384
ELYSEE150 double circuit1
2
ELYSEE150 simple circuit
PSV16 ZEEP 0.47 0.19 -1.33
16.0
16.0
137.2
0.354 0.373
LEGENDAIR3
PSV16 ZEEP 0.64 0.20 -0.59
17.3
16.0
12.6
0.351 0.323
4
PSV16 ZEEP 1.00 0.21 -2.04
14.4
17.0
36.0
0.370 0.300
NEFTIS2
SMARTAIR simple circuit
PSV16 ZEEP
*
*
*
*
*
*
*
*
VS INTEGRA simple circuit
PSV16 ZEEP
*
*
*
*
*
*
*
*
VS ULTRA double circuit flow trigger5
PSV16 ZEEP 1.35 0.17 -1.31
15.9
16.0
100.5
0.370 0.450
VS ULTRA simple circuit6
PSV16 ZEEP 0.89 0.17 -1.37
16.0
17.0
109.9
0.378 0.460
VS UTRA double circuit pressure trigger PSV16 ZEEP
*
*
*
*
*
*
*
*
7
ELYSEE150 double circuit
ACV500 ZEEP 0.40 0.32 -2.08
25.3
26.5
10.4
0.482 0.498
25.1
26.0
7.2
0.476 0.499
ELYSEE150 simple circuit8
ACV500 ZEEP 0.54 0.29 -1.81
EOLE3 pressure trigger
ACV500 ZEEP
*
*
*
*
*
*
*
*
27.7
29.0
10.5
0.504 0.585
EOLE3 flow trigger9
ACV500 ZEEP -0.04 0.15 -0.48
21.9
22.5
32.6
0.473 0.498
LEGENDAIR10
ACV500 ZEEP 0.66 0.12 -0.38
23.0
23.0
37.8
0.474 0.420
NEFTIS211
ACV500 ZEEP 1.01 0.21 -2.09
5
23.2
23.5
69.3
0.431 0.530
VS ULTRA double circuit flow trigger
ACV500 ZEEP 1.38 0.17 -1.30
*
*
*
*
*
*
*
*
VS ULTRA simple circuit
ACV500 ZEEP
VS UTRA double circuit pressure trigger ACV500 ZEEP
*
*
*
*
*
*
*
*
Ventilators
Setting
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator,
ZEEP: zero end-expiratory pressure, ACV: assist control ventilation.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or autotriggering.
1no
detection of inspiratory effort or autotriggering for a leak of 16L/min
for a leak of 8.8L/min
3alarm for a leak of 78 L/min, pressure 14/0, the ventilator requires a back up rate slightly below the spontaneous breathing
4alarm for a leak of 7.5 L/min, pressure support falls to 12.5 cmH O
2
5-autotriggering for a leak of 15L/min
6no detection of inspiratory effort or autotriggering for a leak of 16L/min
7no detection of inspiratory effort or autotriggering for a leak of 5L/min
8alarm for a leak of 5L/min, VT 285 ml
9alarm for a leak of 7.0 L/min, VT 302 ml
10does not detect the inspiratory effort or auto-triggering for a leak of 12 L/min, the ventilator requires a back up rate slightly below
the spontaneous breathing
11alarm for a leak of 8.6 L/min, VT 300 ml
2autotriggering
Ventilators which do not have a compatible mode: GK425T, HARMONY2, iSLEEP22, KNIGHTSTAR 330, SMARTAIR + leak circuit,
SYNCHRONY and SYNCHRONY2, VIVO40, VPAP3ST, VPAP3STA, VS SERENA, VS ULTRA + leak circuit.
Table 3: Patient 3 with cystic fibrosis
Ventilators
Setting
ELYSEE150 double circuit1
2
ELYSEE150 simple circuit
LEGENDAIR3
NEFTIS24
SMARTAIR simple circuit5
VS INTEGRA simple circuit
VS ULTRA double circuit flow trigger6
VS ULTRA simple circuit7
VS UTRA double circuit pressure trigger6
ELYSEE150 double circuit7
ELYSEE150 simple circuit
EOLE3 pressure trigger
EOLE3 flow trigger8
LEGENDAIR9
NEFTIS210
VS ULTRA double circuit flow trigger11
VS ULTRA simple circuit12
VS UTRA double circuit pressure
trigger13
Pmax
Pressurisation
PEEP T
PS
ven
VTm
P
slope
(cmH2O) (s) (cmH2O)(cmH2O) tilator
(L)
(cmH2O/s)
(cmH2O)
VTv
(L)
PSV16 ZEEP
0.17
0.33
-1.24
18.5
18.5
170.2
0.263 0.236
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
PSV16 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
ACV500 ZEEP
0.42
0.64
0.97
0.24
*
1.43
0.66
0.30
0.27
*
*
0.0
0.7
1.16
1.40
0.80
0.19
0.06
0.16
0.10
*
0.16
0.13
0.07
0.34
*
*
0.07
0.06
0.16
0.15
0.10
-1.34
-0.53
-1.75
-0.20
*
-1.41
-1.15
-0.69
-1.67
*
*
-0.42
-0.50
-1.76
-1.20
-1.0
18.8
16.6
15.1
16.7
*
16.3
16.2
16.2
27.8
*
*
32.9
27.3
28.4
32.3
32.1
17.5
16.0
16.0
17.0
*
16.0
16.0
16.0
29.0
*
*
33.0
27.0
29.0
31.5
32.5
170.9
7.1
74.4
22.3
*
92.6
119.1
69.0
60.6
*
*
29.8
33.3
106.6
173.4
108.7
0.258
0.240
0.298
0.318
*
0.272
0.286
0.293
0.447
*
*
0.488
0.488
0.472
0.434
0.552
ACV500 ZEEP
0.44
0.14
-0.84
32.1
31.5
102.7
0.454 0.525
0.268
0.190
0.260
0.340
*
0.340
0.315
0.295
0.446
*
*
0.415
0.500
0.420
0.530
0.500
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator,
ZEEP: zero end-expiratory pressure, ACV: assist control ventilation.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or autotriggering.
1no
detection of inspiratory effort or autotriggering for a leak of 10L/min
for a leak of 6L/min
3alarm for a leak of 55L/min, pressure support falls to 16/0, the ventilator requires a back up rate slightly below the spontaneous
breathing
4alarm for a leak of 9L/min, pressure support falls to 9.8 cmH O
2
5without leak, no detection of the inspiratory effort without humidification
6no detection of inspiratory effort or autotriggering for a leak of 9L/min
7no detection of inspiratory effort or autotriggering for a leak of 6L/min
8autotriggering for a leak of 9L/min
9no detection of inspiratory effort or autotriggering for a leak of 8.5L/min, the ventilator requires a back up rate slightly below the
spontaneous breathing
10alarm for a leak of 7.5L/min, VT falls to 230 ml
11autotriggering for a leak of 15L/min
12no detection of inspiratory effort or autotriggering for a leak of 5L/min
13no detection of inspiratory effort or autotriggering for a leak of 5L/min
2autotriggering
Ventilators which do not have a compatible mode: GK425T, HARMONY2, iSLEEP22, KNIGHTSTAR330, SMARTAIR + leak circuit,
SYNCHRONY and SYNCHRONY2, VIVO40, VPAP3ST, VPAP3STA, VS SERENA, VS ULTRA + leak circuit.
Table 4: Patient 4 with laryngomalacia
Pmax
Pressurisation
PEEP T
PS
ven
VTm VTv
P
Ventilators
Setting
slope
(cmH2O) (s) (cmH2O)(cmH2O) tilator
(L) (L)
(cmH2O/s)
(cmH2O)
ELYSEE150 double circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
ELYSEE150 simple circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
GK425ST
PSV14 PEEP8
*
*
*
*
*
*
*
*
HARMONY2
PSV14 PEEP8
*
*
*
*
*
*
*
*
iSLEEP22
PSV14 PEEP8
*
*
*
*
*
*
*
*
1
KNIGTSTAR330
PSV14 PEEP8 8.19 0.21 -0.16
14.6
14.0
46.9
0.051 0.074
LEGENDAIR2
PSV14 PEEP8 8.23 0.21 -0.48
14.3
14.0
12.0
0.042 0.030
NEFTIS2
PSV14 PEEP8
*
*
*
*
*
*
*
*
SMARTAIR leak circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
SMARTAIR simple circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
SYNCHRONY
PSV14 PEEP8
*
*
*
*
*
*
*
*
SYNCHRONY2
PSV14 PEEP8
*
*
*
*
*
*
*
*
VIVO40
PSV14 PEEP8
*
*
*
*
*
*
*
*
VPAP3ST
PSV14 PEEP8
*
*
*
*
*
*
*
*
VPAP3STA
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS INTEGRA leak circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS INTEGRA simple circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS SERENA
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS ULTRA double circuit flow trigger
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS ULTRA leak circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS ULTRA simple circuit
PSV14 PEEP8
*
*
*
*
*
*
*
*
VS UTRA double circuit pressure trigger PSV14 PEEP8
*
*
*
*
*
*
*
*
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or autotriggering.
1autotriggering
2autotriggering
for a leak of 2.6L/min
for a leak of 6L/min, the ventilator requires a back up rate slightly below the spontaneous breathing
Ventilator which does not have a compatible mode: EOLE3XLS
Table 5: Patient 5 with vocal cord paralysis
Ventilators
Setting
PSV14 PEEP8
ELYSEE150 double circuit1
2
PSV14 PEEP8
ELYSEE150 simple circuit
3
PSV14 PEEP8
GK425ST
4
PSV14 PEEP8
HARMONY2
5
PSV14 PEEP8
iSLEEP22
6
PSV14 PEEP8
KNIGTSTAR330
LEGENDAIR7
PSV14 PEEP8
8
PSV14 PEEP8
NEFTIS2
PSV14 PEEP8
SMARTAIR leak circuit
PSV14 PEEP8
SMARTAIR simple circuit
PSV14 PEEP8
SYNCHRONY9
9
PSV14 PEEP8
SYNCHRONY2
PSV14 PEEP8
VIVO4010
11
PSV14 PEEP8
VPAP3ST
12
PSV14 PEEP8
VPAP3STA
PSV14 PEEP8
VS INTEGRA leak circuit
13
PSV14 PEEP8
VS INTEGRA simple circuit
14
PSV14 PEEP8
VS SERENA
PSV14 PEEP8
VS ULTRA double circuit flow trigger
PSV14 PEEP8
VS ULTRA leak circuit
PSV14 PEEP8
VS ULTRA simple circuit15
16
VS UTRA double circuit pressure trigger PSV14 PEEP8
Peep
(cmH2O)
8.6
6.7
7.5
8.1
8.3
8.3
8.1
7.5
*
*
8.2
8.0
8.0
7.8
7.8
*
7.2
7.7
*
*
8.8
9.0
Pmax Pressurisation
PS
VTm
T
P
ventilator
slope
(L)
(s) (cmH2O)(cmH2O)
(cmH2O)
(cmH20/s)
0.289 -1.94
13.9
14.0
24.4
0.242
0.246 -1.61
14.1
14.0
34.5
0.260
0.127 -0.21
13.6
14.0
23.7
0.294
0.128 -0.25
14.0
14.0
34.7
0.323
0.073 -0.54
14.5
15.0
12.2
0.285
0.061 -0.44
14.9
14.0
25.1
0.349
0.095 -1.24
14.4
14.0
8.2
0.303
0.073 -1.17
13.4
14.5
17.1
0.294
*
*
*
*
*
*
*
*
*
*
*
*
0.119 -0.58
14.2
14.0
36.6
0.305
0.138 -1.01
14.3
14.0
36.1
0.330
0.210 -0.60
13.6
14.0
19.5
0.250
0.170 -0.23
14.0
14.0
39.3
0.313
0.112 -0.21
14.2
14.0
44.4
0.313
*
*
*
*
*
*
0.059 -0.69
13.9
14.0
37.4
0.340
0.1
-0.4
14.1
14.0
35.5
0.327
*
*
*
*
*
*
*
*
*
*
*
*
0.1
-1.1
15.0
14.0
51.7
0.3
0.1
-1.2
14.8
14.0
50.4
0.3
VTv
(L)
0.233
0.262
No ind.
No ind.
No ind.
0.373
0.278
0.245
*
*
0.262
0.262
0.160
0.312
0.322
*
0.405
0.320
*
*
0.3
0.3
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or autotriggering.
1autotriggering
for a leak of 52L/min
for a leak of 6L/min
3pressure support falls to 12.7 cm H O when leak > 114L/min
2
4alarm for a leak of 79L/min and pressure support falls to 13.7 cm H O
2
5autotriggering for a leak of 26L/min
6autotriggering for a leak of 5L/min
7alarm for a leak of 6L/min, the ventilator requires a back up rate slightly below the spontaneous breathing
8autotriggering for a leak of 6L/min
9pressure support falls to 11 cm H O when leak > 120L/min
2
10autotriggering for a leak of 28L/min, and does not detect the inspiratory effort when used with a humidifier
11alarm for a leak of 50L/min and pressure support falls to 14.2 cm H O and PEEP to 6.8 cm H O
2
2
12alarm for a leak of 42L/min and pressure support falls to 14.2 cm H O and PEEP to 6.9 cm H O
2
2
13autotriggering for any leak
14autotriggering for a leak of 20L/min
15autotriggering for a leak of 15L/min
16autotriggering for a leak of 7.5L/min
2autotriggering
Ventilator which does not have a compatible mode: EOLE3XLS
Table 6: Patient 6 with central apnea
Ventilators
ELYSEE150 double circuit1
ELYSEE150 simple circuit
LEGENDAIR2
NEFTIS23
SMARTAIR simple circuit4
VS INTEGRA simple circuit
VS ULTRA double circuit flow trigger
VS ULTRA simple circuit
VS UTRA double circuit pressure trigger5
Pmax
Pressurisation
PEEP T
PS
P
Setting
ventilator
slope
VTm (L)
(cmH2O) (s) (cmH2O)(cmH2O)
(cmH2O)
(cmH2O/s)
PSV12 ZEEP 0.23 0.18 -1.03
12.3
12.0
83.7
0.26
PSV12 ZEEP
*
*
*
*
*
*
*
PSV12 ZEEP 0.55 0.15 -0.97
12.1
12.0
7.4
0.85
PSV12 ZEEP 0.97 0.15 -1.80
6.2
13.0
16.4
0.36
PSV12 ZEEP 0.23 0.08 -0.36
12.1
13.0
7.8
1.02
PSV12 ZEEP
*
*
*
*
*
*
*
PSV12 ZEEP
*
*
*
*
*
*
*
PSV12 ZEEP
*
*
*
*
*
*
*
PSV12 ZEEP 0.47 0.13 -1.50
13.0
12.0
96.0
1.12
VTv (L)
0.65
*
0.83
0.31
1.03
*
*
*
1.01
Abbreviations: PEEP: positive end-expiratory pressure, T: trigger time delay, P: trigger pressure, PS: pressure support, Pmax:
maximal inspiratory pressure delivered by the ventilator, VTm: measured tidal volume, VTv: tidal volume measured by the ventilator,
ZEEP: zero end-expiratory pressure, ACV: assist control ventilation.
Values reported in this table were obtained when the leak valve (Figure1) was closed. Effects of a leak simulated with the leak valve
are indicated in the footnotes
* does not detect the inspiratory effort or autotriggering.
1does
not detect the patient’s inspiratory effort or autotriggering for a leak of 8L/min
for a leak of 2.3L/min, the ventilator requires a back up rate slightly below the spontaneous breathing
3alarm “disconnected circuit, patient compliance” + autotriggering for a leak of 10L/min,
4autotriggering for a leak of 1.5L/min
5autotriggering for a leak of 24L/min and does not detect the patient’s inspiratory effort with a humidificator
2autotriggering
Ventilators which do not have a compatible mode: EOLE3XLS, GK425T, HARMONY2, iSLEEP22, KNIGHTSTAR330, SMARTAIR +
leak circuit, SYNCHRONY and SYNCHRONY2, VIVO40, VPAP3ST, VPAP3STA, VS SERENA, VS ULTRA + leak circuit
Table 7: Testing of the quality of the expiratory triggers by the difference between the patient’s inspiratory time during spontaneous
breathing (Tinsp) and the inspiratory time during mechanical ventilation (T I).
Tinsp-TI (s)
Ventilators
patient # 1 patient # 2 patient # 3 patient # 4 patient # 5 patient # 6
ELYSEE150 double circuit
*
0.04
0.12
*
0.35
-0.32
ELYSEE150 simple circuit
*
0.05
0.21
*
0.40
*
GK425ST
na
na
na
*
0.21
na
HARMONY2
na
na
na
*
0.09
na
iSLEEP22
na
na
na
*
0.27
na
KNIGTSTAR330
na
na
na
0.00
0.20
na
LEGENDAIR
0.05
0.06
0.14
-0.09
0.18
-0.34
NEFTIS2
-0.23
-0.23
-0.12
*
-0.08
-0.06
SMARTAIR leak circuit
na
na
na
*
*
na
SMARTAIR simple circuit
*
*
-0.05
*
*
*
SYNCHRONY
na
na
na
*
0.25
na
SYNCHRONY2
na
na
na
*
0.05
na
VIVO40
na
na
na
*
0.39
na
VPAP3ST
na
na
na
*
0.27
na
VPAP3STA
na
na
na
*
0.07
na
VS INTEGRA leak circuit
na
na
na
*
*
na
VS INTEGRA simple circuit
*
*
*
*
0.40
*
VS SERENA
na
na
na
*
-0.23
na
VS ULTRA double circuit flow trigger
0.02
-0.05
0.14
*
*
*
VS ULTRA leak circuit
na
na
na
*
*
na
VS ULTRA simple circuit
*
-0.11
0.08
*
0.48
*
VS UTRA double circuit pressure trigger
*
*
0.00
*
0.48
-0.52
Abbreviations: na: not applicable. This parameter was only calculated for pressure-targeted ventilators.