LINSTEDT LAB
DEPT OF BIOLOGICAL SCIENCES
CARNEGIE MELLON UNIVERSITY
4400 5TH AVENUE
PITTSBURGH, PA 15213
linstedt@cmu.edu
PUBLICATIONS

Sengupta, D. and Linstedt, A.D. (2010). Mitotic inhibition of GRASP65 organelle tethering involve
Polo-like kinase 1 (PLK1) phosphorylation proximate to an internal PDZ ligand. J Biol Chem. [Epub
ahead of print].

Bachert, C. and Linstedt, A.D. (2010). “Dual anchoring of the GRASP membrane tether promotes tran
pairing. J Biol Chem. 285: 16294-16301.

Mukhopadhyay, S., Bachert, C., Smith, D. and Linstedt, A.D. (2010). Manganese-induced trafficking
and turnover of the cis Golgi glycoprotein GPP130. Mol. Biol. of the Cell, 21: 1282-1292.

Gong, H., Guo, Y., Linstedt A.D. and Schwartz, R. (2010). Discrete, continuous and stochastic model
of protein sorting in the Golgi. Phys Rev E, in press.

S. Emr, B.S. Glick, A.D. Linstedt, J. Lippincott-Schwartz, A. Luini, V. Malhotra, B.J. Marsh, A
Nakano, S.R. Pfeffer, C. Rabouille, J.E. Rothman, G. Warren, and F.T. Wieland (2009). Journey
through the Golgi—taking stock in a new era. J. Cell Biol. 187: 449-53.

Sengupta, D., Truschel, S., Bachert, C. and Linstedt, A.D. (2009). Organelle tethering by a homotypic
PDZ interaction underlies formation of the Golgi membrane network. J. Cell Biol. 186:51-55.

Srinivasa, G., Fickus, M.C, Guo, Y., Linstedt A.D. and Kovačević J. (2009). Active mask segmentation
of fluorescence microscope images. IEEE Trans Image Process. 18(8):1817-29.

Yadav, S., Puri, S., and Linstedt, A.D. (2009). A Primary Role for Golgi Positioning in Directed
Secretion, Cell Polarity and Wound Healing. Mol. Biol. of the Cell 20:1728-1736.

Gong, H. Sengupta, D., Linstedt A.D. and Schwartz, R. (2008). Simulated de novo assembly of Golg
compartments by selective cargo capture during vesicle budding and targeted vesicle fusion. Biophys
J., 95: 1674–1688.

Feinstein, NT, and Linstedt, A.D. (2008). GRASP55 regulates Golgi ribbon formation. Mol. Biol. o
the Cell, 19:2696–2707.

Guo, Y., Punj, V. Sengupta, D. and Linstedt, A.D. (2008). Coat-tether interaction in Golgi organization
Mol. Biol. of the Cell, 19, 2830–2843.

Srinivasa, G., Fickus, M., Gonzalez-Rivero, Hsieh S., Guo, Y., Linstedt, A.D. and Kovacevic, J. (2008)
Active-mask segmentation for the cell-volume computation and Golgi-body segmentation of HeLa cel
images. Proc. IEEE Intl. Symp. Biomed. Imaging, Paris, France, May 2008, pp. 348-351.

Bachert, C., Fimmel, C.J., and Linstedt, A.D. (2007).
produces marker for liver disease. Traffic 8:1415-23.

Feinstein, T. and Linstedt, A.D. (2007). Mitogen-activated Protein Kinase Kinase-dependent Golg
Unlinking Occurs in G2 phase and Promotes the G2/M Cell Cycle Transition. Mol. Biol. of the Cell
18:594-604.

Guo, Y. and Linstedt, A.D. (2006). COPII-Golgi Protein Interactions Regulate COPII Coat Assembly
and Golgi size. J. Cell Biol. 174:53-63.

Puthenveedu, M.A., Bachert, C., Puri, S., Lanni, F. and Linstedt, A.D. (2006). GM130 and GRASP65
dependent lateral cisternal fusion confers uniform Golgi enzyme distribution. Nature Cell Bio., 8: 238
248.

Puthenveedu, M.A., Linstedt, A.D. (2005) Subcompartmentalizing the Golgi Apparatus, Curr. Opin
Cell Bio. 17: 369–375.

Natarajan, R. and Linstedt, A.D. (2004). A cycling cis Golgi protein mediates endosome-to-Golg
traffic. Mol. Biol. of the Cell 15: 4798–4806.

Linstedt, A.D. (2004). Positioning the Golgi Apparatus. Cell 118: 271-272.

Puthenveedu, M.A., and Linstedt, A.D. (2004). Gene replacement reveals that p115/SNARE interaction
are essential for Golgi biogenesis. Proc. Natl. Acad. Sci. USA 101: 1253-1256 (direct track I
submission).

Puri, S., Telfer, H., Velliste, M., Murphy, R., and Linstedt, A.D. (2004). Dispersal of Golgi matrix
proteins during mitotic Golgi disassembly. J. Cell Sci. 117:451-456.

Puri, S. and Linstedt, A.D. (2003). Capacity of the Golgi Apparatus for Biogenesis from the
Endoplasmic Reticulum. Mol. Biol. of the Cell 14:5011-5018.

Puthenveedu, M.A., Weisz, O.A. Linstedt, A.D. (2003). Basolateral cycling mediated by a lumena
domain targeting determinant. Mol. Biol. of the Cell 14:1801-1807.

Puri, S., Bachert, C., Fimmel, C.J., and Linstedt, A.D. (2002). Cycling of early Golgi proteins via the
cell surface and endosomes upon lumenal pH disruption. Traffic 3:641-653.

Puthenveedu, M.A., and Linstedt, A.D. (2001). In search of an essential step during mitotic Golg
disassembly and inheritance. Exp. Cell. Res. 271: 22-27.

Jesch, S.A., Mehta, A.J, Velliste, M., Murphy, R., and Linstedt, A.D. (2001). Mitotic Golgi is in a
dynamic equilibrium between clustered and free vesicles, that are independent of the ER. Traffic 2:873
884.

Puthenveedu, M.A., and Linstedt, A.D. (2001). Evidence that Golgi structure depends on a p115
activity that is independent of the vesicle tether components giantin and GM130. J. Cell Biol. 155: 227
Furin cleavage of cis-Golgi protein GP73
237.

Bachert, C., Lee, T.H., and Linstedt, A.D. (2001). Lumenal endosomal and Golgi-retrieval determinant
involved in pH-sensitive targeting of an early Golgi protein. Mol. Biol. of the Cell 12: 3152-3160.

Jesch, S.A., Lewis, T.S., Ahn, N.G., and Linstedt, A.D. (2001). Mitotic phosphorylation of Golg
reassembly stacking protein 55 by mitogen activated protein kinase ERK2. Mol. Biol. of the Cel
12:1811-1817.

Lee, T.H., and Linstedt, A.D. (2000) Potential role for protein kinases in regulation of bidirectiona
endoplasmic reticulum-to-Golgi transport revealed by protein kinase inhibitor H89. Mol. Biol. of the
Cell 11: 2577-2590.

Linstedt, A.D., Jesch, S.A., Mehta, A, Lee, T.H., Garcia-Mata, R., Nelson, D.S., and Sztul, E. (2000)
Binding relationships of membrane tethering components: the giantin N-terminus and the GM130 N
terminus compete for binding to the p115 C-terminus. J. Biol. Chem. 275(14), 10196-10201.

Linstedt, A. D., and Hauri, H.-P. (1999). Giantin, in Guidebook to the Cytoskeletal and Motor Proteins
eds. Kreis, T. and Vale R., Oxford Univ. Press.

Linstedt, A. D. (1999). Golgi complex: Stacking the cisternae. Current Biology 9, R897-R898.

Lee, T.H., and Linstedt, A. D. (1999). Osmotically induced cell volume changes alter anterograde and
retrograde transport, organelle structure, and COPI membrane dissociation. Mol. Biol. of the Cell. 10
1445-1456.

Jesch, S.A., and Linstedt, A.D. (1998). The Golgi and endoplasmic reticulum remain independen
during mitosis in HeLa cells. Mol. Biol. of the Cell. 9, 623-635.

Linstedt, A. D., Mehta, A., Suhan, J., Reggio, H., and H. -P. Hauri. (1997). Sequence and
overexpression of GPP130/GIMPc: evidence for saturable pH-sensitive targeting of a type II early Golg
membrane protein. Mol. Biol. of the Cell 8, 1073-1087.