LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
THIRD SEMESTER – November 2008
ED 33
BT 3814 - BIOSTATISTICS AND BIOINFORMATICS
Date : 07-11-08
Time : 9:00 - 12:00
Dept. No.
Max. : 100 Marks
PART A (20x1= 2))
Answer all the questions
I Choose the best answer:
(5 x 1 =5)
1.A Network portal for databases
a) SRS
b)STS
c)SGS
d)SAS
2. Taxon ID for Homo sapiens is
a)9606
b)9601
c)9106
d)9101
3.Software for analyzing gene structure is
a)GEO
b)Genscan
c)Prosite
d)PRINTS
4. The observation which more often than others is called as
a) Mean
b) Median
c) Mode
d) Range
5. The probability of one set of dichotomous alternative is distribution of
a) Binomial b) Poison
c) Normal
d) kurtosis
II State whether the following True or False:
(5 x 1 =5)
6.CpG is rich in genefree regions
7.An example of IP address is 192.168.50.1
8.Protein domains and motifs are conserved regions identified by PIR
9. Positional average in a given population is called as mean.
10. Effect of heavy metals on microbes can be positively correlated.
III Complete the following
(5 x 1 =5)
11.--------------- translates sequence in six frames
12.Software for identifying restriction sites of any unknown sequence is --------.
13.Atomic coordinate file can be retrieved from -----------.
14. Estimation of the value of one variable from the given value of another is -------.
15. Ratio of variance between samples and variance within the sample is -----------.
IV Answer the following, each not exceeding 50 words.
(5 x 1 =5)
16.Expand and explain PANDIT.
17.Differentiate Clustal W and Clustal X.
18.What sequence of aminoacid will follow the RNA sequence code if translated by a
ribosome in human?
5” AUG GGA UGU CGC CGA AAC 3”
19. Define Coefficient of variation.
20. What is Level of significance
PART – B
Answer any 5 of the following, choose not more than 3 in each section.
Each answer not exceeding 350 words (8x5= 40 marks)
Draw diagrams / flow charts wherever necessary.
Section I
21. Draw a phylogenetic tree using Distance based method for the given data
A
B
C
D
1
A
0
B
8
0
C
7
9
0
D
12
14
11
0
22.Explain any four protein structure prediction approaches
23.Write about genomic tools with examples
24.Discuss about BLAST its parameters, types and applications
Section II
25. Obtain mean, median and mode for the following data.
No. of wasps/colony 2
3
4
5
6
7
8
No. of colonies
4
6
8
12
7
7
6
26.The following data gives the yield of maize grain (in Kg) per plot of size 10 x 4 sq m. for different
doses of nitrogen applications. Calculate the correlation coefficient and draw your inferences.
Amount of N (kg/plot)
20
30
50
90
100
Yield of maize (g)
27. Explain briefly what do you understand by the normal curve? What are its important properties
and applications?
28. Explain sampling techniques in biological studies.
PART - C
Answer the following, each not exceeding 1500 words.
Draw diagrams / flow charts wherever necessary (2x20=40 marks)
30. a)Elaborate upon Drug discovery and designing
Or
30 b) Discuss about protein signature prediction by defining Domain Family and
Signature .List the databases from which the details can be retrieved
31. a) Apply one way analysis of variance test to the following data on plankton density in ponds A,
B, C and D and find out whether the variance in the density of planktons in different ponds is significant.
Density (mg / L)
A
B
C
D
16
23
29
33
18
22
24
29
20
26
32
36
30
32
35
41
32
36
36
44
Or
31. b) The ESR (erythrocyte) sedimentation rate (mm /hr) of 10 male and 7 female are given below.
Calculate the significance of the difference in the means.
Males
71
63
64
105
85
45
107
Females
58
64
92
105
97
100
130
**************
2
120
83
70