LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIO TECHNOLOGY
FIRST SEMESTER – APRIL 2012
BT 1821 - CELL AND MOLECULAR BIOLOGY
Date : 19-04-2012
Time : 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART – A
ANSWER ALL THE QUESTIONS
I. Choose the correct answer:
(5 x 1 = 5 marks )
1) Crossing over occurs in which stage of meiosis I?
a) Pachytene
b) Diakinesis
c) Leptotene
d) Zygotene
2) Where does transcription occur in a eukaryotic cell?
a) Cytoplasm b) Nucleus c) Endoplasmic reticulum
d) Mitochondria
3) Heterochromatin is
a) highly condensed and code for proteins
b) highly condensed and does not code for protein
c) not condensed and codes for proteins
d) lightly condensed and code for protein
4) Receptor is always a
a) protein b) carbohydrate
5) Who is the father of heredity?
a) Charles Darwin b) Bateson
c) lipid
d) amino acid
c) Dobshansky d) Greger Mendel
II. State whether the following are True or False;if false give reason:
(5 x 1 = 5 marks )
6) Size of microfilament is 3-6 nm.
7) RNA pol II is involved in tRNA synthesis .
8) Euchromatin is present in the centromeric DNA .
9) Paracrine signaling occurs between cells.
10) Phenotypic ratio of monohybrid cross is 9:2:2:1.
III. Complete the following:
(5 x 1 = 5 marks )
11) The amount of DNA present in human diploid cell is ________pg.
12) The initiation codon for eukaryote is ______ .
13) Enhancer in eukaryote is a __________element.
14) Pinocytosis is the internalization of _______________ particles.
15) Quantitative inheritance is also called as__________ and _________ .
IV. Answer the following each in about 50 words only:
(5 x 1 = 5 marks)
16) Define cytoskeleton.
17) What is a chaperone?
18) What is codon bias?
19) Define phagocytosis.
20) Give the alternative name for panmixis and define it.
PART - B
Answer the following in about 500 words only; Draw diagrams wherever necessary:
( 5 x 8 = 40 marks)
21 a) Enlist the modern version of cell theory.
OR
b) Write an account of extracellular matrix.
22 a) Explain the galactose metabolism in yeast.
OR
b) Give an account of various RNA processing events.
23 a) What are all the characteristics of Genetic code?
OR
b) Briefly comment on site specific recombination.
24 a) What is signal transduction? Explain the enzyme linked mode of it with diagram .
OR
b) Give a brief account of electron transport chain
25 a) Distinguish between quantitative and qualitative inheritances with two
examples each.
OR
b) Write a short note on myogenesis in Drosophila.
PART – C
Answer any TWO of the following, each in about 1500 words only; Draw diagrams where
necessary:
( 2x 20 = 40 marks)
26) Describe cell cycle and its check points.
27)
Write notes on
i)
Transcriptional activator proteins
ii)
Eukaryotic transcription factors
iii)
Active and passive transport
28) Explain chromatin organization with diagrams and write the genetic
codes of eukaryotes .
29) List out evidences for cytoplasmic inheritance factors? Describe the mechanism of extranuclear
inheritance in Paramecium.
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