LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034
M.Sc. DEGREE EXAMINATION - BIOMED.INSTRUMENTATION SC.
FOURTH SEMESTER – APRIL 2012
BI 4954 - BIOMEDICAL INFORMATICS
Date : 23-04-2012
Time : 1:00 - 4:00
Dept. No.
Max. : 100 Marks
PART A
Answer ALL questions:
(10 x 2=20 marks)
1. Define Cheminformatics.
2. Comment on dendrogram.
3. Give a note on DDBJ.
4. What is gapped blast?
5. Enumerate the activities of EMBnet.
6. What are web browsers? Give two examples.
7. Write a note on Orthology and Paralogy.
8. What is Genome scan?
9. Write a note on PILEUP.
10.What is motif?
PART B
Answer any FOUR of the following:
(4×10=40 marks)
11. Write short notes on Comment on CATH and SCOP.
12. Give a detailed account of FASTA.
13. Explain Multiple Sequence Alignment and its significance.
14. Write notes on DNA sequence databases.
15. Give an account on analysis packages.
16. Explain Kyoto Encyclopedia of Genes and Genomes (KEGG).
PART C
Answer any TWO of the following:
(2×20=40 marks)
17. Explain global and local alignment progammes.
18. Describe protein structure visualization tools and their features.
19. Describe the various ways to identify lead compound? Describe the steps involved in the
development of a new drug.
20. Explain Phylogenetic analysis and construction of phylogenetic tree.
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