NAME_______________________________
VIROLOGY
TEST #3, SAMPLE
R. H. REEVES
THE FIRST TWENTY QUESTIONS ARE WORTH TWO POINTS EACH.
THERE IS ONLY ONE
CORRECT ANSWER.
PLEASE CIRCLE THE CORRECT LETTER OR PLACE THE CORRECT
LETTER JUST TO THE LEFT OF THE QUESTION NUMBER.
1.
THESE TWO RNA VIRUSES DO NOT HAVE LIPID ENVELOPES
A.
HEPATITIS A VIRUS
AND MEASLES VIRUS
B.
COXSACKIE A VIRUS
AND INFLUENZA C VIRUS
C.
HUMAN CORONA VIRUS
AND RUBELLA VIRUS
D.
POLIOVIRUS-1
AND COLORADO TICK FEVER VIRUS
E.
MUMPS VIRUS
AND RUBELLA VIRUS
2.
THIS VIRUS HAS A DOUBLE-STRANDED GENOME WHICH IS CAPPED ON ONE
5’-END.
A.
LASSA FEVER VIRUS
B.
HUMAN ROTAVIRUS
C.
HEPATITIS A VIRUS
D.
MUMPS VIRUS
E.
INFLUENZA A VIRUS
3.
CIRCULARIZED SINGLE-STRANDED RNA IS FOUND IN THE VIRION OF
A.
HEPATITIS A VIRUS
B.
INFLUENZA A VIRUS
C
BUNYAMWERA VIRUS
D.
EASTERN EQUINE ENCEPHALITIS VIRUS
E.
ROUS SARCOMA VIRUS
4.
THE GENE ORDER OF ROUS SARCOMA VIRUS IS
A.
gag env pol src
B.
src gag env pol
C.
env pol gag src
D.
pol gag src env
E.
gag pol env src
5.
THE GENOMIC RNA OF POLIOVIRUS TYPE 3
A.
SERVES AS A MESSENGER RNA
B.
HAS A 5' CAP
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
6.
THE VIRUS FAMILY THAT HAS AN AMBISENSE GENOME IS
A.
REOVIRIDAE
B.
ARENAVIRIDAE
C.
BOTH OF THE ABOVE
D.
NEITHER OF THE ABOVE
MICROBIOLOGY
TEST #3
PAGE 3
KEY FOR QUESTIONS 14-28. THERE IS ONLY ONE CORRECT ANSWER BUT EACH KEY WORD
MAY BE USED MORE THAN ONCE.
A.
B.
C.
D.
E.
F.
G.
I.
EASTERN EQUINE ENCEPHALITIS VIRUS
RHINOVIRUS TYPE 23
MEASLES (RUBEOLA) VIRUS
ROTAVIRUS
LASSA FEVER VIRUS
INFLUENZA A VIRUS
ROUS SARCOMA VIRUS
RABIES VIRUS
_____14.
ITS M2 PROTEIN INTERACTS WITH AMANTIDINE
_____15.
ITS CLOSE RELATIVE IS THE TARGET OF THE SALK VACCINE
_____16.
ITS ONCOGENE IS A PROTEIN KINASE
_____17.
THE CURRENT PEDIATRIC VACCINE FOR THIS VIRUS USES AN
ATTENUATED VIRUS
_____18.
THE MAJOR CAUSE OF INFANTILE GASTROENTERITIS
_____19.
ESTABLISHES “LATENCY” IN NERVOUS TISSUE
_____20.
HORSES AND MAN ARE “DEAD END” HOSTS
(SSPE)
**********************************************
21.
EXPLAIN
WHY
THE
CELLULAR
ONCOGENES
(C-0NCs)
THAT
HAVE
BEEN
CHARACTERIZED ALWAYS HAVE INTRONS, WHEREAS THE ONCOGENES THAT HAVE
BEEN FOUND IN RNA TUMOR (SARCOMA) VIRUSES (V-ONCs) HAVE ANALOGOUS
CODING SEQUENCES BUT NEVER HAVE INTRONS.
22.
THE MONONEGAVIRALES
MECHANISM. EXPLAIN.
23.
THE REPLICATION OF INFLUENZA VIRUS IS EFFECTIVELY INHIBITED BY THE
DRUG ALPHA-AMINITIN, WHICH STRONGLY INHIBITS THE HOST ENZYME RNA
POLYMERASE II. THIS DRUG, HOWEVER, HAS LITTLE EFFECT ON THE
REPLICATION OF OTHER RNA VIRUSES. EXPLAIN.
VIRUSES
MAKE
THEIR
mRNAs
BY
A
“STUTTERING”