NAME___________________________________
MCB 2004, MICROBIOLOGY
TEST #3-A, APRIL 08, 2009
R. H. REEVES
IN THIS SECTION THERE ARE FORTY QUESTIONS WORTH TWO POINTS EACH.
THERE IS ONLY ONE CORRECT ANSWER FOR EACH QUESTION. PLEASE CIRCLE
THE CORRECT LETTER OR PLACE THE CORRECT LETTER JUST TO THE LEFT OF
THE QUESTION NUMBER. THEN TRANSFER ALL YOUR ANSWERS TO THE ANSWER
SHEET.
KEY FOR QUESTIONS 1-5. THERE IS ONLY ONE CORRECT ANSWER BUT EACH
KEY WORD MAY BE USED MORE THAN ONCE.
A.
B.
C.
D.
E.
TETRACYCLINE
DAPSONE & RIFAMPIN
CEPHALOSPORIN
TRIMETHOPRIM
CIPROFLOXICIN
D_____1.
USED WITH SULFAMETHOXAZOLE FOR URINARY TRACT INFECTIONS
E_____2.
THIS DNA GYRASE INHIBITOR IS USED FOR ANTHRAX
A_____3.
THIS DRUG BINDS TO PROTEINS OF THE 30S RIBOSOMAL SUBUNIT
B_____4.
THE PRESCRIPTION FOR LEPROSY
C_____5.
THIS DRUG IS INACTIVATED BY A -LACTAMASE
6.
HE DEVELOPED THE MAGIC BULLET CONCEPT AND IS CALLED THE FATHER
OF CHEMOTHERAPY
A.
ALEXANDER FLEMMING
B.
FRANCIS CRICK
C.
LOUIS PASTEUR
D.* PAUL ERLICH
E.
JONAS SALK
7.
BY ACCIDENT HE DISCOVERED THE PENICILLINS
A.* ALEXANDER FLEMMING
B.
FRANCIS CRICK
C.
LOUIS PASTEUR
D.
PAUL ERLICH
E.
JONAS SALK
MCB 2004
TEST #3-A
PAGE 2
8.
A TOXIN PRODUCED BY STAPHYLOCOCCUS AUREUS CAUSES
A.
LOCK JAW
B.
FLACCID PARALYSIS
C.
BOTH OF THE ABOVE
D.* NEITHER OF THE ABOVE
9.
TWO BACTERIA ASSOCIATED MOST CLOSELY WITH CHILDHOOD SEPTIC
MENINGITIS ARE
A.* HAEMOPHILUS INFLUENZAE AND STREPTOCOCCUS PNEUMONIAE
B.
STREPTOCOCCUS PYOGENES AND STAPHYLOCOCCUS AUREUS
C.
NEISSERIA MENINGITIDIS AND LISTERIA MONOCYTOGENES
D.
MYCOBACTERIUM TUBERCULOSIS AND HAEMOPHILUS INFLUENZAE
E.
PSEUDOMONAS AERUGINOSA AND KLEBSIELLA PNEUMONIAE
KEY FOR QUESTIONS 10-14. THERE IS ONLY ONE CORRECT ANSWER BUT EACH
KEY WORD MAY BE USED MORE THAN ONCE.
A.
B.
C.
D.
E.
DENGUE FEVER VIRUS
RABIES VIRUS
HUMAN CORONAVIRUS
RESPIRATORY SYNCYTIAL VIRUS
HERPES SIMPLEX VIRUS-1
B_____10. CAUSES A FATAL ENCEPHALITIS OF MAMMALS
E_____11. CAUSES LATENT AND RECURRENT INFECTIONS
A_____12. AN INSECT BITE TRANSMITS IT, THE CAUSE OF "BREAK-BONE"
FEVER
C_____13. A COMMON COLD VIRUS (AND RECENTLY IMPLICATED IN "SARS")
D_____14. FOR MANY YEARS IT HAS BEEN THE CAUSE OF A SERIOUS LOWER
RESPIRATORY TRACT INFECTION IN INFANTS
15.
THIS
A.
B.*
C.
D.
E.
VIRUS IS NOT ASSOCIATED WITH RESPIRATORY TRACT DISEASE
RESPIRATORY SYNCYTIAL VIRUS
POLYOMAVIRUS
CORONAVIRUS
RHINOVIRUS
INFLUENZA VIRUS B
MCB 2004
TEST #3-A
PAGE 3
16.
THE TWO PEDIATRIC TOXOID VACCINES PREVENT
A.
TETANUS AND CHOLERA
B.
BOTULISM AND CHOLERA
C.* TETANUS AND DIPHTHERIA
D.
BOTULISM AND DIPHTHERIA
E.
CHOLERA AND DIPHTHERIA
17.
FOOD POISONING THAT CAUSES LOWER GI SYMPTOMS WITH INCUBATION
PERIODS UP TO 24 HOURS IS USUALLY CAUSED BY
A.
STAPHYLOCOCCUS AUREUS
B.
BACILLUS CEREUS
C.
VIBRIO PARAHAEMOLYTICUS
D.* CLOSTRIDIUM PERFRINGENS
E.
ESCHERICHIA COLI
18.
YERSINIA PESTIS IS TRANSMITTED TO HUMANS BY
A.
A DOG BITE
B.* A FLEA BITE
C.
A MOSQUITO BITE
D.
A TICK BITE
E.
A RAT BITE
KEY FOR QUESTIONS 19-24. THERE IS ONLY ONE CORRECT ANSWER, BUT
EACH ANSWER MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
B.
C.
D.
E.
TOXIC SHOCK SYNDROME
YELLOW FEVER
GLOMERULONEPHRITIS
DIPHTHERIA
LYME DISEASE
B_____19. IT IS TRANSMITTED BY MOSQUITOES
D_____20. CHARACTERIZED BY PRODUCTION OF A "PSEUDOMEMBRANE"
A_____21. DUE TO A TOXIN OF STAPHYLOCOCCUS AUREUS
E_____22. LATE SYMPTOMS INCLUDE NEUROLOGICAL PROBLEMS AND ARTHRITIS
E_____23. SYMPTOMS INCLUDE A "BULL'S EYE" RASH
B_____24. THE AGENT OF THIS DISEASE IS A VIRUS
MCB 2004
TEST #3-A
PAGE 4
25. ALL OF THE FOLLOWING INHIBIT PROTEIN BIOSYNTHESIS EXCEPT
A.
CHLORAMPHENICOL
B.
TETRACYCLINE
C.* VANCOMYCIN
D.
ERYTHROMYCIN
E.
STREPTOMYCIN
26.
MARY EXPERIENCES STOMACH CRAMPS AND VOMITING 3 HOURS AFTER
EATING A CREAM PUFF AT A NEW YORK PASTRY SHOP. SHE PROBABLY
HAS
A.
BOTULISM TOXINOSIS
B.
CLOSTRIDIAL FOOD POISONING
C.
SALMONELLOSIS
D.
BACILLARY DYSENTERY
E.*
STAPHYLOCOCCAL FOOD POISONING
27.
IT’S THE CAUSE OF A TICK-BORNE FEVER AND WHOLE BODY RASH THAT
CAN OFTEN LEAD TO COMA
A.
TREPONEMA PALLIDUM
B.
CHLAMYDIA PSITTASI
C.
LISTERIA MONCYTOGENES
D.
BORRELIA BURGDORFERI
E.* RICKETTSIA RICKETTSII
KEY FOR QUESTIONS 28-32. EACH QUESTION HAS ONLY ONE ANSWER, BUT
EACH ANSWER MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
B.
C.
D.
E.
STREPTOCOCCUS PYOGENES
STAPHYLOCOCCUS AUREUS
LISTERIA MONOCYTOGENES
STREPTOCOCCUS MUTANS
BACILLUS CEREUS
C_____28. IT CROSSES THE PLACENTA AND CAUSES STILLBIRTHS
A_____29. ITS INFECTION MAY RESULT IN SCARLET FEVER
B_____30. CAUSES BOILS
E_____31. ITS SPORES SURVIVE COOKING AND CAUSE FOOD POISONING
D_____32. ITS RESPONSIBLE FOR BIOFILM INVOLVED IN DENTAL CARIES
MCB 2004
TEST #3-A
PAGE 5
33.
THIS DISEASE IS DIAGNOSED (IN PART) BY OBSERVING GHON
COMPLEXES IN THE LUNGS
A.
WHOOPING COUGH
B.
PNEUMONIA
C.* TUBERCULOSIS
D.
INFLUENZA
E.
PLEURISY
34.
NEISSERIA GONORRHOEAE
A.
IS A GRAM POSITIVE, SLENDER ROD
B.
CAUSES A SECONDARY DISSEMINATED (WHOLE BODY)SKIN RASH
C.
IS KEPT IN CHECK BY A TOXOID VACCINE
D.
MAKES A TOXIN THAT INHIBITS PROTEIN SYNTHESIS
E.* CAN CAUSE PELVIC INFLAMMORATORY DISEASE
35.
THIS
A.*
B.
C.
D.
VIRUS CAUSES LIVER DISEASE TRANSMITTED BY FOOD AND WATER
HEPATITIS A VIRUS
HEPATITIS B VIRUS
HEPATITIS C VIRUS
NONE OF THE ABOVE
KEY FOR QUESTIONS 36-40. EACH QUESTION HAS ONLY ONE ANSWER, BUT
EACH ANSWER MAY BE USED MORE THAN ONCE (OR NOT AT ALL).
A.
B.
C.
D.
E.
COXIELLA BURNETII
STREPTOCOCCUS PNEUMONIAE
MYCOPLASMA PNEUMONIAE
PSEUDOMONAS AERUGINOSA
LEGIONELLA PNEUMOPHILIA
D_____36. OFTEN CAUSES A FATAL PNEUMONIA IN CYSTIC FIBROSIS
PATIENTS
B_____37. THE CAUSE OF PRIMARY TYPICAL PNEUMONIA
E_____38. THE CAUSE OF AN ATYPICAL PNEUMONIA FIRST NOTED IN
DOWNTOWN PHILADELPHIA
A_____39. CAUSES AN ATYPICAL PNEUMONIA TRANSMITTED IN THE DUST OF
STOCKYARDS
C_____40. YOU CANNOT TREAT THIS AGENT OF PNEUMONIA WITH PENICILLINS
OR CEPHALASPORINS
MCB 2004
TEST #3-A
41. FILL IN THE FOLLOWING TABLE (10 POINTS):
BACTERIAL
AGENT
TOXIN CAUSES
SYMPTOMS
YES
_______
_______
SYPHILIS
_______
_______
_______
YELLOW FEVER
_______
_______
_______
ROCKY MTN SPOTTED
FEVER
_______
CHOLERA
_______
_______
_______
SERUM HEPATITIS
_______
_______
_______
GENITAL WARTS
_______
DISEASE
TYPHOID FEVER
DIPHTHERIA
YES
NO
NO
_______
PEDIATRIC VACCINE
AVAILABLE
_______
_______
_______
******************************************************************
ANSWER ONE OF THE FOLLOWING TWO QUESTIONS (10 POINTS)
42.
I HAVE DISCUSSED FOUR DIFFERENT COMBINATION DRUGS. DESCRIBE
TWO OF THESE DRUG COMBINATIONS (THE TWO COMPONENTS AND HOW
THEY WORK), AND TELL ME WHY THE TWO ARE USED TOGETHER.
43.
EXPLAIN THE DIFFERENCE BETWEEN ANTIGENIC DRIFT AND ANTIGENIC
SHIFT. WHICH VIRUS DEMONSTRATES THESE PROPERTIES, AND WHICH
VIRAL PROTEIN(S) IS/ARE AFFECTED. HOW ARE THE VIRUS AND THE
PROTEIN(S)CHANGED.