Majalah Kedokteran Andalas
Vol.22. No.1. Januari –Juni 1998
11
ARTIKEL PENELITIAN
DISTRIBUTION OF CELLS EXPRESSING FcRI,
FcRII AND FcRIII IN THE RHAUMATOID
SYNOVIUM
Eryati Darwin*
*Bagian Histologi, Fakultas Kedokteran Universitas Andalas, Padang
Abstract
Rheumatoid Arthritis (RA) is characterized bt chronic inflammation, infiltration
of cells, e.g. monocytes, lymphocytes and proliveration of connetive tissue. Fc
receptor for IgG (FcR) on macrophage, granulocytes and lymphocytes have been
shown to be important triggers of effector stimulating cells thorough these receptors.
We have investigated the distribution of cells bearing FcR of 12 RA Synovium
and three osteoarthrois (OA) from post operatif patients using monoclonal antibody
CD14, CD64, CDw32 and CD16 on serila cryostat section by immunohistology
staining methods.
Cells densities and degree of lymphocytes infiltration were significan high in RA
compared to OA. Frequencies of cells expressing FcRI, FcRII, and FcRIII were
calculated as percentage of the monocytes/macrophages. They range from 18 – 61
with no significan difference between RA and OA, and there was no correlation with
the degree of lymphocitic infiltration.
We observed distinctive patterns for three Fc receptor, suggesting that there
may be differential regulation and expression of these molecules on subpopulation
which might be of functionla importance.
Keywords : Rheumatoid Arthritis, Fc Receptors, monoclonal anti body
Majalah Kedokteran Andalas Vol.22. No. 1. Januari – Juni 1998