Role of Bioinformatics in the Genomic Era Limsoon Wong Kent Ridge Digital Labs Singapore Show & Tell What are the Themes of Bioinformatics? Bioinformatics = Data Mgmt + Knowledge Discovery Data Mgmt = Integration + Transformation + Cleansing Knowledge Discovery = Statistics + Algorithms + Databases Show & Tell What are the Benefits of Bioinformatics? To the patient: To the pharma: Save time, save cost, make more $ To the scientist: Show & Tell Better drug, better treatment Better science Transcription Start Prediction Show & Tell Transcription Start Prediction Results Show & Tell Medical Record Analysis age 49 64 58 58 58 chol 266 211 283 284 224 ecg Hyp Norm Hyp Hyp Abn heart 171 144 162 160 173 Looking for patterns that are Show & Tell sex M M F M M valid novel useful understandable sick N N N Y Y Medical Record Analysis Results DeEPs, the “emerging pattern’’ method Beats C4.5, CBA, LB, NB, TAN in 21 out of 32 UCI benchmarks Works for gene expressions ALL vs AML: DeEPS (1 gene) - 0/38 & 3/34 Slonim (50 genes) - 2/38 & 5/34 Colon: Show & Tell DeEPS (35 genes) - 4/62 Alon (1000 genes) - 6/62 Genome-Enabled Fruits A lot of genes & proteins that are candidate diagnosis indicators candidate prognosis indicators candidate drug targets What’s Next? Show & Tell Evaluate & Choose the Better Candidates Easier to access Uncomplicated to modulate Clear path to $ Has experience To do that, you will need to have …. Show & Tell A Molecular Connections Database consisting of... DISEASES INTERACTIONS PATENTS EXPRESSION MUTATIONS RELATED MOLECULES STRUCTURE Show & Tell Thank You Show & Tell